Title: Re-functionalisation of α-substituted isocolchicides via nucleophilic tele-substitution
Abstract: 9-Methoxyisocolchicide 1 in excess methanethiolate–methanol, or Me2SO, slowly undergoes ipso-substitution giving 9-methylthioisocolchicide 3, which then suffers tele-substitution giving 11-methylthioisocolchicide 2; this activation by dicoordinated sulfur is used for amino re-functionalisation of the isocolchicide system.
Publication Year: 1994
Publication Date: 1994-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 6
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