Publication Information

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2716, 2733, 2756, 2770, 2888, 2903, 3029, 3084, 3195, 3331, 3345, 3362, 3401, 3696, 3808, 3821, 4027, 4034, 4064, 4103, 4369, 4380, 4394, 4397], 'determination': [31, 155, 2705], 'full-length': [34, 158, 996, 3850], 'cDNA': [35, 159, 939, 997, 1176, 2107, 2728, 2758, 2765, 2901, 3060, 3851], 'this': [37, 42, 161, 166, 1083, 1170, 1309, 1708, 2335, 2449, 2461, 2521, 2750, 3390, 3981, 4005, 4035, 4112, 4165, 4349], 'novel': [38, 162], 'protein.': [39, 163, 2562], 'Based': [40, 164], 'upon': [41, 165, 3756], 'information': [43, 167, 3083], 'results': [45, 169, 1189, 3107, 4000], 'from': [46, 170, 731, 985, 1163, 1196, 1374, 1420, 1441, 1453, 1460, 1472, 1480, 1485, 1541, 1605, 1845, 2124, 2143, 2282, 2369, 2410, 2445, 2617, 3058, 3098, 3274, 3284, 3734, 3829, 4111], 'protein': [47, 171, 708, 956, 1179, 1311, 2057, 2071, 2110, 2503, 2731, 2768, 2880, 2905, 3087, 3153, 3397, 3553, 3583, 3610, 3947, 4038, 4060, 4343], 'analysis': [48, 172, 2288, 2305, 2637, 2745], 'mass': [50, 174, 268, 2091, 2103, 2704, 3229], 'spectrometry,': [51, 175], 'we': [52, 176, 1172, 4016, 4031, 4099], 'propose': [53, 177], 'a': [54, 121, 178, 245, 291, 480, 501, 543, 609, 743, 946, 974, 986, 1209, 1305, 1316, 1330, 1567, 1595, 1654, 1710, 1759, 1777, 1864, 1928, 2066, 2098, 2170, 2218, 2223, 2265, 2280, 2316, 2352, 2467, 2540, 2684, 2689, 2904, 3026, 3247, 3269, 3281, 3339, 3384, 3561, 3605, 3744, 3770, 4080, 4118, 4123, 4297, 4340, 4354, 4360], 'scheme': [55, 179, 1339], 'define': [57, 181, 1343, 1566, 4004], 'structural': [59, 183, 3296], 'organization': [60, 184, 3297], 'in': [63, 187, 290, 519, 548, 979, 1191, 1201, 1307, 1313, 1670, 1720, 1772, 1940, 1950, 2065, 2115, 2279, 2351, 2429, 2436, 2485, 2504, 2520, 2547, 2609, 2627, 2688, 2749, 2780, 2898, 2915, 3064, 3078, 3104, 3167, 3246, 3260, 3305, 3604, 3712, 3800, 3836, 3844, 3996, 4014, 4088, 4339, 4371, 4382], 'relation': [64, 188], 'its': [66, 190, 1184, 3602, 3748], 'precursor': [67, 191, 987, 1185, 1332, 1345, 2773], 'forms,': [68, 192], 'proheparanase': [69, 193, 3172, 3188], 'pre-proheparanase.': [71, 195], 'The': [72, 96, 196, 220, 950, 1153, 1603, 1675, 1730, 1764, 1809, 1891, 2131, 2337, 2405, 2527, 2551, 2658, 3081, 3134, 3184, 3255, 3357, 3540], '8-': [73, 197, 2161, 2198, 2581, 2659, 4021], '50-kDa': [75, 199, 1211, 1310, 2145, 2163, 2200, 2317, 2518, 2583, 2649, 2661, 3086, 3396, 3552, 3609, 3946, 4023], 'which': [77, 201, 1308, 2720], 'make': [78, 202], 'up': [79, 203], 'active': [81, 205, 1302, 1728, 1752, 2203, 3381, 3741, 3781, 3978], 'enzyme': [82, 206, 830, 1303, 1355, 1575, 2129, 2533, 2630, 3382, 3391, 4028, 4077], 'reside,': [83, 207], 'respectively,': [84, 208], 'at': [85, 209, 716, 1738, 1813, 1821, 1895, 1902, 3090, 3341, 3578, 3707, 4097], 'NH2-': [87, 211], 'COOH-terminal': [89, 213, 3092, 3214, 3775], 'regions': [90, 214, 2126], 'inactive': [93, 217], 'precursor,': [94, 218, 2891], 'proheparanase.': [95, 219, 1337, 3206], 'heterodimer': [98, 222, 1306], 'is': [99, 112, 120, 223, 236, 244, 952, 973, 983, 1208, 1304, 1340, 2427, 2608, 2761, 2896, 3023, 3103, 3383, 3399, 3572, 3591, 3693, 3726, 3754, 3764, 3814, 3841], 'produced': [100, 224], 'by': [101, 225, 625, 668, 994, 1327, 1363, 1384, 1527, 1588, 1735, 1834, 1927, 1944, 1966, 2061, 2137, 2208, 2331, 2341, 2483, 2667, 2681, 2706, 3025, 3067, 3075, 3949, 4051, 4300], 'excision': [102, 226, 3768], 'loss': [104, 228, 4075], 'an': [106, 230, 836, 1920, 2618, 3366, 4104, 4108], 'internal': [107, 231], 'linking': [108, 232, 2159], 'segment.': [109, 233], 'This': [110, 234, 602, 719, 2364, 2607, 2760, 2900, 3102, 3162, 3347], 'paper': [111, 235, 1155, 4299], 'first': [114, 238, 842, 3364], 'suggest': [116, 240, 1299, 3349], 'that': [117, 241, 713, 970, 982, 1206, 1300, 1572, 1576, 1592, 2188, 2227, 2599, 3176, 3243, 3350, 3379, 3394, 3638, 3689, 3730, 3752, 3985, 4018, 4058, 4115], 'human': [118, 242, 948, 1164, 1358, 2734, 2771, 4175], 'two-chain': [122, 246], 'enzyme.': [123, 247], 'heparan': [248, 286, 2322], 'sulfate': [249, 287], 'proteoglycan': [250], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine': [251], 'glutathione': [252, 1644], 'dithiothreitol': [253, 1647], 'size': [254, 1780, 2342], 'exclusion': [255, 1781, 2343], 'chromatography': [256, 275, 1782, 2344], 'column': [257, 1655, 1676, 1731, 1784, 1810, 1866, 1892, 1913, 1923, 2219, 2263, 2686], 'volume': [258], 'polyacrylamide': [259, 1430, 2014], 'gel': [260, 3562, 3705], 'electrophoresis': [261], 'matrix-assisted': [262], 'laser': [263, 2086], 'desorption': [264, 2087], 'time': [265, 2088, 3365], 'flight': [267, 2090], 'spectroscopy': [269, 2092], 'reverse': [270], 'phase': [271, 2140], 'high': [272, 1536, 2346, 2468, 3237, 3708], 'performance': [273], 'liquid': [274], 'trifluoroacetic': [276], 'acid': [277, 943], 'A': [278, 1338, 1722, 2325, 2433, 3532, 3816, 4091], 'vast': [279], 'literature': [280], 'attests': [281], 'importance': [284, 773, 3823], 'proteoglycans': [288], '(HSPG)1': [289], 'variety': [292, 502], 'physiological': [294], 'processes': [295, 552], '(cf.': [296], 'Refs.': [297], '1Ruoslahti': [298], 'E.': [299, 1131, 4311], 'Yamaguchi': [300], 'Y.': [301, 337, 343, 396, 560, 566, 647, 678, 684, 753, 759, 788, 794, 849, 1001, 1112, 1118, 1216, 2785, 2941, 3406, 3860, 4180], 'Cell.': [302, 321, 635], '1991;': [303], '64:': [304], '867-869Abstract': [305], 'Full': [306, 373, 406, 434, 436, 823, 1517, 1519, 1630, 1632, 2250, 2252, 2395, 2397, 4148, 4150], 'Text': [307, 374, 407, 435, 437, 824, 1518, 1520, 1631, 1633, 2251, 2253, 2396, 2398, 4149, 4151], 'PDF': [308, 375, 408, 438, 825, 1521, 1634, 2254, 2399, 4152], 'PubMed': [309, 376, 392, 409, 439, 463, 597, 662, 875, 900, 931, 1027, 1049, 1077, 1136, 1148, 1242, 1264, 1292, 1397, 1522, 1557, 1635, 1978, 2006, 2040, 2255, 2400, 2811, 2833, 2861, 2967, 2989, 3017, 3046, 3129, 3432, 3454, 3482, 3496, 3517, 3628, 3655, 3676, 3792, 3886, 3908, 3936, 3970, 4153, 4206, 4228, 4256, 4270, 4291, 4331], 'Scopus': [310, 326, 410, 440, 464, 598, 640, 663, 876, 901, 932, 1028, 1050, 1078, 1137, 1149, 1243, 1265, 1293, 1398, 1523, 1558, 1636, 1979, 2007, 2041, 2256, 2401, 2812, 2834, 2862, 2968, 2990, 3018, 3047, 3130, 3433, 3455, 3483, 3497, 3518, 3629, 3656, 3677, 3793, 3887, 3909, 3937, 3971, 4154, 4207, 4229, 4257, 4271, 4292, 4332], '(1171)': [311], 'Google': [312, 328, 353, 377, 393, 412, 442, 466, 576, 600, 642, 665, 694, 769, 804, 826, 878, 903, 934, 1030, 1052, 1080, 1128, 1139, 1151, 1245, 1267, 1295, 1400, 1525, 1560, 1638, 1981, 2009, 2043, 2258, 2403, 2814, 2836, 2864, 2970, 2992, 3020, 3049, 3132, 3435, 3457, 3485, 3499, 3520, 3631, 3658, 3679, 3795, 3889, 3911, 3939, 3973, 4156, 4209, 4231, 4259, 4273, 4294, 4334], 'Scholar,': [313, 329, 354, 378, 394, 413, 443, 577, 1031, 1053, 1129, 1140, 1246, 1268, 2815, 2837, 2971, 2993, 3436, 3458, 3486, 3500, 3659, 3890, 3912, 4210, 4232, 4260, 4274], '2Nakajima': [314], 'M.': [315, 445, 457, 579, 591, 629, 651, 851, 859, 1003, 1011, 1218, 1226, 2787, 2795, 2943, 2951, 3408, 3416, 3862, 3870, 4182, 4190, 4305, 4313], 'Irimura': [316, 630], 'T.': [317, 380, 631, 863, 1015, 1230, 2799, 2955, 3420, 3874, 4194], 'Nicolson': [318, 632], 'G.L': [319, 633], 'J.': [320, 367, 428, 634, 656, 817, 1511, 1624, 2244, 2389, 3035, 3492, 3651, 3788, 4142, 4266], 'Biochem.': [322, 636, 924, 1070, 1285, 2002, 2036, 2854, 3010, 3475, 3491, 3650, 3929, 4249, 4265, 4324], '1998;': [323, 460, 594, 637, 3493, 3652, 4267], '36:': [324, 638], '157-167Crossref': [325, 639], '(282)': [327, 641], '3Vlodavsky': [330], 'I.': [331, 554, 649, 672, 747, 782, 847, 865, 869, 999, 1017, 1021, 1106, 1214, 1232, 1236, 2783, 2801, 2805, 2939, 2957, 2961, 3404, 3422, 3426, 3858, 3876, 3880, 4178, 4196, 4200, 4317], 'Eldor': [332, 555, 673, 748, 783, 1107], 'A.': [333, 335, 360, 556, 558, 674, 676, 749, 751, 784, 786, 1108, 1110, 2432], 'Haimovitz-Friedman': [334, 557, 675, 750, 785, 1109], 'Matzner': [336, 559, 677, 752, 787, 1111], 'Ishai-Michaeli': [338, 561, 652, 679, 754, 789, 856, 1008, 1113, 1223, 2792, 2948, 3413, 3867, 4187], 'R.': [339, 562, 653, 680, 755, 790, 855, 857, 1007, 1009, 1114, 1222, 1224, 2791, 2793, 2947, 2949, 3412, 3414, 3866, 3868, 4186, 4188], 'Lider': [340, 563, 681, 756, 791, 1115, 4306], 'O.': [341, 564, 682, 757, 792, 861, 1013, 1116, 1228, 2797, 2953, 3418, 3872, 4192, 4307, 4323], 'Naparstek': [342, 565, 683, 758, 793, 1117], 'Cohen': [344, 567, 685, 760, 795, 1119, 4320], 'I.R.': [345, 568, 686, 761, 796, 1120, 4321], 'Fuks': [346, 569, 687, 762, 797, 1121], 'Z.': [347, 570, 688, 763, 798, 1122], 'Invasion': [348, 571, 689, 764, 799, 1123], 'Metastasis.': [349, 572, 690, 765, 800, 1124], '1992;': [350, 389, 573, 659, 691, 766, 801, 820, 1125], '12:': [351, 574, 692, 767, 802, 1126], '112-127PubMed': [352, 575, 693, 768, 803, 1127], '4Thunberg': [355], 'L.': [356, 867, 1019, 1234, 2803, 2959, 3424, 3878, 4198, 4309], 'Backstrom': [357], 'G.': [358, 2000, 3040], 'Wasteson': [359], 'Robinson': [361], 'C.N.': [362], 'Orgen': [363], 'S.': [364, 400, 453, 587, 915, 1061, 1276, 2034, 2845, 3001, 3037, 3466, 3920, 4240], 'Lindahl': [365], 'U.': [366, 382], 'Biol.': [368, 429, 658, 818, 1512, 1625, 2245, 2390, 4143], 'Chem.': [369, 430, 819, 1513, 1626, 2246, 2391, 4144], '1982;': [370], '257:': [371], '10278-10282Abstract': [372], '5Abrahamsson': [379], 'Brandt': [381], 'Marklund': [383], 'S.L.': [384], 'Sjoquist': [385], 'P.': [386, 923, 1069, 1284, 2853, 3009, 3474, 3928, 4248], 'Circ.': [387], 'Res.': [388, 926, 1072, 1287, 2856, 3012, 3477, 3931, 4251, 4326], '70:': [390], '264-271Crossref': [391], '6Tanaka': [395], 'Adams': [397], 'D.': [398, 423, 1506, 1619, 2239, 2384, 4137, 4315], 'Shaw': [399], 'Immunol.': [401], 'Today.': [402], '1993;': [403], '14:': [404], '111-115Abstract': [405], '(382)': [411], '7Hoogewerf': [414], 'A.J.': [415, 1498, 1611, 2231, 2376, 4129], 'Leone': [416, 1499, 1612, 2232, 2377, 4130], 'J.W.': [417, 1500, 1613, 2233, 2378, 4131], 'Reardon': [418, 1501, 1614, 2234, 2379, 4132, 4368], 'I.M.': [419, 1502, 1615, 2235, 2380, 4133], 'Howe': [420, 1503, 1616, 2236, 2381, 4134], 'W.J.': [421, 1504, 1617, 2237, 2382, 4135], 'Asa': [422, 1505, 1618, 2238, 2383, 4136], 'Heinrikson': [424, 1507, 1620, 2240, 2385, 4138], 'R.L.': [425, 1508, 1621, 2241, 2386, 4139], 'Ledbetter': [426, 452, 586, 1509, 1622, 2242, 2387, 4140, 4379], 'S.R.': [427, 1510, 1623, 2243, 2388, 4141], '1995;': [431, 1514, 1627, 2247, 2392, 4145], '270:': [432, 1515, 1628, 2248, 2393, 4146], '3268-3277Abstract': [433, 1516, 1629, 2249, 2394, 4147], '(96)': [441, 1524, 1637, 2257, 2402, 4155], '8Kato': [444, 578], 'Wang': [446, 580], 'H.': [447, 581, 853, 1005, 1220, 1997, 2789, 2945, 3033, 3410, 3864, 4184, 4319], 'Kainulainen': [448, 582], 'V.': [449, 583], 'Fitzgerald': [450, 584], 'M.L.': [451, 585], 'Ornitz': [454, 588], 'D.M.': [455, 589], 'Bernfield': [456, 590], 'Nat.': [458, 592, 870, 895, 1022, 1044, 1143, 1237, 1259, 2806, 2828, 2962, 2984, 3124, 3427, 3449, 3623, 3881, 3903, 3965, 4201, 4223], 'Med.': [459, 593, 871, 896, 1023, 1045, 1144, 1238, 1260, 2807, 2829, 2963, 2985, 3125, 3428, 3450, 3624, 3882, 3904, 3966, 4202, 4224], '4:': [461, 595], '691-697Crossref': [462, 596], '(287)': [465, 599], 'Scholar': [467], 'reviews': [469], 'additional': [471, 1921], 'references).': [472], 'Not': [473], 'only': [474, 2473], 'do': [475], 'these': [476, 717, 3071, 4070], 'complex': [477, 3687, 3703, 3746, 3758], 'molecules': [478, 3736], 'provide': [479], 'physical': [481], 'barrier': [482], 'movement': [484], 'cells': [486, 547, 670, 730], 'into': [487, 734, 2185], 'tissues,': [488], 'but': [489, 1319, 2302, 4030], 'carbohydrate,': [491], 'or': [492, 524, 550, 2045, 4050], 'glycosylaminoglycan': [493, 698], 'moieties': [494], 'HSPG': [497, 528, 606], 'bind': [498], 'sequester': [500], 'bioactive': [504], 'proteins,': [505], 'including': [506], 'growth': [507], 'factors,': [508], 'chemokines,': [509], 'cytokines,': [510], 'enzymes.': [512, 965], 'These': [513, 2165, 2709, 3797, 4037], 'several': [514], 'proteins': [515, 2662, 3733], 'may': [516, 3300, 3636, 3991], 'be': [517, 2513, 2615, 2656, 3301, 3537, 3637], 'retained': [518], 'complexation': [520], 'with': [521, 1194, 1315, 1665, 1680, 1790, 1852, 1871, 1916, 2026, 2264, 2319, 2472, 2494, 2515, 2539, 2612, 2738, 3106, 3143, 3263, 3585, 3607, 3747, 3849, 4083, 4344, 4356], 'proteoglycans,': [523], 'released': [525], 'when': [526], 'are': [529, 714, 1190, 2746, 2753, 2869, 2911, 3073, 3259, 3806, 4025, 4040, 4062, 4364], 'broken': [530], 'down,': [531], 'thus': [532, 702, 3193], 'providing': [533, 4398], 'mechanisms': [534], 'induction': [536], 'growth,': [538], 'chemotaxis,': [539], 'extravasation': [541], 'diverse': [544], 'set': [545], 'normal': [549], 'disease': [551], '(3Vlodavsky': [553, 671, 746, 781, 1105], 'Scholar).': [601, 770, 1081, 1152, 1401, 2259, 2404, 3050, 3133, 3632, 3796, 3940, 4157, 4295], 'regulatory': [603], 'aspect': [604], 'function': [607, 712, 776], 'impacts': [608], 'wide': [610], 'spectrum': [611], 'biological': [613], 'phenomena': [614], 'underlying': [615], 'inflammatory': [616], 'cardiovascular': [618], 'diseases': [619], 'cancer.': [621], 'Heparanases,': [622], 'enzymes': [623], 'secreted': [624], 'activated': [626], 'platelets': [627], '(2Nakajima': [628], 'Scholar)': [643, 666, 935, 1526, 1561, 1639, 1982, 2010, 2044, 3021, 3680, 3974, 4335], 'neutrophils': [645, 727], '(9Matzner': [646], 'Vlodavsky': [648, 4316], 'Bar-Ner': [650], 'Tauber': [654], 'A.I.': [655], 'Leuk.': [657], '51:': [660], '519-524Crossref': [661], '(32)': [664], 'metastatic': [669], 'Scholar),': [695, 805, 827, 879, 904, 1296, 2865], 'hydrolyze': [696], 'units': [699, 1450], 'HSPG,': [701], 'facilitating': [703], 'release': [704], 'many': [707], 'modulators': [709], 'cell': [711, 1761, 3846], 'bound': [715], 'sites.': [718], 'helps': [720], 'pave': [721], 'way': [723], 'migration': [725], 'cancer': [729], 'vasculature': [733], 'tissues': [735], 'promotes': [737], 'supply': [738], 'blood': [740], 'vessels': [741], 'growing': [744], 'tumor': [745, 1546], 'Although': [771], 'long': [778], 'recognized': [780, 2192], 'bacterial': [807, 964], 'heparanases': [808], 'have': [809, 936, 1087, 3388, 3392, 4159, 4168, 4171], 'thoroughly': [811], 'characterized': [812, 4174], '(10Lohse': [813], 'D.L.': [814, 913, 1059, 1274, 2843, 2999, 3464, 3918, 4238], 'Linhardt': [815], 'R.J.': [816], '262:': [821], '24347-24355Abstract': [822], 'mammalian': [829, 3845], 'remained,': [832], 'until': [833, 1700], 'very': [834], 'recently,': [835], 'elusive': [837], 'target.': [838], 'Now,': [839], 'time,': [843, 1709], 'Vlodavskyet': [844], 'al.': [845, 882, 907, 1386, 3111, 4303], '(11Vlodavsky': [846, 998, 1213, 2782, 2938, 3403, 3857, 4177], 'Friedmann': [848, 1000, 1215, 2784, 2940, 3405, 3859, 4179], 'Elkin': [850, 1002, 1217, 2786, 2942, 3407, 3861, 4181], 'Aingorn': [852, 1004, 1219, 2788, 2944, 3409, 3863, 4183, 4318], 'Atzmon': [854, 1006, 1221, 2790, 2946, 3411, 3865, 4185], 'Bitan': [858, 1010, 1225, 2794, 2950, 3415, 3869, 4189], 'Pappo': [860, 1012, 1227, 2796, 2952, 3417, 3871, 4191], 'Peretz': [862, 1014, 1229, 2798, 2954, 3419, 3873, 4193], 'Michal': [864, 1016, 1231, 2800, 2956, 3421, 3875, 4195], 'Spector': [866, 1018, 1233, 2802, 2958, 3423, 3877, 4197], 'Pecker': [868, 1020, 1235, 2804, 2960, 3425, 3879, 4199], '1999;': [872, 897, 928, 1024, 1046, 1074, 1133, 1145, 1239, 1261, 1289, 2808, 2830, 2858, 2964, 2986, 3014, 3126, 3429, 3451, 3479, 3514, 3625, 3673, 3883, 3905, 3933, 3967, 4203, 4225, 4253, 4288, 4328], '5:': [873, 898, 1025, 1047, 1146, 1240, 1262, 2809, 2831, 2965, 2987, 3127, 3430, 3452, 3626, 3884, 3906, 3968, 4204, 4226], '793-802Crossref': [874, 1026, 1241, 2810, 2966, 3431, 3885, 4205], '(726)': [877, 1029, 1244, 2813, 2969, 3434, 3888, 4208], 'Hulett': [880, 3109], 'et': [881, 3110, 4302], '(12Hulett': [883, 3112, 3611, 3953], 'M.D.': [884, 1033, 1248, 2817, 2973, 3113, 3438, 3612, 3892, 3954, 4212], 'Freeman': [885, 1034, 1249, 2818, 2974, 3114, 3439, 3613, 3893, 3955, 4213], 'C.': [886, 1035, 1250, 2819, 2975, 3115, 3440, 3488, 3614, 3647, 3894, 3956, 4214, 4262], 'Hamdorf': [887, 1036, 1251, 2820, 2976, 3116, 3441, 3615, 3895, 3957, 4215], 'B.J.': [888, 1037, 1252, 2821, 2977, 3117, 3442, 3616, 3896, 3958, 4216], 'Baker': [889, 1038, 1253, 2822, 2978, 3118, 3443, 3617, 3897, 3959, 4217], 'R.T.': [890, 1039, 1254, 2823, 2979, 3119, 3444, 3618, 3898, 3960, 4218], 'Harris': [891, 1040, 1255, 2824, 2980, 3120, 3445, 3619, 3899, 3961, 4219], 'M.J.': [892, 1041, 1256, 2825, 2981, 3121, 3446, 3620, 3900, 3962, 4220], 'Parish': [893, 1042, 1257, 2826, 2982, 3122, 3447, 3489, 3621, 3648, 3901, 3963, 4221, 4263], 'C.R.': [894, 1043, 1258, 2032, 2827, 2983, 3123, 3448, 3490, 3622, 3649, 3902, 3964, 4222, 4264], '803-809Crossref': [899, 1048, 1263, 2832, 2988, 3128, 3453, 3627, 3907, 3969, 4227], '(487)': [902, 1051, 1266, 2835, 2991, 3131, 3456, 3630, 3910, 3972, 4230], 'Kussieet': [906], '(13Kussie': [908], 'P.H.': [909, 1055, 1270, 2839, 2995, 3460, 3914, 4234], 'Hulmes': [910, 1056, 1271, 2840, 2996, 3461, 3915, 4235], 'J.D.': [911, 1057, 1272, 2841, 2997, 3462, 3916, 4236], 'Ludwig': [912, 1058, 1273, 2842, 2998, 3463, 3917, 4237], 'Patel': [914, 1060, 1275, 2844, 3000, 3465, 3919, 4239], 'Navarro': [916, 1062, 1277, 2846, 3002, 3467, 3921, 4241], 'E.C.': [917, 1063, 1278, 2847, 3003, 3468, 3922, 4242], 'Seddon': [918, 1064, 1279, 2848, 3004, 3469, 3923, 4243], 'A.P.': [919, 1065, 1280, 2849, 3005, 3470, 3924, 4244], 'Giorgio': [920, 1066, 1281, 2850, 3006, 3471, 3925, 4245], 'N.A.': [921, 1067, 1282, 2851, 3007, 3472, 3926, 4246], 'Bohlen': [922, 1068, 1283, 2852, 3008, 3473, 3927, 4247], 'Biophys.': [925, 1071, 1286, 2855, 3011, 3476, 3512, 3671, 3930, 4250, 4286, 4325], 'Commun.': [927, 1073, 1288, 2857, 3013, 3478, 3932, 4252, 4327], '261:': [929, 1075, 1290, 2859, 3015, 3480, 3934, 4254], '183-187Crossref': [930, 1076, 1291, 2860, 3016, 3481, 3935, 4255], '(183)': [933, 1079, 1294, 2863, 3019, 3484, 3938, 4258], 'reported': [937, 3525, 3644, 4336], 'derived': [941, 984, 1178, 1540, 2109, 2730, 2767], 'amino': [942, 990, 2908], 'sequences': [944, 1180, 2058, 2111, 2711, 2732, 2769, 2868, 2937, 3072], 'novel,': [947], 'heparanase.': [949, 1729, 2736, 3586], 'molecule': [951], 'unique': [953], 'among': [954], 'known': [955], 'structures': [957], 'shows': [959], 'no': [960, 2294, 3522], 'homology': [961], 'All': [966], 'three': [967, 2763], 'groups': [968], 'agree': [969], 'single-chain': [975], 'glycoprotein,': [976], 'roughly': [977], '50,000': [978], 'weight,': [981], '543': [989, 2907], 'acids': [991], 'as': [992, 1336, 1382, 1494, 1571, 1586, 2360, 2713, 2894, 2928, 3211, 3303, 3717, 3719, 3743, 4007, 4086], 'defined': [993, 2892, 3948], '12Hulett': [1032, 1247, 2816, 2972, 3437, 3891, 4211], '13Kussie': [1054, 1269, 2838, 2994, 3459, 3913, 4233], 'Clearly,': [1082], 'important': [1084], 'discovery': [1085], 'could': [1086], 'major': [1088, 3270], 'therapeutic': [1089], 'implications': [1090], 'development': [1093], 'new': [1095], 'classes': [1096], 'drugs': [1098], 'cancer,': [1100], 'heart': [1101], 'disease,': [1102], 'inflammation': [1104], '14Finkel': [1130], 'Science.': [1132], '285:': [1134], '33-34Crossref': [1135], '(12)': [1138], '15Eccles': [1141], 'S.A.': [1142], '735-736Crossref': [1147], '(67)': [1150], 'present': [1154, 2877], 'describes': [1156], 'purification': [1158, 2339, 2541, 2743, 3642, 3722], 'characterization': [1160], 'platelets.': [1165], 'During': [1166], 'course': [1168], 'work,': [1171], 'also': [1173, 2329, 4389], 'determined': [1174, 3257], 'molecules,': [1186], 'our': [1188, 1297, 2555, 2724, 2777, 2867, 2924, 3065, 3699, 3999], 'complete': [1192], 'accord': [1193, 3105], 'those': [1195], 'aforementioned': [1198], 'studies.': [1199], 'However,': [1200, 3941], 'contrast': [1202], 'conclusion': [1205], 'single': [1210, 1331], 'findings': [1298], 'works': [1312], 'concert': [1314], 'tightly': [1317], 'associated,': [1318], 'linked,': [1321], '8-kDa': [1322, 2154, 2625, 2652, 3136, 3165, 3201, 3218, 3530, 3541, 3589, 3691, 3826, 4009], 'peptide.': [1323, 3531, 4010], 'Both': [1324, 2489], 'arise': [1326], 'processing': [1328, 1351, 3215, 3370, 3731], 'protein,': [1333], 'designated': [1334, 3074], 'herein': [1335, 2893, 3360], 'proposed': [1341], 'forms': [1346], 'events': [1352, 3371], 'leading': [1353, 3372], 'activation.': [1356], 'Fresh': [1357], 'concentrates': [1360], 'were': [1361, 1372, 1418, 1439, 1451, 1459, 1470, 1479, 1492, 1743, 1754, 1828, 1832, 1849, 1957, 1961, 2023, 2059, 2114, 2118, 2135, 2167, 2183, 2663, 2679, 2696, 2774, 3244], 'obtained': [1362, 1440, 1452, 1471, 2060], 'aphoresis.': [1364], 'Complete': [1365], 'protease': [1366], 'inhibitor': [1367], 'tablets': [1368], 'diisopropyl': [1370], 'fluorophosphate': [1371], 'purchased': [1373, 1419], 'Roche': [1375], 'Molecular': [1376], 'Biochemicals.': [1377], 'H[35S]PG': [1378, 1539], 'substrate': [1379, 1583], 'was': [1380, 1484, 1640, 1677, 1705, 1723, 1733, 1770, 1811, 1819, 1893, 1910, 1914, 1983, 2078, 2095, 2206, 2328, 2366, 2414, 2440, 2536, 2558, 2604, 2779, 3062, 3140, 3226, 3319, 4117], 'prepared': [1381, 2136], 'described': [1383, 1495, 3359], 'Ledbetteret': [1385], '(16Ledbetter': [1387, 1547], 'S.R': [1388, 1548], 'Fisher': [1389, 1549], 'L.W.': [1390, 1550], 'Hassell': [1391, 1551], 'J.R.': [1392, 1552], 'Biochemistry.': [1393, 1553], '1987;': [1394, 1554, 2003], '26:': [1395, 1555], '988-995Crossref': [1396, 1556], '(50)': [1399, 1559], 'Heparin-Sepharose': [1402], 'CL6B': [1403], 'A-Sepharose': [1406], 'Fast': [1407], 'Flow': [1408], 'bulk': [1409], 'media,': [1410], 'Superdex-75': [1412, 1778], 'Hi-Load,': [1413], 'heparin': [1415, 1868, 2419], 'Hi-Trap': [1416, 2420], 'columns': [1417, 1469], 'Amersham': [1421], 'Pharmacia': [1422], 'Biotech.': [1423], 'Precast': [1424], '10–20%': [1425, 2012], 'gradient': [1426, 1713, 1930, 2013, 2266], '10%': [1428], 'homogeneous': [1429], 'gels,': [1431, 2301], 'Tricine': [1432, 1993], 'running': [1433], 'buffer,': [1434], 'weight': [1437, 1447, 1538, 1599, 3569], 'markers': [1438], 'ISS': [1442], 'Enprotech.': [1443], 'Ultra-free-MC': [1444], 'nominal': [1445, 1597], 'limit': [1448, 1600], 'filter': [1449], 'Millipore': [1454], 'Corp.': [1455], 'Polyvinylidene': [1456], 'difluoride': [1457, 2049], 'membranes': [1458, 2050], 'Schleicher': [1461], 'Schuell.': [1463], 'Jupiter': [1464], 'C4': [1465], 'C18': [1467, 2685], 'microbore': [1468], 'Phenomenex,': [1473], 'HPLC-grade': [1475], 'water': [1476, 1854], 'acetonitrile': [1478], 'OmniSolv.': [1481], 'Pyroglutamate': [1482], 'aminopeptidase': [1483], 'Takara': [1486], 'Biomedicals.': [1487], 'Samples': [1488], 'containing': [1489, 1687, 1751, 1796, 1878], 'activity': [1491, 1570, 1964, 2278, 2350, 2409, 2511, 2546, 2553, 3402, 3753, 3840, 4338, 4358], 'identified': [1493], 'earlier': [1496, 2229, 3645, 4109], '(7Hoogewerf': [1497, 1610, 2230, 2375, 4128], 'their': [1528], 'ability': [1529], 'degrade': [1531], 'metabolically': [1532], 'radiolabeled': [1533], 'mice': [1542], 'bearing': [1543], 'Engelbreth-Holm-Swarm': [1545], 'filterable': [1563], 'fragments.': [1564], 'We': [1565, 4158, 4363, 4388], 'unit': [1568], 'amount': [1573, 2620], 'produces': [1577], 'breakdown': [1578], '1%': [1580], 'per': [1584], 'hour,': [1585], 'measured': [1587], 'liberation': [1589], 'counts': [1591], 'pass': [1593], 'through': [1594], '30,000': [1596], 'membrane': [1601], 'filter.': [1602], 'supernatant': [1604], 'activated,': [1606], 'centrifuged': [1607], 'lysates': [1609], 'made': [1641], '1': [1642, 1668, 1688, 1691, 1799, 1882, 2431, 2438, 2487, 2576, 2595, 3144, 3253, 3555], 'mmin': [1643], '(GSH)': [1645], '(DTT)': [1648], 'loaded': [1650, 1771, 1861, 2415], '(1.0': [1651], 'ml/min)': [1652], 'onto': [1653, 1776, 1863, 2416], 'heparin-Sepharose': [1657, 2221], '(1.6': [1658, 1785], '×': [1659, 1786, 2017], '20': [1660], 'cm;': [1661], '40': [1662], 'ml)': [1663, 1750, 1769], 'equilibrated': [1664, 1789, 1870], 'phosphate-buffered': [1666], 'saline,': [1667], 'mm': [1669, 1689, 1692, 1800, 1804, 1886], 'both': [1671, 1986, 3805, 4019], 'GSH': [1672], 'DTT.': [1674], 'then': [1678, 3189], 'washed': [1679, 1915], '0.01': [1681, 1872], 'm': [1682, 1696, 1873, 1880, 2285], 'sodium': [1683, 1792, 1874], 'acetate,': [1684, 1793], 'pH': [1685, 1794, 1876], '5.0,': [1686, 1795], 'GSH,': [1690], 'DTT,': [1693, 1801], '0.35': [1695], 'NaCl': [1697, 1716, 1933, 1939, 1949], '(buffer': [1698, 1807, 1889], 'A)': [1699], 'initial': [1702], 'base': [1703, 1908, 2718, 4373], 'line': [1704, 1909], 'reestablished.': [1706], 'At': [1707], '750-ml': [1711], 'linear': [1712], 'increasing': [1715, 1932, 2268], 'concentration': [1717, 1934], '(0.35–1.5': [1718], 'm)': [1719], 'buffer': [1721, 1917, 1941, 1951, 1994], 'applied': [1724], 'elute': [1726, 2444], 'effluent': [1732, 1818, 1900], 'monitored': [1734, 1820, 1901], 'UV': [1736], 'detection': [1737], '280': [1739, 1822, 1903], 'nm,': [1740], 'aliquots': [1742, 1831, 1960], 'taken': [1744, 2123], 'assay.': [1747], 'Fractions': [1748, 1824, 1953], '(9': [1749], 'pooled': [1755], 'concentrated': [1757], 'using': [1758, 2306], 'stirred': [1760], 'ultrafiltration': [1762, 1765], 'module.': [1763], 'retentate': [1766], '(typically': [1767], '8–10': [1768], '1-ml': [1773, 1865], 'batches': [1774], 'directly': [1775, 1862], 'Hi-Load': [1779], '(SEC)': [1783], '60': [1787], 'cm)': [1788], '0.01m': [1791], '0.5': [1797, 1896], 'mNaCl,': [1798], '10': [1803, 1885, 2018], 'β-octyl': [1805, 1887], 'glucoside': [1806, 1888], 'B).': [1808, 2588], 'run': [1812, 1894], '1.0': [1814], 'ml/min,': [1815], 'nm.': [1823, 1904], '4–6': [1826], 'ml': [1827, 1956], 'collected,': [1829, 1958], 'assayed': [1833, 1962], 'SDS-PAGE': [1835, 1967, 1971, 2287, 2459, 4047], '±': [1836, 1968], 'Western': [1837, 1969, 2052, 2209, 2303, 2332], 'blotting': [1838, 2333], 'activity.': [1842, 2324, 2458, 3697, 4078], 'Pooled': [1843], 'fractions': [1844, 2292, 2320], 'SEC': [1847, 2412], 'step': [1848, 2340, 2413], 'diluted': [1850], '2-fold': [1851], 'deionized': [1853], 'lower': [1856], 'ionic': [1858, 3709], 'strength': [1859, 3710], 'Hi-Trap-Sepharose': [1869], 'phosphate,': [1875], '7.0,': [1877], '0.25': [1879], 'NaCl,': [1881], 'mmDTT,': [1883], 'C).': [1890, 1952], 'ml/min': [1897], 'Once': [1905], 'original': [1907], 'reestablished,': [1911], 'C': [1918, 1942], '5': [1922, 2451], 'volumes': [1924], '(CV),': [1925], 'followed': [1926, 1943], 'biphasic': [1929], '(5': [1935], 'CV': [1936, 1946], '0.25–0.63m': [1938], '23': [1945], '0.63–1.5m': [1948], '2': [1955, 2587, 2597, 4090], 'blotting.': [1970, 2210], '(17Laemmli': [1972], 'U.K.': [1973], 'Nature.': [1974], '1970;': [1975], '227:': [1976], '680-685Crossref': [1977], '(207537)': [1980], 'performed': [1984, 2096, 3320], 'under': [1985, 2463, 2593, 4043], 'reducing': [1987], 'non-reducing': [1989, 2464], 'conditions': [1990, 2465, 4045, 4071], 'employing': [1991], 'system': [1995, 3563], '(18Schagger': [1996], 'Von': [1998], 'Jagow': [1999], 'Anal.': [2001, 2035], '166:': [2004], '368-379Crossref': [2005], '(10505)': [2008], 'gels': [2015, 2022, 3548], '(10': [2016], 'cm).': [2019], 'After': [2020, 2105], 'electrophoresis,': [2021], 'either': [2024], 'stained': [2025, 2300], 'silver': [2027, 2490], '(19Switzer': [2028], 'III,': [2029], 'R.C.': [2030], 'Merril': [2031], 'Shifrin': [2033], '1979;': [2037], '98:': [2038], '231-237Crossref': [2039], '(840)': [2042], 'transferred': [2046], 'polyvinylidene': [2048], 'blot': [2053, 2304], 'analysis.': [2054], 'Peptide': [2055], 'automated': [2062], 'Edman': [2063, 2701, 3317, 3598], 'degradation': [2064, 2702, 3318], 'PE-Biosystems': [2067], 'Procise': [2068], 'Model': [2069, 2073], '494': [2070], 'sequencer.': [2072], '610A': [2074], 'Version': [2075], '2.1': [2076], 'software': [2077], 'employed': [2079], 'data': [2081, 2717, 2754, 4372], 'acquisition': [2082], 'processing.': [2084], 'Matrix-assisted': [2085], '(MALDI-TOF': [2093], 'MS)': [2094], 'on': [2097, 2217, 2299, 2362, 2683, 3321, 3546, 4046], 'Perseptive': [2099], 'Biosystems': [2100], 'Voyager': [2101], 'Elite': [2102], 'spectrometer.': [2104], 'hand,': [2116, 4015], 'antibodies': [2117, 2307, 2496], 'raised': [2119], 'against': [2120, 2308], 'peptide': [2121, 2155, 2310, 2653, 2710, 2742, 2918, 3068, 3137, 3166, 3202, 3221, 3271, 3283, 3590, 3771, 3813], 'antigens': [2122], 'various': [2125], 'sequence.': [2130], 'following': [2132], 'synthetic': [2133], 'peptides': [2134, 2166, 2182, 3031, 3326], 'conventional': [2138], 'solid': [2139], 'methods:NH2-R273KTAKMLKSFLKAGGEVIGGC-COOHand': [2141], 'NH2-V339WLGETSSAYGGC-COOH,': [2142], 'subunit,': [2146], 'andNH2-D105PKKESTFEERSGGC-COOH,': [2147], 'overlapping': [2148], 'COOH': [2150], 'terminus': [2151], 'segment': [2158], 'peptides.': [2164], 'conjugated': [2168], 'maleimide-activated': [2171], 'form': [2172, 4121], 'keyhole': [2174, 2179], 'limpet': [2175, 2180], 'hemocyanin,': [2176], 'hemocyanin-conjugated': [2181], 'injected': [2184], 'rabbits.': [2186], 'Verification': [2187], 'antisera': [2190], 'specifically': [2191], 'peptides,': [2194], 'proheparanase,': [2195], 'polypeptides': [2201, 3776], 'accomplished': [2207], 'Chromatography': [2211], 'crude': [2214, 2548], 'lysate': [2216], 'yielded': [2222, 3233], 'profile': [2224, 2426], 'similar': [2225, 3240], 'published': [2228, 2775, 2936], 'Elution': [2260], '[NaCl]': [2269], 'led': [2270, 3681, 3982], 'recovery': [2272], 'all': [2274, 3322, 3337, 3351], 'region': [2281, 3093, 3170, 3987, 4006], 'about': [2283, 2357, 2537, 2605, 3250], '0.8–1.2': [2284], 'NaCl.': [2286], 'resulting': [2291, 3152], 'revealed': [2293, 2466, 2598], 'hint': [2295], 'segments': [2311], 'correlated': [2312], 'presence': [2314, 2499, 3527, 3714], 'band': [2318, 2327, 2519], 'having': [2321, 3327], 'sulfate-degrading': [2323], '65-kDa': [2326, 2502, 3205], 'observed': [2330], 'fraction.': [2336], 'second': [2338], 'gave': [2345, 2642, 3154], 'resolution': [2347], 'peak': [2353, 2365, 2450, 2462, 2633, 3224], 'comprising': [2354], 'components': [2355, 4039], '20–50': [2358], 'kDa': [2359], 'seen': [2361], 'SDS-PAGE.': [2363], 'clearly': [2367], 'resolved': [2368, 2570], 'elution': [2371, 2425], 'position': [2372], 'chemokines': [2374], 'pool': [2406], 'final': [2418], 'affinity': [2421, 3721], 'column,': [2422, 2447], 'Fig.': [2430, 2437, 2486, 3079, 3293, 4089], 'small': [2434], 'peak,shaded': [2435], 'A,': [2439, 2575, 3223], 'last': [2442], 'fraction': [2452, 2505, 2522], 'contained': [2453], 'most': [2454], 'state': [2469], 'purity,': [2471], 'two': [2474, 2571, 2912, 3234, 3720], 'species': [2475, 2626], 'approximately': [2477], 'kDa,': [2481], 'indicated': [2482], 'arrows': [2484], 'B.': [2488], 'staining': [2491], 'immunostaining': [2493], 'anti-heparanase': [2495], 'showed': [2497, 3338], '4,': [2506], 'where': [2507, 3767], 'low': [2509, 3567, 3580], 'would': [2512, 2614, 3348, 4001], 'consistent': [2514], 'faint': [2517], '(Fig.': [2523, 2586, 2631, 3334, 3554, 4048, 4053], '1,': [2524, 2632], 'lane': [2525], '4).': [2526], 'overall': [2528], 'yield': [2529, 3977], '(22': [2534], 'μg)': [2535, 3139], '6%,': [2538], '160,000-fold': [2543], 'over': [2544], 'extracts.': [2550], 'specific': [2552], '450,000': [2559], 'units/mg': [2560], 'Microbore': [2563], 'RP-HPLC': [2564, 2682, 4052], '(C4)': [2565], 'main': [2572], 'peaks': [2573, 2594, 2641, 2695], '(Fig.2': [2574, 3222], 'and2),': [2577], 'corresponding': [2578, 2882, 3267, 3852], 'species,': [2584], 'respectively': [2585], 'Integration': [2589], 'areas': [2592], 'ratio': [2601, 3248], '2/1': [2603], '6.5/1.': [2606], 'close': [2610], 'agreement': [2611, 3262], 'what': [2613], 'expected': [2616, 3344], 'equimolar': [2619], '50-': [2623], '5).': [2634], 'NH2-terminal': [2635, 3169, 3185, 3773, 3988], 'sequence': [2636, 2881, 3061, 3069, 3082, 3330], 'individual': [2640, 2694], 'sequence:': [2644, 3156], 'KKFKNST': [2645], '…': [2646], 'protein;': [2650], 'appeared': [2654], 'blocked.': [2657], 'subjected': [2664, 3227], 'cleavage': [2666], 'cyanogen': [2668], 'bromide,': [2669], 'trypsin,': [2670], 'lysyl-endopeptidase': [2672], 'generate': [2674], 'fragments': [2675], 'sequencing.': [2677], 'Peptides': [2678], 'isolated': [2680], 'developed': [2687], 'standard': [2690], 'TFA/acetonitrile': [2691], 'system,': [2692], 'lyophilized': [2697], 'submitted': [2699], 'and/or': [2703], 'MALDI-TOF': [2707, 3231], 'MS.': [2708], 'served': [2712], 'searches': [2719, 4374], 'led,': [2721], 'ultimately,': [2722], 'elucidation': [2725], 'Details': [2737], 'regard': [2739], 'not': [2747, 3694, 3738, 4093, 4160], 'included': [2748], 'paper,': [2751], 'nor': [2752, 4167], 'presented': [2755], 'determination.': [2759], 'because': [2762], 'identical': [2764], 'while': [2776, 3810], 'manuscript': [2778], 'preparation': [2781], 'exactly': [2870], 'same.': [2872], 'For': [2873], 'purposes': [2874], 'discussion,': [2878], 'open': [2885], 'reading': [2886], 'frame': [2887], 'pre-proheparanase,': [2895, 3096], 'given': [2897], 'Fig.3.': [2899], 'codes': [2902], 'acids.': [2909], 'There': [2910], 'Met': [2913], 'residues': [2914], 'signal': [2917, 3030, 3178], 'sequence,': [2919], 'Met1': [2920, 2927], 'Met14,': [2922], 'choice': [2925], 'start': [2930], 'site': [2931], 'conforms': [2932], 'previously': [2935], 'supported': [3024], 'prediction': [3027], 'algorithm': [3028], '(20Nielsen': [3032], 'Engelbrecht': [3034], 'Brunak': [3036], 'von': [3038], 'Heijne': [3039], 'Eng.': [3042], '1997;': [3043, 3789], '10:': [3044], '1-6Crossref': [3045], '(4942)': [3048], 'Most': [3051], 'primary': [3054], 'structure': [3055], '(86%)': [3056], 'deduced': [3057], 'confirmed': [3063], 'laboratory': [3066, 4113], 'analysis;': [3070], 'arrowsand': [3076], 'underlining': [3077], '3.': [3080], 'placed': [3088, 3163], 'it': [3089, 3571, 3635, 3725], 'extending': [3097, 3273], 'Lys158': [3099, 3950, 3990], 'Ile543.': [3101], 'blocked': [3135, 3197, 3594], '(∼0.5': [3138], 'hydrolyzed': [3141], 'overnight': [3142], 'milliunit': [3145], 'Pfu': [3147], 'pyroglutamate': [3148], 'aminopeptidase,': [3149], 'Asp37-Val-Val-Asp-Leu.': [3157], '.': [3158, 3159, 3160, 3161], 'evidence': [3175, 3378, 4012, 4102], 'peptidase': [3179], 'cleaved': [3180], 'Ala35-Gln36': [3182], 'bond.': [3183], 'Gln36': [3186], 'cyclized': [3190], 'PCA36,': [3192], 'accounting': [3194], 'NH2-terminals': [3198], 'To': [3207], 'answer': [3208], 'question': [3210], 'component,': [3219], '1)': [3225, 4049], 'spectrometry.': [3230], 'MS': [3232], 'accuracy': [3238], 'weights': [3242], 'found': [3245], '4': [3251], '(Fig.4).': [3254], 'experimentally': [3256], 'excellent': [3261], 'predicted': [3265], '(80%)': [3272], 'PCA36': [3275, 3285], 'Glu109': [3277], '(8247.5': [3278], 'Da)': [3279], 'minor': [3282], 'Lys108': [3287], '(8118.4': [3288], 'Da).': [3289], 'With': [3290], 'reference': [3291], '3,': [3294], 'preproheparanase': [3299], 'represented': [3302], 'Scheme': [3306], 'FS1.Figure': [3307], 'FS1View': [3308], 'Large': [3309], 'Image': [3310], 'Figure': [3311], 'ViewerDownload': [3312], 'Hi-res': [3313], 'image': [3314], 'Download': [3315], '(PPT)': [3316], 'six': [3323, 3352], 'consensus': [3329], 'N-linked': [3332], 'glycosylation': [3333], '4),': [3335], 'gap': [3340], 'positions': [3343], 'Asn.': [3346], 'sites': [3353], 'are,': [3354], 'indeed,': [3355], 'N-glycosylated.': [3356], 'work': [3358], 'presents': [3361], 'understanding': [3367], 'activation': [3374, 3749], 'heterodimer.': [3385, 4106], 'Others': [3386], 'who': [3387, 4170], 'studied': [3389], 'concluded': [3393], 'alone': [3398], 'responsible': [3400], '21Freeman': [3487, 4261], '330:': [3494, 3653, 4268], '1341-1350Crossref': [3495, 3654, 4269], '(173)': [3498, 3657, 4272], '22Gonzalez-Stawinski': [3501, 3660, 4275], 'G.V.': [3502, 3661, 4276], 'Parker': [3503, 3662, 4277], 'W.': [3504, 3663, 4278], 'Holzknecht': [3505, 3664, 4279], 'Z.E.': [3506, 3665, 4280], 'Huber': [3507, 3666, 4281], 'N.S.': [3508, 3667, 4282], 'Platt': [3509, 3668, 4283], 'J.L.': [3510, 3669, 4284], 'Biochim.': [3511, 3670, 4285], 'Acta.': [3513, 3672, 4287], '1429:': [3515, 3674, 4289], '431-438Crossref': [3516, 3675, 4290], '(15)': [3519, 3678, 4293], 'Scholar);': [3521], 'one': [3523, 3559], 'number': [3533], 'explanations': [3535], 'might': [3536], 'considered': [3538], 'here.': [3539], 'fragment': [3542], 'stains': [3543], 'less': [3544], 'intensely': [3545], 'acrylamide': [3547], 'than': [3549], 'does': [3550, 3737], 'B)': [3556], 'and,': [3557, 4096], 'unless': [3558, 3751], 'applies': [3560], 'capable': [3564], 'resolving': [3566], 'components,': [3570], 'likely': [3573], 'go': [3575], 'undetected,': [3576], 'especially': [3577], 'levels': [3581], 'encountered': [3584], 'Moreover,': [3587], 'NH2': [3592], 'terminally': [3593], 'refractive': [3596], 'degradation,': [3599], 'further': [3600], 'complicating': [3601], 'identification': [3603], 'mixture': [3606], 'Of': [3633], 'course,': [3634], 'more': [3640], 'extensive': [3641], 'protocols': [3643], '(21Freeman': [3646], 'dissociation': [3683, 4065], '50/8-kDa': [3686], 'chain': [3692, 3827], 'required': [3695, 4026, 4063], 'In': [3698], 'hands,': [3700], 'however,': [3701], 'survived': [3704], 'filtration': [3706], 'detergent,': [3716], 'well': [3718], 'steps.': [3723], 'Furthermore,': [3724], 'usually': [3727], 'case': [3729], 'progenitor': [3735], 'produce': [3739], 'entity': [3742], 'stable': [3745], 'peptide,': [3750], 'dependent': [3755], 'itself.': [3759], 'An': [3760], 'apt': [3761], 'example': [3762], 'here': [3763], 'procaspase': [3765], 'activation,': [3766], 'bridging': [3772], 'gives': [3777], 'rise': [3778], '2-chain': [3782], '"heterodimeric"': [3783], 'caspase': [3784], '(23Cohen': [3785], 'G.M.': [3786], 'Biochem': [3787], '326:': [3790], '1-16Crossref': [3791], '(4146)': [3794], 'remain': [3799], 'tight,': [3801], 'non-covalent': [3802], 'association,': [3803], 'obligate': [3807, 4105], 'function,': [3809], 'bridge': [3812], 'lost.': [3815], 'final,': [3817], 'compelling': [3819], 'argument': [3820], 'derives': [3828], 'cloning': [3830], 'expression': [3832, 3942], 'done': [3835], 'other': [3837], 'laboratories.': [3838], 'Heparanase': [3839], 'easily': [3842, 4041], 'demonstrated': [3843], 'hosts': [3847], 'transfected': [3848], '543-residue': [3855], 'pre-proheparanase': [3856], 'truncated': [3945], 'Ile543': [3952], 'failed': [3975], 'enzyme,': [3979], 'speculation': [3984], 'play': [3992], 'some': [3993], 'functional': [3994], 'role': [3995], 'catalysis.': [3997], 'Indeed,': [3998], 'serve': [4002], 'Considering': [4011], 'presently': [4013], 'conclude': [4017], 'activity,': [4029], 'lack': [4032, 4100], 'proof': [4033], 'assertion.': [4036], 'separated': [4042, 4085], 'denaturing': [4044], '2).': [4054], 'Unfortunately,': [4055], 'solvent': [4056], 'systems': [4057], 'promote': [4059], 'unfolding': [4061], 'chains,': [4068], 'lead': [4072], 'irreversible': [4074], 'Therefore,': [4079], 'reconstitution': [4081], 'experiment': [4082], 'feasible': [4095], 'present,': [4098], 'definitive': [4101], 'Finally,': [4107], 'report': [4110], 'suggested': [4114], 'post-translationally': [4119], 'modified': [4120], 'CXC': [4124], 'chemokine,': [4125], 'namely': [4126], 'CTAPIII': [4127, 4341], 'able': [4162], 'confirm': [4164], 'observation,': [4166, 4350], 'others': [4169], 'Yet,': [4296], 'recent': [4298], 'Rechter': [4301], '(24Rechter': [4304], 'Cahalon': [4308], 'Baharav': [4310], 'Dekel': [4312], 'Seigel': [4314], 'Shoseyov': [4322], '255:': [4329], '657-662Crossref': [4330], '(27)': [4333], 'fusion': [4342], 'cellulose': [4345], 'binding': [4346], 'domain.': [4347], 'Given': [4348], 'notion': [4352], 'chemokine': [4355], 'remains': [4359], 'controversial': [4361], 'issue.': [4362], 'grateful': [4365], 'Ilene': [4367], 'assistance': [4370], 'Dr.': [4377], 'Steven': [4378], 'help': [4381], 'assay': [4383], 'technology': [4384], 'fruitful': [4386], 'discussions.': [4387], 'acknowledge': [4390], 'Julia': [4391], 'Courval,': [4392], 'RN,': [4393], 'plasmaphoresis': [4395], 'enriched': [4400], 'packs.': [4402]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2105301755', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-09T00:22:57.210840', 'created_date': '2016-06-24'}