Publication Information

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3074], 'Italian': [15, 50, 1021, 1519], 'Patients': [16, 51, 1068, 2346], 'With': [17, 52, 1069, 2977], 'a': [18, 53, 219, 244, 276, 296, 309, 343, 355, 377, 399, 409, 416, 492, 659, 765, 816, 826, 897, 916, 949, 1070, 1150, 1277, 1317, 1326, 1531, 1542, 1569, 1633, 1637, 1680, 1746, 1768, 1895, 1906, 1932, 1941, 1951, 1965, 1971, 2022, 2053, 2068, 2106, 2135, 2235, 2280, 2602, 3034], 'History': [19, 54, 1071], 'Early-Onset': [21, 56, 1073], 'Ischemic': [22, 57, 1074, 3045], 'Stroke': [23, 58, 1075, 2401], 'Free': [24], 'AccessOtherPDF/EPUBAboutView': [25], 'PDFView': [26], 'EPUBSections': [27], 'ToolsAdd': [28], 'to': [29, 285, 339, 392, 429, 444, 450, 734, 746, 787, 812, 929, 995, 1049, 1510, 1545, 1557, 1622, 1762, 1868, 1893, 2124, 2159, 2194, 2207, 2222, 2233, 2237, 2242], 'favoritesDownload': [30], 'citationsTrack': [31], 'citationsPermissions': [32], 'ShareShare': [33], 'onFacebookTwitterLinked': [34], 'InMendeleyReddit': [35], 'Jump': [36], 'toFree': [37], 'AccessOtherPDF/EPUBHomozygous': [38], 'Lucia': [59, 76], 'Soriente,': [60], 'Antonio': [61, 91], 'Coppola,': [62], 'Pasquale': [63, 106], 'Madonna,': [64], 'Anna': [65, 121], 'Maria': [66, 122, 124], 'Cerbone': [67, 125], 'Giovanni': [69, 138], 'Di': [70, 139, 141, 1450], 'Minno': [71, 142, 1451], 'Guiseppe': [72, 154], 'Orefice': [73, 156], 'Armando': [74, 168], "D'Angelo": [75, 170, 1405, 1413, 1437], 'SorienteLucia': [77], 'Soriente': [78, 1661, 1901, 2018], 'Department': [79, 94, 109, 126, 143, 157], 'Clinical': [81, 96, 111, 128, 145, 2352, 2493, 2878], 'Experimental': [83, 98, 113, 130, 147], 'Medicine,': [84, 99, 114, 131, 148], 'University': [85, 100, 115, 132, 149, 161], 'Naples': [87, 102, 117, 134, 151, 163], 'Federico': [88, 103, 118, 135, 152, 164], 'II': [89, 104, 119, 136, 153], ',': [90, 105, 120, 582, 2288], 'CoppolaAntonio': [92], 'Coppola': [93], 'MadonnaPasquale': [107], 'Madonna': [108], 'CerboneAnna': [123], 'MinnoGiovanni': [140], 'OreficeGuiseppe': [155], 'Neurological': [159], 'Sciences,': [160, 2406, 2495], 'II,': [165], 'Naples,': [166], 'Italy': [167, 177], "D'AngeloArmando": [169], 'Coagulation': [171, 2460], 'Service,': [172], 'IRCCS': [173], 'H.S.': [174], 'Raffaele,': [175], 'Milan,': [176], 'Originally': [178, 3105], 'published1': [179], 'Apr': [180], '1998https://doi.org/10.1161/01.STR.29.4.869Stroke.': [181], '1998;29:869–871To': [182], 'Editor:': [184], 'Case-control12': [185], 'prospective34': [187], 'studies': [188, 1867], 'have': [189, 407, 992, 1884, 1890, 2052], 'suggested': [190], 'an': [191, 287, 986, 1175, 1518, 1665, 1683, 1728, 1842, 2125, 2169], 'association': [192, 263, 288, 800, 1000, 1641, 1666, 1805, 1873, 2078], 'between': [193, 289, 380, 843, 959, 1001, 1667, 1792, 1806, 1874, 1954, 2025], 'moderate': [194, 236, 1417], 'hyperhomocysteinemia': [195, 903, 964, 1418, 2316], 'risk': [197, 249, 1153, 1177, 1207, 1234, 1272, 1328, 1364, 1532, 1748, 1769, 1925, 2488, 2548], 'ischemic': [199, 315, 319, 420, 1006, 1209, 1396, 1737, 1887, 2320, 2479, 2550, 2588, 2655], 'stroke.': [200, 919, 1156, 1210, 1536, 1751], 'Homozygosity': [201], 'for': [202, 256, 301, 487, 550, 555, 1090, 1096, 1125, 1155, 1179, 1274, 1330, 1534, 1691, 1750, 1771, 1930, 2137, 2144], 'C-to-T': [204], 'substitution': [205], 'at': [206, 437, 1844, 1871, 1886, 1916], 'nucleotide': [207], '677': [208], 'gene': [211, 1324, 1465, 1495, 1527, 2077, 2267, 2314, 2545, 2599, 2620, 2650, 2903], '5,10-methylenetetrahydrofolate': [213, 1463], 'reductase': [214, 1323, 1358, 1392, 1464, 1493, 2263, 2544, 2649], '(MTHFR)': [215, 1494, 2942], 'is': [216, 229, 921, 1325, 1620, 1651, 1744, 1977, 2042, 2064, 2067, 2087], 'associated': [217, 776, 2653], 'with': [218, 268, 314, 342, 415, 569, 672, 777, 801, 858, 881, 889, 915, 936, 1025, 1039, 1085, 1421, 1574, 1578, 1653, 1736, 1773, 1776, 1778, 1918, 1940, 1964, 2075, 2270, 2342, 2347, 2590, 2597, 2654, 3076], '50%': [220], 'reduction': [221], 'activity': [224], 'this': [226, 265, 366, 752, 937, 966, 970, 1515, 1594, 1649, 1848, 2066], 'enzyme5': [227], 'most': [231, 1881], 'common': [232, 1278, 1318, 1387], 'inherited': [233], 'cause': [234], 'hyperhomocysteinemia.': [237], 'In': [238, 764, 853, 1674, 1800, 2104, 2232], '1996': [239], 'Klujitmans': [240, 1287], 'et': [241, 281, 739, 851, 871, 1662, 1902, 2019], 'al6': [242], 'reported': [243, 1008, 1027], 'threefold': [245], 'increase': [246, 1684], 'early-onset': [251, 419, 1422, 1535], 'cardiovascular': [252, 1331, 1879], 'disease': [253, 291, 1810], 'homozygotes': [255, 670, 711], 'MTHFR': [259, 294, 304, 381, 562, 590, 657, 772, 794, 823, 906, 946, 1062, 1526, 1694, 1742, 1876, 2028, 2049, 2265, 2313, 2390, 2592, 2662, 2982], 'mutation.': [260], 'However,': [261, 371, 940, 1010, 1920], 'genetic': [266, 1003, 1054, 1271, 1312, 1327], 'marker': [267, 1004], 'arterial': [269, 1425], 'vascular': [270, 1180, 1275, 1468], 'events': [271, 2778], 'has': [272], 'been': [273, 1928], 'disputed': [274], 'by': [275, 351, 456, 518, 524, 566, 707, 1028, 1642, 3101], 'nested': [277], 'case-control': [278], 'study.7': [279], 'Markus': [280, 738, 850, 870, 1374], 'al8': [282], 'recently': [283, 2127], 'failed': [284, 1892], 'show': [286, 1894, 1905, 2021], 'cerebrovascular': [290, 1397, 1809], 'genotype,': [295, 2029], 'comparable': [297, 1024], 'prevalence': [298, 586, 662, 1687, 1911], 'homozygosity': [300, 961], 'mutation': [305, 563, 591, 773, 795, 824, 907, 947, 977, 1279, 1319, 1461, 1489], 'being': [306, 388], 'detectable': [307], 'population': [310, 410, 547, 1520, 1698, 1988, 2041, 2093], '345': [312], 'patients': [313, 358, 414, 584, 620, 639, 653, 680, 724, 761, 880, 888, 1091, 1097, 1126, 1420, 1734, 1772, 1777, 1959, 1997, 2082], 'stroke': [316, 344, 421, 860, 1007, 1236, 1672, 1738, 1774, 1913, 2551, 2589, 2717], 'or': [317, 467, 1711, 2096], 'transient': [318], 'attacks': [320], '(TIA)': [321], '161': [324], 'control': [325, 361, 599, 627, 1117, 1819, 1836, 2092], 'subjects': [326, 341, 362, 485, 628, 914, 935, 1589, 1816, 1820, 1832], '(10.7%': [327], 'versus': [328, 712, 730, 1706, 1717, 1797], '13.7%,': [329], 'respectively).': [330], 'Nor': [331], 'were': [332, 476, 861, 891, 1508, 1539, 1552, 1563, 1586, 1824, 1962, 2083, 2101], 'nonfasting': [333, 924, 953, 1564, 1646], 'log': [334, 393, 1602], 'homocysteine': [335, 384, 502, 685, 926, 954, 1106, 1231, 1458, 1584, 1603, 1669, 2031, 2059, 2272, 2724], 'plasma': [336, 501, 684, 741, 755, 925, 1105, 1146, 1204, 1360, 1457, 2720, 2735], 'levels': [337, 686, 748, 756, 927, 1107, 1538, 1554, 1559, 1585, 1670, 2273, 2727], 'able': [338], 'identify': [340, 930], 'history': [345, 417, 493, 917], 'that': [347, 821, 886, 923, 1042, 1523, 1546, 1583, 1722, 2016, 2045, 2065], 'setting,': [348, 855], 'as': [349, 372, 483, 497, 534, 1149, 1852, 2209, 2486], 'judged': [350], 'analysis': [353, 819, 1313, 1761], 'subgroup': [356, 1570, 1760, 1995], '(n=160)': [359], '(n=75)': [363], 'whom': [365], 'amino': [367, 522], 'acid': [368, 523, 2037], 'was': [369, 516, 532, 564, 593, 602, 614, 635, 666, 719, 743, 774, 825, 873, 883, 1629, 1677, 1704, 1727, 1767, 1786, 1803, 1850, 1936, 2094, 2114], 'measured.': [370], 'expected,': [373], 'authors': [375], 'found': [376, 667, 1582, 2115], 'significant': [378, 804, 997, 2023], 'relationship': [379], 'genotype': [382, 1700, 1743, 1807, 1910, 2050, 2113], 'levels,': [385], 'latter': [387], 'also': [389, 1758, 1891], 'independently': [390], 'related': [391, 745], 'serum': [394, 1229, 2026, 2058, 2271], 'folate.In': [395], 'frame': [397], 'larger': [400], 'study': [401, 868, 901, 1202, 1227, 1516, 1549, 2014, 2099, 2282], 'on': [402, 1012, 1664, 2056, 2213, 2907], 'juvenile': [403, 859], 'thrombotic': [404, 1467, 2777], 'events,': [405], 'we': [406, 1560, 1581, 1757], 'evaluated': [408, 884], '60': [412, 619, 2081], 'consecutive': [413, 1732], '(29': [422], 'females': [423, 556], '31': [425], 'males,': [426], 'aged': [427, 1821, 1998], '5': [428], '64': [430], 'years': [431, 1854, 1859], '[mean': [432], 'age,': [433, 490], '38;': [434], 'mean': [435, 716, 864, 1104, 1966, 1983, 1991], 'age': [436, 865, 1967, 1973, 1984, 1992], 'time': [438], 'diagnosis,': [440], '34;': [441], 'range': [442], '4': [443, 695, 3094], '49': [445], 'years])': [446], 'documented': [447], 'within': [448, 544], '72': [449], '96': [451], 'hours': [452], 'from': [453, 465, 478, 796, 893, 1624, 1636], 'event': [455, 779], 'CT': [457, 1782], 'and/or': [458, 473], 'MRI': [459], 'scans.': [460], 'Subjects': [461], 'who': [462, 468], 'had': [463, 1927], 'suffered': [464], 'TIA': [466, 882, 890, 1779], 'exhibited': [469], 'abnormalities': [470], 'carotid': [472], 'vertebral': [474], 'arteries': [475], 'excluded': [477, 892], 'study.': [480, 895], 'As': [481, 577, 896, 1752], 'many': [482], '182': [484, 606, 626], 'matched': [486], 'sex': [488], 'without': [491], 'thrombosis,': [495], 'served': [496], 'controls.': [498, 763, 2120], 'Total': [499], 'fasting': [500, 612, 683, 717, 902, 963, 1553], '(tHcy),': [503], 'ie,': [504], 'sum': [506], 'free': [508], 'protein-bound': [510], 'forms': [511], 'plus': [512], 'cysteine-homocysteine': [513], 'mixed': [514], 'disulfide,': [515], 'measured': [517, 1540, 1630], 'isolation': [519], 'high-performance': [525], 'liquid': [526], 'chromatography': [527], 'fluorescence': [529], 'detection.9': [530], 'defined': [533], 'tHcy': [535, 613, 634, 665, 718, 742, 802, 830, 1066, 1102], 'values': [536], 'above': [537, 687, 1108], '95th': [539, 689, 1110], 'percentile': [540, 690, 1111], 'distribution': [543, 650, 1114], 'general': [546], '(>19.5': [548], 'μM': [549, 554, 637, 642, 729], 'males': [551], '>15': [553], 'our': [558, 854, 894, 900, 979, 1029, 1548, 1697, 1724, 1755, 1986, 1994, 2013], 'population).9': [559], 'The': [560, 956, 972, 1864, 1958, 2897, 2935], 'studied': [565, 1961], 'endonuclease': [567], 'digestion': [568], 'HinfI': [570], 'polymerase': [573], 'chain': [574], 'reaction–amplified': [575], 'products.10': [576], 'summarized': [578], 'table': [581], 'among': [583, 598, 654, 668, 760], 'homozygous': [588, 723, 770, 1018], '(+/+)': [592], '36.7%': [594], '(22': [595], '60);': [597], 'subjects,': [600, 2554], 'it': [601], '21.4%': [603], '(39': [604], 'individuals;': [607], 'P<.05,': [608], 'χ2': [609, 631, 709], 'test).': [610, 632, 1130], 'Elevated': [611, 1065, 1145, 1455], 'detected': [615, 720], '13': [617], '(21.6%)': [621], '18': [624], '(9.8%)': [629], '(P<0.05,': [630], 'Mean': [633], '15.8±14.6': [636], '12.5±7.8': [641], 'controls': [644, 1093, 1099, 1128], '(P<.005,': [645], 't-test).': [646], 'By': [647, 790, 2246], 'analyzing': [648], 'hyperhomocysteinemic': [652], 'different': [656], 'genotypes,': [658], 'significantly': [660, 775, 1978], 'higher': [661, 715, 931, 1587], 'elevated': [664], '+/+': [669, 679, 722], 'compared': [671, 1775], 'other': [673, 942, 1031, 1924], 'genotypes.': [674], 'Nine': [675], '22': [678], '(40.9%)': [681], 'showed': [682, 820], 'distribution.': [693], 'Only': [694, 2080], '38': [698], '(10.5%)': [699], 'nonhomozygotes': [700, 727], '(+/−': [701], '−/−)': [703], 'behaved': [704], 'similarly': [705], '(P<.005': [706], 'test,': [710], 'nonhomozygotes).': [713], 'Accordingly,': [714, 815], 'than': [725, 943, 1590, 1856, 1980, 2044, 2182], '(23.3±22.2': [728], '11.8+4.9;': [731], 'P<.005.': [732], 'Similar': [733], 'findings': [736, 846], 'al,8': [740], 'inversely': [744], 'folate': [747, 2007, 2868], '(r=−.26;': [749], 'P<.001)': [750], 'setting.': [753], 'Folate': [754], 'did': [757, 1596], 'not': [758, 1597, 1678, 1745, 2134, 2153, 2166, 2173, 2596], 'differ': [759], 'logistic': [766, 1933], 'regression': [767, 818, 1934], 'model,': [768, 798, 1935], '(odds': [780, 805], 'ratio,': [781, 806], '2.1;': [782], '95%': [783, 808], 'confidence': [784, 809, 1943], 'interval,': [785, 810], '1.1': [786], '4.0;': [788], 'P=.02).': [789], 'excluding': [791], 'became': [803], '1.03;': [807], '1.001': [811], '1.06;': [813], 'P=.04).': [814], 'multiple': [817], 'major': [827, 1747], 'determinant': [828], '(β': [831], 'coefficient=8.67;': [832], 'P<.001).Several': [833], 'concepts': [834], 'should': [835, 2122, 2178, 2219], 'be': [836, 982, 1046, 1530, 2005, 2179, 2188, 2205, 2220], 'taken': [837], 'into': [838], 'account': [839], 'understanding': [841], 'differences': [842], 'present': [845], 'those': [848, 1026], 'al.': [852], 'only': [856, 1048, 1567, 1631, 1812, 1937, 2187], 'individuals': [857, 2100], 'enrolled.': [862], 'Patient': [863], 'al': [872, 1663, 2020], '65.7': [874], 'years.': [875, 2000], 'An': [876, 2061], 'unknown': [877], 'proportion': [878], 'report;': [887], 'whole,': [898], 'allowed': [908], 'identification': [909], 'almost': [911], '40%': [912], 'It': [920], 'known': [922], 'help': [928], 'numbers': [932, 1627], 'thrombophilic': [934], 'metabolic': [938], 'abnormality.9': [939], 'factors': [941, 1926], 'play': [948], 'role': [950], 'regulating': [952], 'levels.': [955, 1647, 2032, 2060], 'strong': [957, 1896], 'linkage': [958], 'setting': [967, 980], 'further': [968], 'supports': [969], 'association.': [971], 'high': [973, 2108], 'frequency': [974, 1014, 1485, 1701, 1715, 1791, 1827, 2109], 'may': [981, 991, 1529, 1949], 'result': [984, 1595, 1623, 1650], 'inappropriate': [987], 'sample': [988, 1626], 'selection': [989], 'greatly': [993], 'contributed': [994], 'independent': [999, 1152, 1176], 'here.': [1009], 'figures': [1011], 'state': [1019], 'populations': [1022], 'are': [1023, 1037, 1915, 2133, 2142, 2152, 2157, 2165, 2172, 2192, 2652], 'groups,1011': [1032], 'combined': [1035], 'data': [1036, 1576], 'consistent': [1038, 1652], 'possibility': [1041], 'genotype-based': [1043], 'observations': [1044], 'can': [1045, 2072], 'applied': [1047], 'ethnic': [1050], 'groups': [1051, 1795], 'similar': [1053, 1544], 'background.': [1055], 'Table': [1056], '1.': [1057], 'Prevalence': [1058, 1415, 2393], 'Homozygous': [1060], 'Among': [1067], 'Control': [1077], 'SubjectsPatients': [1078], '(n=60)Controls': [1079], '(n=182)Homozygotes': [1080], '(+/+)*22/60': [1081], '(36.7%)39/182': [1082], '(21.4%)tHcy': [1083], '(μM)†15.8±14.612.5±7.8Subjects': [1084], 'elevated‡': [1086], 'tHcy§13/60': [1087], '(21.6%)18/182': [1088], '(9.8%)*P=.035': [1089], 'vs': [1092, 1098, 1127], '(χ2': [1094, 1129], 'test).†P=.004': [1095], '(t': [1100], 'test).‡Elevated': [1101], 'indicates': [1103], 'age-matched': [1116], 'men': [1118], '(19.5': [1119], 'μM)': [1120], 'women': [1122], '(15': [1123], 'μM).§P=.03': [1124], 'References': [1131, 2191], '1': [1132, 2728], 'Coull': [1133, 3029], 'BM,': [1134], 'Malinow': [1135, 1192, 1351], 'MR,': [1136, 1193, 1352], 'Beamer': [1137, 3022], 'N,': [1138, 2641, 2764, 2799, 3023], 'Sexton': [1139], 'G,': [1140, 1410, 1412, 1440, 1449, 1452, 2766], 'Nordt': [1141], 'F,': [1142, 1481, 2368, 2569], 'deGarmo': [1143], 'P.': [1144], 'homocyst(e)ine': [1147, 1205], 'concentration': [1148, 1232], 'possible': [1151], 'factor': [1154, 1178, 1273, 1329, 1533, 1749, 1770, 2003], 'Stroke.1990;': [1157], '21:572–576.CrossrefMedlineGoogle': [1158], 'Scholar2': [1159], 'Clarke': [1160], 'R,': [1161, 1249, 1308, 1379, 1408, 1434, 2366, 2370, 2855, 2922, 2967, 3021, 3064], 'Daly': [1162], 'L,': [1163, 1479, 2248, 2250, 2526], 'Robinson': [1164], 'K,': [1165, 2302, 2419, 2567], 'Naughten': [1166], 'E,': [1167, 1477, 2639, 2961, 2963, 3058], 'Cahalane': [1168], 'S,': [1169, 1406, 2331, 2372, 2374, 2752], 'Fowler': [1170], 'B,': [1171, 2329, 2578], 'Graham': [1172], 'I.': [1173], 'Hyperhomocysteinemia:': [1174], 'disease.': [1181, 1332, 1398, 1469], 'N': [1182, 2474], 'Engl': [1183], 'J': [1184, 1334, 1471, 2534, 2580], 'Med.1991;': [1185], '324:1149–1155.CrossrefMedlineGoogle': [1186], 'Scholar3': [1187], 'Verhoef': [1188], 'P,': [1189, 1245, 1251, 1296, 1346, 2574], 'Hennekens': [1190, 1343], 'CH,': [1191, 1344], 'Kok': [1194], 'FJ,': [1195], 'Willett': [1196, 1353], 'WC,': [1197, 1354], 'Stampfer': [1198, 1341], 'MJ.': [1199], 'A': [1200, 1269, 1386, 2537, 2711, 2933], 'prospective': [1201], 'Stroke.1994;': [1211], '25:1924–1930.CrossrefMedlineGoogle': [1212], 'Scholar4': [1213], 'Perry': [1214], 'IJ,': [1215], 'Refsum': [1216], 'H,': [1217, 2417, 2425], 'Morris': [1218], 'RW,': [1219], 'Ebrahim': [1220], 'SB,': [1221], 'Ueland': [1222], 'PM,': [1223], 'Shaper': [1224], 'AG.': [1225], 'Prospective': [1226], 'total': [1230, 1456], 'middle-aged': [1238], 'British': [1239], 'men.': [1240], 'Lancet.1995;': [1241], '346:1395–1398.CrossrefMedlineGoogle': [1242], 'Scholar5': [1243], 'Frosst': [1244, 1295, 1345], 'Blom': [1246, 1309], 'HJ,': [1247], 'Milos': [1248], 'Goyette': [1250], 'Sheppard': [1252], 'CA,': [1253], 'Matthews': [1254], 'RG,': [1255], 'Boers': [1256, 1293], 'GHJ,': [1257, 1294], 'den': [1258, 1264, 1290, 1302], 'Heijer': [1259, 1303], 'M,': [1260, 1304, 1447, 2327, 2528, 2703, 2705, 2707, 2709, 2754, 2802, 2849, 2926, 3060], 'Kluijtmans': [1261], 'LAJ,': [1262, 1288], 'van': [1263, 1289, 1299], 'Heuvel': [1265, 1291], 'LP,': [1266], 'Rozen': [1267, 1307, 1355], 'R.': [1268, 1356], 'candidate': [1270, 2076], 'disease:': [1276], 'methylenetetrahydrofolate': [1281, 1391, 1492, 2262, 2543], 'reductase.': [1282], 'Nat': [1283], 'Genet.1995;': [1284], '10:111–113.CrossrefMedlineGoogle': [1285], 'Scholar6': [1286], 'LPWJ,': [1292], 'Stevens': [1297], 'EMB,': [1298], 'Oost': [1300], 'BA,': [1301], 'Trijbles': [1305], 'FJM,': [1306], 'HJ.': [1310], 'Molecular': [1311, 3048], 'mild': [1315], 'hyperhomocysteinemia:': [1316], 'methylene-tetrahydrofolate': [1322], 'Am': [1333, 1470], 'Hum': [1335, 1472], 'Genet.1996;': [1336, 1473], '58:35–41.MedlineGoogle': [1337], 'Scholar7': [1338], 'Ma': [1339], 'J,': [1340, 1348, 1350, 1383, 2252, 2421, 2756, 2758, 2808, 2969, 3062], 'MJ,': [1342], 'Sehlub': [1347], 'Horsford': [1349], 'Methylene-tetrahydrofolate': [1357], 'polymorphism,': [1359], 'folate,': [1361, 2027], 'homocysteine,': [1362, 1394, 2482], 'myocardial': [1366], 'infarction': [1367], 'US': [1369], 'physicians.': [1370], 'Circulation.1996;': [1371], '94:2410–2416.CrossrefMedlineGoogle': [1372], 'Scholar8': [1373], 'HS,': [1375], 'Nadira': [1376], 'A,': [1377, 1381, 1438, 2364, 2377, 2379, 2382, 2530, 2637, 2811, 2924, 3025], 'Swaminathan': [1378], 'Sankaralingam': [1380], 'Molloy': [1382], 'Powell': [1384], 'J.': [1385], 'polymorphism': [1388, 1528, 1695, 1766, 1877, 2540, 2594], 'gene,': [1393], 'Stroke.1997;': [1399], '28:1739–1743.CrossrefMedlineGoogle': [1400], 'Scholar9': [1401], 'Fermo': [1402, 1441], 'I,': [1403, 1442, 2524, 2805, 2928], "Vigano'": [1404], 'Paroni': [1407], 'Mazzola': [1409, 1448], 'Calori': [1411], 'A.': [1414], 'venous': [1423], 'thrombosis.': [1426], 'Ann': [1427], 'Intern': [1428], 'Med.1995;': [1429], '123:747–753.CrossrefMedlineGoogle': [1430], 'Scholar10': [1431], 'de': [1432, 2829, 2835, 2842], 'Franchis': [1433], 'Mancini': [1435], 'FP,': [1436], 'Sebastio': [1439], 'De': [1443, 2570], 'Stefano': [1444], 'V,': [1445, 2762], 'Margaglione': [1446], 'Andria': [1453], 'G.': [1454], '677C→T': [1460], '59:262–264.MedlineGoogle': [1474], 'Scholar11': [1475], 'Sacchi': [1476], 'Tagliabue': [1478], 'Duca': [1480], 'Mannucci': [1482], 'PM.': [1483], 'High': [1484], 'Northern': [1497], 'Italy.': [1498], 'Thromb': [1499], 'Haemost.1997;': [1500], '78:963–964.CrossrefMedlineGoogle': [1501], 'ScholarstrokeahaStrokeStrokeStroke0039-24991524-4628Lippincott': [1502], 'Williams': [1503], '&': [1504, 2461], 'WilkinsResponseMarkus': [1505], 'H.S.,': [1506], 'DM041998We': [1507], 'interested': [1509], 'see': [1511], 'results': [1513, 1659, 1899, 1948], 'which': [1521, 1562, 1726, 1883, 1904, 1976, 2071], 'suggests': [1522, 1721], 'Homocysteine': [1537, 3006, 3039], 'using': [1541], 'methodology': [1543], 'but': [1550, 1593, 1784, 2595], 'these': [1551], 'contrast': [1556], 'measured,': [1561], 'performed': [1566, 1759], 'patients.': [1572], 'Consistent': [1573], 'their': [1575, 2040, 2457], 'previous': [1579], 'studies,': [1580], 'controls,': [1592, 1611], 'reach': [1598], 'significance': [1599, 1619], '(mean': [1600], '[SD]': [1601], 'level': [1604], 'cases,': [1606], '1.32': [1607], '[0.19]': [1608, 1613], 'mmol/L;': [1609, 1614], '1.27': [1612], 'P=.09).': [1615], 'This': [1616, 1720, 2238], 'lack': [1617], 'likely': [1621], 'small': [1625], '(homocysteine': [1628], 'subgroup)': [1634], 'weakening': [1638], 'any': [1640], 'use': [1644, 2146], 'Nevertheless,': [1648], 'existing': [1655], 'literature': [1656], 'raised': [1668], 'risk.': [1673], 'contrast,': [1675], 'there': [1676, 1785, 1802], 'even': [1679], 'trend': [1681], 'toward': [1682], 'homozygocity': [1689], '(TT)': [1690], '(TT': [1699, 1826], 'cases': [1703, 2118], '10.7%': [1705], '13.7%': [1707], 'controls;': [1709], 'P=.34)': [1710], 'T': [1713, 2336, 2828, 3027], 'allele': [1714], '(0.68': [1716], '0.67;': [1718], 'P=.67).': [1719], 'population,': [1725, 2604], 'unselected': [1729], 'group': [1730], 'white': [1733], 'presenting': [1735], 'TIA,': [1740], 'mentioned': [1753], 'article,': [1756], 'determine': [1763], 'whether': [1764, 2097], 'no': [1781, 1787, 1804, 2180], 'infarct,': [1783], 'difference': [1788, 1953], 'TT': [1790, 1909, 2112], 'two': [1794, 1956], '(11.1%': [1796], '9.5%;': [1798], 'P=.69).': [1799], 'addition,': [1801, 2105], 'when': [1811], '157': [1814], 'case': [1815, 1831], '79': [1818], '<65': [1822], 'years,': [1823], 'considered': [1825], '13.5%': [1829], '15.2%': [1834], 'subjects;': [1837], 'P=.70).': [1838], 'Unfortunately,': [1839], 'because': [1840], 'error': [1843], 'editing': [1846], 'stage,': [1847], 'line': [1849], 'printed': [1851], '≥65': [1853], 'rather': [1855], '≤65': [1858, 1999], 'original': [1862], 'manuscript.': [1863], 'majority': [1865], 'date': [1869], 'looking': [1870], 'risk,': [1880, 2624], 'looked': [1885], 'heart': [1888], 'disease,': [1889], 'association.Therefore,': [1897], 'al,': [1903], 'strikingly': [1907], 'increased': [1908], 'patients,': [1914], 'variance': [1917], 'ours.': [1919], 'association,': [1922], 'once': [1923], 'accounted': [1929], 'just': [1938], 'significant,': [1939], 'lower': [1942, 1979, 2043], 'interval': [1944], '1.1.': [1946], 'These': [1947], 'reflect': [1950], 'real': [1952], 'populations.': [1957], 'they': [1960], 'young,': [1963], '34': [1969], 'youngest': [1972], '4,': [1975], 'both': [1981, 2116], 'patient': [1987], 'Another': [2001], 'important': [2002], 'could': [2004], 'intake': [2008, 2038], 'population.': [2011], 'Both': [2012], 'interaction': [2024], 'Therefore,': [2033], 'if': [2034], 'folic': [2036], 'ours,': [2047], 'will': [2051, 2186, 2204], 'greater': [2054], 'effect': [2055, 2660, 2898], 'determining': [2057], 'alternative': [2062], 'explanation': [2063], 'chance': [2069], 'finding,': [2070], 'frequently': [2073], 'happen': [2074], 'studies.': [2079], 'studied.': [2084], 'No': [2085], 'information': [2086], 'given': [2088], 'about': [2089, 2452], 'how': [2090], 'recruited': [2095], 'ethnically': [2102], 'homogenous.': [2103], 'relatively': [2107], 'eLetters(0)eLetters': [2121], 'relate': [2123], 'article': [2126, 2199], 'published': [2128, 2167], 'journal': [2131, 2161], 'forum': [2136], 'providing': [2138], 'unpublished': [2139], 'data.': [2140], 'Comments': [2141, 2151, 2164, 2177], 'reviewed': [2143], 'appropriate': [2145], 'tone': [2148], 'language.': [2150], 'peer-reviewed.': [2154], 'Acceptable': [2155], 'comments': [2156], 'posted': [2158, 2189], 'website': [2162], 'only.': [2163], 'issue': [2170], 'indexed': [2174], 'PubMed.': [2176], 'longer': [2181], '500': [2183], 'words': [2184], 'online.': [2190], 'limited': [2193], '10.': [2195], 'Authors': [2196], 'cited': [2200], 'comment': [2203], 'invited': [2206], 'reply,': [2208], 'appropriate.Comments': [2210], 'feedback': [2212], 'AHA/ASA': [2214, 2224], 'Scientific': [2215], 'Statements': [2216], 'Guidelines': [2218], 'directed': [2221], 'Manuscript': [2225], 'Oversight': [2226], 'Committee': [2227], 'via': [2228], 'its': [2229], 'Correspondence': [2230], 'page.Sign': [2231], 'Submit': [2234], 'Response': [2236], 'Article': [2239, 3096], 'Previous': [2240], 'Back': [2241], 'top': [2243], 'Next': [2244], 'FiguresReferencesRelatedDetailsCited': [2245], 'Huang': [2247], 'Li': [2249, 2251], 'Chen': [2253], 'X': [2254], 'Yu': [2256], 'M': [2257, 2430, 2583, 2678, 2714, 2768, 2771, 2861, 2971, 2974, 3069], '(2022)': [2258], 'Association': [2259, 2338, 2585], '(': [2264], ')': [2266], 'variant': [2268], 'severity': [2276], 'ischaemic': [2278], 'stroke:': [2279, 2480, 2658], 'case–control': [2281], 'southwest': [2285], 'China': [2287], 'Journal': [2289, 2350, 2555, 2606, 2625, 2690, 2741, 2784, 2876, 2909, 2947, 2989, 3079], 'International': [2291], 'Medical': [2292, 2322, 2912], 'Research,': [2293], '10.1177/03000605221081632,': [2294], '50:2,': [2295], '(030006052210816),': [2296], 'Online': [2297, 2357, 2466, 2499, 2562, 2612, 2632, 2673, 2698, 2747, 2790, 2883, 2917, 2956, 2996, 3016, 3053, 3086], 'publication': [2298, 2358, 2467, 2500, 2563, 2613, 2633, 2674, 2699, 2748, 2791, 2884, 2918, 2957, 2997, 3017, 3054, 3087], 'date:': [2299, 2359, 2468, 2501, 2564, 2614, 2634, 2675, 2700, 2749, 2792, 2885, 2919, 2958, 2998, 3018, 3055, 3088], '1-Feb-2022.': [2300], 'Manysheva': [2301], 'Abusueva': [2303], 'B': [2304, 2906, 3030], 'Umakhanova': [2306], 'Z': [2307], '(2021)': [2308], 'Role': [2309, 3032], 'mutations': [2311], 'occurrence': [2318], 'stroke,': [2321, 3077], 'alphabet,': [2323], '10.33667/2078-5631-2021-36-41-46:36,': [2324], '(41-46)': [2325], 'Paradkar': [2326], 'Padate': [2328], 'Shah': [2330], 'Vora': [2332], 'H': [2333], 'Ashavaid': [2335], '(2019)': [2337], 'Genetic': [2340, 2476], 'Variants': [2341], 'Indian': [2345, 2349], 'Thrombosis,': [2348], 'Biochemistry,': [2353], '10.1007/s12291-019-00846-9,': [2354], '35:4,': [2355], '(465-473),': [2356], '1-Oct-2020.': [2360], 'Chita': [2361], 'D,': [2362, 2532, 2572], 'Tudor': [2363], 'Christodorescu': [2365], 'Buleu': [2367], 'Sosdean': [2369], 'Deme': [2371], 'Mercea': [2373], 'Pop': [2375], 'Moldovan': [2376], 'Pah': [2378], 'Docu': [2380, 2383], 'Axelerad': [2381, 2384], 'D': [2385, 2817, 2930], 'Dragan': [2387], 'S': [2388, 2471, 2681, 2821], '(2020)': [2389], 'Polymorphisms': [2392], 'Cardiovascular': [2395], 'Risk': [2396], 'Factors': [2397], 'Involved': [2398], 'Cardioembolic': [2400], 'Type': [2402], 'Severity,': [2404], 'Brain': [2405, 2667], '10.3390/brainsci10080476,': [2407], '10:8,': [2408], '(476)': [2409], 'Dong': [2410], 'Y,': [2411], 'Sun': [2412], 'Q,': [2413], 'Liu': [2414, 2422, 2424], 'T,': [2415, 2576, 2760], 'Wang': [2416, 2426], 'Jiao': [2418], 'Xu': [2420], 'X,': [2423, 2814], 'W': [2427], 'Vinci': [2429], '(2016)': [2431, 2975], 'Nitrative': [2432], 'Stress': [2433], 'Participates': [2434], 'Endothelial': [2436], 'Progenitor': [2437], 'Cell': [2438], 'Injury': [2439], 'Hyperhomocysteinemia,': [2441, 2985], 'PLOS': [2442], 'ONE,': [2443], '10.1371/journal.pone.0158672,': [2444], '11:7,': [2445], '(e0158672)': [2446], 'Cacciapuoti': [2447], 'F': [2448], '(2011)': [2449], 'Some': [2450], 'considerations': [2451], 'hypercoagulable': [2454], 'states': [2455], 'treatments,': [2458], 'Blood': [2459], 'Fibrinolysis,': [2462], '10.1097/MBC.0b013e3283436401,': [2463], '22:3,': [2464], '(155-159),': [2465], '1-Apr-2011.': [2469], 'Stankovic': [2470], 'Majkic-Singh': [2473], '(2010)': [2475, 2505], 'aspects': [2477], 'coagulation,': [2481], 'lipoprotein': [2484], 'metabolism': [2485], 'potential': [2487], 'factors,': [2489], 'Critical': [2490], 'Reviews': [2491], 'Laboratory': [2494], '10.3109/10408361003791520,': [2496], '47:2,': [2497], '(72-123),': [2498], '1-Apr-2010.': [2502], 'Baumgartner': [2503], 'R': [2504], 'Management': [2506, 2516], 'Spontaneous': [2508], 'Dissection': [2509], 'Cervical': [2512], 'Carotid': [2513], 'Artery': [2514], 'Surgical': [2515], 'Cerebrovascular': [2518], 'Disease,': [2519], '10.1007/978-3-211-99373-6_9,': [2520], '(57-61),': [2521], '.': [2522, 2847], 'Gorący': [2523, 2533], 'Cyryłowski': [2525], 'Kaczmarczyk': [2527], 'Fabian': [2529], 'Koziarska': [2531], 'Ciechanowicz': [2536], '(2009)': [2538], 'Polish': [2553], 'Applied': [2557, 2627], 'Genetics,': [2558, 2628], '10.1007/BF03195654,': [2559], '50:1,': [2560], '(63-67),': [2561], '1-Mar-2009.': [2565], 'Moe': [2566], 'Woon': [2568], 'Silva': [2571], 'Wong': [2573, 2582], 'Koh': [2575], 'Kingwell': [2577], 'Chin-Dusting': [2579], '(2008)': [2584, 2618, 2865], 'acute': [2587, 2732], 'NOS3': [2598], 'polymorphisms': [2600, 2651, 2663, 2900], 'Singapore': [2603], 'European': [2605, 2740, 2783, 2875, 3078], 'Neurology,': [2608, 2743, 2992, 3082], '10.1111/j.1468-1331.2008.02308.x,': [2609], '15:12,': [2610], '(1309-1314),': [2611], '1-Dec-2008.': [2615], 'Trabetti': [2616], 'E': [2617], 'Homocysteine,MTHFR': [2619], 'polymorphisms,': [2621], 'cardio-cerebrovascular': [2623], '10.1007/BF03195624,': [2629], '49:3,': [2630], '(267-282),': [2631], 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