Publication Information

{'id': 'https://openalex.org/W2103229353', 'doi': 'https://doi.org/10.1074/jbc.m205102200', 'title': 'α-Conotoxin GIC from Conus geographus, a Novel Peptide Antagonist of Nicotinic Acetylcholine Receptors', 'display_name': 'α-Conotoxin GIC from Conus geographus, a Novel Peptide Antagonist of Nicotinic Acetylcholine Receptors', 'publication_year': 2002, 'publication_date': '2002-09-01', 'ids': {'openalex': 'https://openalex.org/W2103229353', 'doi': 'https://doi.org/10.1074/jbc.m205102200', 'mag': '2103229353', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12114524'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m205102200', 'pdf_url': 'http://www.jbc.org/article/S0021925820742407/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820742407/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086864255', 'display_name': 'J. Michael McIntosh', 'orcid': 'https://orcid.org/0000-0001-9939-7981'}, 'institutions': [{'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'J. Michael McIntosh', 'raw_affiliation_strings': ['Department of Biology, University of Utah, Salt Lake City, Utah 84112', 'Department of Psychiatry, University of Utah, Salt Lake City, Utah 84112'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, University of Utah, Salt Lake City, Utah 84112', 'institution_ids': ['https://openalex.org/I223532165']}, {'raw_affiliation_string': 'Department of Psychiatry, University of Utah, Salt Lake City, Utah 84112', 'institution_ids': ['https://openalex.org/I223532165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111655395', 'display_name': 'Cheryl Dowell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cheryl Dowell', 'raw_affiliation_strings': ['Department of Biology, University of Utah, Salt Lake City, Utah 84112'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, University of Utah, Salt Lake City, Utah 84112', 'institution_ids': ['https://openalex.org/I223532165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030020858', 'display_name': 'Maren Watkins', 'orcid': 'https://orcid.org/0000-0002-4127-1961'}, 'institutions': [{'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maren Watkins', 'raw_affiliation_strings': ['Department of ‖Pathology, University of Utah, Salt Lake City, Utah 84112'], 'affiliations': [{'raw_affiliation_string': 'Department of ‖Pathology, University of Utah, Salt Lake City, Utah 84112', 'institution_ids': ['https://openalex.org/I223532165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011179506', 'display_name': 'James E. 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Garrett', 'raw_affiliation_strings': ['Cognetix, Inc., Salt Lake City, Utah 84108'], 'affiliations': [{'raw_affiliation_string': 'Cognetix, Inc., Salt Lake City, Utah 84108', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005087507', 'display_name': 'Doju Yoshikami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Doju Yoshikami', 'raw_affiliation_strings': ['Department of Biology, University of Utah, Salt Lake City, Utah 84112'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, University of Utah, Salt Lake City, Utah 84112', 'institution_ids': ['https://openalex.org/I223532165']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002311801', 'display_name': 'Baldomero M. 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Olivera', 'raw_affiliation_strings': ['Department of Biology, University of Utah, Salt Lake City, Utah 84112'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, University of Utah, Salt Lake City, Utah 84112', 'institution_ids': ['https://openalex.org/I223532165']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5086864255'], 'corresponding_institution_ids': ['https://openalex.org/I223532165'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.259, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 109, 'citation_normalized_percentile': {'value': 0.939351, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '277', 'issue': '37', 'first_page': '33610', 'last_page': '33615'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion 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'https://openalex.org/keywords/conus', 'display_name': 'Conus', 'score': 0.5936355}], 'concepts': [{'id': 'https://openalex.org/C2909754679', 'wikidata': 'https://www.wikidata.org/wiki/Q2080426', 'display_name': 'Nicotinic Antagonist', 'level': 4, 'score': 0.87079966}, {'id': 'https://openalex.org/C188987157', 'wikidata': 'https://www.wikidata.org/wiki/Q7030581', 'display_name': 'Nicotinic agonist', 'level': 3, 'score': 0.8570938}, {'id': 'https://openalex.org/C175234850', 'wikidata': 'https://www.wikidata.org/wiki/Q417238', 'display_name': 'Conotoxin', 'level': 3, 'score': 0.74262285}, {'id': 'https://openalex.org/C2779570518', 'wikidata': 'https://www.wikidata.org/wiki/Q412256', 'display_name': 'Nicotinic acetylcholine receptor', 'level': 4, 'score': 0.64568627}, {'id': 'https://openalex.org/C80161118', 'wikidata': 'https://www.wikidata.org/wiki/Q408520', 'display_name': 'Acetylcholine receptor', 'level': 3, 'score': 0.6045364}, {'id': 'https://openalex.org/C2777734688', 'wikidata': 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'level': 1, 'score': 0.09898126}], 'mesh': [{'descriptor_ui': 'D020916', 'descriptor_name': 'Conotoxins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018733', 'descriptor_name': 'Nicotinic Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020916', 'descriptor_name': 'Conotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020916', 'descriptor_name': 'Conotoxins', 'qualifier_ui': 'Q000737', 'qualifier_name': 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3885, 3915, 3933, 3940, 3995, 4001], 'disrupt': [6, 227], 'neuromuscular': [7, 36, 228, 257, 955, 2686, 3935, 4014], 'communication': [8, 229], 'to': [9, 34, 95, 198, 211, 230, 255, 316, 419, 432, 459, 464, 483, 531, 549, 646, 703, 882, 953, 1073, 1175, 1243, 1252, 1285, 1394, 1472, 1529, 1564, 1665, 1677, 1752, 1760, 1821, 1871, 1885, 1889, 1897, 1929, 2002, 2153, 2163, 2231, 2270, 2284, 2414, 2438, 2461, 2468, 2482, 2531, 2705, 2707, 2784, 2890, 2909, 2984, 3036, 3065, 3131, 3176, 3185, 3214, 3257, 3323, 3333, 3581, 3701, 3859, 3926, 4006, 4012], 'paralyze': [10, 231], 'their': [11, 232, 2004, 3174], 'prey.': [12, 233], 'One': [13, 234, 2557, 3992], 'common': [14, 235], 'class': [15, 236], 'of': [16, 169, 237, 390, 477, 524, 669, 680, 686, 697, 719, 781, 786, 799, 849, 900, 907, 909, 914, 926, 995, 1000, 1008, 1060, 1091, 1123, 1138, 1146, 1178, 1185, 1194, 1203, 1211, 1265, 1278, 1459, 1489, 1494, 1517, 1541, 1558, 1631, 1669, 1687, 1738, 1750, 1773, 1795, 1877, 1893, 1908, 1918, 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'on': [30, 104, 251, 325, 457, 817, 1003, 1332, 1351, 1362, 1367, 1947, 2497, 2684, 2744, 2850, 3000, 3044, 3173, 3227, 3572, 3759, 3876, 3899], 'nAChRs': [31, 252, 901, 2733, 2851, 3762, 3936], 'are': [32, 172, 253, 393, 480, 690, 805, 890, 922, 980, 1017, 2064, 2226, 2754, 2806, 3094, 3142, 3514, 3679, 3693, 3744, 3756], 'targeted': [33, 197, 210, 254, 418, 431, 3580], 'the': [35, 98, 105, 118, 127, 134, 167, 179, 199, 212, 218, 256, 319, 326, 339, 348, 355, 388, 400, 420, 433, 439, 492, 507, 546, 633, 681, 704, 717, 720, 779, 782, 787, 797, 845, 850, 885, 891, 915, 937, 954, 1009, 1014, 1022, 1029, 1056, 1065, 1080, 1088, 1107, 1147, 1150, 1176, 1179, 1182, 1189, 1195, 1222, 1233, 1247, 1258, 1270, 1279, 1286, 1290, 1384, 1397, 1445, 1453, 1478, 1495, 1539, 1551, 1739, 1753, 1755, 1816, 1829, 1863, 1869, 1883, 1891, 1913, 1930, 1937, 1989, 2007, 2012, 2023, 2074, 2077, 2086, 2096, 2100, 2119, 2123, 2145, 2149, 2166, 2196, 2219, 2223, 2232, 2242, 2246, 2252, 2262, 2297, 2303, 2311, 2315, 2327, 2332, 2340, 2346, 2374, 2390, 2439, 2453, 2469, 2513, 2522, 2535, 2673, 2685, 2695, 2714, 2727, 2768, 2772, 2794, 2799, 2922, 2943, 2972, 2981, 2985, 3030, 3037, 3051, 3071, 3099, 3105, 3109, 3120, 3133, 3154, 3158, 3188, 3194, 3228, 3283, 3290, 3373, 3383, 3404, 3407, 3412, 3467, 3520, 3527, 3550, 3561, 3610, 3685, 3703, 3748, 3760, 3817, 3877, 3900, 3949, 3968, 3996, 3999, 4020], 'subtype.': [37, 258, 1026, 2774, 3192, 3687], 'The': [38, 51, 65, 259, 272, 286, 522, 666, 920, 929, 1144, 1158, 1200, 1215, 1237, 1274, 1379, 1468, 1505, 1534, 1671, 1735, 1776, 1793, 1873, 2102, 2128, 2354, 2408, 2600, 2752, 2775, 2897, 2934, 2969, 2989, 3025, 3046, 3160, 3168, 3355, 3586, 3641, 3688, 3945], 'toxin': [39, 68, 73, 119, 260, 289, 294, 340, 847, 1183, 1656, 1813, 1835, 1859, 1886, 1968, 2121, 2234, 2255, 2451, 2479, 2721, 2828, 2906, 3033, 3163, 3579], 'characterized': [40, 140, 261, 361, 473, 932, 2273, 2960, 3032, 3073, 3162, 3537], 'in': [41, 76, 86, 113, 182, 190, 262, 297, 307, 334, 403, 411, 650, 716, 808, 946, 1120, 1358, 1521, 1812, 1862, 1981, 2006, 2122, 2229, 2241, 2288, 2452, 2466, 2474, 2569, 2608, 2643, 2756, 2811, 2824, 2853, 2859, 2917, 2942, 3070, 3098, 3113, 3132, 3149, 3153, 3179, 3207, 3217, 3235, 3275, 3348, 3359, 3380, 3406, 3507, 3613, 3635, 3850, 3857, 3960, 3965], 'this': [42, 263, 1052, 1078, 2079, 2289, 2427, 2690, 3114, 3462, 3592, 3619, 3851, 4008], 'report,': [43, 264, 1053, 3463], 'α-conotoxin': [44, 144, 151, 265, 365, 372, 1063, 1082, 1186, 2088, 2150, 2157, 2167, 2197, 2205, 2266, 2369, 2384, 2397, 2432, 2445, 2472, 2519, 2525, 2588, 2629, 2632, 2637, 2656, 2677, 2761, 2779, 2787, 2816, 2834, 2848, 2874, 2886, 2932, 2946, 3038, 3054, 3080, 3201, 3211, 3225, 3286, 3329, 3334, 3397, 3425, 3470, 3486, 3498, 3541, 3553, 3764, 3808, 3863, 3889, 3892, 4023], 'GIC,': [45, 266, 3055, 3864, 3893], 'is': [46, 154, 162, 176, 267, 375, 383, 397, 543, 630, 769, 776, 791, 844, 934, 991, 1936, 2081, 2210, 2238, 2465, 2529, 2781, 2818, 2836, 2876, 3090, 3129, 3203, 3238, 3331, 3345, 3392, 3403, 3427, 3472, 3488, 3544, 3596, 3617, 3645, 3882, 3954, 3994, 4005], 'a': [47, 58, 156, 206, 268, 279, 377, 427, 475, 510, 532, 709, 713, 792, 923, 959, 992, 1061, 1128, 1165, 1333, 1388, 1629, 1685, 1696, 1748, 1899, 1909, 1970, 1982, 1992, 2060, 2110, 2155, 2181, 2399, 2483, 2505, 2860, 2961, 2992, 3136, 3165, 3204, 3276, 3310, 3360, 3500, 3568, 3577, 3623, 3871], 'striking': [49, 270, 3402, 3872, 3914], 'exception.': [50, 271], '16-amino': [52, 273, 2962], 'acid': [53, 274, 1276, 1372, 1543, 2963], 'peptide': [54, 99, 275, 320, 1454, 1480, 1507, 1680, 2309, 2329, 2356, 2400, 2419, 2982, 3101, 3111], 'was': [55, 69, 74, 276, 290, 295, 1104, 1118, 1162, 1219, 1241, 1250, 1328, 1392, 1449, 1470, 1481, 1499, 1511, 1536, 1553, 1605, 1741, 1758, 1768, 1780, 1797, 1819, 1826, 1832, 1836, 1852, 1887, 2054, 2188, 2256, 2259, 2268, 2318, 2349, 2357, 2371, 2742, 2888, 2899, 2925, 2938, 3056, 3252], 'identified': [56, 277], 'from': [57, 62, 278, 283, 474, 491, 632, 684, 692, 778, 796, 905, 936, 988, 1064, 1077, 1101, 1375, 1383, 1603, 1920, 2066, 2170, 2207, 2296, 2310, 2339, 2389, 2402, 2672, 2936, 3087, 3119, 3198, 3605], 'genomic': [59, 280, 1160, 2171, 2176], 'DNA': [60, 281, 1100, 1109, 1161, 1239, 1294, 2177], 'clone': [61, 282, 2203], 'Conus': [63, 284, 990, 1069, 2208], 'geographus.': [64, 285, 1070], 'predicted': [66, 287, 2253], 'mature': [67, 288, 2087, 2120, 2233, 2254], 'synthesized,': [70, 291, 1329], 'and': [71, 166, 205, 292, 387, 426, 557, 664, 784, 812, 911, 917, 944, 968, 1032, 1058, 1132, 1188, 1205, 1246, 1345, 1364, 1369, 1386, 1477, 1492, 1508, 1527, 1550, 1707, 1804, 1823, 1839, 1987, 2041, 2051, 2133, 2190, 2299, 2342, 2345, 2508, 2511, 2521, 2641, 2746, 2758, 2869, 3027, 3145, 3304, 3317, 3344, 3368, 3511, 3696, 3754, 3870, 3891, 3903, 3923], 'synthetic': [72, 293, 2368, 3110], 'used': [75, 296, 482, 505, 643, 878, 1163, 1251, 1393, 1563, 1888, 2926], 'all': [77, 298, 1807, 2271], 'studies': [78, 299], 'described.': [79, 300], 'α-Conotoxin': [80, 301, 2527, 3390, 3517], 'GIC': [81, 145, 302, 366, 2198, 2267, 2370, 2385, 2412, 2433, 2589, 2657, 2678, 2762, 2780, 2817, 2849, 2868, 2875, 2887, 3081, 3212, 3226, 3287, 3330, 3369, 3391, 3487, 3499, 3518, 3554], 'shows': [82, 303], 'no': [83, 101, 304, 322, 1084, 1790, 1848, 2711, 3247, 3897], 'paralytic': [84, 305, 3206, 3243], 'activity': [85, 306, 774, 1086, 2683, 3028, 3314, 3815, 3869, 3875, 3898], 'fish': [87, 308, 1999, 2015, 2498, 2564], 'or': [88, 309, 463, 1681, 1902, 1966, 2109, 2458, 2572, 2631, 2665, 3007, 3220, 3246, 3896], 'mice.': [89, 310], 'Furthermore,': [90, 311], 'even': [91, 312, 3473], 'at': [92, 313, 1021, 1087, 1141, 1628, 1743, 1771, 1921, 1995, 2095, 2534, 3005, 3254, 3315, 3475, 3816], 'concentrations': [93, 314, 3255], 'up': [94, 315, 2706, 3256], '100': [96, 317, 2708, 2884, 2930, 3258], 'μm,': [97, 318], 'has': [100, 120, 321, 341, 1083, 2763, 3082, 3164, 3309, 3338, 3519, 3555, 3811, 3866, 3906], 'detectable': [102, 323, 1085], 'effect': [103, 324], 'human': [106, 128, 327, 349, 1559, 2696, 2731, 2891, 3229, 3476], 'muscle': [107, 200, 328, 421, 705, 1023, 1089, 2536, 2697, 2773, 3189, 3230, 3531, 3551, 3562, 3686, 3749, 3818, 3878, 3901], 'subtype': [110, 201, 215, 331, 422, 436, 1090, 2537, 2698, 3231, 3532, 3750, 3819], 'heterologously': [111, 332, 2693], 'expressed': [112, 333, 2694, 2852, 3234, 3634], 'Xenopus': [114, 335, 1570, 2854, 3236, 3636], 'oocytes.': [115, 336, 1924, 2703], 'In': [116, 337, 1051, 1071, 2073, 2583, 2651, 2717, 2830, 3209, 3461, 3482], 'contrast,': [117, 338, 2584, 2652, 2718, 2831, 3210, 3483], 'high': [121, 342, 447, 2791, 3339, 3509, 3907], 'affinity': [122, 343, 3340, 3908], '(IC50': [123, 344, 3638], '≈1.1': [124, 345], 'nm)': [125, 346], 'for': [126, 347, 644, 1155, 1167, 1172, 1262, 1289, 1474, 1531, 1567, 1764, 1800, 1850, 1868, 1976, 2047, 2212, 2418, 2767, 2793, 2894, 2927, 3108, 3341, 3504, 3524, 3558, 3747, 3909], 'α3β2': [129, 158, 213, 350, 379, 434, 2732, 2745, 2769, 2795, 3291, 3342, 3422, 3477, 3528, 3559, 3632, 3761], 'subunit': [130, 351, 2748, 2770, 2796, 3292], 'combination,': [131, 352], 'making': [132, 353, 3497], 'it': [133, 161, 354, 382, 1095, 1851, 2429, 3035, 3595, 3881], 'neuronally': [136, 357], 'selective': [137, 358, 3547, 3746], 'antagonist': [139, 196, 209, 360, 417, 430], 'thus': [141, 362, 3538], 'far.': [142, 363, 3539], 'Although': [143, 364, 2421, 3365, 3540, 3609], 'shares': [146, 367], 'some': [147, 368, 999], 'sequence': [148, 369, 1193, 2089, 2125, 2169, 2199, 2376, 3026], 'similarity': [149, 370], 'with': [150, 193, 371, 414, 639, 712, 772, 1127, 1135, 1257, 1360, 1546, 1607, 1695, 1789, 1802, 1958, 1965, 1991, 2022, 2033, 2040, 2059, 2085, 2373, 2396, 2489, 2504, 2574, 2622, 2840, 2903, 2965, 2975, 3240, 3296, 3600, 3647, 4019], 'MII,': [152, 373, 2398, 2473, 3335, 3809, 3890], 'which': [153, 374, 1001, 2187, 2475, 2998, 3042, 3336, 3508, 3629, 3810, 3865], 'also': [155, 376, 1658, 2606, 3308, 3337, 3621, 3680, 3806, 3938], 'potent': [157, 378, 3205, 3867], 'antagonist,': [160, 381], 'much': [163, 384, 3393, 3489], 'less': [164, 385, 2644], 'hydrophobic,': [165, 386], 'kinetics': [168, 389, 2800, 2865, 3408, 3689], 'channel': [170, 391], 'block': [171, 392, 1831, 2712, 2802, 2814, 2832, 2872, 2937, 3248, 3410, 3419, 3484, 4013], 'substantially': [173, 394, 2807], 'different.': [174, 395, 2808], 'It': [175, 396, 2258, 3089, 3307, 3912], 'noteworthy': [177, 398], 'ligands': [181, 402], 'C.': [183, 404, 1102, 1403, 2494, 2515, 3199, 3566, 3739, 3804, 3854], 'geographus': [184, 405, 2179, 2495, 2516, 3123, 3855], 'venom': [185, 406, 893, 3616], 'fit': [186, 407, 1928], 'an': [187, 408, 489, 770, 1456, 1514, 1948, 3297, 3352, 3697], 'emerging': [188, 409], 'pattern': [189, 410, 3074], 'predators,': [192, 413], 'one': [194, 415, 1678, 1761, 2108], '(thereby': [202, 423], 'causing': [203, 424], 'paralysis)': [204, 425], 'second': [207, 428, 1496, 2341], 'nAChR': [214, 435, 706, 957, 1560, 2700, 2871], '(possibly': [216, 437], 'inhibiting': [217, 438], 'fight-or-flight': [219, 440, 3969], 'response).': [220, 441], 'N-(9-fluorenyl)methoxycarboxyl': [446], 'performance': [448], 'liquid': [449], 'chromatography': [450], 'employ': [453], 'nAChRs1': [458], 'defend': [460], 'against': [461, 2011], 'predators': [462], 'facilitate': [465], 'prey': [466, 682, 947, 2503], 'capture.': [467], 'Numerous': [468], 'low': [469], 'molecular': [470], 'weight': [471], 'toxins,': [472, 3170, 3862], 'variety': [476, 2993], 'biological': [478, 3946], 'sources,': [479], 'likely': [481], 'discourage': [484], 'consumption': [485], 'by': [486, 499, 527, 707, 879, 948, 1451, 1483, 1502, 1525, 1538, 1555, 1683, 1978, 2009, 2056, 2320, 2330, 2351, 2360, 2499, 2577, 2803, 2815, 2833, 2873, 3424, 3485, 3682], 'predators.': [487], 'Nicotine,': [488], 'alkaloid': [490, 771], 'tobacco': [493, 525, 537], 'plant,': [494], 'causes': [495, 942], 'paralysis': [496, 685, 943, 1977, 2568, 2576, 2596, 2640, 2666, 3178, 3216], 'when': [497, 541], 'ingested': [498], 'insects.': [500], 'Nicotine': [501], 'extracts': [502], 'have': [503, 641, 902, 985, 2415, 2790, 2959, 3127, 3182, 3351, 3894, 3927], 'been': [504, 642, 903, 986, 3085, 3183], 'since': [506], '1900s': [508], 'as': [509, 535, 1164, 1297, 1399, 1572, 1710, 2443, 2612, 3135, 3627], 'natural': [511], 'insecticide': [512], '(1McIndoo': [513], 'N.E.': [514], 'J.': [515, 563, 591, 736, 756, 833, 866, 1311, 1428, 1586, 1647, 1727, 2543, 3445, 3654, 3710, 3769, 3832, 3982], 'Agric.': [516], 'Res.': [517], '1916;': [518], '7:': [519], '89-122Google': [520], 'Scholar).': [521, 678, 767, 842, 875, 978, 1050, 1214, 1326, 1443, 1595, 1654, 1734, 2142, 2556, 3024, 3460, 3673, 3738, 3802, 3847, 3991], 'harvesting': [523], 'plants': [526], 'humans': [528], 'commonly': [529], 'leads': [530], 'syndrome': [533], 'known': [534, 888, 2530, 3522, 3626], 'green': [536], 'sickness.': [538], 'This': [539, 1767, 2464], 'occurs': [540], 'nicotine': [542], 'absorbed': [544], 'through': [545], 'skin,': [547], 'leading': [548], 'weakness,': [550], 'nausea,': [551], 'vomiting,': [552], 'dizziness,': [553], 'abdominal': [554], 'cramps,': [555], 'headache,': [556], 'difficulty': [558], 'breathing': [559], '(2Ballard': [560], 'T.': [561], 'Ehlers': [562], 'Freund': [564], 'E.': [565, 857], 'Auslander': [566], 'M.': [567, 859, 1305], 'Brandt': [568], 'V.': [569], 'Halperin': [570], 'W.': [571, 826, 832], 'Arch.': [572, 619, 3792], 'Environ.': [573, 593, 620], 'Health.': [574, 621], '1995;': [575, 2552, 3778], '50:': [576], '384-389Crossref': [577], 'PubMed': [578, 598, 625, 745, 765, 871, 1046, 1322, 1439, 1591, 1652, 1732, 3456, 3659, 3715, 3734, 3798, 3843, 3987], 'Scopus': [579, 599, 626, 839, 872, 1047, 1323, 1440, 1592, 3021, 3457, 3735, 3799, 3844, 3988], '(54)': [580], 'Google': [581, 601, 628, 746, 766, 841, 874, 1049, 1325, 1442, 1594, 1653, 1733, 2555, 3023, 3459, 3660, 3672, 3716, 3737, 3781, 3801, 3846, 3990], 'Scholar,': [582, 602, 747, 3717], '3Arcury': [583], 'T.A.': [584], 'Quandt': [585], 'S.A.': [586], 'Preisser': [587], 'J.S.': [588, 1419], 'Norton': [589], 'D.': [590, 1405, 1413, 1584, 1642, 1722, 3436, 3823, 3980], 'Occup.': [592], 'Med.': [594], '2001;': [595, 622], '43:': [596], '601-609Crossref': [597], '(50)': [600], "4D'Alessandro": [603], 'A.': [604, 966, 1425], 'Benowitz': [605], 'N.L.': [606], 'Muzi': [607], 'G.': [608, 618], 'Eisner': [609], 'M.D.': [610], 'Filberto': [611], 'S.': [612, 865, 1578, 1580, 1634, 1714, 3440, 3827], 'Fantozzi': [613], 'P.': [614, 654, 662, 725, 731, 735, 753, 755, 1423], 'Montanari': [615], 'L.': [616, 733, 1421], 'Abbritti': [617], '56:': [623], '257-263Crossref': [624], '(19)': [627], 'Scholar).d-Tubocurarine': [629], 'isolated': [631, 691, 777, 795, 904, 987, 1075, 1105, 2401, 2524, 3086, 3117, 3171], 'Chondodendron': [634], 'tomentosum': [635], 'bush.': [636], 'Arrows': [637], 'tipped': [638], 'curare': [640], 'centuries': [645], 'hunt': [647], 'wild': [648], 'game': [649], 'South': [651], 'America': [652, 811], '(5Taylor': [653], 'Gilman': [655], 'A.G.': [656, 1303], 'Rall': [657], 'T.W.': [658], 'Nies': [659], 'A.S.': [660], 'Taylor': [661, 734, 754], 'Goodman': [663], "Gilman's": [665], 'Pharmacological': [667], 'Basis': [668], 'Therapeutics.': [670], '8th': [671], 'Ed.': [672], 'Pergamon': [673], 'Press,': [674, 972], 'New': [675], 'York1990:': [676], '166-186Google': [677], 'Death': [679], 'results': [683, 2460, 2753, 2914], 'skeletal': [687], 'muscles.': [688], 'Lophotoxins': [689], 'Lophogorgia': [693], 'pseudopterogorgia': [694], '(a': [695], 'species': [696, 908], 'soft': [698], 'coral);': [699], 'lophotoxins': [700], 'bind': [701], 'irreversibly': [702], 'forming': [708], 'covalent': [710], 'bond': [711, 3068], 'tyrosine': [714], 'residue': [715], 'α-subunit': [718], '(6Abramson': [722], 'S.N.': [723, 749], 'Culver': [724, 752], 'Kline': [726], 'T.,': [727], 'Li,': [728], 'Y.': [729, 751, 861], 'Guest': [730], 'Gutman': [732], 'Biol.': [737, 757, 1429, 3446, 3729, 3833], 'Chem.': [738, 758, 1430, 3447, 3834], '1988;': [739], '263:': [740], '18568-18573Abstract': [741], 'Full': [742, 762, 1434, 1436, 3451, 3453, 3838, 3840], 'Text': [743, 763, 1435, 1437, 3452, 3454, 3839, 3841], 'PDF': [744, 764, 1438, 3455, 3842], '7Abramson': [748], 'Li': [750], '1989;': [759], '264:': [760], '12666-12672Abstract': [761], 'Erythroidine': [768], 'curare-like': [773], 'seeds': [780, 798], 'trees': [783], 'shrubs': [785], 'genus': [788, 994], 'Erythrina.': [789], 'Methyllycaconitine': [790], 'tertiary': [793], 'diterpenoid': [794], 'Delphinium': [800], 'brownii(the': [801], 'larkspur': [802], 'plant).': [803], 'Larkspurs': [804], 'widely': [806], 'distributed': [807], 'western': [809], 'North': [810], 'they': [813, 2019, 3378, 3964], 'kill': [814], 'more': [815, 2470, 3394, 3490], 'cattle': [816], 'range': [818], 'lands': [819], 'than': [820, 896, 2645, 2941, 3396, 4011], 'any': [821, 1857, 2593, 2661, 2682, 3534], 'other': [822, 1206, 1808, 2134, 2747, 2919, 2976, 3284, 3606], 'poisonous': [823], 'plant': [824], '(8Majak': [825], 'McDiarmid': [827], 'R.E.': [828], 'Hall': [829], 'J.W.': [830], 'Willms': [831], 'Range': [834], 'Mgmt.': [835], '2000;': [836, 1588], '53:': [837, 3670], '207-210Crossref': [838], '(8)': [840], 'Neosurugatoxin': [843], 'primary': [846, 3704], 'component': [848, 925, 1007, 3612, 3625], 'Japanese': [851], 'ivory': [852], 'mollusc,': [853], 'Babylonia': [854], 'japonica': [855], '(9Hayashi': [856], 'Isogai': [858], 'Kagawa': [860], 'Takayanagi': [862], 'N.': [863], 'Yamada': [864], 'Neurochem.': [867], '1984;': [868], '42:': [869], '1491-1494Crossref': [870], '(51)': [873], 'Among': [876], 'capture': [883], 'prey,': [884, 3575], 'well': [887], 'examples': [889], 'snake': [892, 927, 3620], 'polypeptides.': [894], 'More': [895], '90': [897], 'neurotoxin': [898], 'dozens': [906], 'land': [910], 'sea': [912], 'snakes': [913], 'Elapidae': [916], 'Hydrophidae': [918], 'families.': [919], 'α-neurotoxins': [921], 'dominant': [924], 'venoms.': [928], 'extensively': [931], 'α-neurotoxin': [933], 'α-bungarotoxin': [935], 'Taiwanese': [938], 'banded': [939], 'krait.': [940], 'α-Bungarotoxin': [941], 'death': [945, 2052, 2642], 'binding': [949], '(with': [950], 'near': [951], 'irreversibility)': [952], 'junction': [956], '(for': [958], 'review,': [960], 'see': [961], 'Ref.': [962], '10Chiappinelli': [963], 'V.A.': [964], 'Harvey': [965, 3665], 'Natural': [967], 'Synthetic': [969, 2383], 'Neurotoxins.': [970], 'Academic': [971], 'Harcourt': [973], 'Brace': [974], 'Jovanovich,': [975], 'London1993:': [976], '65-109Google': [977], 'α-Conotoxins': [979], 'small': [981], 'disulfide-rich': [982], 'peptides': [983, 1380, 1398, 2225, 3742], 'Conus.': [989], 'large': [993], 'predatory': [996, 3919], 'marine': [997, 1156], 'snails,': [998], 'feed': [1002], 'fish.': [1004, 2514, 3208, 3221], 'A': [1005, 1596, 2202], 'major': [1006, 3195, 3611], 'complex': [1010], 'arsenal': [1012], 'fish-eating': [1015, 1066], 'Conusemploy': [1016], 'Examples': [1027], 'include': [1028], 'α-,': [1030], 'αA-': [1031], 'ψ-conotoxins': [1033], '(11McIntosh': [1034], 'J.M.': [1035, 1576, 1636, 1646, 1716, 1726, 2549, 3011, 3444, 3775, 3783, 3831, 3976], 'Santos': [1036], 'A.D.': [1037], 'Olivera': [1038, 1316, 1426, 1643, 1723, 3012, 3441, 3790, 3828, 3977], 'B.M.': [1039, 1317, 1427, 1644, 1724, 3013, 3442, 3791, 3829, 3978], 'Annu.': [1040], 'Rev.': [1041], 'Biochem.': [1042, 3793], '1999;': [1043, 1431], '68:': [1044], '59-88Crossref': [1045], '(276)': [1048], 'we': [1054, 2422, 2692, 3464], 'describe': [1055], 'cloning': [1057, 1264], 'synthesis': [1059, 2250, 3049, 4021], 'novel': [1062, 2156], 'cone': [1067, 2405], 'snail': [1068], 'contrast': [1072, 2230, 2467], 'previously': [1074, 1299, 1401, 1574, 1711, 2272, 3072, 3181, 3416], 'α-conotoxins': [1076, 2063, 2867, 3118, 3357, 3366], 'species,': [1079], 'new': [1081, 2861, 3052, 3277], 'receptor,': [1092, 3902], 'but': [1093, 3594, 3937], 'instead,': [1094], 'potently': [1096, 3186, 3288, 3630], 'targets': [1097], 'neuronal': [1098, 3525, 3582, 3868], 'nAChRs.': [1099, 1809, 2751, 3045], 'geographushepatopancreas': [1103], 'using': [1106, 1169, 1221, 1342, 1940, 1969, 3059], 'Puregene': [1108], 'Isolation': [1110], 'Kit': [1111], '(Gentra': [1112], 'Systems,': [1113], 'Minneapolis,': [1114], 'MN).': [1115], 'Frozen': [1116], 'tissue': [1117], 'placed': [1119], '600': [1121], 'μl': [1122, 1960, 2035, 2624], 'lysis': [1124], 'buffer,': [1125], 'homogenized': [1126], 'disposable': [1129], 'microcentrifuge': [1130], 'pestle,': [1131], 'digested': [1133], 'overnight': [1134], '60': [1136, 2570], 'μg': [1137], 'proteinase': [1139], 'K': [1140], '55': [1142], '°C.': [1143], 'remainder': [1145], 'procedure': [1148], 'followed': [1149], 'kit': [1151, 1228, 1296], "manufacturer's": [1152, 1234, 1271], 'suggested': [1153, 1235, 1272], 'protocol': [1154, 1288, 1391, 2924], 'invertebrates.': [1157], 'resulting': [1159, 1216, 1248, 1280], 'template': [1166], 'PCR': [1168, 1217, 1225, 2159, 2173], 'oligonucleotides,': [1170], 'tailed': [1171], 'cloning,': [1173], 'corresponding': [1174], '3′-end': [1177], 'intron': [1180], 'preceding': [1181, 1882], 'region': [1184], 'prepropeptides': [1187, 1197], '3′-UTR': [1190], '(untranslated': [1191], 'region)': [1192], 'α': [1196], '(12Schoenfeld': [1198, 2126], 'R.A.': [1199, 2127], 'Genomic': [1201, 2129], 'Structure': [1202, 2130], 'Delta-contoxins': [1204, 2132], 'O-superfamily': [1207, 2135], 'Conotoxins.Ph.D.': [1208, 2136], 'thesis.': [1209, 2137], 'University': [1210, 2138], 'Utah,': [1212, 2140], '1999Google': [1213, 2141], 'product': [1218, 1226, 1249], 'purified': [1220, 1482, 1554, 2358], 'High': [1223], 'Pure': [1224], 'purification': [1227, 2325], '(Roche': [1229], 'Molecular': [1230], 'Biochemicals)': [1231], 'following': [1232, 1269], 'protocol.': [1236], 'eluted': [1238, 2386], 'fragment': [1240], 'annealed': [1242], 'pAMP1': [1244], 'vector,': [1245], 'transfect': [1253], 'competent': [1254], 'DH5α': [1255], 'cells': [1256], 'CloneAmp': [1259], 'pAMP': [1260], 'system': [1261], 'rapid': [1263, 3512], 'amplification': [1266, 2174], 'products': [1267], '(Invitrogen)': [1268], 'protocols.': [1273], 'nucleic': [1275], 'sequences': [1277], 'clones': [1281, 2194], 'were': [1282, 1356, 1374, 1381, 1562, 1693, 1787, 1842, 1927, 1955, 1974, 2000, 2030, 2045, 2161, 2200, 2281, 2294, 2336, 2605, 2619, 2882, 2911, 2915], 'determined': [1283, 2055], 'according': [1284], 'standard': [1287, 1346], 'Sequenase': [1291], 'version': [1292], '2.0': [1293, 1612], 'sequencing': [1295], 'described': [1298, 1400, 1573, 1712, 2613, 3112], '(13Jimenez': [1300], 'E.C.': [1301], 'Craig': [1302, 1424], 'Watkins': [1304], 'Hillyard': [1306], 'D.R.': [1307], 'Gray': [1308, 3437, 3788, 3824], 'W.R.': [1309, 3438, 3789, 3825], 'Gulyas': [1310], 'Rivier': [1312], 'J.E.': [1313, 1582], 'Cruz': [1314, 1410, 3014, 3784], 'L.J.': [1315, 1411, 3015, 3785], 'Biochemistry.': [1318], '1997;': [1319, 3984], '36:': [1320], '989-994Crossref': [1321], '(118)': [1324], 'Peptide': [1327], '0.45': [1330], 'mmol/g,': [1331], 'Fmoc': [1334, 1343], 'amide': [1335], 'resin': [1336, 1385], '(Applied': [1337], 'Biosystems,': [1338], 'catalog': [1339], 'No.': [1340], '401435)': [1341], 'chemistry': [1344], 'side': [1347], 'chain': [1348], 'protection': [1349, 3061], 'except': [1350], 'cysteine': [1352], 'residues.': [1353, 2968], 'Cys': [1354, 2279, 2967, 3063, 3151], 'residues': [1355, 3064, 3152], 'protected': [1357, 2283], 'pairs': [1359], 'eitherS-trityl': [1361], 'Cys2': [1363], 'Cys8': [1365], 'orS-acetamidomethyl': [1366], 'Cys3': [1368], 'Cys16.': [1370], 'Amino': [1371], 'derivatives': [1373], 'Bachem': [1376], '(Torrance,': [1377], 'CA).': [1378], 'removed': [1382, 2295, 2338], 'precipitated;': [1387], 'two-step': [1389], 'oxidation': [1390], 'selectively': [1395, 2533], 'fold': [1396], '(14Walker': [1402], 'Steel': [1404], 'Jacobsen': [1406, 1639, 1719], 'R.B.': [1407, 1640, 1720], 'Lirazan': [1408], 'M.B.': [1409], 'Hooper': [1412], 'Shetty': [1414], 'R.': [1415, 3725], 'DelaCruz': [1416], 'R.C.': [1417], 'Nielsen': [1418], 'Zhou': [1420], 'Bandyopadhyay': [1422], '274:': [1432], '30664-30671Abstract': [1433], '(125)': [1441], 'Briefly,': [1444], 'first': [1446, 2298, 2500], 'disulfide': [1447, 1497, 2263, 2286, 2316, 2347, 3067], 'bridge': [1448, 1498, 2317, 2348], 'closed': [1450, 2350], 'dripping': [1452], 'into': [1455, 1513, 1569, 2563], 'equal': [1457, 1515], 'volume': [1458, 1516], '20': [1460], 'mmpotassium': [1461], 'ferricyanide,': [1462], '0.1': [1463, 1660], 'm': [1464], 'Tris,': [1465], 'pH': [1466, 1626], '7.5.': [1467], 'solution': [1469, 1818, 2626], 'allowed': [1471, 1528], 'react': [1473, 1530], '30': [1475], 'min,': [1476], 'monocyclic': [1479, 1506, 2328], 'reverse': [1484, 2391], 'phase': [1485, 2249, 2392], 'HPLC.': [1486, 1556, 2361], 'Simultaneous': [1487], 'removal': [1488], 'theS-acetamidomethyl': [1490], 'groups': [1491, 2280, 2293], 'closure': [1493], 'carried': [1500, 3057], 'out': [1501, 3058], 'iodine': [1503, 1518, 2352], 'oxidation.': [1504, 2353], 'HPLC': [1509, 2393], 'eluent': [1510], 'dripped': [1512], '(10': [1519], 'mm)': [1520], 'H2O:trifluoroacetic': [1522], 'acid:acetonitrile': [1523], '(78:2:20': [1524], 'volume)': [1526], '10': [1532, 1798, 2719, 2895], 'min.': [1533, 1775, 2896], 'reaction': [1535, 2305], 'terminated': [1537], 'addition': [1540, 3858], 'ascorbic': [1542], 'diluted': [1544], '20-fold': [1545], '0.1%': [1547], 'trifluoroacetic': [1548], 'acid,': [1549], 'bicyclic': [1552, 2355], 'Clones': [1557], 'subunits': [1561], 'cRNA': [1566], 'injection': [1568], 'oocytes': [1571, 1740, 2893, 3237, 3637], '(15McIntosh': [1575], 'Gardner': [1577], 'Luo': [1579, 3439, 3826], 'Garrett': [1581], 'Yoshikami': [1583, 1641, 1721, 3435, 3822, 3979], 'Eur.': [1585], 'Pharmacol.': [1587, 2551, 3668, 3777, 3983], '393:': [1589], '205-208Crossref': [1590], '(43)': [1593], '30-μl': [1597], 'cylindrical': [1598], 'oocyte': [1599, 2898], 'recording': [1600, 2441, 2454], 'chamber': [1601, 2442, 2455], 'fabricated': [1602], 'Sylgard': [1604], 'gravity-perfused': [1606], 'ND96A': [1608, 1822], '(96.0': [1609], 'mm': [1610, 1613, 1618, 1624, 1963, 2038], 'NaCl,': [1611], 'KCl,': [1614], '1.8': [1615], 'mmCaCl2,': [1616], '1.0': [1617], 'MgCl2,': [1619], '1': [1620, 1765, 1933, 2825], 'μm': [1621, 1799, 3259], 'atropine,': [1622], '5': [1623, 1959, 2646, 2653], 'HEPES,': [1625], '7.1–7.5)': [1627], 'rate': [1630], '∼2/min': [1632], '(16Luo': [1633, 1713], 'Kulak': [1635, 1715], 'Cartier': [1637, 1717], 'G.E.': [1638, 1718, 3434, 3821], 'McIntosh': [1645, 1725, 2548, 3443, 3774, 3830, 3975], 'Neurosci.': [1648, 1728, 3655, 3711], '1998;': [1649, 1729, 3018, 3669], '18:': [1650, 1730], '8571-8579Crossref': [1651, 1731], 'All': [1655, 1844], 'solutions': [1657], 'contained': [1659], 'mg/ml': [1661], 'bovine': [1662], 'serum': [1663], 'albumin': [1664], 'reduce': [1666], 'nonspecific': [1667], 'adsorption': [1668], 'peptide.': [1670], 'perfusion': [1672, 1756, 1817, 2490], 'medium': [1673], 'could': [1674, 3103], 'be': [1675, 3702], 'switched': [1676, 1759, 1820], 'containing': [1679, 1762, 2627], 'ACh': [1682, 1751, 1763, 1796, 1840, 1845, 2910], 'utilizing': [1684], 'series': [1686], 'three-way': [1688], 'solenoid': [1689], 'valves.': [1690], 'ACh-gated': [1691], 'currents': [1692], 'obtained': [1694, 1788, 2671, 2916], 'two-electrode': [1697], 'voltage': [1698], 'clamp': [1699], 'amplifier': [1700], '(model': [1701], 'OC-725B,': [1702], 'Warner': [1703], 'Instrument,': [1704], 'Hamden,': [1705], 'CT)': [1706], 'data': [1708, 1906], 'captured': [1709], 'membrane': [1736], 'potential': [1737], 'clamped': [1742], '−70': [1744], 'mV.': [1745], 'To': [1746, 2688], 'apply': [1747], 'pulse': [1749], 'oocytes,': [1754], 'fluid': [1757], 's.': [1766], 'done': [1769], 'automatically': [1770], 'intervals': [1772], '1–5': [1774], 'shortest': [1777], 'time': [1778, 1865, 2053], 'interval': [1779], 'chosen': [1781], 'reproducible': [1784], 'control': [1785, 1879, 2880], 'responses': [1786, 1811, 1870, 1880, 2881, 2908], 'observable': [1791, 2662], 'desensitization.': [1792], 'concentration': [1794], 'trials': [1801], 'α1β1δε': [1803], '50': [1805, 2034, 2623], 'μmfor': [1806], 'For': [1810], '(test': [1814], 'responses),': [1815], 'toxin.': [1824, 2043, 2463, 3159], 'Toxin': [1825], 'perfused': [1827, 2902], 'until': [1828], 'maximum': [1830], 'obtained.': [1833, 2912], 'Thereafter,': [1834], 'washed': [1837, 1860], 'away': [1838, 1861], 'pulses': [1841, 1846], 'given.': [1843], 'contain': [1847], 'toxin,': [1849], 'assumed': [1853, 2260], 'little': [1855, 2680], 'if': [1856, 2681], 'bound': [1858], 'brief': [1864], '(<2': [1866], 's': [1867, 2571], 'peak).': [1872], 'average': [1874, 1914], 'peak': [1875], 'amplitude': [1876, 1892], 'three': [1878, 1923, 3144], 'just': [1881], 'exposure': [1884], 'normalize': [1890], 'each': [1894, 3905], 'test': [1895], 'response': [1896, 2729, 3970, 4009], 'obtain': [1898], '"%': [1900, 1903], 'response"': [1901], 'block."': [1904], 'Each': [1905], 'point': [1907], 'dose-response': [1910], 'curve': [1911], 'represents': [1912], 'value': [1915], '±': [1916, 2724], 'S.E.': [1917], 'measurements': [1919], 'least': [1922], 'Dose-response': [1925], 'curves': [1926], 'equation': [1931], '%response=100/{1+([toxin]/IC50)nH}Equation': [1932], 'where': [1934, 2236, 3963], 'nH': [1935], 'Hill': [1938], 'coefficient,': [1939], 'Prism': [1941], 'software': [1942], '(GraphPad': [1943], 'Software,': [1944], 'San': [1945], 'Diego)': [1946], 'Apple': [1949], 'Power': [1950], 'Macintosh.': [1951], 'Goldfish': [1952], '(4–5': [1953], 'cm)': [1954], 'injected': [1956, 2031, 2561, 2620], 'intramuscularly': [1957, 2562], '150': [1962, 2037], 'NaCl': [1964, 2039], 'without': [1967, 2042, 2905], 'Hamilton': [1971], 'syringe.': [1972], 'Fish': [1973], 'observed': [1975, 2046], 'placing': [1979], 'them': [1980], '500-ml': [1983], 'beaker': [1984, 2008], 'water': [1986, 1990], 'stirring': [1988], 'glass': [1993], 'rod': [1994], '∼120': [1996], 'revolutions/min.': [1997], 'Unaffected': [1998], 'able': [2001], 'maintain': [2003], 'position': [2005], 'swimming': [2010], 'current.': [2013, 2024, 2716], 'As': [2014, 2809], 'became': [2016], 'progressively': [2017], 'paralyzed,': [2018], 'increasingly': [2020], 'drifted': [2021], 'Young': [2025], 'Swiss-Webster': [2026, 2610], 'mice': [2027, 2611, 2618], '(∼12': [2028], 'g)': [2029], 'intraperitoneally': [2032, 2621], 'Mice': [2044], 'symptoms': [2048], 'paralysis,': [2050], 'monitoring': [2057], 'heartbeat': [2058], 'stethoscope.': [2061], 'Mature': [2062], 'derived': [2065], 'proteolytic': [2067], 'processing': [2068, 2103], 'larger': [2070], 'precursor': [2071, 2124], 'proteins.': [2072], 'case': [2075, 2944], 'α-conotoxins,': [2078, 2274], 'prepropeptide': [2080, 2220], '∼60': [2082], 'amino': [2083, 2092, 2114, 3147, 3376, 3386], 'acids,': [2084, 3377], '13–18': [2091], 'acids': [2093, 2115, 3148, 3387], 'located': [2094], 'C': [2097], 'terminus': [2098], 'precursor.': [2101], 'site': [2104], 'usually': [2105], 'consists': [2106], 'pair': [2111], 'basic': [2113], 'immediately': [2117], 'precedes': [2118], 'We': [2143, 2958, 3077, 3415, 3848], 'exploited': [2144], 'conserved': [2146], 'features': [2147], 'gene': [2151, 2168, 2185, 2974], 'structure': [2152], 'isolate': [2154], 'gene.': [2158], 'primers': [2160], 'designed': [2162], 'directly': [2164], 'amplify': [2165], 'DNA.': [2172], 'fromC.': [2178], 'yielded': [2180], 'single': [2182], 'specific': [2183], 'α-conopeptide': [2184], 'product,': [2186], 'cloned': [2189], 'sequenced.': [2191], 'Three': [2192], 'identical': [2193, 2459], 'representing': [2195], 'identified.': [2201], 'MII': [2206, 2835, 3367, 3398, 3426, 3471, 3542], 'magus': [2209, 3740, 3805], 'shown': [2211, 2755, 2810, 3184], 'comparison': [2213], '(see': [2214, 2406, 2737, 3124], 'Fig.': [2215, 2738, 2812, 3495], '1).': [2216], 'Note': [2217], 'regions': [2221, 2235], 'two': [2224, 2918, 3155, 3356, 3413, 3916], 'highly': [2227, 3745], 'conserved,': [2228], 'there': [2237, 3093, 3141], 'considerable': [2239], 'divergence': [2240], 'C-terminal': [2243, 3271, 3280, 3385], 'portion': [2244], 'peptides.': [2247], 'Solid': [2248], 'undertaken.': [2257], 'bridging': [2264], 'analogous': [2269], 'is,': [2276], 'Cys1–Cys3,': [2277], 'Cys2–Cys4.': [2278], 'orthogonally': [2282], 'direct': [2285, 3066], 'formation': [2287, 3069], 'configuration.': [2290], 'Acid-labile': [2291], 'protecting': [2292], 'third': [2300], 'cysteines': [2301], 'during': [2302], 'cleavage': [2304], 'released': [2307], 'linear': [2308], 'resin.': [2312], 'Closure': [2313], 'accomplished': [2319], 'use': [2321], 'FeCN.': [2323], 'After': [2324, 2879], 'HPLC,': [2331], 'acid-stabile': [2333], 'acetamidomethyl': [2334], 'group': [2335], 'next': [2337], 'fourth': [2343], 'cysteines,': [2344], 'again': [2359], 'Liquid': [2362], 'secondary': [2363], 'ionization': [2364], 'mass': [2365], 'spectrometry': [2366], 'consistent': [2372, 3239, 3646], 'amidated': [2375], '(monisotopic': [2377], 'MH+:': [2378], 'calculated,': [2379], '1609.6;': [2380], 'observed,': [2381], '1609.5).': [2382], 'considerably': [2387], 'earlier': [2388], 'column': [2394], 'compared': [2395], 'another': [2403], 'fish-hunting': [2404, 3121], 'Fig.2).': [2407], 'greater': [2409], 'hydrophilicity': [2410], 'seemed': [2413], 'practical': [2416], 'consequences': [2417], 'handling.': [2420], 'did': [2423, 2434, 2590, 2658], 'not': [2424, 2435, 2591, 2659, 3083, 3590, 3883, 3930], 'fully': [2425], 'investigate': [2426], 'phenomenon,': [2428], 'appeared': [2430], 'significantly': [2436, 3694], 'stick': [2437], 'electrophysiological': [2440, 3505], 'does': [2444, 3565], 'MII.': [2446, 2933], 'Therefore,': [2447], 'bath': [2448, 2476], 'applications': [2449], 'gave': [2456], 'similar': [2457, 2783, 3332, 3347, 3601], 'perfusion-applied': [2462], 'hydrophobic': [2471], 'application': [2477, 2491, 2928], 'can': [2480], 'lead': [2481], '5–10-fold': [2484], 'underestimation': [2485], 'potency': [2487, 2792, 3510], '(compared': [2488], 'toxin).': [2493], 'feeds': [2496], 'entrapping': [2501], 'its': [2502, 3324, 3574, 3860], 'distensible': [2506], 'stomach': [2507], 'then': [2509, 2900], 'harpooning': [2510], 'envenomating': [2512], 'produces': [2517, 3622, 3741, 3807], 'both': [2518, 2789, 3350], 'GI': [2520, 2528, 2560, 2630, 2638], 'newly': [2523, 3031, 3161], 'GIC.': [2526, 2633, 4024], '(17Johnson': [2540, 3766], 'D.S.': [2541, 3767], 'Martinez': [2542, 3768], 'Elgoyhen': [2544, 3770], 'A.B.': [2545, 3771], 'Heinemann': [2546, 3722, 3772], 'S.F.': [2547, 3723, 3773, 3972], 'Mol.': [2550, 3667, 3776], '48:': [2553, 3779], '194-199PubMed': [2554, 3780], 'nmol': [2558, 2586, 2635, 2654], 'produced': [2565, 2710, 3253], 'signs': [2566, 2594], 'less,': [2573], 'full': [2575], '3': [2578, 3303], 'min': [2579, 2647], '(n': [2580, 2597, 2648, 2667, 2734], '=': [2581, 2598, 2649, 2668, 2735], '3).': [2582, 2599, 2669, 2739], '3.5': [2585], 'effects': [2601], 'these': [2603, 2804, 3886], 'assessed': [2607], 'young': [2609], 'under': [2614], '"Experimental': [2615], 'Procedures."': [2616], '25-day-old': [2617], 'either': [2628, 3218], 'Two': [2634], 'caused': [2639], '2).': [2650, 3400], 'motor': [2663], 'deficits': [2664], 'Results': [2670], 'bioassays': [2674], 'indicated': [2675], 'had': [2679], 'nAChR.': [2687], 'examine': [2689], 'further,': [2691], '(α1β1δε)': [2701], 'inXenopus': [2702], 'Exposure': [2704], 'μmtoxin': [2709], 'ACh-induced': [2715, 2728, 3250], 'nm': [2720, 2885, 2931, 3301], 'blocked': [2722, 3681], '91.5': [2723], '2.4%': [2725], '6)': [2736], 'Concentration-response': [2740], 'analysis': [2741], 'conducted': [2743], 'combinations': [2749], 'Fig.4': [2757], 'TableI.': [2759], '>5': [2764], 'orders-of-magnitude': [2765], 'selectivity': [2766, 3523, 3557], 'combinationversus': [2771], 'pharmacological': [2776, 3325, 3602], 'profile': [2777, 3326], 'generally': [2782], 'MII;': [2788], 'combination.': [2797], 'However,': [2798, 3803], '5,': [2813], 'reversed': [2819, 3492], 'relatively': [2820, 3757], 'rapidly': [2821, 2877, 3491], '(>50%': [2822], 'recovery': [2823, 2842, 2935], 'min)': [2826], 'upon': [2827], 'washout.': [2829], 'only': [2837, 3428, 3812, 3931], 'slowly': [2838, 3429], 'reversed,': [2839], '∼50%': [2841], 'after': [2843], '19': [2844], 'min.Table': [2845], 'IIC50s': [2846], 'oocytesnAChRIC50nmhα1β1δɛ>100,000hα3β21.1hα3β4755hα4β2309h,': [2855], 'human.': [2856, 2957], 'Open': [2857, 3273], 'table': [2858, 3274], 'tab': [2862, 3278], 'Figure': [2863, 2950], '5Wash-out': [2864], 'MII.A,': [2870], 'reversible.': [2878], 'obtained,': [2883], 'applied': [2889], 'α3β2-expressing': [2892], 'continuously': [2901], 'buffer': [2904], 'while': [2907], 'Similar': [2913], 'experiments.': [2920], 'B,': [2921], 'same': [2923], '∼20-fold': [2939], 'slower': [2940, 3474], 'GIC.View': [2947], 'Large': [2948], 'Image': [2949], 'ViewerDownload': [2951], 'Hi-res': [2952], 'image': [2953], 'Download': [2954], '(PPT)': [2955], 'h,': [2956], 'conotoxin': [2964, 2977, 3197], 'four': [2966], 'homology': [2970], 'encoding': [2973], 'genes': [2978], 'reveals': [2979], 'belongs': [2983], 'A-superfamily': [2986, 2990], 'ofConus': [2987], 'toxins.': [2988, 3414], 'peptides,': [2995], 'nAChRs,': [3001], 'although': [3002], 'others': [3003], 'potassium': [3006], 'sodium': [3008], 'channels': [3009], '(18McIntosh': [3010], 'Methods': [3016], 'Enzymol.': [3017], '294:': [3019], '605-624Crossref': [3020], '(77)': [3022], 'relegates': [3034], 'family,': [3039], 'members': [3040], 'total': [3047], 'chemical': [3048], 'peptide,': [3053], 'orthogonal': [3060], 'α-conotoxins.': [3076], 'note': [3078], 'yet': [3084, 3904], 'venom.': [3088], 'possible': [3091], 'post-translational': [3095], 'modifications': [3096], 'present': [3097, 3587], 'native': [3100], 'influence': [3104], 'properties': [3106], 'reported': [3107, 3604], 'report.': [3115], 'Previously': [3116], 'speciesC.': [3122], 'Table': [3125, 3305], 'II)': [3126], 'what': [3128], 'referred': [3130], 'literature': [3134], '3/5': [3137], 'spacing,': [3138], 'indicating': [3139], 'respectively': [3143], 'five': [3146], 'between': [3150, 3411], 'loops': [3156], '4/7': [3166], 'spacing.': [3167, 3354], 'α3/5': [3169, 3196], 'based': [3172], 'ability': [3175], 'cause': [3177], 'mice,': [3180], 'inhibit': [3187], 'Likewise,': [3193], 'geographus,': [3200, 3567], 'GI,': [3202], 'fails': [3213], 'mouse': [3219], 'Electrophysiological': [3222], 'testing': [3223], 'lack': [3241, 3873], 'activity.': [3244, 4015], 'Little': [3245], 'current': [3251], 'toxin.Table': [3260], 'IIα-Conotoxinsα-ConotoxinSpeciesSequencenAChR': [3261], 'targetGICC.': [3262], 'geographusGCCSHPACAGNNQHIC#NeuronalMIIC.': [3263], 'magusGCCSNPVCHLEHSNLC#NeuronalGIC.': [3264], 'geographusECCNPACGRHYSC#MuscleGIAC.': [3265], 'geographusECCNPACGRHYSCGK#MuscleGIBC.': [3266], 'geographusECCNPACGRHYSCKG#MuscleMIC.': [3267], 'magusGRCCHPACGKNYSC#MuscleMIAC.': [3268], 'magusDGRCCHPACAKHFNC#MuscleMIBC.': [3269], 'magusNGRCCHPACARKYNC#Muscle#,': [3270], 'amidation.': [3272, 3281], '#,': [3279], 'On': [3282], 'hand,': [3285], 'blocks': [3289, 3631], 'combination': [3293], 'IC50': [3298], '∼1': [3300, 3639], '(Fig.': [3302, 3399], 'I).': [3306], 'modest': [3311], 'amount': [3312], 'α3β4': [3316], 'α4β2': [3318], 'subtypes.': [3320], 'With': [3321], 'respect': [3322], 'activity,': [3328], 'receptors,': [3343], 'structurally': [3346], 'α4/7': [3353], 'differ': [3358, 3379], 'number': [3361], 'respects,': [3363], 'however.': [3364], 'share': [3370], 'six': [3371], 'eight': [3374, 3384], 'N-terminal': [3375], 'seven': [3381], '(Table': [3388], 'II).': [3389], 'hydrophilic': [3395], 'Particularly': [3401], 'difference': [3405], 'demonstrated': [3417], 'rat': [3421], 'receptors': [3423, 3478, 3633, 3678, 3958, 4004], 'reversible': [3430], '(t12∼7.7': [3431], 'min;': [3432], '(19Cartier': [3433, 3820], '1996;': [3448, 3656, 3712, 3835], '271:': [3449, 3836], '7522-7528Abstract': [3450, 3837], '(451)': [3458, 3845], 'demonstrate': [3465], 'off-time': [3468], '(t12': [3479], '∼19': [3480], 'min).': [3481], '(∼20-fold': [3493], 'faster;': [3494], '5),': [3496], 'potentially': [3501], 'useful': [3502], 'ligand': [3503, 3536], 'experiments,': [3506], 'reversibility': [3513], 'desired': [3515], 'characteristics.': [3516], 'highest': [3521], '(e.g.': [3526, 3763], 'subtype)': [3529], 'versus': [3530, 3560], 'itself': [3543], 'already': [3545], 'quite': [3546], '(>1,000-fold': [3548], 'selectivityversus': [3549], 'subtype),': [3552], '>100,000-fold': [3556], 'receptor.': [3563, 3879], 'Why': [3564], 'mollusc': [3569], 'depends': [3571], 'paralyzing': [3573], 'nonparalytic': [3578], 'receptors?': [3585], 'findings': [3588], 'do': [3589], 'answer': [3591], 'question,': [3593], 'worth': [3597], 'noting': [3598], 'compounds': [3599], 'specificity': [3603], 'organisms.': [3608], 'Bungarus': [3614], 'multicinctus': [3615], 'α-bungarotoxin,': [3618], 'minor': [3624], 'κ-bungarotoxin,': [3628, 3683, 3888], 'nm).': [3640], 'mechanism': [3642], 'action': [3644], 'competitive': [3648], 'blockade': [3649], '(20Harvey': [3650, 3706], 'S.C.': [3651, 3666, 3707], 'Luetje': [3652, 3708], 'C.W.': [3653, 3662, 3709], '16:': [3657, 3713], '3798-3806Crossref': [3658, 3714], 'Scholar,21Luetje': [3661], 'Maddox': [3663], 'F.N.': [3664], '1112-1119PubMed': [3671], 'Additional': [3674], 'subtypes': [3675], 'including': [3684], 'block,': [3691], 'however,': [3692, 3956], 'different,': [3695], 'α3β2-like': [3698, 3910, 3943, 3957, 4003], 'seems': [3700, 3913], 'target': [3705, 3934, 3942, 4002], '22Papke': [3718], 'R.L.': [3719], 'Duvoisin': [3720], 'R.M.': [3721], 'Proc.': [3724], 'Soc.': [3726], 'Lond.': [3727], 'B': [3728], 'Sci.': [3730], '1993;': [3731], '252:': [3732], '141-148Crossref': [3733], '(45)': [3736], 'inactive': [3758], 'MI)': [3765], 'Scholar,23McIntosh': [3782], 'Hunkapiller': [3786], 'M.W.': [3787], 'Biophys.': [3794], '1982;': [3795], '218:': [3796], '329-334Crossref': [3797], '(158)': [3800], 'very': [3813, 3917], 'weak': [3814, 3895], 'establish': [3849], 'report': [3852], 'produces,': [3856], 'muscle-targeted': [3861], 'Perhaps': [3880], 'coincidental': [3884], 'polypeptides,': [3887], 'receptors.': [3911, 3944], 'distinct': [3918], '(snakes': [3922], 'snails)': [3924], 'appear': [3925], 'independently': [3928], 'evolved': [3929], 'those': [3939], 'specifically': [3941], 'utility': [3947], 'latter': [3950], 'type': [3951], 'unknown;': [3955], 'exist': [3959], 'autonomic': [3961], 'ganglia,': [3962], 'part': [3966], 'modulate': [3967], '(24Tavazoie': [3971], 'Tavazoie': [3973], 'M.F.': [3974], 'Br.': [3981], '120:': [3985], '995-1000Crossref': [3986], '(20)': [3989], 'possibility': [3993], 'function': [3997], 'suppress': [4007], 'rather': [4010], 'Alexandria': [4016], 'Vyazovkina': [4017], 'assisted': [4018]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2103229353', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-07T14:47:59.163678', 'created_date': '2016-06-24'}