Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

Name: Work Video:
Duration: 3 min 30 s
Sophie Leclerc; Matthieu Garnier; Ralph Hoessel; Doris Marko; James Bibb; Gretchen L. Snyder; Paul Greengard; Jacek Biernat; Yong‐Zhong Wu; Eva‐Maria Mandelkow; Gerhard Eisenbrand; Laurent Meijer
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'correlate': [33, 282], 'with': [34, 129, 283, 378, 852, 1261, 1396, 2365, 2692, 2757, 2950, 3076, 3141, 3154, 3188, 3241, 3250, 3296, 3336, 3350, 3418, 3542, 3551, 3624, 3744, 3875, 4062, 4139], 'their': [35, 113, 226, 284, 362, 475, 1952, 3796], 'antimitotic': [36, 227, 285, 476, 1111], 'effects.': [37, 286], 'Indirubins': [38, 161, 235, 287, 410, 484, 1257, 1814], 'were': [39, 121, 288, 370, 2027, 2033, 2040, 2137, 2155, 2169, 2205, 2215, 2222, 2232, 2248, 2255, 2289, 2311, 2382, 2394, 2433, 2472, 2634, 2657, 2661, 2690, 2798, 2816, 2841, 2983, 3060, 3239, 3301, 3348, 3362, 3406, 3516, 3549, 3564, 3577, 3591, 3608, 3742, 3768, 3825, 3986, 4004, 4050, 4082, 4127, 4226], 'recently': [40, 122, 289, 371, 1163, 1745], 'described': [41, 290, 2142, 2887, 2992, 3050, 3484, 3989, 4229], 'potent': [43, 292, 1168, 1425, 1797, 1937], '(IC50:': [44, 61, 293, 310], '50–100': [45, 294, 1291], 'nm)': [46, 63, 295, 312, 1292], 'inhibitors': [47, 60, 208, 211, 222, 243, 296, 309, 457, 460, 471, 492, 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3363, 3517], 'Fig.1).': [598], 'use': [600], 'indigoı̈ds': [602], 'textile': [604], 'dates': [606], 'back': [607], 'Bronze': [610], 'age': [611], '(−7000),': [612], '(now': [615], 'synthetic)': [616], 'abundantly': [620], 'produced': [621], 'dye': [622], 'world': [625], '(blue': [626], 'jeans,': [627], 'denims,': [628], 'etc.)': [629], '(1Hurry': [630], 'J.B.': [631], 'Woad': [633], 'Plant': [634, 669], 'Its': [636, 3042], 'Dye.': [637], 'Oxford': [638], 'University': [639, 2463], 'Press,': [640, 649], 'Oxford,': [641], 'UK1930Google': [642], 'Scholar,': [643, 683, 713, 820, 834, 884, 898, 913, 924, 977, 994, 1009, 1032, 1047, 1063, 1076, 1133, 1147, 1228, 1243, 1551, 1570, 1607, 1722, 2917], '2Balfour-Paul': [644], 'J.': [645, 716, 814, 969, 987, 1003, 1027, 1039, 1055, 1068, 1129, 1141, 1178, 1298, 1356, 1622, 1648, 1670, 1716, 2733, 2908, 2926, 3028, 3120, 3322, 3527, 3886], 'Indigo.': [646], 'British': [647], 'Museum': [648], 'London1998Google': [650], 'Scholar).': [651, 724, 781, 848, 953, 1099, 1161, 1256, 1331, 1389, 1465, 1742, 1789, 1924, 2742, 2941, 3534, 3673, 3894], 'Indigo-producing': [652], 'plants': [653], 'been': [656, 1105], '(3Tang': [662], 'W.': [663, 1084, 1196, 1220, 1316, 1374], 'Eisenbrand': [664, 1197, 1317, 1375], 'G.': [665, 1198, 1221, 1318, 1376, 1576, 3124], 'Drugs': [667], 'Origin:': [670], 'Chemistry,': [671], 'Pharmacology,': [672], 'Use': [674], 'Traditional': [676, 888], 'Modern': [678], 'Medicine.': [679], 'Springer-Verlag,': [680], 'Heidelberg1992Crossref': [681], 'Google': [682, 723, 952, 976, 993, 1046, 1075, 1210, 1242, 1255, 1330, 1388, 1464, 1500, 1524, 1550, 1569, 1585, 1606, 1636, 1655, 1678, 1721, 1741, 1788, 1923, 2741, 2916, 2940, 3139, 3334, 3533, 3672, 3893], '4Lee,': [684], 'H.': [685, 3029], '(1993)': [686], 'Human': [688], 'Medicinal': [689, 1090], 'Agents': [690], 'Plants(Kinghorn,': [692], 'A.': [693, 1086, 1124, 1182, 1302, 1360, 1892, 2892, 2919, 3522, 3641], 'D.,': [694], 'Balandrin,': [696], 'M.': [697, 1065, 1180, 1186, 1300, 1306, 1358, 1364, 1487, 1507, 1533, 1772, 2902, 3464], 'F.,': [698], 'eds)': [699], 'Chapter': [700], '12,': [701, 4098], 'pp.': [702], '170–190,': [703], 'ACS': [704, 2850], 'Symposium': [705], 'Series': [706, 2340], '534,': [707], 'American': [708], 'Chemical': [709, 2437], 'Society,': [710], 'Washington,': [711], 'DC.Google': [712], '5Han': [714], 'R.': [715, 968, 1174, 1294, 1352, 1453, 1596], 'Ethnopharmacol.': [717, 970], '1998;': [718, 971, 1252, 1458, 1494, 1582, 1651, 1730], '24:': [719, 972], '1-17Crossref': [720, 973], 'Scopus': [721, 950, 974, 1208, 1240, 1328, 1386, 1462, 1498, 1522, 1548, 1567, 1604, 1634, 1676, 1739, 1786, 1921, 2739, 2914, 2938, 3137, 3332, 3670, 3891], '(56)': [722, 975, 2939], 'well-studied': [726], 'example': [727], 'mixture': [733], '11': [735], 'herbal': [736], 'medicines': [737], 'traditionally': [738], 'utilized': [739], 'certain': [741], 'types': [742], 'Only': [745], 'ingredients,': [749], 'Qing': [750], 'Dai': [751], 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980], 'Medical': [811, 984], 'Sciences': [812, 985], 'Intern.': [815, 988, 1004], 'Med.': [816, 830, 844, 989, 1005, 1042, 1059, 1071, 1128, 1156], '1979;': [817, 831, 845, 990], '86-88Google': [819], '8Chen': [821], 'D.W.': [822], 'Li': [823], 'Y.F.': [824], 'Ye': [825], 'H.P.': [826], 'Comm.': [827, 841], '10:': [832, 1519, 1545, 3329], '7-9Google': [833], '9Wu': [835], 'L.M.': [836], 'Yang': [837, 1012], 'Y.P.': [838], 'Zhu': [839, 937], 'Z.H.': [840], '9:': [846, 3888], 'Preclinical': [849], 'studies': [850, 3931, 4200], 'performed': [851, 2156, 2233, 2335, 2691, 3453], 'more': [855], 'soluble': [856], 'analogues,': [857], 'confirmed': [858], 'compounds': [861, 2154, 2204, 2381, 3814, 4097], 'exhibit': [862], 'good': [863], 'antitumor': [864], 'toxicity': [869], '(10Ji': [870], 'X.J.': [871, 915], 'Zhang': [872, 916], 'F.R.': [873, 917, 1641], 'Lei': [874], 'J.L.': [875], 'Xu': [876], 'Y.T.': [877, 1902, 3651], 'Acta': [878, 907, 918, 1154], 'Pharm.': [879, 908, 919], 'Sin.': [880, 909, 920, 1143, 1157], '1981;': [881, 895, 910], '16:': [882], '146-148Google': [883], '11Sichuan': [885], 'Institute': [886, 2459], 'Herb': [893], '12:': [896, 1495], '27-29Google': [897], '12Wang': [899], 'J.H.': [900], 'You': [901], 'Y.C.': [902], 'Mi': [903], 'Ying': [905], 'H.G.': [906], '2:': [911], '241-244Google': [912], '13Ji': [914], '1985;': [921, 1029, 1043, 1060, 1158], '20:': [922], '137-139Google': [923], '14Li': [925], 'C.': [926, 1505, 1531, 1574, 1580], 'Go': [927], 'Y.': [928, 934], 'Mao': [929], 'Z.': [930, 940, 1019, 1894, 3643], 'Koyano': [931], 'K.': [932, 1451, 1713, 2725], 'Kai': [933], 'Kaneshisa': [935], 'N.': [936, 1663, 2900, 3122], 'Q.': [938], 'Zhou': [939], 'Wu': [941, 1022, 1150], 'S.': [942, 1176, 1296, 1354, 1665, 1669, 1776, 2923], 'Bull.': [943], 'Chem.': [944, 1624, 2928], 'Soc.': [945, 1597], 'Jpn.': [946], '1996;': [947, 1518, 1544], '69:': [948], '1621-1627Crossref': [949], '(27)': [951, 1984], 'Clinical': [954, 998], 'trials': [955], 'showed': [956, 1276], 'has': [959], 'definite': [961], 'efficiency': [962], 'myelocytic': [965], 'leukemia': [966], '(5Han': [967], '15Institute': [978], '18:': [991], '83-88PubMed': [992], '16Cooperative': [995], 'Group': [996], 'Therapy': [999], 'Indirubin': [1001, 2045], '1980;': [1006, 1130], '1:': [1007, 1205, 1325, 1383], '132-135Google': [1008], '17Gan': [1010], 'W.J.': [1011], 'T.Y.': [1013], 'Wen': [1014], 'S.D.': [1015], 'Liu': [1016, 1024, 1035, 1050, 1121, 1136], 'Y.Y.': [1017], 'Tan': [1018], 'Deng': [1020], 'C.A.': [1021], 'M.P.': [1025], 'Hematol.': [1028], '6:': [1030], '611-613Google': [1031], '18Zhang': [1033], 'Z.N.': [1034, 1049], 'E.K.': [1036, 1051], 'Zheng': [1037, 1052], 'T.L.': [1038, 1053], '5:': [1044, 1061], '246-248PubMed': [1045], '19Zhang': [1048], 'Integrated': [1056], 'Western': [1058, 3280], '80-82Google': [1062], '20Ma': [1064], 'Yao': [1066], 'B.': [1067, 3053, 3739, 4046], 'Tradit.': [1069], '1983;': [1072], '3:': [1073], '245-248PubMed': [1074], '21Chang': [1077], 'C.N.': [1078], 'Chang': [1079, 1123], 'H.M.': [1080], 'Yeung': [1081], 'H.W.': [1082], 'Tso': [1083], 'Koo': [1085], 'Advances': [1087], 'Materials': [1091], 'Research.': [1092], 'World': [1093], 'Scientific': [1094], 'Publishing': [1095], 'Company,': [1096], 'Singapore1985:': [1097], '369-376Google': [1098], 'Several': [1100], 'mechanisms': [1101], 'action': [1103, 1588], 'brought': [1106], 'forward': [1107], 'explain': [1109], '(22Wu': [1117], 'G.Y.': [1118, 1135, 1151], 'Fang': [1119, 1138], 'F.D.': [1120, 1139], 'J.Z.': [1122, 1137], 'Ho': [1125], 'Y.H.': [1126], '60:': [1131], '451-454Google': [1132], '23Wu': [1134], 'Zuo': [1140], 'Sci.': [1142, 1599, 1650], '1982;': [1144], '25:': [1145], '1071-1079Google': [1146], '24Zhang': [1148], 'L.': [1149, 1200, 1320, 1378, 1770, 1896, 2890, 2925, 3645], 'Qiu': [1152], 'C.C.': [1153], 'Acad.': [1155], '7:': [1159], '112-116Google': [1160], '(CDKs)1(25Hoessel': [1173], 'Leclerc': [1175, 1295, 1353], 'Endicott': [1177, 1297, 1355], 'Noble': [1179, 1299, 1357], 'Lawrie': [1181, 1301, 1359], 'Tunnah': [1183, 1303, 1361], 'P.': [1184, 1304, 1362, 1593, 1778, 1915, 2485, 2729, 3526, 3664], 'Leost': [1185, 1305, 1363], 'Damiens': [1187, 1307, 1365], 'E.': [1188, 1194, 1308, 1314, 1366, 1372, 1511, 1537, 1726, 3128], 'Marie': [1189, 1309, 1367], 'D.': [1190, 1192, 1230, 1310, 1312, 1368, 1370, 1513, 1539], 'Marko': [1191, 1311, 1369], 'Niederberger': [1193, 1313, 1371], 'Tang': [1195, 1315, 1373], 'Meijer': [1199, 1319, 1377, 1895, 2924, 3644], 'Nat.': [1201, 1321, 1379], 'Cell': [1202, 1233, 1322, 1380, 1649, 1728, 3360], 'Biol.': [1203, 1235, 1323, 1381, 1623, 1729, 2927, 3326], '1999;': [1204, 1324, 1382, 1600, 1625, 1672, 1782, 1917, 2929, 3328, 3666], '60-67Crossref': [1206, 1326, 1384], 'PubMed': [1207, 1239, 1327, 1385, 1461, 1497, 1521, 1547, 1566, 1603, 1633, 1654, 1675, 1738, 1785, 1920, 2738, 2913, 2937, 3136, 3331, 3532, 3669, 3890], '(751)': [1209, 1329, 1387], 'Scholar),': [1211, 1525, 1586, 1637, 1656, 1679], 'key': [1215], 'cell': [1216, 1474, 3236, 3319], 'cycle': [1217, 1475], 'regulators': [1218], '(26Dunphy,': [1219], '(ed)': [1222], '(1997)': [1223], 'Methods': [1224], 'Enzymol.': [1225], '283,': [1226], '1-67Google': [1227], '27Morgan': [1229], 'Annu.': [1231], 'Rev.': [1232], 'Dev.': [1234, 1457, 1493, 1517, 1543], '1997;': [1236, 1718, 2910, 3529], '13:': [1237], '261-291Crossref': [1238], '(1834)': [1241], '28Vogt': [1244], 'P.K.': [1245], 'Reed': [1246], 'S.I.': [1247], 'Curr.': [1248, 1454], 'Top.': [1249], 'Microbiol.': [1250], 'Immunol.': [1251], '227:': [1253], '1-169PubMed': [1254], 'act': [1258], 'competing': [1260], 'catalytic': [1267], 'site': [1268], 'kinase.': [1271], 'selectivity': [1274, 1412, 3701], 'strong': [1281], 'affinity': [1282, 2873, 3019], 'CDKs': [1284, 1959, 3859, 3880, 4049, 4126], '(IC50': [1285, 1344, 1427], 'values': [1286, 1345, 1428, 2282, 2656, 3767, 3821, 3830, 4003, 4076, 4087], 'range': [1289], '(25Hoessel': [1293, 1351], 'Nevertheless,': 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[1476], 'controlling': [1478], 'levels': [1480, 3311], 'cyclin': [1482], 'D1': [1483], '(30Diehl': [1484], 'J.A.': [1485, 1888, 3637], 'Cheng': [1486], 'Roussel': [1488], 'M.F.': [1489], 'Sherr': [1490], 'C.J.': [1491], 'Genes': [1492, 1516, 1542], '3499-3511Crossref': [1496], '(1882)': [1499], 'Scholar)': [1501, 3140], 'β-catenin': [1503], '(31Yost': [1504, 1530], 'Torres': [1506, 1532], 'Miller': [1508, 1534], 'J.R.': [1509, 1535, 2731], 'Huang': [1510, 1536], 'Kimelman': [1512, 1538], 'Moon': [1514, 1540], 'R.T.': [1515, 1541], '1443-1454Crossref': [1520, 1546], '(1034)': [1523, 1549], 'dorsal-ventral': [1526], 'patterning': [1527], 'development': [1529], '32He': [1552], 'X.': [1553], 'Saint-Jeannet': [1554], 'J.-P.': [1555], 'Woodgett': [1556, 2730], 'H.E.': [1557, 1559], 'Varmus': [1558], 'Dawid': [1560], 'I.B.': [1561], 'Nature.': [1562, 1781, 1916, 3665], '1995;': [1563, 3887], '374:': [1564], '617-622Crossref': [1565], '(452)': [1568], '33Emily-Fenouil': [1571], 'F.': [1572], 'Ghiglione': [1573], 'Lhomond': [1575], 'Lepage': [1577], 'T.': [1578, 1715, 3884], 'Gache': [1579], 'Development.': [1581], '125:': [1583], '2489-2498PubMed': [1584], 'insulin': [1587], 'synthesis': [1591], '(34Cohen': [1592], 'Philos.': [1594], 'Trans.': [1595], 'Lond-Biol.': [1598], '354:': [1601], '485Crossref': [1602], '(140)': [1605], '35Summers': [1608], 'S.A.': [1609], 'Kao': [1610], 'A.W.': [1611], 'Kohn': [1612], 'A.D.': [1613], 'Backus': [1614], 'G.S.': [1615], 'Roth': [1616], 'R.A.': [1617], 'Pessin': [1618], 'J.E.': [1619], 'Birnbaum': [1620], 'M.J.': [1621], '274:': [1626, 2930], '17934-17940Abstract': [1627], 'Full': [1628, 1630, 1733, 1735, 2932, 2934, 3133], 'Text': [1629, 1631, 1734, 1736, 2933, 2935, 3134], 'PDF': [1632, 1737, 2936, 3135], '(199)': [1635], 'axonal': [1638], 'outgrowth': [1639, 3317], '(36Lucas': [1640], 'Goold': [1642], 'R.G.': [1643], 'Gordon-Weeks': [1644], 'P.R.': [1645], 'Salinas': [1646], 'P.C.': [1647], '111:': [1652], '1351-1361Crossref': [1653], 'HIV-1': [1657], 'Tat-mediated': [1658], 'neurotoxicity': [1659], '(37Maggirwar': [1660], 'S.B.': [1661], 'Tong': [1662], 'Ramirez': [1664], 'Gelbard': [1666], 'H.A.': [1667], 'Dewhurst': [1668], 'Neurochem.': [1671], '73:': [1673], '578-586Crossref': [1674], '(151)': [1677], 'among': [1680], 'others.': [1681], 'Furthermore,': [1682, 1801], 'filaments,': [1704], 'diagnostic': [1707], '(AD)': [1711], '(38Imahori': [1712], 'Uchida': [1714], 'Biochem.': [1717, 2734, 2909], '121:': [1719], '179-188PubMed': [1720], '39Mandelkow': [1723], 'E.-M.': [1724, 3126, 3324], 'Mandelkow': [1725, 3125, 3127, 3323], 'Trends': [1727], '425-427Abstract': [1732], '(445)': [1740], 'demonstrated': [1746], 'conversion': [1748], 'p35,': [1750, 3037], 'regulatory': [1752], 'subunit': [1753], 'truncated': [1758, 3034], 'form,': [1759], 'p25,': [1760], 'deregulates': [1761], 'promotes': [1765], 'neurodegeneration': [1766], '(40Patrick': [1767], 'G.N.': [1768], 'Zukerberg': [1769], 'Nikolic': [1771], 'De': [1773], 'la': [1774], 'Monte': [1775], 'Dikkes': [1777], 'Tsai': [1779, 1899, 3648], 'L.H.': [1780], '402:': [1783, 1918, 3667], '615-622Crossref': [1784], '(1343)': [1787], 'CDK5/p25.': [1800], 'indirubin-3′-monoxime': [1802, 1840, 2073, 3289, 3477, 3555], 'vivoat': [1810], 'lead': [1819], 'compound': [1820, 3715, 3903, 3913, 3919, 3928, 4180, 4187, 4197], 'disorders': [1828], 'involving': [1829, 2150], '(“taupathies”).': [1834], 'CDK5.': [1846], 'striatum': [1850], 'acting': [1852], 'downstream': [1853], 'action,': [1856], 'either': [1859], 'phosphorylated': [1860, 3633], 'Thr-34': [1862], 'cAMP-dependent': [1864], '(PKA)': [1867], '(it': [1868, 1881], 'then': [1869, 1882, 3390], 'acts': [1870], 'phosphatase': [1873], '1': [1874, 2513, 2516, 2520, 2522, 2546, 2549, 2611, 2617, 2751, 2779, 2847, 2951, 2964], 'inhibitor)': [1875, 1886], 'Thr-75': [1878, 3635], 'becomes': [1883], 'PKA': [1885], '(41Bibb': [1887, 3636], 'Snyder': [1889, 3523, 3638], 'G.L.': [1890, 3524, 3639], 'Nishi': [1891, 3640], 'Yan': [1893, 3642], 'Fienberg': [1897, 3646], 'A.A.': [1898, 3647], 'L.-H.': [1900, 3649], 'Kwon': [1901, 3650], 'Girault': [1903, 3652], 'J.-A.': [1904, 3653], 'Czernik': [1905, 3654], 'A.J.': [1906, 3655], 'Huganir': [1907, 3656], 'R.L.': [1908, 3657], 'Hemmings': [1909, 3658], 'Jr.,': [1910, 3659], 'H.C.': [1911, 3660], 'Nairn': [1912, 3661], 'A.C.': [1913, 2921, 3662], 'Greengard': [1914, 3525, 3663], '669-671Crossref': [1919, 3668], '(498)': [1922, 3671], 'Whether': [1940], 'antimitotic/antitumoral': [1942], '(and': [1946], 'other': [1947, 2023, 3833, 4090], 'inhibitors)': [1949], 'derive': [1950], 'dual': [1953], 'inhibitory': [1954, 3681, 4037], 'Indigo': [1964], '(2)': [1965], '(Fluka),': [1966, 1969, 1975, 1981, 1985, 1994, 2004, 2017, 2021], '(3)': [1968], '5,5′,7,7′-indigotetrasulfonic': [1970], 'potassium': [1972, 1978], 'salt': [1973, 1979, 2001], '(25)': [1974], '5,5′,7-indigotrisulfonic': [1976], '(26)': [1980], 'carmine': [1983], '5-chloroisatin': [1986], '(30)': [1987], '(Lancaster),': [1988, 2013], '5-fluoroisatin': [1989], '(29)': [1990], '(Aldrich),': [1991], '5-bromoisatin': [1992], '(31)': [1993], '5-methylisatin': [1995], '(32)': [1996], '(Sigma),': [1997], 'isatin-5-sulfonic': [1998, 2108, 2112, 2126, 2130], 'sodium': [2000, 2411, 2518], 'dihydrate': [2002], '(33)': [2003], '5-nitroisatin': [2005], '(34)': [2006], '(Acros),': [2007, 2010], '1-methylisatin': [2008], '(35)': [2009], '1-phenylisatin': [2011], '(36)': [2012], 'acetate': [2015, 2019], '(43)': [2016], '5-bromoindoxyl': [2018], '(44)': [2020], 'solvents': [2024], 'reagents': [2026], 'obtained': [2028, 2434, 2443, 2473, 2492, 3091, 3099], 'commercial': [2030], 'suppliers.': [2031], 'They': [2032, 2393], 'least': [2035, 2822], 'reagent': [2037], 'grade': [2038], 'without': [2042], 'further': [2043, 3696, 3729], 'purification.': [2044], '(1),': [2046], '5-iodoindirubin': [2047], '(4),': [2048], '5-bromoindirubin': [2049], '(5),': [2050], '5-chloroindirubin': [2051], '(6),': [2052], '5-fluoroindirubin': [2053], '(7),': [2054], '5-methylindirubin': [2055], '(8),': [2056], '5-nitroindirubin': [2057], '(9),': [2058], 'indirubin-5-sulfonic': [2059, 2090, 2094, 2098, 2102], '(sodium': [2061, 2070, 2085], 'salt)': [2062, 2071, 2086], '(10),': [2063], '5′-bromoindirubin': [2064], '(11),': [2065], '5,5′-dibromoindirubin': [2066], '(12),': [2067], '5′-bromoindirubin-5-sulfonic': [2068], '(13),': [2072], '(14),': [2074], '5-iodoindirubin-3′-oxime': [2075], '(15),': [2076], '6-iodoindirubin': [2077], '(16),': [2078], '1-methylindirubin': [2079], '(17),': [2080], '1-phenylindirubin': [2081], '(18),': [2082], '3′-hydroxyiminoindirubin-5-sulfonic': [2083], '(19),': [2087], 'indirubin-5-sulfonamide': [2088], '(20),': [2089], 'dimethylamide': [2092, 2110], '(21),': [2093], '(2-hydroxyethyl)amide': [2096, 2128], '(22),': [2097], 'bis-(2-hydroxyethyl)amide': [2100, 2114], '(23),': [2101], 'methylamide': [2104, 2132], '(24),': [2105], '5-iodoisatin': [2106], '(28),': [2107], '(37),': [2111], '(38),': [2115], '6-iodoisatin': [2116], '(39),': [2117], 'isoindigo': [2118], '(40),': [2119], '2,2′-bi-indole': [2120], '(41),': [2121], '3,3′-diphenyl-2,2′-bi-indole': [2122], '(42),': [2123], 'isatin-5-sulfonamide': [2124], '(45),': [2125], '(46),': [2129], '(47),': [2133], '2-hydroxyimino-N-(3-iodophenyl)acetamide': [2135], '(48)': [2136], 'synthesized': [2138, 2453, 3686], 'purified': [2140, 2719, 2871, 3017, 3218, 3455, 3734], 'Supplementary': [2145], 'material': [2146], 'section.': [2147], 'Synthesis': [2148, 2457], 'reactions': [2149], 'oxygen': [2151], 'moisture-sensitive': [2153], 'under': [2157, 2318, 3479, 3990, 4230], 'dry': [2159], 'argon': [2160], 'atmosphere.': [2161], 'All': [2162, 2380], 'reaction': [2163, 3488], 'mixtures': [2164], 'column': [2166, 2349], 'chromatographic': [2167], 'fractions': [2168], 'analyzed': [2170], 'thin': [2172], 'layer': [2173], 'chromatography': [2174, 2186, 2874, 3020], 'plates': [2176], '(Alugram': [2177], 'Sil': [2178], 'G/UV254,': [2179], 'purchased': [2180], 'Macherey': [2182, 2196], '&': [2183, 2197], 'Nagel).': [2184, 2198], 'Column': [2185], 'carried': [2188], 'out': [2189], 'using': [2190, 2234, 2271, 2324, 2336, 3219, 3257, 3439, 3454, 3518, 3597, 3612, 4052, 4129], 'Silica': [2191], 'Gel': [2192], '60': [2193, 2497, 3561], '(0.063–0.2': [2194], 'mm,': [2195], 'Melting': [2199, 2217], 'points': [2200, 2218], 'non-indigoı̈d': [2203], 'determined': [2206, 2223, 3592, 4080], 'Büchi': [2209], '510': [2210], 'melting': [2211], 'point': [2212], 'apparatus': [2213], 'uncorrected.': [2216], 'over': [2219], '260': [2220], '°C': [2221, 2371, 2377, 3064], 'Wagner': [2226], 'Munz': [2228], 'Kupferblock.': [2229], 'Elemental': [2230], 'analyses': [2231], '2400': [2236], 'CHN': [2237], 'elemental': [2238], 'analyzer': [2239], '(PerkinElmer': [2240], 'Life': [2241], 'Sciences).': [2242], 'Unless': [2243], 'otherwise': [2244, 2642], 'indicated,': [2245], 'NMR': [2246, 2253, 2261], 'spectra': [2247, 2254, 2262, 2310], 'recorded': [2249, 2256], 'room': [2251], 'temperature.1H': [2252], '400': [2258], 'MHz,': [2259], '13C': [2260], '100': [2264, 2537, 2624], 'MHz': [2265], 'Bruker': [2268], 'AMX': [2269], '400,': [2270], 'tetramethylsilane,': [2272], 'Me2SO': [2274], '(δ': [2275], '=': [2276, 2353], '39.4': [2277], 'ppm)': [2278], 'internal': [2280], 'standard.J': [2281], 'hertz.': [2286], 'Apparent': [2287], 'multiplicities': [2288], 'designated': [2290], 's,': [2292], 'singlet;': [2293], 'd,': [2294], 'doublet;': [2295, 2298], 'dd,': [2296], 'double': [2297], 't,': [2299], 'triplet;': [2300], 'pt,': [2301], 'pseudo-triplet;': [2302], 'q,': [2303], 'quartet;': [2304], 'm,': [2305], 'multiplet;': [2306], 'b,': [2307], 'broad.': [2308], 'Mass': [2309], 'taken': [2312], 'positive': [2315], 'ion': [2316], 'mode': [2317], '(EI': [2321], '70': [2322], 'eV)': [2323], 'Finnigan': [2326], 'MAT': [2327], '90': [2328], 'mass': [2329], 'spectrometer.': [2330], 'Gas': [2331], 'chromatography/mass': [2332], 'spectrometry': [2333], 'Hewlett-Packard,': [2338, 2360], '5890': [2339], 'II': [2341], 'gas': [2342], 'chromatograph': [2343], '25-m': [2346], 'fused': [2347], 'silica': [2348], '(Hewlett-Packard': [2350], 'HP-5,': [2351], 'I.D.': [2352], '0.25': [2354, 2356], 'mm;': [2355], 'μm)': [2357], 'HP': [2361], '5971A': [2362], 'mass-selective': [2363], 'detector': [2364], 'following': [2367, 2746, 3420], 'temperature': [2368], 'program:': [2369], '80': [2370], '(4': [2372], 'min),': [2373], '25': [2374, 2502, 2552], '°/min,': [2375], '320': [2376], '(16.4': [2378], 'min).': [2379], 'dissolved': [2383], 'stored': [2385], '10': [2387, 2525, 2528, 2531, 2544, 2754, 2831, 3393, 3557], 'mm': [2388, 2500, 2503, 2508, 2511, 2514, 2517, 2523, 2547, 2550, 2553, 2568, 2581, 2586, 2597, 2602, 2609, 2612, 2615, 2618, 2755, 3587], 'stock': [2389], 'solutions': [2390], 'Me2SO.': [2392], 'diluted': [2395], 'aqueous': [2397], 'buffers': [2398], 'just': [2399], 'prior': [2400], 'use.': [2401], 'Sodium': [2402], 'orthovanadate,': [2403, 2619], 'EGTA,': [2404, 2509, 2548, 2569, 2613], 'EDTA,': [2405], 'RNase': [2406], 'A,': [2407, 2770], 'Mops,': [2408], 'β-glycerophosphate,': [2409], 'phenylphosphate,': [2410, 2524], 'fluoride,': [2412], 'glutathione-agarose,': [2413], '(DTT),': [2415], '(BSA),': [2419], 'nitrophenylphosphate,': [2420], 'leupeptin,': [2421, 2527, 2628], 'aprotinin,': [2422, 2530, 2629], 'pepstatin,': [2423], 'soybean': [2424, 2533], 'trypsin': [2425, 2534], 'inhibitor,': [2426, 2535], 'benzamidine,': [2427], 'histone': [2429, 2953, 3752, 4057, 4134], 'H1': [2430, 4058, 4135], '(type': [2431], 'III-S)': [2432], 'Sigma': [2436], 'Co.': [2438], '[γ-32P]ATP': [2439, 2961], '(PB': [2440], '168)': [2441], 'Amersham': [2445], 'Pharmacia': [2446, 2852, 3445], 'Biotech.': [2447], 'GS-1': [2449, 2763, 4054, 4131], 'peptide': [2450, 2764, 4055, 4132], '(YRRAAVPPSPSLSRHSSPHQSpEDEEE)': [2451], 'Peptide': [2456], 'Unit,': [2458], 'Biomolecular': [2461], 'Sciences,': [2462], 'Southampton,': [2465], 'UK.': [2466], 'AT-8,': [2467], 'AT-180,': [2468], 'AT-100': [2470, 3426], 'antibodies': [2471], 'Innogenetics,': [2475], 'SA,': [2476], 'Ghent,': [2477], 'Belgium,': [2478], 'PHF-1': [2479, 3428], 'gift': [2482], 'Dr.': [2484, 3027, 3463], 'Davies': [2486], '(Bronx,': [2487], 'NY),': [2488], 'K9JA': [2490], 'Dako': [2494], '(Hamburg,': [2495], 'Germany).': [2496, 3223, 3448], 'mmβ-glycerophosphate,': [2498], '15': [2499, 2507, 2510, 2653, 2775, 2959, 3401, 3758, 4063, 4140], 'p-nitrophenylphosphate,': [2501], 'Mops': [2504], '(pH': [2505], '7.2),': [2506], 'MgCl2,': [2512], 'DTT,': [2515, 2551, 2610, 2756], 'vanadate,': [2519], 'mmNaF,': [2521], 'μg/ml': [2526, 2529, 2532, 2558, 2625, 3083, 3087], 'benzamidine.': [2539], 'Buffer': [2540, 2560, 2637], 'consisted': [2542, 2562, 2578, 2594], 'mmMgCl2,': [2545], 'Tris-HCl,': [2554, 2598], 'pH': [2555, 2583, 2599], '7.5,': [2556], '50': [2557, 2580, 2596, 3082, 3586], 'heparin.': [2559], 'C': [2561, 2640, 3048], 'homogenization': [2564, 2861], '5': [2567, 2608, 2620, 2758, 2823, 3274], 'no': [2570, 2573], 'NaF,': [2571, 2616], 'protease': [2574], 'Tris,': [2582], '7.4,': [2584, 2600], '150': [2585], 'NaCl,': [2587, 2603], '0.1%': [2589], 'Tween': [2590], '20.': [2591], 'HLB': [2592], '120': [2601], '10%': [2604, 3077, 3501], 'glycerol,': [2605], '1%': [2606, 3583], 'Nonidet-P40,': [2607], '20': [2614, 2811, 3337], 'microcystin,': [2622], 'each': [2626, 2825, 3823, 4078], 'pepstatin.': [2631], 'Kinase': [2632, 3740], 'activities': [2633, 2660, 2673, 3741, 3985, 4225], 'assayed': [2635, 2946, 3045, 3743, 3987, 4051, 4128, 4227], '(unless': [2641], 'stated),': [2643], '30': [2645, 2786, 2792, 2971, 2977], '°C,': [2646, 2793, 2978], 'final': [2649, 2783, 2968], 'concentration': [2651, 3383], 'μm.': [2654], 'Blank': [2655], 'subtracted,': [2658], 'calculated': [2662, 3769, 4005], 'picomoles': [2664], 'phosphate': [2666, 3260], 'incorporated': [2667], '10-min': [2670, 2974], 'incubation.': [2671], 'usually': [2675], 'expressed': [2676, 2716, 3007, 3310], 'percentage': [2678, 4157], 'maximal': [2681, 4159], 'activity,': [2682], 'i.e.': [2683], 'absence': [2686], 'Controls': [2689], 'appropriate': [2693, 3746], 'dilutions': [2694], 'dimethyl': [2696], 'sulfoxide.': [2697], 'In': [2698, 3674], 'cases': [2701], 'substrate': [2705, 3747], 'assessed': [2707], 'autoradiography': [2709], 'after': [2710], 'SDS-PAGE': [2711, 3278, 3611], 'below).': [2713, 3723], 'insect': [2721], 'Sf9': [2722, 3054, 3224, 3293, 3346], 'cells': [2723, 3055, 3225, 3232, 3273, 3294, 3307, 3347], '(42Hughes': [2724], 'Pulverer': [2726], 'B.J.': [2727], 'Theocharous': [2728], 'Eur.': [2732, 2907], '1992;': [2735], '203:': [2736], '305-311Crossref': [2737], '(59)': [2740], 'assayed,': [2745], '1/100': [2748], 'dilution': [2749], 'mg/ml': [2752, 2952], 'BSA,': [2753], 'μl': [2759], '40': [2761], 'substrate,': [2767], 'μm[γ-32P]ATP': [2776], '(3000': [2777, 2962], 'Ci/mmol;': [2778, 2963], 'mCi/ml)': [2780, 2965], 'volume': [2784, 2969], 'μl.': [2787, 2972], 'After': [2788, 2973, 3369, 3469], '30-min': [2789, 3470], 'incubation': [2790, 2975, 3471], '25-μl': [2794, 2979], 'aliquots': [2795, 2980], 'supernatant': [2797, 2982, 3377], 'spotted': [2799, 2984], 'onto': [2800, 2985], '2.5-': [2801], '×': [2802, 3230, 3374], '3-cm': [2803], 'pieces': [2804], 'Whatman': [2806], 'P81': [2807, 2986], 'phosphocellulose': [2808, 2987], 'paper,': [2809], 'and,': [2810], 's': [2812], 'later,': [2813], 'filters': [2815, 2840], 'washed': [2817], 'five': [2818], 'times': [2819], '(for': [2820], 'min': [2824, 3394, 3562], 'time)': [2826], 'solution': [2829], 'ml': [2832, 2848], 'phosphoric': [2834], 'acid/liter': [2835], 'water.': [2837], 'wet': [2839], 'counted': [2842], '(Amersham': [2851, 3444], 'Biotech)': [2853], 'scintillation': [2854], 'fluid.': [2855], 'B': [2857, 4121], 'extracted': [2859], 'M': [2864], 'phase': [2865], 'starfish': [2866], '(Marthasterias': [2867], 'glacialis)': [2868], 'oocytes': [2869], 'p9CKShs1-Sepharose': [2876], 'beads,': [2877], 'eluted': [2882], 'free': [2884], 'p9CKShs1': [2885], 'previously': [2888], '(43Meijer': [2889], 'Borgne': [2891], 'Mulner': [2893], 'O.': [2894], 'Chong': [2895], 'J.P.J.': [2896], 'Blow': [2897], 'J.J.': [2898], 'Inagaki': [2899, 2901], 'Delcros': [2903], 'J.G.': [2904], 'Moulinoux': [2905], 'J.P.': [2906], '243:': [2911], '527-536Crossref': [2912], '(1222)': [2915], '44Borgne': [2918], 'Ostvold': [2920], 'Flament': [2922], '11977-11986Abstract': [2931], 'C,': [2949], 'H1,': [2954], 'papers': [2988], 'treated': [2990, 3302, 3550], 'above.': [2993], 'reconstituted': [2996, 3203], 'mixing': [2998], 'equal': [2999], 'amounts': [3000, 3603], 'recombinant': [3002, 3266, 3351, 3458], 'mammalian': [3003], 'p25': [3006], 'Escherichia': [3009], 'coli': [3010], 'glutathione': [3012], 'S-transferase': [3013], 'fusion': [3014], 'proteins': [3015], 'glutathione-agarose': [3022], '(vectors': [3023], 'kindly': [3024], 'provided': [3025], 'Wang).': [3030], '(p25': [3031], 'version': [3035], '35-kDa': [3039], 'activator.)': [3041], '(Invitrogen,': [3056], 'San': [3057], 'Diego,': [3058, 3095], 'CA)': [3059], 'grown': [3061, 3226], '27': [3063], 'monolayer': [3066], 'culture': [3067, 3237], "Grace's": [3068], 'medium': [3069], '(Life': [3070], 'Technologies,': [3071], 'Inc.,': [3072], 'Gaithersburg,': [3073], 'MD)': [3074], 'supplemented': [3075], 'fetal': [3078], 'gentamicin': [3084], '2.5': [3086], 'amphotericin.': [3088], 'BaculoGold': [3089, 3160, 3171, 3186, 3247], 'PharMingen': [3093], '(San': [3094], 'CA),': [3096], 'pVL1392': [3097, 3152, 3254], 'Invitrogen.': [3101], 'gene': [3103], 'htau23,': [3105], 'shortest': [3107], 'human': [3108, 3459], 'isoform,': [3110], 'excised': [3112], 'bacterial': [3115], 'expression': [3116], 'vector': [3117, 3151, 3193, 3251], 'pNG2': [3118], '(45Biernat': [3119], 'Gustke': [3121], 'Drewes': [3123], 'Neuron.': [3129], '1993;': [3130], '11:': [3131], '153-163Abstract': [3132], '(674)': [3138], 'XbaI': [3142], 'BamHI': [3144], 'inserted': [3146], 'into': [3147], 'baculovirus': [3149, 3178, 3191, 3242, 3297], 'transfer': [3150, 3192], 'cut': [3153], 'same': [3156, 3572], 'restriction': [3157], 'endonucleases.': [3158], 'system': [3161, 3443], 'construct': [3165], 'baculovirus-containing': [3168], 'vector.': [3169], 'DNA': [3172, 3187, 3201, 3213, 3243], 'modified': [3175], 'type': [3176], 'containing': [3179], 'lethal': [3181, 3196], 'deletion.': [3182], 'Cotransfection': [3183], 'complementing': [3190], 'rescued': [3194], 'deletion': [3197], 'this': [3199, 3714, 3950], 'virus': [3200, 3205, 3352], 'viable': [3204], 'particles': [3206], 'carrying': [3207], 'htau23': [3209, 3299], 'coding': [3210], 'sequence.': [3211], 'Plasmid': [3212], 'transfections': [3216], 'Qiagen': [3220], 'cartridges': [3221], '(Hilden,': [3222], 'monolayers': [3228], '(2': [3229, 3255], '106': [3231], '60-mm': [3235], 'dish)': [3238], 'cotransfected': [3240], '(0.5': [3244], 'μg': [3245], 'DNA)': [3248], 'derivatives': [3252, 3691], 'μg)': [3256, 3405, 3607], 'calcium': [3259], 'coprecipitation': [3261], 'method.': [3262], 'examined': [3269], 'infected': [3272, 3295, 3349], 'days': [3275], 'post-infection': [3276, 3305], 'blotting.': [3281], 'determine': [3283], 'aminopurvalanol': [3287], 'phosphorylation,': [3292], 'expressing': [3298], '36': [3303], 'h': [3304, 3342], '(when': [3306], 'already': [3309], 'sufficient': [3314], 'processes': [3320], '(46Biernat': [3321], 'Mol.': [3325], 'Cell.': [3327], '727-740Crossref': [3330], '(115)': [3333], 'Scholar))': [3335], '3': [3341], 'before': [3343], 'being': [3344], 'harvested.': [3345], 'multiplicity': [3355], 'infection': [3357], '1–5.': [3359], 'lysates': [3361], '(HLB).': [3368], '15-min': [3370], 'centrifugation': [3371], '16,000': [3373, 3398], 'g,': [3375], 'recovered': [3379], 'its': [3381, 3504], 'NaCl': [3382], 'raised': [3384], '500': [3386], 'mm.': [3387], 'boiled': [3391], 'recentrifuged': [3396], '×g': [3399], 'min.': [3402], 'Proteins': [3403], '(3': [3404], 'resolved': [3407, 3499], 'SDS-PAGE,': [3409, 3502], 'transferred': [3410, 3618], 'polyvinylidene': [3413], 'difluoride': [3414], 'membrane,': [3415, 3621], 'Western-blotted': [3417], 'antibodies:': [3421], 'AT-8': [3422], '(1:2000),': [3423], 'AT-180': [3424], '(1:1000),': [3425, 3427], '(1:600),': [3429], 'polyclonal': [3431], 'anti-tau': [3432], 'antibody': [3433, 3628], 'K9JA.': [3434], 'immunostaining': [3436], 'visualized': [3438, 3508], 'ECL': [3441], 'chemiluminescence': [3442], 'Biotech,': [3446], 'Braunschweig,': [3447], 'Tau': [3449, 3497], 'vitrowas': [3452], 'tau-32': [3460], '(provided': [3461], 'Goedert)': [3465], 'substrate.': [3468], 'concentrations,': [3478], 'assay': [3482], 'conditions': [3483], 'above,': [3485], 'stopped': [3490], 'addition': [3492], 'Laemmli': [3494], 'sample': [3495], 'buffer.': [3496], 'level': [3506], 'autoradiography.': [3510], 'Adult': [3511], 'mouse': [3512], 'brain': [3513], 'striatal': [3514], 'slices': [3515, 3548], 'standard': [3519, 3600], 'methodology': [3520], '(47Nishi': [3521], 'Neurosci.': [3528], '17:': [3530], '8147-8155Crossref': [3531], 'Following': [3535], 'equilibration': [3536], "Krebs'": [3538, 3567], 'bicarbonate': [3539, 3568], 'oxygenated': [3541], 'continuous': [3543], 'aeration': [3544], '(95%': [3545], 'O2/5%': [3546], 'CO2),': [3547], 'concentrations': [3553, 3590, 3763, 3998, 4072, 4149, 4238], 'roscovitine': [3559], 'left': [3565], 'period': [3573], 'time.': [3575], 'Slices': [3576], 'homogenized': [3578], 'sonication': [3580], 'boiling': [3582], 'SDS': [3584], 'NaF.': [3588], 'Protein': [3589], 'BCA': [3595], 'method': [3596], 'BSA': [3599], 'curve.': [3601], 'Equal': [3602], '(80': [3606], 'subjected': [3609], '15%': [3614], 'acrylamide': [3615], 'gel,': [3616], 'electrophoretically': [3617], 'nitrocellulose': [3620], 'immunoblotted': [3623], 'state-specific': [3627], 'selectively': [3630], 'detects': [3631], 'course': [3676], 'studying': [3678], 'indole': [3690, 4000, 4240], 'dimers': [3693], '(TableI).': [3694], 'While': [3695], 'investigating': [3697], 'inhibition': [3700, 3732, 3783], 'indirubin-3′-monoxime,': [3703], 'our': [3708], 'cellular': [3709, 3934, 4203], 'studies,': [3710], 'noticed': [3712], 'inhibitor': [3719, 4171], 'Our': [3724], 'collection': [3725], 'indoles/bis-indoles': [3727], 'evaluated': [3730], 'CDK5/p25,': [3736, 4043, 4118], '(GSK-3β,': [3748], 'GS1': [3749], 'peptide;': [3750], 'H1)': [3753], 'increasing': [3762, 3997, 4071, 4148, 4237], 'compounds.': [3765], 'IC50': [3766, 3820, 3829, 4002, 4075, 4086], 'dose-response': [3772, 3896, 4008, 4094], 'curves': [3773, 3897, 4095, 4166], 'presented': [3776, 3938, 4104, 4154], 'TableII.': [3778], 'limited': [3786], 'family.': [3790], 'Neither': [3791], 'nor': [3793], 'isatin,': [3794], 'derivatives,': [3797], 'displayed': [3798], 'significant': [3800], 'effect': [3801], 'any': [3803], 'three': [3806, 3906], 'compare': [3809], 'enzyme': [3824], 'plotted': [3826, 4083], 'two': [3834, 4091], '(Fig.': [3836], '2).': [3837], 'analysis': [3839], 'efficacies': [3843, 3855], 'CDK1': [3847, 3871], 'closely': [3851], 'related,': [3852], 'whereas': [3853], 'less': [3861], 'so.': [3862], 'probably': [3864], 'reflects': [3865], 'closer': [3867], 'evolutionary': [3868], 'proximity': [3869], 'between': [3870, 3877], '(48Hanks': [3881], 'S.K.': [3882], 'Hunter': [3883], 'FASEB': [3885], '576-596Crossref': [3889], '(2322)': [3892], '(a)': [3899], '(5-iodo-indirubin-3′-monoxime),': [3908], '(b)': [3909], 'GSK-3β-selective': [3912, 4179], '(5,5′-dibromoindirubin),': [3914], '(c)': [3915], 'CDK-selective': [3918, 4186], '(5-sulfonic': [3920, 4188], 'acid-indirubin-3′-monoxime),': [3921], '(d)': [3923], 'frequently': [3926, 4195], "indirubins'": [3933, 4202], '(indirubin-3′-monoxime)': [3936, 4205], '3.Table': [3941], 'IStructure': [3942], 'Open': [3952, 4027], 'table': [3953, 4028], 'new': [3956, 4031], 'tab': [3957, 4032], 'Table': [3958, 3982, 4222], 'IIInhibition': [3959], 'CDK1,': [3962], 'bis-indolesView': [3968], 'Large': [3969, 4107, 4208], 'Image': [3970, 4108, 4209], 'Figure': [3971, 4033, 4109, 4210], 'ViewerDownload': [3972, 4110, 4211], 'Hi-res': [3973, 4111, 4212], 'image': [3974, 4112, 4213], 'Download': [3975, 4113, 4214], '(PPT)Numbers': [3976], 'refer': [3977, 4217], 'structures': [3979, 4219], 'shown': [3980, 4165, 4220], 'I.': [3983, 4223], 'Enzyme': [3984, 4224], '“Experimental': [3991, 4231], 'Procedures,”': [3992, 4232], 'derivatives.': [4001, 4241], 'curves.': [4009], '≤0.01': [4010], '(solid': [4012], 'black),': [4013], '0.01–0.1': [4014], '(dark': [4016], 'gray),': [4017, 4020, 4024], '0.1–1': [4018], 'μm(medium': [4019], '(light': [4023], '>10': [4025], 'μm(white).': [4026], '2Comparisons': [4034], 'substrates,': [4060, 4137], 'respectively,': [4061, 4138], 'indirubins.': [4074, 4123, 4151], 'enzyme,': [4079], 'graphically,': [4081], '14,': [4099], '15,': [4100], '19': [4102], 'Fig.3.View': [4106], '(PPT)Figure': [4114], '3Inhibition': [4115], 'Activity': [4152], '(no': [4161], 'inhibitors).': [4162], 'Dose-response': [4163], '(5-iodo-indirubin-3′-monoxime)': [4174], '(15)': [4175], '(A),': [4176], '(5,5′-dibromoindirubin)': [4181], '(12)': [4182], '(B),': [4183], 'acid-indirubin-3′-monoxime)': [4189], '(19)': [4190], '(C),': [4191], '(14)': [4206], '(D).View': [4207], '(PPT)': [4215], 'Numbers': [4216], 'IC5': [4242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2104373322', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 27}, {'year': 2022, 'cited_by_count': 27}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 27}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 23}, {'year': 2016, 'cited_by_count': 30}, {'year': 2015, 'cited_by_count': 31}, {'year': 2014, 'cited_by_count': 39}, {'year': 2013, 'cited_by_count': 28}, {'year': 2012, 'cited_by_count': 42}], 'updated_date': '2024-12-10T18:33:52.332013', 'created_date': '2016-06-24'}
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