Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2103711607', 'doi': 'https://doi.org/10.1001/archophthalmol.2009.265', 'title': 'Preclinical Evaluation of the Novel Small-Molecule Integrin α5β1 Inhibitor JSM6427 in Monkey and Rabbit Models of Choroidal Neovascularization', 'display_name': 'Preclinical Evaluation of the Novel Small-Molecule Integrin α5β1 Inhibitor JSM6427 in Monkey and Rabbit Models of Choroidal Neovascularization', 'publication_year': 2009, 'publication_date': '2009-10-12', 'ids': {'openalex': 'https://openalex.org/W2103711607', 'doi': 'https://doi.org/10.1001/archophthalmol.2009.265', 'mag': '2103711607', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19822850'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/archophthalmol.2009.265', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80523760', 'display_name': 'Archives of Ophthalmology', 'issn_l': '0003-9950', 'issn': ['0003-9950', '1538-3601'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5017359762', 'display_name': 'Grit Zahn', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Grit Zahn', 'raw_affiliation_strings': ['Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5017359762'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.736, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 59, 'citation_normalized_percentile': {'value': 0.924891, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '127', 'issue': '10', 'first_page': '1329', 'last_page': '1329'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10881', 'display_name': 'Blood Coagulation and Thrombosis Mechanisms', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10250', 'display_name': 'Glaucoma and retinal disorders', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rabbit', 'display_name': 'Rabbit (cipher)', 'score': 0.658448}], 'concepts': [{'id': 'https://openalex.org/C2781359195', 'wikidata': 'https://www.wikidata.org/wiki/Q5105209', 'display_name': 'Choroidal neovascularization', 'level': 3, 'score': 0.7206483}, {'id': 'https://openalex.org/C2779884254', 'wikidata': 'https://www.wikidata.org/wiki/Q492162', 'display_name': 'Rabbit (cipher)', 'level': 2, 'score': 0.658448}, {'id': 'https://openalex.org/C195687474', 'wikidata': 'https://www.wikidata.org/wiki/Q409715', 'display_name': 'Integrin', 'level': 3, 'score': 0.60308176}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.57922655}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.407685}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3207484}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.293939}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.24998975}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.23838165}, {'id': 'https://openalex.org/C2776403814', 'wikidata': 'https://www.wikidata.org/wiki/Q27429789', 'display_name': 'Macular degeneration', 'level': 2, 'score': 0.22675738}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.17542368}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.14193124}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12024629}, {'id': 'https://openalex.org/C38652104', 'wikidata': 'https://www.wikidata.org/wiki/Q3510521', 'display_name': 'Computer security', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000631', 'descriptor_name': 'Aminopyridines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D020256', 'descriptor_name': 'Choroidal Neovascularization', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D039081', 'descriptor_name': 'Integrin alpha5beta1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D015091', 'descriptor_name': 'beta-Alanine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000631', 'descriptor_name': 'Aminopyridines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000631', 'descriptor_name': 'Aminopyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020256', 'descriptor_name': 'Choroidal Neovascularization', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D020256', 'descriptor_name': 'Choroidal Neovascularization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004596', 'descriptor_name': 'Electroretinography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016222', 'descriptor_name': 'Fibroblast Growth Factor 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016222', 'descriptor_name': 'Fibroblast Growth Factor 2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D005451', 'descriptor_name': 'Fluorescein Angiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007267', 'descriptor_name': 'Injections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039081', 'descriptor_name': 'Integrin alpha5beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008252', 'descriptor_name': 'Macaca fascicularis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014822', 'descriptor_name': 'Vitreous Body', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015091', 'descriptor_name': 'beta-Alanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015091', 'descriptor_name': 'beta-Alanine', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D015091', 'descriptor_name': 'beta-Alanine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/archophthalmol.2009.265', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80523760', 'display_name': 'Archives of Ophthalmology', 'issn_l': '0003-9950', 'issn': ['0003-9950', '1538-3601'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19822850', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.74, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1006892264', 'https://openalex.org/W1127991487', 'https://openalex.org/W1180857912', 'https://openalex.org/W1479820498', 'https://openalex.org/W1491981736', 'https://openalex.org/W1576773659', 'https://openalex.org/W1582963778', 'https://openalex.org/W182527921', 'https://openalex.org/W1905978178', 'https://openalex.org/W1966752271', 'https://openalex.org/W1971019443', 'https://openalex.org/W1986424967', 'https://openalex.org/W2011638075', 'https://openalex.org/W2016584341', 'https://openalex.org/W2021888919', 'https://openalex.org/W2022415270', 'https://openalex.org/W2026167503', 'https://openalex.org/W2028267966', 'https://openalex.org/W2031540625', 'https://openalex.org/W2044759195', 'https://openalex.org/W2050014442', 'https://openalex.org/W2053837765', 'https://openalex.org/W2055235355', 'https://openalex.org/W2057046543', 'https://openalex.org/W2058635875', 'https://openalex.org/W2064839214', 'https://openalex.org/W2070134611', 'https://openalex.org/W2071958672', 'https://openalex.org/W2075018860', 'https://openalex.org/W2076548316', 'https://openalex.org/W2077090481', 'https://openalex.org/W2118551928', 'https://openalex.org/W2122761637', 'https://openalex.org/W2127112848', 'https://openalex.org/W2160144595', 'https://openalex.org/W2165142876', 'https://openalex.org/W2166984623', 'https://openalex.org/W2169906117', 'https://openalex.org/W2171118123', 'https://openalex.org/W2186885893', 'https://openalex.org/W2188422153', 'https://openalex.org/W2322318138', 'https://openalex.org/W2327877667', 'https://openalex.org/W2397477141', 'https://openalex.org/W2398248435'], 'related_works': ['https://openalex.org/W88626775', 'https://openalex.org/W4387408042', 'https://openalex.org/W4299437800', 'https://openalex.org/W4238609873', 'https://openalex.org/W3185440465', 'https://openalex.org/W3027684582', 'https://openalex.org/W2504722549', 'https://openalex.org/W2415429099', 'https://openalex.org/W2401078342', 'https://openalex.org/W2076711558'], 'abstract_inverted_index': {'<h3>Objective</h3>': [0], 'To': [1], 'evaluate': [2], 'the': [3, 42, 77, 123, 156, 188], 'pharmacologic': [4], 'activity': [5], 'and': [6, 12, 22, 56, 81, 98, 112, 142, 175], 'tolerability': [7, 94], 'of': [8, 17, 25, 44, 64, 114, 129, 138, 162, 171, 190], 'JSM6427,': [9], 'a': [10, 52, 57, 133, 184], 'potent': [11], 'first': [13], 'selective': [14, 121], 'small-molecule': [15], 'inhibitor': [16], 'integrin': [18], 'α5β1,': [19], 'in': [20, 37, 51, 100, 105, 132, 140, 173, 199], 'monkey': [21, 54, 174], 'rabbit': [23, 60, 176], 'models': [24, 145], 'choroidal': [26], 'neovascularization': [27], '(CNV).': [28], '<h3>Methods</h3>': [29], 'JSM6427': [30, 45, 65, 115, 118, 130, 152, 167, 181], 'selectivity': [31], 'for': [32, 85, 122, 187], 'α5β1': [33], 'was': [34, 49, 90, 95, 119, 153], 'evaluated': [35, 96], 'by': [36], 'vitro': [38], 'binding': [39], 'assays': [40], 'while': [41], 'ability': [43], 'to': [46], 'inhibit': [47], 'CNV': [48, 78, 139, 172], 'investigated': [50], 'laser-induced': [53, 141], 'model': [55], 'growth': [58, 143], 'factor–induced': [59, 144], 'model.': [61], 'Intravitreal': [62, 166], 'injections': [63, 128], '(100,': [66], '300,': [67], 'or': [68, 71], '1000': [69], 'μg)': [70], 'vehicle': [72], 'were': [73], 'administered': [74], 'immediately': [75], 'after': [76], 'induction': [79], 'procedure': [80], 'at': [82], 'weekly': [83], 'intervals': [84], '4': [86], 'weeks.': [87], 'Fluorescein': [88], 'angiography': [89], 'performed': [91], 'weekly.': [92], 'Ocular': [93], 'ophthalmoscopically': [97], 'histologically': [99], 'both': [101], 'models;': [102], 'additional': [103], 'assessments': [104], 'monkeys': [106], 'included': [107], 'electroretinography,': [108], 'biomicroscopy,': [109], 'pathological': [110], 'examination,': [111], 'analysis': [113], 'pharmacokinetics.': [116], '<h3>Results</h3>': [117], 'highly': [120], 'α5β1-fibronectin': [124], 'interaction.': [125], 'Weekly': [126], 'intravitreal': [127], 'resulted': [131], 'statistically': [134], 'significant': [135], 'dose-dependent': [136, 169], 'inhibition': [137, 170], 'without': [146], 'any': [147], 'ocular': [148, 191], 'JSM6427-related': [149], 'adverse': [150], 'effects.': [151], 'cleared': [154], 'through': [155], 'systemic': [157, 163], 'circulation': [158], 'with': [159], 'no': [160], 'evidence': [161], 'accumulation.': [164], '<h3>Conclusions</h3>': [165], 'provided': [168], 'experimental': [177], 'models.': [178], '<h3>Clinical': [179], 'Relevance</h3>': [180], 'may': [182], 'provide': [183], 'new': [185], 'approach': [186], 'treatment': [189], 'neovascular': [192], 'diseases': [193], 'such': [194], 'as': [195], 'age-related': [196], 'macular': [197], 'degeneration': [198], 'humans.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2103711607', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-29T23:09:46.479738', 'created_date': '2016-06-24'}