Publication Information

{'id': 'https://openalex.org/W2106548400', 'doi': 'https://doi.org/10.1124/mol.110.069393', 'title': 'Celecoxib Antagonizes the Cytotoxicity of Cisplatin in Human Esophageal Squamous Cell Carcinoma Cells by Reducing Intracellular Cisplatin Accumulation', 'display_name': 'Celecoxib Antagonizes the Cytotoxicity of Cisplatin in Human Esophageal Squamous Cell Carcinoma Cells by Reducing Intracellular Cisplatin Accumulation', 'publication_year': 2010, 'publication_date': '2010-12-21', 'ids': {'openalex': 'https://openalex.org/W2106548400', 'doi': 'https://doi.org/10.1124/mol.110.069393', 'mag': '2106548400', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21177414'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1124/mol.110.069393', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62949411', 'display_name': 'Molecular Pharmacology', 'issn_l': '0026-895X', 'issn': ['0026-895X', '1521-0111'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316283', 'host_organization_name': 'American Society for Pharmacology and Experimental Therapeutics', 'host_organization_lineage': ['https://openalex.org/P4310316283'], 'host_organization_lineage_names': ['American Society for Pharmacology and Experimental Therapeutics'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100784535', 'display_name': 'Le Yu', 'orcid': 'https://orcid.org/0000-0002-9773-1162'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Le Yu', 'raw_affiliation_strings': ['Southern medical university'], 'affiliations': [{'raw_affiliation_string': 'Southern medical university', 'institution_ids': ['https://openalex.org/I58200834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100678185', 'display_name': 'Minghui Chen', 'orcid': 'https://orcid.org/0000-0002-0316-2289'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Minghui Chen', 'raw_affiliation_strings': ['Southern medical university'], 'affiliations': [{'raw_affiliation_string': 'Southern medical university', 'institution_ids': ['https://openalex.org/I58200834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100341910', 'display_name': 'Zhijie Li', 'orcid': 'https://orcid.org/0000-0002-5445-7976'}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhijie Li', 'raw_affiliation_strings': ['Chinese University of Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Chinese University of Hong Kong', 'institution_ids': ['https://openalex.org/I177725633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103257818', 'display_name': 'Jing Wen', 'orcid': 'https://orcid.org/0000-0002-5261-5731'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jing Wen', 'raw_affiliation_strings': ['Sun Yat-Sen University'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-Sen University', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066070080', 'display_name': 'Jianhua Fu', 'orcid': 'https://orcid.org/0000-0002-8544-1862'}, 'institutions': [{'id': 'https://openalex.org/I4210086757', 'display_name': 'Thoracic Surgery Foundation', 'ror': 'https://ror.org/0009jge67', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210086757']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jianhua Fu', 'raw_affiliation_strings': ['Thoracic Surgery'], 'affiliations': [{'raw_affiliation_string': 'Thoracic Surgery', 'institution_ids': ['https://openalex.org/I4210086757']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100611889', 'display_name': 'Dan Guo', 'orcid': 'https://orcid.org/0000-0002-4032-3467'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dan Guo', 'raw_affiliation_strings': ['Southern medical university'], 'affiliations': [{'raw_affiliation_string': 'Southern medical university', 'institution_ids': ['https://openalex.org/I58200834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101656020', 'display_name': 'Yong Jiang', 'orcid': 'https://orcid.org/0000-0002-0163-5089'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yong Jiang', 'raw_affiliation_strings': ['Southern medical university'], 'affiliations': [{'raw_affiliation_string': 'Southern medical university', 'institution_ids': ['https://openalex.org/I58200834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100513876', 'display_name': 'Shuguang Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuguang Wu', 'raw_affiliation_strings': ['Southern medical university'], 'affiliations': [{'raw_affiliation_string': 'Southern medical university', 'institution_ids': ['https://openalex.org/I58200834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111893061', 'display_name': 'Chi-Hin Cho', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chi-Hin Cho', 'raw_affiliation_strings': ['Chinese University of Hong Kong'], 'affiliations': [{'raw_affiliation_string': 'Chinese University of Hong Kong', 'institution_ids': ['https://openalex.org/I177725633']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088170766', 'display_name': 'Shuwen Liu', 'orcid': 'https://orcid.org/0000-0001-6346-5006'}, 'institutions': [{'id': 'https://openalex.org/I58200834', 'display_name': 'Southern Medical University', 'ror': 'https://ror.org/01vjw4z39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I58200834']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuwen Liu', 'raw_affiliation_strings': ['Southern medical university'], 'affiliations': [{'raw_affiliation_string': 'Southern medical university', 'institution_ids': ['https://openalex.org/I58200834']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.301, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.818073, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '79', 'issue': '3', 'first_page': '608', 'last_page': '617'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10163', 'display_name': 'Metal complexes synthesis and properties', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10163', 'display_name': 'Metal complexes synthesis and properties', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/celecoxib', 'display_name': 'Celecoxib', 'score': 0.555803}], 'concepts': [{'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.9119655}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.792241}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5959016}, {'id': 'https://openalex.org/C2776467144', 'wikidata': 'https://www.wikidata.org/wiki/Q408801', 'display_name': 'Celecoxib', 'level': 2, 'score': 0.555803}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.52720577}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.52436304}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.5229581}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49527374}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26866758}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.25890803}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22103316}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20306599}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.19287881}], 'mesh': [{'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000068579', 'descriptor_name': 'Celecoxib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004938', 'descriptor_name': 'Esophageal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020287', 'descriptor_name': 'In Situ Nick-End Labeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1124/mol.110.069393', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62949411', 'display_name': 'Molecular Pharmacology', 'issn_l': '0026-895X', 'issn': ['0026-895X', '1521-0111'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316283', 'host_organization_name': 'American Society for Pharmacology and Experimental Therapeutics', 'host_organization_lineage': ['https://openalex.org/P4310316283'], 'host_organization_lineage_names': ['American Society for Pharmacology and Experimental Therapeutics'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21177414', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1598952686', 'https://openalex.org/W1977636518', 'https://openalex.org/W1987365971', 'https://openalex.org/W1993228606', 'https://openalex.org/W2005247755', 'https://openalex.org/W2012890445', 'https://openalex.org/W2014308148', 'https://openalex.org/W2019663390', 'https://openalex.org/W2036319147', 'https://openalex.org/W2040311792', 'https://openalex.org/W2044376109', 'https://openalex.org/W2052351422', 'https://openalex.org/W2062471302', 'https://openalex.org/W2074715236', 'https://openalex.org/W2078534963', 'https://openalex.org/W2096510511', 'https://openalex.org/W2102408917', 'https://openalex.org/W2105372476', 'https://openalex.org/W2113689159', 'https://openalex.org/W2117053852', 'https://openalex.org/W2119858046', 'https://openalex.org/W2122129320', 'https://openalex.org/W2123099168', 'https://openalex.org/W2126530663', 'https://openalex.org/W2130177169', 'https://openalex.org/W2142158739', 'https://openalex.org/W2142323325', 'https://openalex.org/W2143493608', 'https://openalex.org/W2148122132', 'https://openalex.org/W2150036000', 'https://openalex.org/W2152988065', 'https://openalex.org/W2162517111', 'https://openalex.org/W2170454539', 'https://openalex.org/W2326639001', 'https://openalex.org/W2408353708', 'https://openalex.org/W2418654556', 'https://openalex.org/W4243457910', 'https://openalex.org/W97409349'], 'related_works': ['https://openalex.org/W364918769', 'https://openalex.org/W2379455167', 'https://openalex.org/W2357943637', 'https://openalex.org/W2349779113', 'https://openalex.org/W2257639774', 'https://openalex.org/W2108767960', 'https://openalex.org/W2035718411', 'https://openalex.org/W2012767167', 'https://openalex.org/W2002655626', 'https://openalex.org/W1723369229'], 'abstract_inverted_index': {'High': [0], 'cyclooxygenase': [1], '2': [2], '(COX-2)': [3], 'expression': [4], 'has': [5], 'been': [6], 'reported': [7], 'to': [8, 35, 48, 81, 113], 'be': [9, 242], 'clinically': [10], 'associated': [11, 146], 'with': [12, 147, 224, 235, 239, 244], 'reduced': [13], 'cisplatin-based': [14], 'therapy': [15], 'efficacy': [16], 'in': [17, 27, 54, 97, 189, 191, 229, 237], 'esophageal': [18, 56, 193], 'cancer.': [19], 'However,': [20], 'the': [21, 37, 43, 51, 62, 86, 115, 133, 159, 204], 'benefit': [22], 'of': [23, 39, 45, 74, 106, 118, 136, 143, 161, 164, 206], 'including': [24], 'COX-2-selective': [25, 87], 'inhibitors': [26, 41, 66, 88], 'therapeutic': [28], 'regimens': [29], 'remains': [30], 'uncertain.': [31], 'Thus,': [32], 'we': [33], 'sought': [34], 'determine': [36], 'effects': [38, 117], 'COX': [40, 65], 'on': [42, 140], 'cytotoxicity': [44, 94, 205], 'cisplatin': [46, 144, 150, 172, 185, 207, 211, 225, 240], 'and': [47, 71, 90, 95, 101, 120, 138, 152, 212], 'further': [49], 'explore': [50], 'mechanism': [52], 'involved': [53], 'human': [55], 'squamous': [57], 'cell': [58], 'carcinoma': [59], 'cells.': [60], 'Among': [61], 'four': [63], 'tested': [64], '[celecoxib,': [67], '4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide': [68], '(SC-236),': [69], 'nimesulide,': [70], 'indomethacin],': [72], 'all': [73], 'which': [75], 'substantially': [76], 'suppressed': [77], 'prostaglandin': [78], 'E<sub>2</sub>': [79], 'production': [80], 'a': [82], 'similar': [83], 'extent;': [84], 'only': [85], 'celecoxib': [89, 119, 137, 187, 202, 227, 236], 'SC-236': [91, 139], 'antagonized': [92], 'cisplatin-induced': [93], 'apoptosis': [96], 'both': [98], 'cisplatin-resistant': [99], 'cells': [100], 'their': [102, 124], 'wild-type': [103], 'counterparts.': [104], 'Knockdown': [105], 'COX-2': [107], 'by': [108, 158, 208], 'small': [109], 'interference': [110], 'RNA': [111], 'failed': [112], 'mimic': [114], 'antagonizing': [116, 134], 'SC-236,': [121], 'implying': [122], 'that': [123, 132, 201], 'action': [125, 142], 'is': [126], 'COX-2-independent.': [127], 'Further': [128], 'mechanistic': [129], 'analysis': [130], 'revealed': [131], 'effect': [135, 222], 'cytotoxic': [141], 'was': [145], 'decreased': [148, 170], 'whole-cell': [149], 'accumulation': [151], 'DNA': [153, 213], 'platination.': [154, 214], 'Reduced': [155], 'influx,': [156], 'accompanied': [157], 'reduction': [160], 'protein': [162], 'level': [163], 'copper': [165], 'transporter': [166], '1,': [167], 'accounts': [168], 'for': [169], 'intracellular': [171, 210], 'accumulation.': [173], 'In': [174], 'addition,': [175], 'combined': [176], 'treatment': [177, 217], 'did': [178], 'not': [179], 'elicit': [180], 'greater': [181], 'antitumor': [182], 'activity': [183], 'than': [184], 'or': [186, 226], 'monotherapy': [188, 228], 'vivo': [190], 'an': [192], 'cancer': [194], 'xenograft': [195], 'model.': [196], 'Collectively,': [197], 'these': [198], 'data': [199], 'demonstrate': [200], 'antagonizes': [203], 'decreasing': [209], 'The': [215], 'combination': [216, 238], 'also': [218], 'shows': [219], 'no': [220], 'beneficial': [221], 'compared': [223], 'vivo.': [230], 'Therefore,': [231], 'current': [232], 'clinical': [233], 'trials': [234], 'should': [241], 'approached': [243], 'caution.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2106548400', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-08T13:01:06.069353', 'created_date': '2016-06-24'}