Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2103569939', 'doi': 'https://doi.org/10.2174/18715206113136660334', 'title': 'Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines', 'display_name': 'Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines', 'publication_year': 2014, 'publication_date': '2014-06-16', 'ids': {'openalex': 'https://openalex.org/W2103569939', 'doi': 'https://doi.org/10.2174/18715206113136660334', 'mag': '2103569939', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24066799', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4104455'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/18715206113136660334', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159246083', 'display_name': 'Anti-Cancer Agents in Medicinal Chemistry', 'issn_l': '1871-5206', 'issn': ['1871-5206', '1875-5992'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc4104455?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5105472068', 'display_name': 'Georgina Alexandra Cardama', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Georgina Alexandra Cardama', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068605061', 'display_name': 'María J. Comin', 'orcid': 'https://orcid.org/0000-0003-2187-1932'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Maria Julieta Comin', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029118805', 'display_name': 'Leandro Hornos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210162499', 'display_name': 'Bentham Science Publishers (China)', 'ror': 'https://ror.org/02he3zy15', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210162499']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Leandro Hornos', 'raw_affiliation_strings': ['Bentham Science Publishers'], 'affiliations': [{'raw_affiliation_string': 'Bentham Science Publishers', 'institution_ids': ['https://openalex.org/I4210162499']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047542889', 'display_name': 'Nazareno González', 'orcid': 'https://orcid.org/0000-0003-4013-3396'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nazareno González', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081101274', 'display_name': 'Lucas A. Defelipe', 'orcid': 'https://orcid.org/0000-0001-7859-7300'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lucas Alfredo Defelipe', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035789659', 'display_name': 'Adrián G. Turjanski', 'orcid': 'https://orcid.org/0000-0003-2190-137X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Adrian Turjanski', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053775464', 'display_name': 'Daniel F. Alonso', 'orcid': 'https://orcid.org/0000-0002-0601-613X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Daniel Fernando Alonso', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012774649', 'display_name': 'Daniel E. Gómez', 'orcid': 'https://orcid.org/0000-0002-8629-0787'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Daniel Eduardo Gomez', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012774649', 'display_name': 'Daniel E. Gómez', 'orcid': 'https://orcid.org/0000-0002-8629-0787'}, 'institutions': [{'id': 'https://openalex.org/I138504249', 'display_name': 'National University of Quilmes', 'ror': 'https://ror.org/01r53hz59', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I138504249']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Pablo Lorenzano Menna', 'raw_affiliation_strings': ['Laboratorio de Oncología Molecular, Universidad Nacional de Quilmes. Roque Saenz Pena 352, Bernal B1876BXD Buenos Aires, Argentina.'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Oncología Molecular, Universidad Nacional de Quilmes. Roque Saenz Pena 352, Bernal B1876BXD Buenos Aires, Argentina.', 'institution_ids': ['https://openalex.org/I138504249']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.019, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 75, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '14', 'issue': '6', 'first_page': '840', 'last_page': '851'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ras-signaling', 'display_name': 'Ras Signaling', 'score': 0.480966}], 'concepts': [{'id': 'https://openalex.org/C2779717556', 'wikidata': 'https://www.wikidata.org/wiki/Q15325735', 'display_name': 'RAC1', 'level': 3, 'score': 0.7619966}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.5951282}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.41931888}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.41886428}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3720916}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.37129915}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.35677359}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33176345}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.24687362}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20452866}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006146', 'descriptor_name': 'Guanidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D020830', 'descriptor_name': 'rac1 GTP-Binding Protein', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006146', 'descriptor_name': 'Guanidines', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D006146', 'descriptor_name': 'Guanidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006146', 'descriptor_name': 'Guanidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020830', 'descriptor_name': 'rac1 GTP-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020830', 'descriptor_name': 'rac1 GTP-Binding Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/18715206113136660334', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159246083', 'display_name': 'Anti-Cancer Agents in Medicinal Chemistry', 'issn_l': '1871-5206', 'issn': ['1871-5206', '1875-5992'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4104455', 'pdf_url': 'https://europepmc.org/articles/pmc4104455?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11336/77984', 'pdf_url': 'https://ri.conicet.gov.ar/bitstream/11336/77984/2/CONICET_Digital_Nro.1e397f22-4fd8-4225-bc6e-4ae712d827b0_A.pdf', 'source': {'id': 'https://openalex.org/S4306402455', 'display_name': 'CONICET Digital (CONICET)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210148385', 'host_organization_name': 'Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I4210148385'], 'host_organization_lineage_names': ['Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104455', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24066799', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4104455', 'pdf_url': 'https://europepmc.org/articles/pmc4104455?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W131395037', 'https://openalex.org/W1500337621', 'https://openalex.org/W1532439114', 'https://openalex.org/W1869465538', 'https://openalex.org/W1910650341', 'https://openalex.org/W1914280947', 'https://openalex.org/W1968044382', 'https://openalex.org/W1977461892', 'https://openalex.org/W1982283178', 'https://openalex.org/W1989220634', 'https://openalex.org/W1992583240', 'https://openalex.org/W1992773450', 'https://openalex.org/W1996107157', 'https://openalex.org/W1998329681', 'https://openalex.org/W2004220006', 'https://openalex.org/W2004732764', 'https://openalex.org/W2007727729', 'https://openalex.org/W2010779754', 'https://openalex.org/W2012843157', 'https://openalex.org/W2018631917', 'https://openalex.org/W2019731805', 'https://openalex.org/W2020084080', 'https://openalex.org/W2021005971', 'https://openalex.org/W2021437057', 'https://openalex.org/W2027482274', 'https://openalex.org/W2031951506', 'https://openalex.org/W2035000040', 'https://openalex.org/W2037670359', 'https://openalex.org/W2041580023', 'https://openalex.org/W2042264070', 'https://openalex.org/W2042517746', 'https://openalex.org/W2052795297', 'https://openalex.org/W2068490038', 'https://openalex.org/W2070387453', 'https://openalex.org/W2071018921', 'https://openalex.org/W2071551353', 'https://openalex.org/W2074075635', 'https://openalex.org/W2074403146', 'https://openalex.org/W2074978477', 'https://openalex.org/W2079712059', 'https://openalex.org/W2083451010', 'https://openalex.org/W2087973518', 'https://openalex.org/W2093334583', 'https://openalex.org/W2094680426', 'https://openalex.org/W2095152052', 'https://openalex.org/W2096791952', 'https://openalex.org/W2100356751', 'https://openalex.org/W2100388022', 'https://openalex.org/W2105746559', 'https://openalex.org/W2119875542', 'https://openalex.org/W2124054733', 'https://openalex.org/W2126459224', 'https://openalex.org/W2133613600', 'https://openalex.org/W2134471382', 'https://openalex.org/W2135486627', 'https://openalex.org/W2135768629', 'https://openalex.org/W2136628679', 'https://openalex.org/W2140841583', 'https://openalex.org/W2142685635', 'https://openalex.org/W2144741986', 'https://openalex.org/W2146055738', 'https://openalex.org/W2146473598', 'https://openalex.org/W2153637044', 'https://openalex.org/W2170158378', 'https://openalex.org/W2176516200', 'https://openalex.org/W25707239', 'https://openalex.org/W58899900', 'https://openalex.org/W75937737'], 'related_works': ['https://openalex.org/W4390984186', 'https://openalex.org/W3208887797', 'https://openalex.org/W3204477002', 'https://openalex.org/W2377311222', 'https://openalex.org/W2375584271', 'https://openalex.org/W2370087273', 'https://openalex.org/W2103569939', 'https://openalex.org/W2034971176', 'https://openalex.org/W1997105855', 'https://openalex.org/W1996953995'], 'abstract_inverted_index': {'Rho': [0, 30], 'GTPases': [1], 'play': [2], 'a': [3, 27, 60, 80, 132, 190], 'key': [4], 'role': [5], 'in': [6, 50, 116, 127, 131, 158, 169], 'the': [7, 66, 74, 139, 155], 'regulation': [8], 'of': [9, 25, 29, 32, 68, 172], 'multiple': [10], 'essential': [11], 'cellular': [12], 'processes,': [13], 'including': [14], 'actin': [15], 'dynamics,': [16], 'gene': [17], 'transcription': [18], 'and': [19, 42, 48, 62, 106, 112, 146, 151, 160], 'cell': [20, 108, 110, 113, 121], 'cycle': [21, 114], 'progression.': [22], 'Aberrant': [23], 'activation': [24, 87, 105], 'Rac1,': [26], 'member': [28], 'family': [31], 'small': [33], 'GTPases,': [34], 'is': [35, 46], 'associated': [36], 'with': [37, 98], 'tumorigenesis,': [38], 'cancer': [39, 120], 'progression,': [40], 'invasion': [41], 'metastasis.': [43], 'Particularly,': [44], 'Rac1': [45, 56, 76, 86, 96, 104, 183, 198], 'overexpressed': [47], 'hyperactivated': [49], 'highly': [51, 117], 'aggressive': [52, 118], 'breast': [53, 119], 'cancer.': [54], 'Thus,': [55], 'appears': [57], 'to': [58, 94, 148], 'be': [59, 149, 187], 'promising': [61], 'relevant': [63], 'target': [64], 'for': [65], 'development': [67], 'novel': [69, 75, 140, 182, 191], 'anticancer': [70, 192], 'drugs.': [71], 'We': [72, 136, 164], 'identified': [73], 'inhibitor': [77], 'ZINC69391': [78, 124], 'through': [79], 'docking-based': [81], 'virtual': [82, 202], 'library': [83], 'screening': [84], 'targeting': [85], 'by': [88, 143], 'GEFs.': [89], 'This': [90], 'compound': [91, 157], 'was': [92], 'able': [93], 'block': [95], 'interaction': [97], 'its': [99], 'GEF': [100], 'Tiam1,': [101], 'prevented': [102], 'EGF-induced': [103], 'inhibited': [107], 'proliferation,': [109], 'migration': [111], 'progression': [115], 'lines.': [122], 'Moreover,': [123], 'showed': [125, 147, 166], 'an': [126, 167], 'vivo': [128, 170], 'antimetastatic': [129], 'effect': [130], 'syngeneic': [133], 'animal': [134], 'model.': [135], 'further': [137], 'developed': [138, 181], 'analog': [141], '1A-116': [142, 173], 'rational': [144, 200], 'design': [145], 'specific': [150], 'more': [152], 'potent': [153], 'than': [154], 'parental': [156], 'vitro': [159], 'interfered': [161], 'Rac1-P-Rex1': [162], 'interaction.': [163], 'also': [165], 'enhanced': [168], 'potency': [171], 'analog.': [174], 'These': [175], 'results': [176], 'show': [177], 'that': [178, 185], 'we': [179], 'have': [180], 'inhibitors': [184], 'may': [186], 'used': [188], 'as': [189], 'therapy.': [193], 'Keywords:': [194], 'Breast': [195], 'cancer,': [196], 'docking,': [197], 'inhibitor,': [199], 'design,': [201], 'screening.': [203]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2103569939', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2024-09-13T10:32:27.397708', 'created_date': '2016-06-24'}