Publication Information

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'https://openalex.org/W2091823485', 'https://openalex.org/W2103700658', 'https://openalex.org/W2115270691', 'https://openalex.org/W2123781000', 'https://openalex.org/W2142316927', 'https://openalex.org/W2146488386', 'https://openalex.org/W2150569981', 'https://openalex.org/W2150632173', 'https://openalex.org/W2156179144', 'https://openalex.org/W2165120639', 'https://openalex.org/W2949065936', 'https://openalex.org/W41086465', 'https://openalex.org/W4235721540'], 'related_works': ['https://openalex.org/W4250379661', 'https://openalex.org/W2939998722', 'https://openalex.org/W2620569104', 'https://openalex.org/W2195592873', 'https://openalex.org/W2169750653', 'https://openalex.org/W2078489088', 'https://openalex.org/W2051335601', 'https://openalex.org/W1971782741', 'https://openalex.org/W1969947129', 'https://openalex.org/W1521361692'], 'abstract_inverted_index': {'Proteasomes': [0, 200, 2981, 3736], 'are': [1, 201, 407, 516, 826, 888, 894, 955, 1042, 1047, 1056, 3887, 4196, 4223, 4303], 'the': [2, 49, 54, 66, 92, 115, 118, 133, 138, 143, 149, 159, 168, 174, 178, 186, 190, 202, 249, 254, 266, 292, 315, 318, 333, 338, 343, 349, 359, 368, 374, 378, 386, 390, 410, 449, 567, 575, 709, 748, 752, 756, 841, 850, 869, 891, 897, 958, 966, 978, 983, 1080, 1083, 1234, 1246, 1319, 1322, 1327, 1330, 1383, 1443, 1446, 1454, 1481, 1492, 1500, 1506, 1509, 1515, 1522, 1614, 1624, 1635, 1643, 1711, 1715, 1721, 1732, 1741, 1746, 1757, 1760, 1773, 1790, 1929, 1987, 2034, 2037, 2070, 2080, 2086, 2109, 2128, 2131, 2143, 2157, 2166, 2173, 2180, 2183, 2193, 2392, 2399, 2402, 2457, 2460, 2500, 2580, 2603, 2611, 2623, 2645, 2743, 2915, 2918, 2930, 2933, 3036, 3048, 3051, 3063, 3067, 3074, 3077, 3081, 3098, 3236, 3244, 3309, 3320, 3327, 3330, 3421, 3426, 3465, 3468, 3472, 3500, 3573, 3576, 3583, 3593, 3596, 3619, 3633, 3641, 3711, 3741, 3745, 3759, 3764, 3769, 3773, 3853, 3856, 3872, 3879, 3891, 3929, 3979, 3992, 3995, 3998, 4006, 4017, 4027, 4037, 4081, 4088, 4107, 4114, 4150, 4159, 4176, 4190, 4203, 4218, 4221, 4226, 4243, 4247, 4274, 4277, 4280, 4290, 4301, 4313, 4319, 4355, 4359, 4375], 'primary': [3, 203], 'sites': [4, 75, 94, 120, 135, 145, 155, 176, 188, 204, 275, 294, 320, 335, 345, 355, 376, 388, 739, 843, 893, 954, 1236, 1244, 1448, 1524, 1645, 1713, 2134, 2145, 2176, 2462, 3470, 3598, 3801, 3836, 3849, 4033, 4039, 4083, 4109, 4116, 4178, 4245], 'for': [5, 205, 608, 1485, 1499, 2564, 2956, 3260, 3293, 3297, 3312, 3319, 3632, 3740], 'protein': [6, 206], 'degradation': [7, 207], 'in': [8, 123, 208, 323, 404, 518, 531, 701, 982, 1048, 1321, 1329, 2108, 2120, 2146, 2345, 2361, 2452, 2463, 2490, 2777, 2825, 2909, 2944, 3035, 3235, 3248, 3272, 3425, 3471, 3568, 3592, 3599, 3636, 3884, 4149, 4189, 4216, 4220, 4225, 4230, 4286, 4305, 4312], 'mammalian': [9, 209, 405], 'cells.': [10, 210], 'Each': [11, 211], 'proteasome': [12, 212, 413, 452, 1117, 1250, 2341, 2467, 2940, 3624], 'particle': [13, 213, 503, 853], 'contains': [14, 214, 524, 4067], 'two': [15, 17, 20, 215, 217, 220, 456, 3502, 4031], 'chymotrypsin-like,': [16, 216], 'trypsin-like,': [18, 218], 'and': [19, 36, 219, 236, 453, 521, 566, 706, 882, 886, 969, 1052, 1312, 1347, 1577, 1617, 1749, 1775, 1838, 1841, 1934, 1991, 2042, 2106, 2148, 2154, 2177, 2197, 2199, 2206, 2212, 2221, 2255, 2259, 2298, 2328, 2348, 2363, 2406, 2485, 2574, 2582, 2627, 2638, 2651, 2677, 2856, 2895, 2975, 2990, 3113, 3117, 3295, 3299, 3416, 3484, 3572, 3610, 3699, 3720, 3722, 3729, 3847, 3924, 4030, 4163, 4194, 4323], 'caspase-like': [21, 55, 74, 93, 119, 134, 144, 154, 175, 187, 221, 255, 274, 293, 319, 334, 344, 354, 375, 387, 1447, 1501, 1523, 1615, 1644, 1712, 1722, 1747, 1774, 2144, 2158, 2194, 2461, 3469, 3597, 3760, 3892, 3930, 4028, 4082, 4115, 4177], 'proteolytic': [22, 222, 527, 1794, 4291], 'sites.': [23, 39, 56, 151, 223, 239, 256, 351, 1777, 2031, 2159, 2195, 3893, 4090, 4206], 'Previous': [24, 224], 'studies': [25, 225, 1926, 4208], 'suggest': [26, 226], 'a': [27, 124, 196, 227, 324, 396, 505, 744, 833, 1049, 1307, 1333, 1450, 1630, 1724, 1751, 2092, 2291, 2316, 2491, 2682, 2749, 2819, 2850, 3003, 3021, 3249, 3273, 3317, 3569, 3628], 'complex': [28, 228, 446], 'network': [29, 229], 'of': [30, 53, 68, 91, 102, 114, 132, 142, 173, 181, 185, 230, 253, 268, 291, 302, 314, 332, 342, 373, 381, 385, 402, 448, 509, 704, 736, 747, 751, 755, 849, 961, 971, 1063, 1070, 1082, 1181, 1233, 1245, 1303, 1318, 1326, 1335, 1339, 1342, 1387, 1407, 1410, 1445, 1453, 1495, 1508, 1517, 1642, 1710, 1734, 1745, 1759, 1792, 1931, 1936, 1989, 2036, 2082, 2085, 2095, 2130, 2135, 2142, 2156, 2161, 2168, 2182, 2294, 2302, 2319, 2324, 2340, 2354, 2378, 2401, 2459, 2494, 2503, 2511, 2587, 2591, 2625, 2636, 2672, 2709, 2822, 2852, 2887, 2899, 2903, 2917, 2925, 2932, 2958, 3014, 3025, 3030, 3043, 3050, 3066, 3069, 3076, 3110, 3225, 3233, 3240, 3243, 3246, 3252, 3256, 3326, 3329, 3341, 3423, 3467, 3478, 3495, 3508, 3575, 3585, 3622, 3640, 3744, 3768, 3845, 3852, 3858, 3871, 3882, 3920, 3983, 3994, 3997, 4010, 4019, 4113, 4161, 4173, 4186, 4192, 4200, 4279, 4315, 4326, 4358, 4366], 'allosteric': [31, 231, 1436, 1487, 1610, 1736, 2170], 'interactions': [32, 232, 1771, 2171], 'between': [33, 233, 1772, 2172], 'these': [34, 234, 737, 1040, 1071, 1411, 1496, 1518, 1609, 1638, 1980, 2162, 2498, 3461, 3754, 3835, 3986, 4231], 'catalytic': [35, 235, 757, 870, 953], 'multiple': [37, 237], 'regulatory': [38, 238, 459, 1310, 1355, 1632, 1726, 4205], 'We': [40, 240, 1226], 'used': [41, 241, 624, 1640, 1768, 1984, 2063, 2360, 2451, 2955, 3290, 3418, 3460, 4148], 'positional': [42, 242, 656, 2064, 2117, 2385], 'scanning': [43, 243, 657, 1779, 2065, 2118, 2386, 3336], 'combinatorial': [44, 244, 659, 2388, 3338], 'substrate': [45, 51, 245, 251, 658, 884, 1743, 1780, 2362, 2488, 3234, 3746, 4078, 4233, 4287, 4367], 'libraries': [46, 246, 1781, 1981, 2068, 3339, 3462, 3899], 'to': [47, 108, 117, 195, 247, 308, 317, 395, 874, 973, 1300, 1306, 1313, 1400, 1491, 1521, 1607, 1629, 1720, 1730, 1769, 1784, 1788, 1928, 1985, 2028, 2079, 2125, 2165, 2192, 2397, 2455, 2473, 2578, 2640, 2775, 2880, 3020, 3080, 3262, 3308, 3315, 3419, 3463, 3751, 4016, 4036, 4087, 4106, 4158, 4198, 4202, 4289], 'determine': [48, 248, 2398], 'extended': [50, 250, 1742], 'specificity': [52, 252, 533, 1744, 1791, 1988, 2035, 2129, 2458, 3422, 3466], 'Based': [57, 257], 'on': [58, 258, 957, 2602, 2681, 4152], 'this': [59, 259, 877, 962, 1358, 1486, 1735, 2113, 2346, 2453, 3861, 3885, 4236, 4295], 'analysis,': [60, 260], 'several': [61, 261, 2151, 3241, 4298], 'new': [62, 262], 'substrates': [63, 131, 165, 184, 263, 331, 365, 384, 703, 972, 1232, 1444, 1709, 1933, 2153, 2339, 2593, 2906, 3289, 3435, 3844, 4162, 4174], 'were': [64, 95, 156, 264, 295, 356, 1298, 1605, 1648, 2224, 2257, 2350, 2366, 2471, 2562, 2614, 2653, 2679, 2773, 2878, 2927, 2985, 2993, 3018, 3045, 3227, 3291, 3303, 3414, 3558, 3701, 3725, 3756, 3802, 3837, 4012, 4209, 4282, 4310, 4369], 'synthesized,': [65, 265], 'use': [67, 267, 2100, 2116], 'which': [69, 269, 529, 839, 2742, 4217, 4327], 'confirmed': [70, 270, 2892], 'earlier': [71, 271], 'observations': [72, 272], 'that': [73, 273, 696, 831, 1229, 1438, 1442, 1505, 1620, 1646, 1755, 3591, 3753, 3870, 3918, 4101, 4276], '(often': [76, 276], 'termed': [77, 277, 617], 'postglutamyl': [78, 278, 618, 627], 'peptide': [79, 279, 561, 619, 628, 741, 1064, 1231, 1239, 1752, 2600, 2688, 2771, 2905, 4024], 'hydrolase)': [80, 280], 'cleave': [81, 281, 740, 3432], 'after': [82, 86, 282, 286, 563, 571, 580, 699, 2642, 2741, 3691, 3766], 'aspartates': [83, 283, 700], 'better': [84, 284], 'than': [85, 285, 3904, 4239], 'glutamates.': [87, 287], 'Highly': [88, 288], 'selective': [89, 289, 1932, 2083], 'inhibitors': [90, 141, 290, 341, 1641, 1935, 2084, 2155, 2163, 2889, 3988, 4011], 'also': [96, 296, 2962, 3702, 4076], 'generated.': [97, 297], 'They': [98, 298], 'stimulated': [99, 299, 4171], 'trypsin-like': [100, 179, 300, 379, 568, 1776, 2087, 2175, 2583, 3800, 3848], 'activity': [101, 180, 192, 301, 380, 392, 1456, 1511, 1626, 1717, 2185, 2941, 3931, 4357], 'yeast': [103, 303, 2216, 2991, 3623, 3642], '20': [104, 304, 450, 501, 851, 1044, 1248, 2207, 2465, 2938, 3008, 3496, 3552, 4213], 'S': [105, 305, 412, 451, 458, 502, 852, 1045, 1085, 1249, 1354, 2201, 2208, 2466, 2939, 2960, 3009, 3553, 4214], 'proteasomes': [106, 306, 1046, 1990, 2147, 2202, 2561, 2961, 2992, 3430, 3554, 3600, 3645, 3841, 3874, 3897, 3921, 3984, 4164, 4215, 4360], 'up': [107, 307, 3261], '3-fold': [109, 309], 'but': [110, 183, 310, 383, 693, 2023, 3704, 4363], 'not': [111, 147, 311, 347, 880, 3626, 3867, 3927, 4013, 4181, 4372], 'when': [112, 153, 312, 353], 'binding': [113, 194, 313, 394, 885, 1302, 1516, 1628, 1719, 2191, 4035, 4086, 4199], 'inhibitor': [116, 316, 1754, 1765, 2067, 2364, 3044, 3078, 3245, 3775, 4000], 'was': [121, 321, 1392, 1441, 1489, 1512, 2290, 2306, 2315, 2332, 2507, 2514, 2594, 2712, 2746, 2816, 2847, 2891, 2907, 2942, 2999, 3060, 3094, 3119, 3258, 3270, 3579, 3866, 3989, 4117, 4155], 'prevented': [122, 322], 'mutant': [125, 325], 'carrying': [126, 326], 'an': [127, 327, 875, 1764, 4306], 'uncleaved': [128, 160, 328, 360], 'propeptide.': [129, 329], 'Although': [130, 330], 'allosterically': [136, 336], 'inhibit': [137, 189, 337, 389, 1623, 1714], 'chymotrypsin-like': [139, 150, 169, 191, 339, 350, 369, 391, 558, 1235, 1455, 1510, 1625, 1716, 2184, 2581, 3770, 3846, 4108, 4167], 'activity,': [140, 340], 'do': [146, 346], 'affect': [148, 348], 'Furthermore,': [152, 352], 'occupied': [157, 357, 895], 'by': [158, 193, 358, 393, 409, 896, 977, 1079, 1115, 1143, 1173, 1241, 1332, 1389, 1394, 1514, 1612, 1627, 1718, 1994, 2186, 2630, 2657, 2748, 2818, 2849, 2882, 2893, 2912, 3115, 3305, 3333, 3581, 3758, 3890, 3991, 4001, 4026, 4034, 4080, 4084, 4096, 4175, 4284], 'propeptide': [161, 361, 834], 'or': [162, 362, 455, 1114, 1172, 1352, 1674, 1723, 2372, 2620, 2973, 3040, 3238, 3643, 4003, 4098, 4318], 'inhibitor,': [163, 363, 3808], 'their': [164, 364, 532, 836, 2190, 4240], 'still': [166, 366, 4170], 'inhibited': [167, 367], 'activity.': [170, 370], 'Thus,': [171, 371, 1704, 4183, 4374], 'occupancy': [172, 372], 'stimulates': [177, 377], 'proteasomes,': [182, 382], 'distinct': [197, 397, 1308, 1631, 1725], 'noncatalytic': [198, 398, 1309, 4038, 4089, 4204], 'site.': [199, 399, 1633], 'The': [400, 500, 557, 823, 952, 1061, 2769, 2812, 2844, 2875, 2885, 2923, 2953, 3268, 3288, 3799], 'majority': [401, 3881], 'proteins': [403], 'cells': [406], 'degraded': [408], '26': [411, 2200, 2959], '(1Rock': [414], 'K.L.': [415], 'Gramm': [416], 'C.': [417, 2296, 2828, 2859], 'Rothstein': [418], 'L.': [419, 425, 537, 930, 992, 1125, 1152, 2729, 3649], 'Clark': [420], 'K.': [421, 934, 1557, 1684, 1896], 'Stein': [422], 'R.': [423, 547, 792, 811, 913, 932, 996, 1156, 1212, 2272, 2727, 3201, 3659, 3680], 'Dick': [424], 'Hwang': [426], 'D.': [427, 484, 541, 784, 807, 1000, 1023, 1098, 1160, 1186, 1277, 1363, 1416, 2232, 2784, 3653, 3672, 3780, 3935, 4043, 4122, 4253, 4334], 'Goldberg': [428, 591, 718, 763, 1020, 1095, 1187, 1257, 1278, 1364, 1417, 1463, 1531, 2233, 3442, 3781, 3816, 3936, 3960, 4044, 4123, 4254, 4335], 'A.L.': [429, 592, 719, 764, 1021, 1096, 1188, 1258, 1279, 1365, 1418, 1464, 1532, 2234, 3443, 3782, 3817, 3937, 3961, 4045, 4124, 4255, 4336], 'Cell.': [430, 469, 594, 721, 1025, 1100, 1260, 1466, 1534, 1563, 1690, 3445], '1994;': [431], '78:': [432], '761-771Abstract': [433], 'Full': [434, 473, 475, 598, 600, 725, 727, 771, 773, 1029, 1031, 1104, 1106, 1195, 1197, 1264, 1266, 1286, 1288, 1372, 1374, 1425, 1427, 1470, 1472, 1538, 1540, 1567, 1569, 1595, 1597, 1664, 1666, 1694, 1696, 1828, 1830, 1915, 1917, 1969, 1971, 2013, 2015, 2241, 2243, 2439, 2441, 2548, 2550, 2802, 2804, 3212, 3214, 3375, 3377, 3406, 3449, 3451, 3542, 3544, 3789, 3791, 3824, 3826, 3944, 3946, 3968, 3970, 4052, 4054, 4131, 4133, 4262, 4264, 4343, 4345], 'Text': [435, 474, 476, 599, 601, 726, 728, 772, 774, 1030, 1032, 1105, 1107, 1196, 1198, 1265, 1267, 1287, 1289, 1373, 1375, 1426, 1428, 1471, 1473, 1539, 1541, 1568, 1570, 1596, 1598, 1665, 1667, 1695, 1697, 1829, 1831, 1916, 1918, 1970, 1972, 2014, 2016, 2242, 2244, 2440, 2442, 2549, 2551, 2803, 2805, 3213, 3215, 3376, 3378, 3407, 3450, 3452, 3543, 3545, 3790, 3792, 3825, 3827, 3945, 3947, 3969, 3971, 4053, 4055, 4132, 4134, 4263, 4265, 4344, 4346], 'PDF': [436, 477, 602, 729, 775, 1033, 1108, 1199, 1268, 1290, 1376, 1429, 1474, 1542, 1571, 1599, 1668, 1698, 1832, 1919, 1973, 2017, 2245, 2443, 2552, 2806, 3216, 3379, 3408, 3453, 3546, 3793, 3828, 3948, 3972, 4056, 4135, 4266, 4347], 'PubMed': [437, 478, 495, 552, 603, 688, 730, 776, 797, 818, 863, 924, 947, 1007, 1034, 1109, 1138, 1167, 1200, 1269, 1291, 1377, 1430, 1475, 1543, 1572, 1600, 1669, 1699, 1833, 1859, 1886, 1920, 1974, 2018, 2058, 2246, 2283, 2444, 2553, 2666, 2699, 2736, 2807, 2839, 2870, 3189, 3217, 3380, 3409, 3454, 3547, 3664, 3685, 3794, 3829, 3949, 3973, 4057, 4136, 4267, 4348], 'Scopus': [438, 479, 496, 553, 604, 689, 731, 777, 798, 819, 864, 925, 948, 1008, 1035, 1110, 1139, 1168, 1201, 1222, 1270, 1292, 1378, 1431, 1476, 1544, 1573, 1601, 1670, 1700, 1834, 1860, 1887, 1921, 1975, 2019, 2059, 2247, 2284, 2445, 2554, 2667, 2700, 2737, 2765, 2808, 2840, 2871, 3190, 3218, 3381, 3410, 3455, 3548, 3665, 3686, 3795, 3830, 3950, 3974, 4058, 4137, 4268, 4349], '(2206)': [439], 'Google': [440, 481, 498, 555, 606, 691, 733, 779, 800, 821, 866, 927, 950, 1010, 1037, 1112, 1141, 1170, 1203, 1224, 1272, 1294, 1380, 1433, 1478, 1546, 1575, 1603, 1672, 1702, 1836, 1862, 1889, 1923, 1977, 2021, 2061, 2249, 2286, 2447, 2556, 2669, 2702, 2739, 2767, 2810, 2842, 2873, 3192, 3220, 3383, 3412, 3457, 3550, 3667, 3688, 3797, 3832, 3952, 3976, 4060, 4139, 4270, 4351], 'Scholar).': [441, 499, 556, 734, 822, 867, 951, 1038, 1225, 1295, 1381, 1434, 1479, 1547, 1703, 1924, 1978, 2250, 2287, 2557, 2670, 2703, 2768, 2811, 2843, 2874, 3221, 3551, 3689, 3798, 3833, 3977, 4061, 4140, 4271, 4352], 'This': [442, 610, 2074, 3474, 3588, 3614, 3909], 'large': [443], '(2.4-MDa)': [444], 'ATP-dependent': [445], 'consists': [447], 'one': [454, 3489, 3494], '19': [457, 1084, 1353], 'complexes': [460, 1086, 1119], '(2Baumeister': [461], 'W.': [462, 488, 790, 813, 903, 936, 3678], 'Walz': [463], 'J.': [464, 539, 765, 782, 809, 859, 941, 1189, 1215, 1280, 1366, 1419, 1553, 1589, 1658, 1680, 1822, 1909, 1963, 2003, 2235, 2433, 2542, 2730, 3146, 3154, 3206, 3369, 3392, 3536, 3651, 3670, 3783, 3818, 3938, 3962, 4046, 4125, 4256, 4337], 'Zühl': [465], 'F.': [466, 1849, 1869], 'Seemüller': [467], 'E.': [468, 803, 2693, 2790], '1998;': [470, 944, 3209], '92:': [471], '367-380Abstract': [472], '(1310)': [480], 'Scholar,': [482, 780, 801, 928, 1011, 1204, 1273, 1863, 1890, 3193, 3384, 3668, 3953], '3Voges': [483], 'Zwickl': [485, 787, 3675], 'P.': [486, 788, 1015, 1090, 3676], 'Baumeister': [487, 789, 812, 3677], 'Annu.': [489], 'Rev.': [490], 'Biochem.': [491, 2834, 2865], '1999;': [492, 595, 722, 921, 1261, 1467, 1535, 2280, 3446, 3821, 3965], '68:': [493], '1015-1068Crossref': [494], '(1601)': [497], 'is': [504, 872, 975, 2089, 3476, 3491, 3616, 3911, 4064, 4246], 'hollow': [506], 'cylinder': [507], 'composed': [508, 3477], 'four': [510], 'stacked': [511], 'rings.': [512], 'Two': [513], 'inner': [514, 959], 'β-rings': [515], 'identical': [517], 'subunit': [519], 'composition,': [520], 'each': [522, 2504, 3487], 'β-ring': [523], 'three': [525, 3479, 3563], 'different': [526, 1937, 1995, 3028, 3868], 'sites,': [528, 1502, 2040, 2088, 2584, 4168], 'differ': [530], '(4Groll': [534, 3646], 'M.': [535, 543, 683, 855, 901, 909, 940, 986, 988, 1146, 1148, 1206, 1586, 1655, 1809, 1898, 1906, 1950, 2005, 2047, 2264, 2420, 2529, 2725, 2786, 3178, 3195, 3356, 3523, 3647, 3655], 'Ditzel': [536, 3648], 'Löwe': [538, 808, 3650], 'Stock': [540, 783, 806, 3652, 3671], 'Bochtler': [542, 908, 3654], 'Bartunik': [544, 3656], 'H.': [545, 2757, 2759, 3657], 'Huber': [546, 791, 810, 912, 931, 995, 1155, 1211, 2726, 3658, 3679], 'Nature.': [548, 1134, 3185, 3660], '1997;': [549, 860, 1825, 1966, 2436, 2545, 2696, 3372, 3403, 3539, 3661], '386:': [550, 3662], '463-471Crossref': [551, 3663], '(1951)': [554, 3666], 'site': [559, 569, 577, 613, 1311, 1616, 1748, 3639, 3771, 4029], 'cleaves': [560, 698], 'bonds': [562, 742], 'hydrophobic': [564, 1230, 1304, 1390, 3604, 3717, 4065, 4320], 'residues,': [565, 573, 3696], 'cuts': [570, 578], 'basic': [572], 'whereas': [574, 3499, 3727], 'third': [576], 'preferentially': [579], 'acidic': [581, 1497, 1519, 1621, 2187, 2607, 2632], 'residues': [582, 3605, 3724], '(see': [583], 'Ref.': [584], '5Kisselev': [585], 'A.F.': [586, 713, 760, 1184, 1252, 1275, 1361, 1414, 1458, 1526, 2230, 2788, 3437, 3778, 3811, 3933, 3955, 4041, 4120, 4251, 4332], 'Akopian': [587, 714, 1253, 1459, 1527, 3438, 3812, 3956], 'T.N.': [588, 715, 1254, 1460, 1528, 3439, 3813, 3957], 'Castillo': [589, 716, 1255, 1461, 1529, 3440], 'V.': [590, 717, 1256, 1462, 1530, 3441], 'Mol.': [593, 720, 942, 1024, 1099, 1259, 1465, 1533, 1562, 1689, 3444], '4:': [596, 723, 1262, 1468, 1536, 3404, 3447], '395-402Abstract': [597, 724, 1263, 1469, 1537, 3448], '(235)': [605, 732, 1271, 1477, 1545, 1861, 3456], 'Scholar': [607], 'references).': [609], 'last': [611], '“postacidic”': [612], 'had': [614], 'been': [615, 1983, 2450], 'generally': [616], 'hydrolase': [620], '(PGPH)': [621], '1The': [622], 'abbreviations': [623], 'are:': [625], 'PGPH,': [626], 'hydrolase;': [629], 'AEBSF,': [630], '4-(2-aminoethyl)-benzenesulfonyl': [631], 'fluoride;': [632], 'al,': [633], 'aldehyde;': [634], 'amc,': [635], '7-amido-4-methylcoumarinamide;': [636], 'AMC,': [637], '7-amino-4-methylcoumarin;': [638], 'Boc,': [639], 'tert-butyloxycarbonyl;': [640], 'BrAAP,': [641], 'branched': [642], 'chain': [643], 'amino': [644, 2103, 2358, 3497, 3510, 3694], 'acid-preferring;': [645], 'ex,': [646], 'epoxyketone;': [647], 'Fmoc,': [648], 'N-(9-fluorenyl)methoxycarbonyl;': [649], 'na,': [650], '2-naphthylamide;': [651], 'NLVS,': [652], '4-hydroxy-5-iodo-3-nitrophenylacetyl-Leu-Leu-vinyl': [653], 'sulfone;': [654], 'PS-SCL,': [655], 'libraries;': [660], 'Z,': [661], 'benzyloxycarbonyl;': [662], 'AMP-PNP,': [663, 2974], '5′-adenylyl-β,γ-imidotriphosphate;': [664], 'HPLC,': [665, 2644], 'high': [666], 'pressure': [667], 'liquid': [668], 'chromatography;': [669], 'CHAPS,': [670, 3282], '3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [671], 'acid;': [672], 'OtBu,': [673], 'tert-butoxy;': [674], 'nL,': [675], 'norleucine;': [676], 'PyBOP,': [677], 'benzotriazol-1-yloxytris-pyrrolidinophosphonium': [678], 'hexafluorophosphate;': [679], 'mna,': [680], '4-methoxy-2-naphthylamide.': [681], '(6Orlowski': [682], 'Biochemistry.': [684], '1990;': [685], '29:': [686], '10289-10297Crossref': [687], '(412)': [690], 'Scholar),': [692, 1142, 1171, 2022, 2740, 3458], 'we': [694, 1439, 1503, 1738, 2115, 2138, 3459, 3762, 3914, 4071, 4092, 4293], 'found': [695, 1228, 1402, 4370], 'it': [697, 1705, 2077, 2098, 4169], 'fluorogenic': [702, 2647, 2904], 'caspases': [705, 1797, 1938, 2349, 3424], 'therefore': [707, 1618], 'suggested': [708], 'name': [710], '“caspase-like”': [711], '(5Kisselev': [712, 1251, 1457, 1525, 3436], 'All': [735], 'active': [738, 824, 842, 892, 1243, 2030, 2039, 2133, 3638, 4244], 'via': [743], 'nucleophilic': [745], 'attack': [746], 'hydroxyl': [749], 'group': [750, 2745, 2815, 2846], 'N-terminal': [753, 1340], 'threonine': [754, 871], 'β-subunit': [758], '(7Kisselev': [759], 'Songyang': [761], 'Z.': [762], 'Biol.': [766, 943, 1003, 1163, 1190, 1281, 1367, 1420, 1590, 1659, 1823, 1910, 1964, 2009, 2236, 2434, 2543, 2798, 3207, 3370, 3402, 3537, 3784, 3819, 3939, 3963, 4047, 4126, 4257, 4338], 'Chem.': [767, 1191, 1217, 1282, 1368, 1421, 1591, 1660, 1824, 1911, 1965, 2008, 2237, 2435, 2544, 2797, 3208, 3371, 3401, 3538, 3785, 3820, 3940, 3964, 4048, 4127, 4258, 4339], '2000;': [768, 1004, 1135, 1164, 1219, 1592, 1661, 1856, 1883, 2733, 2762], '275:': [769, 1593, 1662], '14831-14837Abstract': [770], '(107)': [778], '8Löwe': [781, 3669], 'Jap': [785, 3673], 'B.': [786, 3199, 3674], 'Science.': [793, 814, 2337, 3681], '1995;': [794, 815, 2663, 3682], '268:': [795, 816, 3683], '533-539Crossref': [796, 3684], '(1381)': [799, 3687], '9Seemüller': [802], 'Lupas': [804], 'A.': [805, 920, 990, 1013, 1088, 1150, 1882, 1894, 2054, 2299], '579-582Crossref': [817], '(586)': [820], 'subunits': [825], 'generated': [827], 'from': [828, 1315, 2091, 2203, 2215, 2308, 2334, 2351, 2367, 2714, 2929, 2982, 3047, 3097, 3555, 3869], 'larger': [829], 'precursors': [830], 'contain': [832, 3504], 'at': [835, 1397, 2567, 2987, 2995, 3002, 3265, 3707, 3850, 3900, 4242], 'N': [837], 'terminus,': [838], 'block': [840], 'until': [844], 'removed': [845, 2747, 2817, 2848, 4093], 'autocatalytically': [846], 'during': [847], 'assembly': [848], '(10Schmidt': [854], 'Kloetzel': [856], 'P.M.': [857], 'FASEB': [858], '11:': [861], '1235-1243Crossref': [862], '(42)': [865], 'If': [868], 'mutated': [873], 'alanine,': [876], 'autoprocessing': [878], 'does': [879, 3926], 'occur,': [881], 'both': [883, 4325], 'catalysis': [887], 'impossible,': [889], 'since': [890], '8–9-residue-long': [898], 'propeptides': [899], '(11Groll': [900], 'Heinemeyer': [902, 935], 'Jager': [904], 'S.': [905, 919, 1584, 1653, 1815, 1871, 1881, 1956, 2053, 2426, 2535, 2832, 2863, 3362, 3529], 'Ullrich': [906], 'T.': [907, 1807, 1948, 2045, 2418, 2527, 3354, 3388, 3521], 'Wolf': [910, 937], 'D.H.': [911, 938], 'Proc.': [914, 1876, 2048], 'Natl.': [915, 1877, 2049], 'Acad.': [916, 1878, 2050], 'Sci.': [917, 1879, 2051, 2732], 'U.': [918, 1880, 2052], '96:': [922], '10976-10983Crossref': [923], '(242)': [926], '12Ditzel': [929], 'Mann': [933], 'Groll': [939, 2724], '279:': [945], '1187-1191Crossref': [946], '(105)': [949], 'located': [956], 'surface': [960], 'cylindrical': [963], 'particle,': [964], 'within': [965], 'central': [967], 'chamber,': [968, 4292], 'access': [970, 4288], 'them': [974], 'controlled': [976], 'narrow,': [979], 'gated': [980, 1072], 'channels': [981, 1041, 1328, 1412, 4302], 'α-rings': [984, 4222], '(13Groll': [985, 1145], 'Bajorek': [987, 1147], 'Kohler': [989, 1149], 'Moroder': [991, 1151, 2728], 'Rubin': [993, 1153], 'D.M.': [994, 1154, 1805, 1946, 2268, 2416, 2525, 3352, 3519], 'Glickman': [997, 1157], 'M.H.': [998, 1158], 'Finley': [999, 1022, 1097, 1159], 'Nat.': [1001, 1161, 1854], 'Struct.': [1002, 1162], '7:': [1005, 1027, 1102, 1165, 1565, 1692], '1062-1067Crossref': [1006, 1166], '(660)': [1009, 1169], '14Köhler': [1012], 'Cascio': [1014, 1089], 'Leggett': [1016, 1091], 'D.S.': [1017, 1092], 'Woo': [1018, 1093, 3814, 3958], 'K.M.': [1019, 1094, 3815, 3959], '2001;': [1026, 1101, 1564, 1691, 1912, 2010, 2055, 2799], '1143-1152Abstract': [1028, 1103], '(344)': [1036, 1111], 'When': [1039, 3834, 4091, 4141], 'closed,': [1043], 'latent': [1050, 1247, 4212], 'state,': [1051], 'peptides': [1053, 1305, 1391, 1498, 1520, 1622, 2188, 4022], 'added': [1054, 2472, 3019, 4156], 'exogenously': [1055], 'hydrolyzed': [1057], 'only': [1058, 1676, 2101, 4102], 'very': [1059], 'slowly.': [1060], 'rate': [1062], 'hydrolysis': [1065, 1240, 4025, 4079, 4241], 'dramatically': [1066], 'increases': [1067], 'upon': [1068], 'opening': [1069, 1075, 1317, 1325, 1409, 4330], 'channels.': [1073], 'Such': [1074, 1763], 'can': [1076, 1237, 2099, 3431, 4075], 'be': [1077, 1767, 1785], 'triggered': [1078], 'ATPases': [1081], '(14Köhler': [1087], 'Scholar)': [1113, 1576, 1604, 1673, 1837, 2062, 2448, 3413], 'PA28/PA26': [1116], 'activator': [1118], '(15Whitby': [1120], 'F.G.': [1121], 'Masters': [1122], 'E.I.': [1123], 'Kramer': [1124], 'Knowlton': [1126], 'J.R.': [1127, 3132, 3144], 'Yao': [1128], 'Y.': [1129], 'Wang': [1130, 2604], 'C.C.': [1131], 'Hill': [1132, 2297], 'C.P.': [1133], '408:': [1136], '115-120Crossref': [1137], '(423)': [1140], 'mutation': [1144], 'various': [1174], 'chemical': [1175], 'treatments,': [1176], 'such': [1177], 'as': [1178, 2226, 2261, 2516, 2655, 2752, 2779, 3062, 3125, 4147], 'low': [1179, 3738], 'concentrations': [1180, 1398, 3029, 3232, 3242, 4009], 'SDS': [1182, 4317], '(16Kisselev': [1183, 1360, 1413, 2229, 3777, 3932, 4040, 4119, 4250, 4331], 'Kaganovich': [1185, 1276, 1362, 1415, 2231, 3779, 3934, 4042, 4121, 4252, 4333], '2002;': [1192, 1283, 1369, 1422, 2238, 3786, 3941, 4049, 4128, 4259, 4340], '277:': [1193, 1284, 1370, 1423, 2239, 3787, 3942, 4050, 4129, 4260, 4341], '22260-22270Abstract': [1194, 1285, 1371, 1424, 2240, 3788, 3943, 4051, 4130, 4261, 4342], '(156)': [1202, 1293, 1379, 1432, 2248, 3796, 3951, 4059, 4138, 4269, 4350], '17Groll': [1205], 'Kim': [1207, 1554, 1681], 'K.B.': [1208, 1555, 1682], 'Kairies': [1209], 'N.': [1210], 'Crews': [1213, 1560, 1687], 'C.M.': [1214, 1561, 1688], 'Am.': [1216], 'Soc.': [1218], '122:': [1220], '1237-1238Crossref': [1221], '(279)': [1223], 'previously': [1227, 2228, 3916], 'stimulate': [1238, 4023], 'all': [1242, 2592, 2888, 3509, 3562], '16Kisselev': [1274], 'These': [1296, 1925, 4207], 'effects': [1297, 1611], 'shown': [1299, 3917], 'involve': [1301], 'result': [1314], 'peptide-induced': [1316], 'channel': [1320, 4237], 'α-rings,': [1323], 'because': [1324, 2097, 3618, 3913], 'α-ring': [1331], 'variety': [1334], 'treatments': [1336], '(e.g.': [1337], 'deletions': [1338], 'tails': [1341], 'α-subunits,': [1343], 'treatment': [1344, 3919], 'with': [1345, 1349, 2069, 2122, 2381, 2391, 2570, 2616, 3229, 3493, 3561, 3772, 3805, 3922, 3985, 4165, 4211], 'SDS,': [1346], 'association': [1348], 'PA26': [1350, 2289, 2998], 'activators': [1351, 1997], 'complexes)': [1356], 'abolished': [1357], 'activation': [1359, 1386, 4112], 'On': [1382, 1634], 'other': [1384, 1636, 3693, 4032], 'hand,': [1385, 1637], 'proteolysis': [1388], 'reduced': [1393, 4014], 'potassium': [1395], 'ions': [1396], 'similar': [1399, 1490, 4364], 'those': [1401, 2343], 'inside': [1403], 'cells,': [1404], 'through': [1405, 4235], 'inhibition': [1406, 1452, 1488, 1507, 2181, 3314, 3321], 'spontaneous': [1408], 'Another': [1435], 'effect': [1437], 'uncovered': [1440], 'cause': [1449], 'noncompetitive': [1451], 'Because': [1480, 4062], 'K': [1482, 1493, 3012, 3056, 3092, 3101, 3104, 3230, 3323], 'i': [1483, 3013, 3057, 3072, 3085, 3093, 3102], 'value': [1484, 3318], 'm': [1494, 3231], 'concluded': [1504, 1619], 'caused': [1513, 3731], 'However,': [1548], 'Myung': [1549], 'et': [1550, 1579], 'al.': [1551, 1580], '(19Myung': [1552, 1679], 'Lindsten': [1556, 1683], 'Dantuma': [1558, 1685], 'N.P.': [1559, 1686], '411-420Abstract': [1566, 1693], '(106)': [1574, 1701], 'Schmidtke': [1578], '(18Schmidtke': [1581, 1650], 'G.': [1582, 1651, 2721, 3162], 'Emch': [1583, 1652], 'Groettrup': [1585, 1654], 'Holzhutter': [1587, 1656], 'H.G.': [1588, 1657, 3130], '22056-22063Abstract': [1594, 1663], '(79)': [1602, 1671], 'unable': [1606], 'prevent': [1608], 'blocking': [1613], 'investigators': [1639], 'either': [1647, 2617], 'weak': [1649], 'showed': [1675, 3737], 'moderate': [1677], 'selectivity': [1678, 3739, 3859], 'remains': [1706], 'unclear': [1707], 'whether': [1708, 2179, 4073], 'site(s).': [1727], 'In': [1728, 2112, 2558, 3486, 3710, 3749, 3978, 4005], 'order': [1729, 3750], 'study': [1731, 1986, 2454], 'mechanism': [1733], 'inhibition,': [1737], 'here': [1739], 'characterize': [1740, 2456, 3464], 'design': [1750, 1930], 'analogue': [1753], 'matches': [1756], 'sequence': [1758], 'best': [1761], 'substrate.': [1762], 'could': [1766], 'probe': [1770], 'Positional': [1778, 2382], 'have': [1782, 1982, 3915], 'proven': [1783], 'useful': [1786], 'tools': [1787], 'define': [1789, 2126], '“classical”': [1793], 'enzymes': [1795], 'including': [1796], '(20Thornberry': [1798, 1939, 2409, 2518, 3345, 3512], 'N.A.': [1799, 1940, 2276, 2410, 2519, 3128, 3205, 3346, 3400, 3513], 'Rano': [1800, 1941, 2411, 2520, 3347, 3514], 'T.A.': [1801, 1942, 2412, 2521, 3348, 3386, 3515], 'Peterson': [1802, 1943, 2265, 2413, 2522, 3196, 3349, 3389, 3516], 'E.P.': [1803, 1944, 2266, 2414, 2523, 3160, 3197, 3350, 3390, 3517], 'Rasper': [1804, 1945, 2267, 2415, 2524, 3351, 3518], 'Timkey': [1806, 1947, 2417, 2526, 3353, 3387, 3520], 'Garcia-Calvo': [1808, 1949, 2419, 2528, 3355, 3522], 'Houtzager': [1810, 1951, 2421, 2530, 3357, 3524], 'V.M.': [1811, 1952, 2422, 2531, 3358, 3525], 'Nordstrom': [1812, 1953, 2423, 2532, 3359, 3526], 'P.A.': [1813, 1954, 2424, 2533, 3360, 3527], 'Roy': [1814, 1955, 2425, 2534, 3361, 3528], 'Vaillancourt': [1816, 1957, 2269, 2427, 2536, 3363, 3530], 'J.P.': [1817, 1958, 2270, 2428, 2537, 3170, 3364, 3531], 'Chapman': [1818, 1959, 2429, 2538, 3133, 3365, 3397, 3532], 'K.T.': [1819, 1960, 2430, 2539, 3134, 3366, 3398, 3533], 'Nicholson': [1820, 1961, 2273, 2431, 2540, 3202, 3367, 3393, 3534], 'D.W.': [1821, 1962, 2274, 2432, 2541, 3203, 3368, 3394, 3535], '272:': [1826, 1967, 2437, 2546, 3373, 3540], '17907-17911Abstract': [1827, 1968, 2438, 2547, 3374, 3541], '(1852)': [1835, 1976, 2446, 2555, 3382, 3549], 'many': [1839], 'serine': [1840], 'cysteine': [1842], 'proteases': [1843], '(21Backes': [1844], 'B.J.': [1845, 1867, 1900, 2007], 'Harris': [1846], 'J.L.': [1847, 1865, 1892, 1999], 'Leonetti': [1848, 1868], 'Craik': [1850, 1874, 1907], 'C.S.': [1851, 1875, 1908], 'Ellman': [1852, 1872, 1901], 'J.A.': [1853, 1873, 1902, 2755, 3182], 'Biotechnol.': [1855], '18:': [1857], '187-193Crossref': [1858], '22Harris': [1864], 'Backes': [1866, 1899], 'Mahrus': [1870], '97:': [1884], '7754-7759Crossref': [1885], '(476)': [1888], '23Harris': [1891], 'Niles': [1893], 'Burdick': [1895], 'Maffitt': [1897], 'Kuntz': [1903], 'I.': [1904], 'Haak-Frendscho': [1905], '276:': [1913], '34941-34947Abstract': [1914], '(57)': [1922], 'led': [1927, 2078, 2164], 'Recently,': [1979], 'its': [1992], 'modulation': [1993], 'PA28': [1996], '(24Harris': [1998], 'Alper': [2000], 'P.B.': [2001], 'Li': [2002], 'Rechstainer': [2004], 'Bakes': [2006], '8:': [2011, 2800], '1131-1141Abstract': [2012], '(91)': [2020], 'without': [2024], 'assigning': [2025], 'cleavage': [2026, 2608, 2902, 3574, 3734, 4172, 4188], 'patterns': [2027, 4365], 'individual': [2029, 2038, 2132, 2505], 'To': [2032, 4272], 'address': [2033], 'Nazif': [2041], 'Bogyo': [2043, 2046, 2322], '(25Nazif': [2044], '98:': [2056], '2967-2972Crossref': [2057], '(159)': [2060], 'irreversible': [2066, 3774, 3807, 3987], 'vinyl': [2071], 'sulfone': [2072], 'pharmacophore.': [2073], 'approach,': [2075], 'although': [2076], 'development': [2081], 'limited': [2090], 'synthetic': [2093, 2387, 3337], 'point': [2094], 'view,': [2096], '2': [2102], 'acids,': [2104, 3498], 'glutamine': [2105], 'asparagine,': [2107], 'P1': [2110], 'position.': [2111], 'study,': [2114, 3981, 4008], 'libraries,': [2119], 'combination': [2121], 'subunit-selective': [2123], 'inhibitors,': [2124], 'further': [2127], 'proteasome.': [2136], 'Specifically,': [2137], 'defined': [2139, 3492], 'substrate-binding': [2140, 3630], 'preferences': [2141], 'then': [2149, 3095], 'designed': [2150, 2396], 'improved': [2152], 'Application': [2160], 'discovery': [2167], 'novel': [2169], 'caspaseand': [2174], 'resolved': [2178], 'involves': [2189], 'Enzymes': [2196], 'Inhibitors—20': [2198], 'rabbit': [2204, 2983, 3556], 'muscle': [2205, 2984, 3557], 'particles': [2209, 3906], '(wild': [2210], 'type': [2211], 'β1T1A': [2213], 'mutant)': [2214], 'Saccharomyces': [2217], 'cerevisiae': [2218], '(strains': [2219], 'SUB61': [2220], 'MHY1157,': [2222], 'respectively)': [2223], 'purified': [2225, 2260, 2879], 'described': [2227, 2262, 2517, 2656, 2753, 2780, 3126], 'Recombinant': [2251, 2288], 'human': [2252, 2403], 'caspase-1,': [2253, 3111], '-3,': [2254, 3112], '-8': [2256, 3114], 'produced': [2258], '(26Garcia-Calvo': [2263], 'Zamboni': [2271], 'Thornberry': [2275, 3204, 3399], 'Cell': [2277], 'Death': [2278], 'Differ.': [2279], '6:': [2281, 2734], '362-369Crossref': [2282], '(195)': [2285], 'kind': [2292, 2317], 'gift': [2293, 2318], 'Drs.': [2295], 'Duff': [2300], '(University': [2301, 2323], 'Utah).': [2303], 'YU102': [2304], '(Ac-GPFL-ex)': [2305], 'purchased': [2307, 2333], 'Affinity': [2309], 'Research': [2310], 'Products': [2311], '(Exeter,': [2312], 'UK).': [2313], 'NLVS': [2314, 2573, 3776, 3923, 4063, 4074, 4095, 4103, 4144, 4193, 4201], 'Dr.': [2320], 'Matt': [2321], 'California': [2325], 'San': [2326], 'Francisco),': [2327], 'AEBSF': [2329, 2577, 3809, 3925, 4195], '(Pefablock': [2330], 'SC)': [2331], 'Roche': [2335], 'Applied': [2336], 'Fluorogenic': [2338], '(except': [2342], 'synthesized': [2344, 2595, 2680, 2890], 'study)': [2347], 'Bachem': [2352], '(King': [2353], 'Prussia,': [2355], 'PA).': [2356], 'Protected': [2357], 'acids': [2359, 3511], 'synthesis': [2365, 2601], 'Calbiochem-Novabiochem': [2368], '(La': [2369], 'Jolla,': [2370], 'CA)': [2371], 'Advanced': [2373], 'ChemTech': [2374], '(Louisville,': [2375], 'KY).': [2376], 'Analysis': [2377], 'Proteasome': [2379, 2900], 'Specificity': [2380, 3328], 'Scanning': [2383], 'Libraries—A': [2384], 'library': [2389, 3862, 3886, 4187], '(PS-SCL)': [2390, 3340], 'general': [2393, 3342], 'structure': [2394, 2886, 3343], 'Ac-X-X-X-Asp-amc': [2395, 3344], 'specificities': [2400], 'caspase': [2404, 3434], 'family': [2405], 'Granzyme': [2407], 'B': [2408], 'has': [2449], 'proteasomes.': [2464, 3010, 3473], 'samples': [2468, 3566], '(3': [2469], 'μg/well)': [2470], 'reaction': [2474, 2919, 2926, 2935, 3052], 'mixtures': [2475, 3507], 'containing': [2476, 3027, 3275], '50': [2477, 2945, 2976], 'mm': [2478, 2483, 2576, 2946, 2951, 2965, 2968, 2971, 3277, 3284], 'Tris-HCl,': [2479, 2947], 'pH': [2480, 2948, 3286], '7.5,': [2481, 2949], '1': [2482, 2571, 2950, 3087, 3263, 4142], 'dithiothreitol,': [2484, 3285], '100': [2486, 2495, 3022, 3253, 3276], 'μm': [2487, 2572, 3023, 4143], 'mix': [2489], 'total': [2492, 3250], 'volume': [2493, 3251], 'μl.': [2496, 3254], 'Under': [2497], 'conditions,': [2499], 'final': [2501, 2631], 'concentration': [2502, 3075, 4146], 'compound': [2506], '∼0.25': [2508], 'μm.': [2509], 'Production': [2510], '7-amino-4-methylcoumarin': [2512], '(AMC)': [2513], 'monitored': [2515, 3120, 3259], 'some': [2559], 'experiments,': [2560], 'preincubated': [2563], '30': [2565, 2996], 'min': [2566], 'room': [2568, 3266], 'temperature': [2569], '0.5': [2575, 2970], 'inactivate': [2579], 'respectively.': [2585], 'Synthesis': [2586, 2671], 'Substrates—The': [2588], 'P4-P2': [2589, 2612, 2770], 'portion': [2590], 'using': [2596, 2685, 2716, 3121], 'Fmoc-based': [2597, 2687], 'solid': [2598, 2683], 'phase': [2599, 2684], 'resin.': [2605], 'After': [2606], '(trifluoroacetic': [2609], 'acid/CH2Cl2),': [2610], 'portions': [2613], 'condensed': [2615], 'Asp(OtBu)-amc,': [2618, 2649], 'Glu(OtBu)-amc,': [2619, 2650], 'Leu-amc': [2621, 2652], 'under': [2622, 4297], 'agency': [2624], 'PyBOP': [2626], 'diisopropylethylamine,': [2628], 'followed': [2629, 3580, 3990], 'deprotection': [2633], '(in': [2634], 'case': [2635], 'Asp': [2637, 3728], 'Glu)': [2639], 'give,': [2641], 'preparative': [2643, 2883], 'desired': [2646], 'substrates.': [2648, 4020], 'prepared': [2654, 2713], 'Knight': [2658], '(27Knight': [2659], 'C.G.': [2660], 'Methods': [2661, 2694], 'Enzymol.': [2662, 2695], '248:': [2664], '18-34Crossref': [2665], '(96)': [2668], 'Peptide': [2673, 3015], 'Aldehyde': [2674, 3016], 'Inhibitors—Peptides': [2675], 'Ac-APnL': [2676], 'Z-PnL': [2678], 'standard': [2686, 3433, 3843], 'chemistry': [2689], '(28Wellings': [2690], 'D.A.': [2691], 'Atherton': [2692], '289:': [2697], '44-67Crossref': [2698], '(241)': [2701], 'A': [2704], 'fully': [2705], 'protected': [2706], 'semicarbazone': [2707, 2845], 'derivative': [2708], 'Asp-al,': [2710], 'Fmoc-Asp(OtBu)-semicarbazone,': [2711], 'Fmoc-Asp(OtBu)-COOH': [2715], 'Weinreb': [2717], 'amide': [2718], 'methodology': [2719], '(29Loidl': [2720], 'Musiol': [2722], 'H.J.': [2723], 'Pept.': [2731], '36-46Crossref': [2735], '(30)': [2738], 'Fmoc': [2744], '1,8-diazabicyclo[5.4.0]undec-7-ene/octanethiol': [2750], 'mixture': [2751, 2851, 4160], '(30Sheppeck': [2754], 'Kar': [2756], 'Hong': [2758], 'Tetrahedron': [2760], 'Lett.': [2761], '41:': [2763], '5329-5333Crossref': [2764], '(65)': [2766], 'fragments': [2772], 'coupled': [2774], 'Asp(OtBu)-semicarbazone': [2776], 'solution': [2778, 2821, 3024], '(31Kessler': [2781], 'B.M.': [2782], 'Tortorella': [2783], 'Altun': [2785], 'Kisselev': [2787], 'Fiebiger': [2789], 'Hekking': [2791], 'B.G.': [2792], 'Ploegh': [2793], 'H.L.': [2794], 'Overkleeft': [2795], 'H.S.': [2796], '913-929Abstract': [2801], '(149)': [2809], 'tBu': [2813], 'protecting': [2814], '25%': [2820], 'trifluoroacetic': [2823], 'acid': [2824, 3695], 'dichloromethane': [2826], '(32Cardozo': [2827, 2858], 'Chen': [2829, 2860], 'W.E.': [2830, 2861], 'Wilk': [2831, 2862], 'Arch.': [2833, 2864], 'Biophys.': [2835, 2866], '1996;': [2836, 2867], '334:': [2837, 2868], '113-120Crossref': [2838, 2869], '(17)': [2841, 2872], 'methanol,': [2853], 'acetic': [2854], 'acid,': [2855], 'formaldehyde': [2857], 'resulting': [2876, 2934], 'aldehydes': [2877], 'homogeneity': [2881], 'HPLC.': [2884], 'NMR': [2894], 'mass': [2896], 'spectrometry.': [2897], 'Assays': [2898], 'Activity—The': [2901], 'measured': [2908], '96-well': [2910, 3570], 'plates': [2911], 'continuously': [2913], 'monitoring': [2914, 3582], 'fluorescence': [2916, 3584], 'product': [2920], '(free': [2921], 'AMC).': [2922], 'rates': [2924, 3034, 3302, 3903, 4185], 'determined': [2928, 3046, 3061, 3096], 'slopes': [2931, 3049], 'progress': [2936, 3053], 'curves.': [2937, 3054], 'assayed': [2943, 2986, 2994], 'dithiothreitol.': [2952], 'buffer': [2954, 3274], 'assays': [2957, 3124], 'contained': [2963], '40': [2964], 'KCl,': [2966], '5': [2967], 'MgCl2,': [2969], 'ATP': [2972], 'μg/ml': [2977], 'bovine': [2978], 'serum': [2979], 'albumin.': [2980], '37': [2988], '°C,': [2989], '°C.': [2997], 'always': [3000], 'present': [3001, 4007], '4-fold': [3004], 'molar': [3005], 'excess': [3006, 3996, 4094], 'over': [3007], 'Measuring': [3011], 'Inhibitors—Proteasomes': [3017], 'Ac-nLPnLD-amc': [3026], 'inhibitors.': [3031], 'Steady': [3032], 'state': [3033], 'presence': [3037, 3239, 4191, 4314], '(V': [3038], 'i)': [3039], 'absence': [3041, 3237], '(Vo)': [3042], 'Apparent': [3055], '(K': [3058], 'i(app))': [3059], 'reciprocal': [3064], 'slope': [3065], 'plot': [3068], 'V': [3070, 3083], 'o/V': [3071, 3084], 'against': [3073, 3860], 'according': [3079], 'equation': [3082, 3311], '=': [3086, 3103], '+': [3088, 3106], '[S]/K': [3089, 3107], 'i(app).': [3090], 'True': [3091], 'following': [3099], 'equation:': [3100], 'i(app)/(1': [3105], 'm).': [3108], 'Inhibition': [3109], 'Z-PnLD-al': [3116], 'Ac-APnLD-al': [3118], 'continuous': [3122], 'fluorometric': [3123], '(33Thornberry': [3127], 'Bull': [3129], 'Calaycay': [3131], 'Howard': [3135], 'A.D.': [3136], 'Kostura': [3137], 'M.J.': [3138, 3184], 'Miller': [3139], 'D.K.': [3140], 'Molineaux': [3141], 'S.M.': [3142, 3166], 'Weidner': [3143], 'Aunis': [3145], 'Elliston': [3147], 'K.O.': [3148], 'Ayala': [3149], 'J.M.': [3150], 'Casano': [3151], 'F.J.': [3152], 'Chin': [3153], 'Ding': [3155], 'G.J.-F.': [3156], 'Egger': [3157], 'L.A.': [3158], 'Gafney': [3159], 'Limjuco': [3161], 'Palyha': [3163], 'O.C.': [3164], 'Raju': [3165], 'Rolando': [3167], 'A.M.': [3168], 'Salley': [3169], 'Yamin': [3171], 'T.-T.': [3172], 'Lee': [3173], 'T.D.': [3174], 'Shively': [3175], 'J.E.': [3176], 'MacCross': [3177], 'Mumford': [3179], 'R.A.': [3180], 'Schmidt': [3181], 'Tocci': [3183], '1992;': [3186], '356:': [3187], '768-774Crossref': [3188], '(2232)': [3191], '34Garcia-Calvo': [3194], 'Leiting': [3198], 'Ruel': [3200], '273:': [3210], '32608-32613Abstract': [3211], '(849)': [3219], 'Briefly,': [3222], 'appropriate': [3223], 'dilutions': [3224], 'enzyme': [3226], 'combined': [3228], 'interest,': [3247], 'Liberation': [3255], 'AMC': [3257], 'h': [3264], 'temperature.': [3267], 'assay': [3269], 'conducted': [3271], 'HEPES,': [3278], '10%': [3279], 'sucrose,': [3280], '0.1%': [3281], '10': [3283], '7.5.': [3287], 'Ac-WEHD-amc': [3292], 'caspase-1': [3294], 'Ac-DEVD-amc': [3296], 'caspase-3': [3298], 'caspase-8.': [3300], 'Reaction': [3301], 'fit': [3304], 'nonlinear': [3306], 'regression': [3307], 'Michaelis-Menten': [3310], 'competitive': [3313], 'obtain': [3316], 'constant': [3322], 'i.': [3324], 'Characterization': [3325], 'Caspase-like': [3331], 'Site': [3332], 'Position-scanning': [3334], 'Libraries—Positional': [3335], '35Rano': [3385], 'Rotonda': [3391], 'Becker': [3395], 'J.W.': [3396], '149-155Abstract': [3405], '(239)': [3411], 'developed': [3415], 'successfully': [3417], 'map': [3420], 'P2–P4': [3427], 'positions.': [3428], 'Since': [3429], 'PS-SCL': [3475], 'separate': [3480], 'sublibraries': [3481, 3564], '(P2,': [3482], 'P3,': [3483], 'P4).': [3485], 'sublibrary,': [3488], 'position': [3490, 3713, 3743], 'remaining': [3501], 'positions': [3503], 'approximately': [3505], 'equimolar': [3506], 'incubated': [3559], 'simultaneously': [3560, 3803], '(20': [3565], 'each)': [3567], 'plate,': [3571], 'Asp-amc': [3577], 'bond': [3578], 'released': [3586], 'AMC.': [3587], 'analysis': [3589, 4296], 'revealed': [3590], 'P2': [3594, 3634], 'position,': [3595], 'strongly': [3601], 'prefer': [3602], 'bulky': [3603], '(Nle,': [3606], 'Phe,': [3607], 'Trp,': [3608], 'Tyr,': [3609], 'Leu)': [3611], '(Fig.': [3612, 3714, 3747, 3863, 3875, 3907], '1a).': [3613], 'finding': [3615], 'surprising,': [3617, 3912], 'x-ray': [3620], 'diffraction': [3621], 'did': [3625], 'reveal': [3627], 'pronounced': [3629], 'pocket': [3631], 'residue': [3635], 'any': [3637], 'archaeal': [3644], 'Cleavages': [3690], 'most': [3692], 'except': [3697], 'Pro': [3698], 'Asp,': [3700], 'observed,': [3703], 'they': [3705], 'occurred': [3706], 'lower': [3708, 3733], 'rates.': [3709, 3735], 'P3': [3712], '1b),': [3715], 'nonaromatic': [3716], '(Leu,': [3718], 'Nle,': [3719], 'Pro)': [3721], 'Ala': [3723], 'preferred,': [3726], 'Lys': [3730], 'significantly': [3732], 'P4': [3742], '1c).': [3748], 'confirm': [3752], 'cleavages': [3755, 3883], 'performed': [3757, 3889, 4210, 4311], 'site,': [3761], 'repeated': [3763, 4294], 'screen': [3765, 4281], 'inactivation': [3767], 'inactivated': [3804], 'another': [3806], '(36Kisselev': [3810], '274:': [3822, 3966], '3363-3371Abstract': [3823, 3967], '(461)': [3831, 3975], 'inactive': [3838], '(NLVSand': [3839], 'AEBSF-treated': [3840, 3896], 'cleaved': [3842, 3898], '2–5%': [3851], 'control': [3854, 3873, 3905], 'rates),': [3855], 'pattern': [3857], '1,': [3864, 3876], 'd–f)': [3865], 'a–c).': [3877], 'Therefore,': [3878], 'great': [3880], 'indeed': [3888], 'Interestingly,': [3894], 'NLVSand': [3895], '2-fold': [3901, 4179], 'higher': [3902], '1).': [3908], 'observation': [3910], 'enhance': [3928, 4077], '36Kisselev': [3954], 'previous': [3980], 'preincubation': [3982], 'removal': [3993], 'unreacted': [3999], 'dilution': [4002, 4097], 'dialysis.': [4004], 'prior': [4015], 'addition': [4018], 'Hydrophobic': [4021], '(it': [4066], '3': [4068], 'leucine': [4069], 'residues),': [4070], 'tested': [4072], 'reversible': [4085], 'dialysis': [4099], 'so': [4100], 'irreversibly': [4104], 'attached': [4105], 'remained,': [4110], 'no': [4111], 'observed': [4118], '(same': [4145], 'experiments': [4151], 'Fig.': [4153], '1)': [4154], 'back': [4157], 'blocked': [4166], '(data': [4180, 4371], 'shown).': [4182, 4373], 'enhanced': [4184], 'due': [4197], 'gates': [4219], 'largely': [4224], 'closed': [4227], 'conformation.': [4228], 'Consequently,': [4229], 'particles,': [4232], 'entry': [4234], 'rather': [4238], 'rate-limiting': [4248], 'step': [4249], 'exclude': [4273], 'possibility': [4275], 'results': [4278], 'affected': [4283], 'difference': [4285], 'conditions': [4299], 'where': [4300], 'mainly': [4304], 'open': [4307], 'state.': [4308], 'Screens': [4309], '0.01%': [4316], 'peptides,': [4321], 'Suc-FLF-mna': [4322], 'Suc-LLVY-mna,': [4324], 'trigger': [4328], 'gate': [4329], 'As': [4353], 'expected,': [4354], 'overall': [4356], 'increased': [4361], 'considerably,': [4362], 'preference': [4368], 'original': [4376], 's': [4377]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2106906885', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-14T10:48:35.502805', 'created_date': '2016-06-24'}