Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2104430226', 'doi': 'https://doi.org/10.1160/th13-11-0902', 'title': 'von Willebrand disease type 2A phenotypes IIC, IID and IIE: A day in the life of shear-stressed mutant von Willebrand factor', 'display_name': 'von Willebrand disease type 2A phenotypes IIC, IID and IIE: A day in the life of shear-stressed mutant von Willebrand factor', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W2104430226', 'doi': 'https://doi.org/10.1160/th13-11-0902', 'mag': '2104430226', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24598842'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1160/th13-11-0902', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206235894', 'display_name': 'Thrombosis and Haemostasis', 'issn_l': '0340-6245', 'issn': ['0340-6245', '2567-689X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048527504', 'display_name': 'Maria A. Brehm', 'orcid': 'https://orcid.org/0000-0003-0416-8233'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Volker Huck', 'raw_affiliation_strings': ['Experimental Dermatology Division, Department of Dermatology, Medical Faculty Mannheim, Heidelberg University'], 'affiliations': [{'raw_affiliation_string': 'Experimental Dermatology Division, Department of Dermatology, Medical Faculty Mannheim, Heidelberg University', 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072806793', 'display_name': 'Volker Huck', 'orcid': 'https://orcid.org/0000-0001-8988-1091'}, 'institutions': [{'id': 'https://openalex.org/I71030271', 'display_name': 'Heidelberg Institute for Theoretical Studies', 'ror': 'https://ror.org/01f7bcy98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I71030271']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Camilo Aponte-Santamaría', 'raw_affiliation_strings': ['Heidelberger Institut fur Theoretische Studien'], 'affiliations': [{'raw_affiliation_string': 'Heidelberger Institut fur Theoretische Studien', 'institution_ids': ['https://openalex.org/I71030271']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068657697', 'display_name': 'Camilo Aponte‐Santamaría', 'orcid': 'https://orcid.org/0000-0002-8427-6965'}, 'institutions': [{'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}, {'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Tobias Obser', 'raw_affiliation_strings': ['Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf', 'institution_ids': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007737542', 'display_name': 'Sandra Grässle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sandra Grässle', 'raw_affiliation_strings': ['Experimental Dermatology Division, Department of Dermatology, Medical Faculty Mannheim, Heidelberg University'], 'affiliations': [{'raw_affiliation_string': 'Experimental Dermatology Division, Department of Dermatology, Medical Faculty Mannheim, Heidelberg University', 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060538127', 'display_name': 'Florian Oyen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}, {'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Florian Oyen', 'raw_affiliation_strings': ['Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf', 'institution_ids': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071353833', 'display_name': 'Ulrich Budde', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210086161', 'display_name': 'Asklepios Klinik Altona', 'ror': 'https://ror.org/00pbgsg09', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086161']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ulrich Budde', 'raw_affiliation_strings': ['MEDILYS Laborgesellschaft mbH, Hemostaseology, Asklepios Klinik Altona'], 'affiliations': [{'raw_affiliation_string': 'MEDILYS Laborgesellschaft mbH, Hemostaseology, Asklepios Klinik Altona', 'institution_ids': ['https://openalex.org/I4210086161']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024178789', 'display_name': 'Sonja Schneppenheim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210086161', 'display_name': 'Asklepios Klinik Altona', 'ror': 'https://ror.org/00pbgsg09', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210086161']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sonja Schneppenheim', 'raw_affiliation_strings': ['MEDILYS Laborgesellschaft mbH, Hemostaseology, Asklepios Klinik Altona'], 'affiliations': [{'raw_affiliation_string': 'MEDILYS Laborgesellschaft mbH, Hemostaseology, Asklepios Klinik Altona', 'institution_ids': ['https://openalex.org/I4210086161']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002969203', 'display_name': 'Carsten Baldauf', 'orcid': 'https://orcid.org/0000-0003-2637-6009'}, 'institutions': [{'id': 'https://openalex.org/I2800875726', 'display_name': 'Fritz Haber Institute of the Max Planck Society', 'ror': 'https://ror.org/03k9qs827', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I2800875726']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Carsten Baldauf', 'raw_affiliation_strings': ['Theory, Fritz Haber Institute, Max Planck Society'], 'affiliations': [{'raw_affiliation_string': 'Theory, Fritz Haber Institute, Max Planck Society', 'institution_ids': ['https://openalex.org/I2800875726']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002969203', 'display_name': 'Carsten Baldauf', 'orcid': 'https://orcid.org/0000-0003-2637-6009'}, 'institutions': [{'id': 'https://openalex.org/I71030271', 'display_name': 'Heidelberg Institute for Theoretical Studies', 'ror': 'https://ror.org/01f7bcy98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I71030271']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Frauke Gräter', 'raw_affiliation_strings': ['Heidelberger Institut fur Theoretische Studien'], 'affiliations': [{'raw_affiliation_string': 'Heidelberger Institut fur Theoretische Studien', 'institution_ids': ['https://openalex.org/I71030271']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054677759', 'display_name': 'Frauke Gräter', 'orcid': 'https://orcid.org/0000-0003-2891-3381'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stefan W. Schneider', 'raw_affiliation_strings': ['Experimental Dermatology Division, Department of Dermatology, Medical Faculty Mannheim, Heidelberg University'], 'affiliations': [{'raw_affiliation_string': 'Experimental Dermatology Division, Department of Dermatology, Medical Faculty Mannheim, Heidelberg University', 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022728813', 'display_name': 'Reinhard Schneppenheim', 'orcid': 'https://orcid.org/0000-0002-8113-7118'}, 'institutions': [{'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}, {'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Reinhard Schneppenheim', 'raw_affiliation_strings': ['Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf', 'institution_ids': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048527504', 'display_name': 'Maria A. Brehm', 'orcid': 'https://orcid.org/0000-0003-0416-8233'}, 'institutions': [{'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}, {'id': 'https://openalex.org/I4210108711', 'display_name': 'University Medical Center Hamburg-Eppendorf', 'ror': 'https://ror.org/01zgy1s35', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Maria A. Brehm', 'raw_affiliation_strings': ['Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf', 'institution_ids': ['https://openalex.org/I159176309', 'https://openalex.org/I4210108711']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.679, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.999869, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '112', 'issue': '07', 'first_page': '96', 'last_page': '108'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11660', 'display_name': 'Diseases Related to Blood Group Variants', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy in Cardiovascular Disease', 'score': 0.989, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/von-willebrand-disease', 'display_name': 'von Willebrand Disease', 'score': 0.626282}, {'id': 'https://openalex.org/keywords/von-willebrand-factor', 'display_name': 'von Willebrand Factor', 'score': 0.588573}], 'concepts': [{'id': 'https://openalex.org/C2778780528', 'wikidata': 'https://www.wikidata.org/wiki/Q709360', 'display_name': 'Von Willebrand disease', 'level': 4, 'score': 0.93021274}, {'id': 'https://openalex.org/C2779394231', 'wikidata': 'https://www.wikidata.org/wiki/Q412310', 'display_name': 'Von Willebrand factor', 'level': 3, 'score': 0.90123534}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.68012863}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.65627265}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.58049303}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.4853648}, {'id': 'https://openalex.org/C26828662', 'wikidata': 'https://www.wikidata.org/wiki/Q7202248', 'display_name': 'Platelet membrane glycoprotein', 'level': 3, 'score': 0.48133287}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.42351344}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39478186}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3192308}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.31811228}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3158693}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26421374}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2633553}], 'mesh': [{'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D056728', 'descriptor_name': 'von Willebrand Disease, Type 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014841', 'descriptor_name': 'von Willebrand Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044085', 'descriptor_name': 'Microfluidics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056004', 'descriptor_name': 'Molecular Dynamics Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D033081', 'descriptor_name': 'Shear Strength', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D033081', 'descriptor_name': 'Shear Strength', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056728', 'descriptor_name': 'von Willebrand Disease, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056728', 'descriptor_name': 'von Willebrand Disease, Type 2', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D014841', 'descriptor_name': 'von Willebrand Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014841', 'descriptor_name': 'von Willebrand Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1160/th13-11-0902', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206235894', 'display_name': 'Thrombosis and Haemostasis', 'issn_l': '0340-6245', 'issn': ['0340-6245', '2567-689X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24598842', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1482004319', 'https://openalex.org/W1484112502', 'https://openalex.org/W1566177450', 'https://openalex.org/W1608373520', 'https://openalex.org/W1966078827', 'https://openalex.org/W1972287241', 'https://openalex.org/W1972897065', 'https://openalex.org/W1980884659', 'https://openalex.org/W1999583938', 'https://openalex.org/W2000612542', 'https://openalex.org/W2007425904', 'https://openalex.org/W2009813742', 'https://openalex.org/W2030858051', 'https://openalex.org/W2042649971', 'https://openalex.org/W2044440492', 'https://openalex.org/W2047248776', 'https://openalex.org/W2052742602', 'https://openalex.org/W2054925281', 'https://openalex.org/W2059004434', 'https://openalex.org/W2067690272', 'https://openalex.org/W2069024266', 'https://openalex.org/W2071254360', 'https://openalex.org/W2079031176', 'https://openalex.org/W2081795547', 'https://openalex.org/W2096067053', 'https://openalex.org/W2099540110', 'https://openalex.org/W2102337014', 'https://openalex.org/W2125023500', 'https://openalex.org/W2137827663', 'https://openalex.org/W2146008626', 'https://openalex.org/W2167096693', 'https://openalex.org/W2171268876', 'https://openalex.org/W2175263209', 'https://openalex.org/W2305034827', 'https://openalex.org/W2394531657', 'https://openalex.org/W2425002376', 'https://openalex.org/W3110701567', 'https://openalex.org/W4247896796'], 'related_works': ['https://openalex.org/W4238361847', 'https://openalex.org/W3109596323', 'https://openalex.org/W2897203814', 'https://openalex.org/W2809160333', 'https://openalex.org/W2757056566', 'https://openalex.org/W2394870424', 'https://openalex.org/W2157610108', 'https://openalex.org/W2119937857', 'https://openalex.org/W2104430226', 'https://openalex.org/W2051832959'], 'abstract_inverted_index': {'The': [0, 158], 'bleeding': [1], 'disorder': [2], 'von': [3, 12], 'Willebrand': [4, 13], 'disease': [5], '(VWD)': [6], 'is': [7], 'caused': [8], 'by': [9, 43, 239], 'mutations': [10, 27, 77, 181], 'of': [11, 107, 111, 186, 200, 205, 220], 'factor': [14], '(VWF),': [15], 'a': [16, 104, 197], 'multimeric': [17], 'glycoprotein': [18], 'essential': [19], 'for': [20, 155, 218, 227], 'platelet-dependent': [21], 'primary': [22], 'haemostasis.': [23], 'VWD': [24, 66, 112, 179, 206, 222, 228], 'type': [25, 207], '2A-associated': [26], 'each': [28, 116], 'disrupt': [29], 'VWF': [30, 40, 63, 73, 81, 170, 187, 232], 'biosynthesis': [31, 130], 'and': [32, 53, 69, 93, 152, 202, 224], 'function': [33, 110], 'at': [34], 'different': [35], 'stages,': [36], 'depending': [37], 'on': [38], 'the': [39, 44, 57, 61, 80, 108, 168, 184], 'domain': [41], 'altered': [42], 'mutation.': [45], 'These': [46], 'effects': [47], 'cause': [48], 'considerable': [49], 'heterogeneity': [50], 'in': [51, 65, 79, 84, 122, 129, 147], 'phenotypes': [52, 159, 223], 'symptoms.': [54], 'To': [55], 'characterise': [56], 'molecular': [58, 94], 'mechanisms': [59], 'underlying': [60], 'specific': [62, 127], 'deficiencies': [64], '2A/IIC,': [67], 'IID': [68], 'IIE,': [70], 'we': [71, 98, 118, 141, 175], 'investigated': [72, 177], 'variants': [74], 'with': [75, 230], 'patient-derived': [76], 'either': [78], 'pro-peptide': [82], 'or': [83, 87], 'domains': [85], 'D3': [86], 'CK.': [88], 'Additionally': [89], 'to': [90, 102, 134, 167, 188], 'static': [91, 240], 'assays': [92, 140], 'dynamics': [95], '(MD)': [96], 'simulations': [97, 174], 'used': [99], 'microfluidic': [100, 139, 212], 'approaches': [101], 'perform': [103], 'detailed': [105], 'investigation': [106], 'shear-dependent': [109, 201, 231], '2A': [113, 208], 'mutants.': [114, 157, 209], 'For': [115], 'group,': [117], 'found': [119], 'distinct': [120], 'characteristics': [121, 146], 'their': [123], 'intracellular': [124], 'localisation': [125], 'visualising': [126], 'defects': [128], 'which': [131], 'are': [132, 235], 'correlated': [133], 'respective': [135], 'multimer': [136], 'patterns.': [137], 'Using': [138], 'further': [142, 176], 'determined': [143], 'shear': [144], 'flow-dependent': [145], 'polymer-platelet-aggregate': [148], 'formation,': [149], 'platelet': [150], 'binding': [151], 'string': [153], 'formation': [154], 'all': [156], 'observed': [160], 'under': [161], 'flow': [162], 'conditions': [163], 'were': [164], 'not': [165, 237], 'related': [166], 'mutated': [169], 'domain.': [171], 'By': [172], 'MD': [173], 'how': [178], '2A/IID': [180], 'might': [182, 214], 'alter': [183], 'ability': [185], 'form': [189], 'carboxy-terminal': [190], 'dimers.': [191], 'In': [192], 'conclusion,': [193], 'our': [194, 211], 'study': [195], 'offers': [196], 'comprehensive': [198], 'picture': [199], 'shear-independent': [203], 'dysfunction': [204], 'Furthermore,': [210], 'assay': [213], 'open': [215], 'new': [216, 221], 'possibilities': [217], 'diagnosis': [219], 'treatment': [225], 'choice': [226], 'patients': [229], 'dysfunctions': [233], 'that': [234], 'currently': [236], 'detectable': [238], 'tests.': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2104430226', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2024-09-16T23:24:44.682969', 'created_date': '2016-06-24'}