Title: Altered expression of KCNK9 in colorectal cancers
Abstract: APMISVolume 112, Issue 9 p. 588-94 Altered expression of KCNK9 in colorectal cancers† CHANG JAE KIM, CHANG JAE KIM Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorYONG GU CHO, YONG GU CHO Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorSEONG WHAN JEONG, SEONG WHAN JEONG Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorYOUNG SIL KIM, YOUNG SIL KIM Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorSU YOUNG KIM, SU YOUNG KIM Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorSUK WOO NAM, SUK WOO NAM Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorSUG HYUNG LEE, SUG HYUNG LEE Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorNAM JIN YOO, NAM JIN YOO Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorJUNG YOUNG LEE, JUNG YOUNG LEE Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorWON SANG PARK, Corresponding Author WON SANG PARK Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaWon Sang Park, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea. e-mail: [email protected]Search for more papers by this author CHANG JAE KIM, CHANG JAE KIM Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorYONG GU CHO, YONG GU CHO Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorSEONG WHAN JEONG, SEONG WHAN JEONG Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorYOUNG SIL KIM, YOUNG SIL KIM Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorSU YOUNG KIM, SU YOUNG KIM Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorSUK WOO NAM, SUK WOO NAM Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorSUG HYUNG LEE, SUG HYUNG LEE Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorNAM JIN YOO, NAM JIN YOO Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorJUNG YOUNG LEE, JUNG YOUNG LEE Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaSearch for more papers by this authorWON SANG PARK, Corresponding Author WON SANG PARK Departments of Pathology and Biochemistry, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, KoreaWon Sang Park, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea. e-mail: [email protected]Search for more papers by this author First published: 13 December 2004 https://doi.org/10.1111/j.1600-0463.2004.apm1120905.xCitations: 47 † Received July 11, 2003. Accepted August 19, 2004. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract K+ channels have been reported to be involved in the proliferation of many types of cells, including some human carcinoma and tumor cell lines. KCNK9, a TASK channel, is amplified and overexpressed in several types of human cancer. In the present study, we examined the expression and somatic mutations of KCNK9 in 124 colorectal cancers by immunohistochemistry using tissue microarray and PCR-SSCP. Immunopositivity was observed in 57 (46.0%) of 124 colorectal cancers. Clinically, KCNK9 was immunopositive in 4 (30.7%) of 13 cases which were stage A, 26 (55.3%) of 47 which were stage B, 23 (41.1%) of 56 which were stage C, and 4 (50%) of 8 which were stage D. Statistically, KCNK9 protein expression was not related to tumor stage (Bartholomew test, p>0.05) and lymph node metastasis (Chi-Square test, p=0.8338). In the mutation study of the KCNK9 gene, we found only one sequence variation (ACG→ACC, Thr→Thr) at codon 170 both in corresponding normal and tumor DNAs. These results indicate that overexpression rather than mutation of the KCNK9 gene may contribute to the development of colorectal cancers and suggest that the development of KCNK9-targeted agents may provide new possibilities in the treatment of colorectal cancer. REFERENCES 1 Wonderline WF, Woodfork KA, Stroble JS. Changes in membrane potential during the progression of MCF-7 human mammary tumor cells through the cell cycle. J Cell Physiol 1995; 165: 177 – 85. 2 Wonderlin WF, Strobl JS. 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Publication Year: 2004
Publication Date: 2004-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 64
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