Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2102814666', 'doi': 'https://doi.org/10.1073/pnas.0406698102', 'title': 'Requirement of phospholipase D1 activity in H-Ras <sup>V12</sup> -induced transformation', 'display_name': 'Requirement of phospholipase D1 activity in H-Ras <sup>V12</sup> -induced transformation', 'publication_year': 2005, 'publication_date': '2005-01-24', 'ids': {'openalex': 'https://openalex.org/W2102814666', 'doi': 'https://doi.org/10.1073/pnas.0406698102', 'mag': '2102814666', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15668389', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/547811'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0406698102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.0406698102', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061227640', 'display_name': 'F. Gregory Buchanan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'F. Gregory Buchanan', 'raw_affiliation_strings': ['Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019498785', 'display_name': 'Matt McReynolds', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matt McReynolds', 'raw_affiliation_strings': ['Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232', 'institution_ids': ['https://openalex.org/I200719446', 'https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009232341', 'display_name': 'Anthony D. Couvillon', 'orcid': 'https://orcid.org/0000-0002-0969-7364'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anthony Couvillon', 'raw_affiliation_strings': ['Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232', 'institution_ids': ['https://openalex.org/I200719446', 'https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024464289', 'display_name': 'Yoonseok Kam', 'orcid': 'https://orcid.org/0000-0003-4712-9058'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yoonseok Kam', 'raw_affiliation_strings': ['Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232', 'institution_ids': ['https://openalex.org/I200719446', 'https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090395581', 'display_name': 'Vijaykumar Holla', 'orcid': 'https://orcid.org/0000-0002-2824-3202'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vijaykumar R. Holla', 'raw_affiliation_strings': ['Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090373031', 'display_name': 'Raymond N. DuBois', 'orcid': 'https://orcid.org/0000-0002-6385-7154'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raymond N. DuBois', 'raw_affiliation_strings': ['Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232', 'institution_ids': ['https://openalex.org/I200719446', 'https://openalex.org/I1344073410']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5063926336', 'display_name': 'John H. Exton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John H. Exton', 'raw_affiliation_strings': ['Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232'], 'affiliations': [{'raw_affiliation_string': 'Vanderbilt-Ingram Cancer Center, Vanderbilt University, 691 Preston Building, Nashville, TN 37232; and Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 701 Light Hall, Nashville, TN 37232', 'institution_ids': ['https://openalex.org/I200719446', 'https://openalex.org/I1344073410']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.194, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 62, 'citation_normalized_percentile': {'value': 0.810581, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '102', 'issue': '5', 'first_page': '1638', 'last_page': '1642'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phospholipase-d', 'display_name': 'Phospholipase D', 'score': 0.82297766}, {'id': 'https://openalex.org/keywords/phospholipase-a1', 'display_name': 'Phospholipase A1', 'score': 0.56339765}, {'id': 'https://openalex.org/keywords/pld2', 'display_name': 'PLD2', 'score': 0.53630674}, {'id': 'https://openalex.org/keywords/ras-signaling', 'display_name': 'Ras Signaling', 'score': 0.485045}], 'concepts': [{'id': 'https://openalex.org/C6182249', 'wikidata': 'https://www.wikidata.org/wiki/Q700007', 'display_name': 'Phospholipase D', 'level': 3, 'score': 0.82297766}, {'id': 'https://openalex.org/C2778597717', 'wikidata': 'https://www.wikidata.org/wiki/Q420248', 'display_name': 'Phospholipase C', 'level': 3, 'score': 0.6910093}, {'id': 'https://openalex.org/C12927208', 'wikidata': 'https://www.wikidata.org/wiki/Q210430', 'display_name': 'Phospholipase', 'level': 3, 'score': 0.66156554}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.6075197}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6005556}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.5941631}, {'id': 'https://openalex.org/C2780799628', 'wikidata': 'https://www.wikidata.org/wiki/Q700004', 'display_name': 'Phospholipase A1', 'level': 4, 'score': 0.56339765}, {'id': 'https://openalex.org/C2776909261', 'wikidata': 'https://www.wikidata.org/wiki/Q66000256', 'display_name': 'Phosphatidic acid', 'level': 4, 'score': 0.5475293}, {'id': 'https://openalex.org/C180373561', 'wikidata': 'https://www.wikidata.org/wiki/Q18030588', 'display_name': 'PLD2', 'level': 5, 'score': 0.53630674}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.43516487}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.28072882}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.27528763}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.23721683}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.15209654}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.12256989}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0758529}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.06207508}], 'mesh': [{'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D011905', 'descriptor_name': 'Genes, ras', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010739', 'descriptor_name': 'Phospholipase D', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010739', 'descriptor_name': 'Phospholipase D', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0406698102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc547811', 'pdf_url': 'https://europepmc.org/articles/pmc547811?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC547811', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15668389', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0406698102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1544834275', 'https://openalex.org/W1547066932', 'https://openalex.org/W1838271375', 'https://openalex.org/W1931771387', 'https://openalex.org/W1970147057', 'https://openalex.org/W1973800266', 'https://openalex.org/W1974628516', 'https://openalex.org/W1979861893', 'https://openalex.org/W1980952363', 'https://openalex.org/W1981785148', 'https://openalex.org/W1981972757', 'https://openalex.org/W1982501876', 'https://openalex.org/W1985046929', 'https://openalex.org/W1993163893', 'https://openalex.org/W1999251661', 'https://openalex.org/W2001258296', 'https://openalex.org/W2007375100', 'https://openalex.org/W2008346251', 'https://openalex.org/W2009856729', 'https://openalex.org/W2012228628', 'https://openalex.org/W2016235845', 'https://openalex.org/W2023962715', 'https://openalex.org/W2031429840', 'https://openalex.org/W2050621406', 'https://openalex.org/W2051571002', 'https://openalex.org/W2060611693', 'https://openalex.org/W2066254967', 'https://openalex.org/W2067889127', 'https://openalex.org/W2068625890', 'https://openalex.org/W2071697240', 'https://openalex.org/W2075104267', 'https://openalex.org/W2104136706', 'https://openalex.org/W2115671161', 'https://openalex.org/W2117693290', 'https://openalex.org/W2124357686', 'https://openalex.org/W2126567503', 'https://openalex.org/W214799791', 'https://openalex.org/W2154363497', 'https://openalex.org/W2159594827', 'https://openalex.org/W2159631180', 'https://openalex.org/W2172010546', 'https://openalex.org/W2404966510', 'https://openalex.org/W2419514907', 'https://openalex.org/W4211224007', 'https://openalex.org/W4230728981', 'https://openalex.org/W4245374570'], 'related_works': ['https://openalex.org/W4289528401', 'https://openalex.org/W4248395277', 'https://openalex.org/W2272683735', 'https://openalex.org/W2137940220', 'https://openalex.org/W2088125273', 'https://openalex.org/W2086157862', 'https://openalex.org/W2084231847', 'https://openalex.org/W2039682288', 'https://openalex.org/W2027286068', 'https://openalex.org/W1447066740'], 'abstract_inverted_index': {'The': [0], 'ability': [1, 54], 'of': [2, 17, 48, 55, 73, 129, 134, 155, 177], 'the': [3, 20, 45, 52, 86, 106, 127, 132, 153], 'Ras': [4, 18], 'oncogene': [5, 89, 109], 'to': [6], 'transform': [7], 'normal': [8, 77, 165], 'cells': [9, 102], 'has': [10, 28], 'been': [11], 'well': [12], 'established.': [13], 'One': [14], 'downstream': [15, 175], 'effector': [16], 'is': [19], 'lipid': [21], 'hydrolyzing': [22], 'enzyme': [23], 'phospholipase': [24, 34, 49, 63, 78, 135, 156, 170], 'D.': [25], 'Recent': [26], 'evidence': [27], 'emerged': [29], 'indicating': [30], 'a': [31, 149, 173], 'role': [32], 'for': [33], 'D': [35, 50], 'in': [36, 51, 92, 97, 114, 126, 138, 152, 158], 'cell': [37], 'proliferation,': [38], 'membrane': [39], 'trafficking,': [40], 'and': [41, 95, 141], 'migration.': [42], 'To': [43], 'study': [44], 'potential': [46], 'importance': [47], 'oncogenic': [53], 'Ras,': [56], 'we': [57, 68], 'used': [58], 'Rat-2': [59, 74, 82], 'fibroblasts': [60, 75, 83], 'with': [61, 85, 105, 163], 'reduced': [62], 'D1': [64, 79, 157, 171], 'activity': [65], '(Rat-2V25).': [66], 'Here,': [67], 'show': [69], 'that': [70], 'H-Ras': [71, 87, 107], 'transformation': [72], 'requires': [76], 'activity.': [80], 'WT': [81], 'transfected': [84, 104], 'V12': [88, 108], 'grew': [90], 'colonies': [91, 113], 'soft': [93, 115, 139], 'agar': [94, 116, 140], 'tumors': [96, 119, 160], 'nude': [98, 123], 'mice.': [99, 124], 'However,': [100], 'Rat-2V25': [101], 'when': [103, 120, 161], 'did': [110], 'not': [111], 'form': [112], 'or': [117], 'produce': [118], 'xenografted': [121], 'onto': [122], 'Interestingly,': [125], 'presence': [128], 'phosphatidic': [130], 'acid,': [131], 'product': [133], 'D,': [136], 'growth': [137], 'tumor': [142, 179], 'formation': [143], 'was': [144], 'restored.': [145], 'We': [146], 'also': [147], 'observed': [148], 'dramatic': [150], 'increase': [151], 'expression': [154], 'colorectal': [159], 'compared': [162], 'adjacent': [164], 'mucosa.': [166], 'Our': [167], 'studies': [168], 'identify': [169], 'as': [172], 'critical': [174], 'mediator': [176], 'H-Ras-induced': [178], 'formation.': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2102814666', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2024-08-15T09:20:39.134149', 'created_date': '2016-06-24'}