<i>IDH1</i> or <i>IDH2</i> mutations predict longer survival and response to temozolomide in low-grade gliomas

Name: Work Video:
Duration: 3 min 30 s
Caroline Houillier; X. Wang; Gentian Kaloshi; Karima Mokhtari; Rémy Guillevin; Julien Laffaire; S. Paris; Blandine Boisselier; Ahmed Idbaïh; Florence Laigle‐Donadey; Khê Hoang‐Xuan; Marc Sanson; J.‐Y. Delattre
{'id': 'https://openalex.org/W2104669585', 'doi': 'https://doi.org/10.1212/wnl.0b013e3181f96282', 'title': '<i>IDH1</i> or <i>IDH2</i> mutations predict longer survival and response to temozolomide in low-grade gliomas', 'display_name': '<i>IDH1</i> or <i>IDH2</i> mutations predict longer survival and response to temozolomide in low-grade gliomas', 'publication_year': 2010, 'publication_date': '2010-10-25', 'ids': {'openalex': 'https://openalex.org/W2104669585', 'doi': 'https://doi.org/10.1212/wnl.0b013e3181f96282', 'mag': '2104669585', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20975057'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1212/wnl.0b013e3181f96282', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084107178', 'display_name': 'Caroline Houillier', 'orcid': 'https://orcid.org/0000-0003-2931-7522'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'C. Houillier', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210152724', 'https://openalex.org/I154526488', 'https://openalex.org/I4210097159', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034055183', 'display_name': 'X. Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'X. Wang', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210097159', 'https://openalex.org/I39804081', 'https://openalex.org/I154526488', 'https://openalex.org/I4210152724']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016207120', 'display_name': 'Gentian Kaloshi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'G. Kaloshi', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210097159', 'https://openalex.org/I4210152724', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075595989', 'display_name': 'Karima Mokhtari', 'orcid': 'https://orcid.org/0000-0002-4777-7584'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'K. Mokhtari', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I1294671590', 'https://openalex.org/I4210097159', 'https://openalex.org/I39804081', 'https://openalex.org/I4210152724']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036261277', 'display_name': 'Rémy Guillevin', 'orcid': 'https://orcid.org/0000-0002-8650-7827'}, 'institutions': [{'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'R. Guillevin', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I4210097159', 'https://openalex.org/I39804081', 'https://openalex.org/I4210152724', 'https://openalex.org/I1294671590', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051077423', 'display_name': 'Julien Laffaire', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'J. Laffaire', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I39804081', 'https://openalex.org/I4210152724', 'https://openalex.org/I1294671590', 'https://openalex.org/I4210097159', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113709685', 'display_name': 'S. Paris', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'S. Paris', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I39804081', 'https://openalex.org/I154526488', 'https://openalex.org/I1294671590', 'https://openalex.org/I4210097159', 'https://openalex.org/I4210152724']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091708599', 'display_name': 'Blandine Boisselier', 'orcid': 'https://orcid.org/0000-0002-5693-465X'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'B. Boisselier', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210097159', 'https://openalex.org/I39804081', 'https://openalex.org/I4210152724', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100629734', 'display_name': 'Ahmed Idbaïh', 'orcid': 'https://orcid.org/0000-0001-5290-1204'}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'A. Idbaih', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I39804081', 'https://openalex.org/I4210152724', 'https://openalex.org/I154526488', 'https://openalex.org/I1294671590', 'https://openalex.org/I4210097159']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091429631', 'display_name': 'Florence Laigle‐Donadey', 'orcid': 'https://orcid.org/0000-0001-9907-703X'}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'F. Laigle-Donadey', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I39804081', 'https://openalex.org/I4210152724', 'https://openalex.org/I1294671590', 'https://openalex.org/I4210097159', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011185863', 'display_name': 'Khê Hoang‐Xuan', 'orcid': 'https://orcid.org/0000-0003-4072-1999'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'K. Hoang-Xuan', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I4210097159', 'https://openalex.org/I39804081', 'https://openalex.org/I4210152724']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072780405', 'display_name': 'Marc Sanson', 'orcid': 'https://orcid.org/0000-0002-1813-8476'}, 'institutions': [{'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'M. Sanson', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I4210152724', 'https://openalex.org/I154526488', 'https://openalex.org/I1294671590', 'https://openalex.org/I4210097159', 'https://openalex.org/I39804081']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111787978', 'display_name': 'J.‐Y. Delattre', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I4210152724', 'display_name': 'Institut du Cerveau', 'ror': 'https://ror.org/050gn5214', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210152724']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'J.-Y. Delattre', 'raw_affiliation_strings': ["From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France."], 'affiliations': [{'raw_affiliation_string': "From the Service de Neurologie 2-Mazarin (C.H., G.K., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), Laboratoire de Neuropathologie R. Escourolle (K.M.), and Service de Neuroradiologie (R.G.), Groupe Hospitalier Pitié-Salpêtrière (AP-HP), Paris; and INSERM U975 (X.W., K.M., J.L., S.P., B.B., A.I., F.L.-D., K.H.-X., M.S., J.-Y.D.), CNRS UMR 7225 and Université Pierre et Marie Curie Paris VI, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, UMR-S975, Paris, France.", 'institution_ids': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210152724', 'https://openalex.org/I154526488', 'https://openalex.org/I39804081', 'https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 16.447, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 510, 'citation_normalized_percentile': {'value': 0.92923, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '75', 'issue': '17', 'first_page': '1560', 'last_page': '1566'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11600', 'display_name': 'Brain Metastases and Treatment', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11251', 'display_name': 'Meningioma and schwannoma management', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/temozolomide', 'display_name': 'Temozolomide', 'score': 0.92339724}, {'id': 'https://openalex.org/keywords/idh2', 'display_name': 'IDH2', 'score': 0.87702894}, {'id': 'https://openalex.org/keywords/univariate-analysis', 'display_name': 'Univariate analysis', 'score': 0.6077041}, {'id': 'https://openalex.org/keywords/isocitrate-dehydrogenase', 'display_name': 'Isocitrate dehydrogenase', 'score': 0.4949357}], 'concepts': [{'id': 'https://openalex.org/C2777389519', 'wikidata': 'https://www.wikidata.org/wiki/Q425088', 'display_name': 'Temozolomide', 'level': 3, 'score': 0.92339724}, {'id': 'https://openalex.org/C2776059313', 'wikidata': 'https://www.wikidata.org/wiki/Q21116031', 'display_name': 'IDH2', 'level': 5, 'score': 0.87702894}, {'id': 'https://openalex.org/C127848430', 'wikidata': 'https://www.wikidata.org/wiki/Q18027543', 'display_name': 'IDH1', 'level': 4, 'score': 0.8100383}, {'id': 'https://openalex.org/C144301174', 'wikidata': 'https://www.wikidata.org/wiki/Q7893852', 'display_name': 'Univariate analysis', 'level': 3, 'score': 0.6077041}, {'id': 'https://openalex.org/C2778227246', 'wikidata': 'https://www.wikidata.org/wiki/Q1365309', 'display_name': 'Glioma', 'level': 2, 'score': 0.57755494}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5637845}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.50198555}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.49861574}, {'id': 'https://openalex.org/C2777150147', 'wikidata': 'https://www.wikidata.org/wiki/Q261968', 'display_name': 'Isocitrate dehydrogenase', 'level': 3, 'score': 0.4949357}, {'id': 'https://openalex.org/C143589142', 'wikidata': 'https://www.wikidata.org/wiki/Q2617554', 'display_name': 'Loss of heterozygosity', 'level': 4, 'score': 0.45527333}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.44410914}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.40007484}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39391655}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.32691535}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2666649}, {'id': 'https://openalex.org/C38180746', 'wikidata': 'https://www.wikidata.org/wiki/Q1952580', 'display_name': 'Multivariate analysis', 'level': 2, 'score': 0.26500112}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.10114655}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09538284}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.08064982}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018906', 'descriptor_name': 'Antineoplastic Agents, Alkylating', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003606', 'descriptor_name': 'Dacarbazine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007521', 'descriptor_name': 'Isocitrate Dehydrogenase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010597', 'descriptor_name': 'Pharmacogenetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018906', 'descriptor_name': 'Antineoplastic Agents, Alkylating', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D016009', 'descriptor_name': 'Chi-Square Distribution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015254', 'descriptor_name': 'DNA Modification Methylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015254', 'descriptor_name': 'DNA Modification Methylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045643', 'descriptor_name': 'DNA Repair Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045643', 'descriptor_name': 'DNA Repair Enzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003606', 'descriptor_name': 'Dacarbazine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D003606', 'descriptor_name': 'Dacarbazine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007521', 'descriptor_name': 'Isocitrate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019656', 'descriptor_name': 'Loss of Heterozygosity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019656', 'descriptor_name': 'Loss of Heterozygosity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011237', 'descriptor_name': 'Predictive Value of Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013223', 'descriptor_name': 'Statistics as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077204', 'descriptor_name': 'Temozolomide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1212/wnl.0b013e3181f96282', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S79704628', 'display_name': 'Neurology', 'issn_l': '0028-3878', 'issn': ['0028-3878', '1526-632X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20975057', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.66, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1828740957', 'https://openalex.org/W1972705864', 'https://openalex.org/W1974265019', 'https://openalex.org/W2009654197', 'https://openalex.org/W2030964595', 'https://openalex.org/W2039945243', 'https://openalex.org/W2040827479', 'https://openalex.org/W2047731362', 'https://openalex.org/W2052229224', 'https://openalex.org/W2059995145', 'https://openalex.org/W2100901335', 'https://openalex.org/W2104316756', 'https://openalex.org/W2105526612', 'https://openalex.org/W2106649727', 'https://openalex.org/W2107120959', 'https://openalex.org/W2108392589', 'https://openalex.org/W2112495947', 'https://openalex.org/W2121839691', 'https://openalex.org/W2126817554', 'https://openalex.org/W2130948002', 'https://openalex.org/W2134061682', 'https://openalex.org/W2134942438', 'https://openalex.org/W2139644200', 'https://openalex.org/W2143078369', 'https://openalex.org/W2144781683', 'https://openalex.org/W2160300695', 'https://openalex.org/W2168784615', 'https://openalex.org/W2171212160', 'https://openalex.org/W2212083275', 'https://openalex.org/W2307117515'], 'related_works': ['https://openalex.org/W4366704913', 'https://openalex.org/W4307264101', 'https://openalex.org/W2310653790', 'https://openalex.org/W2128680685', 'https://openalex.org/W2126817554', 'https://openalex.org/W2084945856', 'https://openalex.org/W2069303197', 'https://openalex.org/W1979801327', 'https://openalex.org/W1969013165', 'https://openalex.org/W1906458404'], 'abstract_inverted_index': {'Recent': [0], 'studies': [1], 'have': [2], 'shown': [3], 'that': [4, 176], 'IDH1': [5, 30], 'and': [6, 22, 31, 40, 45, 57, 91, 109, 123, 127, 133, 142, 203], 'IDH2': [7, 32], 'mutations': [8, 100], 'occur': [9], 'frequently': [10], 'in': [11, 50, 103, 118, 185, 205], 'gliomas,': [12, 207], 'including': [13], 'low-grade': [14, 25, 55, 206], 'gliomas.': [15], 'However,': [16], 'their': [17], 'impact': [18, 214], 'on': [19, 37, 87, 215], 'the': [20, 161, 164, 216], 'prognosis': [21, 202], 'chemosensitivity': [23, 204], 'of': [24, 35, 53, 64, 154, 160, 163, 200, 209, 218], 'gliomas': [26, 56], 'remains': [27], 'unclear.Search': [28], 'for': [29, 171], 'mutations,': [33], 'loss': [34], 'heterozygosity': [36], 'chromosomes': [38], '1p': [39], '19q,': [41], 'MGMT': [42, 139], 'promoter': [43, 140], 'methylation,': [44, 141], 'p53': [46], 'expression': [47], 'was': [48, 71, 76, 179, 191], 'performed': [49], 'a': [51, 151, 197], 'series': [52], '271': [54], 'correlated': [58, 93, 149], 'with': [59, 69, 94, 114, 150, 181], 'overall': [60, 116], 'survival.': [61], 'A': [62], 'subgroup': [63], '84': [65], 'patients': [66, 105], 'treated': [67], 'up-front': [68], 'temozolomide': [70, 75], 'individualized.': [72], 'Response': [73], 'to': [74, 156, 167, 195, 222], 'evaluated': [77], 'by': [78, 84], 'progression-free': [79, 183], 'survival,': [80], 'as': [81, 83], 'well': [82], 'tumor': [85], 'size': [86], 'successive': [88], 'MRI': [89], 'scans,': [90], 'then': [92], 'molecular': [95], 'alterations.IDH': [96], '(IDH1': [97], 'or': [98], 'IDH2)': [99], 'were': [101, 112, 148], 'found': [102], '132/189': [104], '(70%).': [106], 'IDH': [107, 143, 189], 'mutation': [108, 144, 190, 193], '1p-19q': [110, 137, 177, 210], 'codeletion': [111, 178], 'associated': [113, 180], 'prolonged': [115, 182], 'survival': [117, 184], 'univariate': [119, 186], '(p': [120, 130, 145], '=': [121, 125, 131, 135, 146], '0.002': [122], 'p': [124, 134], '0.0001)': [126], 'multivariate': [128], 'analysis': [129, 159], '0.003': [132], '0.004).': [136], 'codeletion,': [138, 211], '0.01)': [147], 'higher': [152], 'rate': [153], 'response': [155], 'temozolomide.': [157], 'Further': [158], 'course': [162, 217], 'disease': [165], 'prior': [166], 'any': [168], 'treatment': [169], 'except': [170], 'surgery': [172], '(untreated': [173], 'subgroup)': [174], 'showed': [175], 'analysis,': [187], 'whereas': [188, 212], 'not.IDH': [192], 'appears': [194], 'be': [196, 223], 'significant': [198], 'marker': [199], 'positive': [201], 'independently': [208], 'its': [213], 'untreated': [219], 'tumors': [220], 'seems': [221], 'limited.': [224]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2104669585', 'counts_by_year': [{'year': 2024, 'cited_by_count': 19}, {'year': 2023, 'cited_by_count': 33}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 38}, {'year': 2020, 'cited_by_count': 48}, {'year': 2019, 'cited_by_count': 44}, {'year': 2018, 'cited_by_count': 32}, {'year': 2017, 'cited_by_count': 28}, {'year': 2016, 'cited_by_count': 35}, {'year': 2015, 'cited_by_count': 48}, {'year': 2014, 'cited_by_count': 46}, {'year': 2013, 'cited_by_count': 47}, {'year': 2012, 'cited_by_count': 37}], 'updated_date': '2025-01-10T12:11:32.461243', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
