Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2107148353', 'doi': 'https://doi.org/10.1111/j.1365-2958.1992.tb01548.x', 'title': 'The influence of ribosome‐binding‐site elements on translational efficiency in <i>Bacillus subtilis</i> and <i>Escherichia coli in vivo</i>', 'display_name': 'The influence of ribosome‐binding‐site elements on translational efficiency in <i>Bacillus subtilis</i> and <i>Escherichia coli in vivo</i>', 'publication_year': 1992, 'publication_date': '1992-05-01', 'ids': {'openalex': 'https://openalex.org/W2107148353', 'doi': 'https://doi.org/10.1111/j.1365-2958.1992.tb01548.x', 'mag': '2107148353', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1375309'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2958.1992.tb01548.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102549058', 'display_name': 'Molecular Microbiology', 'issn_l': '0950-382X', 'issn': ['0950-382X', '1365-2958'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035662589', 'display_name': 'Robert Luis Vellanoweth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I72951846', 'display_name': 'Washington State University', 'ror': 'https://ror.org/05dk0ce17', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I72951846']}, {'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Luis Vellanoweth', 'raw_affiliation_strings': ['Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Barker Hall, Berkeley, California 94720, USA.', 'Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA.', 'institution_ids': ['https://openalex.org/I72951846']}, {'raw_affiliation_string': 'Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Barker Hall, Berkeley, California 94720, USA.', 'institution_ids': ['https://openalex.org/I95457486']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5086436462', 'display_name': 'Jesse C. Rabinowitz', 'orcid': 'https://orcid.org/0000-0001-6144-2476'}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jesse C. Rabinowitz', 'raw_affiliation_strings': ['Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Barker Hall, Berkeley, California 94720, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Barker Hall, Berkeley, California 94720, USA.', 'institution_ids': ['https://openalex.org/I95457486']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5086436462'], 'corresponding_institution_ids': ['https://openalex.org/I95457486'], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.139, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 300, 'citation_normalized_percentile': {'value': 0.999963, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '9', 'first_page': '1105', 'last_page': '1114'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Genetics and Biotechnology', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ribosomal-binding-site', 'display_name': 'Ribosomal binding site', 'score': 0.82145}, {'id': 'https://openalex.org/keywords/translational-efficiency', 'display_name': 'Translational efficiency', 'score': 0.63318855}, {'id': 'https://openalex.org/keywords/eukaryotic-translation', 'display_name': 'Eukaryotic translation', 'score': 0.50563884}, {'id': 'https://openalex.org/keywords/shine-dalgarno-sequence', 'display_name': 'Shine-Dalgarno sequence', 'score': 0.4849887}, {'id': 'https://openalex.org/keywords/translational-regulation', 'display_name': 'Translational regulation', 'score': 0.47138152}], 'concepts': [{'id': 'https://openalex.org/C2777272437', 'wikidata': 'https://www.wikidata.org/wiki/Q131238', 'display_name': 'Bacillus subtilis', 'level': 3, 'score': 0.89112884}, {'id': 'https://openalex.org/C114847915', 'wikidata': 'https://www.wikidata.org/wiki/Q16948788', 'display_name': 'Ribosomal binding site', 'level': 5, 'score': 0.82145}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7845611}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.7576216}, {'id': 'https://openalex.org/C88478588', 'wikidata': 'https://www.wikidata.org/wiki/Q42244', 'display_name': 'Ribosome', 'level': 4, 'score': 0.7358558}, {'id': 'https://openalex.org/C176990463', 'wikidata': 'https://www.wikidata.org/wiki/Q1854186', 'display_name': 'Start codon', 'level': 4, 'score': 0.6453755}, {'id': 'https://openalex.org/C2775992057', 'wikidata': 'https://www.wikidata.org/wiki/Q16956568', 'display_name': 'Translational efficiency', 'level': 5, 'score': 0.63318855}, {'id': 'https://openalex.org/C149364088', 'wikidata': 'https://www.wikidata.org/wiki/Q185917', 'display_name': 'Translation (biology)', 'level': 4, 'score': 0.5470806}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.5431437}, {'id': 'https://openalex.org/C4718897', 'wikidata': 'https://www.wikidata.org/wiki/Q5408698', 'display_name': 'Eukaryotic translation', 'level': 5, 'score': 0.50563884}, {'id': 'https://openalex.org/C55334214', 'wikidata': 'https://www.wikidata.org/wiki/Q416807', 'display_name': 'Shine-Dalgarno sequence', 'level': 5, 'score': 0.4849887}, {'id': 'https://openalex.org/C39685955', 'wikidata': 'https://www.wikidata.org/wiki/Q3455905', 'display_name': 'Translational regulation', 'level': 5, 'score': 0.47138152}, {'id': 'https://openalex.org/C3675279', 'wikidata': 'https://www.wikidata.org/wiki/Q211935', 'display_name': 'Protein biosynthesis', 'level': 2, 'score': 0.4362852}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.37363252}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32024497}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.24590766}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.17265832}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.16231716}], 'mesh': [{'descriptor_ui': 'D001412', 'descriptor_name': 'Bacillus subtilis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012329', 'descriptor_name': 'RNA, Bacterial', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012270', 'descriptor_name': 'Ribosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001412', 'descriptor_name': 'Bacillus subtilis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003062', 'descriptor_name': 'Codon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012329', 'descriptor_name': 'RNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012270', 'descriptor_name': 'Ribosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012270', 'descriptor_name': 'Ribosomes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014169', 'descriptor_name': 'Transformation, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001616', 'descriptor_name': 'beta-Galactosidase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001616', 'descriptor_name': 'beta-Galactosidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2958.1992.tb01548.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102549058', 'display_name': 'Molecular Microbiology', 'issn_l': '0950-382X', 'issn': ['0950-382X', '1365-2958'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1375309', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land', 'score': 0.52}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 61, 'referenced_works': ['https://openalex.org/W123626623', 'https://openalex.org/W141039805', 'https://openalex.org/W1505823785', 'https://openalex.org/W1513717105', 'https://openalex.org/W1546783991', 'https://openalex.org/W154908185', 'https://openalex.org/W1553034254', 'https://openalex.org/W1572796244', 'https://openalex.org/W1606217776', 'https://openalex.org/W1606269023', 'https://openalex.org/W1812009168', 'https://openalex.org/W191517201', 'https://openalex.org/W1969129456', 'https://openalex.org/W1971308369', 'https://openalex.org/W1975907920', 'https://openalex.org/W1976137650', 'https://openalex.org/W1976490977', 'https://openalex.org/W1981371363', 'https://openalex.org/W1982501179', 'https://openalex.org/W1986902849', 'https://openalex.org/W1990115953', 'https://openalex.org/W1991004031', 'https://openalex.org/W1991597959', 'https://openalex.org/W2000219748', 'https://openalex.org/W2001452629', 'https://openalex.org/W2011101606', 'https://openalex.org/W2012344563', 'https://openalex.org/W2013002258', 'https://openalex.org/W2018853395', 'https://openalex.org/W2019221147', 'https://openalex.org/W2019410656', 'https://openalex.org/W2026554657', 'https://openalex.org/W2027055740', 'https://openalex.org/W2031103889', 'https://openalex.org/W2032009967', 'https://openalex.org/W2032754350', 'https://openalex.org/W2034252613', 'https://openalex.org/W2038386417', 'https://openalex.org/W2038398400', 'https://openalex.org/W2041033634', 'https://openalex.org/W2043624772', 'https://openalex.org/W2054543401', 'https://openalex.org/W2057411535', 'https://openalex.org/W2062246054', 'https://openalex.org/W2074703985', 'https://openalex.org/W2087091691', 'https://openalex.org/W2087588365', 'https://openalex.org/W2094333855', 'https://openalex.org/W2099474689', 'https://openalex.org/W2113338791', 'https://openalex.org/W2132963003', 'https://openalex.org/W2138840910', 'https://openalex.org/W2154632747', 'https://openalex.org/W2166064969', 'https://openalex.org/W2197678796', 'https://openalex.org/W2403604522', 'https://openalex.org/W2482835637', 'https://openalex.org/W2484736356', 'https://openalex.org/W3022487561', 'https://openalex.org/W337754501', 'https://openalex.org/W4231998357'], 'related_works': ['https://openalex.org/W3012924811', 'https://openalex.org/W2952971312', 'https://openalex.org/W2126336673', 'https://openalex.org/W2094333855', 'https://openalex.org/W2090177395', 'https://openalex.org/W2009105413', 'https://openalex.org/W1986050671', 'https://openalex.org/W1985367916', 'https://openalex.org/W1983106607', 'https://openalex.org/W1494294193'], 'abstract_inverted_index': {'Summary': [0], 'A': [1], 'method': [2], 'is': [3], 'described': [4, 208], 'to': [5, 35, 106, 159, 192, 197], 'determine': [6], 'simultaneously': [7], 'the': [8, 14, 38, 43, 47, 50, 63, 100, 143, 146, 164, 175, 179], 'effect': [9, 180], 'of': [10, 18, 40, 76, 128, 145, 181, 215], 'any': [11], 'changes': [12], 'in': [13, 23, 29, 62, 118, 149, 163, 178, 190, 200], 'ribosome‐binding': [15], 'site': [16], '(RBS)': [17], 'mRNA': [19, 188], 'on': [20, 59, 131, 142, 185], 'translational': [21, 60, 138, 203], 'efficiency': [22], 'Bacillus': [24], 'subtilis': [25, 68, 81, 120, 153], 'and': [26, 46, 55, 69, 212], 'Escherichia': [27], 'coli': [28, 71, 110], 'vivo.': [30], 'The': [31, 126, 206], 'approach': [32, 207], 'was': [33, 99, 112, 122, 140], 'used': [34], 'analyse': [36], 'systematically': [37], 'influence': [39], 'spacing': [41, 74], 'between': [42, 174], 'Shine‐Dalgarno': [44, 147], 'sequence': [45], 'initiation': [48, 53, 102, 132], 'codon,': [49], 'three': [51], 'different': [52], 'codons,': [54], 'RBS': [56, 165, 183], 'secondary': [57, 161], 'structure': [58, 162], 'yields': [61], 'two': [64, 176], 'organisms.': [65, 151], 'Both': [66], 'B.': [67, 80, 119, 152], 'E.': [70, 93, 167], 'exhibited': [72], 'similar': [73], 'optima': [75], '7–9': [77], 'nucleotides.': [78], 'However,': [79], 'translated': [82], 'messages': [83], 'with': [84], 'spacings': [85], 'shorter': [86], 'than': [87, 92, 115, 124, 166], 'optimal': [88], 'much': [89, 156], 'less': [90, 157], 'efficiently': [91], 'coli.': [94, 168], 'In': [95, 108], 'both': [96, 150], 'organisms,': [97], 'AUG': [98], 'preferred': [101], 'codon': [103, 133], 'by': [104, 137], 'two‐': [105], 'threefold.': [107], 'E': [109], 'GUG': [111], 'slightly': [113], 'better': [114, 123], '(JUG': [116], 'while': [117], 'UUG': [121], 'GUG.': [125], 'degree': [127], 'emphasis': [129], 'placed': [130], 'type,': [134], 'as': [135], 'measured': [136], 'yield,': [139], 'dependent': [141], 'strength': [144], 'interaction': [148], 'v/as': [154], 'also': [155], 'able': [158], 'tolerate': [160], 'While': [169], 'significant': [170], 'differences': [171], 'were': [172], 'found': [173], 'organisms': [177], 'specific': [182], 'elements': [184, 194], 'translation,': [186], 'other': [187], 'components': [189], 'addition': [191], 'those': [193], 'tested': [195], 'appear': [196], 'be': [198], 'responsible,': [199], 'part,': [201], 'for': [202], 'species': [204], 'specificity.': [205], 'provides': [209], 'a': [210], 'rapid': [211], 'systematic': [213], 'means': [214], 'elucidating': [216], 'such': [217], 'additional': [218], 'determinants.': [219]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2107148353', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-17T10:25:27.446140', 'created_date': '2016-06-24'}