Publication Information

{'id': 'https://openalex.org/W2103017729', 'doi': 'https://doi.org/10.1128/aac.48.4.1281-1288.2004', 'title': '<i>Mycobacterium tuberculosis</i> DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug Activity', 'display_name': '<i>Mycobacterium tuberculosis</i> DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug Activity', 'publication_year': 2004, 'publication_date': '2004-03-26', 'ids': {'openalex': 'https://openalex.org/W2103017729', 'doi': 'https://doi.org/10.1128/aac.48.4.1281-1288.2004', 'mag': '2103017729', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15047530', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/375300'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.48.4.1281-1288.2004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc375300?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090449409', 'display_name': 'Alexandra Aubry', 'orcid': 'https://orcid.org/0000-0003-4230-4793'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Alexandra Aubry', 'raw_affiliation_strings': ['Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, and Laboratoire de Recherche Moléculaire sur les Antibiotiques, INSERM 0004, Université Pierre et Marie Curie, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, and Laboratoire de Recherche Moléculaire sur les Antibiotiques, INSERM 0004, Université Pierre et Marie Curie, Paris, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110436610', 'display_name': 'Xiao-Su Pan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1310053265', 'display_name': "St George's Hospital", 'ror': 'https://ror.org/0001ke483', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1310053265', 'https://openalex.org/I2801196673']}, {'id': 'https://openalex.org/I124357947', 'display_name': 'University of London', 'ror': 'https://ror.org/04cw6st05', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947']}, {'id': 'https://openalex.org/I165862685', 'display_name': "St George's, University of London", 'ror': 'https://ror.org/040f08y74', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I165862685', 'https://openalex.org/I4401726869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Su Pan', 'raw_affiliation_strings': ["Molecular Genetics Group, Department of Biochemistry and Immunology, St. George's Hospital Medical School, University of London, London SW17 ORE, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Molecular Genetics Group, Department of Biochemistry and Immunology, St. George's Hospital Medical School, University of London, London SW17 ORE, United Kingdom", 'institution_ids': ['https://openalex.org/I1310053265', 'https://openalex.org/I124357947', 'https://openalex.org/I165862685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009035925', 'display_name': 'L. Mark Fisher', 'orcid': 'https://orcid.org/0000-0002-2172-3369'}, 'institutions': [{'id': 'https://openalex.org/I1310053265', 'display_name': "St George's Hospital", 'ror': 'https://ror.org/0001ke483', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1310053265', 'https://openalex.org/I2801196673']}, {'id': 'https://openalex.org/I165862685', 'display_name': "St George's, University of London", 'ror': 'https://ror.org/040f08y74', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I165862685', 'https://openalex.org/I4401726869']}, {'id': 'https://openalex.org/I124357947', 'display_name': 'University of London', 'ror': 'https://ror.org/04cw6st05', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'L. Mark Fisher', 'raw_affiliation_strings': ["Molecular Genetics Group, Department of Biochemistry and Immunology, St. George's Hospital Medical School, University of London, London SW17 ORE, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Molecular Genetics Group, Department of Biochemistry and Immunology, St. George's Hospital Medical School, University of London, London SW17 ORE, United Kingdom", 'institution_ids': ['https://openalex.org/I1310053265', 'https://openalex.org/I165862685', 'https://openalex.org/I124357947']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055642273', 'display_name': 'Vincent Jarlier', 'orcid': 'https://orcid.org/0000-0003-0957-0002'}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Vincent Jarlier', 'raw_affiliation_strings': ['Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, and Laboratoire de Recherche Moléculaire sur les Antibiotiques, INSERM 0004, Université Pierre et Marie Curie, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, and Laboratoire de Recherche Moléculaire sur les Antibiotiques, INSERM 0004, Université Pierre et Marie Curie, Paris, France', 'institution_ids': ['https://openalex.org/I39804081', 'https://openalex.org/I154526488']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108222588', 'display_name': 'Emmanuelle Cambau', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Emmanuelle Cambau', 'raw_affiliation_strings': ['Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, and Laboratoire de Recherche Moléculaire sur les Antibiotiques, INSERM 0004, Université Pierre et Marie Curie, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, and Laboratoire de Recherche Moléculaire sur les Antibiotiques, INSERM 0004, Université Pierre et Marie Curie, Paris, France', 'institution_ids': ['https://openalex.org/I39804081', 'https://openalex.org/I154526488']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.327, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 221, 'citation_normalized_percentile': {'value': 0.932763, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '48', 'issue': '4', 'first_page': '1281', 'last_page': '1288'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sparfloxacin', 'display_name': 'Sparfloxacin', 'score': 0.70557207}, {'id': 'https://openalex.org/keywords/gatifloxacin', 'display_name': 'Gatifloxacin', 'score': 0.69907206}, {'id': 'https://openalex.org/keywords/quinolone', 'display_name': 'Quinolone', 'score': 0.54545027}], 'concepts': [{'id': 'https://openalex.org/C167125095', 'wikidata': 'https://www.wikidata.org/wiki/Q70551687', 'display_name': 'DNA gyrase', 'level': 4, 'score': 0.95475626}, {'id': 'https://openalex.org/C158456008', 'wikidata': 'https://www.wikidata.org/wiki/Q412639', 'display_name': 'DNA supercoil', 'level': 4, 'score': 0.7717283}, {'id': 'https://openalex.org/C2775876089', 'wikidata': 'https://www.wikidata.org/wiki/Q281082', 'display_name': 'Nalidixic acid', 'level': 4, 'score': 0.74085474}, {'id': 'https://openalex.org/C2780926990', 'wikidata': 'https://www.wikidata.org/wiki/Q976559', 'display_name': 'Sparfloxacin', 'level': 5, 'score': 0.70557207}, {'id': 'https://openalex.org/C2777653605', 'wikidata': 'https://www.wikidata.org/wiki/Q2365016', 'display_name': 'Gatifloxacin', 'level': 4, 'score': 0.69907206}, {'id': 'https://openalex.org/C2779922871', 'wikidata': 'https://www.wikidata.org/wiki/Q426549', 'display_name': 'Quinolone', 'level': 3, 'score': 0.54545027}, {'id': 'https://openalex.org/C22744801', 'wikidata': 'https://www.wikidata.org/wiki/Q172778', 'display_name': 'Plasmid', 'level': 3, 'score': 0.5198648}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.5168177}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.49061027}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.45524}, {'id': 'https://openalex.org/C3019249092', 'wikidata': 'https://www.wikidata.org/wiki/Q274493', 'display_name': 'Antibacterial agent', 'level': 3, 'score': 0.44063944}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.35309702}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3288135}, {'id': 'https://openalex.org/C2778049240', 'wikidata': 'https://www.wikidata.org/wiki/Q411447', 'display_name': 'Ofloxacin', 'level': 4, 'score': 0.28962964}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.25344017}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19470027}, {'id': 'https://openalex.org/C2778512257', 'wikidata': 'https://www.wikidata.org/wiki/Q256602', 'display_name': 'Ciprofloxacin', 'level': 3, 'score': 0.17976287}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.15699607}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.109627366}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.099640846}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.08869231}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.066456854}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004278', 'descriptor_name': 'DNA, Superhelical', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004278', 'descriptor_name': 'DNA, Superhelical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004591', 'descriptor_name': 'Electrophoresis, Polyacrylamide Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.48.4.1281-1288.2004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc375300', 'pdf_url': 'https://europepmc.org/articles/pmc375300?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC375300', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15047530', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc375300', 'pdf_url': 'https://europepmc.org/articles/pmc375300?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W131344869', 'https://openalex.org/W1486633844', 'https://openalex.org/W1493562191', 'https://openalex.org/W1499823044', 'https://openalex.org/W171313903', 'https://openalex.org/W1742005759', 'https://openalex.org/W1811040502', 'https://openalex.org/W1967490552', 'https://openalex.org/W1999917617', 'https://openalex.org/W2001243940', 'https://openalex.org/W2014144663', 'https://openalex.org/W2029834669', 'https://openalex.org/W2036221447', 'https://openalex.org/W2036317207', 'https://openalex.org/W2044434195', 'https://openalex.org/W2049423802', 'https://openalex.org/W2069398764', 'https://openalex.org/W2083461463', 'https://openalex.org/W2092791062', 'https://openalex.org/W2098663401', 'https://openalex.org/W2102022526', 'https://openalex.org/W2107176825', 'https://openalex.org/W2107640779', 'https://openalex.org/W2109729152', 'https://openalex.org/W2112722072', 'https://openalex.org/W2120563440', 'https://openalex.org/W2120683593', 'https://openalex.org/W2122969469', 'https://openalex.org/W2124376165', 'https://openalex.org/W2127427236', 'https://openalex.org/W2131422994', 'https://openalex.org/W2136510992', 'https://openalex.org/W2141382307', 'https://openalex.org/W2148131545', 'https://openalex.org/W2155365200', 'https://openalex.org/W2158023121', 'https://openalex.org/W2164175455', 'https://openalex.org/W2172238512', 'https://openalex.org/W2318229153', 'https://openalex.org/W2418210342', 'https://openalex.org/W640843662', 'https://openalex.org/W830467045'], 'related_works': ['https://openalex.org/W4251406891', 'https://openalex.org/W2810981840', 'https://openalex.org/W2783767043', 'https://openalex.org/W2740036970', 'https://openalex.org/W2392643775', 'https://openalex.org/W2172238512', 'https://openalex.org/W2138130154', 'https://openalex.org/W2116112574', 'https://openalex.org/W2035990717', 'https://openalex.org/W1576316273'], 'abstract_inverted_index': {'Genome': [0], 'studies': [1], 'suggest': [2, 222], 'that': [3, 112, 223, 251], 'DNA': [4, 66, 106, 114, 185, 225], 'gyrase': [5, 49, 67, 173], 'is': [6, 194], 'the': [7, 14, 23, 29, 34, 63, 172, 190, 198, 202, 215, 224, 253, 256, 260], 'sole': [8], 'type': [9], 'II': [10], 'topoisomerase': [11], 'and': [12, 37, 50, 69, 83, 90, 100, 125, 136, 143, 165, 168, 259], 'likely': [13], 'unique': [15], 'target': [16], 'of': [17, 26, 31, 40, 47, 53, 182, 189, 205], 'quinolones': [18, 27, 237], 'in': [19, 28, 75, 235, 268], 'Mycobacterium': [20], 'tuberculosis.': [21, 243], 'Despite': [22], 'emerging': [24], 'importance': [25], 'treatment': [30], 'mycobacterial': [32], 'disease,': [33], 'slow': [35], 'growth': [36], 'high': [38], 'pathogenicity': [39], 'M.': [41, 64, 151, 242, 270], 'tuberculosis': [42, 65, 152, 271], 'have': [43], 'precluded': [44], 'direct': [45], 'purification': [46], 'its': [48], 'detailed': [51], 'analysis': [52], 'quinolone': [54, 245], 'action.': [55], 'To': [56], 'address': [57], 'these': [58], 'issues,': [59], 'we': [60], 'separately': [61], 'overexpressed': [62], 'GyrA': [68, 89], 'GyrB': [70, 92], 'subunits': [71, 93], 'as': [72], 'His-tagged': [73], 'proteins': [74], 'Escherichia': [76], 'coli': [77], 'from': [78, 128, 154], 'pET': [79], 'plasmids': [80], 'carrying': [81], 'gyrA': [82], 'gyrB': [84], 'genes.': [85], 'The': [86, 109, 244], 'soluble': [87], '97-kDa': [88], '72-kDa': [91], 'were': [94], 'purified': [95], 'by': [96, 116], 'nickel': [97], 'chelate': [98], 'chromatography': [99], 'shown': [101], 'to': [102, 130, 138, 159, 187, 196], 'reconstitute': [103], 'an': [104], 'ATP-dependent': [105], 'supercoiling': [107, 115, 226], 'activity.': [108], 'drug': [110, 206], 'concentration': [111], 'inhibited': [113], '50%': [117, 208], '(IC(50))': [118], 'was': [119], 'measured': [120, 149, 203], 'for': [121], '22': [122], 'different': [123], 'quinolones,': [124], 'values': [126], 'ranged': [127, 153], '2': [129], '3': [131], 'microg/ml': [132, 140, 156, 161], '(sparfloxacin,': [133], 'sitafloxacin,': [134], 'clinafloxacin,': [135], 'gatifloxacin)': [137, 158], '>1,000': [139], '(pipemidic': [141], 'acid': [142, 164], 'nalidixic': [144, 166], 'acid).': [145], 'By': [146], 'comparison,': [147], 'MICs': [148, 216], 'against': [150, 241], '0.12': [155], '(for': [157], '128': [160], '(both': [162], 'pipemidic': [163], 'acid)': [167], 'correlated': [169, 211], 'well': [170, 213], 'with': [171, 214, 238], 'IC(50)s': [174], '(R(2)': [175, 217], '=': [176, 218], '0.9).': [177], 'Quinolones': [178], 'promoted': [179], 'gyrase-mediated': [180], 'cleavage': [181, 191], 'plasmid': [183, 209], 'pBR322': [184], 'due': [186], 'stabilization': [188], 'complex,': [192], 'which': [193], 'thought': [195], 'be': [197, 230], 'lethal': [199], 'lesion.': [200], 'Surprisingly,': [201], 'concentrations': [204], 'inducing': [207], 'linearization': [210], 'less': [212], '0.7).': [219], 'These': [220], 'findings': [221], 'inhibition': [227], 'assay': [228], 'may': [229], 'a': [231], 'useful': [232], 'screening': [233], 'test': [234], 'identifying': [236], 'promising': [239], 'activity': [240], 'structure-activity': [246], 'relationship': [247], 'demonstrated': [248], 'here': [249], 'shows': [250], 'C-8,': [252], 'C-7': [254], 'ring,': [255], 'C-6': [257], 'fluorine,': [258], 'N-1': [261], 'cyclopropyl': [262], 'substituents': [263], 'are': [264], 'desirable': [265], 'structural': [266], 'features': [267], 'targeting': [269], 'gyrase.': [272]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2103017729', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-10T05:54:26.232781', 'created_date': '2016-06-24'}