Metallochaperones, an Intracellular Shuttle Service for Metal Ions

Name: Work Video:
Duration: 3 min 30 s
Thomas V. O’Halloran; Valeria Culotta
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'locations': [25, 46], 'or': [26, 355, 368, 607, 1001, 1210, 1286, 3116], 'exported': [28], 'to': [29, 44, 141, 158, 301, 351, 435, 503, 547, 709, 731, 807, 974, 985, 988, 1060, 1103, 1107, 1322, 1466, 1472, 1538, 1730, 1794, 1803, 1936, 2030, 2111, 2171, 2210, 2222, 2231, 2255, 2258, 2528, 2648, 2783, 2854, 2871, 3033, 3097, 3340, 3487, 3672, 3680, 3693, 3708, 3721, 3724, 3751, 3841, 3914, 3930, 4030, 4069], 'the': [30, 51, 83, 113, 124, 183, 215, 241, 249, 286, 295, 374, 392, 399, 402, 405, 447, 462, 498, 537, 559, 564, 572, 615, 619, 701, 711, 718, 812, 845, 982, 1114, 1118, 1192, 1195, 1198, 1207, 1218, 1411, 1451, 1550, 1609, 1614, 1623, 1652, 1661, 1665, 1697, 1738, 1783, 1795, 1807, 1811, 1821, 1952, 1956, 2015, 2025, 2032, 2039, 2054, 2065, 2159, 2163, 2172, 2186, 2218, 2232, 2249, 2270, 2336, 2363, 2521, 2529, 2532, 2597, 2642, 2786, 2807, 3099, 3332, 3343, 3346, 3401, 3409, 3488, 3509, 3534, 3540, 3568, 3634, 3640, 3719, 3725, 3744, 3786, 3795, 3842, 3853, 3879, 3882, 3915, 3932, 4023, 4027, 4037, 4040, 4056], 'extracellular': [31, 1211], 'milieu.': [32, 2234], 'A': [33, 67, 370, 1447, 3519], 'key': [34, 533], 'question': [35, 2160], 'then': [36, 1190, 1791, 2243], 'arises:': [37], 'how': [38, 608, 2162], 'specific': [40, 465, 995, 1371], 'metal': [41, 72, 87, 97, 114, 147, 176, 463, 499, 818, 1193, 1542, 1739, 1797, 2102, 2271, 3801, 3883, 3935, 4028], 'transported': [43], 'diverse': [45, 3285], 'and': [47, 111, 134, 185, 441, 464, 500, 524, 566, 651, 703, 713, 756, 796, 1225, 1281, 1355, 1368, 1459, 1565, 1603, 1660, 1736, 1744, 1790, 1820, 1947, 2041, 2048, 2106, 2195, 2215, 2217, 2266, 2300, 2576, 2652, 3094, 3110, 3121, 3287, 3465, 3531, 3593, 3665, 3705, 3731, 3890, 4035, 4046, 4054], 'subsequently': [48], 'sorted': [49], 'into': [50, 550, 558, 614, 839, 1194, 1202, 2346, 2660, 2802, 3036, 3408, 3884], 'correct': [52], 'metalloenzymes?': [53], 'The': [54, 149, 1288, 1531, 1596, 2098, 2174, 2235, 2292, 2340, 2518, 2774, 2862, 3225, 3475, 3923], 'mechanisms': [55, 136], 'by': [56, 232, 360, 649, 999, 1069, 1223, 1293, 1747, 2245, 2326], 'which': [57, 306, 349, 1709, 2053, 2251, 3394, 3738], 'these': [58, 96, 525, 609, 1360], 'tasks': [59], 'accomplished': [61], 'just': [63], 'now': [64, 1638], 'being': [65], 'unraveled.': [66], 'new': [68], 'family': [69, 1312, 3855], 'soluble': [71, 2298], 'receptor': [73], 'proteins': [74, 630, 1635, 2194, 2578, 3857, 3872, 3925], 'known': [75, 1352, 1403, 1537], '“metallochaperones”': [77], 'is': [78, 154, 230, 345, 603, 642, 690, 801, 805, 966, 1407, 1536, 1558, 1561, 1567, 1601, 1637, 2028, 2208, 2220, 2242, 2296, 2437, 2641, 2809, 2851, 2869, 3021, 3031, 3095, 3231, 3238, 3278, 3338, 3498, 3596, 3644, 3711, 3811], 'emerging': [79, 1639], 'act': [81, 980], 'trafficking': [85, 517, 1646, 3802, 3816], 'ions.': [88, 148], 'Although': [89, 2143, 3794], 'elements': [91], 'can': [92, 381, 432, 781, 2149, 2165, 2798, 3294], 'be': [93, 139, 302, 383, 433, 527, 548, 782, 1007, 1054, 2112, 3658, 4070], 'quite': [94, 2113, 3232], 'toxic,': [95, 146], 'receptors': [98], 'not': [100, 358, 604, 1053, 1064, 2810, 3657, 3791, 3928], 'detoxification': [101, 478], 'proteins;': [102], 'they': [103, 3917], 'clearly': [104, 631, 3926], 'function': [105, 2857, 3694, 3929, 3948], '“chaperone-like”': [108], 'manner,': [109], 'guiding': [110], 'protecting': [112], 'ion': [115, 1543, 3537, 3746, 4029], 'while': [116], 'facilitating': [117], 'appropriate': [118], 'partnerships.': [119], 'Here': [120], 'we': [121, 292], 'will': [122, 526], 'review': [123], 'most': [125, 170], 'recent': [126, 233], 'advances': [127], 'our': [129], 'understanding': [130], 'metallochaperones': [133, 153, 494, 2646, 3943, 4021], 'discuss': [135], 'may': [138, 874, 979, 1052, 3123, 3503, 3629, 3656, 3877], 'relevant': [140, 1056], 'other': [142, 2246, 2267, 3820, 3829], 'essential,': [143], 'yet': [144, 3237, 3700, 4068], 'potentially': [145], 'concept': [150], 'relatively': [155], 'new;': [156], 'prior': [157], '1997,': [159], 'there': [160], 'were': [161], 'no': [162, 3669, 3824], 'established': [163, 998], 'molecules': [164, 3283], 'served': [166], 'this': [167, 341, 486, 969, 1350, 1725, 2144, 2205, 2796, 2848, 3019, 3336, 3739], 'function.In': [168], 'vitro,': [169, 3730], 'enzymes': [172, 504, 1204], 'easily': [173], 'acquire': [174, 4059], 'their': [175], 'without': [177], 'an': [178, 196, 222, 237, 252, 633, 691, 1108, 1463, 2182, 2223, 3289, 3481, 3494], 'auxiliary': [179, 223], 'protein.': [180], 'For': [181], 'example,': [182], 'copper-': [184, 2299], 'zinc-dependent': [186], 'enzyme': [187, 535, 2302, 3100], '(SOD1)1': [190], 'binds': [191], 'ionsin': [193], 'vitro': [194], 'with': [195, 721, 789, 909, 1462, 1608, 1703, 1718, 1806, 2019, 2062, 2115, 2192, 2585, 3040, 3070, 3400], 'extraordinarily': [197], 'high': [198], 'affinity': [199], '(K': [200], 'd': [201], '≈': [202], '10−15m).': [203], 'Yet': [204], 'living': [207], 'cell,': [208], 'where': [209, 2263, 4055], 'total': [210, 296, 393, 542], 'concentrations': [212], 'micromolar': [216], 'range,': [217], 'relies': [219], 'heavily': [220], 'upon': [221], 'factor': [224, 3728], 'acquiring': [226, 497], 'copper.': [227], 'This': [228, 426, 468, 1045, 1187, 1626, 2037, 3276], 'paradox': [229], 'resolved': [231], 'observations': [234], 'establish': [236], 'upper': [238], 'limit': [239], 'on': [240, 635, 1714, 1951, 3567, 3702, 3799], 'number': [242, 1621], '“free”': [244, 343], 'ions': [246, 380, 546, 611, 791, 1327, 1819], 'available': [247], 'cytoplasm': [250, 400], 'unstressed': [253], 'cell': [254, 288, 320, 406, 448, 1208, 2808, 3933, 3947], '(1Rae': [255, 321, 407, 3954], 'T.D.': [256, 322, 408, 2672, 2817, 3249, 3300, 3417, 3955], 'Schmidt': [257, 323, 409, 1155, 1577, 1762, 1861, 2077, 3956], 'P.J.': [258, 324, 410, 2745, 2943, 2995, 3045, 3173, 3203, 3957], 'Pufhal': [259, 325, 411, 3958], 'R.A.': [260, 326, 412, 1996, 2674, 2704, 2760, 2819, 2902, 2958, 3132, 3188, 3251, 3302, 3355, 3419, 3959], 'Culotta': [261, 327, 413, 1028, 1081, 1129, 1159, 1235, 1514, 1581, 1766, 1835, 1865, 1969, 2081, 2617, 2681, 2705, 2826, 2903, 2998, 3048, 3133, 3206, 3258, 3309, 3426, 3574, 3614, 3860, 3960, 4002], 'V.C.': [262, 328, 414, 1029, 1082, 1130, 1160, 1236, 1515, 1582, 1767, 1836, 1866, 1970, 2082, 2385, 2443, 2547, 2618, 2682, 2706, 2827, 2904, 2999, 3049, 3134, 3207, 3259, 3310, 3427, 3575, 3615, 3861, 3961, 4003], "O'Halloran": [263, 329, 415, 1079, 1127, 1163, 1585, 1680, 1770, 1833, 1869, 1967, 1997, 2085, 2125, 2274, 2679, 2707, 2761, 2824, 2905, 2959, 3135, 3189, 3256, 3307, 3356, 3424, 3962, 4000], 'T.V.': [264, 330, 416, 1080, 1128, 1164, 1586, 1681, 1771, 1834, 1870, 1968, 1998, 2086, 2126, 2275, 2680, 2708, 2762, 2825, 2906, 2960, 3136, 3190, 3257, 3308, 3357, 3425, 3963, 4001], 'Science.': [265, 276, 331, 417, 593, 1165, 1178, 1587, 1772, 1871, 2087, 3964], '1999;': [266, 277, 332, 418, 1086, 1495, 1840, 1895, 1918, 1974, 2000, 2686, 2714, 2831, 2912, 3003, 3053, 3142, 3211, 3263, 3314, 3376, 3431, 3549, 3620, 3965], '284:': [267, 278, 333, 419, 3966], '805-808Crossref': [268, 334, 420, 3967], 'PubMed': [269, 280, 335, 421, 597, 670, 685, 750, 770, 832, 864, 901, 938, 960, 1040, 1094, 1142, 1169, 1182, 1250, 1276, 1340, 1392, 1441, 1503, 1526, 1591, 1689, 1776, 1848, 1875, 1898, 1926, 1982, 2008, 2091, 2138, 2287, 2317, 2379, 2407, 2422, 2465, 2569, 2635, 2694, 2717, 2750, 2769, 2839, 2915, 2948, 2967, 2989, 3011, 3061, 3089, 3145, 3178, 3197, 3219, 3271, 3322, 3364, 3384, 3439, 3557, 3588, 3623, 3775, 3968, 3989, 4015], 'Scopus': [270, 281, 336, 422, 598, 671, 686, 751, 771, 833, 865, 902, 939, 961, 1041, 1095, 1143, 1170, 1183, 1251, 1277, 1341, 1393, 1442, 1504, 1527, 1592, 1690, 1777, 1849, 1876, 1899, 1927, 1983, 2009, 2092, 2139, 2288, 2380, 2408, 2423, 2466, 2570, 2636, 2695, 2718, 2751, 2770, 2840, 2916, 2949, 2968, 2990, 3012, 3062, 3090, 3146, 3179, 3198, 3220, 3272, 3323, 3365, 3385, 3440, 3558, 3589, 3624, 3776, 3969, 3990, 4016], '(1409)': [271, 337, 423, 3970], 'Google': [272, 283, 338, 424, 600, 673, 688, 753, 773, 835, 867, 904, 941, 963, 1043, 1097, 1145, 1172, 1185, 1253, 1279, 1343, 1395, 1444, 1506, 1529, 1594, 1692, 1779, 1851, 1878, 1901, 1929, 1985, 2011, 2094, 2141, 2290, 2318, 2382, 2410, 2425, 2468, 2572, 2638, 2697, 2720, 2753, 2772, 2842, 2918, 2951, 2970, 2992, 3014, 3064, 3092, 3148, 3181, 3200, 3222, 3274, 3325, 3367, 3387, 3442, 3560, 3591, 3626, 3778, 3971, 3992, 4018], 'Scholar,': [273, 942, 1146, 1173, 1254, 1507, 1852, 1879, 1902, 1986, 2383, 2411, 2469, 2698, 2721, 2754, 2896, 2919, 2952, 2971, 2993, 3149, 3182, 3201, 3368, 3443, 3993], '2Lippard': [274], 'S.J.': [275, 1122, 1154, 1230, 1513, 1576, 1761, 1860, 2076, 3995], '748-749Crossref': [279], '(76)': [282], 'Scholar).': [284, 339, 425, 601, 754, 836, 868, 905, 964, 1044, 1098, 1186, 1344, 1396, 1530, 1595, 1693, 1780, 1930, 2142, 2291, 2319, 2426, 2517, 2573, 2639, 2773, 2843, 3015, 3065, 3275, 3326, 3388, 3474, 3561, 3779, 3868, 3904, 4019], 'Employing': [285], 'yeast': [287, 702, 840, 1025, 1216, 1532, 2357, 2522, 2575], 'model,': [291], 'have': [293, 519, 632, 775, 1674, 2579, 3390, 3504, 3790, 3832, 3848, 3873, 4067], 'estimated': [294], 'cytoplasmic': [297], 'free': [298, 317, 377, 397, 430], 'concentration': [300, 460], 'less': [303, 312, 388], 'than': [304, 313, 389, 3830], '10−18m,': [305], 'represents': [307], 'many': [308], 'orders': [309], 'magnitude': [311], 'one': [314], 'atom': [315, 2493], 'per': [319, 2496], 'In': [340, 1694, 1723, 2202, 3937], 'usage,': [342], 'thermodynamic': [347, 2099, 2261], 'term,': [348], 'corresponds': [350], 'aquo': [352], '(hydrated)': [353], 'Cu(I)': [354, 790, 1610, 2033, 2050, 2117, 2151, 2190, 2257], 'Cu(II)': [356], 'complexes': [357], 'coordinated': [359, 2055], 'tight': [361, 442, 1733, 2154], 'binding': [362, 443, 2155, 3750, 4051], 'ligands': [363, 920], 'such': [364, 480, 991, 1751, 3653, 3784, 3851, 3887, 3908, 4065], 'amino': [366, 1552, 1563, 3235], 'acids': [367], 'biopolymers.': [369], 'similar': [371, 1400, 1705], 'conclusion': [372], 'regarding': [373, 3508], 'scarcity': [375], 'also': [382, 843, 875, 1301, 1934], 'derived': [384], 'kinetic': [386], 'terms;': [387], '0.01%': [390], 'cellular': [394, 489], 'becomes': [396, 472], 'during': [401, 3101], 'lifetime': [403], 'apparent': [427], 'absence': [428], 'attributed': [434], 'moderate': [440], 'chelation': [444, 470], 'sites': [445, 458, 3843], 'including': [449, 915, 2785], 'nonspecific': [450], 'small': [451, 3233], 'molecule': [452, 1465, 2794, 3039], 'interactions,': [453], 'well': [455], 'vesicular': [457], 'proteins.': [467, 705, 1647], 'capacity': [471, 3720], 'even': [473], 'more': [474], 'potent': [475], 'when': [476, 606], 'systems': [479, 788], 'metallothioneins': [482], 'induced.': [484], 'Despite': [485], 'backdrop': [487], 'overcapacity': [490], 'chelation,': [493], 'succeed': [495], 'donating': [501], 'it': [502, 507, 2157, 2184, 3810], 'need': [506], '(depicted': [508], 'Fig.': [510], '1).': [511], 'Thus': [512, 3822], 'far,': [513, 3823], 'three': [514, 544, 2661], 'distinct': [515, 2663], 'pathways': [518, 3817], 'been': [520, 1283, 1455, 1675, 1728, 1801, 2109, 2538, 2580, 3391, 3539, 3675, 3684, 3735, 3792, 3833, 3849, 3874], 'described': [521, 3685, 3875], 'copper,': [523], 'discussed': [528], 'independently.': [529], 'Cytochrome': [530], 'oxidase,': [531, 914, 976], 'mitochondrial': [534, 850, 989], 'respiratory': [538], 'chain,': [539], 'requires': [540, 844, 1048, 2348], 'inserted': [549, 613], 'two': [551, 629, 916, 1347, 1545, 1710], 'subunits:': [552], 'binuclear': [554], 'site': [556, 569, 1598, 1735, 1824, 3411, 3490], 'protruding': [557], 'inner': [560, 573, 714, 851], 'membrane': [561, 574, 715, 852, 1324], 'space': [562, 716], 'mitochondria': [565, 732], 'mononuclear': [568], 'buried': [570], 'within': [571], '(3Tsukihara': [575], 'T.': [576, 582, 1076, 1426, 1428, 1475, 1830, 1964, 2676, 2821, 3253, 3304, 3421], 'Aoyama': [577], 'H.': [578, 584, 1511, 2477, 2506, 2729, 2885, 2927, 3157], 'Yamashita': [579], 'E.': [580, 1509, 3460], 'Tomizaki': [581], 'Yamaguchi': [583], 'Shinzawa-Itho': [585], 'K.': [586, 1908], 'Hakashima': [587], 'R.': [588, 590, 675, 1124, 1148, 1422, 1570, 1755, 1854, 2070, 2391, 2449, 2553, 3449, 3997], 'Yaono': [589], 'Yoshikawa': [591], 'S.': [592, 1027, 1035, 1333, 1436, 1485, 1893, 2630, 3468, 3583], '1995;': [594, 1037, 1337, 1438, 2376], '269:': [595], '1069-1074Crossref': [596], '(1304)': [599], 'It': [602, 800, 965, 3497], 'clear': [605], 'enzyme;': [616, 2183], 'however,': [617, 2791, 3335, 3835], 'among': [618, 1303, 3281], 'host': [620], 'assembly': [622, 3847], 'factors': [623, 990, 4066], 'required': [624], 'cytochrome': [626, 841, 882, 913, 975], 'oxidase': [627, 842, 883], 'activity,': [628, 2595], 'effect': [634], 'utilization.': [637], 'One': [638], 'these,': [640], 'COX17,': [641, 646], 'candidate': [644], 'metallochaperone.': [645, 3715], 'originally': [647, 1010, 3691], 'discovered': [648], 'Tzagoloff': [650, 657, 678, 737, 888, 925, 947, 3976], 'co-workers': [652, 757], '(4Glerum': [653], 'D.M.': [654, 677, 736, 885, 924, 944, 3973], 'Shtanko': [655, 886, 945, 3974], 'A.': [656, 658, 679, 738, 887, 889, 926, 946, 948, 1036, 1126, 1424, 1437, 1491, 1894, 1912, 2473, 2502, 2631, 2881, 3374, 3463, 3584, 3975, 3977, 3999], 'J.': [659, 734, 739, 890, 922, 927, 949, 1083, 1131, 1239, 1265, 1837, 1915, 1971, 2127, 2276, 2308, 2369, 2389, 2396, 2417, 2447, 2454, 2482, 2511, 2551, 2558, 2622, 2678, 2683, 2823, 2828, 2890, 2978, 3000, 3050, 3078, 3208, 3255, 3260, 3306, 3311, 3423, 3428, 3454, 3467, 3573, 3618, 3898, 3978, 4004], 'Biol.': [660, 740, 891, 928, 950, 1084, 1132, 1240, 1266, 1685, 1838, 1916, 1972, 2128, 2277, 2309, 2397, 2455, 2559, 2684, 2713, 2829, 2911, 2979, 3001, 3051, 3079, 3141, 3209, 3261, 3312, 3429, 3864, 3979, 4005], 'Chem.': [661, 741, 892, 929, 951, 1085, 1133, 1241, 1267, 1684, 1839, 1917, 1973, 2129, 2278, 2310, 2398, 2456, 2484, 2513, 2560, 2685, 2830, 2892, 2980, 3002, 3052, 3080, 3210, 3262, 3313, 3430, 3900, 3980, 4006], '1996;': [662, 893, 952, 3981], '271:': [663, 894, 953, 3982], '14504-14509Abstract': [664, 3983], 'Full': [665, 667, 745, 747, 896, 898, 933, 935, 955, 957, 1089, 1091, 1137, 1139, 1245, 1247, 1271, 1273, 1389, 1498, 1500, 1843, 1845, 1921, 1923, 1977, 1979, 2003, 2005, 2133, 2135, 2282, 2284, 2314, 2402, 2404, 2460, 2462, 2564, 2566, 2689, 2691, 2834, 2836, 2984, 2986, 3006, 3008, 3056, 3058, 3084, 3086, 3214, 3216, 3266, 3268, 3317, 3319, 3379, 3381, 3434, 3436, 3552, 3554, 3770, 3772, 3984, 3986, 4010, 4012], 'Text': [666, 668, 746, 748, 897, 899, 934, 936, 956, 958, 1090, 1092, 1138, 1140, 1246, 1248, 1272, 1274, 1390, 1499, 1501, 1844, 1846, 1922, 1924, 1978, 1980, 2004, 2006, 2134, 2136, 2283, 2285, 2315, 2403, 2405, 2461, 2463, 2565, 2567, 2690, 2692, 2835, 2837, 2985, 2987, 3007, 3009, 3057, 3059, 3085, 3087, 3215, 3217, 3267, 3269, 3318, 3320, 3380, 3382, 3435, 3437, 3553, 3555, 3771, 3773, 3985, 3987, 4011, 4013], 'PDF': [669, 749, 900, 937, 959, 1093, 1141, 1249, 1275, 1391, 1502, 1847, 1925, 1981, 2007, 2137, 2286, 2316, 2406, 2464, 2568, 2693, 2838, 2988, 3010, 3060, 3088, 3218, 3270, 3321, 3383, 3438, 3556, 3774, 3988, 4014], '(413)': [672, 3991], 'Scholar,5Amaravadi': [674], 'Glerum': [676, 735, 923], 'Hum.': [680], 'Genet.': [681, 860, 1385], '1997;': [682, 742, 930, 1134, 1166, 1179, 1242, 1588, 1773, 1872, 2088, 2399, 2457, 2561, 3901, 4007], '99:': [683], '329-333Crossref': [684], '(135)': [687], 'Scholar),': [689, 3627], '8.0-kDa': [692], 'protein': [693, 727, 853, 984, 1414, 1615, 2664], 'bearing': [694], '6': [695], 'cysteines': [696, 2056, 2063], 'conserved': [699, 814, 917, 1302, 2598, 3280], 'human': [704, 1219, 1372, 2533, 2577, 3017, 3501], 'Yeast': [706, 1397, 2427], 'COX17': [707, 780, 804, 978, 2653, 3655], 'localizes': [708], 'both': [710, 1742], 'cytosol': [712], 'mitochondria,': [719], 'consistent': [720], 'role': [723, 878], 'shuttle': [726, 983, 1105], 'delivering': [729], '(6Beers': [733, 921], '272:': [743, 931, 1135, 1243, 2400, 2458, 2562, 4008], '33191-33196Abstract': [744, 932], '(207)': [752, 940], 'Winge': [755, 764, 826], '(7Srinivasan': [758, 820], 'C.': [759, 821, 1150, 1158, 1572, 1580, 1757, 1765, 1856, 1864, 1906, 2072, 2080], 'Posewitz': [760, 822], 'M.C.': [761, 823], 'George': [762, 824], 'G.N.': [763, 825], 'D.R.': [765, 827], 'Biochemistry.': [766, 828, 2746, 2765, 2944, 2963, 3174, 3193, 3360], '1998;': [767, 829, 1268, 1523, 2419, 2485, 2514, 2893, 2981, 3081, 3585], '37:': [768, 830], '7572-7577Crossref': [769, 831], '(100)': [772, 834], 'Scholar)': [774, 1280, 1445, 2012, 2095, 2488, 3093, 3223, 3592], 'shown': [776, 1729, 1802, 2110], 'copper-loaded': [779], 'isolated': [783, 1222], 'from': [784, 1062, 1319, 1741, 1745, 2024, 2152, 3284, 3480, 3525, 3533, 3805, 3934, 3939, 4043], 'Escherichia': [785], 'coli': [786], 'expression': [787], 'bound': [792, 1624, 2337, 3535], 'sulfide': [795], 'cysteine': [797, 1546, 2023], 'thiolate': [798], 'cluster.': [799], 'noteworthy': [802, 3499], 'predicted': [806, 3339], 'require': [808], 'only': [809, 2852, 3949], 'four': [810], 'six': [813], 'cysteinyl': [815, 919], 'residues': [816, 1547, 1950], 'coordination': [819, 1620, 1629, 3483], 'Copper': [837], 'incorporation': [838], 'presence': [846], 'SCO1,': [848, 873], '(8Schulze': [854], 'M.': [855, 1481, 1883, 2997, 3047, 3205, 3370, 3372, 3605, 3609, 3761], 'Rodel': [856], 'G.': [857, 1260], 'Mol.': [858, 3862], 'Gen.': [859], '1989;': [861], '216:': [862], '37-43Crossref': [863], '(81)': [866], 'SCO2,': [869], 'homologue': [871, 1220, 2534, 3671, 3679], 'play': [876, 3630], 'activation': [880, 2187, 2603], '(9Glerum': [884], '20531-20535Abstract': [895, 954], '(281)': [903, 962], 'SCO1': [906], 'shares': [907], 'homology': [908, 2782, 3020, 3707], 'subunit': [910], '2': [911], 'copper-binding': [918, 2788], '9Glerum': [943], 'possible': [967], 'region': [970], 'directly': [971, 3405], 'transfers': [972], 'whereas': [977], 'deliver': [986], 'SCO1/SCO2.': [993], 'Until': [994], 'partnerships': [996], 'biochemical': [1000], 'genetic': [1002], 'means,': [1003], 'alternative': [1004, 4050], 'models': [1005, 3545], 'cannot': [1006], 'excluded.': [1008, 3793], 'We': [1009, 2844], 'identified': [1011, 1456, 2355, 2539, 2647], 'ATX1(anti-oxidant)': [1012], '1995': [1014], 'gene': [1017, 2360], 'afforded': [1019], 'protection': [1020, 1047], 'against': [1021, 2198, 2323], 'oxidative': [1022, 2324], 'damage': [1023, 2325], '(10Lin': [1026], 'Proc.': [1030, 1431, 1888, 2625, 3578], 'Natl.': [1031, 1432, 1889, 2626, 3579], 'Acad.': [1032, 1433, 1890, 2627, 3580], 'Sci.': [1033, 1434, 1891, 2628, 3581, 3766], 'U.': [1034, 1435, 1892, 2629, 3582], '92:': [1038, 1439], '3784-3788Crossref': [1039], '(242)': [1042], 'anti-oxidant': [1046], 'ATX1': [1049, 1100, 1294, 1533, 1551, 1600, 1673, 1799, 1933, 1946, 2058, 2105, 2148, 2179, 2214, 2651, 3681], 'overproduction': [1050], 'but': [1051, 1636, 2489, 3668, 3920], 'physiologically': [1055], 'because': [1057], 'activity': [1058, 3043], 'appears': [1059, 1935], 'result': [1061, 2145], 'stoichiometric,': [1063], 'catalytic,': [1065], 'consumption': [1066], 'Cu-ATX1': [1070, 1784], '(11Portnoy': [1071, 1825, 1959], 'M.E.': [1072, 1826, 1960], 'Rosenzweig': [1073, 1827, 1961, 2709, 2763, 2907, 2961, 3137, 3191, 3358], 'A.C.': [1074, 1679, 1828, 1962, 1988, 2710, 2764, 2908, 2962, 3138, 3192, 3359], 'Rae': [1075, 1829, 1963, 2671, 2816, 3248, 3299, 3416], 'Huffman': [1077, 1831, 1965, 1989], 'D.L.': [1078, 1832, 1966, 1990, 2124, 2273, 2620], '274:': [1087, 1841, 1919, 1975, 2687, 2832, 3004, 3054, 3212, 3264, 3315, 3432], '15041-15045Abstract': [1088, 1842, 1976], '(128)': [1096, 1850, 1984], 'Subsequently,': [1099], 'was': [1101, 1221, 1631, 2353, 3329, 3690], 'found': [1102], 'specifically': [1104, 1786], 'transporter': [1111, 1189, 1402, 1453, 1813, 1958, 2067], 'located': [1112], 'Golgi': [1115, 1199], 'compartment': [1116, 2262], 'secretory': [1119], 'pathway': [1120], '(12Lin': [1121], 'Pufahl': [1123, 1995, 2673, 2703, 2759, 2818, 2901, 2957, 3131, 3187, 3250, 3301, 3354, 3418, 3996], 'Dancis': [1125, 1423, 1490, 3998], '9215-9220Abstract': [1136, 4009], '(359)': [1144, 4017], '13Pufahl': [1147, 1853], 'Singer': [1149, 1571, 1756, 1855, 2071], 'Peariso': [1151, 1573, 1758, 1857, 2073], 'K.L.': [1152, 1574, 1759, 1858, 2074], 'Lin': [1153, 1229, 1512, 1575, 1760, 1859, 2075], 'P.': [1156, 1483, 1578, 1763, 1862, 2078, 2670, 2815, 3247, 3298, 3415, 3457], 'Fahrni': [1157, 1579, 1764, 1863, 2079], 'Penner-Hahn': [1161, 1583, 1768, 1867, 2083], 'J.E.': [1162, 1584, 1769, 1868, 2084, 2731, 2929, 3159], '278:': [1167, 1180, 1589, 1774, 1873, 2089], '853-856Crossref': [1168, 1590, 1775, 1874, 2090], '(604)': [1171, 1593, 1778, 1877, 2093], '14Valentine': [1174], 'J.S.': [1175, 2481, 2510, 2743, 2889, 2941, 3171], 'Gralla': [1176, 2478, 2507, 2886], 'E.B.': [1177, 2479, 2508, 2887], '817-818Crossref': [1181], '(192)': [1184], 'pumps': [1191], 'lumen': [1196], 'insertion': [1201, 2343, 3880], 'destined': [1205], 'surface': [1209], 'environment.': [1212], 'Following': [1213], 'identification': [1214, 2519], 'ATX1,': [1217, 1651, 1724, 2784, 3709], 'Gitlin': [1224, 1237, 1263, 1886, 2394, 2452, 2556, 2623, 2976, 3076], 'colleagues': [1226], '(15Klomp': [1227], 'L.W.J.': [1228, 1885], 'Yuan': [1231], 'D.': [1232, 1904, 2610, 2975, 3075, 3547, 3613], 'Klausner': [1233, 1429], 'R.D.': [1234, 1430], 'J.D.': [1238, 1264, 1887, 2395, 2453, 2557, 2624, 2977, 3077, 3603], '9221-9226Abstract': [1244], '(317)': [1252], '16Hung': [1255], 'I.H.': [1256], 'Casareno': [1257, 2390, 2448, 2552], 'R.L.B.': [1258], 'Labesse': [1259], 'Mathews': [1261], 'F.S.': [1262], '273:': [1269, 2982, 3082], '1749-1754Abstract': [1270], '(131)': [1278], 'has': [1282, 1454, 1727, 1800, 2017, 2108, 3538, 3674, 3683, 3718, 3734, 3803], 'denoted': [1284, 2581], 'HAH1': [1285], 'ATOX1.': [1287], 'targets': [1289, 1671, 3781], 'delivery': [1292, 3838, 4025], 'P-type': [1296, 1796], 'transporters': [1298, 1306, 1362, 1667], 'eukaryotes.': [1304], 'These': [1305], 'members': [1308], 'large': [1311], 'transporting': [1314], 'ATPases': [1315], 'use': [1317], 'energy': [1318], 'ATP': [1320, 2253], 'hydrolysis': [1321, 2254], 'drive': [1323], 'transport': [1325], '(reviewed': [1328, 1377, 3753, 3893], 'Ref.17Vulpe': [1330], 'C.D.': [1331], 'Packman': [1332], 'Annu.': [1334], 'Rev.': [1335], 'Nutr.': [1336], '15:': [1338], '293-322Crossref': [1339], '(245)': [1342], 'Humans': [1345], 'express': [1346, 1398, 2431, 3662], 'forms': [1348], 'transporter,': [1351, 2250], 'ATP7A': [1354], 'ATP7B.': [1356], 'Inherited': [1357], 'mutations': [1358, 3528], 'responsible': [1364], 'Menkes': [1366], 'syndrome': [1367], "Wilson's": [1369], 'disease,': [1370, 3513], 'disorders': [1373], 'metabolism': [1376], 'Ref.': [1379, 3755, 3895], '18Bull': [1380], 'P.C.': [1381, 2608, 3617], 'Cox': [1382], 'D.W.': [1383, 3577, 3611], 'Trends': [1384, 3764], '1994;': [1386], '10:': [1387], '246-252Abstract': [1388], '(283)': [1394], 'CCC2': [1405, 2107], 'needed': [1408, 2853, 3747], 'activating': [1410, 3242], 'FET3': [1412], 'involved': [1415, 2361], 'iron': [1417, 3840], 'uptake': [1418], '(19Yuan': [1419], 'D.S.': [1420], 'Stearman': [1421], 'Dunn': [1425], 'Beeler': [1427], '2632-2636Crossref': [1440], '(396)': [1443], '(Fig.1).': [1446], 'plant': [1448, 1468], 'version': [1449], 'RAN1': [1458], 'functions': [1460, 2180], 'together': [1461], 'ATX1-like': [1464, 1808, 2849], 'modulate': [1467], 'growth': [1469], 'response': [1471], 'ethylene': [1473], '(20Hirayama': [1474], 'Kieber': [1476], 'J.J.': [1477, 2475, 2504, 2883], 'Hirayama': [1478], 'N.': [1479], 'Kogan': [1480], 'Guzman': [1482], 'Nourizadeh': [1484], 'Alonso': [1486], 'J.M.': [1487, 2305], 'Dailey': [1488], 'W.P.': [1489], 'Ecker': [1492], 'J.R.': [1493, 2612], 'Cell.': [1494, 3863], '97:': [1496, 2633], '383-393Abstract': [1497], '(324)': [1505], '21Himelblau': [1508], 'Mira': [1510], 'Penarrubia': [1516], 'L.': [1517, 2387, 2445, 2549, 2614, 3859], 'Amasino': [1518], 'R.M.': [1519], 'Plant': [1520], 'Physiol.': [1521], '(Bethesda).': [1522], '117:': [1524], '1227-1234Crossref': [1525], '(176)': [1528], 'bind': [1539, 3295], 'single': [1541, 2492, 2655, 3026], 'via': [1544], 'present': [1548, 2175, 3911], 'acid': [1553], 'sequence': [1554, 3704], 'MXCXXC': [1555, 1822, 2787], '(where': [1556], 'M': [1557], 'methionine,': [1559], 'X': [1560], 'any': [1562], 'acid,': [1564], 'C': [1566], 'cysteine)': [1568], '(13Pufahl': [1569, 1754, 2069], 'metal-binding': [1597, 1662, 1721], 'flexible': [1602], 'accommodates': [1604], 'additional': [1605], 'bonding': [1606], 'interactions': [1607, 1939], 'atom,': [1611], 'indicating': [1612], 'readily': [1616], 'allows': [1617], 'changes': [1618], 'metal.': [1625], 'type': [1627], 'environment': [1630, 3484], 'unprecedented': [1632], 'common': [1642, 2230], 'feature': [1643], 'Structural': [1648], 'studies': [1649, 3806, 3940], '(CCS),': [1657], 'bacterial': [1658], 'CopZ,': [1659, 3783], 'domains': [1663, 1809, 2068, 2247, 2665], 'serve': [1669], 'reviewed': [1676], 'elsewhere': [1677], '(22Rosenzweig': [1678], 'Curr.': [1682], 'Opin.': [1683], '2000;': [1686, 2130, 2279, 2632, 2747, 2766, 2945, 2964, 3175, 3194, 3361, 3767, 3865], '4:': [1687], '140-147Crossref': [1688], '(175)': [1691], 'all': [1695], 'cases,': [1696], 'polypeptides': [1698], 'adopt': [1699], 'βαββαβ': [1701], 'fold': [1702, 1726], 'tertiary': [1706], 'structure': [1707], 'α-helices': [1711], 'superimposed': [1713], '4-stranded': [1716], 'β-sheet': [1717], 'solvent-exposed': [1720], 'site.': [1722, 2789], 'provide': [1731, 2166], 'Cu(I)-binding': [1734], 'protects': [1737, 2321], 'center': [1740, 2034], 'oxidants': [1743], 'capture': [1746], 'excess': [1748, 2224], 'competing': [1749], 'thiols': [1750], 'glutathione': [1753], 'How': [1781, 4053], 'does': [1782], 'complex': [1785], 'recognize,': [1787], 'dock': [1788], 'with,': [1789], 'transfer': [1792, 2191, 2241, 3126, 3740], 'transporter?': [1798], 'physically': [1804, 3068], 'interact': [1805], 'through': [1814, 2332], 'process': [1816, 4038], 'involving': [1817], '23Hamza': [1880], 'I.': [1881, 2307], 'Schaefer': [1882], 'Klomp': [1884, 2386, 2444, 2548], '96:': [1896], '13363-13368Crossref': [1897], '(244)': [1900], '24Larin': [1903], 'Mekios': [1905], 'Das': [1907], 'Ross': [1909], 'B.': [1910, 2393, 2451, 2555, 2735, 2933, 3163], 'Yang': [1911], 'Gilliam': [1913], 'T.C.': [1914], '28497-28504Abstract': [1920], '(152)': [1928], 'Docking': [1931], 'involve': [1937], 'electrostatic': [1938], 'between': [1940, 2104, 2213, 3119], 'positively': [1942], 'charged': [1943, 1949], 'face': [1944], 'negatively': [1948], 'analogous': [1953, 3814], 'segment': [1954], '25Rosenzweig': [1987], 'Hou': [1991], 'M.Y.': [1992], 'Wernimont': [1993, 2701, 2757, 2899, 2955, 3129, 3185, 3352], 'A.K.': [1994, 2702, 2758, 2900, 2956, 3130, 3186, 3353], 'Structure.': [1999, 3375], '7:': [2001, 3377], '605-607Abstract': [2002], '(213)': [2010], '(Fig.2).': [2013], 'Once': [2014], 'metallochaperone': [2016, 2164, 2351, 2523, 3924], 'docked': [2018], 'its': [2020, 2872, 3703, 4031], 'target,': [2021], 'acceptor': [2026], 'domain': [2027, 2656, 2797, 2850, 2864, 3337], 'proposed': [2029, 2846, 3096, 3392, 3692, 3736], 'attack': [2031], 'ATX1.': [2036], 'initiates': [2038], 'formation': [2040, 3111], 'decay': [2042], 'series': [2045], 'two-': [2047], 'three-coordinate': [2049], 'centers': [2051], 'sequentially': [2060], 'replaced': [2061], '(Fig.': [2096], '2).': [2097], 'gradient': [2100], 'exchange': [2103, 2118], 'shallow,': [2114], 'equilibrium': [2119, 2219], 'constant': [2120], '1.4': [2122], '(26Huffman': [2123, 2272], '275:': [2131, 2280], '18611-18614Abstract': [2132, 2281], '(178)': [2140, 2289, 2719, 2917, 3147], 'reveals': [2146], 'release': [2150], 'site,': [2156, 3404], 'begs': [2158], 'sufficient': [2167, 3032], 'flux': [2168], 'transporters.': [2173], 'data': [2176], 'suggest': [2177], 'like': [2181], 'lowers': [2185], 'barrier': [2188], 'partner': [2193], 'perhaps': [2196, 3397], 'discriminates': [2197], 'non-partners': [2199], 'well.': [2201], 'support': [2203], 'notion,': [2206], 'observed': [2209], 'rapidly': [2211], 'equilibrate': [2212], 'CCC2,': [2216], 'insensitive': [2221], 'scavengers': [2227], 'ultimate': [2236], 'driving': [2237], 'force': [2238], 'provided': [2244, 2806], 'remove': [2256], 'separate': [2260], 'multicopper': [2264], 'oxidases': [2265], 'apoproteins': [2268], 'obtain': [2269], 'target': [2293, 2873], 'CCS': [2295, 2589, 2601, 2640, 2658, 2779, 2793, 2856, 2866, 3035, 3122, 3230, 3282, 3502, 3569, 3595, 3628, 3673], 'zinc-requiring': [2301], '(27McCord': [2304], 'Fridovich': [2306], '1969;': [2311], '244:': [2312], '6049-6055Abstract': [2313], 'cells': [2322], 'scavenging': [2327, 3042], 'toxic': [2328], 'anion': [2330], 'radicals': [2331], 'redox': [2333], 'reactions': [2334, 4045], 'at': [2335], 'ion.': [2339], 'vivo': [2342, 3245], 'first': [2354], 'lysine': [2364], 'biosynthetic': [2365], 'pathway,': [2366], 'namelyLYS7': [2367], '(28Horecka': [2368], 'Kinsey': [2370], 'P.T.': [2371], 'Sprague': [2372], 'G.F.': [2373], 'Gene': [2374], '(Amst.).': [2375], '162:': [2377], '87-92Crossref': [2378], '(34)': [2381], '29Culotta': [2384], 'Strain': [2388, 2446, 2550, 2677, 2822, 3254, 3305, 3422, 3572], 'Krems': [2392, 2450, 2554], '23469-23472Abstract': [2401, 2459, 2563], '(696)': [2409, 2467, 2571], '30Gamonet': [2412], 'F.': [2413], 'Lauquin': [2414], 'G.J.-M.': [2415], 'Eur.': [2416], 'Biochem.': [2418, 3470, 3765], '251:': [2420], '716-723Crossref': [2421], '(42)': [2424], 'mutants': [2428, 3565], 'lacking': [2429, 2795], 'LYS7': [2430], 'form': [2433], 'essentially': [2438], 'apo': [2439], '(29Culotta': [2442, 2546], '31Lyons': [2470], 'T.J.': [2471, 2500, 2733, 2879, 2931, 3161], 'Nerissian': [2472, 2501, 2880], 'Goto': [2474, 2503, 2882], 'Zhu': [2476, 2505, 2728, 2884, 2926, 3156], 'Valentine': [2480, 2509, 2742, 2888, 2940, 3170], 'Bioinorg.': [2483, 2512, 2891, 3899], '3:': [2486, 2515, 2894], '650-662Google': [2487, 2516, 2895], 'contains': [2490], 'zinc': [2495, 3666, 3745], 'dimer': [2497], '(31Lyons': [2499, 2878], 'quickly': [2526], 'led': [2527], 'cloning': [2530], 'had': [2536], 'previously': [2537], 'SOD4,': [2541], 'putative': [2543], 'SOD': [2544], 'isoform': [2545], 'Both': [2574], 'CCS.': [2583], 'Mice': [2584], 'targeted': [2586], 'disruptions': [2587], 'exhibit': [2590], 'marked': [2591], 'reductions': [2592], 'emphasizing': [2596], 'requirement': [2599], 'eukaryotic': [2605, 3825], '(32Wong': [2607], 'Waggoner': [2609, 2974, 3074], 'Subramaniam': [2611], 'Tessarollo': [2613], 'Bartnikas': [2615], 'T.B.': [2616], 'Price': [2619, 3612], 'Rothstein': [2621], '2886-2891Crossref': [2634], '(271)': [2637], 'largest': [2643], 'date.': [2649], 'Whereas': [2650], 'represent': [2654], 'proteins,': [2657], 'folds': [2659], 'functionally': [2662], '(Figs.': [2666], '1': [2667], 'and3)': [2668], '(33Schmidt': [2669, 2814, 3246, 3297, 3414], 'Hamma': [2675, 2820, 3252, 3303, 3420], '23719-23725Abstract': [2688, 2833, 3265, 3316, 3433], '(165)': [2696, 2841, 3273, 3324, 3441], '34Lamb': [2699, 2897], 'A.L.': [2700, 2756, 2898, 2954, 3128, 3184, 3351], 'Nat.': [2711, 2909, 3139], 'Struct.': [2712, 2910, 3140], '6:': [2715, 2913, 3143], '724-729Crossref': [2716, 2914, 3144], '35Hall': [2722, 2920, 3150], 'L.T.': [2723, 2921, 3151], 'Sanchez': [2724, 2922, 3152], 'R.J.': [2725, 2923, 3153], 'Holloway': [2726, 2924, 3154], 'S.P.': [2727, 2925, 3155], 'Stine': [2730, 2928, 3158], 'Lyons': [2732, 2930, 3160], 'Demeler': [2734, 2932, 3162], 'Schirf': [2736, 2934, 3164], 'V.': [2737, 2935, 3165], 'Hansen': [2738, 2936, 3166], 'J.C.': [2739, 2937, 3167], 'Nersissian': [2740, 2938, 3168], 'A.M.': [2741, 2939, 3169], 'Hart': [2744, 2942, 3172], '39:': [2748, 2767, 2946, 2965, 3176, 3195, 3362], '3611-3623Crossref': [2749, 2947, 3177], '(45)': [2752, 2950, 3180], '36Lamb': [2755, 2953, 3183], '1589-1595Crossref': [2768, 2966, 3196, 3363], '(87)': [2771, 2969, 3199, 3366], 'N-terminal': [2775, 3347, 3402], 'Domain': [2776, 3029, 3066, 3227, 3327, 3348, 3395], 'I': [2777, 3349], 'bears': [2780], 'striking': [2781], 'Surprisingly,': [2790], 'still': [2799], 'insert': [2800], 'vivo,': [2805], 'starved': [2811], 'therefore': [2845], 'maximize': [2855], 'under': [2858, 3950], 'extreme': [2859], 'copper-limiting': [2860], 'conditions.': [2861], 'central': [2863], '(Domain': [2867], 'II)': [2868], 'homologous': [2870], 'delivery,': [2876], '37Casareno': [2972], 'R.L.': [2973, 3073], '23625-23628Abstract': [2983, 3083], '(204)': [2991, 3091], '38Schmidt': [2994, 3202], 'Ramos-Gomez': [2996, 3046, 3204], '36952-36956Abstract': [3005, 3055, 3213], '(65)': [3013, 3063, 3221], 'With': [3016], 'CCS,': [3018], 'so': [3022], 'strong': [3023], 'mutation': [3027], 'II': [3030, 3067], 'turn': [3034], 'SOD-like': [3038], '(38Schmidt': [3044], 'interacts': [3069], '(37Casareno': [3072], 'secure': [3098], 'insertion.': [3103], 'normally': [3105], 'exists': [3106], 'homodimer,': [3109], 'transient': [3114], 'heterodimer': [3115], 'heterotetramer': [3118], 'precede': [3124], '(34Lamb': [3127], '(Fig.3).': [3224], 'C-terminal': [3226], 'III': [3228, 3328], '(≈30': [3234], 'acids)': [3236], 'extremely': [3239], 'crucial': [3240], 'peptide': [3277], 'highly': [3279], 'species': [3286], 'includes': [3288], 'invariant': [3290], 'CXC': [3291], 'motif': [3292], 'disordered': [3330], 'crystal': [3333], 'structure;': [3334], 'lie': [3341], 'vicinity': [3344], '(36Lamb': [3350], '39Falconi': [3369], 'Iovino': [3371], 'Desideri': [3373], '903-908Abstract': [3378], '(17)': [3386], 'Models': [3389], 'III,': [3396], 'concert': [3399], 'inserts': [3406], 'active': [3410], '40Zhu,': [3444], 'H.,': [3445], 'Shipp,': [3446], 'E.,': [3447, 3455], 'Sanchez,': [3448], 'J.,': [3450, 3458, 3471], 'Liba,': [3451], 'A.,': [3452], 'Stine,': [3453], 'Hart,': [3456], 'Gralla,': [3459], 'B.,': [3461], 'Nersissian,': [3462], 'M.,': [3464], 'Valentine,': [3466], '(2000)': [3469], 'pressGoogle': [3473], 'mechanism': [3476], 'movement': [3479], 'all-sulfur': [3482], '(in': [3485], 'CCS)': [3486], 'all-nitrogen': [3489], 'remains': [3493], 'open': [3495], 'issue.': [3496], 'some': [3505, 3631], 'important': [3506], 'relevance': [3507], 'fatal': [3510], 'motor': [3511], 'neuron': [3512], '(FALS).': [3518], 'subset': [3520], 'FALS': [3522, 3563], 'cases': [3523], 'results': [3524], 'dominantly': [3526], 'inherited': [3527], 'SOD1,': [3530], 'toxicity': [3532], 'designated': [3541], 'culprit': [3542], 'certain': [3544], '(41Cleveland': [3546], 'Neuron.': [3548], '24:': [3550], '515-520Abstract': [3551], '(209)': [3559], 'Because': [3562], 'rely': [3566], '(42Corson': [3570], 'L.B.': [3571, 3607], 'Cleveland': [3576, 3610], '95:': [3586], '6361-6366Crossref': [3587], '(145)': [3590], 'mammalian': [3594], 'abundantly': [3597], 'expressed': [3598], 'neuronal': [3600], 'tissue': [3601], '(43Rothstein': [3602], 'Dykes-Hoberg': [3604], 'Corson': [3606], 'Becker': [3608], 'Wong': [3616], 'Neurochem.': [3619], '72:': [3621], '422-429Crossref': [3622], '(108)': [3625], 'part': [3632], 'etiology': [3635], 'FALS.': [3637], 'Prokaryotes': [3638], 'lack': [3639], 'compartmentalization': [3642], 'typical': [3645], 'eukaryotes;': [3647], 'thus': [3648], 'organelle-specific': [3649], 'carriers': [3650], 'essential.': [3659], 'Furthermore,': [3660, 3869], 'bacteria': [3661], 'SOD,': [3667], 'prokaryotic': [3670, 3870], 'identified.': [3676, 4071], 'However,': [3677], '(CopZ)': [3682], 'enteric': [3687], 'bacteria.': [3688], 'CopZ': [3689, 3710, 3717], 'transcription': [3698, 3727], 'factor;': [3699], 'based': [3701], 'structural': [3706], 'likely': [3713, 3812], 'Purified': [3716], 'donate': [3722], 'CopY': [3726, 3749], 'model': [3733], 'displaces': [3743], 'DNA': [3752], '44Harrison': [3756], 'M.D.': [3757], 'Jones': [3758], 'C.E.': [3759], 'Solioz': [3760], 'Dameron': [3762], 'C.T.': [3763], '25:': [3768], '29-32Abstract': [3769], '(227)': [3777], 'Other': [3780], 'efflux': [3788], 'pump,': [3789], 'bulk': [3796], 'knowledge': [3798], 'emanated': [3804], 'copper-based': [3808], 'systems,': [3809], 'cofactor': [3815], 'exist': [3818], 'metals.': [3821], 'chaperones': [3826, 4057], 'established;': [3834], 'candidates': [3836], 'iron-sulfur': [3845], 'cluster': [3846], 'identified,': [3850], 'IscA': [3854], '(45Jensen': [3858], '20:': [3866], '3919-3927Google': [3867], 'nickel-binding': [3871], 'facilitate': [3878], 'nickel-requiring': [3885], 'enzymes,': [3886], 'urease': [3889], 'cobalt': [3891], 'dehydrogenase': [3892], '46Hausinger': [3896], 'R.P.': [3897], '2:': [3902], '279-286Google': [3903], 'Redox-active': [3905], 'dilemma': [3913], 'cell;': [3916], 'useful': [3919], 'dangerous': [3921], 'cofactors.': [3922], 'do': [3927], 'protect': [3931, 4039], 'toxicity.': [3936], 'fact,': [3938], 'yeast,': [3942], 'become': [3944], 'critical': [3945], 'limitation': [3952], 'conditions': [3953], 'Scholar,4Glerum': [3972], '12Lin': [3994], 'Instead,': [4020], 'ensure': [4022], 'safe': [4024], 'proper': [4032], 'destination': [4034], 'precious': [4041], 'cargo': [4042], 'adventitious': [4044], 'multitude': [4048], 'sites.': [4052], 'themselves': [4058], 'remain': [4061], 'mystery,': [4063]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2103378158', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 33}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 29}, {'year': 2015, 'cited_by_count': 23}, {'year': 2014, 'cited_by_count': 29}, {'year': 2013, 'cited_by_count': 27}, {'year': 2012, 'cited_by_count': 37}], 'updated_date': '2024-12-20T17:52:59.532655', 'created_date': '2016-06-24'}
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