Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2106090797', 'doi': 'https://doi.org/10.1073/pnas.051627098', 'title': 'Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis', 'display_name': 'Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis', 'publication_year': 2001, 'publication_date': '2001-02-13', 'ids': {'openalex': 'https://openalex.org/W2106090797', 'doi': 'https://doi.org/10.1073/pnas.051627098', 'mag': '2106090797', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11226230', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/30129'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.051627098', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc30129?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000990350', 'display_name': 'Jason E. Kokoszka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jason E. Kokoszka', 'raw_affiliation_strings': ['Center for Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067648589', 'display_name': 'Pınar Coşkun', 'orcid': 'https://orcid.org/0000-0002-8010-8403'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pinar Coskun', 'raw_affiliation_strings': ['Center for Molecular Medicine, Emory University School of Medicine,\r Atlanta, GA 30322'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine, Emory University School of Medicine,\r Atlanta, GA 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086980931', 'display_name': 'Luke Esposito', 'orcid': 'https://orcid.org/0000-0002-3565-9126'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Luke A. Esposito', 'raw_affiliation_strings': ['Center for Molecular Medicine, Emory University School of Medicine,\r Atlanta, GA 30322'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine, Emory University School of Medicine,\r Atlanta, GA 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085274471', 'display_name': 'Douglas C. Wallace', 'orcid': 'https://orcid.org/0000-0002-7480-8278'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Douglas C. Wallace', 'raw_affiliation_strings': ['Center for Molecular Medicine, Emory University School of Medicine,\r Atlanta, GA 30322'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine, Emory University School of Medicine,\r Atlanta, GA 30322', 'institution_ids': ['https://openalex.org/I150468666']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5085274471'], 'corresponding_institution_ids': ['https://openalex.org/I150468666'], 'apc_list': None, 'apc_paid': None, 'fwci': 10.213, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 478, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '98', 'issue': '5', 'first_page': '2278', 'last_page': '2283'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sod2', 'display_name': 'SOD2', 'score': 0.8431743}, {'id': 'https://openalex.org/keywords/mitochondrial-ros', 'display_name': 'Mitochondrial ROS', 'score': 0.49899793}, {'id': 'https://openalex.org/keywords/senescence', 'display_name': 'Senescence', 'score': 0.45020878}], 'concepts': [{'id': 'https://openalex.org/C2776108821', 'wikidata': 'https://www.wikidata.org/wiki/Q15335612', 'display_name': 'SOD2', 'level': 4, 'score': 0.8431743}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.763368}, {'id': 'https://openalex.org/C13591479', 'wikidata': 'https://www.wikidata.org/wiki/Q6881880', 'display_name': 'Mitochondrial permeability transition pore', 'level': 4, 'score': 0.7580439}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.7489642}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.62891144}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.6047133}, {'id': 'https://openalex.org/C57600042', 'wikidata': 'https://www.wikidata.org/wiki/Q227564', 'display_name': 'Oxidative phosphorylation', 'level': 2, 'score': 0.56360453}, {'id': 'https://openalex.org/C2778175917', 'wikidata': 'https://www.wikidata.org/wiki/Q17125553', 'display_name': 'Mitochondrial ROS', 'level': 3, 'score': 0.49899793}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.45698383}, {'id': 'https://openalex.org/C24586158', 'wikidata': 'https://www.wikidata.org/wiki/Q27075', 'display_name': 'Mitochondrial DNA', 'level': 3, 'score': 0.45488313}, {'id': 'https://openalex.org/C522857546', 'wikidata': 'https://www.wikidata.org/wiki/Q2070979', 'display_name': 'Senescence', 'level': 2, 'score': 0.45020878}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.37388453}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3420599}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.3228618}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32028753}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.31228688}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28673005}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0833388}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008930', 'descriptor_name': 'Mitochondria, Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006579', 'descriptor_name': 'Heterozygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008930', 'descriptor_name': 'Mitochondria, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008930', 'descriptor_name': 'Mitochondria, Liver', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008930', 'descriptor_name': 'Mitochondria, Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.051627098', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc30129', 'pdf_url': 'https://europepmc.org/articles/pmc30129?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30129', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11226230', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc30129', 'pdf_url': 'https://europepmc.org/articles/pmc30129?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1482769266', 'https://openalex.org/W1550007121', 'https://openalex.org/W1569716332', 'https://openalex.org/W1581717960', 'https://openalex.org/W1583208426', 'https://openalex.org/W1966429519', 'https://openalex.org/W1973620047', 'https://openalex.org/W1974396693', 'https://openalex.org/W2013866322', 'https://openalex.org/W2018185503', 'https://openalex.org/W2033817379', 'https://openalex.org/W2040215374', 'https://openalex.org/W2042138106', 'https://openalex.org/W2048339025', 'https://openalex.org/W2050454564', 'https://openalex.org/W2060363769', 'https://openalex.org/W2063385957', 'https://openalex.org/W2068337326', 'https://openalex.org/W2068568687', 'https://openalex.org/W2072978915', 'https://openalex.org/W2094655287', 'https://openalex.org/W2131452024', 'https://openalex.org/W2132826785', 'https://openalex.org/W2149967205', 'https://openalex.org/W2159479663', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W45625719', 'https://openalex.org/W3213027370', 'https://openalex.org/W3167753301', 'https://openalex.org/W2912849703', 'https://openalex.org/W2121393320', 'https://openalex.org/W2118491346', 'https://openalex.org/W2115424063', 'https://openalex.org/W2043587027', 'https://openalex.org/W2009116125', 'https://openalex.org/W1186303165'], 'abstract_inverted_index': {'To': [0], 'determine': [1], 'the': [2, 30, 58, 96, 105, 111, 119, 130, 136, 150, 155, 174, 184], 'importance': [3], 'of': [4, 57, 75, 80, 87, 104, 114, 158, 176, 183], 'mitochondrial': [5, 18, 31, 59, 88, 106, 133, 147, 164], 'reactive': [6, 165], 'oxygen': [7, 166], 'species': [8, 167], 'toxicity': [9], 'in': [10, 17, 22, 29, 48, 71, 95, 100, 141, 146, 149], 'aging': [11, 185], 'and': [12, 54, 82, 84, 110, 173], 'senescence,': [13], 'we': [14], 'analyzed': [15], 'changes': [16], 'function': [19, 148], 'with': [20, 24, 44, 67, 121, 125, 154], 'age': [21], 'mice': [23, 98], 'partial': [25, 69], 'or': [26], 'complete': [27, 46], 'deficiencies': [28], 'antioxidant': [32], 'enzyme': [33, 161], 'manganese': [34], 'superoxide': [35], 'dismutase': [36], '(MnSOD).': [37], 'Liver': [38], 'mitochondria': [39], 'from': [40, 64], 'homozygous': [41], 'mutant': [42], 'mice,': [43, 66], 'a': [45, 68], 'deficiency': [47, 70], 'MnSOD,': [49, 72], 'exhibited': [50], 'substantial': [51], 'respiration': [52], 'inhibition': [53, 79], 'marked': [55], 'sensitization': [56, 103], 'permeability': [60, 107], 'transition': [61, 108], 'pore.': [62], 'Mitochondria': [63], 'heterozygous': [65, 97], 'showed': [73], 'evidence': [74], 'increased': [76, 102], 'proton': [77], 'leak,': [78], 'respiration,': [81], 'early': [83], 'rapid': [85], 'accumulation': [86], 'oxidative': [89, 93, 159, 169], 'damage.': [90], 'Furthermore,': [91], 'chronic': [92], 'stress': [94], 'resulted': [99], 'an': [101], 'pore': [109], 'premature': [112, 144], 'induction': [113], 'apoptosis,': [115], 'which': [116], 'presumably': [117], 'eliminates': [118], 'cells': [120], 'damaged': [122], 'mitochondria.': [123], 'Mice': [124], 'normal': [126], 'MnSOD': [127], 'levels': [128], 'show': [129], 'same': [131], 'age-related': [132], 'decline': [134, 145], 'as': [135], 'heterozygotes': [137], 'but': [138], 'occurring': [139], 'later': [140], 'life.': [142], 'The': [143], 'heterozygote': [151], 'was': [152], 'associated': [153], 'compensatory': [156], 'up-regulation': [157], 'phosphorylation': [160], 'activity.': [162], 'Thus': [163], 'production,': [168], 'stress,': [170], 'functional': [171], 'decline,': [172], 'initiation': [175], 'apoptosis': [177], 'appear': [178], 'to': [179], 'be': [180], 'central': [181], 'components': [182], 'process.': [186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2106090797', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 19}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 25}], 'updated_date': '2024-12-12T19:55:29.189364', 'created_date': '2016-06-24'}