Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2107160851', 'doi': 'https://doi.org/10.1093/jb/mvh053', 'title': 'Nerve Growth Factor Attenuates Endoplasmic Reticulum Stress-Mediated Apoptosis via Suppression of Caspase-12 Activity', 'display_name': 'Nerve Growth Factor Attenuates Endoplasmic Reticulum Stress-Mediated Apoptosis via Suppression of Caspase-12 Activity', 'publication_year': 2004, 'publication_date': '2004-03-01', 'ids': {'openalex': 'https://openalex.org/W2107160851', 'doi': 'https://doi.org/10.1093/jb/mvh053', 'mag': '2107160851', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15113843'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/jb/mvh053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S184547178', 'display_name': 'The Journal of Biochemistry', 'issn_l': '0021-924X', 'issn': ['0021-924X', '1756-2651'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052645697', 'display_name': 'Koji Shimoke', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I56624758', 'display_name': 'Kansai University', 'ror': 'https://ror.org/03xg1f311', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I56624758']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'K. Shimoke', 'raw_affiliation_strings': ['Laboratory of Neurobiology, Faculty of Engineering and High Technology Research Center (HRC), Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Neurobiology, Faculty of Engineering and High Technology Research Center (HRC), Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680. [email protected]', 'institution_ids': ['https://openalex.org/I56624758']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5052645697'], 'corresponding_institution_ids': ['https://openalex.org/I56624758'], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.613, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.771008, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '135', 'issue': '3', 'first_page': '439', 'last_page': '446'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 0.9806, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9547, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tunicamycin', 'display_name': 'Tunicamycin', 'score': 0.8545002}, {'id': 'https://openalex.org/keywords/caspase-12', 'display_name': 'Caspase 12', 'score': 0.5384386}, {'id': 'https://openalex.org/keywords/er-stress', 'display_name': 'ER Stress', 'score': 0.533057}, {'id': 'https://openalex.org/keywords/endoplasmic-reticulum', 'display_name': 'Endoplasmic Reticulum', 'score': 0.532122}, {'id': 'https://openalex.org/keywords/caspase-9', 'display_name': 'Caspase-9', 'score': 0.47872803}], 'concepts': [{'id': 'https://openalex.org/C2777575526', 'wikidata': 'https://www.wikidata.org/wiki/Q3542091', 'display_name': 'Tunicamycin', 'level': 4, 'score': 0.8545002}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.84533226}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.77367157}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.75351465}, {'id': 'https://openalex.org/C2778423431', 'wikidata': 'https://www.wikidata.org/wiki/Q417782', 'display_name': 'Nerve growth factor', 'level': 3, 'score': 0.6754592}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6115401}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.55928016}, {'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.5420343}, {'id': 'https://openalex.org/C2780292996', 'wikidata': 'https://www.wikidata.org/wiki/Q18068044', 'display_name': 'Caspase 12', 'level': 5, 'score': 0.5384386}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.51009184}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.5024259}, {'id': 'https://openalex.org/C2775998712', 'wikidata': 'https://www.wikidata.org/wiki/Q14907714', 'display_name': 'Caspase-9', 'level': 5, 'score': 0.47872803}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4582024}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.3112502}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31094056}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.2129429}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17166284}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D061945', 'descriptor_name': 'Caspase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D020932', 'descriptor_name': 'Nerve Growth Factor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053454', 'descriptor_name': 'Caspase 12', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020169', 'descriptor_name': 'Caspases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020169', 'descriptor_name': 'Caspases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002867', 'descriptor_name': 'Chromones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002867', 'descriptor_name': 'Chromones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048670', 'descriptor_name': 'MAP Kinase Kinase 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048728', 'descriptor_name': 'MAP Kinase Kinase Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048728', 'descriptor_name': 'MAP Kinase Kinase Kinase 1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D048728', 'descriptor_name': 'MAP Kinase Kinase Kinase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020929', 'descriptor_name': 'Mitogen-Activated Protein Kinase Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020929', 'descriptor_name': 'Mitogen-Activated Protein Kinase Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D020929', 'descriptor_name': 'Mitogen-Activated Protein Kinase Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009025', 'descriptor_name': 'Morpholines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009025', 'descriptor_name': 'Morpholines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020932', 'descriptor_name': 'Nerve Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016716', 'descriptor_name': 'PC12 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014415', 'descriptor_name': 'Tunicamycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014415', 'descriptor_name': 'Tunicamycin', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014415', 'descriptor_name': 'Tunicamycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/jb/mvh053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S184547178', 'display_name': 'The Journal of Biochemistry', 'issn_l': '0021-924X', 'issn': ['0021-924X', '1756-2651'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15113843', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4247821192', 'https://openalex.org/W3173711992', 'https://openalex.org/W2154710278', 'https://openalex.org/W2128747093', 'https://openalex.org/W2094593262', 'https://openalex.org/W2093340216', 'https://openalex.org/W2080007135', 'https://openalex.org/W2031715152', 'https://openalex.org/W2025682198', 'https://openalex.org/W1972635603'], 'abstract_inverted_index': {'Journal': [0, 120], 'Article': [1], 'Nerve': [2], 'Growth': [3], 'Factor': [4], 'Attenuates': [5], 'Endoplasmic': [6], 'Reticulum': [7], 'Stress-Mediated': [8], 'Apoptosis': [9], 'via': [10], 'Suppression': [11], 'of': [12, 121], 'Caspase-12': [13], 'Activity': [14], 'Get': [15], 'access': [16], 'Koji': [17, 19], 'Shimoke,': [18], 'Shimoke': [20], 'Search': [21, 38, 55, 72, 89, 106], 'for': [22, 39, 56, 73, 90, 107], 'other': [23, 40, 57, 74, 91, 108], 'works': [24, 41, 58, 75, 92, 109], 'by': [25, 42, 59, 76, 93, 110], 'this': [26, 43, 60, 77, 94, 111], 'author': [27, 44, 61, 78, 95, 112], 'on:': [28, 45, 62, 79, 96, 113], 'Oxford': [29, 46, 63, 80, 97, 114], 'Academic': [30, 47, 64, 81, 98, 115], 'PubMed': [31, 48, 65, 82, 99, 116], 'Google': [32, 49, 66, 83, 100, 117], 'Scholar': [33, 50, 67, 84, 101, 118], 'Hisayuki': [34, 36], 'Amano,': [35], 'Amano': [37], 'Soichiro': [51, 53], 'Kishi,': [52], 'Kishi': [54], 'Hitoshi': [68, 70], 'Uchida,': [69], 'Uchida': [71], 'Motoshige': [85, 87], 'Kudo,': [86], 'Kudo': [88], 'Toshihiko': [102, 104], 'Ikeuchi': [103, 105], 'The': [119], 'Biochemistry,': [122], 'Volume': [123], '135,': [124], 'Issue': [125], '3,': [126], 'March': [127, 134], '2004,': [128], 'Pages': [129], '439–446,': [130], 'https://doi.org/10.1093/jb/mvh053': [131], 'Published:': [132], '01': [133], '2004': [135]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2107160851', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-09-01T03:49:24.771378', 'created_date': '2016-06-24'}