Title: A Cell‐Permeable Synthetic Transcription Factor Mimic
Abstract: Angewandte Chemie International EditionVolume 46, Issue 16 p. 2865-2868 Communication A Cell-Permeable Synthetic Transcription Factor Mimic† Xiangshu Xiao Dr., Xiangshu Xiao Dr. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this authorPeng Yu Dr., Peng Yu Dr. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this authorHyun-Suk Lim Dr., Hyun-Suk Lim Dr. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this authorDevanjan Sikder Dr., Devanjan Sikder Dr. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this authorThomas Kodadek Prof. Dr., Thomas Kodadek Prof. Dr. [email protected] Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this author Xiangshu Xiao Dr., Xiangshu Xiao Dr. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this authorPeng Yu Dr., Peng Yu Dr. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this authorHyun-Suk Lim Dr., Hyun-Suk Lim Dr. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this authorDevanjan Sikder Dr., Devanjan Sikder Dr. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this authorThomas Kodadek Prof. Dr., Thomas Kodadek Prof. Dr. [email protected] Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156Search for more papers by this author First published: 05 April 2007 https://doi.org/10.1002/anie.200604485Citations: 64 † We thank Dr. Bo Liu (UT Southwestern) for providing plasmids and reagents. We also thank Prof. Peter Dervan and Benjamin Edelson (California Institute of Technology) for their gracious assistance and advice regarding the synthesis of hairpin polyamides. This work was supported by grants from the National Institutes of Health (P01-DK58398) and the Welch Foundation (I-1299). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Do you copy? A cell-permeable synthetic transcription factor mimic composed of a DNA-binding hairpin polyamide and an activation-domain-like peptoid can turn on gene transcription in living cells. Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604485_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1C. D. Novina, P. A. Sharp, Nature 2004, 430, 161. 2C. Denison, T. Kodadek, Chem. Biol. 1998, 5, R 129. 3A. Z. Ansari, A. K. Mapp, Curr. Opin. Chem. Biol. 2002, 6, 765. 4H. D. Arndt, Angew. Chem. 2006, 118, 4654; Angew. Chem. Int. Ed. 2006, 45, 4552. 5R. R. Beerli, C. F. Barbas, Nat. Biotechnol. 2002, 20, 135. 6S. Y. Tan, D. Guschin, A. Davalos, Y. L. Lee, A. W. Snowden, Y. Jouvenot, H. S. Zhang, K. Howes, A. R. McNamara, A. Lai, C. Ullman, L. Reynolds, M. Moore, M. Isalan, L. P. Berg, B. Campos, H. Qi, S. K. Spratt, C. C. Case, C. O. Pabo, J. Campisi, P. D. Gregory, Proc. Natl. Acad. Sci. USA 2003, 100, 11997. 7Y. Kwonj, H. D. Arndt, M. Qian, Y. Choi, Y. Kawazoe, P. B. Dervan, M. Uesugi, J. Am. Chem. Soc. 2004, 126, 15940. 8M. Ptashne, Nature 1988, 335, 683. 9A. K. Mapp, A. Z. Ansari, M. Ptashne, P. B. Dervan, Proc. Natl. Acad. Sci. USA 2000, 97, 3930. 10M. Murty, H. Sugiyama, Biol. Pharm. Bull. 2004, 27, 468. 11R. J. Simon, R. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Y. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Proc. Natl. Acad. Sci. USA 1992, 89, 9367. 12I. Radhakrishnan, G. C. Perez-Alvarado, D. Parker, H. J. Dyson, M. R. Montminy, P. E. Wright, Cell 1997, 91, 741. 13P. B. Dervan, B. S. Edelson, Curr. Opin. Struct. Biol. 2003, 13, 284. 14B. Liu, P. Yu, P. G. Alluri, T. Kodadek, Mol. BioSyst. 2005, 1, 307. 15P. Yu, B. Liu, T. Kodadek, Nat. Biotechnol. 2005, 23, 746. 16B. Z. Olenyuk, G. J. Zhang, J. M. Klco, N. G. Nickols, W. G. Kaelin, P. B. Dervan, Proc. Natl. Acad. Sci. USA 2004, 101, 16768. 17B. Dudouet, R. Burnett, L. A. Dickinson, M. R. Wood, C. Melander, J. M. Belitsky, B. Edelson, N. Wurtz, C. Briehn, P. B. Dervan, J. M. Gottesfeld, Chem. Biol. 2003, 10, 859. 18L. Supekova, J. P. Pezacki, A. I. Su, C. J. Loweth, R. Riedl, B. Geierstanger, P. G. Schultz, D. E. Wemmer, Chem. Biol. 2002, 9, 821. 19See the Supporting Information (Figure S2) for the cell-permeability data of compound 1 conjugated to a dexamethasone derivative. 20B. Liu, P. G. Alluri, P. Yu, T. Kodadek, J. Am. Chem. Soc. 2005, 127, 8254. 21P. G. Alluri, B. Liu, P. Yu, X. Xiao, T. Kodadek, Mol. BioSyst. 2006, 2, 568. 22P. G. Alluri, M. M. Reddy, K. Bachhawat-Sikder, H. J. Olivos, T. Kodakek, J. Am. Chem. Soc. 2003, 125, 13995. Citing Literature Volume46, Issue16April 13, 2007Pages 2865-2868 ReferencesRelatedInformation
Publication Year: 2007
Publication Date: 2007-04-05
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 74
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot