Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2107693762', 'doi': 'https://doi.org/10.1097/pas.0b013e31826485c0', 'title': 'Immunohistochemistry Is Highly Sensitive and Specific for the Detection of V600E BRAF Mutation in Melanoma', 'display_name': 'Immunohistochemistry Is Highly Sensitive and Specific for the Detection of V600E BRAF Mutation in Melanoma', 'publication_year': 2012, 'publication_date': '2012-10-01', 'ids': {'openalex': 'https://openalex.org/W2107693762', 'doi': 'https://doi.org/10.1097/pas.0b013e31826485c0', 'mag': '2107693762', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23026937'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/pas.0b013e31826485c0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S37879208', 'display_name': 'The American Journal of Surgical Pathology', 'issn_l': '0147-5185', 'issn': ['0147-5185', '1532-0979'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070576000', 'display_name': 'Georgina V. Long', 'orcid': 'https://orcid.org/0000-0001-8894-3545'}, 'institutions': [{'id': 'https://openalex.org/I2803024705', 'display_name': 'Westmead Hospital', 'ror': 'https://ror.org/04gp5yv64', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803024705']}, {'id': 'https://openalex.org/I4210137518', 'display_name': 'Westmead Institute', 'ror': 'https://ror.org/03wtqwa04', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210137518']}, {'id': 'https://openalex.org/I4210118383', 'display_name': 'Melanoma Institute Australia', 'ror': 'https://ror.org/02jxrhq31', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210118383']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Georgina V. Long', 'raw_affiliation_strings': ['Department of Medical Oncology, Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia', 'Georgina V. Long, MD, PhD, Melanoma Institute Australia and Westmead Hospital, 40 Rocklands Rd, North Sydney, NSW 2060, Australia (e-mail: [email\xa0protected]).', 'Medicine', 'Melanoma Institute Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia', 'institution_ids': ['https://openalex.org/I2803024705', 'https://openalex.org/I4210137518']}, {'raw_affiliation_string': 'Melanoma Institute Australia', 'institution_ids': ['https://openalex.org/I4210118383']}, {'raw_affiliation_string': 'Medicine', 'institution_ids': []}, {'raw_affiliation_string': 'Georgina V. Long, MD, PhD, Melanoma Institute Australia and Westmead Hospital, 40 Rocklands Rd, North Sydney, NSW 2060, Australia (e-mail: [email\xa0protected]).', 'institution_ids': ['https://openalex.org/I4210118383', 'https://openalex.org/I2803024705']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001606920', 'display_name': 'James S. Wilmott', 'orcid': 'https://orcid.org/0000-0002-6750-5244'}, 'institutions': [{'id': 'https://openalex.org/I4210118383', 'display_name': 'Melanoma Institute Australia', 'ror': 'https://ror.org/02jxrhq31', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210118383']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'James S. Wilmott', 'raw_affiliation_strings': ['Melanoma Institute Australia', 'Pathology'], 'affiliations': [{'raw_affiliation_string': 'Melanoma Institute Australia', 'institution_ids': ['https://openalex.org/I4210118383']}, {'raw_affiliation_string': 'Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039647180', 'display_name': 'David Capper', 'orcid': 'https://orcid.org/0000-0003-1945-497X'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'David Capper', 'raw_affiliation_strings': ['Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany', 'Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg'], 'affiliations': [{'raw_affiliation_string': 'Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057141936', 'display_name': 'Matthias Preusser', 'orcid': 'https://orcid.org/0000-0003-3541-2315'}, 'institutions': [{'id': 'https://openalex.org/I76134821', 'display_name': 'Medical University of Vienna', 'ror': 'https://ror.org/05n3x4p02', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I76134821']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I4210092129', 'display_name': 'Comprehensive Cancer Center Vienna', 'ror': 'https://ror.org/00df3z122', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802328216', 'https://openalex.org/I4210092129']}], 'countries': ['AT', 'DE'], 'is_corresponding': False, 'raw_author_name': 'Matthias Preusser', 'raw_affiliation_strings': ['Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria', 'Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria', 'institution_ids': ['https://openalex.org/I76134821', 'https://openalex.org/I4210092129']}, {'raw_affiliation_string': 'Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030544253', 'display_name': 'Yuxiao E. Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118383', 'display_name': 'Melanoma Institute Australia', 'ror': 'https://ror.org/02jxrhq31', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210118383']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Yuxiao E. Zhang', 'raw_affiliation_strings': ['Melanoma Institute Australia'], 'affiliations': [{'raw_affiliation_string': 'Melanoma Institute Australia', 'institution_ids': ['https://openalex.org/I4210118383']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035263718', 'display_name': 'John F. Thompson', 'orcid': 'https://orcid.org/0000-0002-2816-2496'}, 'institutions': [{'id': 'https://openalex.org/I4210118383', 'display_name': 'Melanoma Institute Australia', 'ror': 'https://ror.org/02jxrhq31', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210118383']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'John F. Thompson', 'raw_affiliation_strings': ['Medicine', 'Melanoma Institute Australia'], 'affiliations': [{'raw_affiliation_string': 'Medicine', 'institution_ids': []}, {'raw_affiliation_string': 'Melanoma Institute Australia', 'institution_ids': ['https://openalex.org/I4210118383']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062978331', 'display_name': 'Richard Kefford', 'orcid': 'https://orcid.org/0000-0001-9251-9229'}, 'institutions': [{'id': 'https://openalex.org/I4210118383', 'display_name': 'Melanoma Institute Australia', 'ror': 'https://ror.org/02jxrhq31', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210118383']}, {'id': 'https://openalex.org/I4210137518', 'display_name': 'Westmead Institute', 'ror': 'https://ror.org/03wtqwa04', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210137518']}, {'id': 'https://openalex.org/I2803024705', 'display_name': 'Westmead Hospital', 'ror': 'https://ror.org/04gp5yv64', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803024705']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Richard F. Kefford', 'raw_affiliation_strings': ['Department of Medical Oncology, Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia', 'Medicine', 'Melanoma Institute Australia'], 'affiliations': [{'raw_affiliation_string': 'Melanoma Institute Australia', 'institution_ids': ['https://openalex.org/I4210118383']}, {'raw_affiliation_string': 'Medicine', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Medical Oncology, Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia', 'institution_ids': ['https://openalex.org/I4210137518', 'https://openalex.org/I2803024705']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052657395', 'display_name': 'Andreas von Deimling', 'orcid': 'https://orcid.org/0000-0002-5863-540X'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas von Deimling', 'raw_affiliation_strings': ['Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany', 'Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg'], 'affiliations': [{'raw_affiliation_string': 'Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I17937529']}, {'raw_affiliation_string': 'Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083653505', 'display_name': 'Richard A. Scolyer', 'orcid': 'https://orcid.org/0000-0002-8991-0013'}, 'institutions': [{'id': 'https://openalex.org/I2803024705', 'display_name': 'Westmead Hospital', 'ror': 'https://ror.org/04gp5yv64', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803024705']}, {'id': 'https://openalex.org/I4210118383', 'display_name': 'Melanoma Institute Australia', 'ror': 'https://ror.org/02jxrhq31', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210118383']}, {'id': 'https://openalex.org/I4210137518', 'display_name': 'Westmead Institute', 'ror': 'https://ror.org/03wtqwa04', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210137518']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Richard A. Scolyer', 'raw_affiliation_strings': ['Department of Medical Oncology, Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia', 'Melanoma Institute Australia', 'Pathology'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia', 'institution_ids': ['https://openalex.org/I2803024705', 'https://openalex.org/I4210137518']}, {'raw_affiliation_string': 'Melanoma Institute Australia', 'institution_ids': ['https://openalex.org/I4210118383']}, {'raw_affiliation_string': 'Pathology', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5070576000', 'https://openalex.org/A5001606920', 'https://openalex.org/A5030544253', 'https://openalex.org/A5035263718', 'https://openalex.org/A5062978331', 'https://openalex.org/A5083653505'], 'corresponding_institution_ids': ['https://openalex.org/I2803024705', 'https://openalex.org/I4210137518', 'https://openalex.org/I4210118383', 'https://openalex.org/I4210118383', 'https://openalex.org/I4210118383', 'https://openalex.org/I4210118383', 'https://openalex.org/I4210118383', 'https://openalex.org/I4210137518', 'https://openalex.org/I2803024705', 'https://openalex.org/I2803024705', 'https://openalex.org/I4210118383', 'https://openalex.org/I4210137518'], 'apc_list': None, 'apc_paid': None, 'fwci': 23.224, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 287, 'citation_normalized_percentile': {'value': 0.999986, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '37', 'issue': '1', 'first_page': '61', 'last_page': '65'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10392', 'display_name': 'Melanoma', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 0.9819, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/v600e', 'display_name': 'V600E', 'score': 0.6380652}, {'id': 'https://openalex.org/keywords/melanoma', 'display_name': 'Melanoma', 'score': 0.552204}, {'id': 'https://openalex.org/keywords/braf-gene', 'display_name': 'BRAF gene', 'score': 0.526777}, {'id': 'https://openalex.org/keywords/mutation-testing', 'display_name': 'Mutation testing', 'score': 0.4321755}], 'concepts': [{'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.7748455}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.7537893}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.655465}, {'id': 'https://openalex.org/C2776470698', 'wikidata': 'https://www.wikidata.org/wiki/Q21851559', 'display_name': 'V600E', 'level': 4, 'score': 0.6380652}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.625795}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.61207354}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48530954}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.44490296}, {'id': 'https://openalex.org/C163565370', 'wikidata': 'https://www.wikidata.org/wiki/Q4308623', 'display_name': 'Mutation testing', 'level': 4, 'score': 0.4321755}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42961097}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.34125036}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29690963}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23381996}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1887024}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11062175}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.058074474}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011237', 'descriptor_name': 'Predictive Value of Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048493', 'descriptor_name': 'Proto-Oncogene Proteins B-raf', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015203', 'descriptor_name': 'Reproducibility of Results', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012680', 'descriptor_name': 'Sensitivity and Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/pas.0b013e31826485c0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S37879208', 'display_name': 'The American Journal of Surgical Pathology', 'issn_l': '0147-5185', 'issn': ['0147-5185', '1532-0979'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23026937', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.82, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1969870912', 'https://openalex.org/W1975587495', 'https://openalex.org/W1985389686', 'https://openalex.org/W2006412460', 'https://openalex.org/W2030330538', 'https://openalex.org/W2039861849', 'https://openalex.org/W2040584053', 'https://openalex.org/W2048738726', 'https://openalex.org/W2056199226', 'https://openalex.org/W2056362223', 'https://openalex.org/W2060060906', 'https://openalex.org/W2093801202', 'https://openalex.org/W2106494998', 'https://openalex.org/W2110092889', 'https://openalex.org/W2114545185', 'https://openalex.org/W2118863192', 'https://openalex.org/W2121377606', 'https://openalex.org/W2128542677', 'https://openalex.org/W2135925159', 'https://openalex.org/W2144026118', 'https://openalex.org/W2146267855', 'https://openalex.org/W2163188200', 'https://openalex.org/W2166262263', 'https://openalex.org/W2171940397'], 'related_works': ['https://openalex.org/W2951506308', 'https://openalex.org/W2777626578', 'https://openalex.org/W2546792321', 'https://openalex.org/W2232482475', 'https://openalex.org/W2171407797', 'https://openalex.org/W2165310406', 'https://openalex.org/W2139763472', 'https://openalex.org/W2123958666', 'https://openalex.org/W2050957808', 'https://openalex.org/W1517493216'], 'abstract_inverted_index': {'This': [0], 'study': [1], 'investigated': [2], 'the': [3, 17, 20, 64, 81, 104, 112, 117, 125, 141, 151, 170, 173, 205], 'sensitivity': [4, 92], 'and': [5, 47, 78, 96, 191, 218], 'specificity': [6, 98], 'of': [7, 19, 31, 93, 99, 106, 116, 159, 172, 204], 'immunohistochemical': [8], '(IHC)': [9], 'analysis': [10, 139], 'using': [11, 72], 'an': [12, 188], 'anti-BRAF': [13], 'antibody': [14, 89, 126, 208], 'to': [15, 214, 225], 'detect': [16], 'presence': [18, 105], 'BRAF': [21, 52, 65, 83, 108, 134, 144, 167, 197, 207], 'V600E': [22, 84, 109, 196, 206, 220], 'mutation': [23, 53, 66, 135, 176, 216], 'in': [24, 146, 199], 'patients': [25, 33, 161, 224], 'with': [26, 34, 80, 124, 132], 'metastatic': [27, 222], 'melanoma.': [28], 'A': [29], 'total': [30], '100': [32], 'American': [35], 'Joint': [36], 'Committee': [37], 'on': [38, 169], 'Cancer': [39], 'stage': [40, 44], 'IIIC': [41], 'unresectable': [42], 'or': [43], 'IV': [45], 'melanoma': [46, 59, 200, 223], 'who': [48], 'underwent': [49], 'tumor': [50], 'DNA': [51, 75], 'testing': [54, 154, 177, 217], 'were': [55, 61, 129, 156], 'selected.': [56], 'Paraffin-embedded,': [57], 'formalin-fixed': [58], 'biopsies': [60], 'analyzed': [62], 'for': [63, 102, 194], 'status': [67], 'by': [68], 'independent,': [69], 'blinded': [70], 'observers': [71], 'both': [73], 'conventional': [74, 215], 'molecular': [76, 138, 153], 'techniques': [77], 'IHC': [79, 185], 'novel': [82], 'mutant-specific': [85], 'antibody,': [86], 'VE1.': [87], 'The': [88, 183], 'had': [90], 'a': [91, 97, 107, 166, 211], '97%': [94], '(37/38)': [95], '98%': [100], '(58/59)': [101], 'detecting': [103, 195], 'mutation.': [110], 'Of': [111], 'BRAF-mutated': [113], 'cases,': [114, 148], 'none': [115], 'non-V600E': [118], 'cases': [119, 131, 180], '(including': [120], 'V600K)': [121], 'stained': [122], 'positive': [123], '(0/11).': [127], 'There': [128], '5': [130], 'discordant': [133], 'results.': [136], 'Additional': [137], 'confirmed': [140], 'immunohistochemically': [142], 'obtained': [143], 'result': [145], '3': [147], 'suggesting': [149], 'that': [150], 'initial': [152, 174], 'results': [155], 'incorrect.': [157], 'Two': [158, 179], 'these': [160], 'would': [162], 'not': [163], 'have': [164], 'received': [165], 'inhibitor': [168], 'basis': [171], 'false-negative': [175], 'result.': [178], 'remained': [181], 'discordant.': [182], 'reported': [184], 'method': [186, 193], 'is': [187], 'accurate,': [189], 'rapid,': [190], 'cost-effective': [192], 'mutations': [198], 'patients.': [201], 'Clinical': [202], 'use': [203], 'should': [209], 'be': [210, 226], 'valuable': [212], 'supplement': [213], 'allow': [219], 'mutant': [221], 'triaged': [227], 'rapidly': [228], 'into': [229], 'appropriate': [230], 'treatment': [231], 'pathways.': [232]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2107693762', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 43}, {'year': 2015, 'cited_by_count': 47}, {'year': 2014, 'cited_by_count': 51}, {'year': 2013, 'cited_by_count': 33}], 'updated_date': '2024-09-24T19:03:37.574195', 'created_date': '2016-06-24'}