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[147], 'American': [150, 3116], 'Heart': [151, 3117, 3155, 3574], 'Association': [152], 'included': [153], 'a': [154, 180, 186, 265, 461, 467, 723, 742, 787, 830, 922, 1209, 1220, 1510, 1685, 1702, 1836, 2074, 2329, 2408, 2464, 2506, 2562, 2624, 2872, 2976, 3432, 3460, 3525, 3690, 3914], 'debate': [155, 2371], 'on': [156, 200, 412, 427, 454, 573, 584, 875, 888, 901, 1180, 1500, 1593, 1661, 1779, 1925, 2021, 2031, 2119, 2153, 2171, 2179, 2186, 2193, 2204, 2245, 2251, 2289, 2292, 2297, 2328, 2551, 2719, 3317, 3423, 3500, 3628, 3728], 'proposition': [158], 'that': [159, 184, 223, 370, 457, 604, 1016, 1029, 1084, 1426, 1462, 1549, 1583, 1939, 1953, 2111, 2268, 2335, 2355, 2388, 2422, 2524, 2635, 2685, 2710, 2893, 2904], '"aortic': [160], 'diameter,': [161], 'aortic': [162, 192, 201, 587, 768, 775, 806, 820, 834, 845, 902, 926, 940, 945, 962, 966, 1099, 1174, 1197, 1291, 1344, 1350, 1588, 1662, 1669, 1676, 1713, 1812, 1876, 1915, 1954, 1958, 2064, 2104, 2154, 2180, 2194, 2390, 2429, 2499, 2512, 2542, 2781, 2843, 3054, 3545, 3569, 3600, 3629, 3635, 3652, 3729, 3880, 3922, 4059, 4188, 4230], 'stiffness,': [163, 2195], 'wave': [165, 195, 204, 241, 373, 664, 690, 770, 1352, 1357, 1362, 1389, 1396, 1506, 1522, 1531, 1547, 1609, 1664, 1792, 2032, 2205, 2218, 2226, 2246, 2279, 2298, 2578, 2602, 2618, 2653, 2697, 2810, 3143, 3319, 3873], 'reflection': [166, 196, 205, 242, 1523, 1793, 2033, 2206, 2280, 2299, 2619, 3144, 3320], 'all': [167, 1173, 2980], 'increase': [168, 611, 670, 685, 832, 857, 1348, 1355, 1387, 1597, 1625, 1726, 1961], 'with': [169, 206, 352, 389, 434, 441, 512, 644, 686, 716, 757, 784, 793, 808, 837, 858, 935, 947, 950, 968, 990, 1053, 1176, 1208, 1285, 1391, 1407, 1491, 1541, 1715, 1917, 1964, 1985, 2050, 2066, 2071, 2085, 2342, 2366, 2403, 2511, 2517, 2620, 2640, 2658, 2676, 2758, 2772, 2883, 2908, 3058, 3092, 3145, 3342, 3733], 'age': [170, 624, 645, 687, 717, 727, 739, 746, 785, 809, 948, 991, 1089, 1177, 1716, 1918, 1965, 2072, 2140, 2379, 2641, 3147, 3499], 'in': [172, 191, 233, 275, 289, 296, 340, 359, 366, 386, 396, 481, 498, 519, 541, 549, 555, 600, 680, 688, 712, 718, 767, 786, 798, 805, 822, 833, 861, 882, 928, 933, 964, 983, 992, 996, 1073, 1078, 1086, 1090, 1108, 1205, 1214, 1240, 1314, 1326, 1339, 1349, 1356, 1378, 1383, 1388, 1404, 1424, 1436, 1445, 1459, 1477, 1514, 1535, 1561, 1565, 1598, 1684, 1701, 1727, 1771, 1785, 1797, 1897, 2161, 2237, 2263, 2278, 2283, 2401, 2515, 2561, 2587, 2594, 2623, 2642, 2646, 2655, 2674, 2682, 2728, 2745, 2806, 2824, 2845, 2900, 2951, 3021, 3056, 3087, 3139, 3148, 3277, 3321, 3382, 3431, 3452, 3548, 3661, 3697, 3731, 3762, 3830, 3850, 3936, 3944, 3958, 3972, 4012, 4081, 4118, 4229, 4236], 'isolated': [173, 209, 2089, 2404, 3346], 'systolic': [174, 210, 355, 539, 559, 565, 598, 607, 626, 714, 749, 1428, 1469, 1475, 1493, 1768, 1868, 1944, 1955, 2040, 2048, 2090, 2213, 2405, 2743, 3059, 3094, 3347, 3396, 4036], 'hypertension."': [175], 'This': [176, 1449, 1880, 2875], 'was': [177, 311, 458, 517, 551, 1433, 1450, 1623, 2453, 2547, 2834, 2849, 2859], 'stimulated': [178], 'by': [179, 327, 338, 405, 460, 524, 553, 568, 612, 627, 632, 847, 955, 1411, 1452, 1509, 1518, 1832, 1849, 1904, 2216, 2378, 2381, 2439, 2549, 2854, 4191], 'series': [181], 'articles1–5': [183], 'took': [185], 'contrary': [187], 'position': [188], 'change': [190, 310, 548, 554, 637, 898, 1403, 1916, 2070, 2375], 'diameter': [193, 807, 846, 1857, 2430, 2500, 2510, 2543], 'placed': [198], 'emphasis': [199], 'stiffness': [202, 1341, 1599, 1714, 2155, 3055, 3141], 'over': [203, 226, 437, 1472, 1633, 2372], 'aging': [207, 252, 547, 1011, 1660, 1950, 3422, 3458, 3527, 3727], 'hypertension.': [211, 2406, 3060, 3095, 3322, 3831, 3959, 3973, 4083], 'purpose': [213], 'review': [216], 'is': [217, 229, 246, 294, 374, 466, 638, 659, 667, 683, 700, 736, 810, 885, 1032, 1043, 1076, 1200, 1238, 1250, 1259, 1507, 1551, 1935, 1967, 2035, 2042, 2107, 2223, 2235, 2281, 2309, 2332, 2352, 2370, 2376, 2399, 2424, 2558, 2917, 2944, 3689], 'summarize': [219], 'conventional': [221, 1940, 2967], 'view': [222, 2409], 'has': [224, 269, 1893, 2099, 2156, 2672], 'evolved': [225], 'decades6–12': [227], 'but': [228, 854, 949, 974, 2144, 2368, 2505], 'not': [230, 975, 1251, 1894, 2147, 2230, 2271, 2667, 2945, 3827], 'precisely': [231], 'argued': [232], 'literature.': [235], 'According': [236], 'view,': [239], 'early': [240, 521, 1088, 1384, 1474, 1486, 1519, 1608, 1767, 2217], 'from': [243, 313, 323, 423, 651, 726, 999, 1270, 1363, 1397, 1463, 1737, 1826, 1854, 2001, 2008, 2102, 2302, 2413, 2443, 2604, 2783, 2809, 2975], 'peripheral': [244, 1267, 1365, 2187, 2265, 2293, 2345], 'arteries': [245, 550, 695, 1269, 2340, 2347], 'dominant': [248], 'ill': [249, 1585], 'effect': [250, 1622, 2118, 2152, 2178, 2185, 2222, 2242, 2288, 2308, 2452, 2466, 2616], 'logical': [256, 2076], 'target': [257], 'for': [258, 491, 590, 1113, 1931, 1975, 2055, 2132, 2138, 2159, 2318, 2324, 2420, 2457, 2490, 2664, 2838, 3352, 3463, 4106, 4115], 'therapy.12–14Observations': [259], 'Measurements"Premature': [261], 'arterial': [262, 336, 391, 417, 556, 642, 1571, 1738, 2013, 2069, 2199, 2255, 2382, 3107, 3140, 3425, 3853, 3946, 3970, 4079, 4156], 'senility"': [263], 'as': [264, 285, 393, 395, 489, 661, 1081, 1223, 1318, 1409, 1578, 1901, 1987, 1989, 2028, 2030, 2088, 3875, 3913], 'cardiovascular': [266, 2866, 3453], 'risk': [267, 535], 'factor': [268], 'long': [270, 442], 'been': [271, 288, 528, 1895, 2100, 2128, 2148, 2157, 2316, 2469, 2668], 'intense': [273], 'interest': [274], 'actuarial': [276], 'studies,': [277, 1900, 2449], 'even': [278, 1533], 'before': [279], 'introduction': [280], 'cuff': [283, 515], 'sphygmomanometer,6': [284], 'it': [286, 2106, 2228], 'had': [287, 527], 'clinical': [290, 1556, 1899, 3240, 4027, 4082], 'medicine.': [291], 'latter': [293, 1331], 'apparent': [295, 2232], 'textbooks': [298, 1080], 'Osler': [300, 3178], 'Mackenzie': [302, 3195], '>100': [303], 'years': [304, 622, 729, 1246, 1465], 'ago.7,8': [305], 'In': [306, 1495, 1526, 2165, 2445, 2787], 'these,': [307], 'premature': [308, 416], 'arteriosclerotic': [309], 'assessed': [312], 'pulse': [315, 337, 383, 561, 609, 630, 663, 689, 769, 977, 1351, 1405, 1432, 1946, 1959, 2019, 2433, 2503, 2513, 2536, 2577, 2601, 3050, 3085, 3318, 3399, 3687, 4157], 'waveform': [316, 384, 1406, 1830, 1844, 2765, 2782, 4190], 'palpated': [317], 'at': [318, 738, 752, 781, 2572], 'wrist': [320], 'or': [321, 1488, 1824, 1852, 1870, 2006, 2291, 2380, 2485, 2891, 3398], 'measured': [322, 660, 751, 1796, 1819, 2236, 2392, 2580, 2585], 'radial': [325, 439, 493, 1440, 1828, 2785, 4195], 'artery': [326, 780, 1441, 2902, 3822, 3911], 'sphygmography.': [328], 'first': [330], 'graphic': [331], 'recording': [332], 'studies': [333, 583, 827, 843, 905, 932, 959, 1008, 1557, 1560, 2170], 'Marey': [339, 3220], '18639': [341], 'noted': [342, 2523, 2768, 2803], 'characteristic': [343, 1605, 1728, 2181, 2927, 2939], 'differences': [344, 871, 2663], 'between': [345, 534, 576, 618, 671, 704, 773, 915, 2428, 2498, 2862], 'young': [346, 483, 1686, 1703, 1773], 'old': [348, 500, 504, 1689, 1707], 'persons': [349, 388, 2402], '(Figure': [350, 634, 677, 839, 1524, 1618, 1878, 1937, 2726], '1),': [351], 'prominent': [353], 'late': [354, 1379, 1427, 1468, 1515, 1747, 2047, 2212], 'augmentation': [356, 1429, 1800, 1861, 2009, 2214, 2637, 2665, 2675, 2826, 2847, 2863, 2921, 2934, 3918, 4113], '("tidal': [357], 'wave")': [358], 'latter.': [361], 'Mahomed10,11': [362], 'confirmed': [363, 1451, 1558], 'these': [364, 401, 1189, 2448, 2716], 'changes': [365, 385, 1175, 1971, 3381, 3758, 3849, 4228], '1870s,': [368], 'stressing': [369], '"the': [371], 'tidal': [372], 'prolonged': [375], 'too': [377, 2919, 2932], 'much': [378], 'sustained,"': [379], 'noting': [381, 2622], 'similar': [382, 1082, 2314, 2435], 'asymptomatic': [387, 542], 'elevated': [390, 3084], 'pressure': [392, 540, 566, 588, 599, 610, 631, 715, 897, 1152, 1324, 1377, 1505, 1513, 1546, 1663, 1677, 1723, 1742, 1769, 1784, 1809, 1829, 1947, 1960, 2014, 2234, 2451, 2504, 2514, 2568, 2586, 2694, 2764, 2844, 3051, 3086, 3397, 3688, 3872, 4017, 4189], 'well': [394, 1988, 2029], 'elderly.': [398], 'By': [399], '1900,': [400], 'findings': [402, 2436], 'were': [403, 2437, 2482, 2679], 'used': [404, 2323], 'life': [406, 1027, 1212], 'insurance': [407], 'companies': [408], 'decline': [410], 'applicants': [411], 'basis': [414, 877, 1595, 2253], 'senility.6Download': [418], 'figureDownload': [419, 708, 763, 979, 1655], 'PowerPointFigure': [420, 709, 764, 980, 1656], '1.': [421], 'Tracings': [422], "Marey's": [424], 'original': [425, 432], 'publication': [426], 'sphygmogram.9': [429], 'Top,': [430], 'instrument,': [433], 'base-plate': [435], 'applied': [436, 1224], 'artery,': [440, 2590], 'stylus,': [443], 'pivoting': [444], 'near': [445], 'site': [447, 2489, 2575, 2705], 'recording,': [449], 'drawing': [450], 'an': [451, 668, 1087, 2425, 2525, 3602, 3876], 'amplified': [452], 'signal': [453], 'smoked': [455], 'paper': [456], 'moved': [459], 'wind-up,': [462], 'clockwork': [463], 'mechanism.': [464], 'Inset': [465], '"square': [468], 'wave"': [469], 'test': [470], 'establish': [472], 'frequency': [473, 1635, 1700, 1884], 'response': [474, 1885], 'instrumental': [476], 'artifact.': [477], 'Center,': [478], 'Sphygmograph': [479, 496], 'tracings': [480, 497], '2': [482], 'adults,': [484], 'showing': [485, 507], 'patterns': [486, 509, 3378], 'still': [487, 855, 1444], 'regarded': [488], 'typical': [490, 508], 'artery.': [494, 1329, 1448], 'Bottom,': [495], '4': [499, 1639], 'men': [501, 993, 3150, 3350], '(left)': [502, 994, 1687], 'women': [505, 997], '(right),': [506, 998], 'senescence': [511], 'accompanying': [513, 899], 'arteriosclerosis.The': [514], 'sphygmomanometer': [516], 'introduced': [518], '1900s,': [522], '1916,': [525], 'data': [526, 2296, 2974], 'presented': [529], 'show': [531, 603], 'relationship': [533, 1338, 2427, 2508, 2861, 4015], 'death': [537], 'persons.6': [543], 'For': [544], 'decades': [545], 'thereafter,': [546], 'gauged': [552], 'pressure,': [557, 750, 3395], 'especially': [558, 1957], 'pressure.15,16': [562], 'But': [563], 'brachial': [564, 713, 976, 1438, 1943, 2432, 2502], 'increases': [567, 755], 'only': [569, 2559], '≈25': [570], 'mm': [571, 616, 1154], 'Hg': [572, 617], 'average': [574, 2829], '(≈22%)': [575], 'ages': [577, 672], '20': [578, 619, 673], '80': [580, 621, 675, 2832], 'years.': [581], 'Recent': [582], 'central': [585, 605, 973, 1482, 1803, 2012, 2606, 4187], 'allow': [589], 'normally': [592, 1289, 1642], 'high': [593, 2925, 3734], 'amplification': [594], 'upper': [596, 2239], 'limb': [597, 1782], 'youth': [601], '(aortic)': [606], '35': [613], '40': [615, 1245], '(ie,': [625], '≈40%': [628], '>100%12,17': [633], '2).': [635, 1759], 'Such': [636, 1070, 1354, 1386, 1970, 2124, 2276, 2407, 2463, 2660], 'generally': [639], 'attributed': [640], 'stiffening': [643, 658, 1281, 1589], 'return': [647, 1368, 1520, 1733, 2272], 'reflected': [649, 1361, 1395, 1530, 1735, 2261, 2696, 2913], 'waves': [650, 1678, 1682, 1736, 2262], 'periphery': [653], 'heart.12': [656], 'When': [657, 1293], '"aortic"': [662], 'velocity,': [665, 1390], 'there': [666, 682, 1550, 2369, 2423, 2858], '≈100%': [669], 'years18': [676], '3).': [678], 'However,': [679, 2313], 'contrast,': [681], 'little': [684, 702], 'velocity': [691, 771, 1358, 2579, 2593, 2603], 'within': [692, 1195, 1244, 1253, 2628], 'muscular': [693, 1268, 2188, 2346], 'conduit': [694], 'limbs.5,18,19': [698], 'There': [699, 884, 1042, 2351, 2678], 'also': [701, 1457], 'difference': [703], 'males': [705], 'females.5,18,19Download': [707], '2.': [710], 'Change': [711], 'multiple': [719, 2552], 'population': [720, 2627], 'studies70–74': [721], 'shows': [722, 1675, 1693], 'steep': [724], 'rise': [725, 744], '5': [728, 2816], 'plateau': [731], 'when': [732, 1257, 1323, 2037, 2233, 2776], 'full': [733], 'body': [734, 880, 2459], 'height': [735], 'reached': [737], '18,': [740], 'then': [741, 1306], 'subsequent': [743], 'after': [745, 1230, 2418, 2455], '45.': [747], 'cardiac': [753, 1822, 2092, 3448], 'catheterization,19': [754], 'progressively': [756, 815], 'age.': [758, 2659, 2677], 'After': [759, 1789], "O'Rourke.12Download": [762], '3.': [765], 'Changes': [766, 1104, 1996, 3138], '(PWV;': [772], 'root': [776, 3546, 3570, 3630], 'femoral': [779, 2610], 'groin)': [783], 'group': [788, 2481, 2631, 2798], '480': [790], 'human': [791, 1012, 2163, 3764, 3852], 'subjects': [792, 920, 1461, 3091], 'low': [794, 2284, 2937, 3736], 'prevalence': [795, 3633, 3737], 'atherosclerosis': [797], 'urban': [799, 3435], 'Beijing.': [800], 'Avolio': [802, 3408, 3487, 3707, 3751, 3841, 3866], 'et': [803, 1161, 1415, 1454, 1906, 1910, 2385, 2441, 2493, 2583, 2612, 2801], 'al.18Increase': [804], 'usually': [811, 1968], 'invoked': [812], 'explain': [814], 'increasing': [816, 2645], 'prominence': [817], 'knuckle': [821], 'routine': [823], 'chest': [824], 'radiographs.': [825], 'Autopsy': [826], 'have': [828, 851, 942, 960, 1014, 2114, 2127, 2146, 2174, 2201, 2300, 2468, 2567, 2666, 2687, 2712, 2755, 2767, 2778, 2870], 'shown': [829, 852, 943, 961, 1015, 2175], 'clear-cut': [831], 'surface': [835, 984], 'area': [836, 985, 4231], 'age20': [838], '4),': [840], 'whereas': [841, 1484, 2344, 2648, 2868], 'cross-sectional': [842], 'angiography21': [848], 'ultrasound22–26': [850], 'lesser,': [853], 'definite,': [856], 'age,': [859, 893, 900, 1408, 2086, 2343, 2367, 2421, 2458, 2621], 'except': [860], 'proximal': [864, 1242, 1602, 1712, 2339, 2362, 3053], 'part': [865], 'ascending': [868, 3694, 3879, 3921], 'aorta.': [869, 2123, 3766], 'Gender': [870], 'largely': [873, 1973], 'explicable': [874], 'smaller': [879], 'size': [881, 3631], 'women.12,19': [883], 'some': [886, 1231, 1898, 2411], 'controversy': [887], 'competing': [890], 'effects': [891, 1586, 1924, 2126, 2145, 2203, 2315], 'blood': [896, 2591, 3383], 'dilation.': [903], 'Cross-sectional': [904, 958], 'cannot': [906], 'be': [907, 1095, 1591, 1818, 1846, 1998, 2053, 2231, 2249, 2733, 2906, 2923, 2936, 2964], 'expected': [908, 1252], 'resolve': [910], 'issue.': [912], 'A': [913, 3164, 4026], 'comparison': [914, 4159], 'hypertensive': [916], 'matched': [918], 'normotensive': [919], 'showed': [921, 1458, 1582], 'greater': [923, 1435, 1443, 2701, 2770], 'degree': [924], 'dilation': [927, 946, 953, 963, 1279, 2256, 3547], 'latter.26': [930], 'Longitudinal': [931], 'patients': [934, 2516, 3057], 'Marfan': [936, 969, 1091, 2518, 3550, 3698], 'syndrome': [937, 970, 1092], 'cystic': [939, 965, 1067], 'necrosis': [941, 967, 1072], 'progressive': [944, 1058], 'rate': [951, 4117], 'decreased': [954, 2036, 2639], 'antihypertensive': [956], 'therapy.27': [957], 'related': [971, 2470, 2736], 'pressure.28Download': [978], '4.': [981], 'thoracic': [988, 2363, 3765], 'aorta': [989, 1243, 1284, 1603, 2337, 2364, 2528, 2607, 3695], 'unselected': [1001], 'autopsy': [1002], 'study': [1003, 2480, 2841, 4028], 'Mitchell': [1005, 2384, 2582, 2730, 2955, 3005, 3030, 3066, 3101, 3122, 3471], 'Schwartz.20Pathological': [1007], 'aorta29,30': [1013], 'thickness': [1017], 'load': [1020, 3430], 'bearing': [1021], 'media': [1022, 1062], 'remains': [1023, 2983], 'relatively': [1024], 'constant': [1025], 'throughout': [1026], 'wall': [1030, 1133, 1298, 1345], 'thickening': [1031], 'attributable': [1033], 'predominantly': [1034], 'increased': [1036, 1718, 2654], 'width': [1037], 'intimal': [1040], 'layer.': [1041], 'thinning,': [1044], 'fraying,': [1045], 'fracture': [1047, 1187, 1229], 'elastin': [1050, 1139, 1193, 1275, 3760], 'fibers,': [1051], 'together': [1052], 'collagenous': [1054, 1312], 'remodeling': [1055], '(Table),': [1056], 'disorganization': [1059], 'with,': [1063], 'ultimate': [1064], 'development': [1065, 1976], 'medial': [1068, 1071, 1146], 'necrosis.': [1069], 'elderly': [1075, 4119], 'described': [1077, 1410, 2101, 2131, 2317], 'pathology': [1079], 'seen': [1085], 'substrate': [1097], 'dissection,': [1100], 'dilation,': [1101], 'rupture.31,32Age-Related': [1103], 'Elastin': [1106, 1199, 1287], 'Lamellae': [1107], 'Human': [1110], 'Mid-Thoracic': [1111], 'Aorta': [1112], 'Young': [1114, 3190, 3215], '(18–40': [1115], 'years)': [1116, 1120], 'Old': [1118], '(56–58': [1119], 'Persons': [1121], 'who': [1122, 1456], 'Died': [1123], 'Noncardiovascular': [1125], 'DiseaseMeasurementYoungOldChange': [1126], '%PMeanSEMeanSED': [1127], 'indicates,': [1128], 'pressure-fixed': [1129], 'external': [1130], 'diameter;': [1131], 'WT,': [1132], 'thickness;': [1134, 1147], 'ILS,': [1135], 'interlaminar': [1136], 'spacing;': [1137], 'EFD,': [1138], 'fiber': [1140], 'density': [1141], '(lamellar': [1142], 'units/': [1143], 'mm);': [1144], 'MT,': [1145], 'T/LU,': [1148], 'calculated': [1149, 2063, 2825, 2924, 4063], '(at': [1150, 1704, 1709], 'mean': [1151], '100': [1153], 'Hg)': [1155], 'tension': [1156], 'per': [1157], 'lamellar': [1158], 'unit.*From': [1159], 'al.30D': [1162], '(mm)17.01.122.40.731.8<0.01WT': [1163], '(mm)0.940.011.400.0349.1<0.001ILS': [1164], '(μm)8.71.112.00.937.8<0.05EFD': [1165], '(LU/mm)12515366−71.2<0.05MT': [1166], '(μm)0.790.011.000.0226.4<0.001T/LU': [1167], '(dyne/cm21236162189110753.0<0.01Interpretations': [1168], 'ExplanationsConventional': [1170], 'explanations': [1171], 'based': [1179], 'physical': [1182], 'principles': [1183, 1218], 'fatigue': [1185], 'because': [1188, 2306], 'affect': [1190], 'inert': [1192, 1203], 'fibers': [1194, 1276, 1288], 'media.12': [1198], 'substance': [1204], 'body,': [1207], 'chemical': [1210], 'half': [1211, 2835], 'measurable': [1213], 'decades.': [1215], 'same': [1217, 2574], 'material': [1221], 'fatigue,': [1222], 'natural': [1226], 'rubber,': [1227], 'predict': [1228], '109': [1232], 'cycles': [1233], '8%': [1235], 'stretch,': [1236], 'which': [1237, 1261, 1611, 1641, 1872, 2416, 2846, 2884], 'achieved': [1239, 1896], 'life.': [1248], 'Fracture': [1249], 'time': [1255, 2808], 'span,': [1256], 'stretch': [1258], '<5%,': [1260], 'explains': [1262, 1278, 1333, 1401], 'relative': [1263, 2057], 'immunity': [1264], 'process.5,18,33Fracture': [1272], 'readily': [1277, 1795], 'age.12': [1286], 'bear': [1290], 'stresses.': [1292], 'they': [1294, 2269], 'give': [1295], 'way,': [1296], 'stretches': [1299], 'vessel': [1302], 'dilates;': [1303], 'stresses': [1304, 1319], 'transferred': [1307, 1322], 'less': [1310, 2349], 'extensible': [1311], 'elements': [1313], 'wall,': [1316], 'just': [1317], 'so': [1321, 1548, 2267], 'rises': [1325], 'normal': [1328, 1460, 3526, 3941, 4013], 'phenomenon': [1332], 'well-known': [1335], 'nonlinear': [1336], 'pressure/diameter': [1337], 'arteries.Increased': [1340], 'causes': [1346, 1359, 1717, 1740], 'corresponding': [1347, 2821], 'velocity.': [1353], 'arterioles': [1366, 2290], 'earlier': [1369, 1534, 1559], 'heart': [1372, 3023, 4116], 'boost': [1375], '(augment)': [1376], 'systole': [1380, 1516, 1536, 1748], 'rather': [1381], 'than': [1382, 1439, 1966, 2474, 2707, 2775], 'diastole.12': [1385], 'movement': [1392], 'diastole': [1398], 'into': [1399, 1746, 4077], 'systole,': [1400], 'Marey,': [1412], 'Mackenzie,': [1413], 'Mahomed': [1414, 1421, 3235, 3252], 'al,': [1416], 'referred': [1418], 'above.': [1420], 'pointed': [1422], 'out': [1423], '1872': [1425], 'always': [1434], 'carotid': [1447, 1479, 1843, 1856, 2589, 2636, 2747, 2763, 3871, 3910, 4112], 'Kelly': [1453, 3837, 3860], 'al,34': [1455], '30': [1464], 'onward,': [1466], 'peak': [1470, 1476, 1487, 1492, 1724, 1743, 1761, 1770, 1875, 2897], 'dominates': [1471], 'other': [1481, 2198, 2321, 2680], 'arteries;35,36': [1483], 'shoulder': [1489, 1499, 2744, 2892], 'corresponds': [1490, 1764, 1873, 2894], 'flow.': [1494], 'older': [1496, 1787, 2162, 3090, 4237], 'subjects,': [1497], 'upstroke': [1502], 'followed': [1508], 'surge': [1511], 'caused': [1517, 2215], '5).': [1525, 1619, 1879, 2753], 'elderly,': [1528], 'arrives': [1532], 'merges': [1538], '(or': [1539, 1544, 2749], 'blends)': [1540], 'incident': [1543], 'forward)': [1545], 'no': [1552, 2176, 2333, 2353, 2496, 2860], 'inflection': [1553, 1778, 2724, 2750, 2813, 2889], 'point.12,21': [1554], 'These': [1555, 1573], 'experimental': [1562, 2169], 'animals': [1563], 'computer': [1566], 'models': [1567], 'systemic': [1570, 3938, 3993], 'tree.37–40': [1572], 'expressed': [1574], 'pulsatile': [1575, 2532, 3933], 'pressure/flow': [1576], 'relationships': [1577], 'vascular': [1579, 2004, 3464], 'impedance': [1580, 1613, 1628, 1670, 1694, 1729, 1751, 2005, 2928, 2940, 3990, 4011], 'could': [1590], 'explained': [1592, 2250], '(increased': [1604], 'impedance)': [1606], 'reflection,': [1610, 2227], 'shifted': [1612], 'curves': [1614], 'higher': [1616, 2531, 2535], 'frequencies12,37–41': [1617], 'combined': [1621], 'markedly': [1626], 'left': [1630, 1649, 1807, 1814, 1926, 1978, 1982, 2025, 2038, 2596, 3428, 4034], 'ventricular': [1631, 1650, 1815, 1927, 1979, 1983, 2026, 2039, 2597, 3429, 4035], 'ejection': [1632, 1651, 2027, 2049], 'band': [1636], '(1': [1637], 'Hz),': [1640], 'contains': [1643], 'greatest': [1645], 'energy': [1646, 3934], '(flow)': [1652], 'wave.': [1653], 'Download': [1654], '5.': [1657], 'Effects': [1658, 3310, 3420, 3497], 'contour': [1665], '(time': [1666], 'domain)': [1667], 'modulus': [1671, 1695], '(frequency': [1672], 'domain).': [1673], 'Top': [1674], '(above)': [1679], 'flow': [1681, 1763, 2533, 2570, 2592, 2899], '(below)': [1683], '(right)': [1690], 'adult.': [1691], 'Bottom': [1692], '(vertical': [1696], 'axis)': [1697], 'plotted': [1698], 'against': [1699], 'left)': [1705], 'subject': [1708, 1774], 'right).': [1710], 'Increased': [1711], 'amplitude': [1719, 2649], 'initial': [1722, 2742], '(arrow': [1730, 1758], '1).': [1731], 'Earlier': [1732], 'terminations': [1739], 'move': [1745], 'curve': [1752], 'shift': [1754], 'right': [1757], 'rising': [1781], 'subject.': [1788], "O'Rourke.39ImplicationsEffects": [1790], 'terms': [1798], '(carotid,': [1804], 'aortic,': [1805], 'ventricular)': [1808], 'waveform.': [1810], 'waveforms': [1816, 2774], 'may': [1817, 1845, 2052, 2229, 2467, 2732, 2905], 'invasively': [1820], 'during': [1821], 'catheterization41–43': [1823], 'synthesized': [1825, 2779], 'recorded': [1831, 1847], 'applanation': [1833, 1850, 4161], 'tonometry': [1834, 3912, 4162, 4196], 'using': [1835, 2394], 'Food': [1837], 'Drug': [1839], 'Administration–approved': [1840], 'process.12,44': [1841], 'directly': [1848], 'tonometry1–5,34–36,44,45': [1851], 'approximated': [1853], 'waveform.46': [1858], 'Measurement': [1859], 'requires': [1862, 1881], 'identification': [1863], 'localized': [1866], 'peak,': [1867], 'shoulder,': [1869], 'inflection,': [1871], 'flow34,41': [1877], 'accurate': [1882], 'dynamic': [1883], 'sensor,': [1887], 'recorder,': [1888], 'convolutional': [1890], 'process': [1891], 'discussed': [1902, 2969], 'specifically': [1903], 'Chen': [1905, 3410, 3890, 4171], 'al47': [1907], 'Smulyan': [1909, 4046], 'al.43The': [1911], 'principal': [1912], 'implications': [1913], 'relate': [1919], 'their': [1921, 1923, 2839], 'magnitude,': [1922], 'function,': [1928], 'opportunities': [1930], 'therapeutic': [1932], 'modification.': [1933], 'It': [1934, 2943], 'clear': [1936], '2)': [1938], 'measurements': [1941, 2002, 2717], 'underestimate': [1948], 'effect,': [1951], 'far': [1962, 2769], 'more': [1963, 2075, 2357], 'perceived.12,16,17': [1969], 'responsible': [1974, 2054], 'hypertrophy': [1980], 'dysfunction': [1984], 'age48': [1986], 'renal': [1990], 'dysfunction49,50': [1991], 'progression': [1993], 'atherosclerosis.51': [1995], 'can': [1997, 2208, 2248, 2886, 2963], 'best': [1999], 'quantified': [2000], 'inferred': [2007], 'pulse.': [2015, 3854], 'Augmentation': [2016], 'depends': [2020], 'pattern': [2023], 'function': [2041], 'impaired.52': [2043], 'Inability': [2044], 'maintain': [2046], 'age12,21': [2051], 'flattening': [2058], 'carotid34': [2060], 'augmentation53': [2065], 'age.Knowledge': [2067], 'permits': [2073], 'approach': [2077], 'drug': [2079], 'therapy': [2080, 2472], 'diseases': [2083], 'associated': [2084, 3341], 'such': [2087, 2773, 2949], 'hypertension,': [2091], 'failure,': [2093], 'angina': [2095], 'pectoris.': [2096], 'what': [2098], 'pathological': [2103], 'change,': [2105], 'difficult': [2108], 'envisage': [2110], 'drugs': [2112, 2322], 'would': [2113], 'any': [2115, 2287, 2450], 'major': [2116, 3450, 3691], 'direct': [2117, 2151, 2177], 'disorganized': [2121], 'aged': [2122], 'beneficial': [2125], 'sought': [2129], 'vasopeptidase': [2134], 'inhibitor': [2135], 'omapatrilat2': [2136], 'cross-link': [2141], 'breaker': [2142], 'AT711,54': [2143], 'substantial.': [2149], 'No': [2150], 'found': [2158, 2495, 2871], 'nitrates': [2160, 2173, 2196, 2244, 2305], 'adults.55–57': [2164], 'very': [2166], 'carefully': [2167], 'controlled': [2168], 'animals,': [2172], 'impedance,': [2182], 'despite': [2183], 'marked': [2184, 2202], 'arteries.58In': [2189], 'contrast': [2190], 'inefficacy': [2192], 'dilators': [2200], 'virtually': [2209], 'eliminate': [2210], 'reflection.56,59': [2219], 'Because': [2220], 'confined': [2224], 'limb.60,61': [2240], 'Beneficial': [2241], 'reflection14,56': [2247], '"trapping"': [2259], 'vessels': [2266], 'do': [2270], 'heart.': [2275], 'reduction': [2277], 'achievable': [2282], 'dosage': [2285], 'without': [2286], 'resistance.56,59': [2294], 'Most': [2295], 'come': [2301], 'use': [2303, 3241], 'immediate': [2310], 'dramatic.': [2312], 'perindopril': [2319], 'treatment': [2325], 'hypertension.13,62Reservations': [2327], 'Contrary': [2330], 'ViewThere': [2331], 'argument': [2334, 2354], 'stiffen': [2341], 'affected.5,18,19': [2350], 'distal': [2358], 'segments': [2359], 'dilate': [2365], 'whether': [2373], 'induced': [2377], 'pressure.': [2383, 2491, 2537, 3384, 3400, 3881, 3923, 4037], 'al3,63': [2386], 'argue': [2387], '"effective': [2389], 'diameter"': [2391], 'indirectly': [2393], 'water': [2396, 2555], 'hammer': [2397, 2556], 'equation': [2398], 'reduced': [2400, 2708, 3829, 4235], 'gains': [2410], 'support': [2412], 'Framingham': [2414, 2521, 2630, 3154, 3573], 'data,24': [2415], 'showed,': [2417], 'correction': [2419, 2456], 'inverse': [2426], 'pressure;': [2434], 'reported': [2438, 2669, 2853], 'Agmon': [2440, 2479, 3581], 'al': [2442], 'Mayo.25': [2444], 'both': [2446, 2656], 'trivial': [2454], 'size,': [2460], 'gender.': [2462], 'pressure-related': [2465], '(more': [2473], 'one': [2475, 2885], 'third': [2476], 'receiving': [2483], 'antihypertensives)': [2484], 'measuring': [2488], 'Jondeau': [2492, 3672], 'al28': [2494], 'association': [2497], 'definite': [2507], 'syndrome.': [2519, 3551, 3663, 3699], 'group24': [2522], 'initially': [2526], 'narrow': [2527], 'predisposes': [2529], 'concept': [2539], 'effective': [2541], 'its': [2545], 'derivation': [2546], 'challenged': [2548], 'us64': [2550], 'grounds.': [2553], 'formula': [2557], 'valid': [2560], 'reflectionless': [2563], 'system': [2564], 'must': [2566], 'measure': [2571], 'locally.12,64': [2581], 'al3': [2584], 'outflow': [2598], 'tract,': [2599], 'artery.Mitchell': [2611], 'al5': [2613], 'downplayed': [2614], 'select': [2625], 'healthy': [2626, 3149], '(<20%': [2632], 'all)': [2634], 'index': [2638, 2848, 2864, 3919, 4114], 'women,': [2643], 'although': [2644], 'men,': [2647], 'forward': [2652, 2693], 'genders': [2657], 'discordant': [2661], 'gender': [2662], 'previously,': [2670], 'nor': [2671], 'decrease': [2673], 'anomalies': [2681], 'article': [2684], 'we': [2686, 2711, 2777], 'questioned,64–66': [2688], 'including': [2689], 'calculation': [2691], 'amplitude,': [2695], 'transit': [2698], 'time,': [2699], 'distance': [2702, 2709], 'reflecting': [2704], '(rather': [2706], 'described).12,21': [2713], 'All': [2714], 'depend': [2718], 'correct': [2720], 'determination': [2721, 3846], 'point34,41': [2725], '5).Anomalies': [2727], 'articles': [2731], 'methodological': [2734], 'detection': [2739], 'tracing': [2748], 'point;': [2751], 'Figure': [2752], 'We': [2754], 'experienced': [2756, 2797], 'problems': [2757, 2950, 2960], 'our': [2759], 'processing': [2760], 'variability': [2771], 'wave.67': [2786], 'second': [2789, 4031], 'Australian': [2790], '(ANBP2)': [2794], 'study,': [2795], 'Cameron': [2800, 4092], 'al45': [2802], 'wide': [2804, 2822], 'variation': [2805, 2823], 'foot': [2811, 2910], 'point': [2814, 2890], '300': [2818], 'ms': [2819, 2833], 'index.': [2827], 'Their': [2828], 'value': [2830, 2837], 'invasive': [2840], 'unusually': [2850], 'low.68': [2851], 'As': [2852], 'ANBP2': [2856, 4108], 'group,': [2857], 'events,': [2867], 'others69': [2869], 'positive': [2873], 'association.': [2874], 'important': [2876], 'issue': [2877], 'comes': [2878], 'down': [2879], 'accuracy': [2882], 'identify': [2887], 'blended': [2907], 'wave.12,21': [2914], 'If': [2915], 'identified': [2918, 2931], 'early,': [2920], 'will': [2922, 2935], 'low;': [2929], 'if': [2930], 'late,': [2933], 'falsely': [2941], 'high.': [2942], 'possible': [2946], 'exclude': [2948], 'interpretation': [2952], 'data.Until': [2956], 'unless': [2958], 'raised': [2961], 'above': [2962], 'excluded,': [2965], 'approach,': [2968], 'here': [2970], '(with': [2971], 'mutually': [2972], 'supportive': [2973], 'variety': [2977], 'sources,': [2979], 'logically': [2981], 'explicable)': [2982], 'strong.FootnotesCorrespondence': [2984], 'M.': [2986], "O'Rourke,": [2987], 'Suite': [2988], '810,': [2989], 'St.': [2990], 'Clinic,': [2992], '438': [2993], 'Victoria': [2994], 'St,': [2995], 'Darlinghurst,': [2996], 'NSW': [2997], '2010,': [2998], 'Australia.': [2999], 'E-mail': [3000], '[email': [3001], 'protected]': [3002], 'References': [3003], 'GF,': [3006, 3031, 3067, 3102, 3123], 'Tardif': [3007], 'JC,': [3008], 'Arnold': [3009], 'JMO,': [3010], 'Marchiori': [3011], 'G,': [3012, 3511, 3673], "O'Brien": [3013], 'TX,': [3014], 'Dunlap': [3015], 'ME,': [3016, 3289, 4147], 'Pfeffer': [3017, 3046, 3080], 'MA.': [3018, 3047, 3081], 'Pulsatile': [3019, 3969], 'hemodynamics': [3020, 3957, 4080], 'congestive': [3022], 'failure.': [3024], 'Hypertension.': [3025, 3157, 3323, 3637, 3832, 3924, 4068], '2001;': [3026, 4125, 4167], '38:': [3027], '1433–1439.CrossrefMedlineGoogle': [3028], 'Scholar2': [3029], 'Izzo': [3032, 3072, 3103], 'JL,': [3033, 3073], 'Lacourciere': [3034, 3068], 'Y,': [3035, 3069, 3582, 3812], 'Ouellet': [3036], 'JP,': [3037, 3071, 3683, 4002, 4006], 'Neutel': [3038, 3074], 'J,': [3039, 3075, 3513, 3643, 3816], 'Qian': [3040], 'C,': [3041, 3391, 3618], 'Kerwin': [3042, 3076], 'LJ,': [3043, 3077], 'Block': [3044, 3078], 'AJ,': [3045, 3079, 3592], 'Omapatrilat': [3048], 'reduces': [3049], 'Circulation.': [3061, 3096, 3358, 3385, 3437, 3466, 3529, 3576, 3700, 3855, 4019, 4203], '2002;': [3062, 4086], '105:': [3063], '2955–2961.LinkGoogle': [3064], 'Scholar3': [3065], 'Oellet': [3070], 'Determinants': [3082, 3566], 'middle-aged': [3088], 'uncomplicated': [3093], '2003;': [3097, 3324, 3467, 3609, 4069], '108:': [3098], '1592–1598.LinkGoogle': [3099], 'Scholar4': [3100], 'JL.': [3104], 'Evaluation': [3105], 'stiffness.': [3108], 'In:': [3109], 'Primer.': [3111], '3rd': [3112, 3781, 3795], 'ed.': [3113, 3187, 3280, 3796], 'Dallas,': [3114], 'Tex:': [3115], 'Association;': [3118], '2003:': [3119], '351–355.Google': [3120], 'Scholar5': [3121], 'Parise': [3124], 'H,': [3125, 4047], 'Benjamin': [3126], 'EJ,': [3127, 4133], 'Larson': [3128, 3369, 3562], 'MG,': [3129, 3370, 3563], 'Keyes': [3130], 'MJ,': [3131, 3535, 3616], 'Vita': [3132], 'JA,': [3133, 4141, 4143], 'Vasan': [3134, 3560], 'RS,': [3135, 3561], 'Levy': [3136, 3375, 3444, 3564], 'D.': [3137, 3376, 3445, 3565], 'advancing': [3146], 'women:': [3152], 'Study.': [3156, 3575], '2004;': [3158], '43:': [3159], '1239–1245.LinkGoogle': [3160], 'Scholar6': [3161], 'Postel-Vinay': [3162], 'N.': [3163], 'Century': [3165], 'Arterial': [3167, 3293, 3446, 3475, 3956], '1896–1996.': [3169], 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