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358, 419, 478, 556, 757, 923, 1111, 1140], 'favoritesTrack': [314], 'citation': [315], 'ShareShare': [316], 'Give': [317], 'accessShare': [318, 321], 'text': [320], 'full-text': [322, 337, 361], 'accessPlease': [323], 'review': [324], 'our': [325], 'Terms': [326, 349], 'Conditions': [328, 351], 'Use': [330], 'check': [332], 'box': [333], 'below': [334, 357], 'share': [336, 359], 'version': [338, 362], 'article.I': [340], 'have': [341], 'read': [342], 'accept': [344], 'Wiley': [346, 583], 'Online': [347], 'Library': [348], 'UseShareable': [353], 'LinkUse': [354], 'link': [356], 'a': [360, 375, 857, 1031, 1141], 'article': [365], 'with': [366, 412, 475, 515, 630, 751, 912], 'your': [367], 'friends': [368], 'colleagues.': [370], 'Learn': [371], 'more.Copy': [372], 'URL': [373], 'Share': [374], 'linkShare': [376], 'onEmailFacebookTwitterLinkedInRedditWechat': [377], 'Abstract': [378], 'The': [379, 452, 484, 500, 526, 562, 915, 1652], 'effects': [380, 776, 1004, 1056, 1353, 1490], 'hesperetin': [382, 413, 476, 518, 535, 548, 1165, 1242, 1357, 1655], 'on': [383, 433, 443, 877, 1358, 1402, 1437], 'pharmacokinetics': [385, 552, 1404, 1439], 'role': [388, 501], '(P-gp)': [391], 'transport': [394], 'felodipine': [396, 467, 514, 541, 554, 631, 876, 1133], 'were': [397, 427, 468], 'investigated': [398], 'rats': [400, 420, 1443, 1538], 'vitro.': [403], 'was': [405, 491], 'administered': [406], 'orally': [407], '(10': [408], 'mg/kg)': [409, 418], 'without': [410, 517], 'or': [411, 516], '(25,': [414], '50': [415], '100': [417, 917], '15': [422], 'consecutive': [423], 'days.': [424], 'Blood': [425], 'samples': [426], 'collected': [428], 'at': [429], 'different': [430], 'time': [431, 490], 'intervals': [432], '1st': [434], 'day': [435, 445], 'single': [437, 1169], 'dose': [438, 448, 598], 'pharmacokinetic': [439, 449, 1142], 'study': [440, 450, 1143, 1532], '(SDS)': [441], '15th': [444], 'multiple': [447, 1489], '(MDS).': [451], 'area': [453], 'under': [454], 'plasma': [456, 463], 'concentration–time': [457], 'curve': [458], '(AUC0–∞)': [459], 'peak': [462], 'concentration': [464], '(Cmax)': [465], 'dose-dependently': [469], 'increased': [470, 536], 'SDS': [472], 'MDS': [474], 'compared': [477], 'control': [479, 495], '(': [480], 'p': [481], '<': [482, 543], '0.001).': [483], 'half-life': [485], '(t1/2)': [486], 'mean': [488], 'residence': [489], 'longer': [492], 'than': [493], 'group': [496], 'both': [498], 'studies.': [499, 675], 'P-gp': [503, 522, 572, 1324], 'determined': [504], 'using': [505, 728], 'everted': [506, 1330], 'rat': [507, 609, 692, 1137], 'gut': [508, 1331], 'sacs': [509], 'vitro': [511, 528, 730, 1328, 1446, 1541, 1687], 'incubating': [513], 'verapamil': [520, 533], '(typical': [521], 'CYP3A4': [524], 'inhibitor).': [525], 'experiments': [529], 'revealed': [530], 'that': [531], 'intestinal': [538, 725, 1319, 1338], 'absorption': [539, 670, 726, 1320], '(p': [542], '0.01).': [544], 'Concurrent': [545], 'use': [546], 'dramatically': [549], 'altered': [550], 'leading': [555], 'an': [557], 'increase': [558], 'systemic': [560], 'exposure.': [561], 'likely': [563], 'mechanism': [564, 884], 'is': [565], 'inhibition': [566, 1081], 'CYP3A4-mediated': [568], 'first-pass': [569], 'metabolism': [570, 1267], 'intestine': [575], 'liver.': [578], 'Copyright': [579], '©': [580], 'John': [582], '&': [584], 'Sons,': [585], 'Ltd.': [586], 'REFERENCES': [587], 'Aranganathan': [588], 'S,': [589, 796, 838, 1182, 1279, 1648], 'Panneer': [590], 'Selvam': [591], 'J,': [592, 665, 706], 'Nalini': [593], 'N.': [594], '2008.': [595, 896, 1351], 'exerts': [597], 'dependent': [599], 'chemopreventive': [600], 'effect': [601], 'against': [602], '1,': [603], '2': [604], '-': [605, 920], 'dimethyl': [606], 'hydrazine': [607], 'induced': [608, 1028], 'colon': [610, 1475], 'carcinogenesis.': [611], 'Invest': [612], 'New': [613], 'Drugs': [614, 888], '27:': [615], '203–213.': [616], 'Bailey': [617], 'DG,': [618], 'Spence': [619], 'JD,': [620, 1374], 'Munoz': [621], 'C,': [622, 712, 1204], 'Arnold': [623], 'JM.': [624], '1991.': [625, 1507], 'Interaction': [626], 'citrus': [628, 1162, 1653], 'juices': [629], 'nifedipine.': [633], 'Lancet': [634, 974], '337:': [635], '268–269.': [636], 'Bansal': [637], 'T,': [638], 'Jaggi': [639], 'M,': [640, 789, 792, 1122, 1155, 1309, 1626], 'Khar': [641], 'RK,': [642], 'Talegaonkar': [643], 'S.': [644, 770], '2009.': [645, 841, 1484], 'Emerging': [646], 'Significance': [647], 'Flavonoids': [649, 1485], 'as': [650, 856, 1297], 'P-Glycoprotein': [651, 1215], 'Inhibitors': [652], 'Cancer': [654], 'Chemotherapy.': [655], 'J': [656, 762, 780, 951, 1176, 1223, 1303, 1341, 1365, 1389, 1415, 1666, 1692], 'Pharm': [657, 763, 1342, 1416, 1451, 1546], 'Pharmaceut': [658], 'Sci': [659, 764, 1417, 1620], '12:': [660], '46–78.': [661], 'Barthe': [662], 'L,': [663, 934, 1311, 1346, 1644], 'Woodley': [664], 'Houin': [666], 'G.': [667], '1999.': [668, 1002, 1104], 'Gastrointestinal': [669], 'drugs:': [672], 'methods': [673], 'Fundam': [676], 'Clin': [677, 860, 952, 1177, 1224, 1248, 1390], 'Pharmacol': [678, 830, 861, 953, 1225, 1273, 1391, 1479, 1693], '13:': [679, 1601], '154–168.': [680], 'Benet': [681, 1575], 'LZ,': [682], 'Wu': [683, 1573], 'C-Y.': [684], '2003.': [685, 1075, 1238, 1629], 'Disposition': [686], 'tacrolimus': [688], 'isolated': [690], 'perfused': [691], 'liver:': [693], 'Influence': [694, 1399, 1434], 'troleandomycin,': [696], 'cyclosporine,': [697], 'GG918.': [699], 'Metab': [701], 'Dispos': [702], '31:': [703, 1013], '1292–1295.': [704], 'Capraro': [705], 'Clemente': [707], 'A,': [708, 714, 740, 868, 1095, 1202, 1672], 'Rubio': [709], 'LA,': [710], 'Magni': [711], 'Scarafoni': [713], 'Duranti': [715], '2011.': [717, 1316, 1398], 'Assessment': [718], 'lupin': [721], 'seed': [722], 'glucose-lowering': [723], 'protein': [724], 'ex': [732], 'vivo': [733, 759], 'models.': [734, 1447, 1542], 'Food': [735, 808, 1035, 1367], 'Chem': [736, 1036, 1305, 1368], '125:': [737], '1279–1283.': [738], 'Collett': [739], 'Tanianis-Hughes': [741], 'J.': [742, 1397], '2005.': [743, 799, 819, 1207], 'Comparison': [744], 'P-glycoprotein-mediated': [746], 'drug-digoxin': [747], 'interactions': [748, 823, 946, 1633], 'Caco-2': [750], 'human': [752, 1173, 1474], 'rodent': [754], 'intestine:': [755], 'relevance': [756], 'prediction.': [760], 'Eur': [761, 1175, 1388, 1414, 1691], '26:': [765, 1641], '386–93.': [766], 'Cook': [767], 'NC,': [768], 'Samman': [769], '1996.': [771, 873, 1377, 1460], 'Flavonoids-chemistry,': [772], 'metabolism,': [773], 'cardio': [774], 'protective': [775], 'dietary': [778, 1008], 'sources.': [779], 'Nutr': [781, 1178, 1496, 1667], 'Biochem': [782, 1272, 1668], '7:': [783], '66–76.': [784], 'Di': [785], 'Majo': [786], 'D,': [787], 'Giammanco': [788, 795], 'La': [790], 'Guardia': [791], 'Tripoli': [793], 'E,': [794], 'Finotti': [797], 'E.': [798], 'Flavanones': [800], 'Citrus': [802, 1032], 'fruit:': [803], 'Structure': [804], 'antioxidant': [805, 966], 'activity': [806, 1595], 'relationships.': [807], 'Res': [809, 1012, 1068, 1516, 1568], 'Int': [810, 1340], '38:': [811], '1161–1166.': [812], 'Fang': [813], 'S-H,': [814], 'Hou': [815, 1611], 'Y-C,': [816, 1017], 'Chao': [817, 1605], 'P-DL.': [818], 'Pharmacokinetic': [820, 1378, 1530, 1552], 'pharmacodynamic': [822], 'morin': [825], 'cyclosporine.': [827], 'Toxicol': [828, 1037], 'Appl': [829], '205:': [831], '65–70.': [832], 'Fenner': [833], 'KS,': [834], 'Troutman': [835], 'MD,': [836], 'Kempshall': [837], 'et': [839, 871, 1314], 'al.': [840, 872, 1315], 'Drug–Drug': [842], 'Interactions': [843, 919], 'Mediated': [844], 'Through': [845], 'P-Glycoprotein:': [846], 'Clinical': [847], 'Relevance': [848], 'In': [850, 914], 'Vitro–': [851], 'InVivo': [852], 'Correlation': [853], 'Digoxin': [855], 'Probe': [858], 'Drug.': [859], 'Ther': [862, 889, 1567], '85:': [863], '173–181.': [864], 'Ferrari': [865], 'R,': [866, 1254, 1674], 'Cargnoni': [867], 'Bernocchi': [869], 'P,': [870, 1395, 1421], 'Effects': [874], 'ischemic': [879, 1114], 'heart:': [880], 'Insight': [881], 'into': [882], 'cytoprotection.': [886], 'Cardiovasc': [887], '10:': [890], '425–437.': [891], 'Hansten': [892], 'PD,': [893, 1606], 'Horn': [894], 'JR.': [895], 'P450': [898, 906, 1586], 'Enzymes': [899], 'Interactions,': [902], 'Table': [903], 'Substrates,': [907], 'Inhibitors,': [908], 'Inducers': [909], 'P-glycoprotein,': [911], 'Footnotes.': [913], 'Top': [916], 'A': [921, 1562], 'guide': [922], 'Patient': [924], 'Management,': [925], '2008': [926], 'Edition.': [927], 'Freeland,': [928], 'WA:': [929], 'H&H': [930], 'Publications,': [931], '142–157.': [932], 'Henderson': [933], 'Yue': [935], 'QY,': [936], 'Bergquist': [937], 'C.': [938, 1528], '2002.': [939], 'St': [940], "John's": [941], 'wort': [942], '(Hypericum': [943], 'perforatum):': [944], 'drug': [945, 1592, 1632], 'clinical': [948], 'outcomes.': [949], 'Br': [950], '54:': [954], '349–356.': [955], 'Hertog': [956], 'MG,': [957], 'Hollman': [958, 998], 'PCH,': [959], 'Katan': [960, 1000], 'MB,': [961], 'Kromhout': [962], 'D.': [963], '1993.': [964], 'Dietary': [965], 'flavonoids': [967], 'risk': [969, 1112], 'coronary': [971], 'heart': [972], 'disease.': [973], '342:': [975], '1007–1011.': [976], 'Hishikawa': [977], 'K,': [978, 1424, 1429], 'Lüscher': [979], 'TF.': [980], '1998.': [981, 1286], 'Inhibits': [983], 'Free-Radical': [984], 'Production': [985], 'Cytokines': [987], 'Glucose': [989], 'Human': [991], 'Smooth': [992], 'Muscle': [993], 'Cells.': [994], 'Hypertension': [995], '32:': [996], '1011–1015.': [997], 'PC,': [999], 'MB.': [1001], 'Health': [1003], 'bioavailability': [1006], 'flavonols.': [1009], 'Free': [1010], 'Radicals': [1011], 'S75–S80': [1014], '(Suppl).': [1015], 'Huang': [1016], 'Liu': [1018, 1345], 'K-C,': [1019], 'Chiou': [1020], 'Y-L.': [1021], '2012.': [1022, 1651], 'Melanogenesis': [1023], 'murine': [1025], 'melanoma': [1026], 'cells': [1027], 'hesperetin,': [1030], 'hydrolysate-derived': [1033], 'falconoid.': [1034], '50:': [1038, 1392], '653–659.': [1039], 'Jeon': [1040], 'SM,': [1041], 'Kim': [1042, 1044, 1228], 'HK,': [1043, 1229], 'HJ,': [1045], 'Do': [1046], 'GM,': [1047], 'Jeong': [1048, 1230], 'TS,': [1049], 'Park': [1050, 1234], 'YB.': [1051], '2007.': [1052, 1158], 'Hypocholesterolemic': [1053], 'antioxidative': [1055], 'naringenin': [1058, 1167, 1355], 'its': [1060], 'two': [1061], 'metabolites': [1062, 1243], 'high-cholesterol': [1064, 1245], 'fed': [1065, 1246], 'rats.': [1066, 1145, 1247, 1413], 'Transl': [1067], '149:': [1069], '15–21.': [1070], 'Jiunn': [1071], 'H,': [1072, 1313], 'Lin': [1073], 'JH.': [1074], 'D': [1076], 'rug–drug': [1077], 'interaction': [1078, 1379, 1531, 1553, 1616], 'mediated': [1079], 'induction': [1083], 'P-glycoprotein.': [1085], 'Adv': [1086], 'Deliv': [1088], 'Rev': [1089], '55:': [1090], '53–81.': [1091], 'Joshipura': [1092], 'KJ,': [1093], 'Ascherio': [1094], 'Manson': [1096], 'JE,': [1097], 'Stampfer': [1098], 'MJ,': [1099], 'Rimm': [1100], 'EB,': [1101], 'Speizer': [1102], 'FE.': [1103], 'Fruit': [1105], 'vegetable': [1107], 'intake': [1108], 'relation': [1110], 'stroke.': [1115], 'JAMA': [1116], '282:': [1117], '1233–1239.': [1118], 'Kallem': [1119], 'RR,': [1120], 'Ramesh': [1121], 'Seshagirirao': [1123], 'JVLN.': [1124], '2013.': [1125, 1433, 1529], 'Validated': [1126], 'LC-ESI-MS/MS': [1127], 'method': [1128], 'simultaneous': [1130], 'quantitation': [1131], 'metoprolol': [1135], 'plasma:': [1138], 'application': [1139], 'Biomed': [1146], 'Chromatogr': [1147], 'DOI:': [1148], '10.1002/bmc.2861': [1149], 'Kanaze': [1150], 'FI,': [1151], 'Bounartzi': [1152], 'MI,': [1153], 'Georgarakis': [1154], 'Niopas': [1156], 'I.': [1157], 'Pharmacokinetics': [1159], 'flavanone': [1163], 'aglycones': [1164], 'after': [1168], 'oral': [1170], 'administration': [1171], 'subjects.': [1174], '61:': [1179], '472–477.': [1180], 'Kazda': [1181], 'Knorr': [1183], 'A.': [1184], '1990.': [1185], 'Handbook': [1186], 'Experimental': [1188], 'Pharmacology,': [1189], 'Pharmacology': [1190], 'Antihypertensive': [1192], 'Therapeutics,': [1193], 'vol.': [1194], '93.': [1195], 'Berlin:': [1196], 'Springer-Verlag,': [1197], '301.': [1198], 'Kharasch': [1199], 'ED,': [1200], 'Walker': [1201], 'Hoffer': [1203], 'Sheffels': [1205], 'Alfentanil': [1218], 'Fexofenadine': [1220], 'Combination.': [1222], '45:': [1226], '79–88.': [1227], 'T-S,': [1231], 'Lee': [1232], 'M-K,': [1233], 'YB,': [1235], 'Choi': [1236], 'M-S.': [1237], 'Lipid-lowering': [1239], 'efficacy': [1240], 'Chim': [1249], 'Acta': [1250], '327:': [1251], '129–137.': [1252], 'Landolfi': [1253], 'Mower': [1255], 'RL,': [1256], 'Steiner': [1257], '1984.': [1259], 'Modification': [1260], 'platelet': [1262, 1510], 'function': [1263], 'arachidonic': [1265], 'acid': [1266], 'bioflavonoids.': [1269], 'Structure–activity': [1270], 'relations.': [1271], '33:': [1274], '1525–1530.': [1275], 'Li': [1276, 1308], 'AH,': [1277], 'Moro': [1278], 'Melman': [1280], 'N,': [1281], 'Ji': [1282], 'Xd,': [1283], 'Jacobson': [1284], 'KA.': [1285], 'Structure−Activity': [1287], 'Relationships': [1288], 'Molecular': [1290], 'Modeling': [1291], '3,': [1293], '5-Diacyl-2,': [1294], '4-dialkylpyridine': [1295], 'Derivatives': [1296], 'Selective': [1298], 'A3': [1299], 'Adenosine': [1300], 'Receptor': [1301], 'Antagonists.': [1302], 'Med': [1304], '41:': [1306], '3186–3201.': [1307], 'Si': [1310], 'Pan': [1312], 'Excipients': [1317], 'enhance': [1318], 'ganciclovir': [1322], 'inhibition:': [1325], 'Assessed': [1326], 'sac': [1332], 'situ': [1335], 'improved': [1337], 'perfusion.': [1339], '403:': [1343], '37–45.': [1344], 'Xu': [1347], 'DM,': [1348], 'Cheng': [1349], 'YY.': [1350], 'Distinct': [1352], 'nitric': [1359], 'oxide': [1360], 'production': [1361], 'from': [1362], 'endothelial': [1363], 'cells.': [1364, 1477], 'Agric': [1366], '56:': [1369], '824–829.': [1370], 'Madsen': [1371], 'JK,': [1372], 'Jensen': [1373, 1375], 'LW.': [1376], 'between': [1380, 1533, 1554], 'cyclosporine': [1381], 'dihydropyridine': [1384], 'calcium': [1385], 'antagonist': [1386], 'felodipine.': [1387], '203–208.': [1393], 'Neerati': [1394], 'Gade': [1396], 'atorvastatin': [1401], 'pharmacodynamics': [1406], 'glyburide': [1408], 'normal': [1410], 'diabetic': [1412], '42:': [1418], '285–289.': [1419], 'Haroled': [1425], 'Peter': [1426], 'PL,': [1427], 'Rajesh': [1428], 'Jawahar': [1430], 'quercetin': [1436, 1534], 'ranolazine': [1441], 'Dev': [1449, 1544], 'Ind': [1450, 1545], '39:': [1452, 1547], '873–879.': [1453], 'Schuetz': [1454, 1458], 'EG,': [1455], 'Beck': [1456], 'WT,': [1457], 'JD.': [1459], 'Modulators': [1461], 'substrates': [1463], 'cytochrome': [1467, 1585], 'coordinately': [1469], 'upregulate': [1470], 'these': [1471], 'proteins': [1472], 'carcinoma': [1476], 'Mol': [1478, 1599], '49:': [1480], '311–318.': [1481], 'Spencer': [1482], 'JP.': [1483], 'brain': [1487], 'health:': [1488], 'underpinned': [1491], 'common': [1493], 'mechanisms.': [1494], 'Genes': [1495], '4:': [1497], '243–250.': [1498], 'Tzeng': [1499], 'SH,': [1500], 'Ko': [1501, 1503], 'WC,': [1502], 'FN,': [1504], 'Teng': [1505], 'CM.': [1506], 'Inhibition': [1508], 'aggregation': [1511], 'some': [1513], 'flavonoids.': [1514], 'Thromb': [1515], '64:': [1517], '91–100.': [1518], 'Venkatesh': [1519], 'RC,': [1520], 'PR,': [1522], 'Challa': [1523], 'SR,': [1524], 'Johnson': [1525], 'B,': [1526], 'Maheswari': [1527], 'valsartan': [1536], '865–872.': [1548], 'Vlase': [1549], 'L.': [1550], '2010.': [1551, 1677], 'fluoxetine': [1555], 'omeprazole': [1557], 'healthy': [1559], 'male': [1560], 'volunteers.': [1561], 'prospective': [1563], 'pilot': [1564], 'study.': [1565], 'Curr': [1566], '71:': [1569], '360–368.': [1570], 'Wacher': [1571], 'VJ,': [1572], 'CY,': [1574], 'LZ.': [1576], '1995.': [1577], 'Overlapping': [1578], 'substrate': [1579], 'specificities': [1580], 'tissue': [1582], 'distribution': [1583], '3A': [1587], 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[1673], 'Buyse': [1675], 'Cyclooxygenase-2': [1678], 'inhibitors': [1679], 'prevent': [1680], 'trinitrobenzene': [1681], 'sulfonic': [1682], 'acid-induced': [1683], 'up-regulation': [1685], 'vivo.': [1690], '636:': [1694], '189–197.': [1695], 'Citing': [1696], 'Literature': [1697], 'Volume28,': [1698], 'Issue5May': [1699], '2014Pages': [1700], 'ReferencesRelatedInformation': [1702]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2103503721', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-09-08T22:20:15.038961', 'created_date': '2016-06-24'}