HISTOLOGICAL AND CLINICAL FINDINGS IN 896 CONSECUTIVE PROSTATES TREATED ONLY WITH RADICAL RETROPUBIC PROSTATECTOMY: EPIDEMIOLOGIC SIGNIFICANCE OF ANNUAL CHANGES

Name: Work Video:
Duration: 3 min 30 s
Thomas A. Stamey; Nora Donaldson; Cheryl Yemoto; John E. McNeal; Sinan Sözen; Harcharan Gill
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'dichotomous': [172], 'variables': [173], 'linear': [176], 'continuous': [179], 'variables,': [180], 'both': [181], 'corrected': [182], 'age,': [184], 'assessed': [186], 'significant': [191, 251, 421], 'changes': [192, 253, 278], 'versus': [195], 'T2': [196, 378, 1006, 1187], 'stages,': [198], 'preoperative': [199], 'serum': [200, 263, 408, 672], 'specific': [202, 508, 674, 807], 'antigen': [203, 509, 675, 764, 785, 808], '(PSA),': [204], 'volume,': [206, 402], 'percent': [207, 258, 403], 'Gleason': [208, 259, 404, 910], 'grade': [209, 260, 405], '4/5': [210, 261, 406], 'cancer,': [213, 262, 407], 'location': [214], 'transition': [220, 312], 'or': [221, 267], 'peripheral': [222], 'zone,': [223], 'organ': [224, 301], 'confined': [225, 302], 'status,': [226], 'seminal': [227], 'vesicle': [228, 323], 'invasion,': [229], 'positive': [230, 334], 'surgical': [231, 335], 'margins,': [232], 'weight': [234, 266], 'presence': [236], 'clinically': [238, 268, 443], 'insignificant': [239, 269, 444], 'cancers': [240, 270, 288, 303, 314, 379, 388, 395, 411], '(less': [241], 'than': [242, 272, 413], '0.5': [243, 273, 414], 'cc': [244, 415], 'volume).': [246], 'Results:': [247], 'There': [248], 'no': [250], 'proportion': [256], 'PSA,': [264], 'less': [271, 412], 'cc,': [274], 'volume': [281, 594, 618], 'moderate': [285], 'significance.': [286], 'increased': [289], '10%': [291], '73%': [295], '(p': [298, 308, 319, 330, 341, 353], '=': [299, 309, 320, 331, 342, 354], '0.0001),': [300], '40': [305], '75%': [307], '0.0001)': [310], 'zone': [313], '10': [316, 699], '21%': [318], '0.003).': [321], 'Seminal': [322], 'invasion': [324], 'decreased': [325], '18': [327], '5%': [329], '0.001)': [332], 'margins': [336], '30': [338], '14': [340, 804], '0.006).': [343], 'Mean': [344], 'patient': [345], 'age': [346], 'changed': [347], '65': [349], '62': [351], 'years': [352], '0.0001).': [355], 'Conclusions:': [356], 'We': [357], 'believe': [358], 'extraordinary': [361], 'rise': [362], 'fall': [364, 460, 495], 'detection': [368, 441, 679, 828], 'rates': [369], '1990': [371], '1994': [373], 'primarily': [374], 'removed': [375], 'previously': [376], 'undetected': [377], 'pool': [382], 'at': [383], 'large,': [384], 'leaving': [385], 'impalpable': [386], 'as': [389, 770, 786, 809], 'primary': [391], 'reservoir': [392], 'United': [398], 'States.': [399], 'Importantly,': [400], 'PSA': [409, 434, 448, 473, 532], 'have': [416], 'not': [417, 437, 454], 'had': [418], 'a': [419, 472, 506, 685, 704, 771, 810, 875], 'highly': [420], 'change': [422], 'during': [423], 'these': [424], 'critical': [425], '9': [426, 664, 1069], 'years.': [427], 'These': [428], 'data': [429, 534], 'argue': [430], 'strongly': [431], 'current': [433], 'testing': [435], 'resulted': [438], 'cancers,': [445], 'screening': [449], 'should': [450], 'be': [451], 'expanded': [452], 'restricted.': [455], 'References': [456], ':': [458, 493, 525, 546, 569, 590, 611, 633, 665, 700, 727, 750, 783, 805, 826, 841], 'The': [459, 494, 728], 'incidence': [462, 497], '(CaP):': [466], 'on': [467, 501, 641, 752], 'down': [469, 503], 'side': [470, 504], 'detection/screening': [474], 'induced': [475, 510], 'peak': [476, 511], 'incidence-data': [478, 513], 'Utah': [481, 516], 'Tumor': [482, 949], 'Registry.': [483, 518], 'J.': [484, 561, 582, 657, 692, 719, 742, 796, 819, 846], 'Urol.1995;': [485], '153:': [486], '416A.': [487], 'abstract': [488], '752.': [489], 'Google': [490, 522, 543, 566, 587, 608, 630, 662, 697, 724, 747, 780, 802, 823, 838, 852], 'Scholar': [491, 523, 544, 567, 588, 609, 631, 663, 698, 725, 748, 781, 803, 824, 839, 853], '2': [492, 1048, 1067], 'carcinoma:': [500], 'Cancer': [517, 798, 848, 916], 'Cancer1995;': [519], '77:': [520], '1342.': [521], 'Population-based': [526], 'era:': [533], 'SEER': [537], 'program.': [538], 'Monogr.': [539], 'Urol.1998;': [540, 658], '19:': [541], '1.': [542], '4': [545, 914], 'Zonal': [547], 'distribution': [548], 'prostatic': [550], 'adenocarcinoma:': [551], 'correlation': [552], 'histologic': [554], 'pattern': [555], 'direction': [557], 'spread.': [559], 'Amer.': [560, 581], 'Surg.': [562, 583], 'Path.1988;': [563], '12:': [564], '897.': [565], '5': [568], 'Capsular': [570], 'penetration': [571], 'cancer:': [574, 682, 758, 831], 'significance': [575, 621], 'natural': [577], 'history': [578], 'treatment.': [580], 'Path.1990;': [584], '14:': [585], '240.': [586], '6': [589, 1240], 'Histologic': [591], 'differentiation,': [592], 'pelvic': [596], 'lymph': [597], 'node': [598], 'metastasis': [599], 'adenocarcinoma': [601], 'prostate.': [604], 'Cancer1990;': [605], '66:': [606], '1225.': [607], '7': [610], 'Localized': [612], 'cancer.': [614, 626], 'Relationship': [615], 'tumor': [617], 'treatment': [623], 'Cancer1993;': [627, 777], '71:': [628, 778], '933.': [629], '8': [632], 'Classification': [634], 'localized': [636], 'untreated': [637, 768], 'based': [640], '791': [642], 'prostatectomy:': [648], 'common': [649], 'ground': [650], 'therapeutic': [652], 'trials': [653], 'TNM': [655], 'subgroups.': [656], '159:': [659], '2009.': [660], 'Link,': [661, 746], 'Comparison': [666], 'digital': [668, 815], 'rectal': [669, 816], 'examination': [670], 'early': [678], 'results': [683], 'multicenter': [686], 'trial': [688], '6,630': [690], 'men.': [691, 795], 'Urol.1994;': [693, 820], '151:': [694], '1283.': [695], 'Abstract,': [696, 723], 'Has': [701], 'there': [702], 'been': [703], 'recent': [705], 'shift': [706], 'pathological': [709], 'features': [710], 'prognosis': [712], 'patients': [714, 766], 'prostatectomy?': [718], 'Urol.1997;': [720], '157:': [721], '2212.': [722], '11': [726], 'frequency': [729], 'carcinoma': [731], 'intraepithelial': [733], 'neoplasia': [734], 'young': [739], 'male': [740], 'patients.': [741], 'Urol.1993;': [743], '150:': [744], '379.': [745], '12': [749], 'Observations': [751], 'doubling': [754], 'time': [755], 'use': [760], 'serial': [762], 'prostate-specific': [763], 'disease': [769], 'measure': [772], 'increasing': [774], 'volume.': [776], '2031.': [779], '13': [782], 'Prostate-specific': [784], 'predictor': [787, 811], 'black': [792], 'white': [794], 'Natl.': [797, 847], 'Inst.1995;': [799], '87:': [800], '354.': [801], 'Prostate': [806, 915, 956, 1007], 'an': [813], 'abnormal': [814], 'examination.': [817], 'Brit.': [818], '74:': [821], '337.': [822], '15': [825], 'Early': [827], 'serendipity': [832], 'strikes': [833], 'again.': [834], 'J.A.M.A.1997;': [835], '278:': [836], '1516.': [837], '16': [840], 'Age-adjusted.': [842], 'U.S.cancer': [843], 'death': [844], 'rates.': [845], 'Inst.1997;': [849], '89:': [850], '12.': [851], 'From': [854], 'Department': [856, 862, 883], 'Urology,': [858, 885, 922, 969, 1020, 1072, 1108, 1143, 1190, 1228], 'School': [859], 'Medicine,': [861], 'Statistics,': [864], 'Stanford': [865, 887], 'University,': [866, 871], 'Stanford,': [867, 894], 'California,': [868], 'Gazi': [870], 'Ankara,': [872], 'TurkeySupported': [873], 'grant': [876], 'Lucas': [879], 'Foundation.Requests': [880], 'reprints:': [882], 'S-287,': [886], 'University': [888], 'Medical': [889], 'Center,': [890], '300': [891], 'Pasteur': [892], 'Drive,': [893], 'California': [895], '94305.©': [896], '1998': [897, 1249], 'American': [899, 1251], 'Urological': [900, 1252], 'Association,': [901, 1253], 'Inc.FiguresReferencesRelatedDetailsCited': [902], 'byLavery': [903], 'H': [904], 'Droller': [906], 'M': [907, 945], '(2018)': [908, 946, 995, 1040, 1090, 1128, 1167, 1204], 'Do': [909], 'Patterns': [911], 'Represent': [917], 'Separate': [918], 'Disease': [919], 'States?Journal': [920], 'VOL.': [923, 970, 1021, 1073, 1109, 1144, 1191, 1229], '188,': [924], 'NO.': [925, 972, 1023, 1075, 1111, 1146, 1193, 1231], '5,': [926, 1194], '(1667-1675),': [927], 'Online': [928, 975, 1026, 1078, 1114, 1149, 1196, 1234], 'publication': [929, 976, 1027, 1079, 1115, 1150, 1197, 1235], 'date:': [930, 977, 1028, 1080, 1116, 1151, 1198, 1236], '1-Nov-2012.Magheli': [931], 'A,': [932, 1120], 'Rais-Bahrami': [933], 'S,': [934, 989, 1122], 'Peck': [935], 'H,': [936], 'Walsh': [937], 'P,': [938, 1159], 'Epstein': [939], 'J,': [940, 1034], 'Trock': [941], 'B': [942], 'Gonzalgo': [944], 'Importance': [947], 'Location': [950], 'Patients': [952], 'With': [953, 965], 'High': [954], 'Preoperative': [955], 'Specific': [957], 'Antigen': [958], 'Levels': [959], '(Greater': [960], 'Than': [961], '20': [962], 'ng/ml)': [963], 'Treated': [964], 'Radical': [966, 999], 'ProstatectomyJournal': [967], '178,': [971], '4,': [973], '(1311-1315),': [974], '1-Oct-2007.Jack': [978], 'G,': [979], 'Cookson': [980], 'M,': [981, 1118], 'Coffey': [982], 'C,': [983], 'Vader': [984], 'V,': [985], 'Roberts': [986], 'R,': [987, 1153], 'Chang': [988], 'Smith': [990], 'J': [991, 1089, 1124, 1163], 'Shappell': [993], 'S': [994], 'Pathological': [996, 1010], 'Parameters': [997], 'Prostatectomy': [1000], 'Clinical': [1002], 'Stages': [1003], 'Versus': [1005], 'Adenocarcinoma:': [1008], 'Decreased': [1009], 'Stage': [1011], 'Increased': [1013], 'Detection': [1014], 'Transition': [1016], 'Zone': [1017], 'TumorsJournal': [1018], '168,': [1022], '2,': [1024, 1147], '(519-524),': [1025], '1-Aug-2002.STAMEY': [1029], 'T,': [1030, 1082], 'JOHNSTONE': [1031], 'I,': [1032], 'LU': [1035], 'A': [1036, 1100], 'C': [1039, 1203], 'PREOPERATIVE': [1041], 'SERUM': [1042, 1212], 'PROSTATE': [1043, 1059, 1098, 1140, 1174, 1213], 'SPECIFIC': [1044, 1060, 1130, 1214], 'ANTIGEN': [1045, 1061, 1215], 'LEVELS': [1046], 'BETWEEN': [1047, 1066], '22': [1050], 'NG./ML.': [1051], 'CORRELATE': [1052], 'POORLY': [1053], 'POST-RADICAL': [1055], 'PROSTATECTOMY': [1056, 1136], 'CANCER': [1057], 'MORPHOLOGY:': [1058], 'CURE': [1062], 'RATES': [1063], 'APPEAR': [1064], 'CONSTANT': [1065], 'NG./ML.Journal': [1070], '167,': [1074], '1,': [1076, 1232], '(103-111),': [1077], '1-Jan-2002.CHAN': [1081], 'CHAN': [1083], 'D,': [1084, 1157], 'STUTZMAN': [1085], 'K': [1086], 'EPSTEIN': [1088, 1123], 'DOES': [1091], 'INCREASED': [1092], 'NEEDLE': [1093], 'BIOPSY': [1094], 'SAMPLING': [1095], 'THE': [1097, 1173, 1207], 'DETECT': [1099], 'HIGHER': [1101], 'NUMBER': [1102], 'POTENTIALLY': [1104], 'INSIGNIFICANT': [1105], 'TUMORS?Journal': [1106], '166,': [1110, 1145], '6,': [1112], '(2181-2184),': [1113], '1-Dec-2001.HAN': [1117], 'PARTIN': [1119], 'PIANTADOSI': [1121], 'WALSH': [1126], 'P': [1127], 'ERA': [1129], 'BIOCHEMICAL': [1131], 'RECURRENCE-FREE': [1132], 'SURVIVAL': [1133], 'FOLLOWING': [1134], 'FOR': [1137, 1216], 'CLINICALLY': [1138], 'LOCALIZED': [1139], 'CANCERJournal': [1141], '(416-419),': [1148], '1-Aug-2001.TIGUERT': [1152], 'GHEILER': [1154], 'E,': [1155], 'GRIGNON': [1156], 'LITTRUP': [1158], 'SAKR': [1160], 'W,': [1161], 'PONTES': [1162], 'WOOD': [1165], 'D': [1166], 'PATIENTS': [1168], 'ABNORMAL': [1170], 'ULTRASOUND': [1171], 'BUT': [1175], 'NORMAL': [1176], 'DIGITAL': [1177], 'RECTAL': [1178], 'EXAMINATION': [1179, 1205], 'SHOULD': [1180], 'BE': [1181], 'CLASSIFIED': 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