N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression

Name: Work Video:
Duration: 3 min 30 s
Thomas Kislinger; Caifeng Fu; Birgit Huber; Wu Qu; Akihiko Taguchi; Shi Du Yan; M. Hofmann; Shi Fang Yan; Monika Pischetsrieder; David M. Stern; Ann Marie Schmidt
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469, 487, 513, 544, 572, 641, 669, 721, 760, 797, 832, 863, 890, 915, 944, 974, 1003, 1029, 1099, 1125, 1237, 1332, 1351, 1376, 1393, 1421, 1443, 1471, 1515, 1541, 1574, 1600, 1634, 1680, 1715, 1759, 1822, 1888, 1908, 1920, 1990, 2016, 2032, 2055, 2105, 2288, 2428, 2446, 2568, 2606, 3653, 3926, 3956, 3995, 4267, 4294], 'Scholar,': [386, 470, 488, 514, 545, 642, 722, 761, 798, 833, 864, 891, 916, 945, 975, 1004, 1100, 1333, 1352, 1377, 1422, 1516, 1542, 1575, 1601, 1909, 1991, 2017, 2033, 2056, 3927], '2Neeper': [387, 3928], 'Schmidt': [389, 617, 653, 766, 803, 904, 959, 992, 1019, 1088, 1115, 1227, 1964, 2000, 2091, 2552, 3930], 'Yan': [393, 704, 731, 776, 848, 871, 898, 1011, 1107, 1219, 1968, 2020, 3934, 4252, 4277], 'S.D.': [394, 616, 705, 777, 800, 849, 872, 899, 1969, 2021, 3935, 4253, 4278], 'Elliston': [399, 3940], 'K.': [400, 532, 553, 559, 561, 738, 1354, 1430, 1502, 1534, 1556, 1581, 1587, 1589, 1591, 1603, 1607, 1624, 1751, 1876, 2266, 2436, 3941], 'Shaw': [403, 1978, 3944], 'A.': [404, 474, 500, 547, 753, 790, 825, 918, 1979, 1981, 1997, 2066, 3945], '14998-15004Abstract': [410, 3951], 'Scholar).': [416, 573, 1030, 1126, 1238, 1394, 1472, 1635, 1760, 1823, 1921, 2106, 2289, 2447, 2607, 3996, 4268], 'heterogeneous': [420, 586], 'class': [421], 'compounds,': [423], 'whose': [424], 'accumulation': [425, 1475], 'diabetes,': [430, 2920], 'failure,': [432, 1841, 2922], "Alzheimer's": [433], 'disease,': [434, 1854], 'and,': [435], 'indeed,': [436, 1946], 'natural': [437], 'aging,': [438], 'albeit': [439], 'lesser': [442], 'degree,': [443], 'has': [444], 'their': [446, 1172, 1267, 1287], 'potential': [447, 2121, 3775], 'contribution': [448], 'pathogenesis': [451, 689], 'these': [456, 1637, 1924, 1953, 2110, 2164, 2878], 'conditions': [457], '(3Brownlee': [458], 'Annu.': [460], 'Rev.': [461], 'Med.': [462, 480, 1022, 1118, 1230, 2025], '1995;': [463, 507, 857, 1345, 1538, 2013, 2026, 2557, 4261], '46:': [464], '223-234Crossref': [465], 'Scopus': [467, 485, 511, 542, 570, 667, 719, 758, 795, 830, 861, 888, 913, 942, 972, 1001, 1027, 1097, 1123, 1235, 1330, 1349, 1374, 1391, 1419, 1441, 1469, 1513, 1572, 1598, 1632, 1713, 1757, 1820, 1886, 1918, 2030, 2053, 2103, 2286, 2426, 2444, 2566, 2604, 3993, 4265, 4292], '(1174)': [468], '4Brownlee': [471], 'Cerami': [473, 499], 'Vlassara': [475, 497], 'N.': [477, 524, 526, 530, 742, 1524, 1546, 1562, 1868, 1870, 1874, 1890, 2072], 'Engl.': [478], '1988;': [481], '318:': [482], '1315-1320Crossref': [483], '(2405)': [486], '5Palinski': [489], 'Koschinsky': [491], 'T.': [492, 516, 534, 549, 551, 814, 893, 920, 924, 1356, 1364, 1522, 1530, 1532, 1550, 1552, 1560, 1577, 1605, 1860, 1878, 2035, 2080, 2268, 2276, 2533], 'Butler': [493], 'S.': [494, 528, 557, 752, 789, 824, 1335, 1366, 1368, 1453, 1518, 1528, 1548, 1558, 1579, 1609, 1611, 1872, 1892, 2039, 2060, 2278, 2280, 2545], 'Miller': [495], 'E.': [496, 868, 870, 1381, 1409, 1749, 1894, 1971, 2594, 3979], 'Witztum': [501, 1621], 'Atheroscler.': [503], 'Thromb.': [504], 'Vasc.': [505], '15:': [508], '571-582Crossref': [509], '(138)': [512], '6Miyata': [515], 'Oda': [517, 1861], 'O.': [518, 650, 775, 837, 874, 895, 981, 989, 1077, 1085, 1747, 1862, 1900, 2074, 2529, 4241], 'Inagi': [519, 1582, 1863], 'R.': [520, 709, 736, 847, 876, 932, 987, 1083, 1554, 1583, 1864, 1999, 2003, 2535, 3981, 3985, 4251, 4282], 'Iida': [521, 902, 1865], 'Y.': [522, 903, 1360, 1866, 2068, 2272], 'Araki': [523, 1363, 1523, 1867, 2275], 'Yamada': [525, 1869], 'Horiuchi': [527, 1367, 1527, 1557, 1871, 2279], 'Taniguchi': [529, 1561, 1873], 'Maeda': [531, 560, 1606, 1875], 'Kinoshita': [533, 1877], 'Clin.': [536, 713, 855, 907, 995, 1091, 1385, 1413, 1626, 1814, 1880, 2598, 3987, 4259, 4286], 'Invest.': [537, 714, 856, 908, 996, 1092, 1386, 1414, 1627, 1815, 1881, 2599, 3988, 4260, 4287], '1993;': [538, 715, 1327, 1882, 1914, 1987, 2441, 4288], '92:': [539, 1883], '1243-1252Crossref': [540, 1884], '(413)': [543, 1887], '7Takedo': [546], 'Yasuda': [548], 'Miyata': [550, 1604, 1608], 'Mizuno': [552], 'Li': [554, 840, 4244], 'Yoneyama': [556], 'Horie': [558, 1586], 'Sobue': [562], 'G.': [563, 620, 740, 808], 'Neurosci.': [564], 'Lett.': [565, 1593], '1996;': [566, 884, 909, 997, 1093, 1370, 1704, 2282], '221:': [567], '17-20Crossref': [568], '(63)': [571], 'Our': [574, 1031], 'previous': [575, 1926], 'demonstrated': [577, 1134, 1401], 'both': [579, 1155, 1736, 2399], 'vitro': [581, 2141], 'vivo': [584, 1315, 2144], 'derived': [585], 'ligate': [588], 'on': [592, 1272, 2766, 3102, 3861, 4146, 4374], 'endothelium': [593], '(ECs),': [594], 'phagocytes': [596], '(MPs),': [597], '(VSMC),': [601], 'neurons': [603], 'activate': [605, 2146], 'ERK1/ERK2': [611], 'kinases': [612], '(8Yan': [615], 'Anderson': [619, 768], 'Zhang': [621, 729, 844, 896, 2536, 4248], 'Zou': [625, 1966], 'Y.S.': [626, 1967], 'Pinsky': [627, 1972], '1994;': [634, 754, 791, 826], '269:': [635], '9889-9897Abstract': [636], '9Lander': [643], 'H.L.': [644], 'Tauras': [645], 'J.M.': [646], 'Ogiste': [647], 'J.S.': [648], 'Hori': [649, 836, 873, 894, 988, 1084, 4240], 'Moss': [651], 'R.A.': [652], '1997;': [658, 938, 1387, 1415, 1462, 1564, 1628, 2049, 2600], '272:': [659], '17810-17814Abstract': [660], '(691)': [668], 'Scholar),': [670, 1681, 1716], 'redirecting': [672], 'function': [674], 'manner': [677], 'expression': [680, 1947], 'prothrombotic': [684], 'genes': [685], 'important': [686], 'chronic': [691], 'apparently': [694], 'diverse': [695], 'macrovascular': [698], 'disease': [699], '(10Schmidt': [702, 4275], 'Mora': [708, 4281], '91:': [716, 755, 792, 827, 4289], '2155-2168Crossref': [717, 4290], '(271)': [720, 4293], '11Schmidt': [723], 'A.-M.': [724], 'Hasu': [725], 'Popov': [727], 'J.H.': [730, 897], 'S.-D.': [732], 'Cao': [735, 846, 875, 986, 1082, 2534, 4250], 'Kuwabara': [737], 'Costache': [739], 'Simionescu': [741, 743], 'Proc.': [747, 784, 819], 'Natl.': [748, 785, 820], 'Acad.': [749, 786, 821], 'Sci.': [750, 787, 822], 'U.': [751, 788, 823, 1993], '8807-8811Crossref': [756], '(292)': [759], '12Wautier': [762], 'J.L.': [763, 1622], 'Wautier': [764, 982, 1078], 'M.P.': [765, 983, 1079], 'G.M.': [769, 958], 'Zoukourian': [770, 978, 1074], 'Capron': [772], 'L.': [773, 901, 1006, 1012, 1102, 1108, 1214, 1220, 1451], 'Chappey': [774, 980, 1076], 'Guillausseau': [780, 984, 1080], 'P.J.': [781, 985, 1081], '7742-7746Crossref': [793], '(336)': [796], '13Yan': [799], 'Chen': [801, 838, 2538, 4242], 'X.': [802], 'Godman': [807], 'Scott': [809], 'C.W.': [810], 'Caputo': [811], 'Frappier': [813], 'Yen': [815], 'S.H.': [816], '7787-7791Crossref': [828], '(541)': [831], '14Schmidt': [834], 'J.F.': [841, 4245], 'Crandall': [842, 4246], '96:': [858, 939, 4262], '1395-1403Crossref': [859, 4263], '(829)': [862, 4266], '15Schmidt': [865], 'Weidman': [867, 1970], 'Lalla': [869], 'Lamster': [879], 'I.': [880, 3640], 'Periodontol.': [882], 'Res.': [883], '31:': [885], '508-515Crossref': [886], '(219)': [889], '16Miyata': [892], 'Ferran': [900, 1013, 1109, 1221], '98:': [910], '1088-1094Crossref': [911], '(277)': [914], '17Bierhaus': [917], 'Illmer': [919], 'Kasper': [921], 'Luther': [923], 'Quehenberger': [925], 'P.': [926, 930, 2005, 2009, 2076], 'Tritschler': [927], 'Wahl': [929, 2004], 'Ziegler': [931, 1998], 'Muller': [933], 'Nawroth': [935, 2008, 2075], 'P.P.': [936], 'Circulation.': [937, 1752], '2262-2271Crossref': [940], '(212)': [943], '18Owen': [946], 'Jr.,': [947], 'W.F.': [948], 'Hou': [949], 'F.F.': [950], 'Stuart': [951], 'R.O.': [952], 'Kay': [953], 'Boyce': [955], 'Chertow': [957], 'Kidney': [961, 1460], 'Int.': [962, 1461, 1901], '1998;': [963, 1023, 1119, 1231, 1437, 1509], '53:': [964], '1365-1373Abstract': [965], '(82)': [973], '19Wautier': [976], 'J.-L.': [977, 1073], '97:': [998, 1094, 2095], '238-243Crossref': [999, 1095], '(509)': [1002, 1098], '20Park': [1005, 1101], 'Raman': [1007, 1103, 1215], 'K.G.': [1008, 1104, 1216], 'Lee': [1009, 1105, 1217], 'K.J.': [1010, 1106, 1218, 1339], 'L.J.': [1014, 1110, 1222], 'Chow': [1015, 1111, 1223], 'W.S.': [1016, 1112, 1224], 'Nat.': [1021, 1117, 1229, 2024], '4:': [1024, 1120, 1232], '1025-1031Crossref': [1025, 1121, 1233], '(1041)': [1028, 1124, 1236], 'recent': [1032, 1295, 1762], 'vivo,': [1045], '(sRAGE),': [1051], 'atherosclerotic': [1064, 1483], 'lesion': [1065], 'development': [1066, 1207, 2171], 'complexity': [1068], 'rodents': [1071, 1491], '(19Wautier': [1072], 'In': [1127, 1292, 1636, 2573, 2877, 3452, 3743, 3786, 3818, 4461], 'latter': [1129, 2575], 'studies,': [1130, 1241], 'analysis': [1131, 3702], 'plasma': [1133, 1142], 'evidence': [1135], 'sRAGE·AGE': [1138], 'complex;': [1139], 'immunoprecipitation': [1140], 'obtained': [1143, 2613, 2915, 3723, 3734], 'from': [1144, 1489, 2916, 3365, 3614, 3732, 3791], 'sRAGE-treated': [1146], 'mice': [1147], 'anti-RAGE': [1149, 1156], 'IgG': [1150, 1157, 2515, 2520, 2615, 2622, 2628, 2805, 2850, 2902, 3130, 3161, 3210, 3393, 3408, 4055, 4166, 4194], 'yielded': [1151], 'species': [1152], 'immunoreactive': [1153], 'or': [1158, 2196, 2747, 2923, 3473, 3558, 3571, 3772, 3836, 4040], 'affinity': [1159, 2517, 2719, 2802, 2899, 3127, 3390], 'purified': [1160, 2518, 2720, 2803, 2900, 3128, 3391, 3860, 3876], 'anti-AGE': [1161], 'IgG,': [1162, 4052], 'suggesting': [1163], 'sRAGE': [1165, 1185, 3556, 3570, 3728, 3739, 4070], 'might': [1166], 'bind': [1167, 1270], 'up': [1168], 'limit': [1171], 'activation': [1176, 1775], 'The': [1181, 2241, 2495, 2999, 3026, 3230, 3322, 4336], 'beneficial': [1182], 'effects': [1183], 'were': [1186, 1400, 2212, 2253, 2293, 2323, 2353, 2386, 2465, 2482, 2521, 2583, 2630, 2684, 2703, 2714, 2758, 2790, 2826, 2839, 2864, 2885, 2914, 2943, 2964, 2993, 3043, 3076, 3094, 3105, 3146, 3174, 3333, 3359, 3421, 3477, 3511, 3527, 3588, 3629, 3751, 3810, 3824, 3855, 3874, 3972, 3998, 4046, 4082, 4106, 4123, 4184, 4203, 4223, 4271, 4319, 4354, 4381, 4402, 4412, 4422, 4441, 4465, 4498], 'independent': [1187], 'alterations': [1189], 'other': [1191, 3819, 4462], 'risk': [1192], 'factors,': [1193], 'hyperglycemia': [1196, 1728], 'hyperlipidemia,': [1198], 'implicating': [1199], 'role': [1201, 1288], 'AGE-RAGE': [1203], 'dysfunction': [1210], '(20Park': [1213], 'These': [1239, 1650, 1824, 2290], 'past': [1240], 'however,': [1242], 'did': [1243, 2644], 'elucidate': [1245], 'AGE(s)': [1248], 'trigger': [1250], 'signal': [1251], 'transduction': [1252], 'mechanisms': [1253], 'upon': [1254, 2841, 2896, 3724, 3735], 'engagement': [1255], 'thus': [1259], 'sought': [1260], 'test': [1262, 2449], 'structures': [1265], 'ability': [1268], 'ECs,': [1279], 'MPs,': [1280], 'VSMCs': [1282], 'order': [1284, 2296], 'determine': [1286, 2407], 'activation.': [1291], 'this': [1293, 2223], 'context,': [1294], 'biochemical': [1296], 'immunohistochemical': [1298], 'accumulate': [1313], '(21Dunn': [1316], 'J.A.': [1317], 'McCance': [1318], 'D.R.': [1319], 'Thorpe': [1320, 1340, 1454, 1666, 1699, 1809], 'S.R.': [1321, 1341, 1455, 1667, 1700, 1810], 'Lyons': [1322, 1695], 'T.J.': [1323, 1424, 1496, 1696], 'Baynes': [1324, 1342, 1458, 1668, 1697], 'J.W.': [1325, 1343, 1459, 1669, 1698, 1812], 'Biochemistry.': [1326, 1344, 1369, 2281], '30:': [1328], '1205-1210Crossref': [1329], '(293)': [1331], '22Reddy': [1334], 'Bichler': [1336], 'Wells-Knecht': [1338], '34:': [1346], '10872-10878Crossref': [1347], '(473)': [1350], '23Ikeda': [1353], 'Higashi': [1355, 2267], 'Sano': [1357, 2269], 'Jinnouchi': [1359, 2271], 'Yoshida': [1361, 2273], 'Ueda': [1365, 2277], '35:': [1371, 2283], '8075-8083Crossref': [1372, 2284], '(417)': [1375, 2287], '24Schleicher': [1378], 'E.D.': [1379, 1407, 2592], 'Wagner': [1380, 1408, 2593], 'Nerlich': [1382, 1410, 2595], 'A.G.': [1383, 1411, 2596], '99:': [1388, 1416, 2601], '457-468Crossref': [1389, 1417, 2602], '(680)': [1392, 1420, 2605], 'Elevated': [1395], 'levels': [1397], 'patients': [1403], '(24Schleicher': [1406, 2591], '25Berg': [1423], 'Clausen': [1425, 1497], 'J.T.': [1426, 1498], 'Torjesen': [1427, 1499], 'P.A.': [1428, 1500], 'Dahl-Jorgensen': [1429, 1501], 'Bangstad': [1431, 1503], 'H.J.': [1432, 1504], 'Hanssen': [1433, 1505], 'K.F.': [1434, 1506], 'Diabetes': [1435, 1507, 1912], 'Care.': [1436, 1508, 1913], '21:': [1438, 1510], '1997-2002Crossref': [1439, 1511], '(72)': [1442, 1514], 'Scholar)': [1444, 2429, 3957, 4295], 'failure': [1447], '(26Degenhardt': [1448], 'T.P.': [1449], 'Grass': [1450], 'Reddy': [1452], 'Diamandis': [1456], 'E.P.': [1457], '52:': [1463, 3990], '1064-1067Abstract': [1464], '(105)': [1470], 'Importantly,': [1473], 'enhanced': [1474, 1723, 1951], 'shown': [1479], 'tissue,': [1482], 'lesions,': [1484], 'glomerular': [1486], 'tissue': [1487, 4002], 'retrieved': [1488, 3373], 'subjects': [1494], '(25Berg': [1495], '27Kume': [1517], 'Takeya': [1519], 'Mori': [1521], 'Suzuki': [1525, 1584], 'Kodama': [1529], 'Miyauchi': [1531], 'Takahashi': [1533], 'Am.': [1535, 1984, 2010], 'Pathol.': [1537, 1986, 2012], '147:': [1539], '654-667PubMed': [1540], '28Meng': [1543], 'Sakata': [1545], 'Takebayashi': [1547], 'Asano': [1549], 'Futata': [1551], 'Nagai': [1553], 'Ikeda': [1555], 'Myint': [1559], 'Atherosclerosis.': [1563], '136:': [1565], '355-365Abstract': [1566], '(53)': [1573], '29Miyata': [1576], 'Ishikawa': [1578], 'Asahi': [1580], 'Tatsumi': [1588], 'Kurokawa': [1590, 1623], 'FEBS': [1592], '1999;': [1594, 1816, 2094], '445:': [1595], '202-206Crossref': [1596], '(90)': [1599], '30Horie': [1602], 'Sugiyama': [1610], 'Sakai': [1612], 'van': [1614], 'Ypersele': [1615], 'de': [1616], 'Strihou': [1617], 'Monnier': [1619], 'V.M.': [1620], '100:': [1629], '2995-3004Crossref': [1630], '(389)': [1633], 'settings,': [1638, 1954], 'adducts': [1640, 2117, 2909], 'co-localized': [1641], 'epitopes,': [1644], 'malondialdehyde': [1647], '4-hydroxynonenal.': [1649], 'observations': [1651], 'consistent': [1653], 'concept': [1656], 'beyond': [1658, 1955], 'mediating': [1660], 'glycoxidation': [1661], '(31Ahmed': [1664], 'M.U.': [1665], '1986;': [1673], '261:': [1674], '4889-4894Abstract': [1675], 'lipid': [1682, 1732], 'itself': [1684], 'generation': [1686], '(32Fu': [1689], 'M.X.': [1690], 'Requena': [1691, 1805], 'J.R.': [1692, 1806, 1808], 'Jenkins': [1693], 'A.J.': [1694], '271:': [1705], '9982-9986Abstract': [1706], '(736)': [1714], 'establishing': [1718], 'likely': [1720], 'link': [1721, 2166], 'between': [1722], 'observed': [1725, 1957, 3758], 'disturbances': [1730], 'metabolism,': [1733], 'common': [1734], 'types': [1737], '1': [1738, 2237, 2343, 2784, 2858, 3168, 3609, 4072, 4197, 4453], '2': [1740, 2338, 2374, 3521, 3576, 3780, 4057, 4178, 4428], '(33Uusitupa': [1742], 'M.I.': [1743], 'Niskanen': [1744], 'L.K.': [1745], 'Siitonen': [1746], 'Voutilainen': [1748], 'Pyorala': [1750], '1990;': [1753], '82:': [1754], '27-36Crossref': [1755], '(267)': [1758], 'Furthermore,': [1761, 2895], 'findings': [1763, 1825, 2165], 'may': [1768, 1826], 'form': [1769], 'directly': [1770], 'consequence': [1773], 'myeloperoxidase-hydrogen': [1778], 'peroxide-chloride': [1779], 'system,': [1780], 'providing': [1782], 'mechanism': [1784], 'conversion': [1786], 'hydroxy': [1788], 'amino': [1789], 'acids': [1790], 'into': [1791, 3841], 'glycoaldehyde,': [1792], 'precursor': [1794], 'steps': [1797], 'leading': [1798], 'formation': [1800], '(34Anderson': [1803], 'M.M.': [1804], 'Crowley': [1807], 'Heinecke': [1811], '104:': [1817], '103-113Crossref': [1818], '(326)': [1821], 'have': [1827], 'direct': [1828], 'implications': [1829], 'characterize': [1834, 2717], 'certain': [1835, 3787, 4060, 4437], 'example,': [1843], 'atherosclerosis,': [1846], 'impaired': [1847], 'wound': [1848], 'healing,': [1849], 'aggressive': [1850], 'periodontal': [1853], '(DRA)': [1858], '(6Miyata': [1859], 'Scholar,35Inoue': [1889], 'Nishikata': [1891], 'Furuya': [1893], 'Takita': [1895], 'Kawamura': [1897], 'Nishikaze': [1899], 'Tissue': [1903], 'React.': [1904], '1985;': [1905], '7:': [1906], '27-33PubMed': [1907], '36Loe': [1910], '16:': [1915], '329-334Crossref': [1916], '(1019)': [1919], 'Consistent': [1922], 'concepts,': [1925], 'placed': [1928], 'milieu': [1935], 'characteristic': [1936], 'AGEs,': [1941], 'CML,': [1944], 'accumulate;': [1945], 'normal': [1959], 'adult': [1960], '(37Brett': [1962], 'D.J.': [1973], 'Neeper': [1974], 'Przysiecki': [1976], 'Migheli': [1980], 'D.M.': [1983], '143:': [1988], '1699-1712PubMed': [1989], '38Ritthaler': [1992], 'Roth': [1994], 'Bierhaus': [1996, 2073], 'Waldherr': [2002], '146:': [2014], '688-694PubMed': [2015], '39Schmidt': [2018], '1:': [2027], '1002-1004Crossref': [2028], '(126)': [2031], '40Soulis': [2034], 'Thallas': [2036], 'V.': [2037], 'Youssef': [2038], 'Gilbert': [2040], 'R.E.': [2041], 'McWilliam': [2042], 'B.G.': [2043], 'Murray-McIntosh': [2044], 'R.P.': [2045], 'Cooper': [2046], 'M.E.': [2047], 'Diabetologia.': [2048], '40:': [2050], '619-628Crossref': [2051], '(202)': [2054], '41Hofmann': [2057], 'M.A.': [2058], 'Drury': [2059], 'Fu': [2061], 'Qu': [2063], 'Taguchi': [2065], 'Lu': [2067], 'Avila': [2069], 'Kambham': [2071], 'Neurath': [2077], 'M.F.': [2078], 'Slattery': [2079, 2532], 'Beach': [2081], 'McClary': [2083], 'Nagashima': [2085, 2540], 'Morser': [2087, 2548], 'Cell.': [2093], '889-901Abstract': [2096], '(1640)': [2104], 'Taken': [2107], 'together,': [2108], 'therefore,': [2109], 'considerations': [2111], 'examination': [2114], 'logical': [2129], 'step.': [2130], 'Here': [2131], 'report': [2133], 'CML-modified': [2135, 2384, 2450, 2474, 2908, 4439], 'transcription': [2154], 'factor': [2155], 'NF-κB,': [2156], 'subsequent': [2158, 3379], 'modulation': [2159], 'Together,': [2163], 'Keyhole': [2188], '(KLH),': [2191], '(BSA),': [2195], '(OVA)': [2198], '(Sigma)': [2199, 2856, 3166, 4195, 4346], '(176': [2200], 'mg': [2201, 2328, 2331, 2335, 2339, 2344, 2358, 2362, 2366, 2370, 2375], 'each': [2203, 2697, 3031, 3061, 3327], 'case),': [2204], 'sodium': [2206, 2215, 2351], 'cyanoborohydride': [2207, 2352], '(28.3': [2208], 'mg;': [2209, 2229], '0.45': [2210], 'm)': [2211, 2231, 3309], 'dissolved': [2213], 'phosphate': [2216, 2952, 2983, 3008, 3021], 'buffer': [2217, 2312, 2687, 2816, 2845, 2872, 3009, 3022, 3137, 3595], '(0.2': [2218, 3234], 'm;': [2219, 2673, 2691, 2986, 3319], 'pH': [2220, 2674, 2692, 2742, 2955, 2987, 3305, 3320, 3492], '7.8);': [2221], 'added': [2225, 2324, 2354, 2732, 2807, 3077, 3410, 4355], 'glyoxylic': [2226, 2261, 2321], 'acid': [2227, 2262, 2322, 2405, 3464], '(14.3': [2228], '0.155': [2230], 'total': [2234], 'volume': [2235, 3370], 'ml': [2238, 2990, 2996], 'per': [2239, 2995, 4221], 'reaction.': [2240], 'mixture': [2242, 3255], 'incubated': [2244, 2310, 3157, 3238, 3495, 3667, 3675, 4112, 4130, 4189, 4423, 4442], '24': [2246], 'h': [2247, 2753, 2785, 2821, 2859, 2947, 3119, 3141, 3169, 3498, 3522, 3577, 3781, 4073, 4101, 4179, 4198, 4368, 4429, 4454], 'at': [2248, 2754, 2786, 2808, 2822, 2860, 2948, 3120, 3142, 3170, 3239, 3261, 3499, 3523, 3578, 4102, 4119, 4153, 4180, 4199, 4369, 4430, 4455], '37': [2249, 3143, 3171, 3240, 3524, 3579, 4181, 4200, 4370, 4431, 4456], '°C.': [2250, 2788, 2824, 2862, 3144, 3172, 3501, 3525, 3580, 4104, 4182, 4201], 'Control': [2251], 'prepared': [2254, 2522, 2580, 2616], 'under': [2255, 3245], 'same': [2257], 'conditions,': [2258], 'except': [2259, 2316], 'omitted': [2264], '(23Ikeda': [2265], 'published': [2291], 'methods': [2292], 'modified': [2294, 2414], 'prepare': [2298], 'range': [2302], 'follows:': [2307, 2326, 2356, 2627], 'protein': [2308, 2501, 3070], 'exactly': [2313], 'above,': [2315, 3011], 'varying': [2318, 2348, 3348], 'amounts': [2319, 2349], '10': [2327, 3277, 3794, 4090, 4117], '(0.108m),': [2329], '7': [2330], '(0.076': [2332], 'm),': [2333, 2337, 2341, 2360, 2364, 2368, 2372, 2377], '4': [2334, 2755, 2949, 3118, 3262, 3500, 4103, 4367], '(0.043': [2336], '(0.0217': [2340], '(0.0108': [2345], 'm);': [2346], 'concomitantly': [2347], '19.8': [2357], '(0.3152': [2359], '14.1': [2361], '(0.225': [2363], '7.1': [2365, 2956], '(0.1125': [2367], '3.5': [2369], '(0.0556': [2371], '(0.0318': [2376], 'respectively,': [2378], 'previously.': [2381], 'Preparations': [2382], 'extensively': [2387, 3148, 3176, 3257, 3295], 'dialyzedversus': [2388, 2707], '(PBS)': [2391], 'characterized': [2393, 2524, 3882, 3975], 'percent': [2395], 'modification': [2396], 'determined': [2398, 3034, 3044, 3716, 4231], 'employment': [2401], '2,4,6-trinitrobenzene': [2403], 'sulfonic': [2404], 'difference': [2409], 'lysine': [2411], 'residues': [2412], 'versus': [2415, 3259, 3338], 'unmodified': [2416, 2893, 3475], 'preparations': [2417, 2502], '(42Habeeb': [2418], 'A.F.': [2419], 'Anal.': [2420], 'Biochem.': [2421], '1966;': [2422], '14:': [2423], '328-336Crossref': [2424], '(1959)': [2427], 'gas': [2432], 'chromatography-mass': [2433], 'spectroscopy': [2434], '(43Woo': [2435], 'Chang': [2437], 'Chromatogr.': [2440], '638:': [2442], '97-107Crossref': [2443], '(21)': [2445], 'To': [2448, 2722], '0.8': [2452, 2968], 'mmol': [2453, 2460], 'CML/mol': [2455, 2462], 'Lys,': [2457, 2464], 'CML-OVA,': [2458], '33': [2459], 'diluted': [2466], '1:40': [2467], 'native': [2469, 2475, 4041], 'OVA': [2470], 'PBS.': [2472], 'All': [2473], 'proteins,': [2476, 3850], 'antibodies/F(ab′)2': [2477], 'fragments,': [2478], 'control': [2480, 3371], 'devoid': [2483], 'endotoxin': [2485, 2498], 'prior': [2486, 3782, 3958, 4031, 4074, 4433, 4458], 'experiments': [2488, 4497], 'chromatography': [2490], 'onto': [2491, 2632, 2655, 2973, 3273, 3479], 'Detox-igel': [2492], 'columns': [2493, 2974, 3795], '(Pierce).': [2494, 2617], 'level': [2496], 'all': [2500, 3453], '(concentration': [2503], 'range,': [2504], '2–6': [2505], 'mg/ml)': [2506], 'less': [2508, 3754], 'than': [2509, 3755], '3': [2510, 2812, 2820], 'pg/ml': [2511], '(Sigma).': [2512, 2876, 3229, 4406], 'Anti-human': [2513], 'anti-CML': [2519, 2804, 2901, 3129, 3392], 'previously': [2527, 2639, 2661, 2980, 3282], '(44Hori': [2528], 'J.X.': [2539], 'Lundh': [2542], 'E.R.': [2543], 'Vijay': [2544], 'Nitecki': [2546], '270:': [2558], '25752-25761Abstract': [2559], '(1044)': [2567], 'Scholar': [2569], '24,': [2571], 'respectively).': [2572], 'case,': [2576], 'CML-BSA': [2577, 3351, 3710], 'CML-KLH': [2579], 'above': [2582, 2818, 3058, 3132, 3179, 3346, 3367], 'employed': [2584, 2994, 3395, 3825, 4348, 4493], 'immunize': [2586], 'New': [2587], 'Zealand': [2588], 'White': [2589], 'rabbits': [2590], 'After': [2608, 2665, 2749, 2961, 3087, 3289, 4078, 4156, 4364], '6–12': [2609], 'weeks,': [2610], 'Affinity': [2618], 'purification': [2619], 'fractions': [2623, 2629, 2683, 2702, 3042, 3332], 'performed': [2625, 2715, 3055, 3125, 3187, 3202, 3315, 3342, 3544, 3603, 3778, 3811, 4176, 4272], 'chromatographed': [2631, 2654, 2972, 3272], 'Affi-Gel': [2633, 2656, 2976, 3276], '15': [2634, 2657], 'resin': [2635, 2649, 2978, 2992, 3000, 3274, 3292], '(Bio-Rad),': [2636], 'had': [2638, 2660, 3281, 4397], 'adsorbed': [2640, 2663, 3284], 'KLH.': [2641], 'Material': [2642, 3502], 'adhere': [2646], 'collected': [2651], 'subsequently': [2653], '(Bio-Rad)': [2658, 2979, 3278], 'been': [2662, 3283], 'CML-BSA.': [2664, 3742, 3763], 'extensive': [2666], 'washing': [2667, 3381, 3594, 4157], '(Tris,': [2671, 3302], '0.02': [2672, 2690, 2985, 3303, 3318], '7.4,': [2675], 'NaCl,': [2677, 3307], '0.1m)': [2678], 'containing': [2679, 2688, 2775, 2794, 2846, 2975, 3023, 3151, 3225, 3275, 3517, 3532, 3547, 3607, 3847, 4086, 4133, 4303, 4325], 'Tween': [2680, 2795, 3152], '20': [2681, 2796, 3153], '(0.05%),': [2682], 'eluted': [2685, 3017, 3364, 3790], 'glycine,': [2689, 3317], '2.5.A': [2693], '280': [2694, 3028, 3324], 'nm': [2695, 3029, 3325, 3426, 4220], 'fraction': [2698, 3032, 3328], 'determined;': [2700, 3330], 'positive': [2701, 3041, 3331, 4350], 'immediately': [2704, 3334, 4030], 'neutralized': [2705, 3335], 'saline.': [2709], 'Enzyme-linked': [2710], 'assays': [2712, 4270], '(ELISA)': [2713], 'antibodies.': [2721], 'wells': [2723, 2757, 2768, 3481, 3505, 3587, 3616, 3666, 3674, 4004], 'plastic': [2725, 3357, 3483], 'dishes': [2726, 3358, 3484], '(Maxisorp,': [2727, 3485], 'Nunc,': [2728], 'Naperville,': [2729], 'IL)': [2730], '5': [2733, 2989, 3212], 'μg': [2734, 3068, 4487], 'following': [2737], 'bicarbonate/carbonate': [2740, 3490], 'buffer,': [2741, 2953, 2984, 3180, 3491], '9.6:': [2743], 'BSA,': [2744, 3749], 'KLH,': [2745], 'CML-BSA,': [2746, 2905], 'CML-KLH.': [2748], 'incubation': [2750, 2842, 2897, 3222, 3438, 3514, 4094, 4365], '16': [2752, 2946, 3497, 4100], '°C,': [2756, 4371], 'washed': [2759, 2791, 2827, 2865, 3002, 3147, 3175, 3294, 3528, 3589, 4107, 4125, 4185, 4204], 'PBS': [2761, 2774, 2793, 3224, 3260, 3516, 3531, 3546, 4110, 4128, 4132], 'then': [2763, 2833, 2971, 3237, 3271, 3875, 4022, 4389], 'unoccupied': [2764, 3509], 'sites': [2765, 2834, 3101, 3413, 3510, 4145, 4208], 'blocked': [2769, 3106, 3512], 'presence': [2772, 3109, 3561, 3680, 3761], 'BSA': [2776, 3518, 3548, 4134], '(1%)': [2777, 3519], 'goat': [2779, 2848, 3159, 3406], '(5%;': [2781], 'Sigma)': [2782], '25': [2787, 2823, 2861], 'Wells': [2789, 2825, 2863, 3355, 3526, 4105, 4122, 4183, 4202], '(0.05%)': [2797], 'primary': [2799, 2836, 3417], 'antibody,': [2800, 3389, 3418], 'concentration': [2810, 3553, 4068], 'μg/ml': [2813], 'blocking': [2815, 2844], 'five': [2828, 2866, 3591, 4205], 'times': [2829, 2867, 3592, 4187, 4206], 'PBS,': [2831, 3215, 4160], 'antibody': [2837, 3184, 4210], 'binding': [2838, 3185, 3415, 3541, 3627, 3708, 3721, 3725, 3736, 3746, 3784, 3807, 3964, 4144, 4211], 'identified': [2840, 2891], 'peroxidase-conjugated': [2847, 4191], 'anti-rabbit': [2849, 3160, 3407], 'according': [2851, 3631], "manufacturer's": [2854], 'instructions': [2855], 'developed': [2869, 3422], 'citrate': [2871], 'containingo-phenylenediamine/H2O2': [2873], 'instructed': [2875], 'assays,': [2879], 'only': [2880], 'highly': [2886], 'reactive;': [2887], 'no': [2888], 'reactivity': [2889], 'versusnative,': [2892], 'proteins.': [2894], 'excess': [2904, 3566, 3682], 'immunoreactivity': [2906], 'abolished.': [2911], 'Plasma': [2912], 'samples': [2913, 2963], 'donors': [2918], 'age-matched': [2924], 'healthy': [2925], 'controls': [2926, 3809], 'accordance': [2928], 'procedures': [2931], 'Institutional': [2934], 'Review': [2935], 'Board': [2936], 'Columbia': [2938], 'University.': [2939], 'Samples': [2940], '(2': [2941, 4173, 4486], 'ml)': [2942], 'dialyzed': [2944, 3258, 3337], '°C': [2950, 3241, 3263, 4432, 4457], '0.02m;': [2954], '(total': [2957, 3664], 'volume,': [2958], '4,000': [2959], 'ml).': [2960], 'dialysis,': [2962], 'subjected': [2965, 3217], 'filtration,': [2967], 'μm,': [2969], 'blue': [2977], 'equilibrated': [2981], '7.1;': [2988], 'plasma.': [2998], '2.5': [3004], 'column': [3005], 'volumes': [3006, 3298, 3384, 3814], 'application': [3019], 'NaCl': [3024], '(1.4m).': [3025], 'A': [3027, 3323, 3539, 3693], '(Ultraspec': [3035], 'Plus,': [3036], 'Amersham': [3037], 'Pharmacia': [3038, 3085, 3194, 3624, 3870], 'Biotech),': [3039], 'SDS-PAGE': [3046, 3064, 3884], 'followed': [3047, 4092], 'staining': [3049], 'silver': [3051], '(Bio-Rad).': [3052, 3099], 'Immunoblotting': [3053, 3123], 'employing': [3056, 3188, 3316, 3347, 4164, 4481], 'material;': [3059], 'lane': [3062], 'gels': [3065, 3093], '(8%),': [3066], '30': [3067, 4151], 'added.': [3072], 'Simultaneously,': [3073], 'marker': [3074], 'means': [3080], 'assess': [3082], '≈kDa': [3083], '(Amersham': [3084, 3193, 3623, 3869], 'Biotech).': [3086, 3195, 3625, 3871], 'separation,': [3089], 'contents': [3090], 'transferred': [3095], 'nitrocellulose': [3097], 'membranes': [3098, 3104, 3156], 'Unoccupied': [3100], 'nonfat': [3111], 'dry': [3112, 4138], 'milk': [3113, 3136, 4139], 'TBS': [3115, 3150], '(13.5%)': [3116], 'room': [3121, 4120, 4154], 'temperature.': [3122, 4121, 4155], 'using': [3126, 3203, 3698, 3879], '(14.2': [3133], 'μg/ml)': [3134, 3397, 4174], '(5%)': [3138], '1.5': [3140], 'Membranes': [3145, 3173], '(0.1%)': [3154], 'labeled': [3162], 'horseradish': [3164], 'peroxidase': [3165], 'visualization': [3182], 'ECL': [3190], 'detection': [3191], 'system': [3192], 'Quantitative': [3196], 'evaluation': [3197], 'band': [3199], 'intensity': [3200], 'Molecular': [3204, 3537], 'Dynamics/ImageQuant': [3205], '(Foster': [3206], 'City,': [3207], 'CA).': [3208, 3706, 4311], 'Human': [3209, 3429, 3829, 3966], '(Sigma),': [3211], 'mg/ml': [3213], 'nonenzymatic': [3219], 'd-ribose,': [3226], '0.025': [3227], 'm': [3228], 'solution': [3231, 3606], 'sterile-filtered': [3233], 'μm)': [3235], '6': [3243, 4079], 'weeks': [3244], 'aerobic': [3246], 'conditions.': [3247], 'At': [3248, 3581], 'time,': [3253, 3586], 'remove': [3265], 'unreacted': [3266], 'ribose.': [3267], 'This': [3268], 'material': [3269, 3363, 3461, 3601, 3789], 'recombinant': [3285, 3431], 'incubation,': [3290], '10-column': [3297, 3383], 'm,': [3304], '7.4;': [3306], '0.1': [3308], 'elution': [3311, 3375, 3598], 'bound': [3313, 3600, 3662], 'components': [3314, 3378], '2.5.': [3321], 'TBS.': [3339], 'ELISA': [3340, 4163], 'essentially': [3343], 'concentrations': [3349, 4037], 'standard': [3353], 'reference.': [3354], 'coated': [3360], 'AGE-IgG,': [3362], 'column,': [3368, 3864], '(buffer': [3372], 'after': [3374, 3455], 'RAGE-binding': [3377], 'glycine': [3386, 3816], 'buffer).': [3387], 'Primary': [3388], '(3': [3396], 'identify': [3399], 'CML-immunoreactivity': [3400], 'various': [3403], 'fractions.': [3404], 'Finally,': [3405], 'detect': [3412], 'plates': [3420], 'above.A': [3424], '490': [3425, 4219], 'detected.': [3428], 'radiolabeled': [3434, 3460, 3712, 3727, 3738], '125I': [3436], 'IODO-BEADS': [3440], '(Pierce)': [3441], 'activity': [3445, 4229], '≈4,000': [3447], '5,000': [3449], 'cpm/ng': [3450], 'protein.': [3451], 'cases,': [3454, 4061, 4438], 'radioiodination,': [3456], 'precipitation': [3457], 'trichloroacetic': [3463], 'exceeded': [3465], '90%.': [3466], 'indicated': [3472, 3552, 3573, 3774, 4036, 4067, 4426, 4445], 'native,': [3474], 'loaded': [3478], 'Nunc)': [3486], '(5': [3487, 4360], 'ng/well)': [3488], '9.6,': [3493], 'aspirated,': [3507], 'twice': [3529, 4108, 4126], 'octyl': [3533], 'β-glucoside': [3534], '(0.005%)': [3535], '(Roche': [3536], 'Biochemicals).': [3538], 'radioligand': [3540, 3963], '(0.2%)': [3549], '125I-human': [3555], 'alone': [3557], '50-fold': [3564], 'molar': [3565, 4446], 'unlabeled': [3568, 3683, 3803, 3827], 'competitor': [3574, 3776, 3804], 'rapidly': [3590], 'above;': [3597, 4216], 'heparin,': [3608], 'mg/ml.': [3610], 'Solution': [3611], 'aspirated': [3613], 'counted': [3618, 4413], 'gamma': [3621], 'counter': [3622], 'Equilibrium': [3626], 'data': [3628], 'analyzed': [3630], 'equation': [3634], 'Klotz': [3636], 'Hunston': [3638, 3641], '(45Klotz': [3639], '1984;': [3646], '259:': [3647], '10060-10062Abstract': [3648], 'Scholar):B': [3654], '=': [3655], 'nKA/1': [3656], '+': [3657], 'KA,': [3658], 'whereB': [3659], 'indicates': [3660, 3688, 3694], 'specifically': [3661], 'ligand': [3663, 3696], 'binding,': [3665, 3673], 'tracer': [3669, 3677], 'alone,': [3670], 'minus': [3671], 'nonspecific': [3672, 3720, 4143], 'material),': [3684], 'nindicates': [3685], 'sites/cell,': [3686], 'K': [3687], 'dissociation': [3690], 'constant,': [3691], 'free': [3695], 'concentration)': [3697], 'nonlinear': [3699], 'least': [3700], 'squares': [3701], '(Prism;': [3703], 'San': [3704, 4014], 'Diego,': [3705, 4015], 'Specific': [3707], 'further': [3715], 'subtraction': [3718], '(counts': [3722], 'immobilized': [3730, 3741, 3748], 'BSA)': [3731], 'case': [3745], 'counts': [3750], 'negligible': [3752], '10%': [3756], 'Where': [3764, 4043, 4419], 'indicated,': [3765, 4044, 4420], 'pretreatment': [3766], 'either': [3768], 'antibodies,': [3769], 'assay.': [3785, 3965, 4460], 'experiments,': [3788, 3820, 4463], 'RAGE-Affi-Gel': [3793], '(after': [3796], 'passage': [3797], 'AGE-IgG)': [3799], 'assay;': [3808, 4435], 'equal': [3813], 'buffer.': [3817], 'isolated': [3821, 3973], 'domains': [3823, 3873], 'competitors.': [3828], 'cDNA': [3831], 'encoding': [3832, 4470], 'V,': [3834], 'C1,': [3835], 'C2': [3837], 'inserted': [3840], 'theEcoRI': [3842], 'pGEX4T': [3845], 'vector': [3846], 'GST.': [3848], 'Fusion': [3849], 'V-GST,': [3851], 'C1-GST,': [3852], 'C2-GST,': [3854], 'expressed': [3856], 'Escehrichia': [3858], 'coli,': [3859], 'glutathione-Sepharose': [3863, 3880], 'cleaved': [3866], 'thrombin': [3868], 'homogeneity': [3878], 'amino-terminal': [3886], 'sequencing': [3887], 'testing': [3960], '(HUVECs)': [3971], '(46Jaffe': [3978], 'Nachman': [3980], 'Becker': [3982], 'Minick': [3984], '1973;': [3989], '2745-2756Crossref': [3991], '(6180)': [3994], 'Cells': [3997, 4407], 'cultured': [3999], '96-well': [4001], 'culture-treated': [4003], '(Corning,': [4005], 'Corning,': [4006], 'NY)': [4007], 'growth': [4011], 'medium': [4012, 4020, 4085, 4324], '(Clonetics,': [4013], 'CA)': [4016, 4172, 4485], 'until': [4017], 'achieving': [4018], 'confluence;': 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[4235], '(14Schmidt': [4238], 'Chemotaxis': [4269], '48-well': [4297], 'microchemotaxis': [4298], 'chambers': [4299], '(Neuro-Probe,': [4300], 'Bethesda,': [4301], 'MD)': [4302], 'polycarbonate': [4305], 'membrane': [4306, 4380, 4387, 4401], '(8': [4307], 'μm;': [4308], 'Nucleopore,': [4309], 'Pleasanton,': [4310], 'cells,': [4313], 'bear': [4315], 'grown': [4320], 'suspension': [4322], 'RPMI': [4326], '1640,': [4327], 'fetal': [4328], '(10%),': [4331], 'antibiotics': [4333], 'Sciences).': [4335], 'lower': [4337], 'chamber': [4338, 4359], 'contained': [4339], 'chemotactic': [4341], 'stimulus': [4342], 'indicated.': [4344], 'N-Formyl-Met-Leu-Phe': [4345], 'control.': [4351], 'upper': [4358, 4376], '×': [4361], '104': [4362], 'cells/well).': [4363], 'nonmigrating': [4372], 'gently': [4382], 'scraped': [4383], 'removed;': [4385], 'methanol': [4392], '(100%),': [4393], 'migrated': [4398], 'through': [4399], 'stained': [4403], 'Giemsa': [4405], 'nine': [4409], 'high-powered': [4410], 'fields': [4411], 'mean': [4415], '±': [4416], 'S.E.': [4417], 'reported.': [4418], 'F(ab′)2for': [4427], 'excesses': [4447], 'transfected': [4466], 'construct': [4469], 'cytosolic': [4476], '(tail)': [4478], 'deleted': [4480], 'superfect': [4482], '(Qiagen,': [4483], 'Valencia,': [4484], 'DNA/ml': [4488], 'medium);': [4489], 'pcDNA3': [4490], '(Invitrogen)': [4491], 'vector.': [4495], 'Stimulation': [4496]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2106697731', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 26}, {'year': 2019, 'cited_by_count': 25}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 21}, {'year': 2016, 'cited_by_count': 26}, {'year': 2015, 'cited_by_count': 34}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 40}, {'year': 2012, 'cited_by_count': 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