Title: Epileptogenesis: Contributions of calcium ions and antiepileptic calcium antagonists
Abstract: Acta Neurologica ScandinavicaVolume 86, Issue S140 p. 41-46 Epileptogenesis: Contributions of calcium ions and antiepileptic calcium antagonists J. Walden, J. Walden Psychiatrische Universitätsklinik, FreiburgSearch for more papers by this authorH. Straub, H. Straub Institut für Physiologie, Universität, MünsterSearch for more papers by this authorE. J. Speckmann, E. J. Speckmann Institut für Physiologie, Universität, Münster Institut für Experimentelle Epilepsieforschung, Universität, MünsterSearch for more papers by this author J. Walden, J. Walden Psychiatrische Universitätsklinik, FreiburgSearch for more papers by this authorH. Straub, H. Straub Institut für Physiologie, Universität, MünsterSearch for more papers by this authorE. J. Speckmann, E. J. Speckmann Institut für Physiologie, Universität, Münster Institut für Experimentelle Epilepsieforschung, Universität, MünsterSearch for more papers by this author First published: November 1992 https://doi.org/10.1111/j.1600-0404.1992.tb04469.xCitations: 13AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Speckmann EJ, Schulze H, Walden J. Epilepsy and Calcium. Urban Schwar-zenberg, München-Wien-Baltimore 1986b. 2 U Heinemann, M Klee, E Neher, W Singer, (eds.). Calcium electrogenesis and new neuronal functioning. Exp. Brain Res. 1986: Supp. 14. 3 Caspers H, Speckmann EJ, Lehmenkühler A. DC potentials of the cerebralcortex. Seizure activity and changes in gas pressure. Rev. Physiol. Biochem. Pharmacol. 1987: 106: 127– 178. 4 Heinemann, U. Changes in the neuronal microenvironment and epileptiform activity. In: HG. Wieser, EJ. Speckmann, J. Engel (eds.). The epileptic focus. John Libbey, London-Paris 1987: 27– 44. 5 Lücke A, Speckmann EJ, Altrup U, Lehmenkühler A, Walden J. Decrease of free calcium concentration at the outer surface of identified snail neurons during paroxysmal depolarization shifts. Neurosci. Lett. 1990: 112: 190– 3. 6 Speckmann EJ, Walden J, Bingmann D. Contribution of calcium ions to epileptogenesis. Journal of Basic & Clinical Physiol. & Pharmacol. 1990: Vol. 1: 95– 105. 7 Aicardi G, Schwartzkroin PA. Suppression of epileptiform burst discharges in CA3 neurons of rat hippocampal slices by the organic calcium channels blocker, verapamil. Exp. Brain Res. 1990: 81: 288– 296. 8 Bingmann D, Speckmann EJ. Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antagonist flunarizine and verapamil. Exp. Brain Res. 1989: 74: 239– 248. 9 Bingmann D, Speckmann EJ, Baker RE, Ruijter J, de Jong BM. Differential antiepileptic effects of the organic calcium antagonists verapamil and flunarizine in neurons of organotypic neocortical explants from newborn rats. Exp. Brain Res. 1988: 72: 439– 442. 10 Pohl M. Straub H, Speckmann EJ. Low magnesium-induced epileptic discharges in guinea pig hippocampal slices: Depression by the organic calcium antagonist verapamil. Brain Res. 1992: in press. 11 Speckmann EJ. Experimentelle Epilepsieforschung. Wissenschaftliche Buchgesellschaft, Darmstadt 1986a. 12 Straub H, Speckmann EJ, Bingmann D, Walden J. Paroxysmal depolarization shifts induced by bicuculline in CA3 neurons of hippocampal slices: Suppression by the organic calcium antagonist verapamil. Neurosci. Lett. 1990: 111: 99– 101. 13 Straub H, Danz C, Speckmann EJ. Depressive effects of organic calcium ant-agonists on bicuculline induced epileptic activity in hippocampal and neocortical neurons. In: EJ Speckmann and MJ Gutnick (eds.). Epilepsy and Inhibition. Urban & Schwarzenberg. München-Wien-Baltimore 1992a: 255– 270. 14 Walden J, Speckmann EJ. Suppression of recurrent generalized tonic-clonic seizure discharges by intraventricular perfusion of a calcium antagonist. Electroenceph. clin. Neurophysiol. 1988: 69: 353– 362. 15 Walden J, Speckmann EJ, Witte OW. Suppression of focal epileptiform discharges by intraventricular perfusion of focal epileptiform discharges by intraventricular perfusion of a calcium antagonist. Electroenceph. clin. Neurophysiol. 1985: 61: 299– 309. 16 HG Wieser, EJ Speckmann, J. Engel (eds.). The epileptic focus. John Libbey, London-Paris 1987. 17 Witte OW, Speckmann EJ, Walden J. Motor cortical epileptic foci in vivo: Actions of a calcium channel blocker on paroxysmal neuronal depolarizations. Electroenceph. clin. Neurophysiol. 1987: 66: 43– 55. 18 Matsumoto H, Ajmone Marsan C. Cortical cellular phenomena in experimental epilepsy: Interictal manifestations. Exp. Neurol. 1964a: 9: 286– 304. 19 Matsumoto H, Ajmone Marsan, C. Cortical cellular phenomena in experimental epilepsy: Ictal manifestations. Exp. Neurol. 1964b: 9: 305– 326. 20 Goldensohn ES, Purpura DP. Intracellular potentials of cortical neurons during focal epileptogenic discharges. Science 1963: 139: 840– 2. 21 Walden J, Witte OW, Speckmann EJ, Elger CE. Reduction of calcium currents in identified neurons of Helix pomatia: Intracellular injection of D890. Comp. Biochem. Physiol. 1984: 77C: 211– 7. 22 Straub H, Baker RE, Bingmann D, Speckmann EJ. Spontaneously appearing burst discharges in hippocampal and neocortical neurons (in vitro): Suppression by the calcium antagonists verapamil and flunarizine. Pflügers Arch. 1991: 418: Suppl. 1, R14. 23 Moraidis I, Bingmann D, Lehmenkühler A, Speckmann EJ. Caffeine-induced epileptic discharges in CA3 neurons of hippocampal slices of the guinea pig. Neurosci. Lett. 1991: 129: 51– 4. 24 Walden J, Bingmann D, Liu Z, Moraidis I, Düsing R, Grunze H. Calcium antagonistic effects of the antiepileptic and antipsychotic drug carbamazepine. Pflügers Arch. 1992: 420: R35. 25 Walden J, Speckmann EJ, Witte OW. Membrane currents induced by pentylenetetrazol in identified neurons of Helix pomatia. Brain Res. 1988: 473: 294– 305. 26 Avoli M, Louvel J, Pumain R, Olivier A. Seizure-like discharges induced by lowering [Mg2+]o in the human epileptogenic neocortex maintained in vitro. Brain Res. 1987: 417: 199– 203. 27 Straub H, Lücke A, Köhling R, Moskopp D, Pohl M, Wassmann H, Speckmann EJ. Low magnesium induced epileptiform activity in the human neocortex maintained in vitro: Suppression by the organic calcium antagonist verapamil. Journal of Epilepsy, 1992 b: in press. 28 Fröscher W. Medikamentöse Therapie bei Epilepsien. Regelbehandlung und Vorgehen bei Problemfällen. In: J Walden, OW Witte, EJ Speckmann (eds.), Epileptische Anfälle. Springer, Heidelberg-New York-Berlin, 1992: 69– 83. Citing Literature Volume86, IssueS140November 1992Pages 41-46 ReferencesRelatedInformation