Title: Control of Cell Behavior by Aligned Micro/Nanofibrous Biomaterial Scaffolds Fabricated by Spinneret‐Based Tunable Engineered Parameters (STEP) Technique
Abstract: SmallVolume 4, Issue 8 p. 1153-1159 Communication Control of Cell Behavior by Aligned Micro/Nanofibrous Biomaterial Scaffolds Fabricated by Spinneret-Based Tunable Engineered Parameters (STEP) Technique† Amrinder S. Nain, Corresponding Author Amrinder S. Nain [email protected] Department of Mechanical Engineering and Institute for Complex Engineered Systems (ICES), Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Department of Mechanical Engineering and Institute for Complex Engineered Systems (ICES), Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA). Fax: (+1) 412-268-5229Search for more papers by this authorJulie A. Phillippi, Julie A. Phillippi Molecular Biosensor and Imaging Center (MBIC) and Institute for Complex Engineered Systems (ICES) Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Search for more papers by this authorMetin Sitti, Metin Sitti Department of Mechanical Engineering Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Search for more papers by this authorJames MacKrell, James MacKrell Molecular Biosensor and Imaging Center (MBIC) and Institute for Complex Engineered Systems (ICES) Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Search for more papers by this authorPhil G. Campbell, Phil G. Campbell Molecular Biosensor and Imaging Center (MBIC) and Institute for Complex Engineered Systems (ICES) Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Search for more papers by this authorCristina Amon, Cristina Amon Faculty of Applied Science and Engineering Department of Mechanical and Industrial Engineering University of Toronto, Toronto, ON M5S 1A4 (Canada)Search for more papers by this author Amrinder S. Nain, Corresponding Author Amrinder S. Nain [email protected] Department of Mechanical Engineering and Institute for Complex Engineered Systems (ICES), Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Department of Mechanical Engineering and Institute for Complex Engineered Systems (ICES), Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA). Fax: (+1) 412-268-5229Search for more papers by this authorJulie A. Phillippi, Julie A. Phillippi Molecular Biosensor and Imaging Center (MBIC) and Institute for Complex Engineered Systems (ICES) Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Search for more papers by this authorMetin Sitti, Metin Sitti Department of Mechanical Engineering Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Search for more papers by this authorJames MacKrell, James MacKrell Molecular Biosensor and Imaging Center (MBIC) and Institute for Complex Engineered Systems (ICES) Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Search for more papers by this authorPhil G. Campbell, Phil G. Campbell Molecular Biosensor and Imaging Center (MBIC) and Institute for Complex Engineered Systems (ICES) Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA 15213 (USA)Search for more papers by this authorCristina Amon, Cristina Amon Faculty of Applied Science and Engineering Department of Mechanical and Industrial Engineering University of Toronto, Toronto, ON M5S 1A4 (Canada)Search for more papers by this author First published: 31 July 2008 https://doi.org/10.1002/smll.200800101Citations: 50 † A. S. Nain and J. A. Phillippi contributed equally to this work. The authors gratefully acknowledge Eric Miller, Bahareh Behkam, Franklin Chung, Jason Smith, James Fitzpatrick, Greg Fisher, and Joseph Suhan for scaffold preparation and imaging assistance, Alan Waggoner, director of the Molecular Biosensor and Imaging Center (CMU) for use of the facilities, and Jonathan Jarvik for providing the GFP-α-tubulin vector. The authors are thankful to Purac Biochem, The Netherlands for supplying experimental polymeric samples. This work was supported in part by the Pennsylvania Infrastructure Technology Alliance (PITA: ASN, PGC, and MS), the Pittsburgh Tissue Engineering Initiative (JAP), and the NSF CAREER program (MS, NSF IIS-0448042). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract STEP by STEP: A method for depositing customized single and multilayer biomaterial scaffolds (see image) using point-to-point and continuous techniques is described. Proliferation and migration of mouse C2C12 progenitor cells occurs along the fiber axis on single-layered scaffolds and on double-layered orthogonal scaffolds spreading along the two layers, and right-angle transitions can be seen. Citing Literature Volume4, Issue8August 2008Pages 1153-1159 RelatedInformation
Publication Year: 2008
Publication Date: 2008-07-31
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 71
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