We Need Both Randomized Trials and Real-World Data: The Example of Everolimus as Second-Line Therapy for mRCC

Name: Work Video:
Duration: 3 min 30 s
Mimma Rizzo; Giacomo Cartenì; Giovanni Pappagallo
{'id': 'https://openalex.org/W2106797350', 'doi': 'https://doi.org/10.2217/fon.14.182', 'title': 'We Need Both Randomized Trials and Real-World Data: The Example of Everolimus as Second-Line Therapy for mRCC', 'display_name': 'We Need Both Randomized Trials and Real-World Data: The Example of Everolimus as Second-Line Therapy for mRCC', 'publication_year': 2014, 'publication_date': '2014-08-21', 'ids': {'openalex': 'https://openalex.org/W2106797350', 'doi': 'https://doi.org/10.2217/fon.14.182', 'mag': '2106797350', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25142886'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2217/fon.14.182', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S174572715', 'display_name': 'Future Oncology', 'issn_l': '1479-6694', 'issn': ['1479-6694', '1744-8301'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'editorial', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5044527837', 'display_name': 'Mimma Rizzo', 'orcid': 'https://orcid.org/0000-0001-7743-741X'}, 'institutions': [{'id': 'https://openalex.org/I4210087768', 'display_name': 'Ospedale Antonio Cardarelli', 'ror': 'https://ror.org/003hhqx84', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087768']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mimma Rizzo', 'raw_affiliation_strings': ["UOC di Oncologia, Azienda Ospedaliera 'A. Cardarelli', Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "UOC di Oncologia, Azienda Ospedaliera 'A. Cardarelli', Naples, Italy", 'institution_ids': ['https://openalex.org/I4210087768']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031898133', 'display_name': 'Giacomo Cartenì', 'orcid': 'https://orcid.org/0000-0003-1441-6376'}, 'institutions': [{'id': 'https://openalex.org/I4210087768', 'display_name': 'Ospedale Antonio Cardarelli', 'ror': 'https://ror.org/003hhqx84', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087768']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giacomo Cartenì', 'raw_affiliation_strings': ["UOC di Oncologia, Azienda Ospedaliera 'A. Cardarelli', Naples, Italy"], 'affiliations': [{'raw_affiliation_string': "UOC di Oncologia, Azienda Ospedaliera 'A. Cardarelli', Naples, Italy", 'institution_ids': ['https://openalex.org/I4210087768']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080212287', 'display_name': 'Giovanni Pappagallo', 'orcid': 'https://orcid.org/0000-0002-8247-9224'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanni Pappagallo', 'raw_affiliation_strings': ['Ufficio di Epidemiologia &amp; Sperimentazioni Cliniche, Dipartimento di Scienze Mediche, U.O.C. di Oncologia &amp; Ematologia Oncologica; Azienda Sanitaria ULSS 13, via L. Mariutto, 76-30035Mirano, Venice, Italy'], 'affiliations': [{'raw_affiliation_string': 'Ufficio di Epidemiologia &amp; Sperimentazioni Cliniche, Dipartimento di Scienze Mediche, U.O.C. di Oncologia &amp; Ematologia Oncologica; Azienda Sanitaria ULSS 13, via L. Mariutto, 76-30035Mirano, Venice, Italy', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.942857, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '10', 'issue': '12', 'first_page': '1893', 'last_page': '1896'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11235', 'display_name': 'Statistical Methods in Clinical Trials', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2613', 'display_name': 'Statistics and Probability'}, 'field': {'id': 'https://openalex.org/fields/26', 'display_name': 'Mathematics'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11235', 'display_name': 'Statistical Methods in Clinical Trials', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2613', 'display_name': 'Statistics and Probability'}, 'field': {'id': 'https://openalex.org/fields/26', 'display_name': 'Mathematics'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10449', 'display_name': 'Renal cell carcinoma treatment', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9777, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7779056}, {'id': 'https://openalex.org/C2779473830', 'wikidata': 'https://www.wikidata.org/wiki/Q1540899', 'display_name': 'MEDLINE', 'level': 2, 'score': 0.6512875}, {'id': 'https://openalex.org/C23131810', 'wikidata': 'https://www.wikidata.org/wiki/Q818574', 'display_name': 'Observational study', 'level': 2, 'score': 0.63150066}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.61252785}, {'id': 'https://openalex.org/C512399662', 'wikidata': 'https://www.wikidata.org/wiki/Q3505712', 'display_name': 'Family medicine', 'level': 1, 'score': 0.3293856}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29099977}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019317', 'descriptor_name': 'Evidence-Based Medicine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D064887', 'descriptor_name': 'Observational Studies as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016032', 'descriptor_name': 'Randomized Controlled Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015331', 'descriptor_name': 'Cohort Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068338', 'descriptor_name': 'Everolimus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020123', 'descriptor_name': 'Sirolimus', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2217/fon.14.182', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S174572715', 'display_name': 'Future Oncology', 'issn_l': '1479-6694', 'issn': ['1479-6694', '1744-8301'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25142886', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.61, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W127038563', 'https://openalex.org/W1490826681', 'https://openalex.org/W1978138475', 'https://openalex.org/W2002225701', 'https://openalex.org/W2007532627', 'https://openalex.org/W2013350088', 'https://openalex.org/W2018408437', 'https://openalex.org/W2030936866', 'https://openalex.org/W2055171585', 'https://openalex.org/W2066361244', 'https://openalex.org/W2098894094', 'https://openalex.org/W2122132792', 'https://openalex.org/W2138129102', 'https://openalex.org/W2140531948', 'https://openalex.org/W2589184112', 'https://openalex.org/W2952011418'], 'related_works': ['https://openalex.org/W4396763100', 'https://openalex.org/W4312214387', 'https://openalex.org/W4210484722', 'https://openalex.org/W2616141209', 'https://openalex.org/W2550575390', 'https://openalex.org/W2318707379', 'https://openalex.org/W2108965305', 'https://openalex.org/W2091031254', 'https://openalex.org/W1967947002', 'https://openalex.org/W1871178219'], 'abstract_inverted_index': {'Future': [0, 477, 563, 620, 696, 740, 783, 817, 835, 947, 1022, 1041, 1086, 1115], 'OncologyVol.': [1], '10,': [2, 1093], 'No.': [3, 507, 550, 567, 592, 624, 700, 744, 787, 821, 839, 860, 887, 897, 951, 965, 988, 1026, 1045, 1090, 1094], '12': [4, 1095], 'EditorialWe': [5], 'need': [6], 'both': [7], 'randomized': [8, 129, 176, 577], 'trials': [9, 131, 579], 'and': [10, 149, 177, 219, 272, 331, 387, 491, 628, 714, 911], 'real-world': [11], 'data:': [12], 'the': [13, 111, 156, 217, 273, 294, 556, 641, 891, 971, 1034, 1055, 1147, 1154, 1177], 'example': [14], 'of': [15, 194, 213, 221, 238, 267, 275, 296, 322, 333, 383, 441, 445, 483, 494, 509, 527, 535, 705, 712, 850, 863, 893, 974, 1033, 1054, 1058, 1179, 1190], 'everolimus': [16, 323, 969], 'as': [17, 466], 'second-line': [18, 467, 972], 'therapy': [19, 353, 468], 'for': [20, 52, 248, 324, 354, 427, 469, 524, 1176], 'mRCCMimma': [21], 'Rizzo,': [22], 'Giacomo': [23, 38], 'Cartenì': [24, 39], '&': [25, 49, 60, 70, 161, 614, 690, 734, 776, 811, 829, 941, 1016, 1080, 1121], 'Giovanni': [26, 50, 608, 610, 651], 'PappagalloMimma': [27], 'Rizzo': [28, 457], 'UOC': [29, 40], 'di': [30, 41, 58, 64, 68], 'Oncologia,': [31, 42], 'Azienda': [32, 43, 73], 'Ospedaliera': [33, 44], "'A.": [34, 45], "Cardarelli',": [35, 46], 'Naples,': [36, 47], 'Italy,': [37], 'Italy': [48], 'Pappagallo*Author': [51], 'correspondence:': [53], 'E-mail': [54], 'Address:': [55], '[email protected]': [56], 'Ufficio': [57], 'Epidemiologia': [59], 'Sperimentazioni': [61], 'Cliniche,': [62], 'Dipartimento': [63], 'Scienze': [65], 'Mediche,': [66], 'U.O.C.': [67], 'Oncologia': [69], 'Ematologia': [71], 'Oncologica;': [72], 'Sanitaria': [74], 'ULSS': [75], '13,': [76, 743, 786, 820, 838], 'via': [77], 'L.': [78, 107], 'Mariutto,': [79], '76-30035': [80], 'Mirano,': [81], 'Venice,': [82], 'ItalyPublished': [83], 'Online:11': [84], 'Nov': [85], '2014https://doi.org/10.2217/fon.14.182AboutSectionsView': [86], 'ArticleView': [87], 'Full': [88], 'TextSupplemental': [89], 'MaterialPDF/EPUB': [90], 'ToolsAdd': [91], 'to': [92, 132, 154, 436, 890, 990], 'favoritesDownload': [93], 'CitationsTrack': [94], 'CitationsPermissionsReprints': [95], 'ShareShare': [96], 'onFacebookTwitterLinkedInRedditEmail': [97], 'View': [98], 'articleKeywords:': [99], 'everolimusmRCCobservational': [100], 'studiesrandomized': [101, 1118], 'trialssecond-line': [102, 1119], 'therapyReferences1': [103], 'Revicki': [104], 'DA,': [105], 'Frank': [106], 'Pharmacoeconomic': [108], 'evaluation': [109], 'in': [110, 175, 242, 389, 552, 572, 581, 595, 632, 640, 716, 754, 789, 841, 874, 900, 954, 970, 984, 992, 1028, 1047, 1110, 1142, 1153], 'real': [112], 'world.': [113], 'Effectiveness': [114], 'versus': [115], 'efficacy': [116, 388, 715], 'studies.': [117, 134, 179, 448], 'Pharmacoeconomics': [118], '15(5),': [119], '423–434': [120], '(1999).Crossref,': [121], 'Medline,': [122, 141, 187, 205, 231, 284, 307, 340, 365, 414], 'CAS,': [123, 206, 232, 285, 308, 341, 415], 'Google': [124, 142, 188, 207, 233, 261, 286, 309, 342, 366, 416], 'Scholar2': [125], 'Silverman': [126], 'SL.': [127], 'From': [128], 'controlled': [130], 'observational': [133, 178, 239], 'Am.': [135], 'J.': [136, 200, 210, 226, 279, 289, 409, 449], 'Med.': [137, 201, 227, 280, 303], '122(2),': [138], '114–120': [139], '(2009).Crossref,': [140], 'Scholar3': [143], 'Riegelman': [144], 'R.': [145], 'Studying': [146], 'a': [147, 151, 442, 474, 707, 755, 795, 864, 871, 909, 912, 958, 993, 1000, 1052, 1059, 1139], 'Study': [148, 377], 'Testing': [150], 'Test:': [152], 'How': [153], 'Read': [155], 'Medical': [157], 'Evidence.': [158], 'Lippincott': [159], 'Williams': [160], 'Wilkins,': [162], 'PA,': [163], 'USA': [164], '(2000).Google': [165], 'Scholar4': [166], 'Landewé': [167], 'R,': [168], 'van': [169], 'der': [170], 'Heijde': [171], 'D.': [172, 351], 'Primer:': [173], 'challenges': [174], 'Nat.': [180], 'Clin.': [181, 450], 'Pract.': [182], 'Rheumatol.': [183], '3(11),': [184], '661–666': [185], '(2007).Crossref,': [186, 230, 260], 'Scholar5': [189], 'Ray': [190], 'WA.': [191], 'Population-based': [192], 'studies': [193, 266], 'adverse': [195, 297], 'drug': [196, 222, 268, 298], 'effects.': [197], 'N.': [198, 224, 277, 300], 'Engl.': [199, 225, 278, 301], '349(17),': [202], '1592–1594': [203], '(2003).Crossref,': [204], 'Scholar6': [208], 'Avorn': [209, 288], 'In': [211], 'defense': [212], 'pharmaco-epidemiolology': [214], '–': [215, 270, 292], 'embracing': [216], 'yin': [218], 'yang': [220], 'research.': [223, 243], '357(22),': [228], '2219–2221': [229], 'Scholar7': [234], 'Lubeck': [235], 'DP.': [236], 'Use': [237], 'databases': [240], '(registries)': [241], 'In:': [244], 'Clinical': [245, 536, 851], 'Research': [246], 'Methods': [247], 'Surgeons.': [249], 'Penson': [250], 'DF,': [251], 'Wei': [252], 'JT': [253], '(Eds).': [254], 'Humana': [255], 'Press,': [256], 'NY,': [257], 'USA,': [258], '95–104': [259], 'Scholar8': [262], 'Hiatt': [263], 'WR.': [264], 'Observational': [265], 'safety': [269, 386, 1061], 'aprotinin': [271], 'absence': [274], 'transparency.': [276], '355(21),': [281, 304], '2171–2173': [282], '(2006).Crossref,': [283, 306], 'Scholar9': [287], 'Dangerous': [290], 'deception': [291], 'hiding': [293], 'evidence': [295], 'events.': [299], 'J': [302], '2169–2171': [305], 'Scholar10': [310], 'Motzer': [311], 'RJ,': [312], 'Escudier': [313], 'B,': [314], 'Oudard': [315], 'S': [316], 'et': [317, 374, 424, 463], 'al.': [318, 375, 425, 464], 'Phase': [319], '3': [320], 'trial': [321], 'metastatic': [325, 392, 430, 470, 635, 717, 1050], 'renal': [326, 393, 431, 471, 636, 976], 'cell': [327, 394, 432, 472, 637, 977], 'carcinoma:': [328, 473, 555], 'final': [329], 'results': [330, 440], 'analysis': [332, 444], 'prognostic': [334, 626], 'factors.': [335], 'Cancer': [336, 410], '116(8),': [337], '4256–4265': [338], '(2010).Crossref,': [339], 'Scholar11': [343], 'Zustovich': [344], 'F,': [345], 'Lombardi': [346], 'G,': [347, 460], 'Nicoletto': [348], 'O,': [349], 'Pastorelli': [350], 'Second-line': [352], 'refractory': [355, 435, 792], 'renal-cell': [356], 'carcinoma.': [357], 'Crit.': [358], 'Rev.': [359], 'Oncol.': [360, 451, 478], 'Hematol.': [361], '83(1),': [362], '112–122': [363], '(2012).Crossref,': [364, 413], 'Scholar12': [367], 'Grünwald': [368], 'V,': [369], 'Karakiewicz': [370], 'PI,': [371], 'Bavbek': [372], 'SE': [373], 'REACT': [376], 'Group.': [378], 'An': [379], 'international': [380], 'expanded-access': [381], 'programme': [382], 'everolimus:': [384], 'addressing': [385], 'patients': [390, 428, 633, 902], 'with': [391, 429, 529, 634, 751, 757, 870, 903, 968, 1133, 1138, 1146], 'carcinoma': [395, 433, 638], 'who': [396], 'progress': [397], 'after': [398], 'initial': [399], 'vascular': [400], 'endothelial': [401], 'growth': [402], 'factor': [403], 'receptor-tyrosine': [404], 'kinase': [405], 'inhibitor': [406], 'therapy.': [407], 'Eur.': [408], '48(3),': [411], '324–332': [412], 'Scholar13': [417], 'Albiges': [418], 'L,': [419, 421], 'Bergmann': [420], 'Eymard': [422], 'JC': [423], 'Everolimus': [426, 465], '(mRCC)': [434], 'anti-VEGF': [437], 'therapy:': [438], 'Preliminary': [439], 'pooled': [443], 'non': [446], 'interventional': [447], '31(6),': [452], 'Abstract': [453], '392': [454], '(2013).Google': [455], 'Scholar14': [456], 'M,': [458], 'Facchini': [459], 'Savastano': [461], 'C': [462], "'real-life'": [475], 'study.': [476], 'doi:10.2217/FON.14.170': [479], '(2014)': [480], '(Epub': [481], 'ahead': [482], 'print).Google': [484], 'Scholar15': [485], 'ABPI.': [486], 'abpi.org.uk/our-work/library/guidelines/Documents/2011–06–13Google': [487], 'ScholarFiguresReferencesRelatedDetailsCited': [488], 'ByGenomic': [489], 'Profiling': [490], 'Molecular': [492], 'Characterization': [493], 'Clear': [495], 'Cell': [496, 498, 532], 'Renal': [497, 531], 'Carcinoma20': [499], 'October': [500, 853, 1112], '2023': [501, 544], '|': [502, 545, 562, 587, 619, 695, 739, 782, 816, 834, 855, 946, 981, 1021, 1040, 1085], 'Current': [503], 'Oncology,': [504, 547, 564, 621, 697, 741, 784, 818, 836, 894, 948, 1023, 1042, 1087], 'Vol.': [505, 548, 565, 590, 622, 698, 742, 785, 819, 837, 858, 885, 895, 949, 963, 986, 1024, 1043, 1088, 1092], '30,': [506], '10Comparison': [508], 'Outcomes': [510], 'Between': [511], 'Therapeutic': [512, 982], 'Combinations': [513], 'Based': [514], 'on': [515, 710, 1188], 'Immune': [516], 'Checkpoint': [517], 'Inhibitors': [518], 'or': [519, 1130, 1136, 1143, 1150, 1163, 1168, 1171, 1173], 'Tyrosine': [520], 'Kinase': [521], 'Inhibitor': [522], 'Monotherapy': [523], 'First-Line': [525], 'Therapy': [526], 'Patients': [528, 843], 'Advanced': [530], 'Carcinoma': [533], 'Outside': [534], 'Trials:': [537], 'A': [538], 'Real-World': [539], 'Retrospective': [540], 'Multi-Institutional': [541], 'Study21': [542], 'March': [543, 585], 'Targeted': [546], '18,': [549], '2Lenvatinib': [551], 'differentiated': [553], 'thyroid': [554], 'Italian': [557, 598, 642, 1035, 1056], 'experienceAlessandro': [558], 'Piovesan6': [559], 'August': [560, 617, 1019, 1038], '2019': [561, 586], '15,': [566], '24sMRI': [568], 'ultrasound': [569], 'fusion': [570], 'biopsy': [571], 'prostate': [573], 'cancer': [574, 719, 998], 'detection:': [575], 'Are': [576], 'clinical': [578, 583, 630], 'reproducible': [580], 'everyday': [582], 'practice?19': [584], 'Urologia': [588], 'Journal,': [589, 884], '86,': [591], '1Dabrafenib–trametinib': [593], 'combination': [594], "'field-practice':": [596], 'an': [597, 747, 1031], 'experienceRoberta': [599], 'Depenni,': [600], 'Francesco': [601, 658, 777, 942], 'De': [602, 682], 'Rosa,': [603], 'Stefano': [604, 612], 'Greco,': [605], 'Laura': [606], 'Ridolfi,': [607], 'Pellacani,': [609], 'Ponti,': [611], 'Cascinu': [613], 'Massimo': [615], 'Guidoboni7': [616], '2018': [618, 694], '14,': [623, 699], '20Negative': [625], 'factors': [627], 'resulting': [629], 'outcome': [631], 'included': [639], 'nivolumab-expanded': [643], 'access': [644], 'programSergio': [645], 'Bracarda,': [646], 'Luca': [647, 1185], 'Galli,': [648], 'Marco': [649, 663, 805, 920], 'Maruzzo,': [650], 'Lo': [652], 'Re,': [653], 'Sebastiano': [654], 'Buti,': [655], 'Adolfo': [656], 'Favaretto,': [657], 'Di': [659, 778, 827, 930, 1007, 1076], 'Costanzo,': [660], 'Cosimo': [661], 'Sacco,': [662], 'Merlano,': [664], 'Claudia': [665], 'Mucciarini,': [666], 'Elena': [667], 'Zafarana,': [668], 'Sante': [669], 'Romito,': [670], 'Antonio': [671, 1066], 'Maestri,': [672], 'Carmelo': [673], 'G': [674], 'Giorgio,': [675], 'Maria': [676, 773, 807, 928, 932, 1013], 'T': [677], 'Ionta,': [678], 'Daniele': [679], 'Turci,': [680], 'Ugo': [681], 'Giorgi,': [683], 'Giuseppe': [684], 'Procopio,': [685], 'Enrico': [686], 'Cortesi,': [687], 'Diana': [688], 'Giannarelli': [689], 'Camillo': [691], 'Porta18': [692], 'May': [693, 737, 1083], '14Eribulin': [701], 'across': [702], 'multiple': [703, 759, 793], 'lines': [704], 'chemotherapy:': [706], 'retrospective': [708, 913], 'study': [709], 'quality': [711], 'life': [713], 'breast': [718, 907, 997], 'patientsErica': [720], 'Quaquarini,': [721], 'Federico': [722], 'Sottotetti,': [723], 'Daniela': [724], "D'Ambrosio,": [725], 'Alberto': [726], 'Malovini,': [727], 'Stefania': [728], 'Morganti,': [729], 'Arianna': [730], 'Marinello,': [731], 'Lorenzo': [732], 'Pavesi': [733], 'Mara': [735], 'Frascaroli8': [736], '2017': [738, 781, 815, 833], '11sPomalidomide': [745], 'experience:': [746], 'effective': [748], 'therapeutic': [749], 'approach': [750], 'immunomodulatory': [752], 'drugs': [753], 'patient': [756], 'relapsed-refractory': [758], 'myelomaConcetta': [760], 'Conticello,': [761], 'Marina': [762], 'Parisi,': [763], 'Alessandra': [764, 937], 'Romano,': [765], 'Valeria': [766], 'Calafiore,': [767], 'Flavia': [768], 'Ancora,': [769], 'Alessia': [770], 'La': [771], 'Fauci,': [772], 'Letizia': [774], 'Consoli': [775], 'Raimondo24': [779], 'January': [780, 814, 832], '5sPomalidomide': [788], 'heavily': [790, 995], 'pretreated': [791, 996], 'myeloma:': [794], 'case': [796, 1001], 'reportAngelo': [797], 'Palmas,': [798], 'Giovanna': [799], 'Piras,': [800], 'Antonella': [801, 1006], 'Uras,': [802], 'Rosanna': [803, 918, 924], 'Asproni,': [804], 'Murineddu,': [806], 'Monne,': [808], 'Roberta': [809], 'Stradoni': [810], 'Giancarlo': [812], 'Latte24': [813], '5sPomalidomide:': [822], 'when': [823], 'expectations': [824], 'are': [825], 'understatedFrancesco': [826], 'Raimondo': [828], 'Concetta': [830], 'Conticello24': [831], '5sEribulin': [840], 'Male': [842], 'With': [844], 'Breast': [845], 'Cancer:': [846], 'The': [847, 856, 880], 'First': [848], 'Report': [849], 'Outcomes14': [852], '2016': [854], 'Oncologist,': [857], '21,': [859], '11One-year': [861], 'outcomes': [862], 'BioMime™': [865], 'Sirolimus-Eluting': [866], 'Coronary': [867], 'Stent': [868], 'System': [869], 'biodegradable': [872], 'polymer': [873], 'all-comers': [875], 'coronary': [876], 'artery': [877], 'disease': [878], 'patients:': [879], 'meriT-3': [881], 'studyIndian': [882], 'Heart': [883], '68,': [886], '5More': [888], 'colors': [889], 'paletteAnnals': [892], '27,': [896], '23-month': [898], 'triptorelin': [899], 'premenopausal': [901], 'hormone': [904], 'receptor-positive': [905], 'early': [906], 'cancer:': [908], 'commentary': [910], 'experienceMichele': [914], 'Caruso,': [915], 'Gaetano': [916], 'Castiglione,': [917], 'Aiello,': [919], 'Alí,': [921], 'Maurizio': [922], 'Chiarenza,': [923], 'Dimarco,': [925], 'Giuseppa': [926], 'Fallica,': [927], 'Grazia': [929, 1014], 'Leo,': [931, 1003], 'Vita': [933], 'Sanó,': [934], 'Eleonora': [935, 939], 'Taibi,': [936], 'Zacchia,': [938], 'Miano': [940], 'Caruso6': [943], 'November': [944, 1107], '2015': [945, 980, 1020, 1039, 1084], '11,': [950, 1025, 1044, 1089], '23Everolimus': [952], 'treatment': [953, 973], 'advanced': [955, 975], 'solid': [956], 'tumors:': [957], 'personal': [959], 'viewFuture': [960], 'Science': [961], 'OA,': [962], '1,': [964], '3Clinical': [966], 'experience': [967], 'carcinoma30': [978], 'June': [979], 'Advances': [983], 'Urology,': [985], '7,': [987], '5Response': [989], 'eribulin': [991], 'difficult-to-treat,': [994], 'patient:': [999], 'reportLuigi': [1002], 'Francesca': [1004, 1011], 'Caputo,': [1005], 'Sarno,': [1008], 'Tiziana': [1009], 'Garofano,': [1010], 'Andreozzi,': [1012], 'Massaro': [1015], 'Vincenzo': [1017], 'Montesarchio3': [1018], '15sEribulin': [1027], "'field": [1029], "practice':": [1030], 'overview': [1032], 'experienceSandro': [1036], 'Barni3': [1037], '15sVemurafenib': [1046], 'BRAFV600': [1048], 'mutated': [1049], 'melanoma:': [1051], 'subanalysis': [1053], 'population': [1057], 'global': [1060], 'studyMichele': [1062], 'Del': [1063], 'Vecchio,': [1064], 'Paolo': [1065], 'Ascierto,': [1067], 'Mario': [1068], 'Mandalà,': [1069], 'Vanna': [1070], 'Chiarion': [1071], 'Sileni,': [1072], 'Michele': [1073], 'Maio,': [1074], 'Lorenza': [1075], 'Guardo,': [1077], 'Ester': [1078], 'Simeone': [1079], 'Paola': [1081], 'Queirolo8': [1082], '9': [1091], 'STAY': [1096], 'CONNECTED': [1097], 'Supplemental': [1098], 'MaterialsMetrics': [1099], 'Downloaded': [1100], '140': [1101], 'times': [1102], 'History': [1103], 'Published': [1104, 1109], 'online': [1105], '11': [1106], '2014': [1108, 1113], 'print': [1111], 'Information©': [1114], 'Medicine': [1116], 'LtdKeywordseverolimusmRCCobservational': [1117], 'therapyFinancial': [1120], 'competing': [1122], 'interests': [1123], 'disclosureThe': [1124], 'authors': [1125], 'have': [1126], 'no': [1127], 'relevant': [1128], 'affiliations': [1129], 'financial': [1131, 1140, 1144], 'involvement': [1132], 'any': [1134], 'organization': [1135], 'entity': [1137], 'interest': [1141], 'conflict': [1145], 'subject': [1148], 'matter': [1149], 'materials': [1151], 'discussed': [1152], 'manuscript.': [1155], 'This': [1156], 'includes': [1157], 'employment,': [1158], 'consultancies,': [1159], 'honoraria,': [1160], 'stock': [1161], 'ownership': [1162], 'options,': [1164], 'expert': [1165], 'testimony,': [1166], 'grants': [1167], 'patents': [1169], 'received': [1170], 'pending,': [1172], 'royalties.Editorial': [1174], 'assistance': [1175, 1195], 'preparation': [1178], 'this': [1180, 1194], 'manuscript': [1181], 'was': [1182, 1196], 'provided': [1183], 'by': [1184, 1198], 'Giacomelli,': [1186], 'PhD,': [1187], 'behalf': [1189], 'Content': [1191], 'Ed': [1192], 'Net;': [1193], 'funded': [1197], 'Novartis.PDF': [1199], 'download': [1200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2106797350', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-13T03:58:00.634568', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
