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'have': [202, 262], 'read': [203], 'accept': [205], 'the': [206, 216, 245, 249, 269, 325, 424, 436, 491, 494, 521, 561, 578, 581, 674, 773, 846, 901, 1032, 1042, 1045, 1053, 1267, 1354, 1423, 1449, 1491, 1647], 'Wiley': [207], 'Online': [208], 'Library': [209], 'UseShareable': [214], 'LinkUse': [215], 'link': [217], 'a': [221, 236, 256, 321, 487, 696, 748, 897, 933, 969, 1038, 1263, 1318, 1480, 1486, 1702, 1764, 1791], 'article': [226], 'with': [227, 701], 'your': [228], 'friends': [229], 'colleagues.': [231], 'Learn': [232], 'more.Copy': [233], 'URL': [234], 'Share': [235], 'linkShare': [237], 'onEmailFacebookTwitterLinkedInRedditWechat': [238], 'Abstract': [239], 'Interleukin-1β': [240], '(ICE)': [243], 'processes': [244, 1426], 'inactive': [246, 425], 'proIL-1β': [247], 'proinflammatory': [250], 'mature': [251, 328, 1139], 'IL-1β.': [252], 'ICE': [253], 'belongs': [254], 'family': [257, 905], 'cysteine': [259, 752, 907, 1561, 1648], 'proteases': [260], 'that': [261, 1310, 1425, 1489], 'been': [263], 'implicated': [264], 'apoptosis.': [266, 633, 802, 1178], 'To': [267], 'address': [268], 'biological': [270], 'functions': [271], 'ICE,': [273], 'we': [274], 'generated': [275], 'ICE-deficient': [276, 282, 294, 305, 318, 343], 'through': [278], 'gene': [279, 523, 1050, 1272, 1452, 1788], 'targeting': [280], 'technology.': [281], 'developed': [284], 'normally,': [285], 'appeared': [286], 'healthy,': [287], 'were': [289, 345], 'fertile.': [290], 'Peritoneal': [291], 'macrophages': [292], 'from': [293, 303, 777, 1234, 1757, 1763], 'underwent': [296, 308], 'apoptosis': [297, 309, 680, 1005, 1030, 1079, 1256, 1445], 'normally': [298], 'upon': [299], 'ATP': [300, 771, 1307], 'treatment.': [301], 'Thymocytes': [302], 'young': [304], 'also': [307], 'when': [310, 1760], 'triggered': [311], 'dexamethasone,': [313], 'gamma': [314, 464], 'irradiation,': [315], 'or': [316], 'aging.': [317], 'had': [320, 331], 'major': [322], 'defect': [323], 'production': [326, 334, 1137], 'IL-1β': [329], 'impaired': [332, 1399, 1845], 'IL-1α': [333], 'on': [335, 1584], 'LPS': [336], 'stimulation': [337], 'vitro': [339], 'vivo.': [342, 781], 'resistant': [346, 469, 1143, 1361], 'LPS-induced': [348], 'endotoxic': [349, 471, 1145], 'shock.': [350, 472, 1146], 'J.': [351], 'Cell.': [352], 'Biochem.': [353], '64:27–32.': [354], '©': [355], '1997': [356], 'Wiley-Liss,': [357], 'Inc.': [358], 'References': [359], 'Alexander': [360], 'HR,': [361], 'Doherty': [362], 'GM,': [363], 'Buresh': [364], 'CM,': [365, 737], 'Venzon': [366], 'DJ,': [367, 662, 995, 1746], 'Norton': [368], 'JA': [369, 965], '(1991):': [370, 484, 794, 836], 'A': [371, 668, 809, 947, 983, 1073, 1558, 1579, 1653], 'recombinant': [372], 'human': [373, 670, 698, 750, 937, 1230, 1427, 1697], 'receptor': [374, 465, 1358], 'antagonist': [375], 'interleukin': [377, 496, 938, 1751], 'improves': [379], 'survival': [380], 'after': [381], 'lethal': [382], 'endotoxemia': [383], 'mice.': [385, 1851], 'J': [386, 427, 473, 500, 606, 615, 685, 715, 782, 861, 909, 1089, 1238, 1252, 1326, 1404, 1430, 1454, 1767], 'Exp': [387, 474, 1405], 'Med': [388, 475, 607, 616, 1406], '173:': [389], '1029–1032.': [390], 'Black': [391, 555, 1417, 1711], 'RA,': [392, 654, 831, 1221, 1552, 1726], 'Kronheim': [393, 547, 1413], 'SR,': [394, 548, 1414], 'Cantrell': [395], 'M,': [396, 459, 620, 868, 870, 880, 888, 1020, 1022, 1063, 1108, 1151, 1159, 1244, 1348, 1436, 1460, 1550, 1612, 1622, 1630, 1808], 'Deeley': [397], 'MC,': [398, 1606], 'March': [399, 545, 1415], 'CJ,': [400, 536, 546, 1416], 'Prickett': [401], 'KS,': [402], 'Wignall': [403], 'J,': [404, 727, 823, 866, 957, 1106, 1112, 1213, 1332, 1384, 1386, 1518, 1526, 1773], 'Conlon': [405], 'PJ,': [406], 'Cosman': [407], 'D,': [408, 457, 876, 1116, 1295, 1682, 1804, 1814], 'Hopp': [409], 'TP,': [410], 'Mochizuki': [411], 'DY': [412], '(1988):': [413, 1749], 'Generation': [414], 'biologically': [416], 'active': [417, 1229, 1696], 'interleukin-1': [418, 525, 597, 675, 712, 902, 1010, 1231, 1428, 1566, 1650, 1698, 1736, 1849], 'beta': [419, 526, 676, 848, 974, 1011, 1141, 1300, 1567, 1737, 1753], 'proteolytic': [421], 'cleavage': [422], 'precursor.': [426, 499], 'Biol': [428, 501, 716, 910, 1239, 1327, 1431, 1455, 1769], 'Chem': [429, 502, 717, 911, 1240, 1328, 1432, 1456], '263:': [430], '9437–9442.': [431], 'Capecchi': [432], 'MR': [433], '(1989):': [434, 966], 'Altering': [435], 'genome': [437], 'homologous': [439], 'recombination.': [440], 'Science': [441, 565, 1014], '244:': [442], '1288–1292.': [443], 'Car': [444], 'BD,': [445], 'Eng': [446], 'VM,': [447], 'Schnyder': [448], 'B,': [449, 538], 'Ozmen': [450], 'L,': [451, 729, 733, 1102, 1110, 1610, 1618, 1634], 'Huang': [452], 'S,': [453, 481, 1018, 1098, 1100, 1118, 1278, 1382, 1466, 1602, 1775, 1777], 'Gallay': [454], 'P,': [455, 884, 959, 1094, 1340, 1380, 1626], 'Heumann': [456], 'Aguet': [458], 'Ryffel': [460], 'B': [461], '(1994):': [462, 513, 694, 1027, 1580, 1643, 1693, 1731], 'Interferon': [463], 'are': [468, 1134, 1360], '179:': [476], '1437–1444.': [477], 'Carruth': [478], 'LM,': [479], 'Demczuk': [480], 'Mizel': [482], 'SB': [483], 'Involvement': [485, 626], 'calpain-like': [488], 'protease': [489, 630, 671, 753, 931, 1175, 1424, 1488, 1562, 1649], 'processing': [492, 844, 934, 1568], 'murine': [495, 522, 1085], 'alpha': [498], '266:': [503], '12162–12167.': [504], 'Casano': [505, 1523], 'FJ,': [506, 1524], 'Rolando': [507, 1200, 1539], 'AM,': [508, 1201, 1540], 'Mudgett': [509], 'JS,': [510], 'Molineaux': [511, 1218, 1513], 'SM': [512, 573, 592], 'The': [514, 594, 1783], 'structure': [515, 1645], 'complete': [517], 'nucleotide': [518], 'sequence': [519], 'encoding': [524], '(ICE).': [529], 'Genomics': [530], '20:': [531], '474–481.': [532], 'Cerretti': [533], 'DP,': [534], 'Kozlosky': [535], 'Mosley': [537], 'Nelson': [539], 'N,': [540, 817, 878], 'Ness': [541], 'KV,': [542], 'Greenstreet': [543], 'TA,': [544, 1390], 'Druck': [549], 'T,': [550, 664, 689, 721, 919, 1604, 1686], 'Cannizzaro': [551], 'LA,': [552, 1187, 1530, 1664], 'Huebner': [553], 'K,': [554, 917, 987, 1464, 1824], 'RA': [556, 999, 1418], '(1992):': [557, 1557], 'Molecular': [558], 'cloning': [559], 'enzyme.': [564, 714, 1013, 1057, 1739, 1797], '256:': [566], '97–100.': [567], 'Dinarello': [568, 589], 'CA,': [569, 590, 1624, 1812], 'Gelfand': [570], 'JA,': [571, 656, 833, 886, 989, 1554, 1616, 1680, 1714], 'Wolff': [572, 591], '(1993):': [574, 593, 1224, 1253, 1351, 1782], 'Anticytokine': [575], 'strategies': [576], 'treatment': [579], 'systemic': [582], 'inflammatory': [583], 'response': [584, 1305, 1847], 'syndrome.': [585], 'JAMA': [586], '269:': [587, 718, 1329], '1829–1835.': [588], 'role': [595], 'disease': [599], '[published': [600], 'erratum': [601], 'appears': [602], 'N': [604, 613], 'Engl': [605, 614], '1993': [608], 'Mar': [609], '11;': [610], '328(10):': [611], '744].': [612], '328:': [617], '106–113.': [618], 'Enari': [619], 'Hug': [621], 'H,': [622, 874, 921, 1096, 1157, 1246, 1336, 1802, 1826], 'Nagata': [623, 1277], 'S': [624, 808, 946, 982], '(1995):': [625, 667, 746, 770, 891, 1000, 1074, 1127, 1170, 1439, 1477, 1839], 'an': [628, 1173], 'ICE-like': [629], 'Fas-mediated': [632], 'Nature': [634, 1179, 1373, 1571, 1740], '375:': [635, 1180], '78–81.': [636], 'Faucheu': [637], 'C,': [638, 646, 658, 1104, 1816], 'Diu': [639], 'A,': [640, 723, 1344, 1628, 1636, 1820], 'Chan': [641], 'AWE,': [642], 'Blanchet': [643], 'A-M,': [644], 'Miossec': [645], 'Herve': [647], 'F,': [648, 1065, 1342], 'Collard-Dutilleul': [649], 'V,': [650], 'Gu': [651], 'Y,': [652, 915, 1338], 'Aldape': [653, 1725], 'Lippke': [655, 988], 'Rocher': [657], 'Su': [659, 996], 'MSS,': [660], 'Livingston': [661, 994, 1729], 'Hercend': [663], 'Lalanne': [665], 'J-L': [666], 'novel': [669, 697, 749, 898, 1559], 'similar': [672, 1040, 1793], 'induces': [679, 772], 'transfected': [682, 1765], 'cells.': [683, 1237], 'EMBO': [684], '14:': [686], '1914–1922.': [687], 'Fernandes-Alnemri': [688, 720], 'Litwack': [690, 742], 'G,': [691, 739, 743, 821, 955, 991, 1069, 1217, 1534, 1577], 'Alnemri': [692, 744], 'ES': [693, 745], 'CPP32,': [695], 'apoptotic': [699, 751], 'protein': [700, 708, 1039, 1792], 'homology': [702], 'Caenorhabditis': [704, 1046], 'elegans': [705, 1047, 1269, 1785], 'cell': [706, 1048, 1270, 1786], 'death': [707, 1049, 1271, 1492, 1787], 'Ced-3': [709], 'mammalian': [711, 1054, 1264, 1481, 1795], 'beta-converting': [713, 903, 1056, 1132, 1232, 1261, 1651], '30761–30764.': [719], 'Takahashi': [722], 'Armstrong': [724], 'R,': [725, 1124, 1248, 1346, 1640], 'Krebs': [726], 'Fritz': [728], 'Tomaselli': [730], 'KJ,': [731, 1810], 'Wang': [732, 1659], 'Yu': [734], 'Z,': [735, 1468], 'Croce': [736], 'Salveson': [738], 'Earnshaw': [740], 'WC,': [741], 'Mch3,': [747], 'highly': [754, 1366], 'related': [755], 'CPP32.': [757], 'Cancer': [758], 'Res': [759], '55:': [760], '6045–6052.': [761], 'Griffiths': [762], 'RJ,': [763, 1828], 'Stam': [764], 'EJ,': [765], 'Downs': [766], 'JT,': [767], 'Otterness': [768], 'IG': [769], 'release': [774, 1303], 'IL-1': [776, 847, 859, 1055, 1131, 1140, 1260], 'LPS-primed': [778], 'cells': [779], 'Immunol': [783, 862, 1290], '154:': [784], '2821–2828.': [785], 'Hogquist': [786, 826], 'KA,': [787, 827], 'Nett': [788], 'MA,': [789, 1688, 1720, 1722], 'Unanue': [790], 'ER,': [791], 'Chaplin': [792, 828, 1391], 'DD': [793, 1392], 'Interleukin': [795], 'is': [797, 1317, 1446, 1485, 1563, 1754], 'processed': [798], 'released': [800], 'during': [801], 'Proc': [803, 941, 977], 'Natl': [804, 942, 978], 'Acad': [805, 943, 979], 'Sci': [806, 944, 980], 'U': [807, 945, 981], '88:': [810], '8485–8489.': [811], 'Howard': [812, 1196, 1507], 'AD,': [813, 1197, 1508], 'Kostura': [814, 950, 1214, 1509, 1821], 'MJ,': [815, 951, 953, 1215, 1510, 1822, 1832, 1834], 'Thornberry': [816, 1204, 1499], 'Ding': [818, 1192, 1527], 'GJ,': [819, 1193], 'Limjuco': [820, 954, 1216, 1533], 'Weidner': [822, 1206, 1515], 'Salley': [824, 1202, 1541], 'JP,': [825, 1203, 1542, 1632, 1718], 'DD,': [829], 'Mumford': [830, 1220, 1551], 'Schmidt': [832, 964, 1553], 'Tocci': [834, 952, 1555, 1831], 'MJ': [835, 1556], 'IL-1-converting': [837], 'requires': [839], 'aspartic': [840], 'acid': [841], 'residues': [842], 'precursor': [849], 'at': [850], 'two': [851], 'distinct': [852], 'sites': [853], 'does': [855], 'not': [856, 1755], 'cleave': [857], '31-kDa': [858], 'alpha.': [860, 940], '147:': [863], '2964–2969.': [864], 'Kamens': [865], 'Paskind': [867, 1107, 1621], 'Hugunin': [869, 1611], 'Talanian': [871, 1591], 'RV,': [872, 1592, 1690], 'Banach': [875], 'Bump': [877, 1597], 'Hackett': [879, 1605], 'Johnston': [881, 1103], 'CG,': [882], 'Mankovich': [885, 1615], 'Terranova': [887, 1629], 'Ghayur': [889, 1603], 'T': [890, 1126, 1280], 'Identification': [892, 927, 967], 'characterization': [894, 1227], 'ICH-2,': [896], 'member': [899], 'proteases.': [908], '270:': [912, 1457], '15250–15256.': [913], 'Kobayashi': [914], 'Yamamoto': [916], 'Saido': [918], 'Kawasaki': [920], 'Oppen-heim': [922], 'JJ,': [923, 1674], 'Matsushima': [924], 'K': [925], '(1990):': [926, 1419], 'calcium-activated': [929], 'neutral': [930], 'as': [932], '87:': [948], '5548–5552.': [949], 'Chin': [956, 1525], 'Cameron': [958], 'Hillman': [960], 'AG,': [961], 'Chartrain': [962], 'NA,': [963, 1205, 1500], 'monocyte': [970], 'specific': [971], 'preinterleukin': [972], 'convertase': [975], 'activity.': [976, 1325], '86:': [984], '5227–5231.': [985], 'Kuida': [986], 'Ku': [990], 'Harding': [992], 'MW,': [993], 'MS,': [997], 'Flavell': [998], 'Altered': [1001], 'cytokine': [1002], 'export': [1003], '267:': [1015], '2000–2003.': [1016], 'Kumar': [1017], 'Kinoshita': [1019], 'Noda': [1021], 'Copeland': [1023], 'NG,': [1024], 'Jenkins': [1025], 'NA': [1026], 'Induction': [1028, 1254], 'mouse': [1033], 'Nedd2': [1034], 'gene,': [1035], 'which': [1036], 'encodes': [1037, 1790], 'product': [1043], 'ced-3': [1051, 1789], 'Gene': [1058, 1706], 'Dev': [1059], '8:': [1060], '1613–1626.': [1061], 'Leist': [1062], 'Gantner': [1064], 'Bohlinger': [1066], 'I,': [1067], 'Tiegs': [1068], 'Germann': [1070], 'PG,': [1071], 'Wendel': [1072], 'Tumor': [1075], 'necrosis': [1076, 1356, 1443], 'factor-induced': [1077, 1444], 'hepatocyte': [1078], 'precedes': [1080], 'liver': [1081], 'failure': [1082], 'experimental': [1084], 'shock': [1086], 'models.': [1087], 'Amer': [1088], 'Pathol': [1090], '146:': [1091], '1220–1234.': [1092], 'Franklin': [1099, 1601], 'Herzog': [1101, 1609], 'McDowell': [1105], 'Rodman': [1109], 'Salfeld': [1111], 'Towne': [1113], 'E,': [1114, 1620], 'Tracey': [1115, 1637], 'Wardwell': [1117], 'Wei': [1119], 'FY,': [1120], 'Wong': [1121, 1641], 'W,': [1122, 1163, 1167, 1334, 1614, 1806], 'Kamen': [1123, 1639], 'Mice': [1128, 1352, 1394], 'defective': [1135], 'Cell': [1147, 1274, 1496, 1586, 1656, 1768, 1798], '80:': [1148], '401–411.': [1149], 'Los': [1150], 'Van': [1152, 1835], 'dCM,': [1153], 'Penning': [1154], 'LC,': [1155, 1596], 'Schenk': [1156], 'Westendorp': [1158], 'Baeuerle': [1160], 'PA,': [1161], 'Droge': [1162], 'Krammer': [1164], 'PH,': [1165], 'Fiers': [1166], 'Schulze': [1168], 'OK': [1169], 'Requirement': [1171], 'ICE/CED-3': [1174], 'Fas/APO-1-mediated': [1177], '81–83.': [1181], 'Miller': [1182, 1511], 'DK,': [1183, 1512], 'Ayala': [1184, 1521], 'JM,': [1185, 1522], 'Egger': [1186, 1529], 'Raju': [1188, 1537], 'SM,': [1189, 1219, 1514, 1538], 'Yamin': [1190, 1543], 'TT,': [1191, 1544], 'Gaffney': [1194, 1531], 'EP,': [1195, 1532], 'Palyha': [1198], 'OC,': [1199, 1536], 'JR,': [1207, 1504, 1516], 'Williams': [1208], 'JH,': [1209], 'Chapman': [1210, 1505], 'KT,': [1211, 1506], 'Jackson': [1212], 'Calaycay': [1222, 1503], 'JR': [1223], 'Purification': [1225], 'THP.1': [1235], 'monocytic': [1236], '268:': [1241], '18062–18069.': [1242], 'Miura': [1243], 'Zhu': [1245], 'Rotello': [1247], 'Hartwieg': [1249], 'EA,': [1250], 'Yuan': [1251, 1772], 'fibroblasts': [1258, 1759], 'enzyme,': [1262], 'homolog': [1265, 1482], 'C.': [1268, 1784], 'ced-3.': [1273], '75:': [1275, 1799], '653–660.': [1276], 'Suda': [1279], '(1995)': [1281], 'Fas': [1282, 1284], 'ligand:': [1285], 'lpr': [1286], 'gld': [1288], 'mutations.': [1289], 'Today': [1291], '16:': [1292], '39–43.': [1293], 'Perregaux': [1294], 'Gabel': [1296], 'CA': [1297], '(1994)': [1298], 'Interleukin-1': [1299], 'maturation': [1301], 'nigericin-Evidence': [1309], 'potassium': [1311], 'depletion': [1312], 'mediated': [1313], 'these': [1315], 'agents': [1316], 'necessary': [1319], 'common': [1321], 'feature': [1322], 'their': [1324], '15195–15203.': [1330], 'Rothe': [1331], 'Lesslauer': [1333], 'Lotscher': [1335], 'Lang': [1337], 'Koebel': [1339], 'Kontgen': [1341], 'Althage': [1343], 'Zinkernagel': [1345], 'Steinmetz': [1347], 'Bluethmann': [1349], 'H': [1350], 'lacking': [1353], 'tumour': [1355], 'factor': [1357], 'TNF-mediated': [1363], 'toxicity': [1364], 'but': [1365], 'susceptible': [1367], 'infection': [1369], 'Listeria': [1371], 'monocytogenes.': [1372], '364:': [1374], '798–802.': [1375], 'Shornick': [1376], 'LP,': [1377], 'de': [1378], 'Togni': [1379], 'Mariathasan': [1381], 'Goellner': [1383], 'Strauss-Schoenberger': [1385], 'Karr': [1387], 'RW,': [1388], 'Ferguson': [1389], '(1996):': [1393], 'IL-1b': [1397], 'manifest': [1398], 'contact': [1400], 'hypersensitivity': [1401], 'trinitrochlorobenzene.': [1403], '183:': [1407], '1427–1436.': [1408], 'Sleath': [1409], 'PR,': [1410, 1744], 'Hendrickson': [1411], 'RC,': [1412, 1684], 'Substrate': [1420], 'specificity': [1421], 'beta.': [1429], '265:': [1433], '14526–14528.': [1434], 'Tewari': [1435, 1459], 'Dixit': [1437, 1475], 'VM': [1438, 1476], 'Fas-': [1440], 'tumor': [1442], 'inhibited': [1447], 'poxvirus': [1450], 'crmA': [1451], 'product.': [1453], '3255–3260.': [1458], 'Quan': [1461], 'LT,': [1462], "O'Rourke": [1463], 'Desnoyers': [1465], 'Zeng': [1467], 'Beidler': [1469], 'DR,': [1470], 'Poirier': [1471], 'GG,': [1472], 'Salvesen': [1473], 'GS,': [1474], 'Yama/CPP32': [1478], 'beta,': [1479], 'CED-3,': [1484], 'CrmA-inhibitable': [1487], 'cleaves': [1490], 'substrate': [1493], 'poly(ADP-ribose)': [1494], 'polymerase.': [1495], '81:': [1497], '801–809.': [1498], 'Bull': [1501], 'HG,': [1502], 'Aunins': [1517], 'Elliston': [1519], 'KO,': [1520], 'gJF,': [1528], 'Paylha': [1535], 'Lee': [1545], 'TD,': [1546], 'Shively': [1547], 'JE,': [1548], 'MacCross': [1549], 'heterodimeric': [1560], 'required': [1564], 'monocytes.': [1570], '356:': [1572], '768–774.': [1573], 'Vaux': [1574], 'DL,': [1575], 'Haecker': [1576], 'Strasser': [1578], 'An': [1581], 'Evolutionary': [1582], 'Perspective': [1583], 'Apoptosis.': [1585], '76:': [1587], '777–779.': [1588], 'Walker': [1589], 'NPC,': [1590], 'Brady': [1593], 'KD,': [1594], 'Dang': [1595], 'NJ,': [1598], 'Ferenz': [1599], 'CR,': [1600], 'Hammill': [1607], 'LD,': [1608], 'Houy': [1613], 'Mcguiness': [1617], 'Orlewicz': [1619], 'Pratt': [1623], 'Reis': [1625], 'Summani': [1627], 'Welch': [1631], 'Xiong': [1633], 'Moller': [1635], 'DE,': [1638], 'WW': [1642], 'Crystal': [1644], 'enzyme:': [1652], '(p20/p10)(2)': [1654], 'homodimer.': [1655], '78:': [1657], '343–352.': [1658], 'XM,': [1660], 'Helaszek': [1661], 'CT,': [1662], 'Winter': [1663], 'Lirette': [1665], 'RP,': [1666], 'Dixon': [1667], 'DC,': [1668], 'Ciccarelli': [1669], 'RB,': [1670], 'Kelley': [1671], 'MM,': [1672], 'Malinowski': [1673], 'Simmons': [1675], 'SJ,': [1676], 'Huston': [1677], 'EE,': [1678, 1716], 'Koehn': [1679], 'Kratz': [1681], 'Bruckner': [1683], 'Graybill': [1685], 'Ator': [1687], 'Lehr': [1689], 'Stevis': [1691], 'PE': [1692], 'Production': [1694], 'betaconverting': [1699], 'baculovirus': [1703], 'expression': [1704], 'system.': [1705], '145:': [1707], '273–277.': [1708], 'Wilson': [1709], 'KP,': [1710], 'JAF,': [1712], 'Thomson': [1713], 'Kim': [1715], 'Griffith': [1717], 'Navia': [1719], 'Murcko': [1721], 'Chambers': [1723], 'SP,': [1724], 'Raybuck': [1727], 'SA,': [1728], 'DJ': [1730], 'Structure': [1732], 'mechanism': [1734], '370:': [1741], '270–275.': [1742], 'Young': [1743], 'Hazuda': [1745], 'Simon': [1747], 'PL': [1748], 'Human': [1750], 'secreted': [1756], 'hamster': [1758], 'expressed': [1761], 'constitutively': [1762], 'cDNA.': [1766], '107:': [1770], '447–456.': [1771], 'Shaham': [1774], 'Ledoux': [1776], 'Ellis': [1778], 'HM,': [1779], 'Horvitz': [1780], 'HR': [1781], 'interleukin-1b-converting': [1796], '641–652.': [1800], 'Zheng': [1801], 'Fletcher': [1803], 'Kozak': [1805], 'Jiang': [1807], 'Hofmann': [1809], 'Conn': [1811], 'Soszynski': [1813], 'Grabiec': [1815], 'Trumbauer': [1817], 'ME,': [1818], 'Shaw': [1819], 'Stevens': [1823], 'Rosen': [1825], 'North': [1827], 'Chen': [1829], 'HY,': [1830], 'Kluger': [1833], 'der': [1836], 'Ploeg': [1837], 'LHT': [1838], 'Resistance': [1840], 'fever': [1842], 'induction': [1843], 'acutephase': [1846], 'beta-deficient': [1850], 'Immunity': [1852], '3:': [1853], '9–19.': [1854], 'Citing': [1855], 'Literature': [1856], 'Volume64,': [1857], 'Issue1January': [1858], '1997Pages': [1859], 'ReferencesRelatedInformation': [1861]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2108362910', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-15T09:28:54.436143', 'created_date': '2016-06-24'}