Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2104907082', 'doi': 'https://doi.org/10.1523/jneurosci.22-15-06570.2002', 'title': 'Rho Signaling Pathway Targeted to Promote Spinal Cord Repair', 'display_name': 'Rho Signaling Pathway Targeted to Promote Spinal Cord Repair', 'publication_year': 2002, 'publication_date': '2002-08-01', 'ids': {'openalex': 'https://openalex.org/W2104907082', 'doi': 'https://doi.org/10.1523/jneurosci.22-15-06570.2002', 'mag': '2104907082', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12151536', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6758168'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.22-15-06570.2002', 'pdf_url': 'http://www.jneurosci.org/content/jneuro/22/15/6570.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jneurosci.org/content/jneuro/22/15/6570.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041767363', 'display_name': 'Pauline Dergham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70931966', 'display_name': 'Université de Montréal', 'ror': 'https://ror.org/0161xgx34', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I70931966']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Pauline Dergham', 'raw_affiliation_strings': ['Département de pathologie et biologie cellulaire, Université de Montréal, Montréal, Québec H3T 1J4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Département de pathologie et biologie cellulaire, Université de Montréal, Montréal, Québec H3T 1J4, Canada', 'institution_ids': ['https://openalex.org/I70931966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041812677', 'display_name': 'Benjamin Ellezam', 'orcid': 'https://orcid.org/0000-0002-8716-7924'}, 'institutions': [{'id': 'https://openalex.org/I4210100775', 'display_name': 'Laboratoire de Biologie Moléculaire de la Cellule', 'ror': 'https://ror.org/01bj4fd12', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210100596', 'https://openalex.org/I4210100775', 'https://openalex.org/I86767153']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Benjamin Ellezam', 'raw_affiliation_strings': ['Départements de Pathologie et Biologie Cellulaire and'], 'affiliations': [{'raw_affiliation_string': 'Départements de Pathologie et Biologie Cellulaire and', 'institution_ids': ['https://openalex.org/I4210100775']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015722003', 'display_name': 'Charles Essagian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100775', 'display_name': 'Laboratoire de Biologie Moléculaire de la Cellule', 'ror': 'https://ror.org/01bj4fd12', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210100596', 'https://openalex.org/I4210100775', 'https://openalex.org/I86767153']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Charles Essagian', 'raw_affiliation_strings': ['Départements de Pathologie et Biologie Cellulaire and'], 'affiliations': [{'raw_affiliation_string': 'Départements de Pathologie et Biologie Cellulaire and', 'institution_ids': ['https://openalex.org/I4210100775']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033304272', 'display_name': 'Hovsep Avedissian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70931966', 'display_name': 'Université de Montréal', 'ror': 'https://ror.org/0161xgx34', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I70931966']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Hovsep Avedissian', 'raw_affiliation_strings': ['Chimie, Université de Montréal, Montréal, Québec, H3T 1J4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Chimie, Université de Montréal, Montréal, Québec, H3T 1J4, Canada', 'institution_ids': ['https://openalex.org/I70931966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052166021', 'display_name': 'William D. Lubell', 'orcid': 'https://orcid.org/0000-0002-3080-2712'}, 'institutions': [{'id': 'https://openalex.org/I70931966', 'display_name': 'Université de Montréal', 'ror': 'https://ror.org/0161xgx34', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I70931966']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'William D. Lubell', 'raw_affiliation_strings': ['Chimie, Université de Montréal, Montréal, Québec, H3T 1J4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Chimie, Université de Montréal, Montréal, Québec, H3T 1J4, Canada', 'institution_ids': ['https://openalex.org/I70931966']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051781253', 'display_name': 'Lisa McKerracher', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100775', 'display_name': 'Laboratoire de Biologie Moléculaire de la Cellule', 'ror': 'https://ror.org/01bj4fd12', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210100596', 'https://openalex.org/I4210100775', 'https://openalex.org/I86767153']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Lisa McKerracher', 'raw_affiliation_strings': ['Départements de Pathologie et Biologie Cellulaire and'], 'affiliations': [{'raw_affiliation_string': 'Départements de Pathologie et Biologie Cellulaire and', 'institution_ids': ['https://openalex.org/I4210100775']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 14.836, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 716, 'citation_normalized_percentile': {'value': 0.999838, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '22', 'issue': '15', 'first_page': '6570', 'last_page': '6577'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10925', 'display_name': 'Spinal Cord Injury Research', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.71121526}, {'id': 'https://openalex.org/keywords/chondroitin-sulfate-proteoglycan', 'display_name': 'Chondroitin sulfate proteoglycan', 'score': 0.6218993}, {'id': 'https://openalex.org/keywords/hindlimb', 'display_name': 'Hindlimb', 'score': 0.527051}, {'id': 'https://openalex.org/keywords/forelimb', 'display_name': 'Forelimb', 'score': 0.46131206}, {'id': 'https://openalex.org/keywords/growth-cone', 'display_name': 'Growth cone', 'score': 0.46087486}], 'concepts': [{'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.71121526}, {'id': 'https://openalex.org/C2775895372', 'wikidata': 'https://www.wikidata.org/wiki/Q5104536', 'display_name': 'Chondroitin sulfate proteoglycan', 'level': 4, 'score': 0.6218993}, {'id': 'https://openalex.org/C201800478', 'wikidata': 'https://www.wikidata.org/wiki/Q24721770', 'display_name': 'Rho-associated protein kinase', 'level': 3, 'score': 0.6091789}, {'id': 'https://openalex.org/C2780775167', 'wikidata': 'https://www.wikidata.org/wiki/Q9606', 'display_name': 'Spinal cord', 'level': 2, 'score': 0.60327536}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5545826}, {'id': 'https://openalex.org/C51738704', 'wikidata': 'https://www.wikidata.org/wiki/Q5766112', 'display_name': 'Hindlimb', 'level': 2, 'score': 0.527051}, {'id': 'https://openalex.org/C2779530196', 'wikidata': 'https://www.wikidata.org/wiki/Q178999', 'display_name': 'Axon', 'level': 2, 'score': 0.49545825}, {'id': 'https://openalex.org/C171056886', 'wikidata': 'https://www.wikidata.org/wiki/Q193119', 'display_name': 'Regeneration (biology)', 'level': 2, 'score': 0.48985884}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.47752917}, {'id': 'https://openalex.org/C2778646069', 'wikidata': 'https://www.wikidata.org/wiki/Q5468632', 'display_name': 'Forelimb', 'level': 2, 'score': 0.46131206}, {'id': 'https://openalex.org/C135903288', 'wikidata': 'https://www.wikidata.org/wiki/Q559423', 'display_name': 'Growth cone', 'level': 3, 'score': 0.46087486}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.45987195}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.430973}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34884292}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.30205983}, {'id': 'https://openalex.org/C2779335624', 'wikidata': 'https://www.wikidata.org/wiki/Q407976', 'display_name': 'Proteoglycan', 'level': 3, 'score': 0.2831931}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11559695}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001905', 'descriptor_name': 'Botulinum Toxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020127', 'descriptor_name': 'Recovery of Function', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013119', 'descriptor_name': 'Spinal Cord Injuries', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013119', 'descriptor_name': 'Spinal Cord Injuries', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D020741', 'descriptor_name': 'rho GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D036002', 'descriptor_name': 'ADP Ribose Transferases', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D036002', 'descriptor_name': 'ADP Ribose Transferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001369', 'descriptor_name': 'Axons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001369', 'descriptor_name': 'Axons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001369', 'descriptor_name': 'Axons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002469', 'descriptor_name': 'Cell Separation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019922', 'descriptor_name': 'GAP-43 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019922', 'descriptor_name': 'GAP-43 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009043', 'descriptor_name': 'Motor Activity', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009043', 'descriptor_name': 'Motor Activity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009044', 'descriptor_name': 'Motor Cortex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009044', 'descriptor_name': 'Motor Cortex', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009044', 'descriptor_name': 'Motor Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009416', 'descriptor_name': 'Nerve Regeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009416', 'descriptor_name': 'Nerve Regeneration', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009416', 'descriptor_name': 'Nerve Regeneration', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020127', 'descriptor_name': 'Recovery of Function', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020127', 'descriptor_name': 'Recovery of Function', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013119', 'descriptor_name': 'Spinal Cord Injuries', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013119', 'descriptor_name': 'Spinal Cord Injuries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020741', 'descriptor_name': 'rho GTP-Binding Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D020741', 'descriptor_name': 'rho GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054460', 'descriptor_name': 'rho-Associated Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.22-15-06570.2002', 'pdf_url': 'http://www.jneurosci.org/content/jneuro/22/15/6570.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6758168', 'pdf_url': 'https://europepmc.org/articles/pmc6758168?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758168', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12151536', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.22-15-06570.2002', 'pdf_url': 'http://www.jneurosci.org/content/jneuro/22/15/6570.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.67}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W110616860', 'https://openalex.org/W1480239515', 'https://openalex.org/W1513979636', 'https://openalex.org/W1557501694', 'https://openalex.org/W1566509581', 'https://openalex.org/W1574222606', 'https://openalex.org/W1595029695', 'https://openalex.org/W1597787921', 'https://openalex.org/W1646460047', 'https://openalex.org/W1760881456', 'https://openalex.org/W1817027815', 'https://openalex.org/W1826719783', 'https://openalex.org/W1964282467', 'https://openalex.org/W1966778303', 'https://openalex.org/W1979447754', 'https://openalex.org/W1979850552', 'https://openalex.org/W1980713523', 'https://openalex.org/W1983894368', 'https://openalex.org/W1988042413', 'https://openalex.org/W1994901157', 'https://openalex.org/W1996327998', 'https://openalex.org/W1997814123', 'https://openalex.org/W2002422337', 'https://openalex.org/W2006184315', 'https://openalex.org/W2024929479', 'https://openalex.org/W2025778924', 'https://openalex.org/W2030051082', 'https://openalex.org/W2032304318', 'https://openalex.org/W2036098578', 'https://openalex.org/W2039334993', 'https://openalex.org/W2046053356', 'https://openalex.org/W2050415048', 'https://openalex.org/W2051945956', 'https://openalex.org/W2054246670', 'https://openalex.org/W2055519002', 'https://openalex.org/W2056579933', 'https://openalex.org/W2059746822', 'https://openalex.org/W2061572548', 'https://openalex.org/W2064908851', 'https://openalex.org/W2065000241', 'https://openalex.org/W2075892765', 'https://openalex.org/W2087777557', 'https://openalex.org/W2088134619', 'https://openalex.org/W2096791952', 'https://openalex.org/W2097530133', 'https://openalex.org/W2104948489', 'https://openalex.org/W2110106971', 'https://openalex.org/W2110836796', 'https://openalex.org/W2113724937', 'https://openalex.org/W2115203065', 'https://openalex.org/W2115654943', 'https://openalex.org/W2116181102', 'https://openalex.org/W2118078864', 'https://openalex.org/W2124308710', 'https://openalex.org/W2126042399', 'https://openalex.org/W2126706634', 'https://openalex.org/W2130112943', 'https://openalex.org/W2130153447', 'https://openalex.org/W2130731229', 'https://openalex.org/W2135319676', 'https://openalex.org/W2151588652', 'https://openalex.org/W2157441732', 'https://openalex.org/W2161475511', 'https://openalex.org/W2170645579', 'https://openalex.org/W2209268503', 'https://openalex.org/W4244062643'], 'related_works': ['https://openalex.org/W3095683718', 'https://openalex.org/W2619321739', 'https://openalex.org/W2312572943', 'https://openalex.org/W2273020534', 'https://openalex.org/W2222932910', 'https://openalex.org/W2065390408', 'https://openalex.org/W2042190289', 'https://openalex.org/W1987704889', 'https://openalex.org/W1982240373', 'https://openalex.org/W1974265403'], 'abstract_inverted_index': {'The': [0], 'Rho': [1, 24, 58, 93, 130, 149], 'signaling': [2, 150], 'pathway': [3, 131, 151], 'regulates': [4], 'the': [5, 104, 124, 148], 'cytoskeleton': [6], 'and': [7, 9, 71, 117, 137], 'motility': [8], 'plays': [10], 'an': [11], 'important': [12], 'role': [13], 'in': [14, 35, 81, 99, 123], 'neuronal': [15], 'growth': [16, 34], 'inhibition.': [17], 'Here': [18], 'we': [19], 'demonstrate': [20], 'that': [21, 147], 'inactivation': [22, 128], 'of': [23, 38, 73, 92, 112, 120, 129, 135, 140], 'or': [25, 44, 59, 94], 'its': [26], 'downstream': [27], 'target': [28, 155], 'Rho-associated': [29, 95], 'kinase': [30, 96], '(ROK)': [31], 'stimulated': [32], 'neurite': [33], 'primary': [36], 'cells': [37], 'cortical': [39], 'neurons': [40], 'plated': [41], 'on': [42], 'myelin': [43], 'chondroitin': [45], 'sulfate': [46], 'proteoglycan': [47], 'substrates.': [48], 'Furthermore,': [49], 'treatment': [50], 'either': [51], 'with': [52, 60, 88], 'C3': [53], 'transferase': [54], '(C3)': [55], 'to': [56, 62, 67], 'inactivate': [57], 'Y27632': [61], 'inhibit': [63], 'ROK': [64], 'was': [65], 'sufficient': [66], 'stimulate': [68], 'axon': [69], 'regeneration': [70, 111], 'recovery': [72, 134], 'hindlimb': [74], 'function': [75], 'after': [76, 159], 'spinal': [77, 160], 'cord': [78, 161], 'injury': [79], '(SCI)': [80], 'adult': [82], 'mice.': [83], 'Injured': [84], 'mice': [85], 'were': [86], 'treated': [87], 'a': [89, 100, 153], 'single': [90], 'injection': [91], 'inhibitors': [97], 'delivered': [98], 'protein': [101], 'adhesive': [102], 'at': [103], 'lesion': [105], 'site.': [106], 'Treated': [107], 'animals': [108], 'showed': [109], 'long-distance': [110], 'anterogradely': [113], 'labeled': [114], 'corticospinal': [115], 'axons': [116], 'increased': [118], 'levels': [119], 'GAP-43': [121], 'mRNA': [122], 'motor': [125], 'cortex.': [126], 'Behaviorally,': [127], 'induced': [132], 'rapid': [133], 'locomotion': [136], 'progressive': [138], 'recuperation': [139], 'forelimb–hindlimb': [141], 'coordination.': [142], 'These': [143], 'findings': [144], 'provide': [145], 'evidence': [146], 'is': [152], 'potential': [154], 'for': [156], 'therapeutic': [157], 'interventions': [158], 'injury.': [162]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2104907082', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 29}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 'cited_by_count': 31}, {'year': 2015, 'cited_by_count': 44}, {'year': 2014, 'cited_by_count': 41}, {'year': 2013, 'cited_by_count': 33}, {'year': 2012, 'cited_by_count': 43}], 'updated_date': '2024-12-19T02:24:37.476701', 'created_date': '2016-06-24'}