Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2105698873', 'doi': 'https://doi.org/10.2147/ndt.s31248', 'title': 'Role of oral teriflunomide in the management of multiple sclerosis', 'display_name': 'Role of oral teriflunomide in the management of multiple sclerosis', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W2105698873', 'doi': 'https://doi.org/10.2147/ndt.s31248', 'mag': '2105698873', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23637535', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3639219'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/ndt.s31248', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=15861', 'source': {'id': 'https://openalex.org/S124245730', 'display_name': 'Neuropsychiatric Disease and Treatment', 'issn_l': '1176-6328', 'issn': ['1176-6328', '1178-2021'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=15861', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055313284', 'display_name': 'Cris S. Constantinescu', 'orcid': 'https://orcid.org/0000-0003-2066-7585'}, 'institutions': [{'id': 'https://openalex.org/I142263535', 'display_name': 'University of Nottingham', 'ror': 'https://ror.org/01ee9ar58', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I142263535']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Cris Constantinescu', 'raw_affiliation_strings': ['Academic Division of Clinical Neurology, University of Nottingham, Nottingham, UK'], 'affiliations': [{'raw_affiliation_string': 'Academic Division of Clinical Neurology, University of Nottingham, Nottingham, UK', 'institution_ids': ['https://openalex.org/I142263535']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002722246', 'display_name': 'Nikos Evangelou', 'orcid': 'https://orcid.org/0000-0003-2871-0672'}, 'institutions': [{'id': 'https://openalex.org/I142263535', 'display_name': 'University of Nottingham', 'ror': 'https://ror.org/01ee9ar58', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I142263535']}, {'id': 'https://openalex.org/I162051807', 'display_name': 'Carol Davila University of Medicine and Pharmacy', 'ror': 'https://ror.org/04fm87419', 'country_code': 'RO', 'type': 'education', 'lineage': ['https://openalex.org/I162051807']}], 'countries': ['GB', 'RO'], 'is_corresponding': False, 'raw_author_name': 'None Tanasescu', 'raw_affiliation_strings': ['Academic Division of Clinical Neurology, University of Nottingham, Nottingham, UK', 'Department of Neurology, Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania'], 'affiliations': [{'raw_affiliation_string': 'Academic Division of Clinical Neurology, University of Nottingham, Nottingham, UK', 'institution_ids': ['https://openalex.org/I142263535']}, {'raw_affiliation_string': 'Department of Neurology, Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania', 'institution_ids': ['https://openalex.org/I162051807']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055313284', 'display_name': 'Cris S. Constantinescu', 'orcid': 'https://orcid.org/0000-0003-2066-7585'}, 'institutions': [{'id': 'https://openalex.org/I142263535', 'display_name': 'University of Nottingham', 'ror': 'https://ror.org/01ee9ar58', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I142263535']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'None Evangelou', 'raw_affiliation_strings': ['Academic Division of Clinical Neurology, University of Nottingham, Nottingham, UK'], 'affiliations': [{'raw_affiliation_string': 'Academic Division of Clinical Neurology, University of Nottingham, Nottingham, UK', 'institution_ids': ['https://openalex.org/I142263535']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'apc_paid': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'fwci': 0.969, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.833285, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': None, 'issue': None, 'first_page': '539', 'last_page': '539'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10137', 'display_name': 'Diagnosis and Pathogenesis of Multiple Sclerosis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10137', 'display_name': 'Diagnosis and Pathogenesis of Multiple Sclerosis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11616', 'display_name': 'Hemophagocytic Lymphohistiocytosis and Related Disorders', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10950', 'display_name': 'Epidemiology and Treatment of Childhood Leukemia', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/teriflunomide', 'display_name': 'Teriflunomide', 'score': 0.99557626}, {'id': 'https://openalex.org/keywords/treatment-outcomes', 'display_name': 'Treatment Outcomes', 'score': 0.456947}], 'concepts': [{'id': 'https://openalex.org/C2777703276', 'wikidata': 'https://www.wikidata.org/wiki/Q3077133', 'display_name': 'Teriflunomide', 'level': 4, 'score': 0.99557626}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93276614}, {'id': 'https://openalex.org/C2780640218', 'wikidata': 'https://www.wikidata.org/wiki/Q8277', 'display_name': 'Multiple sclerosis', 'level': 2, 'score': 0.87411934}, {'id': 'https://openalex.org/C2776036978', 'wikidata': 'https://www.wikidata.org/wiki/Q425137', 'display_name': 'Fingolimod', 'level': 3, 'score': 0.87039036}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.713007}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.46066892}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3756027}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.34661755}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.30381855}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.19925898}], 'mesh': [], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/ndt.s31248', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=15861', 'source': {'id': 'https://openalex.org/S124245730', 'display_name': 'Neuropsychiatric Disease and Treatment', 'issn_l': '1176-6328', 'issn': ['1176-6328', '1178-2021'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/80d40c8d91304dd493f0e94de2b27fd1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3639219', 'pdf_url': 'https://europepmc.org/articles/pmc3639219?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://nottingham-repository.worktribe.com/output/714335', 'pdf_url': 'https://nottingham-repository.worktribe.com/preview/714345/ndt-9-539.pdf', 'source': {'id': 'https://openalex.org/S4306402482', 'display_name': 'Repository@Nottingham (University of Nottingham)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I142263535', 'host_organization_name': 'University of Nottingham', 'host_organization_lineage': ['https://openalex.org/I142263535'], 'host_organization_lineage_names': ['University of Nottingham'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://nottingham-repository.worktribe.com/file/714335/1/ndt-9-539.pdf', 'pdf_url': 'https://nottingham-repository.worktribe.com/file/714335/1/ndt-9-539.pdf', 'source': {'id': 'https://openalex.org/S4306402483', 'display_name': 'Repository@Nottingham (University of Nottingham)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I142263535', 'host_organization_name': 'University of Nottingham', 'host_organization_lineage': ['https://openalex.org/I142263535'], 'host_organization_lineage_names': ['University of Nottingham'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639219', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23637535', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/ndt.s31248', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=15861', 'source': {'id': 'https://openalex.org/S124245730', 'display_name': 'Neuropsychiatric Disease and Treatment', 'issn_l': '1176-6328', 'issn': ['1176-6328', '1178-2021'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.76, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 65, 'referenced_works': ['https://openalex.org/W1493442750', 'https://openalex.org/W1547532383', 'https://openalex.org/W1742875372', 'https://openalex.org/W1930623285', 'https://openalex.org/W1967704295', 'https://openalex.org/W1967838438', 'https://openalex.org/W1972752407', 'https://openalex.org/W1973497933', 'https://openalex.org/W1979811627', 'https://openalex.org/W1981690748', 'https://openalex.org/W1986991730', 'https://openalex.org/W1992936160', 'https://openalex.org/W1995319242', 'https://openalex.org/W2006833922', 'https://openalex.org/W2008544379', 'https://openalex.org/W2013610409', 'https://openalex.org/W2014377555', 'https://openalex.org/W2029233703', 'https://openalex.org/W2042067959', 'https://openalex.org/W2043591841', 'https://openalex.org/W2049498103', 'https://openalex.org/W2051165446', 'https://openalex.org/W2056843315', 'https://openalex.org/W2057853327', 'https://openalex.org/W2060602500', 'https://openalex.org/W2064775943', 'https://openalex.org/W2066267467', 'https://openalex.org/W2071583027', 'https://openalex.org/W2078904865', 'https://openalex.org/W2079729577', 'https://openalex.org/W2084629567', 'https://openalex.org/W2090686076', 'https://openalex.org/W2092972484', 'https://openalex.org/W2093009907', 'https://openalex.org/W2098650638', 'https://openalex.org/W2104948944', 'https://openalex.org/W2108183290', 'https://openalex.org/W2114360739', 'https://openalex.org/W2114918986', 'https://openalex.org/W2122397885', 'https://openalex.org/W2122545833', 'https://openalex.org/W2122987434', 'https://openalex.org/W2122999365', 'https://openalex.org/W2123531724', 'https://openalex.org/W2131078277', 'https://openalex.org/W2133789608', 'https://openalex.org/W2134951629', 'https://openalex.org/W2137064637', 'https://openalex.org/W2139204856', 'https://openalex.org/W2140767387', 'https://openalex.org/W2142577589', 'https://openalex.org/W2148447161', 'https://openalex.org/W2149021083', 'https://openalex.org/W2151340435', 'https://openalex.org/W2155441883', 'https://openalex.org/W2228301361', 'https://openalex.org/W2237437108', 'https://openalex.org/W2312482418', 'https://openalex.org/W2409131906', 'https://openalex.org/W2746562707', 'https://openalex.org/W4211254511', 'https://openalex.org/W4255417130', 'https://openalex.org/W55510815', 'https://openalex.org/W81532596', 'https://openalex.org/W85830917'], 'related_works': ['https://openalex.org/W3155989692', 'https://openalex.org/W3131449471', 'https://openalex.org/W2971309441', 'https://openalex.org/W2739756297', 'https://openalex.org/W2587994165', 'https://openalex.org/W2548126365', 'https://openalex.org/W2396717041', 'https://openalex.org/W2324064861', 'https://openalex.org/W2083083635', 'https://openalex.org/W2052555685'], 'abstract_inverted_index': {'Abstract:': [0], 'The': [1, 102], 'landscape': [2], 'of': [3, 6, 24, 27, 86, 89, 104, 109], 'the': [4, 25, 87, 107], 'treatment': [5, 108], 'relapsing–remitting': [7, 40, 110], 'multiple': [8, 41, 111, 117], 'sclerosis': [9, 112], 'is': [10, 57, 113], 'changing': [11], 'fast.': [12], 'Several': [13], 'oral': [14, 31, 119], 'treatments': [15], 'have': [16, 36, 45, 69], 'shown': [17, 70], 'benefit': [18], 'and': [19, 34, 50, 65, 76, 91, 93], 'generate': [20], 'much': [21], 'interest': [22], 'because': [23], 'convenience': [26], 'their': [28], 'administration.': [29], 'Two': [30], 'compounds,': [32], 'fingolimod': [33], 'teriflunomide,': [35, 116], 'been': [37], 'approved': [38], 'in': [39, 73, 106], 'sclerosis,': [42, 118], 'while': [43], 'others': [44], 'completed': [46], 'Phase': [47], 'III': [48], 'trials': [49, 98, 122], 'are': [51], 'awaiting': [52], 'review': [53], 'for': [54], 'registration.': [55], 'Teriflunomide': [56], 'a': [58, 77], 'pyrimidine': [59], 'synthesis': [60], 'inhibitor': [61], 'with': [62, 99], 'selective': [63], 'immunomodulatory': [64], 'immunosuppressive': [66], 'properties': [67], 'that': [68], 'consistent': [71], 'efficacy': [72, 92], 'clinical': [74, 97, 121], 'trials,': [75], 'good': [78], 'safety': [79, 94], 'profile.': [80], 'This': [81], 'paper': [82], 'provides': [83], 'an': [84], 'overview': [85], 'mechanisms': [88], 'action': [90], 'results': [95], 'from': [96], 'this': [100], 'drug.': [101], 'role': [103], 'teriflunomide': [105], 'discussed.': [114], 'Keywords:': [115], 'drugs,': [120]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2105698873', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-31T22:56:05.013533', 'created_date': '2016-06-24'}