Title: The pancreatic ductal epithelium serves as a potential pool of progenitor cells
Abstract: Pediatric DiabetesVolume 5, Issue s2 p. 16-22 The pancreatic ductal epithelium serves as a potential pool of progenitor cells Susan Bonner-Weir, Corresponding Author Susan Bonner-Weir Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Dr Susan Bonner-Weir Joslin Diabetes Center 1 Joslin Place, Boston MA 02215, USA Tel: +1-617-732-2581 fax: +1-617-732-2650 e-mail: [email protected]Search for more papers by this authorElena Toschi, Elena Toschi Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorAkari Inada, Akari Inada Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorPetra Reitz, Petra Reitz Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorSonya Y. Fonseca, Sonya Y. Fonseca Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorTandy Aye, Tandy Aye Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorArun Sharma, Arun Sharma Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this author Susan Bonner-Weir, Corresponding Author Susan Bonner-Weir Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Dr Susan Bonner-Weir Joslin Diabetes Center 1 Joslin Place, Boston MA 02215, USA Tel: +1-617-732-2581 fax: +1-617-732-2650 e-mail: [email protected]Search for more papers by this authorElena Toschi, Elena Toschi Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorAkari Inada, Akari Inada Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorPetra Reitz, Petra Reitz Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorSonya Y. Fonseca, Sonya Y. Fonseca Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorTandy Aye, Tandy Aye Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this authorArun Sharma, Arun Sharma Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USASearch for more papers by this author First published: 13 December 2004 https://doi.org/10.1111/j.1399-543X.2004.00075.xCitations: 228Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Abstract: With the increasing success of islet transplantation, β-cell replacement therapy has had renewed interest. To make such a therapy available to more than a few of the thousands of patients with diabetes, new sources of insulin-producing cells must become readily available. The most promising sources are stem cells, whether embryonic or adult stem cells. Clearly identifiable adult pancreatic stem cells have yet to be characterized. Although considerable evidence suggests their possibility, recent lineage-tracing experiments challenge their existence. Even in light of these lineage-tracing experiments, we suggest that evidence for neogenesis or new islet formation after birth remains strong. Our work has suggested that the pancreatic duct epithelium itself serves as a pool for progenitors for both islet and acinar tissues after birth and into adulthood and, thus, that the duct epithelium can be considered ‘facultative stem cells’. 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