Publication Information

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2409, 2449, 2453, 2463, 2477, 2538, 2595, 2601, 2620, 2669, 2761, 2843, 2918, 2963, 3013, 3028, 3044, 3073, 3076, 3116, 3124, 3134, 3148, 3192, 3202, 3230, 3306, 3341, 3366, 3401, 3408, 3432, 3500, 3554, 3559, 3567, 3572, 3594, 3619, 3650, 3661, 3668, 3673, 3682, 3711, 3745, 3758, 3798, 3823, 3850, 3863, 3882, 3887, 3918, 3977, 4025, 4097, 4115, 4118, 4131, 4156, 4183, 4204, 4248, 4253, 4273, 4342, 4348, 4380, 4413, 4421, 4435, 4456, 4463, 4501, 4507, 4521, 4532, 4550, 4575, 4626, 4641, 4657, 4679, 4693, 4703, 4780, 4847, 4854, 4863, 4878, 4888, 4974, 5010, 5015, 5033, 5050, 5060, 5063, 5077, 5088, 5093, 5130, 5161, 5172, 5185, 5250, 5265, 5293, 5299, 5330, 5333, 5343, 5351, 5379], 'genetic': [14, 38, 54, 1217, 1252, 2170, 2540, 4171], 'information': [15, 2339], 'between': [16, 254, 1522, 2002, 2736, 2798, 2812, 2882, 3270, 4256, 4952], 'two': [17, 125, 241, 559, 567, 1265, 1662, 1850, 1874, 1916, 2191, 2332, 2927, 2944, 3142, 3287, 5288], 'homologous': [18, 112, 126, 235, 272, 306, 1213, 1688, 2410, 2454, 3135, 3143, 3160, 3219, 3916, 4794, 4842], 'molecules.': [20], 'It': [21, 1309, 1757, 2132, 2776, 3325, 3875, 4327, 4540, 4761, 5194, 5238], 'is': [22, 152, 217, 221, 262, 297, 317, 337, 528, 852, 947, 956, 1016, 1088, 1140, 1151, 1277, 1293, 1378, 1653, 1767, 1985, 2133, 2234, 2299, 2315, 2337, 2530, 2848, 2891, 2922, 2934, 3001, 3022, 3052, 3060, 3088, 3127, 3234, 3277, 3302, 3326, 3338, 3417, 3424, 3458, 3477, 3483, 3507, 3523, 3615, 3656, 3664, 3677, 3698, 3723, 3876, 3947, 4120, 4206, 4221, 4232, 4250, 4292, 4312, 4321, 4335, 4447, 4582, 4613, 4719, 4762, 4891, 4988, 5195, 5313], 'critically': [23, 4121], 'important': [24, 1351, 3753, 4020], 'in': [25, 58, 64, 175, 203, 213, 295, 300, 313, 462, 467, 469, 512, 515, 517, 643, 667, 874, 878, 889, 1018, 1117, 1248, 1323, 1456, 1499, 1534, 1577, 1601, 1702, 1711, 1720, 1734, 1747, 1769, 2064, 2141, 2237, 2266, 2317, 2347, 2361, 2379, 2470, 2549, 2654, 2674, 2704, 2742, 2753, 2823, 2825, 2950, 2971, 3023, 3153, 3163, 3239, 3462, 3561, 3625, 3637, 3743, 3755, 3766, 3940, 3957, 3970, 4022, 4105, 4168, 4208, 4266, 4316, 4394, 4405, 4558, 4707, 4728, 4774, 4813, 4834, 4844, 4956, 4990, 5002, 5036, 5057, 5067, 5097, 5175, 5217, 5303, 5315, 5336], 'fundamental': [26], 'processes': [27], 'such': [28, 394, 505, 671, 908, 2164, 2277, 3997, 4148, 4374, 4983, 5267], 'repair': [31, 2533, 4895, 4944, 5062, 5129, 5190], 'genotoxic': [33], 'lesions,': [34, 5132], 'creation': [36, 431], 'diversity,': [39], 'proper': [41, 3865], 'segregation': [42], 'chromosomes': [44], 'and': [45, 55, 63, 105, 129, 157, 168, 243, 274, 286, 290, 344, 389, 402, 476, 484, 504, 514, 537, 583, 605, 633, 662, 700, 703, 710, 755, 809, 821, 838, 864, 896, 901, 916, 939, 980, 991, 1080, 1158, 1163, 1175, 1255, 1258, 1292, 1306, 1340, 1421, 1435, 1497, 1527, 1545, 1616, 1638, 1646, 1667, 1699, 1780, 1828, 1838, 1847, 1857, 1863, 1870, 1912, 1923, 1955, 1960, 2004, 2032, 2079, 2086, 2093, 2100, 2171, 2184, 2326, 2389, 2406, 2484, 2499, 2507, 2534, 2561, 2591, 2608, 2632, 2672, 2695, 2710, 2738, 2804, 2816, 2852, 2860, 2873, 2886, 2913, 2961, 3021, 3093, 3242, 3273, 3317, 3355, 3361, 3386, 3405, 3449, 3453, 3456, 3473, 3547, 3601, 3632, 3692, 3750, 3775, 3794, 3811, 3840, 3855, 3890, 3903, 3932, 3960, 4028, 4045, 4054, 4111, 4191, 4199, 4240, 4283, 4287, 4407, 4496, 4524, 4578, 4648, 4664, 4758, 4796, 4817, 4918, 4930, 4959, 5091, 5120, 5178, 5207, 5226, 5281, 5366], 'restart': [47, 403], 'stalled': [49, 374], 'replication': [51, 375, 407, 2717, 5083, 5095, 5187, 5232], 'forks.': [52], 'Detailed': [53], 'biochemical': [56, 252, 1352, 3284], 'analyses': [57], 'bacterium': [60, 646, 4213], 'Escherichia': [61], 'coli': [62, 591, 654, 782, 794, 813, 1417, 1543, 1978, 2214, 2440, 2472, 2557, 2685, 2755, 3031, 3156, 3852, 4629, 4815, 5099, 5278], 'yeast': [66], 'Saccharomyces': [67], 'cerevisiae': [68], 'led': [69], 'to': [70, 136, 197, 199, 269, 319, 339, 384, 499, 529, 542, 656, 663, 673, 736, 745, 834, 905, 926, 935, 958, 971, 981, 1007, 1071, 1104, 1132, 1147, 1190, 1210, 1380, 1382, 1389, 1494, 1541, 1557, 1569, 1635, 1674, 1676, 1689, 1805, 1934, 2016, 2110, 2120, 2135, 2155, 2378, 2398, 2401, 2523, 2532, 2563, 2584, 2629, 2682, 2715, 2992, 3108, 3130, 3176, 3222, 3351, 3356, 3419, 3460, 3465, 3488, 3509, 3517, 3526, 3565, 3599, 3602, 3604, 3641, 3678, 3716, 3735, 3783, 3792, 3802, 3911, 3949, 3963, 4008, 4017, 4050, 4070, 4081, 4091, 4188, 4216, 4264, 4276, 4337, 4356, 4368, 4370, 4391, 4416, 4449, 4517, 4544, 4561, 4563, 4606, 4620, 4688, 4715, 4748, 4809, 4861, 4948, 4980, 5022, 5071, 5124, 5153, 5258, 5317], 'realization': [72], 'that': [73, 620, 629, 740, 867, 945, 1014, 1036, 1135, 1202, 1223, 1312, 1518, 1537, 1551, 1564, 1583, 1595, 1642, 1682, 1762, 1816, 1898, 2138, 2175, 2257, 2268, 2497, 2508, 2529, 2543, 2605, 2616, 2780, 2840, 2892, 2939, 3084, 3126, 3173, 3226, 3329, 3373, 3394, 3406, 3421, 3479, 3493, 3535, 3611, 3697, 3719, 3739, 3879, 3924, 3951, 4229, 4295, 4315, 4330, 4451, 4528, 4590, 4766, 4777, 4804, 4935, 5039, 5197, 5241, 5275], 'divided': [78], 'into': [79, 428, 452, 1279, 3658, 4799, 5327], 'four': [80], 'successive': [81], 'steps,': [82], 'with': [83, 1011, 1195, 1833, 2160, 2713, 2936, 3025, 3159, 3435, 3439, 3514, 3729, 3786, 4358, 4362, 4571, 4742, 5113, 5142, 5158, 5182, 5230, 5254, 5260], 'each': [84, 562, 1748, 2156, 3407, 3422, 5082], 'step': [85, 120, 151, 312], 'requiring': [86], 'co-ordinated': [88, 3821], 'action': [89, 557, 576, 775], 'large': [92, 854, 1504, 1950, 4129, 4378], 'number': [93, 595, 1114, 1738, 4130, 5076], 'proteins': [95, 194, 786, 866, 1809, 2163, 3779], '(for': [96, 691, 1298, 2367], 'review,': [98], 'see': [99, 693, 1300], 'Kowalczykowski': [100, 695, 1301, 5345], 'et': [101, 182, 186, 472, 480, 523, 570, 696, 995, 999, 1063, 1067, 1076, 1302, 1400, 1404, 1408, 1607, 1613, 1620, 1776, 1798, 1842, 1866, 1895, 1905, 1982, 1994, 2372, 2420, 2424, 2429, 2457, 2488, 2493, 2657, 2661, 2665, 2719, 2723, 2728, 2773, 2791, 2828, 2864, 2868, 2995, 3018, 3183, 3187, 3322, 3390, 3469, 3588, 3629, 3644, 3706, 3807, 3815, 3898, 3987, 3992, 4140, 4144, 4195, 4307, 4424, 4429, 4440, 4734, 4754, 4898, 4902, 4964, 5105, 5146, 5235], 'al.,': [102, 183, 187, 473, 481, 524, 571, 697, 996, 1000, 1064, 1068, 1077, 1303, 1401, 1405, 1409, 1608, 1614, 1621, 1777, 1799, 1843, 1867, 1896, 1906, 1983, 1995, 2373, 2421, 2425, 2430, 2458, 2489, 2494, 2658, 2662, 2666, 2720, 2724, 2729, 2774, 2792, 2829, 2865, 2869, 2996, 3019, 3184, 3188, 3323, 3391, 3470, 3589, 3630, 3645, 3707, 3808, 3816, 3899, 3988, 3993, 4141, 4145, 4196, 4308, 4425, 4430, 4441, 4735, 4755, 4899, 4903, 4965, 5106, 5147, 5236], '1994;': [103, 698, 1304, 1402, 3813], 'Pâques': [104], 'Haber,': [106], '1999).': [107, 1410, 2730, 3646, 3708, 3994, 4242, 5237], 'At': [108], 'heart': [110], 'lies': [114], 'strand-exchange': [117, 193, 259, 276, 332], 'step.': [118], 'This': [119, 219, 334, 411, 548, 649, 677, 1029, 1057, 1109, 1240, 1548, 2222, 2574, 2932, 2998, 3062, 3550, 4386, 4933, 5149, 5369], 'involves': [121, 4040], 'alignment': [123], 'molecules': [128, 242, 4305], 'their': [133, 172, 248, 711, 750, 2344, 2516, 2670, 2675, 3282, 4403, 4414, 4559, 4708, 4729, 4740, 5179, 5211, 5218, 5310, 5348], 'complementary': [134], 'strands': [135, 2928, 3400], 'produce': [137, 320, 500, 543, 1191], 'joint': [139], 'mole-cule.': [141], 'In': [142, 189, 1626, 1908, 2006, 2385, 2443, 2807, 2831, 3034, 3943, 4443, 4851, 4875], 'E.': [143, 590, 653, 781, 793, 812, 875, 1416, 1524, 1542, 1572, 1977, 2213, 2439, 2471, 2556, 2622, 2684, 2754, 2801, 3030, 3155, 3767, 3851, 4106, 4628, 4814, 5068, 5098, 5277], 'coli,': [144, 3768, 4107], 'main': [146, 348, 870, 2451, 4883, 5135], 'protein': [147, 162, 796, 801, 1209, 1235, 1393, 1818, 1980, 2216, 3158, 3685, 3722, 3732, 3747, 3782, 3789, 3854, 3889, 4662], 'involved': [148, 1017, 2316], 'this': [150, 351, 602, 723, 1245, 1269, 1324, 1460, 1513, 1584, 1789, 1812, 1817, 2249, 2312, 3520, 3531, 3712, 3741, 3907, 3944, 3971, 4037, 4082, 4205, 4319, 4444, 4479, 4580, 4717, 4767, 4788, 4865, 4995, 5051, 5143, 5189, 5198], 'RecA': [154, 161, 847, 1208, 1234, 1392, 3684, 3721, 3746, 3781, 3824, 3853, 3888], 'protein.': [155, 848], 'Structural': [156], 'functional': [158, 1520, 3617, 4552, 4593], 'homologues': [159, 1484, 1708, 1717, 2047, 2262, 2619, 4520], 'have': [163, 741, 1443, 1623, 2054, 3095, 3289, 3748, 3870, 4067, 4617], 'been': [164, 426, 460, 509, 598, 607, 924, 1286, 1445, 1624, 1760, 2056, 2821, 3831, 4058, 4068, 4535, 4807, 4937, 5055], 'discovered': [165, 3671], 'throughout': [166, 4538, 4939], 'Eukarya': [167], 'Archaea,': [169], 'thus': [170, 2794, 3111], 'emphasizing': [171], 'critical': [173, 3178, 5349], 'role': [174, 1322, 2342, 3754, 3969, 4021, 4934], 'all': [176, 190, 266, 1627, 4998], 'forms': [177], 'cellular': [179, 2348], 'life': [180], '(Bianco': [181], '1998;': [184, 478, 2725, 3185, 4961], 'Seitz': [185, 5365], '1998).': [188, 2431, 2667, 2775, 4146, 4289, 4932, 5148], 'cases,': [191, 1628], 'are': [195, 283, 621, 1043, 1538, 1683, 1709, 1718, 1755, 1876, 1883, 1946, 2187, 2263, 2269, 2329, 2502, 2513, 2617, 2689, 2702, 2707, 2841, 3379, 4005, 4015, 4136, 4187, 4384, 4453, 4555, 4569, 4632, 4725, 4927, 5215], 'able': [196, 4336, 4605], 'bind': [198, 3375], 'single-stranded': [200, 502, 539, 762, 3119], '(ssDNA)': [202], 'co-operative': [205], 'way,': [206], 'forming': [207], 'highly': [209], 'ordered': [210], 'nucleoprotein': [211, 3800], 'fila-ment': [212], 'which': [214, 314, 397, 954, 1024, 1274, 2118, 2335, 3082, 3310, 3437, 3457, 3609, 3868, 4039, 4150, 4459, 4510, 4674, 4737, 5138, 5309], 'extended.': [218], 'filament': [220, 3801], 'active': [223], 'species': [224, 1740, 1751, 3896, 4548, 4589], 'protein:': [227], 'it': [228, 1361, 1377, 1385, 1516, 2255, 2298, 2847, 3416, 3476, 3533, 3920, 3946, 3961, 4291, 4311, 4446], 'carries': [229, 2766, 3141, 3411], 'out': [230, 3247, 4390], 'search': [232], 'for': [233, 309, 327, 593, 601, 713, 722, 953, 1261, 1429, 1449, 1660, 1788, 1811, 1823, 2026, 2334, 2438, 2481, 2515, 2693, 2698, 2733, 2744, 2903, 2990, 3004, 3113, 3179, 3260, 3382, 3485, 3733, 3790, 3833, 3980, 4075, 4123, 4298, 4400, 4458, 4482, 4601, 4793, 4885, 4971, 5117, 5201, 5223, 5347], 'duplex': [236, 450, 494, 3404], 'partner,': [238], 'pairs': [239], 'catalyses': [244], 'strands.': [249, 455], 'Despite': [250, 1512], 'some': [251, 2550, 2679, 5323], 'differences': [253, 666], 'various': [256, 2094, 3164, 3203], 'known': [257, 925, 1761, 2019, 3236, 3459, 3878, 4294, 4516], 'proteins,': [260, 815, 817, 2020, 3919, 4526], 'ssDNA': [261, 325, 433, 546, 829, 1247, 3316, 3690, 3793], 'universally': [263, 3129], 'used': [264, 498, 833, 1576, 3128, 3861, 4069, 4808], 'by': [265, 382, 437, 457, 552, 773, 845, 1033, 1052, 1086, 1095, 1170, 1206, 1273, 1415, 1441, 1861, 1948, 2042, 2058, 2218, 2282, 2292, 2414, 2588, 2647, 2895, 2920, 2965, 3312, 3428, 3498, 3528, 3544, 3576, 3583, 3652, 3701, 3825, 3975, 4094, 4154, 4179, 4584, 4638, 4915, 4994, 5137, 5168, 5308, 5373], 'them': [268, 4052], 'initiate': [270, 674, 835, 1211, 2524, 3131, 5125], 'pairing': [273, 837, 1214], 'events,': [277], 'although': [278, 1327, 4310, 4331], 'other': [279, 1528, 1834, 1962, 2018, 2073, 2157, 2161, 2510, 3505, 3925, 5202], 'modes': [280], 'initiation': [282, 342, 419, 1452, 3757, 4024, 4340, 5032], 'possible': [284], '(Mazin': [285], 'Kowalczykowski,': [287, 291, 477, 1081, 1159, 1164, 1256, 2876, 2914, 3474, 3693, 3843, 5108], '1999;': [288, 482], 'Zaitsev': [289], '2000).': [292, 410, 2830, 2997, 3189, 4442, 4698, 5109], 'Since': [293], 'cells': [296, 904, 4093, 4186, 4355, 5021, 5139, 5253], 'normally': [298, 3542], 'found': [299, 3003, 3152, 3162, 4207, 4928, 4989, 5001], 'double-stranded': [302, 766, 789, 4100, 4133, 4381], 'B': [303], 'form': [304], '(dsDNA),': [305], 'calls': [308], 'first': [311, 335, 1266], 'dsDNA': [316, 357, 416, 423, 931, 978, 1101, 1193, 1597, 2521, 2762, 2858, 4043, 4304, 5065, 5078, 5269], 'processed': [318], 'suitable': [322], 'substrate': [323], '–': [324, 326, 787, 802], 'binding': [329, 988, 3734, 3791], 'proteins.': [333, 3166, 3205, 3777], 'phase': [336, 343, 1215, 4341], 'referred': [338, 735, 934, 2377, 2628], 'will': [345, 413, 679, 704, 725, 830, 1091, 2375, 2626, 4790, 5320], 'focus': [349, 609], 'review.': [352], 'Initiation': [353, 456], 'sites': [354, 5174], 'include': [355], 'both': [356, 511, 581, 631, 1644, 2169, 2386, 2589, 2849, 3399, 3620], 'breaks,': [358], 'either': [359, 777, 1550, 4464], "'normal'": [360], 'physiological': [361], 'breaks': [362, 379, 417, 4135, 4383, 4438, 5066, 5079], '(e.g.': [363, 380, 393, 780, 792, 811], 'programmed': [364], 'during': [365, 1885, 5081], 'course': [367], 'meiosis': [369], 'or': [370, 377, 386, 573, 784, 797, 804, 818, 881, 912, 976, 1563, 1744, 2023, 2274, 2286, 2310, 2395, 2417, 2466, 2651, 3369, 3376, 3983, 4001, 4166, 4367, 4466, 4595, 4833, 4922, 4986], 'formed': [371, 4914], 'fork)': [376, 408], 'pathological': [378], 'caused': [381], 'exposure': [383], 'γ-radiation': [385], 'certain': [387], 'chemicals),': [388], 'single-strand': [390], 'gaps': [392], 'those': [396, 1629, 2436], 'exist': [398, 3765], 'after': [399], 'collapse': [401, 5092], '(Kowalczykowski,': [409], 'review': [412, 678, 724], 'primarily': [414], 'discuss': [415], 'sites.': [420], 'Once': [421], 'break': [424, 768], 'has': [425, 459, 507, 606, 636, 922, 967, 1285, 1758, 2820, 3829, 4057, 4534, 4771, 4805, 4840, 4936, 5054], 'introduced': [427], 'DNA,': [429, 1181, 4864], 'achieved': [436, 551, 772], 'several': [438, 1500, 1784], 'means': [439, 4979], '(Fig.': [440, 1124, 1510, 2103, 2929, 4077], '1).': [441, 4078], 'helicases': [443, 458, 779, 808, 1954], 'catalyse': [445, 3357, 4338], 'separation': [447], 'its': [453, 1176, 1439, 2805, 2817, 3358, 3409, 3433, 3605, 4689, 4868, 4920, 4923, 5114, 5121], 'individual': [454], 'documented': [461, 510], 'vivo': [463, 513, 2655, 2743], 'well': [465, 4536], 'vitro': [468, 516, 2826], 'bacteria': [470, 1536, 1603, 1664, 4457], '(Thaler': [471], '1989;': [474, 4900], 'Harmon': [475], 'Churchill': [479, 1407, 3643], 'Cohen': [483], 'Sinclair,': [485], '2001).': [486, 1001], 'Double-stranded': [487], 'exonucleases': [488, 791], 'degrading': [489], 'one': [490, 564, 578, 2448, 2972, 3066, 3429], 'strand': [491, 840, 1156, 1398, 2906, 3423, 3442, 4437], 'also': [496, 508, 694, 726, 948, 1221, 1899, 1986, 2235, 2611, 2778, 3002, 3699, 3955, 4946, 5151], 'region': [503, 827], 'processing': [506], 'different': [518, 623, 1578, 2068, 2319, 3292], 'organisms': [519, 2108, 2267, 2333, 4503], '(Little,': [520], '1967;': [521], 'Kolodner': [522], '1994).': [525, 1308], 'Another': [526, 4243], 'possibility': [527], 'associate': [530], 'activities': [532, 568, 748, 1353, 1440, 2839], 'helicase': [536, 582, 632, 1367, 1645, 1964, 3340, 3557, 3570], 'nuclease': [541, 584, 634, 1038, 1134, 1149, 1371, 1969, 2039, 2583, 2587, 2946, 3050, 3058, 3078, 3144, 3150, 3180, 3196, 3414, 4044, 5026, 5164], 'desired': [545], 'region.': [547], 'coupling': [554], 'distinct': [560], 'enzymes,': [561, 5301], 'contributing': [563], '(Lovett': [569], '1988),': [572], 'from': [574, 624, 638, 764, 1102, 1179, 1598, 2230, 2580, 2643, 2983, 3257, 3348, 3893, 4086, 4245, 4323, 4634, 4751, 5375], 'enzyme': [579, 588, 754, 820, 851, 921, 966, 1042, 1123, 1174, 1189, 1227, 1345, 1419, 1425, 1434, 1641, 1652, 1672, 1921, 2346, 2360, 2559, 2579, 2653, 2815, 2837, 2885, 2898, 2942, 2956, 2968, 2975, 3101, 3140, 3397, 3655, 3676, 3704, 3828, 3859, 3892, 4004, 4334, 4468, 4637, 5280, 5286], 'containing': [580, 1486, 1706, 1715, 1741, 1752], 'activities.': [585], 'The': [586, 824, 849, 919, 1271, 1649, 1722, 1750, 1845, 1927, 3099, 3138, 3167, 3214, 3258, 3266, 3295, 3709, 4624, 4667, 4820, 4905, 5048, 5110], 'RecBCD': [587, 626, 687, 819, 850, 920, 946, 965, 1015, 1055, 1087, 1097, 1122, 1173, 1188, 1226, 1357, 1375, 1418, 1433, 1483, 1529, 1691, 1698, 1707, 1743, 1940, 2500, 2558, 2578, 2650, 2845, 2888, 2897, 2955, 3032, 3275, 3675, 3891, 4000, 4184, 4401, 4465, 4553, 4594, 4636, 4680, 4695, 4985, 5111, 5162, 5279], 'has,': [592], 'years,': [597], 'prototype': [600], 'latter': [603, 1585], 'category': [604], 'considerable': [611, 5075], 'attention.': [612], 'Recently,': [613], 'however,': [614, 1005, 1311, 1515, 2137, 2890, 3522, 4035, 4598, 4765], 'novel': [616, 1678], 'class': [617, 688, 729, 1679, 1692, 2128], 'enzymes': [619, 672, 690, 1530, 1681, 1701, 1836, 2130, 2180, 2501, 3276, 3288, 4982], 'structurally': [622], 'enzyme,': [627, 1376, 2889, 5012, 5112], 'but': [628, 1384, 1685, 1814], 'carry': [630], 'activities,': [635], 'emerged': [637], 'studies': [639, 943, 1220, 5059], 'Gram-positive': [645, 1663, 2116], 'Bacillus': [647, 1617], 'subtilis.': [648, 3942], 'discovery': [650, 1035], 'allowed': [651], 'paradigm': [655, 4822], 'made': [658], 'universal': [659], 'among': [660, 4011], 'Bacteria': [661], 'highlight': [664], 'interesting': [665, 2134, 2880, 3948, 4448, 4543], 'use': [669, 4656, 4702, 4747, 4973, 5014], 'recombination.': [676, 718, 759, 1218, 3137, 3760], 'briefly': [680], 'summarize': [681], 'our': [682, 714, 5328], 'current': [683], 'knowledge': [684], 'reviews,': [692, 1299], 'Myers': [699, 1305], 'Stahl,': [701, 1307, 4055, 4200], '1994)': [702], 'then': [705, 831, 3102], 'emphasize': [706], 'recent': [708, 5058], 'developments': [709], 'implications': [712], 'understanding': [715, 1450, 5329], 'Of': [719], 'central': [720], 'importance': [721], 'short': [731, 2690, 3319, 4829], 'sequences,': [733, 739, 2636, 5319], 'collectively': [734], 'Chi': [738, 1060], 'unique': [743, 969, 5122], 'ability': [744, 970, 1388, 4215, 4560, 5123], 'regulate': [746, 4981], 'own': [751, 4869], 'cognate': [752, 2818, 3606], 'helicase/nuclease': [753], 'thereby': [756], 'effect': [757], 'Creation': [760], '(top)': [769], 'RecBC': [783, 1344, 2273, 3703, 4333], 'RecQ': [785], 'left),': [788], 'DNA-specific': [790], 'RecE': [795], 'phage': [798, 2415, 4631, 4654, 4669, 4686], 'lambda': [799, 4668], 'Redα': [800], 'middle),': [803], 'combination': [806, 3849, 3917], 'nucleases': [810], 'RecQ–RecJ': [814], 'RecBC–RecJ': [816], 'χ–': [822], 'right).': [823, 2931], 'newly': [825], 'created': [826, 4153], 'homology-dependent': [836], 'exchange,': [841], 'reaction': [843], 'catalysed': [844], '(330': [855], 'kDa)': [856], 'heterotrimeric': [857], 'complex': [858, 1318, 2053, 3598, 4696], 'composed': [859, 2188], 'RecB,': [862, 1495, 3436], 'RecC': [863, 1496, 2022, 3546, 3578, 3622], 'RecD': [865, 1314, 1331, 2215, 2261, 2308, 3548, 3585, 3634, 4350], 'initiates': [868], 'pathway': [871, 3954, 4531, 4554], 'coli.': [876, 5069], 'Mutations': [877], 'recB': [880], 'recC': [882], 'genes': [883, 1851, 1875, 3985], 'cause': [884], 'about': [885], '100-fold': [887], 'decrease': [888], 'frequency': [891], 'conjugal': [893, 2485], '(Howard-Flanders': [895], 'Theriot,': [897], '1966;': [898], 'Emmerson,': [899, 3362], '1968)': [900], 'strongly': [902, 1141, 2708, 3922], 'sensitize': [903], 'DNA-damaging': [906, 2402], 'treatments': [907], 'UV': [910, 2482], 'light': [911], 'X-ray': [913], 'radiation': [914], '(Sargentini': [915], 'Smith,': [917, 992, 1546, 3450, 3454, 4759, 4818], '1986).': [918], 'long': [923, 1444, 1759], 'potent': [929, 1370, 2520, 2857, 3048], 'ATP-dependent': [930, 1790], 'exonuclease,': [932], 'often': [933], 'ExoV': [937, 1765, 1835, 4117, 4230, 4249, 4296], '(Telander-Muskavitch': [938], 'Linn,': [940], '1981).': [941], 'Subsequent': [942, 1580], 'showed': [944, 1222, 1582], 'processive': [950, 2853], 'helicase,': [952, 2855], 'unwinding': [955, 3097, 3359], 'coupled': [957], 'exonucleolytic': [959, 1599, 2545, 2644], 'degradation': [960, 1600, 2645, 2760, 2894, 2917], 'DNA.': [963, 1028, 2573], 'Notably,': [964], 'load': [972, 1390], 'onto': [973, 1236, 1394, 3686], 'blunt': [975], 'near-blunt': [977], 'end': [979], 'unwind': [982], 'more': [983, 2225, 3967, 4556, 4968, 5192], 'than': [984, 2226, 5245], '30': [985], 'kilobases': [986], 'per': [987], 'event': [989, 1111, 3087, 4776], '(Taylor': [990], '1985;': [993], 'Roman': [994], '1992;': [997, 2659, 3388], 'Bianco': [998, 1079, 3472], 'Its': [1002], 'degradative': [1003, 2582], 'function,': [1004, 5027], 'seems': [1006, 1673, 2119, 3962], 'odds': [1010], 'view': [1013, 1586], 'initiating': [1019], 'recombination,': [1021, 2411, 2526, 4344], 'process': [1023, 1250, 2528, 3133, 5038, 5332], 'requires': [1025, 2542], 'preservation': [1026], 'paradox': [1030], 'was': [1031, 1136, 1531, 1555, 1587, 1725, 2740, 2777, 3245, 3860, 5371], 'solved': [1032], 'properties': [1039], 'regulated': [1044, 2548, 5242, 5294, 5314], 'upon': [1045, 1336, 1727, 4160], 'recognition': [1046, 1110, 1167, 1276, 1338, 2962, 2991, 3038, 3086, 3092, 3499, 3649], 'specific': [1049, 1590, 2565, 2613, 5318], 'sequence': [1051, 1526, 1574, 1731, 2059, 2569, 2624, 2819, 2981, 3253, 5018], 'translocating': [1054, 1172, 2571], 'enzyme.': [1056, 1358, 1941, 3033], 'sequence,': [1058, 3071, 3608, 4787], 'called': [1059], '(χ;': [1061], 'Lam': [1062], '1974;': [1065], 'Stahl': [1066], '1975),': [1069], 'corresponds': [1070], 'octamer': [1073], '5′-GCTGGTGG-3′': [1074], '(Smith': [1075], '1981;': [1078], '1997).': [1082, 3324, 3590, 3817, 4201, 4819], 'Recognition': [1083], 'χ': [1085, 1090, 1139, 1169, 1201, 1275, 1337, 1442, 1631, 3607, 3626, 3651, 4723, 4786, 4975, 5173, 5213], 'polar:': [1089], 'only': [1092, 1533, 2190, 2331, 2958, 2969, 4825], 'recognized': [1094], 'molecule': [1098, 1194], 'travelling': [1099], 'through': [1100, 2572], 'right': [1103], 'left': [1105], 'written': [1107, 2988], 'above.': [1108], 'elicits': [1112], 'changes': [1116], 'behaviour': [1119, 2933, 3027], '2,': [1125, 2930], 'left).': [1126], 'Upon': [1127], 'recognition,': [1128], 'vigorous': [1130], '3′': [1131, 1148, 2985, 3109, 3464, 3487, 3518], '5′': [1133, 1146, 3107, 3466, 3489, 3516], 'present': [1137, 1768, 1971, 1987, 2264, 2638, 3198, 4706], 'before': [1138, 3068, 3080], 'downregulated,': [1142], 'while': [1143, 1713, 2570, 2893, 2953, 3055, 4683, 5028], 'weaker': [1145], 'activity': [1150, 1284, 1372, 1766, 1794, 2546, 3051, 3059, 3079, 3181, 3492, 3558, 3571, 3663, 4114, 4182, 4231, 4612, 4678, 4692, 5165], 'activated': [1152], 'on': [1153, 1972, 2639, 2925, 3299, 3503, 4224, 4827, 4867, 5030], 'opposite': [1155, 3512], '(Dixon': [1157, 1399, 2912], '1991,': [1160, 2459, 3989], '1993;': [1161, 2422, 2490, 3451, 3809, 3990, 4193], 'Anderson': [1162, 1403], '1997a).': [1165], 'After': [1166, 3091], 'eventual': [1177], 'dissociation': [1178, 1328], 'modifications': [1183], 'described': [1184, 2553], 'above': [1185], 'enable': [1186, 4353], '3′-ssDNA': [1197], 'tail': [1198], 'terminating': [1199], 'bound': [1205], 'Recent': [1219], 'χ-activated': [1225], 'directly': [1228, 4675], 'facilitates': [1229], 'loading': [1231, 3681, 3713, 3822], 'χ-terminated': [1238], 'ssDNA.': [1239, 3736], 'ensures': [1241], 'maximal': [1242], 'participation': [1243], 'χ-protected': [1246], '(Anderson': [1254, 3691], '1997b)': [1257], 'effectively': [1259, 4797, 5126], 'provides': [1260, 4297], 'co-ordination': [1262, 4992], 'steps': [1267], 'process.': [1270], 'mechanism': [1272, 5307], 'translated': [1278, 3657], 'change': [1281, 3660], 'enzymatic': [1283, 3662], 'subject': [1288, 3525], 'much': [1290, 3966], 'debate': [1291], 'still': [1294], 'not': [1295, 1334, 1686, 2012, 3235, 3524, 3830], 'clearly': [1296, 2173, 2270], 'understood': [1297], 'appears,': [1310], 'subunit': [1315, 1332, 1929, 1937, 2010, 3293, 3372, 3482, 3538, 3575, 3579, 3586, 3614, 3623, 3635, 4351], 'plays': [1319], 'major': [1321], 'regulation.': [1325, 4996], 'Indeed,': [1326, 4104, 5210], 'does': [1333, 2011], 'occur': [1335, 2993], '(Dohoney': [1339], 'Gelles,': [1341], '2001),': [1342, 4431], 'displays': [1346], 'most': [1347, 3267, 4500, 4871], 'recombinationally': [1350], 'χ-modified': [1356], 'Most': [1359], 'notably,': [1360], 'simply': [1362], 'functions': [1363, 2506, 2783, 3541, 3672, 5298], 'lacking': [1368], 'unable': [1379], 'respond': [1381, 3603], 'χ,': [1383], 'retains': [1386], '3′-terminated': [1396, 2905, 3118, 3441, 3689], '1997;': [1406, 2426, 2721, 2870, 3471, 4142, 4285, 5103, 5107], 'Processing': [1411], 'χ-containing': [1413], '(left)': [1420], 'B.': [1422, 1668, 1773, 1853, 1909, 2050, 2077, 2080, 2182, 2201, 2324, 2357, 2387, 2444, 2464, 2606, 2808, 2834, 3035, 3190, 3835, 3856, 3941, 3958, 5205, 5224, 5283], 'subtilis': [1423, 1618, 1774, 1854, 2051, 2183, 2202, 2325, 2358, 2388, 2465, 2607, 2835, 3836, 3857, 5206, 5225, 5284], 'AddAB': [1424, 1700, 1716, 1745, 1920, 2052, 2127, 2179, 2275, 2345, 2359, 2446, 2469, 2498, 2652, 2737, 2814, 2836, 2884, 2921, 2941, 2967, 3100, 3139, 3272, 3396, 3654, 3827, 3858, 4003, 4467, 4596, 4987, 5285], '(right).': [1426], 'See': [1427], 'text': [1428], 'details.': [1430], 'Although': [1431], 'regulation': [1437, 3527, 5167], 'considered': [1446], 'model': [1448], 'Bacteria,': [1457, 4699], 'evidence': [1458, 2602, 2732], 'supporting': [1459], 'assumption': [1461], 'was,': [1462], 'until': [1463], 'very': [1464, 3089, 3291], 'recently,': [1465], 'quite': [1466], 'limited.': [1467], 'Because': [1468, 3431], 'advance': [1471], 'genomic': [1473], 'sequencing,': [1474], 'we': [1475], 'now': [1477, 2055, 4006], 'ascertain': [1478], 'existence': [1480], 'true': [1482, 4393], '(i.e.': [1485], 'three': [1487, 2072, 3171], 'subunits': [1488, 1917, 2145, 2192, 3410], 'showing': [1489], 'extensive': [1490], 'amino': [1491], 'acid': [1492], 'homology': [1493, 1933, 2015, 2060, 2152, 3434], 'RecD)': [1498], 'genera,': [1501], 'encompassing': [1502], 'part': [1505, 1889], 'eubacterial': [1508, 1703], 'tree': [1509, 1724], '3).': [1511, 2104], 'prevalence,': [1514], 'appeared': [1517], 'interaction': [1521, 1554, 2575, 2735, 2811], 'coliχ': [1525, 1573, 2623, 2802], 'preserved': [1532, 4938], 'enteric': [1535], 'closely': [1539, 2434], 'related': [1540], '(McKittrick': [1544], '1989).': [1547], 'suggested': [1549], 'RecBCD–χ': [1553], 'restricted': [1556], 'small': [1559], 'group': [1560], 'microbes': [1562], 'functionally': [1565], 'equivalent': [1566], 'sequences': [1567, 1592, 1632, 2615, 2688, 4705, 4724, 4955, 4976, 5214], 'unrelated': [1568, 2253], 'canonical': [1571], 'were': [1575, 1633, 1795, 1859, 3174, 3255, 3910], 'organisms.': [1579], 'work': [1581, 5370], 'correct.': [1588], 'Short': [1589], '(5–8': [1593], 'bp)': [1594], 'protect': [1596, 2641], 'Lactococcus': [1604, 2082], 'lactis': [1605, 1666, 2186, 2239, 2328, 2468, 2610, 2749, 3006], '(Biswas': [1606, 4753], '1995),': [1609], 'Haemophilus': [1610], 'influenzae': [1611, 1651], '(Sourice': [1612], '1998)': [1615, 1622, 1897, 1984, 2374, 3631], '(Chédin': [1619, 2827, 2994], 'identified.': [1625], 'putative': [1630, 2029, 2209, 2945, 3195], 'believed': [1634, 3328], 'interact': [1636], 'with,': [1637], 'regulate,': [1639], 'an': [1640, 1824, 1879, 1957, 2734, 2785, 2861, 3491, 3752, 4019, 4087], 'possesses': [1643, 4783], 'exonuclease': [1647, 2522, 2859, 4102, 4181, 4611], 'activity.': [1648, 4103], 'H.': [1650], 'clear': [1655, 4461], 'homologue': [1656, 1746, 1754, 2210, 2309, 2354, 3305, 3618, 4462], 'RecBCD.': [1658], 'However,': [1659, 2245, 3846, 4499], 'L.': [1665, 2185, 2238, 2327, 2362, 2390, 2467, 2609, 2745, 2748, 3005, 5208, 5227], 'subtilis,': [1669, 1910, 2445, 2809, 3036, 3959], 'corresponding': [1671, 2649], 'belong': [1675, 2109], 'functionally,': [1684], 'structurally,': [1687], 'enzymes.': [1694], 'Distribution': [1695], 'genomes.': [1704, 4709], 'Groups': [1705], 'indicated': [1710, 1719], 'blue,': [1712], 'groups': [1714], 'green.': [1721], 'schematic': [1723], 'based': [1726, 3298], '16S': [1728], 'ribosomal': [1729], 'RNA': [1730], 'comparisons.': [1732], 'Numbers': [1733], 'parentheses': [1735], 'indicate': [1736, 3169, 3216], 'group.': [1749], 'given.': [1756], 'strong': [1764, 2901, 3726, 4099, 4772], 'crude': [1770], 'extracts': [1771], '(Chestukhin': [1775], '1972;': [1778], 'Ohi': [1779], 'Sueoka,': [1781], '1973).': [1782], 'Additionally,': [1783, 4290], 'mutant': [1785], 'strains': [1786, 3978, 4398], 'deficient': [1787, 4399], 'deoxyribonu-clease': [1791], '(add': [1792], 'locus)': [1793], 'identified': [1796, 1968, 2057], '(Doly': [1797, 1837], '1974).': [1800], 'Initial': [1801], 'purification': [1802], 'attempts': [1803], 'failed': [1804], 'identify': [1806], 'unambiguously': [1807], 'responsible': [1810, 3484], 'activity,': [1813, 3521], 'confirmed': [1815, 3913], 'shares': [1819], 'classic': [1821], 'requirements': [1822], 'energy': [1825, 3346], 'cofactor': [1826], '(ATP)': [1827], 'divalent': [1830], 'cation': [1831], '(Mg2+)': [1832], 'Anagnostopoulos,': [1839], '1976;': [1840], 'Shemyakin': [1841], '1979).': [1844], 'cloning': [1846], 'sequencing': [1848], 'encoding': [1852], 'ExoV,': [1855], 'addA': [1856, 1911, 2394], 'addB,': [1858], 'reported': [1860], 'Kooistra': [1862, 1869, 2423, 2867], 'colleagues': [1864], '(Kooistra': [1865, 2487], '1988;': [1868], 'Venema,': [1871], '1991).': [1872], 'These': [1873, 1942, 2432, 2635, 3778], 'organized': [1877], 'operon': [1880], 'and,': [1881, 3333, 3580, 5220, 5302], 'interestingly,': [1882], 'upregulated': [1884], 'competence': [1886], 'development': [1887], 'competence-specific': [1892], 'regulon': [1893], '(Hamoen': [1894], 'includes': [1900, 3552], 'recA': [1902], 'gene': [1903, 2220, 2250, 2284, 2294, 2313, 4660, 4811], '(Haijema': [1904, 1993, 2863], '1996a).': [1907], 'addB': [1913, 2396], 'encode': [1914, 4519], '(135': [1922], '141': [1924], 'kDa': [1925], 'respectively).': [1926, 2634], 'AddA': [1928, 1992, 2043, 3165, 3296, 3336, 3371, 3481, 3560], 'shows': [1930, 2838, 2899], 'regions': [1931, 1943, 3805], 'RecB': [1936, 1979, 2003, 3157, 3308, 3331, 3368, 3574], 'homo-logy': [1945], 'shared': [1947, 3700], 'family': [1951, 2259], 'define': [1956], 'ATP-binding': [1958, 2030], 'motif': [1959, 2031, 2040], 'five': [1961], 'potential': [1963, 5312], 'motifs.': [1965], 'A': [1966, 4967], 'recently': [1967, 2199, 3670], 'domain': [1970, 3151], 'C-terminus': [1974, 1990, 3201], '(Yu': [1981, 3182], '1996b),': [1996], 'further': [1997], 'extending': [1998], 'structural': [2000, 3300], 'conservation': [2001, 2140], 'AddA.': [2005], 'contrast,': [2007], 'AddB': [2009, 2144, 3204, 3537, 3595, 3613], 'show': [2013, 2146, 5274], 'substantial': [2014, 2338], 'including': [2021, 2071, 5204], 'RecD,': [2024], 'except': [2025], 'second': [2028, 2034, 3194], 'copy': [2035], 'same': [2038, 3895], 'carried': [2041, 3246, 3543], '(see': [2044, 2193, 4325], 'below).': [2045, 2194, 4326], 'Direct': [2046, 2731], 'and/or': [2061], 'direct': [2062, 3304, 3679], 'function': [2063, 3696, 3939, 5009], 'least': [2066, 2177, 5222], '12': [2067], 'bacterial': [2069, 4514, 4906], 'species,': [2070, 2143], 'bacilli': [2074], '(B.': [2075], 'anthracis,': [2076], 'stearothermophilus': [2078], 'halodurans),': [2081], 'lactis,': [2083, 2363, 2391, 5228], 'Clostridium': [2084, 2087], 'acetobutylicum': [2085], 'difficile,': [2088], 'Enterococcus': [2089], 'faecalis,': [2090], 'Staphylococcus': [2091], 'aureus': [2092], 'strep-tococci': [2095], '(S.': [2096, 2240], 'pyogenes,': [2097], 'S.': [2098, 2101, 2874, 3841], 'mutans': [2099], 'pneumoniae)': [2102], 'All': [2105], 'these': [2107, 2687, 4235, 4502, 4568, 5131, 5272, 5300], 'Bacillus/Clostridium': [2112], 'subdivision': [2113], 'bacteria,': [2117, 5203], 'specialized': [2123], "'niche'": [2124], 'where': [2125, 3218, 3769, 4013, 4127, 4377, 4397, 4836, 4856], 'thrives.': [2131], 'note,': [2136], 'despite': [2139, 3007, 3281], 'many': [2142, 4317, 5044], 'relatively': [2148, 4828], 'low': [2149], '(25–40%': [2153], 'identity)': [2154], 'when': [2158, 2637, 2751, 3037, 4061], 'compared': [2159, 3728], 'conserved': [2162, 2236, 3413, 4537], 'RecA.': [2166], 'Numerous': [2167], 'data,': [2168], 'biochemical,': [2172], 'demonstrate': [2174], 'How-ever,': [2195], 'inspection': [2196], 'sequenced': [2200, 4475], 'genome': [2203, 4731, 4846, 5177], 'reveals': [2204, 2678], 'presence': [2206, 2247, 3593, 3886, 4096, 4247, 4347], '(encoded': [2217, 2281, 2291], 'yrrC).': [2221], 'gene,': [2223, 4110, 4227], 'located': [2224], '1': [2227], 'megabase': [2228], 'away': [2229], 'addAB': [2232], 'operon,': [2233], 'D.': [2241], 'Ehrlich,': [2242], 'personal': [2243], 'communication).': [2244], 'might': [2251, 4084, 4352], 'appears': [2256, 4329, 5240], 'even': [2265, 3581, 5191], 'devoid': [2271], 'counterparts,': [2276], 'Deinococcus': [2279, 4493], 'radiodurans': [2280], 'DR1902)': [2285], 'archaeon': [2288], 'Methanococcus': [2289], 'jannaschii': [2290], 'MJ1519).': [2295], 'To': [2296, 3818], 'date,': [2297, 3819], 'therefore': [2300, 3327, 4328, 4824, 5239], 'unclear': [2301], 'whether': [2302, 2311, 4546, 4579], 'yrrC': [2303], 'encodes': [2304], 'bona': [2306], 'fide': [2307], 'product': [2314], 'aspect': [2320], 'metabolism.': [2323], 'there': [2336, 4452], 'regarding': [2340], 'metabolism': [2350], '[for': [2351], 'convenience,': [2352], 'originally': [2364], 'designated': [2365], 'RexAB': [2366], 'exonuclease)': [2369], '(El': [2370, 2771, 2789, 3016, 4732, 5233], 'Karoui': [2371, 2428, 2492, 2727, 2772, 2790, 3017, 4733, 5234], 'generic': [2381], 'sense': [2382], 'AddAB].': [2384], 'inactivation': [2392], 'leads': [2397], 'increased': [2399], 'sensitivity': [2400, 2483], 'treatments,': [2403], 'lower': [2404], 'viability': [2405], 'reduced': [2407], 'frequencies': [2408], 'measured': [2413], 'transduction': [2416], 'conjugation': [2418], '(Alonso': [2419, 2456, 3986], 'El': [2427, 2491, 2726], 'phenotypes': [2433], 'mimic': [2435], 'observed': [2437], 'recBCD–': [2441, 2756], 'cells.': [2442], 'defines': [2447], 'pathways': [2452], '1993).': [2460], 'Interestingly,': [2461], 'expression': [2462], 'allows': [2473, 3596, 5019], 'nearly': [2474, 2923], 'full': [2475, 3208], 'complementation': [2476], 'recBC–': [2479], 'strain': [2480, 4269], '1998),': [2495, 2793], 'establishing': [2496], 'performing': [2503], 'largely': [2504], 'overlapping': [2505], 'no': [2509, 4460, 4841], 'host-specific': [2511], 'factors': [2512], 'required': [2514, 4122, 4233], 'function.': [2517], 'Using': [2518], 'designed': [2531], 'maintain': [2535], 'integrity': [2537], 'information,': [2541], 'way.': [2551], 'As': [2552], 'above,': [2554], 'recognizes': [2560], 'responds': [2562], '8': [2566], 'bp': [2567, 2692, 2697, 2980], 'transforms': [2576], 'recombinogenic': [2586, 5311], 'attenuating': [2590], 'changing': [2592], 'polarity': [2594], 'degradation.': [2597], 'Several': [2598], 'independent': [2599], 'lines': [2600], 'argue': [2603], 'convincingly': [2604], 'possess': [2612, 4511], 'actual': [2618], '(they': [2625], 'χBs': [2631, 2694, 2964, 3070], 'χLl': [2633, 2739, 2769, 2781], 'dsDNA,': [2640], 'mediated': [2646], '(Dabert': [2656, 4816], 'Biswas': [2660], '1995;': [2663, 4197, 4427, 4756, 5101], 'Chédin': [2664, 2722, 2872, 3839], 'Analysis': [2668], 'composition': [2671], 'distribution': [2673], 'respective': [2676, 4730, 5212], 'genomes': [2677, 4476, 4515, 5219], 'additional': [2680, 4346], 'similarities': [2681], 'sequence:': [2686], '(5': [2691], '7': [2696], 'χLl;': [2699], 'Table': [2700], '1),': [2701], 'rich': [2703], 'G': [2705], 'residues,': [2706], 'over-represented': [2709, 4727, 5216], 'preferentially': [2711], 'co-oriented': [2712, 5229], 'respect': [2714], '(Tracy': [2718], 'obtained': [2741, 3256], 'lactis:': [2746], 'AddAB,': [2750], 'expressed': [2752], 'cells,': [2757], 'promotes': [2758], 'unless': [2763], 'lactococcal': [2768], 'site': [2770, 2803], 'shown': [2779, 2949, 3175], 'actually': [2782, 3764, 4806], 'AddAB-dependent': [2786], 'hot-spot': [2788], 'completing': [2795], 'analogy': [2797], 'original': [2800], 'counterpart.': [2806], 'studied': [2822], 'detail': [2824], 'vitro,': [2832], 'hallmarks': [2842], 'enzyme:': [2846], 'powerful': [2851], 'ATPase': [2862], '1996c;': [2866], 'F.': [2871], 'C.': [2875, 3842], 'unpublished': [2877, 3844], 'observations).': [2878, 3845], 'An': [2879, 4202], 'distinction': [2881], 'preference': [2902], "enzyme's": [2909, 3445, 5163], 'entry': [2910, 3446], 'point': [2911, 3447], '1993),': [2915], 'symmetrical': [2924], 'consistent': [2935], 'fact': [2938, 3279, 3718], 'contains': [2943, 2957], 'domains,': [2947], 'Fig.': [2951], '4,': [2952], 'one.': [2959], 'Interaction': [2960], 'occurs': [2970, 3039, 3064, 5080], 'orientation;': [2973], 'must': [2976, 4176], 'approach': [2977], '5': [2979], '5′-AGCGG-3′': [2982], 'side': [2986], '(as': [2987], 'here)': [2989], 'orientation': [2999], 'specificity': [3000, 3015], 'initial': [3008], 'reports': [3009], 'documenting': [3010], 'lack': [3012], 'orien-tation': [3014], '2000)': [3020], 'agreement': [3024], '(under': [3040], 'optimal': [3041, 3880], 'conditions,': [3042, 4149, 4165], '30%': [3043], 'time),': [3046], '3′–5′': [3049], 'completely': [3053, 3380], 'attenuated,': [3054], '5′–3′': [3057], 'unaffected.': [3061], 'attenuation': [3063, 3094], 'precisely': [3065, 3237], 'nucleotide': [3067], 'irrespective': [3072], 'strength': [3075], 'χBs,': [3081], 'suggests': [3083, 3610], 'specific.': [3090], 'occurred,': [3096], 'resumes.': [3098], 'behaves': [3103], 'solely': [3104], 'nuclease,': [3110], 'allowing': [3112], 'formation': [3115, 4640], 'overhang,': [3121], 'type': [3123, 5264], 'intermediate': [3125], 'domains.': [3145], 'A.': [3146], 'Alignment': [3147, 3191, 3241], 'domains': [3161, 3197, 3217], 'asterisks': [3168], 'residues': [3172, 3220], 'Wang': [3186], 'Red': [3206], 'indicates': [3207, 3211, 3225], 'conservation,': [3209], 'blue': [3210], 'conservative': [3212], 'substitutions.': [3213], 'boxes': [3215], 'tend': [3221], 'cluster.': [3223], 'nd': [3224], 'exact': [3228], 'co-ordinate': [3229], 'leftmost': [3232], 'residue': [3233], '(sequencing': [3238], 'progress).': [3240], 'consensus': [3243], 'building': [3244], 'using': [3248, 3344, 3914], 'CLUSTALW': [3250], 'program.': [3251], 'Preliminary': [3252], 'data': [3254, 5273], 'Institute': [3259], 'Genomic': [3261], 'Research': [3262], 'website': [3263], 'http://www.tigr.org.': [3265], 'striking': [3268], 'difference': [3269], 'that,': [3280], 'similar': [3283], 'properties,': [3285], 'composition.': [3294], 'subunit,': [3297, 3309, 3332, 3337], 'homology,': [3301], 'can,': [3311], 'itself,': [3313], 'translocate': [3314, 3461], 'along': [3315, 3353], 'displace': [3318], 'oligonucleotides': [3320], '(Phillips': [3321, 3468, 3587], 'hence,': [3334], 'complex,': [3343], 'derived': [3347], 'ATP': [3349, 3378], 'hydrolysis': [3350], 'move': [3352], '(Boehmer': [3360], '1992).': [3363, 3905], 'Correspondingly,': [3364], 'mutants': [3365], 'cannot': [3374], 'hydrolyse': [3377], 'defective': [3381], '(Hsieh': [3385], 'Julin,': [3387], 'Haijema': [3389], '1996d).': [3392], 'Knowing': [3393], 'degrades': [3398], 'domain,': [3415], 'tempting': [3418], 'speculate': [3420], 'being': [3425, 4137, 5246], 'specifically': [3426], 'degraded': [3427, 4178], 'subunit.': [3430], 'cross-links': [3438], '(Ganesan': [3448], 'Farah': [3452], '1997)': [3455], 'direction': [3467, 5184], '2000),': [3475], 'likely': [3478, 5196], 'degradation,': [3490], 'switched': [3496], 'off': [3497, 4608, 5024], 'χ.': [3501, 3529], 'AddB,': [3502], 'hand,': [3506], 'proposed': [3508], 'degrade': [3510, 4277], 'strand,': [3513], 'polarity;': [3519], 'From': [3530], 'analogy,': [3532], 'follows': [3534], 'probably': [3539, 3551], 'incorporates': [3540], 'subunits.': [3549], 'stimulation': [3553, 3566], 'manner': [3563], 'analogous': [3564], 'weak': [3569], 'further,': [3582], 'Finally,': [3591], 'recognize': [3600], '(involved': [3624, 3636], 'recognition;': [3627], 'Arnold': [3628], 'regulatory': [3639, 4048, 4603, 4704, 5017, 5052], 'response': [3640, 5316], 'χ;': [3642], 'Precisely': [3647], 'how': [3648], 'presently': [3665, 4477], 'unknown.': [3666], 'One': [3667, 4032, 4079, 4710], 'χ-containing,': [3688], '1997b),': [3694], '(Churchill': [3705], 'significance': [3710], 'phenomenon': [3714], 'pertains': [3715], 'disadvantage': [3727], 'SSB': [3731, 3788], 'Thus,': [3737], 'systems': [3738, 3763, 3926, 4619], 'reverse': [3740], 'competition': [3742], 'favour': [3744], 'evolved': [3749, 4618], 'play': [3751, 3964, 4018], 'Such': [3761], 'alternative': [3762], 'they': [3770, 4014, 4745], 'involve': [3771, 4859], 'RecF,': [3773, 3930], 'RecO': [3774], 'RecR': [3776, 4525], 'allow': [3780], 'compete': [3784], 'better': [3785], 'limit': [3795], 'extension': [3797], 'appropriate': [3804, 4073], '(Umezu': [3806], 'Umezu': [3810], 'Kolodner,': [3812], 'Webb': [3814], 'demonstrated': [3832], 'system': [3837, 4770, 4896, 4908, 4945], '(F.': [3838], 'heterologous': [3848], 'instead': [3862], 'intraspecies': [3866], 'combination,': [3867], 'could': [3869, 3921, 4066, 4151, 4738], 'affected': [3871], 'final': [3873], 'result.': [3874], 'indeed': [3877, 4261, 4910], 'levels': [3881], 'require': [3884], '(Rinken': [3897], '1991;': [3900], 'de': [3901, 4962], 'Vries': [3902], 'Wackernagel,': [3904], 'If': [3906], 'negative': [3908], 'result': [3909, 4272, 4412], 'suggest': [3923], '(such': [3927], 'O': [3931], 'R': [3933], 'proteins)': [3934], 'provide': [3935, 4739, 5252], 'essential': [3937], 'RecA-loading': [3938], 'regard,': [3945], 'note': [3950, 4450], 'RecF': [3953, 4523, 4530], 'exists': [3956], 'prominent': [3968], 'organism,': [3972], 'judged': [3974], 'analysis': [3976], 'impaired': [3979], 'recF': [3982], 'recO': [3984], 'Fernandez': [3991], 'Regulated': [3995], 'helicases/exonucleases': [3996], 'seen': [4007], 'widespread': [4010], 'Eubacteria,': [4012], 'expected': [4016], 'recombination-dependent': [4029], 'replication.': [4031], 'wonder,': [4034], 'why': [4036], 'solution,': [4038], 'voracious': [4042, 4610], 'much-needed': [4047], 'switch': [4049, 5023, 5053], "'domesticate'": [4051], '(Myers': [4053], '1994),': [4056], 'so': [4059], 'successful': [4060], 'other,': [4062], 'seemingly': [4063], 'easier,': [4064], 'routes': [4065], 'create': [4071], 'substrates': [4074, 4832], 'answer': [4080], 'puzzle': [4083], 'stem': [4085], 'evolutionary': [4088], 'advantage': [4089], 'conferred': [4090], 'recD': [4109, 4226], 'hence': [4112], 'RecBCD,': [4119], 'survival': [4124], 'under': [4125, 4162, 4234], 'conditions': [4126, 4238], 'unrepairable': [4132], 'generated': [4138], '(Michel': [4139], 'Seigneur': [4143], 'Under': [4147], 'saturation': [4155], 'machinery': [4159], 'growth': [4161, 4237, 4365], 'extremely': [4163], 'adverse': [4164], 'otherwise': [4167, 4371], 'recA–': [4170], 'background,': [4172], 'broken': [4173], 'chromosome': [4174], 'arms': [4175], 'if': [4185, 4567, 4925], 'survive': [4189], '(Skarstad': [4190], 'Boye,': [4192], 'Uzest': [4194], 'Kuzminov': [4198], 'illustration': [4203], 'Photobacterium': [4209], 'profundum,': [4210], 'marine': [4212], 'whose': [4214], 'grow': [4217], 'elevated': [4219], 'pressure': [4220], 'strictly': [4222], 'dependent': [4223], 'indicating': [4228], 'extreme': [4236], '(Bidle': [4239], 'Bartlett,': [4241], 'benefit': [4244], 'prevention': [4252], 'diverged': [4257], 'sequences.': [4258], 'increases': [4262], '100-': [4263], '1000-fold': [4265], 'recD–': [4268], 'failure': [4275], 'aberrant,': [4278], 'mismatch-containing,': [4279], 'intermediates': [4281], '(Zahrt': [4282], 'Maloy,': [4284], 'Stambuk': [4286], 'Radman,': [4288, 4931], 'commonly': [4293], 'defence': [4300, 4769], 'against': [4301], 'intruding': [4302], 'linear': [4303], '(Russel': [4306], '1989),': [4309], 'worth': [4313, 4763], 'mentioning': [4314], 'cases': [4318, 4455, 4835], 'protection': [4320, 4866], 'far': [4322], 'perfect': [4324], 'cope': [4357, 5259], 'demands': [4360], 'associated': [4361, 4570, 5157], 'fast': [4364], 'rate': [4366], 'adapt': [4369, 4562], 'hostile': [4372], 'environments,': [4373, 4565], 'ones': [4376], 'amounts': [4379], 'produced.': [4385], 'prediction': [4387], 'may': [4388], 'turn': [4389, 4607], 'Salmonella': [4395], 'typhimurium,': [4396], 'lose': [4402], 'virulence': [4404], 'animals': [4406], 'tissue': [4408], 'culture': [4409], 'inability': [4415], 'resist': [4417], 'oxidative': [4419], 'burst': [4420], 'macrophages': [4422], '(Buchmeier': [4423], '1993,': [4426], 'Spek': [4428], 'well-known': [4433], 'source': [4434], '(Schlosser-Silverman': [4439], 'light,': [4445], 'numerous': [4454], 'detected.': [4471], 'Among': [4472], 'fully': [4474], 'available,': [4478], 'situation': [4480], 'applies': [4481], 'Aquifex': [4483], 'aeolicus,': [4484], 'Helicobacter': [4485], 'pylori,': [4486], 'Mycoplasma': [4487, 4489], 'genitalium,': [4488], 'pneumoniae,': [4490], 'Rickettsia': [4491], 'prowazekii,': [4492], 'radiodurans,': [4494], 'Synechocystis': [4495], 'Treponema': [4497], 'pallidum.': [4498], '(with': [4504], 'exception': [4506], 'myco-plasmas': [4509], 'smallest': [4513], 'date)': [4518], 'suggesting': [4527], 'evolution.': [4539], 'would': [4541], 'document': [4545], 'deprived': [4549], 'limited': [4557], 'new': [4564, 5325], 'especially': [4566], 'high': [4573, 5115], 'incidence': [4574], 'damage,': [4577], 'handicap': [4581], 'compensated': [4583], 'higher': [4586], 'mutability.': [4587], 'For': [4588], 'contain': [4591], 'homologue,': [4597], 'need': [4600], 'circuit': [4604], 'obvious.': [4614], 'Some': [4615], 'bacteriophages': [4616, 5003], 'do': [4621], 'just': [4622], 'that.': [4623], 'ends': [4625, 5119], 'N15': [4630], 'protected': [4633], 'covalently': [4643], 'closed': [4644], 'hairpin': [4645], 'structure': [4646], '(Rybchin': [4647], 'Svarchevsky,': [4649], '1999),': [4650, 4736], 'whereas': [4651], 'T4': [4653], 'makes': [4655, 5188], 'end-capping': [4659], '2': [4661], '(Oliver': [4663], 'Goldberg,': [4665], '1977).': [4666], 'utilizes': [4670], 'Gam': [4672], 'protein,': [4673], 'inhibits': [4676], '(Murphy,': [4681, 4697], '1991),': [4682], 'P22': [4685], 'modifies,': [4687], 'advantage,': [4690], 'instead,': [4700], 'make': [4701], 'argument': [4711], 'frequently': [4712], 'put': [4713], 'forward': [4714], 'rationalize': [4716, 5154], 'choice': [4718], "'password'": [4721, 4821], 'paradigm.': [4722], 'usually': [4726], 'hosts': [4741], 'password': [4744], 'discriminate': [4749], 'self': [4750], 'non-self': [4752], 'Cheng': [4757], '1984).': [4760], 'mentioning,': [4764], 'χ-based': [4768], 'shortcomings:': [4773], 'piece': [4779], 'foreign': [4781, 4830], "host's": [4785], 'targeted': [4792], 'incorporated': [4798], 'genome,': [4801], 'property': [4803], 'achieve': [4810], 'replacement': [4812], 'operate': [4826], 'incoming': [4838], 'locus': [4843], 'receiving': [4849], 'bacterium.': [4850], 'case': [4853, 4877, 4970], 'conjugation,': [4855, 4881], 'exchanges': [4857], 'up': [4860], 'megabases': [4862], 'will,': [4870], 'likely,': [4872], 'ineffective.': [4874], 'attempted': [4879], 'interspecies': [4880], 'enforcer': [4884], "'purity'": [4887], 'methyl-directed': [4893], 'mismatch': [4894, 4943], '(Rayssiguier': [4897], 'Matic': [4901], '1995).': [4904, 4966], 'MutHLS': [4907], 'edit': [4911], 'heteroduplex': [4912], 'promote': [4919], 'reversal': [4921], 'destruction': [4924], 'mismatches': [4926], '(Stambuk': [4929], 'evolution,': [4940], 'since': [4941], 'serves': [4947], 'prevent': [4949], 'slightly': [4953], 'divergent': [4954], 'eukaryotes': [4957], '(Chen': [4958], 'Jinks-Robertson,': [4960], 'Wind': [4963], 'compelling': [4969], 'provided': [4993], 'While': [4997], 'stratagems': [5000], 'aim': [5004], 'permanently': [5006], 'disabling': [5007], 'switching': [5029], 'repeated': [5042], 'times': [5045], 'necessary.': [5047], 'usefulness': [5049], 'underlined': [5056], 'spontaneous': [5064], 'Contrary': [5070], 'popular': [5072], 'belief,': [5073], 'cycle': [5084], 'consequence': [5087], 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