Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2105020329', 'doi': 'https://doi.org/10.1158/1535-7163.mct-12-1150', 'title': 'Fibroblast Growth Factor Receptor 3 Is a Rational Therapeutic Target in Bladder Cancer', 'display_name': 'Fibroblast Growth Factor Receptor 3 Is a Rational Therapeutic Target in Bladder Cancer', 'publication_year': 2013, 'publication_date': '2013-05-09', 'ids': {'openalex': 'https://openalex.org/W2105020329', 'doi': 'https://doi.org/10.1158/1535-7163.mct-12-1150', 'mag': '2105020329', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23657946', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3707970'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-12-1150', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/12/7/1245.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://mct.aacrjournals.org/content/molcanther/12/7/1245.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080606297', 'display_name': 'Kilian M. Gust', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Kilian M. Gust', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059536506', 'display_name': 'David J. McConkey', 'orcid': 'https://orcid.org/0000-0003-1971-0638'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'David J. McConkey', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025788173', 'display_name': 'Shannon Awrey', 'orcid': 'https://orcid.org/0000-0001-9905-6853'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Shannon Awrey', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048448388', 'display_name': 'Paul K. Hegarty', 'orcid': 'https://orcid.org/0000-0003-2678-2664'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Paul K. Hegarty', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101131558', 'display_name': 'Jing Qing', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}, {'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jing Qing', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}, {'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111942151', 'display_name': 'Jolanta Bondaruk', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jolanta Bondaruk', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028133447', 'display_name': 'Avi Ashkenazi', 'orcid': 'https://orcid.org/0000-0002-6890-4589'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Avi Ashkenazi', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069116689', 'display_name': 'Bogdan Czerniak', 'orcid': 'https://orcid.org/0000-0002-8289-9173'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Bogdan Czerniak', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002737792', 'display_name': 'Colin P. Dinney', 'orcid': 'https://orcid.org/0000-0002-8969-711X'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Colin P. Dinney', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050196540', 'display_name': 'Peter C. Black', 'orcid': 'https://orcid.org/0000-0002-2919-7068'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': True, 'raw_author_name': 'Peter C. Black', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'The University of Texas MD Anderson Cancer Center, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2The University of Texas MD Anderson Cancer Center, Houston, Texas; and 3Department of Molecular Oncology, Genentech Inc., South San Francisco, California", 'institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5050196540'], 'corresponding_institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I4210150208', 'https://openalex.org/I1343551460'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.997, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 85, 'citation_normalized_percentile': {'value': 0.884369, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '12', 'issue': '7', 'first_page': '1245', 'last_page': '1254'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10458', 'display_name': 'Bladder and Urothelial Cancer Treatments', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9772, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/urothelial-cell', 'display_name': 'Urothelial Cell', 'score': 0.559306}, {'id': 'https://openalex.org/keywords/targeted-therapy', 'display_name': 'Targeted Therapy', 'score': 0.48391062}], 'concepts': [{'id': 'https://openalex.org/C147708747', 'wikidata': 'https://www.wikidata.org/wiki/Q14914358', 'display_name': 'Fibroblast growth factor receptor 3', 'level': 4, 'score': 0.84993833}, {'id': 'https://openalex.org/C2780352672', 'wikidata': 'https://www.wikidata.org/wiki/Q504775', 'display_name': 'Bladder cancer', 'level': 3, 'score': 0.7155698}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.63925344}, {'id': 'https://openalex.org/C82867764', 'wikidata': 'https://www.wikidata.org/wiki/Q24780051', 'display_name': 'Fibroblast growth factor receptor', 'level': 4, 'score': 0.5976464}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5780516}, {'id': 'https://openalex.org/C2910041100', 'wikidata': 'https://www.wikidata.org/wiki/Q11878994', 'display_name': 'Urothelial Cell', 'level': 4, 'score': 0.559306}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5552619}, {'id': 'https://openalex.org/C50044444', 'wikidata': 'https://www.wikidata.org/wiki/Q14911644', 'display_name': 'Fibroblast growth factor receptor 2', 'level': 4, 'score': 0.5166431}, {'id': 'https://openalex.org/C2781230642', 'wikidata': 'https://www.wikidata.org/wiki/Q492646', 'display_name': 'Targeted therapy', 'level': 3, 'score': 0.48391062}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.45597067}, {'id': 'https://openalex.org/C66400584', 'wikidata': 'https://www.wikidata.org/wiki/Q5446458', 'display_name': 'Fibroblast growth factor receptor 4', 'level': 5, 'score': 0.4416215}, {'id': 'https://openalex.org/C74373430', 'wikidata': 'https://www.wikidata.org/wiki/Q24727126', 'display_name': 'Fibroblast growth factor', 'level': 3, 'score': 0.43712837}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.40313607}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.30262733}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2783882}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.2350969}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051498', 'descriptor_name': 'Receptor, Fibroblast Growth Factor, Type 3', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051498', 'descriptor_name': 'Receptor, Fibroblast Growth Factor, Type 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001749', 'descriptor_name': 'Urinary Bladder Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-12-1150', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/12/7/1245.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3707970', 'pdf_url': 'https://europepmc.org/articles/pmc3707970?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707970', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23657946', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-12-1150', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/12/7/1245.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.79, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1761415099', 'https://openalex.org/W1963912235', 'https://openalex.org/W1966803171', 'https://openalex.org/W1982288984', 'https://openalex.org/W1984145333', 'https://openalex.org/W1985060557', 'https://openalex.org/W1988476050', 'https://openalex.org/W1997813643', 'https://openalex.org/W2002714006', 'https://openalex.org/W2006146901', 'https://openalex.org/W2028435559', 'https://openalex.org/W2031541885', 'https://openalex.org/W2050328756', 'https://openalex.org/W2054290966', 'https://openalex.org/W2057976029', 'https://openalex.org/W2077850223', 'https://openalex.org/W2088123597', 'https://openalex.org/W2097986356', 'https://openalex.org/W2098466520', 'https://openalex.org/W2099489143', 'https://openalex.org/W2099900006', 'https://openalex.org/W2101064494', 'https://openalex.org/W2132394486', 'https://openalex.org/W2143033064', 'https://openalex.org/W2143895308', 'https://openalex.org/W2144747113', 'https://openalex.org/W2158294624', 'https://openalex.org/W2159234431', 'https://openalex.org/W2161317196', 'https://openalex.org/W2162861644', 'https://openalex.org/W2167728561', 'https://openalex.org/W2358334832', 'https://openalex.org/W2395526307', 'https://openalex.org/W2524770275'], 'related_works': ['https://openalex.org/W4253770744', 'https://openalex.org/W4249759743', 'https://openalex.org/W4241983134', 'https://openalex.org/W4205487352', 'https://openalex.org/W2789787259', 'https://openalex.org/W2563372231', 'https://openalex.org/W2129594335', 'https://openalex.org/W2029900213', 'https://openalex.org/W1542955689', 'https://openalex.org/W1538827891'], 'abstract_inverted_index': {'Activating': [0], 'mutations': [1, 23], 'of': [2, 14, 28, 32, 39, 61, 96, 107, 119, 133, 142], 'fibroblast': [3], 'growth': [4, 123], 'factor': [5], 'receptor-3': [6], '(FGFR3)': [7], 'have': [8, 63, 90, 115], 'been': [9, 64, 81], 'described': [10, 82], 'in': [11, 26, 36, 50, 98, 128, 154], 'approximately': [12], '75%': [13], 'low-grade': [15], 'papillary': [16], 'bladder': [17, 51, 112, 134, 157], 'tumors.': [18], 'In': [19, 86], 'muscle-invasive': [20], 'disease,': [21], 'FGFR3': [22, 33, 42, 62, 78, 97, 147], 'are': [24], 'found': [25], '20%': [27], 'tumors,': [29], 'but': [30], 'overexpression': [31], 'is': [34, 43], 'observed': [35], 'about': [37], 'half': [38], 'cases.': [40], 'Therefore,': [41], 'a': [44, 72, 105], 'particularly': [45], 'promising': [46], 'target': [47], 'for': [48, 59], 'therapy': [49], 'cancer.': [52, 113, 135, 158], 'Up': [53], 'to': [54, 145], 'now,': [55], 'most': [56], 'drugs': [57], 'tested': [58, 84], 'inhibition': [60, 148], 'small': [65], 'molecule,': [66], 'multityrosine': [67], 'kinase': [68], 'inhibitors.': [69], 'More': [70], 'recently,': [71], 'specific': [73], 'inhibitory': [74, 117], 'monoclonal': [75], 'antibody': [76], 'targeting': [77], '(R3Mab)': [79], 'has': [80], 'and': [83, 93, 104, 124], 'preclinically.': [85], 'this': [87], 'study,': [88], 'we': [89], 'evaluated': [91], 'mutation': [92], 'expression': [94], 'status': [95], '19': [99], 'urothelial': [100], 'cancer': [101], 'cell': [102, 126], 'lines': [103], 'cohort': [106], '170': [108], 'American': [109], 'patients': [110, 155], 'with': [111, 149, 156], 'We': [114], 'shown': [116], 'activity': [118], 'R3Mab': [120, 150], 'on': [121], 'tumor': [122], 'corresponding': [125], 'signaling': [127], 'three': [129], 'different': [130], 'orthotopic': [131], 'xenografts': [132], 'Our': [136], 'results': [137], 'provide': [138], 'the': [139], 'preclinical': [140], 'proof': [141], 'principle': [143], 'necessary': [144], 'translate': [146], 'into': [151], 'clinical': [152], 'trials': [153]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2105020329', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 11}], 'updated_date': '2024-12-10T18:36:05.107728', 'created_date': '2016-06-24'}