Publication Information

{'id': 'https://openalex.org/W2106845528', 'doi': 'https://doi.org/10.1074/mcp.r500009-mcp200', 'title': 'Antibody-based Proteomics for Human Tissue Profiling', 'display_name': 'Antibody-based Proteomics for Human Tissue Profiling', 'publication_year': 2005, 'publication_date': '2005-02-06', 'ids': {'openalex': 'https://openalex.org/W2106845528', 'doi': 'https://doi.org/10.1074/mcp.r500009-mcp200', 'mag': '2106845528', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15695805'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.r500009-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620341633/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.mcponline.org/article/S1535947620341633/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060241561', 'display_name': 'Mathias Uhlén', 'orcid': 'https://orcid.org/0000-0002-4858-8056'}, 'institutions': [{'id': 'https://openalex.org/I86987016', 'display_name': 'KTH Royal Institute of Technology', 'ror': 'https://ror.org/026vcq606', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I86987016']}, {'id': 'https://openalex.org/I4210135511', 'display_name': 'AlbaNova', 'ror': 'https://ror.org/044kkfr75', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210135511']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Mathias Uhlen', 'raw_affiliation_strings': ['Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, SE-10691 Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, SE-10691 Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I86987016', 'https://openalex.org/I4210135511']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005639182', 'display_name': 'Fredrik Pontén', 'orcid': 'https://orcid.org/0000-0003-0703-3940'}, 'institutions': [{'id': 'https://openalex.org/I123387679', 'display_name': 'Uppsala University', 'ror': 'https://ror.org/048a87296', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I123387679']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Fredrik Ponten', 'raw_affiliation_strings': ['Department of Genetics and Pathology, Rudbeck Laboratory, SE-751 85 Uppsala University, Uppsala, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics and Pathology, Rudbeck Laboratory, SE-751 85 Uppsala University, Uppsala, Sweden', 'institution_ids': ['https://openalex.org/I123387679']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 7.323, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 302, 'citation_normalized_percentile': {'value': 0.997927, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '4', 'issue': '4', 'first_page': '384', 'last_page': '393'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12867', 'display_name': 'Advanced Biosensing Techniques and Applications', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10519', 'display_name': 'Advanced Proteomics Techniques and Applications', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/human-protein-atlas', 'display_name': 'Human Protein Atlas', 'score': 0.76640344}, {'id': 'https://openalex.org/keywords/proteome', 'display_name': 'Proteome', 'score': 0.7427775}, {'id': 'https://openalex.org/keywords/human-proteome-project', 'display_name': 'Human proteome project', 'score': 0.6688405}], 'concepts': [{'id': 'https://openalex.org/C158163496', 'wikidata': 'https://www.wikidata.org/wiki/Q5937310', 'display_name': 'Human Protein Atlas', 'level': 4, 'score': 0.76640344}, {'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.76172584}, {'id': 'https://openalex.org/C104397665', 'wikidata': 'https://www.wikidata.org/wiki/Q860947', 'display_name': 'Proteome', 'level': 2, 'score': 0.7427775}, {'id': 'https://openalex.org/C94795543', 'wikidata': 'https://www.wikidata.org/wiki/Q3813754', 'display_name': 'Human proteome project', 'level': 4, 'score': 0.6688405}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.63770175}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.564385}, {'id': 'https://openalex.org/C80311884', 'wikidata': 'https://www.wikidata.org/wiki/Q7268939', 'display_name': 'Quantitative proteomics', 'level': 4, 'score': 0.50611776}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48003092}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.41531354}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32911396}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3226179}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.10777497}, {'id': 'https://openalex.org/C6856738', 'wikidata': 'https://www.wikidata.org/wiki/Q331672', 'display_name': 'Protein expression', 'level': 3, 'score': 0.08186099}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07601714}], 'mesh': [{'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040081', 'descriptor_name': 'Protein Array Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014018', 'descriptor_name': 'Tissue Distribution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.r500009-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620341633/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15695805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.r500009-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620341633/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W116062262', 'https://openalex.org/W12235790', 'https://openalex.org/W1527752391', 'https://openalex.org/W1556472699', 'https://openalex.org/W1965942536', 'https://openalex.org/W1966330633', 'https://openalex.org/W1974274123', 'https://openalex.org/W1977103034', 'https://openalex.org/W1979183493', 'https://openalex.org/W1980308557', 'https://openalex.org/W1985230042', 'https://openalex.org/W1985248137', 'https://openalex.org/W1993970782', 'https://openalex.org/W1995724639', 'https://openalex.org/W1996019038', 'https://openalex.org/W1996298591', 'https://openalex.org/W1998412423', 'https://openalex.org/W1999463736', 'https://openalex.org/W2001394491', 'https://openalex.org/W2003470884', 'https://openalex.org/W2003593782', 'https://openalex.org/W2004841938', 'https://openalex.org/W2008292129', 'https://openalex.org/W2014833685', 'https://openalex.org/W2020175044', 'https://openalex.org/W2024514006', 'https://openalex.org/W2024707673', 'https://openalex.org/W2030522563', 'https://openalex.org/W2030810507', 'https://openalex.org/W2033303857', 'https://openalex.org/W2039891585', 'https://openalex.org/W2043335299', 'https://openalex.org/W2044503822', 'https://openalex.org/W2048576415', 'https://openalex.org/W2052567922', 'https://openalex.org/W2053073103', 'https://openalex.org/W2061307153', 'https://openalex.org/W2070564797', 'https://openalex.org/W2073848242', 'https://openalex.org/W2082516011', 'https://openalex.org/W2084639234', 'https://openalex.org/W2087810003', 'https://openalex.org/W2101871915', 'https://openalex.org/W2105131673', 'https://openalex.org/W2108796583', 'https://openalex.org/W2113085085', 'https://openalex.org/W2114522205', 'https://openalex.org/W2125700332', 'https://openalex.org/W2129507580', 'https://openalex.org/W2135098184', 'https://openalex.org/W2136445320', 'https://openalex.org/W2165384556', 'https://openalex.org/W2168203442', 'https://openalex.org/W2172028877', 'https://openalex.org/W2406396923', 'https://openalex.org/W4243050179'], 'related_works': ['https://openalex.org/W4232403872', 'https://openalex.org/W3092794487', 'https://openalex.org/W2885268310', 'https://openalex.org/W2510235409', 'https://openalex.org/W2347437365', 'https://openalex.org/W2234991979', 'https://openalex.org/W2106414650', 'https://openalex.org/W2094752534', 'https://openalex.org/W2025055488', 'https://openalex.org/W1982829397'], 'abstract_inverted_index': {'Here,': [0, 113], 'we': [1, 114, 482], 'describe': [2, 115], 'the': [3, 9, 17, 75, 88, 116, 122, 130, 188, 201, 231, 238, 277, 288, 364, 409, 485, 491, 525, 539, 547, 557, 597, 600, 609, 615, 650, 682, 692, 703, 729, 733, 739, 807, 873, 885, 891, 903, 916, 931, 934, 1031, 1056, 1060, 1069, 1075, 1107, 1127, 1136, 1203, 1210, 1275, 1304, 1312, 1316, 1334, 1338, 1341, 1344, 1436, 1443, 1502, 1520, 1527, 1547, 1566, 1581, 1595, 1603, 1620, 1713, 1840, 1863, 1877, 1898, 1930, 1987, 2071, 2138, 2176, 2225, 2262, 2281, 2288, 2377, 2388, 2397, 2401, 2442, 2518, 2674, 2779, 2850, 2874, 2888, 2905, 3094, 3102, 3109, 3160, 3170, 3266, 3319, 3344, 3382, 3421, 3438, 3461, 3510, 3533, 3540, 3584, 3602, 3622, 3787, 3907, 3913, 3937, 3951, 3964, 4038, 4140, 4145], 'use': [4, 76, 117, 189, 281, 509, 814, 1026, 1339, 1579, 2177, 2272, 2391, 2400, 2443, 2454, 2576, 2748, 2818, 2889, 2909, 3422], 'of': [5, 11, 27, 34, 60, 77, 104, 118, 124, 140, 147, 173, 190, 217, 233, 282, 316, 366, 408, 412, 420, 430, 463, 493, 497, 506, 510, 527, 538, 542, 549, 553, 559, 567, 599, 614, 623, 633, 662, 684, 705, 741, 751, 778, 794, 815, 834, 872, 905, 922, 948, 1011, 1027, 1071, 1077, 1082, 1120, 1129, 1142, 1147, 1250, 1274, 1291, 1299, 1306, 1323, 1333, 1340, 1355, 1368, 1420, 1438, 1442, 1504, 1522, 1568, 1578, 1605, 1610, 1617, 1625, 1628, 1635, 1654, 1667, 1686, 1698, 1703, 1715, 1824, 1843, 1876, 1880, 1893, 1960, 1981, 2070, 2166, 2178, 2189, 2205, 2244, 2273, 2277, 2283, 2287, 2300, 2311, 2331, 2360, 2369, 2384, 2412, 2414, 2419, 2438, 2441, 2444, 2474, 2504, 2515, 2520, 2573, 2577, 2605, 2644, 2706, 2728, 2749, 2778, 2829, 2835, 2839, 2853, 2860, 2869, 2890, 2901, 2910, 2920, 2954, 2964, 2994, 3029, 3039, 3049, 3082, 3087, 3105, 3127, 3145, 3159, 3253, 3285, 3315, 3323, 3330, 3334, 3384, 3412, 3420, 3423, 3437, 3441, 3518, 3567, 3583, 3589, 3717, 3758, 3776, 3783, 3789, 3815, 3824, 3833, 3869, 3876, 3899, 3909, 3933, 3950, 4028, 4035, 4040, 4043, 4047, 4085, 4092, 4134, 4147, 4204], 'antibody-based': [6, 119, 1658, 1829, 2249, 2976], 'proteomics': [7, 120, 1006, 1415, 1830, 2250, 2978, 4192], 'involving': [8, 121, 1853], 'generation': [10, 123, 232, 279, 492, 545, 558, 1070, 1521, 1567, 4146], 'protein-specific': [12, 125, 234, 283], 'antibodies': [13, 21, 78, 126, 134, 191, 235, 284, 875, 914, 925, 1351, 1618, 1655, 1662, 1679, 1756, 1801, 1827, 1865, 1968, 2092, 2099, 2247, 2289, 2323, 2646, 3414], 'to': [14, 90, 127, 203, 236, 258, 285, 313, 328, 513, 607, 700, 806, 912, 963, 967, 1064, 1156, 1190, 1230, 1295, 1330, 1348, 1484, 1516, 1530, 1565, 1583, 1642, 1739, 1944, 1966, 2007, 2093, 2100, 2291, 2351, 2353, 2399, 2417, 2453, 2546, 2570, 2726, 2817, 2822, 2912, 3100, 3143, 3204, 3398, 3434, 3681, 3684, 3799, 3851, 3926, 3981, 3993, 4018, 4065, 4176, 4182, 4194], 'functionally': [15, 128, 286], 'explore': [16, 129, 237, 287], 'human': [18, 105, 131, 218, 239, 465, 1017, 1335, 1345, 1426, 1505, 3044, 3095, 3110, 3210, 3487, 3746, 4210], 'proteome.': [19, 132, 289], 'The': [20, 133, 508, 591, 792, 813, 825, 845, 1025, 1165, 1269, 1553, 1571, 1598, 2308, 2367, 2544, 2575, 2613, 2776, 2812, 2837, 2908, 2962, 3120, 3292, 3393, 3450, 3628, 3774, 3920], 'can': [22, 135, 292, 358, 571, 678, 837, 1045, 1052, 1213, 1970, 2172, 2732, 2796, 3401, 3639, 3657, 3667, 3705, 3940, 3953, 4022, 4062, 4163], 'be': [23, 83, 136, 196, 293, 359, 520, 572, 679, 811, 839, 900, 1046, 1053, 1214, 1231, 1971, 2173, 2733, 2797, 3033, 3402, 3640, 3659, 3668, 3706, 3941, 3954, 4019, 4023, 4063, 4164], 'used': [24, 137, 401, 1054, 1169, 1206, 1453, 1656, 1933, 1972, 2117, 2462, 2482, 2872, 3203, 3403, 3707, 3942], 'for': [25, 40, 48, 58, 67, 79, 98, 138, 153, 161, 171, 180, 192, 211, 230, 310, 363, 402, 460, 490, 532, 556, 738, 951, 1007, 1037, 1055, 1068, 1080, 1109, 1138, 1170, 1321, 1371, 1416, 1492, 1519, 1546, 1614, 1644, 1657, 1828, 1850, 1922, 2015, 2163, 2248, 2379, 2390, 2403, 2435, 2456, 2458, 2463, 2469, 2471, 2477, 2483, 2500, 2517, 2594, 2620, 2640, 2702, 2952, 2974, 2990, 3072, 3157, 3194, 3233, 3282, 3289, 3297, 3326, 3351, 3360, 3368, 3377, 3404, 3430, 3546, 3643, 3655, 3670, 3708, 3755, 3811, 3855, 3890, 3906, 3943, 4032, 4089, 4109, 4153, 4190], 'analysis': [26, 81, 139, 194, 345, 2394, 3028, 3277, 3803, 3807, 3832, 3843, 3908, 3932, 3946, 4155], 'corresponding': [28, 141, 907, 1294], 'proteins': [29, 62, 106, 142, 175, 219, 414, 421, 433, 436, 466, 470, 624, 636, 639, 725, 1084, 1227, 1332, 1525, 1854, 1988, 2123, 2551, 3442, 3452, 3508, 3995, 4017, 4205], 'in': [30, 107, 143, 220, 295, 302, 305, 369, 422, 471, 603, 625, 721, 784, 841, 879, 915, 929, 1016, 1216, 1375, 1425, 1594, 1760, 1856, 1866, 1935, 1941, 1992, 2072, 2139, 2296, 2408, 2424, 2491, 2501, 2508, 2535, 2582, 2590, 2609, 2666, 2723, 2739, 2765, 2787, 2847, 2873, 2904, 2923, 2932, 3077, 3187, 3209, 3238, 3270, 3337, 3356, 3447, 3457, 3495, 3515, 3613, 3621, 3634, 3646, 3661, 3673, 3689, 3748, 3762, 3779, 3827, 3997, 4139, 4206], 'a': [31, 92, 144, 205, 347, 528, 660, 782, 796, 821, 842, 869, 877, 880, 906, 1117, 1187, 1292, 1296, 1308, 1498, 1532, 1736, 1857, 1867, 1908, 1913, 1957, 1961, 2221, 2302, 2329, 2380, 2492, 2559, 2583, 2663, 2819, 2929, 3020, 3036, 3070, 3085, 3231, 3271, 3312, 3327, 3366, 3375, 3435, 3455, 3465, 3471, 3485, 3565, 3571, 3581, 3587, 3648, 3662, 3702, 3752, 3780, 3797, 3830, 3867, 3930, 4066, 4177, 4196], 'wide': [32, 145, 3103], 'range': [33, 146], 'assay': [35, 148, 297], 'platforms,': [36, 149, 2395], 'including': [37, 150, 301, 495, 3311, 3553, 3878, 4045, 4156], 'i)': [38, 151, 580, 1660], 'immunohistochemistry': [39, 152, 2610, 2965, 3709, 3839, 4050], 'detailed': [41, 154, 3944], 'tissue': [42, 99, 155, 212, 511, 516, 658, 1473, 2616, 2649, 2675, 2730, 2750, 2766, 2780, 2794, 2840, 2854, 2870, 2894, 2902, 2955, 2977, 3067, 3146, 3149, 3164, 3188, 3228, 3519, 3910, 4087, 4111], 'profiling,': [43, 156], 'ii)': [44, 157, 583, 1677], 'specific': [45, 61, 158, 174, 367, 413, 1864, 2164, 2305, 3413, 3649], 'affinity': [46, 159, 356, 1050, 1078, 1185, 1211, 1615, 2170, 2309], 'reagents': [47, 57, 160, 170, 291, 357, 1904, 1955, 1977, 2171], 'various': [49, 162, 604, 3047], 'functional': [50, 163, 785, 1982, 2327], 'protein': [51, 96, 164, 209, 307, 530, 554, 568, 589, 593, 602, 617, 652, 674, 685, 776, 908, 970, 1009, 1028, 1111, 1149, 1191, 1253, 1276, 1297, 1317, 1369, 1418, 1444, 1456, 1489, 1769, 1945, 2055, 2112, 2314, 2472, 2505, 3030, 3181, 3206, 3279, 3331, 3362, 3463, 3490, 3542, 3645, 3686, 3836, 3882, 4197], 'assays,': [52, 165, 1985], 'and': [53, 63, 69, 94, 101, 110, 166, 176, 182, 207, 214, 223, 280, 304, 309, 434, 487, 499, 501, 534, 577, 611, 637, 749, 831, 854, 909, 933, 1066, 1126, 1140, 1153, 1247, 1315, 1363, 1486, 1550, 1559, 1639, 1646, 1684, 1774, 1798, 1859, 1891, 1924, 1975, 1983, 2060, 2084, 2150, 2180, 2304, 2340, 2365, 2386, 2396, 2406, 2433, 2448, 2510, 2548, 2555, 2566, 2607, 2637, 2673, 2747, 2799, 2849, 2862, 2899, 2918, 2926, 2966, 3046, 3062, 3112, 3116, 3176, 3223, 3256, 3278, 3387, 3390, 3400, 3460, 3470, 3498, 3521, 3592, 3618, 3636, 3665, 3698, 3720, 3724, 3793, 3835, 3844, 3884, 3892, 3901, 3928, 3947, 3988, 4049, 4104, 4131, 4137, 4166, 4185, 4201, 4212], 'iii)': [54, 167, 587, 1754], 'capture': [55, 168], '("pull-down")': [56, 169], 'purification': [59, 172, 1061, 1081, 1143, 1171, 1212, 1249, 1551, 1616, 1808, 2263, 2310], 'their': [64, 177], 'associated': [65, 178], 'complexes': [66, 179], 'structural': [68, 181, 403, 1300], 'biochemical': [70, 183, 410, 663, 1154], 'analyses.': [71, 184], 'In': [72, 185, 354, 479, 666, 889, 1048, 1508, 2001, 2356, 3019, 3178, 3601, 4003], 'this': [73, 186, 480, 1536, 3179, 3547, 3563, 3578, 3607], 'review,': [74, 187, 481], 'such': [80, 193, 1134, 1197, 1221, 1439, 1670, 1995, 2046, 2136, 2375, 3701], 'will': [82, 195, 483, 518], 'discussed': [84, 197], 'with': [85, 198, 503, 675, 691, 735, 1172, 1327, 1352, 1541, 1573, 1580, 1897, 1997, 2271, 2316, 2338, 2427, 2896, 3381, 3528, 3558, 3841, 4058], 'focus': [86, 199], 'on': [87, 200, 346, 390, 884, 895, 902, 1106, 1132, 2079, 2103, 2313, 2373, 2430, 2826, 2916, 3125, 3251, 3275, 3532, 4113], 'possibility': [89, 202, 2398, 2545, 3798], 'create': [91, 204, 1584], 'descriptive': [93, 206], 'comprehensive': [95, 208, 529, 4121], 'atlas': [97, 210, 531, 4198], 'distribution': [100, 213, 4158], 'subcellular': [102, 215, 2556, 3945], 'localization': [103, 216, 3252, 4009, 4202], 'both': [108, 221, 930, 1855, 3042, 4183], 'normal': [109, 222, 2563, 3043, 3083, 3163, 3496, 3605, 3635], 'disease': [111, 224, 3637, 3656], 'tissues.': [112, 225, 2864], 'A': [226, 960, 2258, 2410, 2532, 2635, 2949, 3198, 3340, 3873, 4025], 'great': [227], 'need': [228, 1137, 2378, 2389], 'exists': [229], 'proteome': [240], '(1.Agaton': [241], 'C.': [242, 772, 973, 996, 1382, 1405, 1695, 1711, 1810, 2230, 3713, 3744], 'Uhlen': [243, 769, 1003, 1412, 1818, 2238], 'M.': [244, 323, 325, 341, 447, 762, 770, 982, 1004, 1091, 1097, 1391, 1413, 1819, 2239, 2687, 2946], 'Hober': [245, 1820, 2240], 'S.': [246, 254, 343, 453, 764, 774, 988, 1000, 1099, 1263, 1397, 1409, 1747, 1821, 2241, 2691], 'Genome-based': [247], 'proteomics.Electrophoresis.': [248], '2004;': [249, 263, 396, 1779, 1794, 1834, 2038, 2065, 2129, 2254, 2754, 2772, 3015, 4227], '25:': [250, 2525], '1280-1288Google': [251], 'Scholar,': [252, 333, 445, 760, 1709, 1782, 2527, 2628, 2757, 3001, 3732, 4230], '2.Hanash': [253], 'HUPO': [255], 'initiatives': [256], 'relevant': [257, 3674], 'clinical': [259, 533, 3073, 3234, 4191], 'proteomics.Mol.': [260], 'Cell.': [261, 1019, 1428, 3972], 'Proteomics.': [262, 1020, 1429], '3:': [264], '298-301Google': [265], 'Scholar).': [266, 353, 478, 648, 791, 959, 1024, 1164, 1268, 1377, 1837, 1951, 2068, 2132, 2216, 2257, 2543, 2713, 2775, 2961, 3018, 3079, 3240, 3506, 3773, 3976, 4100], 'These': [267, 2169], 'efforts,': [268, 3406], 'usually': [269, 595, 687, 848, 1871, 2020], 'denoted': [270], 'antibody': [271, 544, 1372, 1493, 1702, 1790, 2034, 2207, 2306, 2361, 2370, 2402, 2420, 2622, 3353, 3432, 3560, 3579, 3608, 3650], 'proteomics,': [272], 'is': [273, 546, 653, 686, 698, 711, 717, 801, 828, 856, 966, 1202, 1277, 1538, 1557, 1562, 1964, 2005, 2260, 2265, 2342, 2346, 2422, 2783, 2841, 2856, 2871, 2878, 3295, 3354, 3396, 3445, 3492, 3525, 3651, 3678, 3912, 3923, 3978, 4037, 4051, 4128, 4142, 4193], 'here': [274], 'defined': [275, 1914, 1976, 2550], 'as': [276, 468, 522, 524, 689, 781, 818, 1135, 1198, 1222, 1495, 1622, 1671, 1907, 1973, 1996, 2047, 2137, 2148, 2227, 2269, 2336, 2376, 2466, 2486, 2928, 3069, 3230, 3372, 3374, 3751, 3817, 3819, 3864, 3866], 'systematic': [278, 1008, 1417, 3663], 'Affinity': [290, 1005, 1414], 'utilized': [294, 2162, 2589], 'numerous': [296, 3301], 'platforms': [298, 1980], '(Fig.': [299, 2810, 3166, 3575], '1),': [300], 'vivo': [303], 'vitro': [306, 1761, 2073, 2140, 3690], 'profiling': [308, 517, 1010, 1419, 2705, 2993, 3009, 3068, 3229, 3716, 4034, 4221], 'pull-out': [311], 'experiments': [312], 'enable': [314, 4015], 'identification': [315], 'interaction': [317], 'partners': [318], 'or': [319, 400, 406, 586, 1200, 1325, 1675, 1722, 1999, 2042, 2580, 3693, 3917, 4208], 'posttranslational': [320, 1479], 'modifications': [321], '(3.Tyers': [322], 'Mann': [324], 'From': [326, 1151, 2789], 'genomics': [327, 404], 'proteomics.Nature.': [329], '2003;': [330, 350, 956, 1021, 1161, 1430, 3973, 4097], '422:': [331, 351], '193-197Google': [332], '4.Phizicky': [334], 'E.': [335, 768, 986, 1395, 3740, 4232], 'Bastiaens': [336], 'P.I.': [337], 'Zhu': [338], 'H.': [339, 455, 1725, 2612, 3483, 4070, 4080, 4082], 'Snyder': [340], 'Fields': [342], 'Protein': [344, 385, 953, 1446], 'proteomic': [348], 'scale.Nature.': [349], '208-215Google': [352], 'addition,': [355, 890, 1049, 2002, 4004], 'spotted': [360], 'onto': [361, 2801], 'microarrays': [362, 512, 2701, 4088], 'detection': [365, 387, 392, 1984], 'biomolecules': [368], 'complex': [370], 'biosamples': [371], '(5.Espina': [372], 'V.': [373], 'Woodhouse': [374], 'E.C.': [375], 'Wulfkuhle': [376], 'J.': [377, 975, 998, 1176, 1178, 1239, 1384, 1407, 2523, 2681, 2693, 2942, 2957, 2984, 3007, 4219], 'Asmussen': [378], 'H.D.': [379], 'Petricoin': [380], '3rd,': [381], 'E.F.': [382], 'Liotta': [383], 'L.A.': [384, 2940], 'microarray': [386, 2988, 3715], 'strategies:': [388], 'Focus': [389], 'direct': [391], 'technologies.J.': [393], 'Immunol.': [394, 756, 1777, 1792, 2036, 2063, 2127, 2652, 3013, 4225], 'Methods.': [395, 1778, 1793, 2037, 2064, 2128, 2653, 3014, 4226], '290:': [397, 1780, 1795, 2039, 2066, 2130, 3016, 4228], '121-133Google': [398], 'Scholar)': [399, 1433, 1721, 1752], 'efforts': [405], 'studies': [407, 2825, 2885, 3380, 4010], 'function': [411], '(6.Miroux': [415, 618], 'B.': [416, 619, 1093, 1095, 2087, 2195], 'Walker': [417, 620], 'J.E.': [418, 621], 'Over-production': [419, 622], 'Escherichia': [423, 472, 626], 'coli:': [424, 627], 'Mutant': [425, 628], 'hosts': [426, 606, 629], 'that': [427, 570, 630, 702, 860, 868, 1271, 1282, 1435, 1969, 2261, 2324, 2343, 2855, 2881, 3026, 3348, 3408, 3491, 3631, 4129], 'allow': [428, 514, 631, 1320, 3325, 3810, 4152], 'synthesis': [429, 632], 'some': [431, 634, 667, 2413, 2428, 3426], 'membrane': [432, 635], 'globular': [435, 638], 'at': [437, 640, 2552], 'high': [438, 641], 'levels.J.': [439, 642], 'Mol.': [440, 643, 2211, 2752, 2996, 4095], 'Biol.': [441, 644, 2212, 2753], '1996;': [442, 645], '260:': [443, 646], '289-298Google': [444, 647], '7.Hammarstrom': [446], 'Hellgren': [448], 'N.': [449, 3479], 'van': [450], 'Den': [451], 'Berg': [452], 'Berglund': [454], 'Hard': [456], 'T.': [457, 2759], 'Rapid': [458, 1246], 'screening': [459, 1685, 2004, 2345, 3329], 'improved': [461, 3388], 'solubility': [462, 1139], 'small': [464, 896, 2833, 2851], 'produced': [467, 1884], 'fusion': [469, 1103, 1737], 'coli.Protein': [473], 'Sci.': [474, 955, 1261, 1745], '2002;': [475, 2213, 2540], '11:': [476], '313-321Google': [477], 'discuss': [484], 'issues': [486], 'strategic': [488], 'alternatives': [489], 'antibodies,': [494, 1636], 'choice': [496, 1128, 2368, 2418, 3914], 'antigen': [498, 569, 819, 965, 1621, 1629, 2226], 'advantages': [500, 2364, 2432], 'disadvantages': [502, 2434], 'different': [504, 565, 823, 1514, 1993, 2319, 2332, 2571, 2897, 3089, 3153, 3174, 3192, 3246, 3555, 3790, 3897, 4107], 'types': [505, 566, 1653, 2572, 3048, 3165, 3284, 3322, 3569], 'antibodies.': [507, 560, 1523, 1881], 'high-throughput': [515, 543, 2703, 2721, 2991, 3011, 3027, 4090, 4154, 4223], 'also': [519, 1630, 2115, 2159, 3202, 3679, 3849, 3992], 'discussed,': [521], 'well': [523, 3373, 3818, 3865], 'value': [526], 'biomedical': [535], 'research.': [536], 'One': [537, 3148, 4125, 4187], 'main': [540], 'difficulties': [541], 'production': [548, 2188, 2204, 4046], 'sufficiently': [550], 'large': [551, 832, 870, 1118, 1608, 1626, 2827, 4067], 'amounts': [552, 833, 1609, 1627, 2834], 'targets': [555], 'There': [561], 'are': [562, 726, 847, 864, 1123, 1286, 1511, 1526, 1650, 1928, 1990, 2019, 2218, 2325, 3243, 3415, 3513, 3848, 3858, 4123], 'three': [563, 1512, 3152], 'principally': [564, 1513], 'generated,': [573], 'excluding': [574], 'genetic': [575], 'immunization,': [576, 808], 'those': [578], 'are:': [579, 1454], 'full-length': [581, 592, 1038], 'proteins,': [582, 1039], 'synthetic': [584, 816, 826, 949, 1313, 1554], 'peptides,': [585], 'recombinant': [588, 601, 969, 1083, 1256, 1467, 1488, 1574, 1596, 1755], 'fragments.': [590], 'route': [594, 827], 'involves': [596], 'expression': [598, 777, 1549, 2506, 3031, 3182, 3207, 3280, 3332, 3363, 3687, 3837, 4033, 4200], 'eukaryotic': [605], 'mimic': [608], 'folding': [610], 'posttranslation': [612], 'modification': [613], 'native': [616, 651, 676, 724, 861, 1251, 1309, 1858], 'Alternatively,': [649], 'purified': [654, 673], 'from': [655, 671, 1343, 1689, 1788, 1804, 2032, 2124, 2220, 2892, 3093, 3151, 3190, 3300, 3688, 3696, 3700], 'an': [656, 1668, 2274, 2297, 2497, 2718, 2740, 2879, 2971, 3409, 3418, 3431, 3559], 'appropriate': [657], 'by': [659, 1255, 1497, 1665, 1682, 1771, 1885, 2022, 2057, 2191, 2208, 2844, 3010, 4222], 'series': [661], 'unit': [664], 'operations.': [665], 'cases,': [668, 723], 'but': [669, 1561, 1587, 2110, 3991], 'far': [670], 'always,': [672], 'fold': [677], 'obtained,': [680, 1287], 'although': [681, 1288, 1535], 'amount': [683, 1879, 2852, 2868, 3314, 3875], 'low': [688, 1328, 1353, 1543], 'compared': [690, 2270, 2337, 2887], 'other': [693, 1331, 2043, 3529, 3595], 'strategies': [694], 'described': [695], 'below.': [696], 'It': [697, 716, 3677, 3977], 'interesting': [699], 'note': [701], 'advantage': [704, 1604, 1842, 2335, 3775, 4127], 'correctly': [706, 797], 'folded': [707, 798, 862, 886, 1284], 'antigens': [708, 1518, 2101], 'during': [709, 728], 'immunization': [710, 730, 1666, 1683], 'not': [712, 718, 858, 882, 899, 2661, 3140, 3626, 3983], 'yet': [713, 4120], 'thoroughly': [714], 'investigated.': [715], 'unlikely': [719, 1281], 'that,': [720], 'many': [722, 920, 2318, 2464, 2484], 'denaturated': [727, 803, 1991, 2475], 'procedure,': [731], 'i.e.': [732, 3130, 4172], 'mixing': [734], 'mineral': [736], 'oil': [737], 'preparation': [740], "Freund's": [742], 'adjuvance': [743], '(8.Lise': [744], 'L.D.': [745], 'Audibert': [746], 'F.': [747, 1002, 1365, 1411, 3064, 3225], 'Immunoadjuvants': [748], 'analogs': [750], 'immunomodulatory': [752], 'bacterial': [753], 'structures.Curr.': [754], 'Opin.': [755], '1989;': [757], '2:': [758, 1022, 1431], '269-274Google': [759], '9.Larsson': [761], 'Graslund': [763], 'Yuan': [765], 'L.': [766, 980, 1101, 1389, 1817, 2146, 2197, 2237, 2683], 'Brundell': [767, 985, 1394], 'Hoog': [771, 995, 1404], 'Stahl': [773, 999, 1408], 'High-throughput': [775], 'cDNA': [779], 'products': [780, 1015, 1424], 'tool': [783, 2499, 2665, 3071, 3232, 3367], 'genomics.J.': [786], 'Biotechnol.': [787, 1160, 2153], '2000;': [788, 1718, 1948, 2106, 2154, 3770], '80:': [789], '143-157Google': [790], 'importance': [793, 3336], 'generating': [795, 1307, 1606], 'protein,': [799, 1962, 3564], 'which': [800, 1058, 1224, 1612, 1846, 1901, 1918, 2010, 2348, 2724, 3647, 3856, 4014], 'subsequently': [802], 'immediately': [804], 'prior': [805], 'could': [809, 1302, 3032], 'therefore': [810, 857, 2371, 2969], 'questioned.': [812], 'peptides': [817, 846, 897, 950, 1324], 'represents': [820], 'completely': [822], 'strategy.': [824], 'technically': [829, 2266], 'simple': [830], 'pure': [835, 1072], 'peptide': [836, 878, 924, 1314, 1555], 'readily': [838, 3859], 'made': [840, 1481, 1664, 1681, 1758, 2185], 'short': [843, 1042], 'time.': [844], 'less': [849, 1873, 1905, 2013], 'than': [850, 1036, 1086, 1874, 2285], '40': [851], 'amino': [852], 'acids': [853], 'it': [855, 1280, 1482, 1963, 3023], 'likely': [859, 1529], 'structures': [863, 1285], 'obtained.': [865], 'This': [866, 3523], 'means': [867], 'fraction': [871], 'obtained': [874, 3429], 'recognize': [876, 1956], 'form': [881], 'present': [883, 2558], 'target': [887, 2167], 'protein.': [888], 'linear': [892, 1569], 'epitopes': [893, 1370, 2294, 2320], 'exposed': [894, 901], 'might': [898], 'surface': [904], 'thus': [910, 3185, 3658, 3979], 'lead': [911], 'nonfunctional': [913], 'subsequent': [917, 1632, 4059], 'assays.': [918, 2333], 'However,': [919, 1862, 1952, 2280, 3936], 'examples': [921], 'successful': [923], 'have': [926, 1531, 1602, 1839, 1912, 2114, 2158, 2183, 2460, 2480, 2600, 2886, 3263, 3543, 3887, 4116], 'been': [927, 2077, 2116, 2160, 2184, 2461, 2481, 2588, 2601, 3544, 3888, 4118], 'generated': [928, 1803, 2174, 2219, 3433, 3561], 'academic': [932], 'commercial': [935, 1157, 4102], 'sector': [936], '(10.Meloen': [937], 'R.H.': [938], 'Puijk': [939], 'W.C.': [940], 'Langeveld': [941], 'J.P.': [942, 944], 'Langedijk': [943], 'Timmerman': [945], 'P.': [946, 1727, 2634, 2689, 3738, 4076], 'Design': [947], 'diagnostics.Curr.': [952], 'Pept.': [954], '4:': [957, 2711], '253-260Google': [958], 'third': [961], 'way': [962], 'produce': [964, 1487, 1517, 1740], 'generate': [968, 1967, 2008, 3682, 4195], 'fragments': [971, 1029, 1044, 1326, 1490, 1575, 2315], '(11.Agaton': [972, 1381], 'Galli': [974, 1383], 'Hoiden': [976, 1385, 1813, 2233], 'Guthenberg': [977, 1386, 1814, 2234], 'I.': [978, 990, 1180, 1387, 1399, 1815, 2235], 'Janzon': [979, 1388], 'Hansson': [981, 1390], 'Asplund': [983, 1392], 'A.': [984, 1243, 1264, 1393, 1748, 1767, 1833, 2053, 2121, 2199, 2253, 2529, 2685, 3003, 3054, 3215, 3711, 4215], 'Lindberg': [987, 1096, 1396], 'Ruthberg': [989, 1398], 'Wester': [991, 1400], 'K.': [992, 1145, 1401, 3734], 'Wurtz': [993, 1402], 'D.': [994, 1403, 1765, 2051], 'Lundeberg': [997, 1406], 'Ponten': [1001, 1410], 'chromosome': [1012, 1421, 1506], '21': [1013, 1422], 'gene': [1014, 1108, 1423, 3524], 'tissues.Mol.': [1018, 1427], '405-414Google': [1023, 1432], 'makes': [1030, 1059, 1279, 1847, 1902, 1919], 'cloning': [1032], 'procedures': [1033, 2593], 'much': [1034], 'easier': [1035], 'because': [1040, 1209, 1953, 4011], 'relatively': [1041, 1542, 1588, 1607], 'PCR': [1043], 'used.': [1047, 4024], 'tags': [1051, 1079], 'purification,': [1057], 'procedure': [1062, 2264], 'easy': [1063, 3925, 4180], 'scale-up': [1065, 2352, 3399], 'reliable': [1067], 'antigen.': [1073], 'Since': [1074], 'introduction': [1076], 'more': [1085, 2267, 2284, 3378, 3812], '20': [1087], 'years': [1088], 'ago': [1089], '(12.Uhlen': [1090], 'Nilsson': [1092], 'Guss': [1094], 'Gatenbeck': [1098], 'Philipson': [1100], 'Gene': [1102], 'vectors': [1104], 'based': [1105, 2078, 3124, 3250, 3274], 'staphylococcal': [1110], 'A.Gene.': [1112], '1983;': [1113], '23:': [1114], '369-378Google': [1115], 'Scholar),': [1116, 1196, 2041, 2109, 2157, 2657], 'number': [1119, 2898, 3411], 'tag': [1121, 1148, 1167], 'systems': [1122], 'now': [1124, 2716], 'available': [1125, 3860, 3891], 'system': [1130, 1168], 'depends': [1131, 2372], 'factors': [1133], 'ease': [1141, 1577, 2383, 4039], '(13.Terpe': [1144], 'Overview': [1146], 'fusions:': [1150], 'molecular': [1152, 2704, 2992, 3260, 4093], 'fundamentals': [1155], 'systems.Appl.': [1158], 'Microbiol.': [1159], '60:': [1162], '523-533Google': [1163], 'histidine': [1166], 'immobilized': [1173], 'metals': [1174], '(14.Porath': [1175], 'Carlsson': [1177], 'Olsson': [1179], 'Belfrage': [1181], 'G.': [1182, 1237, 1693, 2697, 2986], 'Metal': [1183], 'chelate': [1184], 'chromatography,': [1186], 'new': [1188, 2493, 2533, 2950, 3386], 'approach': [1189, 3200, 3395], 'fractionation.Nature.': [1192], '1975;': [1193, 1706], '258:': [1194], '598-599Google': [1195], 'Co': [1199], 'Ni,': [1201], 'most': [1204, 1528, 1931, 3320, 4209], 'frequently': [1205], 'system,': [1207], 'partly': [1208, 3123], 'performed': [1215, 3034], 'buffers': [1217], 'containing': [1218, 3041, 3509, 3604], 'chaotrophic': [1219], 'reagents,': [1220], 'urea,': [1223], 'allows': [1225, 1613, 2815, 3929], 'precipitated': [1226], '(inclusion': [1228], 'bodies)': [1229], 'recovered': [1232], '(15.Janknecht': [1233], 'R.': [1234, 1812, 2232, 4078], 'de': [1235], 'Martynoff': [1236], 'Lou': [1238], 'Hipskind': [1240], 'R.A.': [1241], 'Nordheim': [1242], 'andStunnenberg': [1244], 'H.G.': [1245], 'efficient': [1248, 2638], 'histidine-tagged': [1252], 'expressed': [1254, 1278, 3493, 3996], 'vaccinia': [1257], 'virus.Proc.': [1258], 'Natl.': [1259, 1743], 'Acad.': [1260, 1744], 'U.': [1262, 1746, 2982], '1991;': [1265], '88:': [1266], '8972-8976Google': [1267], 'fact': [1270], 'only': [1272, 2832, 2842, 2866, 3593, 3984], 'part': [1273], 'fully': [1283], 'careful': [1289], 'selection': [1290, 1322, 1437, 1762, 2044, 2074, 2385, 3121], 'fragment': [1293, 1318], 'domain': [1298, 3469], 'integrity': [1301], 'increase': [1303], 'probability': [1305, 2299], 'configuration.': [1310], 'Both': [1311], 'routes': [1319, 1887], 'homology': [1329], 'proteome,': [1336], 'enabling': [1337], 'information': [1342], 'genome': [1346], 'sequence': [1347], 'design': [1349, 1485, 2917, 2934], 'epitope-specific': [1350], 'risk': [1354], 'cross-reactivity': [1356, 1890], '(16.Lindskog,': [1357], 'M.,': [1358, 1362, 3061, 3222], 'Rockberg,': [1359], 'J.,': [1360], 'Uhlen,': [1361, 3060, 3221], 'Sterky,': [1364], '(2005)': [1366, 3065, 3226], 'Selection': [1367], 'production.': [1373], 'BioTechniques,': [1374], 'press.Google': [1376, 3078, 3239], 'Agaton': [1378], 'et': [1379], 'al.': [1380], 'showed': [1434, 3570, 3609], 'unique': [1440, 2861, 3346], 'regions': [1441], 'called': [1445], 'Epitope': [1447], 'Signatures': [1448], 'Tags': [1449], '(PrESTs)': [1450], '1The': [1451], 'abbreviations': [1452], 'PrEST,': [1455], 'epitope': [1457, 1959, 2450], 'signatures': [1458], 'tags;': [1459], 'pAb,': [1460], 'polyclonal': [1461, 1661, 1826, 2222, 2246], 'antibody;': [1462, 1465, 1468], 'mAb,': [1463], 'monoclonal': [1464, 1678, 1733, 1954, 2206, 2645], 'recAb,': [1466], 'msAb,': [1469], 'mono-specific': [1470, 1800], 'antibodies;': [1471], 'TMA,': [1472, 2875], 'microarrays;': [1474], 'IgG,': [1475], 'immunoglobulin': [1476], 'G;': [1477], 'PTM,': [1478], 'modification.': [1480], 'possible': [1483, 3397, 3680, 3980], 'suitable': [1491, 1849, 2014], 'generation,': [1494], 'exemplified': [1496], 'pilot': [1499], 'study': [1500, 2519, 3685, 3852], 'using': [1501, 1619, 1806, 2224, 2831, 3035, 3838, 3956, 4029, 4168], 'genes': [1503], '21.': [1507], 'conclusion,': [1509, 2357], 'there': [1510, 1649, 3857], 'ways': [1515], 'Full-length': [1524], 'correct': [1533], 'fold,': [1534], 'strategy': [1537, 1556, 1572, 2973], 'often': [1539, 1589, 1888, 1989, 2321], 'cumbersome': [1540, 4130], 'success': [1544], 'rates': [1545], 'combined': [1548, 3840], 'steps.': [1552], 'rapid': [1558, 2636, 4157], 'convenient,': [1560], 'generally': [1563, 2784], 'limited': [1564, 2867], 'epitopes.': [1570], 'combines': [1576], 'potential': [1582, 2431, 3335, 3466], 'conformational': [1585], 'epitopes,': [1586], 'yields': [1590], 'insoluble': [1591], 'inclusion': [1592], 'bodies': [1593], 'host.': [1597], 'two': [1599, 2911], 'latter': [1600], 'approaches': [1601], 'antigen,': [1611, 1900], 'ligand.': [1623], 'Availability': [1624], 'facilitates': [1631, 2349], 'quality': [1633], 'assurance': [1634], 'e.g.': [1637, 3134, 3597], 'adsorption': [1638], 'binding': [1640, 1916, 2134], 'assays': [1641, 1852], 'test': [1643], 'specificity': [1645], 'selectivity.': [1647], 'Currently,': [1648], 'four': [1651, 2913], 'major': [1652, 3114, 4026, 4126], 'analysis:': [1659], '(pAb)': [1663], 'animal,': [1669], 'rabbit,': [1672], 'hen,': [1673], 'goat,': [1674], 'rat;': [1676], '(mAb)': [1680], 'B': [1687], 'cells': [1688, 1700, 2511, 3620, 3692], 'antibody-producing': [1690], 'mouse': [1691], '(17.Kohler': [1692], 'Milstein': [1694], 'Continuous': [1696], 'cultures': [1697], 'fused': [1699], 'secreting': [1701], 'predefined': [1704], 'specificity.Nature.': [1705], '256:': [1707], '495-497Google': [1708], '18.Milstein': [1710], 'With': [1712], 'benefit': [1714, 4027], 'hindsight.Immunol.': [1716], 'Today.': [1717, 1947], '21:': [1719, 1949], '359-364Google': [1720], 'rabbit': [1723], '(19.Spieker-Polet': [1724], 'Sethupathi': [1726], 'Yam': [1728], 'P.C.': [1729], 'Knight': [1730], 'K.L.': [1731], 'Rabbit': [1732], 'antibodies:': [1734], 'Generating': [1735], 'partner': [1738], 'rabbit-rabbit': [1741], 'hybridomas.Proc.': [1742], '1995;': [1749], '92:': [1750], '9348-9352Google': [1751], 'cells;': [1753], '(recAb)': [1757], 'through': [1759, 4144], 'principles': [1763], '(20.Lipovsek': [1764, 2050], 'Pluckthun': [1766, 2052], 'In-vitro': [1768, 2054], 'evolution': [1770, 2056], 'ribosome': [1772, 2058], 'display': [1773, 2025, 2049, 2059, 2193], 'mRNA': [1775, 2061], 'display.J.': [1776, 2062, 2210], '51-67Google': [1781, 2067], '21.Bradbury': [1783], 'A.R.': [1784, 2028], 'Marks': [1785, 2029, 2088, 2200], 'J.D.': [1786, 2030, 2089, 2201], 'Antibodies': [1787, 1940, 2031], 'phage': [1789, 2024, 2033, 2091, 2192, 2209], 'libraries.J.': [1791, 2035], '29-49Google': [1796, 2040], 'Scholar);': [1797], 'iv)': [1799], '(msAb)': [1802], 'pAbs': [1805, 1838, 2312, 2479], 'antigen-specific': [1807], '(22.Agaton': [1809, 2229], 'Falk': [1811, 2231], 'Gostring': [1816, 2236], 'Selective': [1822, 2242], 'enrichment': [1823, 2243], 'monospecific': [1825, 2245], 'efforts.J.': [1831, 2251], 'Chromatogr.': [1832, 2252], '1043:': [1835, 2255], '33-40Google': [1836, 2256], 'inherent': [1841], 'multi-epitope': [1844], 'binding,': [1845], 'them': [1848, 1920, 2012], 'cross-platform': [1851], 'denatured': [1860], 'form.': [1861], 'pAb': [1868, 1883], 'reagent': [1869], '(antiserum)': [1870], 'constitute': [1872], '1%': [1875], 'total': [1878], 'Thus,': [1882], 'standard': [1886, 2931], 'show': [1889], 'lack': [1892, 3144], 'reproducibility': [1894], 'upon': [1895], 're-immunizations': [1896], 'same': [1899, 3541], 'these': [1903], 'attractive': [1906, 1921, 2972], 'renewable': [1909, 2381], 'resource.': [1910], 'mAbs': [1911, 1927, 2339], 'single': [1915, 1958, 1974, 2096, 2584, 2820, 3472, 3781], 'epitope,': [1917], 'diagnostic': [1923, 1936, 2151, 2536, 3389], 'therapeutic': [1925, 2149, 3391], 'applications.': [1926, 2355], 'currently': [1929], 'commonly': [1932], 'immunoreagents': [1934], 'applications': [1937], '(23.Borrebaeck': [1938], 'C.A.': [1939], 'diagnostics—From': [1942], 'immunoassays': [1943, 3666], 'chips.Immunol.': [1946], '379-382Google': [1950], 'difficult': [1965], 'across': [1978, 2328, 2392], 'whole': [1979, 2893], 'where': [1986], 'ways,': [1994], 'detergents': [1998], 'formalin.': [2000], 'time-consuming': [2003, 4132], 'needed': [2006, 2857], 'mAbs,': [2009, 2446], 'render': [2011], 'large-scale': [2016], 'efforts.': [2017], 'recAbs': [2018, 2190, 2341], 'selected': [2021, 2141, 3092, 3099, 3161], 'utilizing': [2023], 'technologies': [2026, 4108], '(21.Bradbury': [2027], 'principles,': [2045], 'ribosomal': [2048], 'Much': [2069], 'technology': [2075, 2677, 2715, 2814, 2951, 2968, 2989, 4031], 'has': [2076, 2362, 2587], 'recAb': [2080], 'fragments,': [2081], 'especially': [2082], 'scFvs': [2083], 'Fabs': [2085], '(24.Liu': [2086], 'Applying': [2090], 'proteomics:': [2094], 'Selecting': [2095], 'chain': [2097], 'Fv': [2098], 'blotted': [2102], 'nitrocellulose.Anal.': [2104], 'Biochem.': [2105], '286:': [2107], '119-128Google': [2108], 'alternative': [2111, 2125], 'scaffolds': [2113], '(25.Nygren': [2118], 'P.A.': [2119], 'Skerra': [2120], 'Binding': [2122], 'scaffolds.J.': [2126], '3-28Google': [2131], 'Nonproteinaceous': [2133], 'ligands,': [2135], 'aptamers': [2142], '(26.Brody': [2143], 'E.N.': [2144], 'Gold': [2145], 'Aptamers': [2147], 'agents.J.': [2152], '74:': [2155], '5-13Google': [2156], 'successfully': [2161], 'recognition': [2165], 'molecules.': [2168], 'without': [2175, 3786], 'animals': [2179], 'recently': [2181, 3264, 4117], 'attempts': [2182, 2350], 'toward': [2186, 3562], 'proteome-wide': [2187, 2203], '(27.Liu': [2194], 'Huang': [2196], 'Burlingame': [2198], 'Towards': [2202], '1:': [2214], '1063-1073Google': [2215], 'msAbs': [2217], 'antiserum': [2223, 2275], 'ligand': [2228], 'disadvantage': [2259], 'challenging': [2268], 'consisting': [2276], 'nonpurified': [2278], 'pAbs.': [2279], 'elimination': [2282], '99%': [2286], 'directed': [2290], 'other,': [2292], 'unknown': [2293], 'results': [2295, 2922], 'increased': [2298], 'obtaining': [2301], 'selective': [2303], 'reagent.': [2307, 2836], 'potentially': [2317], 'renders': [2322], 'highly': [2326, 3131], 'platform': [2330], 'An': [2334, 3904], 'no': [2344], 'needed,': [2347], 'whole-proteome': [2354, 3405], 'each': [2358, 2436, 2790, 3158, 3195, 3305, 3352], 'type': [2359], 'its': [2363, 2845], 'disadvantages.': [2366], 'factors,': [2374], 'resource,': [2382], 'screening,': [2387], 'several': [2393, 2595, 2598, 2805, 4016], 'routine': [2404], 'diagnostics': [2405, 3268], 'therapy': [2407], 'patients.': [2409], 'summary': [2411], 'considerations': [2415], 'related': [2416], 'class': [2421, 2437], 'shown': [2423, 3025, 3355, 3446], 'Table': [2425], 'I': [2426], 'comments': [2429], 'antibodies.Table': [2439], 'IComparison': [2440], 'pAbs,': [2445], 'recAbs,': [2447], 'msAbsParameterpAbmAbrecAbmsAbUniform': [2449], 'specificity–+++Renewable': [2451], 'resource+/−+++/−Need': [2452], 'animalsYesYesNoYesSuitability': [2455], 'diagnostics+++++++Suitability': [2457], 'therapeutics–apAbs': [2459], 'decades': [2465, 2485], 'vaccines': [2467, 2487], '(gammaglobulin).++/−–Suitability': [2468], '"pull-down"++/−+/−+Suitability': [2470], 'arrays+++++++Detection': [2473], 'proteins+++/−+/−++Need': [2476], 'screeningNoYesYesNoa': [2478], '(gammaglobulin).': [2488], 'Open': [2489], 'table': [2490], 'tab': [2494], 'Immunohistochemistry': [2495], 'provides': [2496, 2717, 3365], 'important': [2498, 4188], 'situ': [2502], 'visualization': [2503], 'patterns': [2507, 3183, 3208, 3333, 3633, 4203], 'tissues': [2509, 2830, 3045, 3090, 3117, 3497, 3638, 4036, 4044, 4211], '(28.Spicer': [2512], 'S.S.': [2513], 'Advantages': [2514], 'histochemistry': [2516], 'cell': [2521, 3694, 3721, 3791, 3825, 3861, 3871, 3894, 3952], 'biology.Histochem.': [2522], '1993;': [2524], '531-547Google': [2526], '29.Gown': [2528], 'Genogenic': [2530], 'immunohistochemistry:': [2531], 'era': [2534], 'immunohistochemistry.Curr.': [2537], 'Diagn.': [2538, 4096], 'Pathol.': [2539, 3769], '8:': [2541], '193-200Google': [2542], 'detect': [2547], 'localize': [2549], 'tissue,': [2553], 'cellular,': [2554], 'levels': [2557], 'deeper': [2560], 'insight': [2561], 'into': [2562, 2735, 3245], 'cellular': [2564], 'functions': [2565], 'pathogenic': [2567], 'mechanisms': [2568], 'leading': [2569], 'disease.': [2574], 'multiple': [2578, 2648, 4012], 'biopsies': [2579], 'curettages': [2581], 'paraffin': [2585, 2737], 'block': [2586, 2738, 3704], 'surgical': [2591, 3128], 'pathology': [2592], 'decades.': [2596], 'Although': [2597], 'articles': [2599], 'published': [2602, 3889], 'describing': [2603], 'improvements': [2604], 'methodology': [2606], 'usefulness': [2608], '(30.Battifora': [2611], 'multitumor': [2614], '(sausage)': [2615], 'block:': [2617], 'Novel': [2618], 'method': [2619, 2639, 3922], 'immunohistochemical': [2621, 2642], 'testing.Lab.': [2623], 'Invest.': [2624, 3726], '1986;': [2625], '55:': [2626], '244-248Google': [2627], '31.Wan': [2629], 'W.H.': [2630], 'Fortuna': [2631], 'M.B.': [2632], 'Furmanski': [2633], 'testing': [2641], 'reactivity': [2643], 'against': [2647], 'samples': [2650, 2731, 3172, 3299, 3695, 3863], 'simultaneously.J.': [2651], '1987;': [2654], '103:': [2655], '121-129Google': [2656], 'multi-tissue': [2658], 'blocks': [2659, 2895], 'did': [2660], 'become': [2662], 'powerful': [2664], 'research': [2667, 3371], 'until': [2668], 'designated': [2669], 'instruments': [2670], 'were': [2671, 3098, 3118, 3139, 3184, 3349], 'developed': [2672], 'array': [2676, 2741], 'was': [2678, 3024, 3091, 3122, 3155, 3201], 'standardized': [2679, 3037], '(32.Kononen': [2680], 'Bubendorf': [2682], 'Kallioniemi': [2684, 2698], 'Barlund': [2686], 'Schraml': [2688], 'Leighton': [2690], 'Torhorst': [2692], 'Mihatsch': [2694], 'M.J.': [2695], 'Sauter': [2696, 2985], 'O.P.': [2699, 2980], 'Tissue': [2700, 2947, 2987, 3714], 'tumor': [2707, 3255, 3458], 'specimens.Nat.': [2708], 'Med.': [2709], '1998;': [2710], '844-847Google': [2712], 'TMA': [2714, 2791, 2813, 2906, 2921, 2933, 2967, 3293, 3603, 4030], 'automated': [2719, 3801, 4064], 'array-based': [2720], 'technique,': [2722], 'up': [2725], '1,000': [2727], 'paraffin-embedded': [2729], 'assembled': [2734, 3156], 'one': [2736], 'format': [2742, 3294], '(33.Hewitt': [2743], 'S.M.': [2744, 2763], 'Design,': [2745], 'construction,': [2746], 'microarrays.Methods': [2751], '264:': [2755], '61-72Google': [2756], '34.Braunschweig': [2758], 'Chung': [2760], 'J.Y.': [2761], 'Hewitt': [2762], 'Perspectives': [2764], 'microarrays.Comb.': [2767], 'Chem.': [2768], 'High': [2769], 'Throughput': [2770], 'Screen.': [2771], '7:': [2773, 2959], '575-585Google': [2774], 'diameter': [2777], 'sample': [2781], 'cores': [2782, 2903], '0.6–1.5': [2785], 'mm': [2786], 'diameter.': [2788], 'block,': [2792], 'thin': [2793], 'sections': [2795, 2891, 3699, 4112], 'cut': [2798], 'mounted': [2800], 'glass': [2802, 4114, 4135], 'slides,': [2803], 'producing': [2804], 'hundred': [2806], 'nearly': [2807], 'identical': [2808], 'slides': [2809, 4115, 4136], '2).': [2811], 'investigators': [2816], 'slide': [2821, 4056], 'conduct': [2823], 'controlled': [2824], 'cohorts': [2828], 'source': [2838], 'restricted': [2843], 'availability': [2846, 3126], 'paraffin,': [2848], 'minimizes': [2858], 'loss': [2859], 'sparse': [2863], 'As': [2865, 3417], 'individual': [2876, 3302, 3316, 3556], 'heterogeneity': [2877], 'issue': [2880, 3905], 'needs': [2882], 'consideration.': [2883], 'Several': [2884], 'size': [2900], 'format.': [2907], 'cores,': [2914], 'depending': [2915], 'content': [2919], '>95%': [2924], 'accuracy': [2925], 'appears': [2927], 'reasonable': [2930, 3313], '(35.Rimm': [2935], 'D.L.': [2936], 'Camp': [2937], 'R.L.': [2938], 'Charette': [2939], 'Costa': [2941], 'Olsen': [2943], 'D.A.': [2944], 'Reiss': [2945], 'microarray:': [2948], 'amplification': [2953], 'resources.Cancer': [2956], '2001;': [2958, 2998, 3503, 3727], '24-31Google': [2960], 'combination': [2963], 'presents': [2970], 'high-throughput,': [2975], '(36.Kallioniemi': [2979], 'Wagner': [2981], 'Kononen': [2983], 'cancer.Hum.': [2995], 'Genet.': [2997], '10:': [2999], '657-662Google': [3000], '37.Warford': [3002], 'Howat': [3004, 4216], 'W.': [3005, 4072, 4074, 4217], 'McCafferty': [3006, 4218], 'Expression': [3008, 4220], 'immunohistochemistry.J.': [3012, 4224], '81-92Google': [3017, 4229], 'recent': [3021], 'study,': [3022], 'set': [3038, 3086], 'TMAs': [3040, 3310, 3552, 3828, 4048], 'cancer': [3050, 3211, 3247, 3286, 3307, 3324, 3338, 3370, 3424, 3551, 3568, 3718], '(38.Kampf,': [3051, 3212], 'C.,': [3052, 3055, 3213, 3216], 'Andersson,': [3053, 3214], 'Wester,': [3056, 3217], 'K.,': [3057, 3218], 'Bjorling,': [3058, 3219], 'E.,': [3059, 3220], 'Ponten,': [3063, 3224], 'Antibody-based': [3066, 3227], 'proteomics.': [3074, 3235], 'Clin.': [3075, 3236], 'Proteomics,': [3076, 3237], 'For': [3080], 'representation': [3081], 'tissues,': [3084, 3133, 3606, 3617], '48': [3088, 3162], 'body.': [3096], 'Tissues': [3097], 'comprise': [3101], 'variety': [3104], 'phenotypes': [3106], 'found': [3107], 'within': [3108, 3304], 'body,': [3111], 'all': [3113, 4207], 'organs': [3115, 4213], 'included.': [3119], 'material,': [3129], 'specialized': [3132], 'eye,': [3135], 'ear,': [3136], 'spinal': [3137], 'chord': [3138], 'included': [3141], 'due': [3142], 'resources.': [3147], 'core': [3150], 'individuals': [3154, 3193], '3).': [3167], 'When': [3168, 3549], 'applicable,': [3169], 'triplicate': [3171], 'represented': [3173], 'sex': [3175], 'age.': [3177], 'manner,': [3180], 'analyzed': [3186, 3350, 4020], 'spots': [3189], '144': [3191], 'tested': [3196], 'antibody.': [3197], 'similar': [3199], 'analyze': [3205], 'Malignant': [3241], 'tumors': [3242, 3303, 3317, 3347, 3557], 'classified': [3244], 'types,': [3248], 'mainly': [3249], 'primary': [3254, 3328], 'phenotypical': [3257], 'characteristics.': [3258], 'New': [3259], 'biological': [3261, 3970], 'tools': [3262], 'altered': [3265], 'classical': [3267], 'resulting': [3269], 'modified': [3272], 'classification,': [3273], 'mutation': [3276], 'patterns,': [3281], 'certain': [3283], '(most': [3287], 'evident': [3288], 'hematological': [3290, 3853], 'malignancies).': [3291], 'ideal': [3296], 'assembling': [3298], 'separate': [3306], 'type.': [3308], 'Cancer': [3309], 'representing': [3318, 3896], 'common': [3321], 'development.': [3339], 'schematic': [3341], 'overview': [3342], 'showing': [3343], '216': [3345, 3554], 'Fig.': [3357, 3448], '4.': [3358], 'Screening': [3359], 'tumor-associated': [3361], 'profiles': [3364, 3911], 'basic': [3369], 'foundation': [3376], 'in-depth': [3379], 'aim': [3383], 'finding': [3385], 'agents.': [3392], 'presented': [3394], 'provided': [3407], 'adequate': [3410], 'available.': [3416, 3652], 'example': [3419, 3629], 'TMAs,': [3425], 'representative': [3427], 'images': [3428, 4151, 4162], 'member': [3436], 'ALEX': [3439, 3451], 'family': [3440, 3530], '(ALEX3': [3443], 'protein)': [3444], '5.': [3449], 'may': [3453], 'play': [3454], 'role': [3456], 'suppression,': [3459], 'encoded': [3462], 'contains': [3464], 'N-terminal': [3467], 'transmembrane': [3468], 'Armadillo': [3473], '(arm)': [3474], 'repeat': [3475, 3489, 3512], '(39.Kurochkin': [3476], 'I.V.': [3477], 'Yonemitsu': [3478], 'Funahashi': [3480], 'S.I.': [3481], 'Nomura': [3482], 'ALEX1,': [3484], 'novel': [3486], 'armadillo': [3488], 'differentially': [3494], 'carcinomas.Biochem.': [3499], 'Biophys.': [3500], 'Res.': [3501], 'Commun.': [3502], '280:': [3504], '340-347Google': [3505], 'Other': [3507], 'arm': [3511], 'involved': [3514], 'development,': [3516], 'maintenance': [3517], 'integrity,': [3520], 'carcinogenesis.': [3522], 'localized': [3526], 'together': [3527], 'members': [3531], 'X': [3534], 'chromosome.': [3535], 'Three': [3536], 'transcript': [3537], 'variants': [3538], 'encoding': [3539], 'identified': [3545, 3660], 'gene.': [3548], 'staining': [3550, 3574, 3612, 3632], 'subset': [3566, 3588], 'strong': [3572], 'positive': [3573, 3611], '5).': [3576], 'Interestingly,': [3577], 'stained': [3580, 4086], 'majority': [3582], 'hepatocellular': [3585], 'carcinomas,': [3586], 'ovarian': [3590], 'carcinomas': [3591], 'rare': [3594, 3619], 'tumors,': [3596], '1/12': [3598], 'malignant': [3599], 'melanomas.': [3600], 'exclusive': [3610], 'liver,': [3614], 'testes,': [3615], 'brain': [3616], 'GI': [3623], 'tract': [3624], '(data': [3625], 'shown).': [3627], 'shows': [3630], 'rapidly': [3641], 'screened': [3642], 'every': [3644], 'Potential': [3653], 'biomarkers': [3654], 'manner': [3664], 'designed': [3669], 'further': [3671], 'validation': [3672], 'patient': [3675], 'cohorts.': [3676], 'arrays': [3683], 'cultured': [3691], 'patients': [3697], 'cell-TMA': [3703], '(40.Hoos': [3710], 'Cordon-Cardo': [3712], 'specimens': [3719], 'lines:': [3722], 'Opportunities': [3723], 'limitations.Lab.': [3725], '81:': [3728], '1331-1338Scopus': [3729], '(210)': [3730], 'Google': [3731], '41.Wester': [3733], 'Andersson': [3735], 'A.C.': [3736], 'Ranefall': [3737], 'Bengtsson': [3739], 'Malmstrom': [3741], 'P.U.': [3742], 'Busch': [3743], 'Cultured': [3745], 'fibroblasts': [3747], 'agarose': [3749], 'gel': [3750], 'multi-functional': [3753], 'control': [3754], 'immunohistochemistry.': [3756, 3919], 'Standardization': [3757], 'Ki67': [3759], '(MIB1)': [3760], 'assessment': [3761], 'routinely': [3763], 'processed': [3764], 'urinary': [3765], 'bladder': [3766], 'carcinoma': [3767], 'tissue.J.': [3768], '190:': [3771], '503-511Google': [3772], 'analyzing': [3777], 'immunoreactivity': [3778], 'layer': [3782], 'dispersed': [3784], 'cells,': [3785], 'complexity': [3788], 'populations': [3792], 'matrix': [3794], 'background,': [3795], 'includes': [3796], 'employ': [3800], 'image': [3802, 3806, 3842, 4060, 4184], 'systems.': [3804], 'Standardized': [3805], 'algorithms': [3808], 'would': [3809], 'objective': [3813, 4189], 'measures': [3814], 'qualitative': [3816], 'quantitative': [3820], 'parameters.': [3821], 'Furthermore,': [3822], 'utilization': [3823], 'lines': [3826], 'facilitate': [3829, 4007], 'comparative': [3831, 4008], 'transcription': [3834, 3880], 'cDNA-array': [3845], 'technologies.': [3846], 'Cell-TMAs': [3847], 'advantageous': [3850], 'malignancies,': [3854], 'aspirate': [3862], 'multitude': [3868], 'established': [3870], 'lines.': [3872], 'considerable': [3874], 'data': [3877], 'genotype,': [3879], 'profiles,': [3881], 'expression,': [3883], 'phenotypic': [3885], 'characteristics': [3886], 'well-characterized': [3893], 'lines,': [3895], 'stages': [3898], 'lymphoid': [3900], 'myeloid': [3902], 'differentiation.': [3903], 'between': [3915, 3985], 'fluorescence-': [3916], 'enzyme-based': [3918, 3921], 'sensitive,': [3924], 'automate,': [3927], 'rudimentary': [3931], 'intracellular': [3934], 'localization.': [3935], 'fluorescent-based': [3938], 'methods': [3939, 4006], 'three-dimensional': [3948], 'reconstruction': [3949], 'done': [3955], 'confocal': [3957, 3965], 'microscopy': [3958, 4174], '(42.Amos': [3959], 'W.B.': [3960], 'White': [3961], 'J.G.': [3962], 'How': [3963], 'laser': [3966], 'scanning': [3967, 4057, 4110], 'microscope': [3968, 4141], 'entered': [3969], 'research.Biol.': [3971], '95:': [3974], '335-342Google': [3975], 'discriminate': [3982], 'nuclear,': [3986], 'cytoplasmic,': [3987], 'membrane-bound': [3989], 'localization,': [3990], 'determine': [3994], 'mitochondria,': [3998], 'nucleoli,': [3999], 'nuclear': [4000], 'membrane,': [4001], 'etc.': [4002], 'fluorescent': [4005], 'dyes,': [4013], 'simultaneously,': [4021], 'automation.': [4041], 'Collection': [4042], 'fairly': [4052], 'labor': [4053], 'intensive,': [4054], 'whereas': [4055], 'processing': [4061], 'degree': [4068], '(43.Vrolijk': [4069], 'Sloos': [4071], 'Mesker': [4073], 'Franken': [4075], 'Fodde': [4077], 'Morreau': [4079], 'Tanke': [4081], 'Automated': [4083], 'acquisition': [4084], 'evaluation': [4091, 4138], 'targets.J.': [4094], '5:': [4098], '160-167Google': [4099], 'Various': [4101], 'software': [4103], 'hardware': [4105], 'employing': [4106], 'developed,': [4119], 'publications': [4122], 'sparse.': [4124], 'handling': [4133], 'avoided': [4143], 'digital': [4148], 'data.': [4149, 4186], 'Digital': [4150, 4161], 'over': [4159], 'networks.': [4160], 'viewed': [4165], 'scored': [4167], 'conventional': [4169], 'web-based': [4170], 'tools,': [4171], 'virtual': [4173], 'coupled': [4175], 'database,': [4178], 'facilitating': [4179], 'access': [4181], 'displaying': [4199], '(37.Warford': [4214], '44.Marengo': [4231], 'Robott': [4233]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2106845528', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 21}, {'year': 2012, 'cited_by_count': 23}], 'updated_date': '2024-12-09T08:41:58.227262', 'created_date': '2016-06-24'}