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[121], 'intact': [126], 'endothelium': [127], 'normally': [128], 'prevents': [129], 'platelet': [130, 153, 180, 187, 198, 212, 258, 300, 323, 438, 525, 577, 581, 765, 1068, 1374, 1669, 1918, 1921, 1970, 2366, 2681, 2945, 3378, 3418, 3591, 3757, 3917], 'activation,': [131], 'but': [132, 349, 541, 1882], 'intimal': [134], 'injury': [135, 471, 475, 1853], 'associated': [136, 2651, 3705], 'endothelial': [138, 479, 951, 1021, 2099], 'denudation': [139], 'exposes': [143], 'subendothelial': [144], 'collagen': [145, 164], 'von': [147, 171], 'Willebrand': [148, 172], 'factor,': [149, 173], 'which': [150, 374, 423, 559, 759, 763], 'support': [151], 'prompt': [152], 'adhesion': [154, 597, 1036, 1727, 1950], 'activation.': [156, 1375], 'Circulating': [157, 1907, 1992, 2257, 2772, 3410, 3675], 'platelets': [158, 346, 354, 367, 402, 534, 713, 910, 1054, 1124, 1194, 1469, 1877, 2093, 2137], 'can': [159], 'adhere': [160, 376], 'either': [161], 'directly': [162, 1451], 'or': [165, 1004, 1023, 1143, 1448, 1563, 3829], 'indirectly,': [166], 'via': [167, 393, 1102, 1823, 3346], 'binding': [169, 610, 689, 711, 908, 1065, 1122, 1165, 1343, 1412, 1971, 2072], 'glycoprotein': [176, 280, 315, 408, 441, 1218, 1670, 1746, 1846], 'Ib/IX': [177], 'complex.': [178], 'Local': [179], 'activation': [181, 213, 526, 578, 594, 930, 1045, 1253, 1611, 1919, 2367], 'promotes': [182, 929, 999], 'thrombus': [183], 'additional': [186, 1062], 'recruitment': [188], 'by': [189, 220, 305, 453, 488, 551, 555, 588, 693, 721, 812, 820, 958, 1090, 1168, 1189, 1234, 1261, 1471, 1493, 1643, 1818, 2071, 2124, 2142], 'supporting': [190], 'cell': [191, 1506, 2942, 3116], 'surface': [192, 399, 439, 529, 537, 582, 983, 1211, 1754, 1880, 1922], 'thrombin': [193], 'releasing': [196], 'potent': [197], 'agonists,': [199], 'such': [200, 269], 'adenosine': [202], '5′-diphosphate,': [203], 'serotonin,': [204], 'thromboxane': [206, 223], 'A2.': [207], 'central': [209], 'role': [210, 1013, 1111, 1529, 2988], 'syndromes': [217, 339, 680, 916], 'supported': [219, 452, 550], 'increased': [221, 343, 351, 416, 682, 936], 'platelet-derived': [222], 'prostaglandin': [225], 'metabolites': [226], 'detected': [227, 545], 'patients': [229, 335, 600, 613, 643, 676, 742, 781, 827, 857, 877, 1128, 1139, 1702, 1952, 2378, 3308], 'syndromes1': [233], 'clear': [236], 'clinical': [237, 309, 330], 'benefit': [238], 'treatment': [240], 'aspirin': [242], 'for': [243, 805, 843, 1064, 1389, 1576, 2303, 3211, 3634], 'prevention': [244, 2652, 2939], 'events.2See': [248], 'p': [249], '2166The': [250], 'importance': [251, 444], 'platelet-dependent': [253], 'has': [255, 725, 767, 1223], 'made': [256, 871], 'aggregate': [259, 1382, 2991], 'common': [261], 'therapeutic': [262, 1387, 1545], 'target': [263, 1388], 'Recently,': [268], 'therapies': [270], 'have': [271, 340], 'included': [272], 'use': [274, 1321, 1355, 1537], 'aspirin,': [276], 'thienopyridines,': [277], 'direct': [279, 1285], 'IIb/IIIa': [281, 316, 1219, 1671, 1747], 'inhibitors.': [282], 'Although': [283, 1147, 1258], 'mechanism': [285, 1063], 'action': [287], 'these': [289, 384, 791, 808, 1158, 1400, 1428], 'various': [290, 1648], 'agents': [291], 'differs,': [292], 'they': [293, 375, 1450, 1458], 'all': [294], 'inhibit': [295], 'fibrinogen-dependent': [296], 'platelet–platelet': [297], 'associations': [298], '(ie,': [299], 'aggregation).': [301], 'However,': [302], 'highlighted': [304], 'recent': [307, 455, 553, 818], 'disappointing': [308], 'results': [310, 1159], 'trials': [312, 1631], 'using': [313, 660], 'oral': [314, 1668], 'inhibitors,3': [317], 'merely': [318, 1430], 'preventing': [319], 'process': [321], 'aggregation': [324, 1696, 2369], 'always': [327], 'translate': [328], 'into': [329], 'efficacy.Recent': [331], 'data': [332], 'suggest': [333, 1243], 'that': [334, 383, 458, 561, 599, 709, 847, 875, 1267, 1307, 1366, 1491], 'only': [342], 'interactions': [344, 352, 426, 1006, 1107], 'between': [345, 353, 738, 920, 1066, 1085, 1174, 1517, 2704, 3199, 3513], '(homotypic': [347], 'aggregates)': [348, 358], 'also': [350, 517, 870, 900, 985, 1007, 1050, 1094], 'leukocytes': [356, 2070], '(heterotypic': [357], 'detectable': [359], 'circulating': [361, 378, 566, 685, 851, 905, 1268, 1875, 1973], 'blood.': [362, 1730], 'These': [363], 'aggregates': [364, 386, 447, 500, 516, 568, 633, 853, 1242, 1270, 1330, 1368, 1429, 1532, 1909, 1994, 2259, 3412], 'form': [365, 387], 'when': [366], 'are': [368, 569, 760, 1008, 1271, 1420, 1427, 1556, 1910, 1995, 3413], 'activated': [369, 401, 1819, 2092], 'undergo': [371], 'degranulation,': [372], 'after': [373, 562, 2372, 3173, 3312], 'leukocytes.': [379], 'Early': [380, 1483], 'work': [381, 1484], 'suggested': [382], 'heterotypic': [385, 1381, 1795], 'inflammatory': [389, 933, 1018, 1393, 1436, 2017, 2096, 3947], 'states.4': [390], 'Platelets': [391, 2168, 2299], 'bind': [392], 'P-selectin': [394, 407, 530, 538, 984, 1103, 1845, 1881, 2037, 3111], '(CD62P)': [395], 'expressed': [396, 1552], 'on': [397, 421, 949, 992, 1053, 1229, 1750, 2044, 2091, 2416, 2938, 3550, 3590], 'leukocyte': [405, 1695, 1758], 'receptor,': [406], 'ligand-1': [409, 1847], '(PSGL-1).5': [410], 'This': [411, 548, 1206], 'initial': [412, 1461], 'association': [413, 2266], 'leads': [414, 1031, 1496], 'expression': [417, 531, 937, 945, 988, 1212, 1755, 2040, 2068], 'CD11b/CD18': [419, 1000], '(Mac-1)': [420], 'leukocytes,6': [422], 'itself': [424], 'supports': [425, 816], 'platelets,': [428, 2426], 'perhaps': [429], 'because': [430, 532, 1160, 1193, 1210], 'bivalent': [431], 'fibrinogen': [432], 'links': [433], 'this': [434, 617, 1248, 1300, 1481, 1554], 'integrin': [435, 1759, 1784], 'its': [437, 1354, 1421], 'counterpart': [440], 'IIb/IIIa.7,8': [442], 'platelet–leukocyte': [446, 499, 632, 665, 1380, 1411, 1531, 3029], 'vascular': [449, 470, 478, 511, 1534], 'disease': [450, 2268, 2686], 'study': [456, 554, 587, 720, 811, 1089, 1260, 3319], 'demonstrating': [457], 'infusion': [460], 'recombinant': [462], 'human': [463, 1820, 1927, 1931], 'PSGL-1': [464, 702, 717], 'an': [466, 646, 1272, 1431, 1460, 1996, 2095], 'animal': [467], 'model': [468], 'reduced': [472], 'myocardial': [473, 564, 745, 778, 830, 860, 881, 1076, 1131, 1256, 1277, 1361, 1639, 1763, 1850, 1933, 2001, 2375, 3175], 'reperfusion': [474, 1852], 'preserved': [477], 'function.9In': [480], 'syndromes,': [483, 1417, 1447], 'markers': [484], 'cardiac': [486, 806], 'necrosis': [487, 963], 'themselves': [489], 'do': [490, 1449], 'provide': [492], 'information': [493, 630], 'about': [494, 631], 'disruption;': [496], 'measures': [497], 'be': [502, 519, 544, 1208, 1227, 1291, 1348, 1524], 'better': [504], 'reflection': [505, 1433], 'instability': [508], 'ongoing': [510, 1455], 'inflammation.': [514], 'Platelet–leukocyte': [515], 'more': [521, 571, 1351, 1912], 'sensitive': [522, 572, 1913], 'marker': [523, 573, 1274, 1358, 1914, 1998, 3416], 'than': [527, 579, 1137, 1353, 1920], 'degranulated': [533, 1876], 'rapidly': [535, 1878], 'lose': [536, 1879], 'vivo': [540, 576, 1871, 1917], 'continue': [542, 1883], 'circulation.10': [547], 'Michelson': [556, 1862, 1899], 'et': [557, 590, 622, 723, 814, 840, 1092, 1236, 1608, 1663, 1692, 1722, 1742, 1779, 1811, 1841, 1868, 1905, 1946, 1967, 1990, 2035, 2063, 2087, 2112], 'al,11': [558], 'demonstrates': [560], 'infarction,': [565, 1278, 1640], 'monocyte–platelet': [567, 852], 'P-selectin.': [583], 'In': [584, 771, 967, 1870], 'addition,': [585, 772], 'Ott': [589, 1940], 'al12': [591], 'neutrophil': [593], 'neutrophil–platelet': [596, 609], 'demonstrated': [598], 'angina': [603, 798, 1142], 'had': [604, 681, 744, 750, 884, 901], 'significant': [606, 727, 1316], 'increase': [607, 3166], 'compared': [611, 651, 833, 1280, 3177], 'stable': [615], 'angina.In': [616], 'issue': [618], 'Circulation,': [620], 'Sarma': [621, 722, 813, 1091, 1235, 1961], 'al13': [623, 724, 815, 1093, 1237], 'add': [624], 'growing': [627], 'body': [628], 'atherothrombosis': [635], 'They': [640, 869], 'studied': [641], '25': [642], 'admitted': [644], 'syndrome': [649, 2643], 'them': [652, 834], '27': [654], 'subjects': [655, 670, 792], 'noncardiac': [657, 672, 783, 1144], 'chest': [658, 673, 784, 1145], 'pain,': [659, 674], 'flow': [661, 1323], 'cytometry': [662], 'measure': [664], 'binding.': [666], 'Compared': [667], 'levels': [683, 903, 1289], 'platelet–monocyte': [686, 906, 1113, 1164, 1241, 1269, 1329, 1342, 1367], 'aggregates.': [687], 'Platelet–monocyte': [688], 'was': [690, 854, 1166], 'significantly': [691], 'decreased': [692, 1120], 'saturating': [694], 'concentrations': [695, 3170], 'monoclonal': [698], 'antibody': [699], 'directed': [700, 1525], 'against': [701, 1849], 'blockade': [705, 1749], 'P-selectin,': [707, 976], 'suggesting': [708, 1513], 'monocyte': [710, 995, 1070, 2262], 'occurs': [714], 'primarily': [715], 'through': [716], 'P-selectin.The': [719], 'several': [726], 'limitations,': [728, 809], 'including': [729, 961], 'small': [731], 'sample': [732, 3037], 'size': [733], 'demographic': [736], 'differences': [737, 1173], 'groups.': [740], 'who': [743, 824, 883], 'infarctions': [746], 'were': [747, 1177], 'older': [748, 3595], 'higher': [752, 774], 'prevalence': [753], 'diabetes': [755, 2383], 'mellitus,': [756], 'both': [757, 950], 'states': [761], 'enhanced': [764], 'reactivity': [766], 'been': [768, 1224], 'previously': [769], 'demonstrated.': [770], 'incidence': [775], 'previous': [777], 'infarction': [779, 831, 861, 882, 1077, 1132, 1362, 2376, 3176, 3370], 'pain': [785], 'makes': [786], 'it': [787, 1149], 'difficult': [788, 1151], 'differentiate': [790], 'from': [793, 1157, 1186, 1485, 3320, 3454, 3598], 'those': [794, 1559], 'group': [799], 'absence': [802, 1510], 'testing': [804], 'ischemia.Despite': [807], 'report': [819], 'Furman': [821, 839, 1262, 1984], 'colleagues,14': [823], 'examined': [825], '61': [826], '150': [836], 'control': [837], 'subjects.': [838], 'al': [841], 'controlled': [842], 'age': [844], 'found': [846], 'number': [849], 'greatest': [855], 'presenting': [862, 878], '4': [864], 'hours': [865], 'symptom': [867], 'onset.': [868], 'important': [873, 1304, 1352], 'finding': [874], 'normal': [886], 'creatine': [887, 1282], 'kinase': [888], 'isoenzyme': [889], 'ratio': [890], 'at': [891, 1333, 1526], 'time': [893], 'hospital': [895], 'presentation': [896], '(just': [897], 'over': [898, 3032], '50%)': [899], 'elevated': [902], 'aggregates.The': [907], 'monocytes': [912, 954, 1126, 1974, 2947], 'highlights': [917], 'interaction': [919, 1101, 1752], 'inflammation': [921, 1705, 2607], 'cardiovascular': [925, 3421], 'disease.': [926, 1615], 'Plaque': [927], 'response,': [934], 'tissue': [939, 947, 972, 990, 1040, 2042], 'factor': [940, 948, 964, 973, 991, 1041, 2043], 'initiates': [941, 3112], 'extrinsic': [942], 'coagulation.': [943], 'cells': [952, 1022, 1495, 1503, 1822, 2421], 'partially': [956], 'regulated': [957], 'proinflammatory': [959], 'cytokines,': [960], 'tumor': [962], 'interleukin-1.15': [966], 'addition': [968, 1098], 'initiating': [970], 'coagulation,': [971], 'interacts': [974], 'accelerating': [977], 'fibrin': [978], 'deposition.15': [981], 'Platelet': [982, 1610, 2114, 2562, 2731, 2816, 2978, 3110, 3205, 3250, 3944], 'induces': [986, 2038, 3371, 3916], 'monocytes,16': [993], 'enhances': [994, 2680], 'cytokine': [996, 2067, 2641, 3256], 'expression,17': [997], 'expression.6CD40–CD40': [1001], 'ligand': [1002, 2090, 2116], '(CD40L': [1003], 'CD154)': [1005], 'known': [1009], 'play': [1011, 1109], 'atherosclerotic,': [1015], 'thrombotic,': [1016], 'processes.18': [1019], 'On': [1020], 'monocytes,': [1024, 3120], 'engagement': [1026], 'CD40': [1028, 2089, 2115], 'CD40L': [1030, 1049, 1222], 'synthesis': [1034], 'molecules,': [1037], 'chemokines,': [1038], 'causes': [1043], 'matrix': [1047], 'metalloproteinases.': [1048], 'upregulated': [1052], 'fresh': [1057], 'thrombus.18': [1058], 'Thus,': [1059], 'potential': [1061, 1184, 1245, 1385], 'setting': [1073, 1443], 'CD40–CD40L,': [1080], 'representing': [1081], 'unique': [1083, 1515], 'link': [1084, 1516], 'inflammation.The': [1088], 'suggests': [1095], 'that,': [1096], 'PSGL-1,': [1105], 'cation-independent': [1106], 'interactions.': [1114, 1797], 'Incubation': [1115], 'calcium': [1118], 'chelator': [1119], 'among': [1127, 1138, 3488], 'greater': [1135], 'extent': [1136], 'pain.': [1146], 'intriguing,': [1148], 'draw': [1153], 'any': [1154], 'definitive': [1155], 'conclusions': [1156], 'most': [1161], 'inhibited': [1167], 'chelation,': [1170], 'groups': [1176], 'small.': [1178], 'External': [1179], 'chelation': [1180], 'does': [1181, 1410], 'eliminate': [1183], 'contribution': [1185], 'pathways': [1187], 'mediated': [1188], 'internal': [1190, 1230], 'Ca2+': [1191, 1231], 'stores': [1192], 'contain': [1195], '≈20': [1196], 'nmol': [1197], 'Ca2+/108': [1199], 'cells,': [1200], 'mostly': [1201], 'stored': [1202], 'dense': [1204], 'granules.': [1205], 'relevant': [1209], 'active': [1215], 'conformation': [1216], 'shown': [1225], 'dependent': [1228, 1792], 'stores.19The': [1232], 'studies': [1233, 1522, 1924], 'others11,12,14': [1239], 'utility': [1246, 1298], 'measurement': [1249, 1327], 'diagnosing': [1251], 'infarction.': [1257, 1764, 1934, 2002], 'colleagues14': [1264], 'first': [1265, 1345], 'showed': [1266, 1490], 'early': [1273, 1997], 'kinase-MB,': [1283], 'comparison': [1286], 'troponin': [1288, 1311], 'would': [1290, 1344], 'necessary': [1292], 'establish': [1294], 'true': [1296], 'diagnostic': [1297, 1540], 'measurement.': [1301], 'It': [1302], 'note': [1306], 'ease': [1309], 'measurements': [1312], 'greatly': [1313], 'exceeds': [1314], 'limitations': [1317], 'involved': [1318], 'cytometry,': [1324], 'making': [1325], 'routine': [1326], 'comparatively': [1331], 'impractical': [1332], 'present': [1335], 'time.': [1336], 'A': [1337, 2314, 2360, 2363, 2557, 3023, 3316, 3697, 3700, 3748, 3821], 'simpler': [1338], 'method': [1339], 'measuring': [1341], 'need': [1346], 'established.': [1349], 'Possibly': [1350], 'fact': [1365], 'represent': [1369, 1459], 'novel': [1371], 'index': [1372], 'Perhaps': [1376], 'equally': [1377], 'important,': [1378], 'represents': [1383], 'new': [1386], 'limiting': [1390], 'thrombotic': [1391, 1438], 'responses': [1394], 'syndromes.All': [1398], 'observations': [1401], 'lead': [1402], 'central,': [1405], 'yet': [1406], 'unanswered,': [1407], 'question:': [1408], 'Why': [1409], 'occur': [1413], 'what': [1419, 1476], 'pathobiological': [1422], 'consequences': [1423, 1546], '(if': [1424], 'any)?': [1425], 'Furthermore,': [1426], 'epiphenomenal': [1432], 'processes': [1439], 'occurring': [1440], 'contribute': [1452], 'atherothrombogenesis?': [1456], 'Do': [1457], 'step': [1462], 'phagocytotic': [1465], 'clearance': [1466], '"spent"': [1468], '(thrombophagocytosis)': [1470], 'monocytic': [1472, 1494, 1502], 'cells?': [1473], 'If': [1474], 'so,': [1475], 'consequence': [1479], 'phagocytosis?': [1482], 'one': [1486], 'us': [1488], '(J.L.)': [1489], 'thrombophagocytosis': [1492], 'cholesteryl': [1498, 2139], 'ester': [1499, 2140], 'accumulation': [1500], 'foam': [1505, 2420, 2941], 'hyperlipidemia,': [1512], 'atherogenesis.20': [1520], 'Future': [1521], 'should': [1523], 'understanding': [1527], 'disease,': [1535, 2273, 3422], 'their': [1536, 1549, 2265], 'tool,': [1541], 'possible': [1544], 'inhibiting': [1548], 'formation.The': [1550], 'opinions': [1551], 'editorial': [1555], 'necessarily': [1558], 'editors': [1562], 'American': [1566, 2275, 3520, 3640], 'Heart': [1567, 3641], 'Association.The': [1568], 'authors': [1569], 'thank': [1570], 'Stephanie': [1571], 'Tribuna': [1572], 'Jalna': [1574], 'Ross': [1575], 'expert': [1577], 'secretarial': [1578], 'assistance.FootnotesCorrespondence': [1579], 'Freedman,': [1583], 'MD,': [1584], '715': [1590], 'Albany': [1591], 'St,': [1592], 'W507,': [1593], 'MA': [1595], '02118.': [1596], 'E-mail': [1597], '[email': [1598], 'protected]': [1599], 'References': [1600], '1': [1601, 2822, 3347], 'Fitzgerald': [1602], 'DJ,': [1603], 'Roy': [1604], 'L,': [1605, 1741, 2194, 2502, 2834, 3536, 3574, 3663], 'Catella': [1606], 'F,': [1607, 2196, 2500, 2530, 3101, 3136, 3237, 3616, 3889, 3897], 'al.': [1609, 1664, 1693, 1723, 1743, 1780, 1812, 1842, 1869, 1906, 1947, 1968, 1991, 2036, 2064, 2088, 2113], 'N': [1616, 2929, 3296, 3580, 3723], 'Engl': [1617], 'J': [1618, 1765, 1798, 2003, 2021, 2145, 2674, 3158, 3248, 3405, 3408, 3855, 3858, 3909, 3912], 'Med.': [1619], '1986;': [1620], '315:': [1621], '983–989.CrossrefMedlineGoogle': [1622], 'Scholar2': [1623], 'Antiplatelet': [1624], 'Trialists': [1625], 'Collaboration.': [1626], 'Collaborative': [1627], 'overview': [1628], 'randomised': [1630], 'antiplatelet': [1633, 1645], 'therapy:': [1634], 'I:': [1635], 'Prevention': [1636], 'death,': [1638], 'stroke': [1642, 2613], 'prolonged': [1644], 'therapy': [1646, 2649, 3300], 'categories': [1649], 'patients.': [1651], 'BMJ.': [1652], '1994;': [1653, 2053], '308:': [1654], '81–106.CrossrefMedlineGoogle': [1655], 'Scholar3': [1656], 'Chew': [1657], 'DP,': [1658], 'Bhatt': [1659], 'DL,': [1660], 'Sapp': [1661], 'S,': [1662, 1689, 1966, 2200, 2238, 2244, 2248, 2354, 2626, 2628, 2747, 2757, 2765, 2866, 3438, 3468, 3470, 3782, 3784, 3851, 3893, 3895], 'Increased': [1665, 1948, 1969], 'mortality': [1666, 3306], 'antagonists:': [1672], 'meta-analysis': [1674], 'phase': [1676], 'III': [1677], 'multicenter': [1678], 'randomized': [1679, 3600], 'trials.': [1680], 'Circulation.': [1681, 1935, 1956, 1979, 2076], '2001;': [1682, 1936, 2007, 2127], '103:': [1683], '201–206.CrossrefMedlineGoogle': [1684], 'Scholar4': [1685], 'Arber': [1686], 'N,': [1687, 2060, 2344, 2402, 3014, 3085, 3393, 3534], 'Berliner': [1688], 'Pras': [1690], 'E,': [1691, 2192, 2291, 3093, 3152, 3572, 3620, 3651, 3655], 'Heterotypic': [1694], 'peripheral': [1699, 2886], 'blood': [1700, 3119], 'leukemia,': [1704], 'stress.': [1707], 'Nouv': [1708], 'Rev': [1709], 'Fr': [1710], 'Hematol.': [1711], '1991;': [1712, 1732, 1801], '33:': [1713], '251–255.MedlineGoogle': [1714], 'Scholar5': [1715], 'Rinder': [1716, 1720], 'HM,': [1717], 'Bonan': [1718], 'JL,': [1719], 'CS,': [1721], 'Dynamics': [1724], 'leukocyte-platelet': [1726], 'whole': [1729], 'Blood.': [1731, 1830], '78:': [1733], '1730–1737.CrossrefMedlineGoogle': [1734], 'Scholar6': [1735], 'Neumann': [1736, 1942, 2057], 'FJ,': [1737, 1943, 2058], 'Zohlnhofer': [1738], 'D,': [1739, 2455, 2595, 2957, 3083, 3103, 3436, 3501], 'Fakhoury': [1740], 'Effect': [1744], 'receptor': [1748], 'platelet-leukocyte': [1751], 'Mac-1': [1760, 1824], 'Am': [1766, 2004], 'Coll': [1767, 2005], 'Cardiol.': [1768, 2006], '1999;': [1769, 1858], '34:': [1770], '1420–1426.CrossrefMedlineGoogle': [1771], 'Scholar7': [1772], 'Gawaz': [1773, 1944, 2061], 'MP,': [1774], 'Loftus': [1775], 'JC,': [1776], 'Bajt': [1777], 'ML,': [1778], 'Ligand': [1781], 'bridging': [1782], 'mediates': [1783], 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'Aggregate': [2776], 'Formation': [2777, 3552], 'Acute': [2779], 'Coronary': [2780], 'Syndrome,': [2781], 'Haemostasis,': [2784, 3184], '10.1055/s-0040-1722226,': [2785], '121:07,': [2786], '(913-922),': [2787], '1-Jul-2021.': [2791], 'Bosco': [2792], 'Vizio': [2794], 'Gruden': [2796], 'Schiavello': [2798], 'Lorenzati': [2800], 'Cavallo-Perin': [2802], 'Russo': [2804, 2966], 'Montrucchio': [2806], 'Lupia': [2809], 'Thrombopoietin': [2812], 'Contributes': [2813], 'Enhanced': [2815], 'Activation': [2817], 'Type': [2821], 'Diabetes': [2823], 'Mellitus,': [2824], '10.3390/ijms22137032,': [2830], '22:13,': [2831], '(7032)': [2832], 'Cai': [2833], 'Zeng': [2835], 'Tan': [2837], 'Qian': [2841], 'Blood': [2851, 3201], 'Neutrophil-to-Lymphocyte': [2852, 3483], 'Ratio': [2853, 3207, 3484, 3487], 'Aneurysmal': [2855], 'Subarachnoid': [2856], 'Hemorrhage,': [2857], '10.3389/fneur.2021.671098,': [2861], '12': [2862], 'Pavlov': [2863], 'Chepanov': [2865, 3541], 'Selutin': [2867], 'Zainulina': [2869], 'Eremeeva': [2871], 'Selkov': [2874], 'Flow': [2877, 3025], 'cytofluorimetric': [2878], 'detection': [2879], 'immunophenotyping': [2881], 'platelet-monocyte': [2883], 'complexes': [2884], 'blood,': [2887], 'Immunology': [2889], '(Russia),': [2890], '10.15789/1563-0625-FCD-2124,': [2891], '23:2,': [2892], '(401-410)': [2893], 'Fu': [2894, 3359], 'Deng': [2896], 'Neal': [2898], 'Billiar': [2900], 'Scott': [2903], 'Platelet–Monocyte': [2906], 'Aggregates:': [2907], 'Understanding': [2908], 'Functions': [2911], 'Sepsis,': [2913], 'Shock,': [2914], '10.1097/SHK.0000000000001619,': [2915], '55:2,': [2916], '(156-166),': [2917], '1-Feb-2021.': [2921], 'Kheiabani': [2922], 'Inhibitory': [2934], 'Cinnamon': [2937], 'co-culture,': [2948], 'Koomesh': [2949], 'journal,': [2950], '10.29252/koomesh.23.1.139,': [2951], '23:1,': [2952], '(139-145)': [2953], 'Vinci': [2954], 'Pedicino': [2956], "D'Aiello": [2958], 'Ciampi': [2960], 'Ponzo': [2962], 'Bonanni': [2964], 'Montone': [2968], 'Massetti': [2970], 'Crea': [2972], 'Liuzzo': [2975], 'hyaluronidase': [2979], '2': [2980], 'enrichment': [2981], 'syndromes:': [2985], 'conceivable': [2987], 'formation,': [2992], 'Enzyme': [2995], 'Inhibition': [2996], 'Medicinal': [2998], 'Chemistry,': [2999], '10.1080/14756366.2021.1900159,': [3000], '36:1,': [3001], '(785-789),': [3002], '1-Jan-2021.': [3006, 3052], 'Trainor': [3011], 'Aladili': [3015], 'Owolabi': [3019], 'cytometric': [3026], 'evaluation': [3027], 'conjugate': [3030], 'stability': [3031], 'time:': [3033], 'methodological': [3034], 'implications': [3035], 'handling': [3038], 'processing,': [3040], 'Thrombolysis,': [3045], '10.1007/s11239-020-02186-5,': [3046], '51:1,': [3047], '(120-128),': [3048], 'McFadyen': [3053], 'Stevens': [3055], 'Peter': [3058], 'K': [3059, 3161], 'Emerging': [3062], 'Threat': [3063], '(Micro)Thrombosis': [3065], 'COVID-19': [3067], 'Therapeutic': [3070], 'Implications,': [3071], '127:4,': [3074], '(571-587),': [3075], '31-Jul-2020.': [3079], 'Hanlon': [3082], 'Arshad': [3084], 'Tatsuno': [3088], 'K,': [3089, 3148, 3243, 3578, 3739, 3883], 'Yurter': [3090], 'Robinson': [3092], 'Filler': [3094], 'Sobolev': [3096], 'Cote': [3098], 'Rivera-Molina': [3100], 'Toomre': [3102], 'Fahmy': [3104], 'Edelson': [3107], 'cross-presentation': [3113], 'dendritic': [3115], 'differentiation': [3117], 'Science': [3121, 3261], 'Advances,': [3122], '10.1126/sciadv.aaz1580,': [3123], '6:11,': [3124], '13-Mar-2020.': [3128], 'Gasecka': [3129], 'Nieuwland': [3131], 'Budnik': [3133], 'Dignat‐George': [3135], 'Eyileten': [3137], 'Harrison': [3139], 'Lacroix': [3141], 'Leroyer': [3143], 'Opolski': [3145], 'Pluta': [3147], 'der': [3150], 'Pol': [3151], 'Postuła': [3153], 'Siljander': [3155], 'Siller‐Matula': [3157], 'Filipiak': [3160], 'Ticagrelor': [3163], 'attenuates': [3164], 'extracellular': [3168], 'vesicle': [3169], 'plasma': [3172], 'clopidogrel,': [3179], '10.1111/jth.14689,': [3185], '18:3,': [3186], '(609-623),': [3187], '1-Mar-2020.': [3191], 'Hermawati': [3192], 'I': [3193, 3449, 3745], 'Assegaf': [3195], 'Association': [3198, 3673], 'White': [3200], 'Mean': [3204], 'Volume': [3206], '(WMR)': [3208], 'Troponin': [3210], 'Refractory': [3212], 'Angina': [3213], 'Prediction': [3214], 'NSTE-ACS': [3216], 'IOP': [3218], 'Conference': [3219], 'Series:': [3220], 'Earth': [3221], 'Environmental': [3223], 'Science,': [3224], '10.1088/1755-1315/441/1/012176,': [3225], '441:1,': [3226], '(012176),': [3227], '1-Feb-2020.': [3231], 'Barrett': [3232, 3394], 'Schlegel': [3234], 'Zhou': [3236], 'Gorenchtein': [3238], 'Bolstorff': [3240], 'Moore': [3242], 'Fisher': [3244], 'Berger': [3247, 3407], '(2019)': [3249, 3297, 3338, 3368, 3409, 3450, 3482], 'myeloid': [3253], 'suppressor': [3254], 'signaling': [3257], 'accelerates': [3259], 'atherosclerosis,': [3260], 'Translational': [3262], '10.1126/scitranslmed.aax0481,': [3264], '11:517,': [3265], '6-Nov-2019.': [3269], 'Lin': [3270, 3274, 3288, 3621], 'Tsai': [3272, 3295], 'Chang': [3276], 'Kung': [3282], 'Su': [3284, 3286, 3906], 'Cheng': [3290], 'Adjunctive': [3298], 'statin': [3299], 'reduces': [3301], 'intracranial': [3302], 'hemorrhage': [3303], '1-year': [3305], 'atrial': [3310], 'fibrillation': [3311], 'stroke:': [3315], 'population-based': [3317], 'epidemiological': [3318], 'Taiwan,': [3321], 'Neuroscience,': [3325], '10.1016/j.jocn.2019.07.045,': [3326], '69,': [3327], '(224-229),': [3328], '1-Nov-2019.': [3332], 'Jansson': [3333], 'Kay': [3336], 'B': [3337], 'Aldehydes': [3339], 'identified': [3340], 'commercially': [3342], 'available': [3343], 'ω-3': [3344], 'supplements': [3345], 'NMR': [3349], 'spectroscopy,': [3350], 'Nutrition,': [3351, 3771], '10.1016/j.nut.2018.10.004,': [3352], '60,': [3353], '(74-79),': [3354], '1-Apr-2019.': [3358], 'Jiang': [3363], 'Hu': [3366, 3902], 'Myocardial': [3369], 'bone': [3372], 'marrow': [3373], 'megakaryocyte': [3374], 'proliferation,': [3375], 'maturation': [3376], 'production,': [3379], 'Biochemical': [3380], 'Biophysical': [3382], 'Research': [3383], 'Communications,': [3384], '10.1016/j.bbrc.2019.01.129,': [3385], '510:3,': [3386], '(456-461),': [3387], '1-Mar-2019.': [3391, 3430, 3466], 'Allen': [3392], 'Guo': [3396, 3506], 'Nardi': [3398], 'Ramkhelawon': [3400], 'Rockman': [3402], 'Hochman': [3404], 'robust': [3415], 'activity': [3419], 'Atherosclerosis,': [3423], '10.1016/j.atherosclerosis.2018.12.029,': [3424], '282,': [3425], '(11-18),': [3426], 'Sotiri': [3431], 'Robichaud': [3433], 'Braune': [3437], 'Gorbet': [3439], 'Ratner': [3441], 'Brash': [3443], 'Latour': [3445], 'Reviakine': [3448], 'BloodSurf': [3451], '2017:': [3452], 'News': [3453], 'blood-biomaterial': [3456], 'frontier,': [3457], 'Biomaterialia,': [3459], '10.1016/j.actbio.2019.01.032,': [3460], '87,': [3461], '(55-60),': [3462], 'Shushan': [3467, 3783], 'Shemesh': [3469, 3781], 'Ungar': [3471], 'Cavel': [3473], 'Handzel': [3475], 'Tamir': [3477, 3793], 'Oron': [3480, 3779], 'Platelet-to-Lymphocyte': [3486], 'ORL,': [3493], '10.1159/000502152,': [3494], '81:5-6,': [3495], '(304-308),': [3496], 'Fan': [3504], 'Guan': [3509], 'Q': [3510], '(2018)': [3511, 3546, 3584, 3626, 3671, 3701, 3724], 'Correlation': [3512], 'vestibular': [3514, 3707], 'neuritis': [3515], 'cerebrovascular': [3517], 'risk': [3518], 'factors,': [3519], 'Otolaryngology,': [3523], '10.1016/j.amjoto.2018.08.006,': [3524], '39:6,': [3525], '(751-753),': [3526], '1-Nov-2018.': [3530], 'Veselkina': [3531], 'Petrishchev': [3533], 'Vasina': [3535], 'Borovitov': [3537], 'Selyutin': [3539], "Sel'kov": [3544], 'Effects': [3547], 'Nothrombel': [3549], 'Thrombin-Induced': [3551], 'Thrombocyte-Leukocyte': [3554], 'Complexes,': [3555], 'Neuroscience': [3556], 'Behavioral': [3558], 'Physiology,': [3559, 3607], '10.1007/s11055-018-0636-y,': [3560], '48:7,': [3561], '(830-834),': [3562], '1-Sep-2018.': [3566], 'Haynes': [3567], 'Linden': [3569], 'Robey': [3571], 'Naylor': [3573], 'Ainslie': [3575], 'Cox': [3577], 'Lautenschlager': [3579], 'Green': [3582], 'Beneficial': [3585], 'impacts': [3586], 'regular': [3588], 'exercise': [3589], 'function': [3592, 3758], 'sedentary': [3594, 3760], 'adults:': [3596], 'evidence': [3597], '6-mo': [3601], 'walking': [3602], 'trial,': [3603, 3767], 'Applied': [3606], '10.1152/japplphysiol.00079.2018,': [3608], '125:2,': [3609], '(401-408),': [3610], '1-Aug-2018.': [3614], 'Alshbool': [3615], 'Karim': [3617], 'Espinosa': [3619], 'O': [3622], 'Khasawneh': [3624], 'Investigation': [3627], 'Thromboxane': [3630], 'A2': [3631], 'Receptor–Based': [3632], 'Vaccine': [3633], 'Managing': [3635], 'Thrombogenesis,': [3636], 'Association,': [3642], '7:13,': [3643], '3-Jul-2018.': [3647], 'Zamora': [3648], 'Canto': [3650], 'Nieto': [3652], 'Garcia-Planella': [3654], 'Gordillo': [3656], 'Ortiz': [3658], 'Suarez-Calvet': [3660], 'Perea': [3662], 'Julia': [3664], 'Juarez': [3666], 'Vidal': [3669], 'Inverse': [3672], 'Between': [3674], 'Monocyte-Platelet': [3676], 'Complexes': [3677], 'Ulcerative': [3681], 'Colitis': [3682], 'Patients,': [3683], 'Inflammatory': [3684], 'Bowel': [3685], 'Diseases,': [3686], '10.1093/ibd/izx106,': [3687], '(818-828),': [3689], '19-Mar-2018.': [3693], "Pal'chun": [3694], 'Makoeva': [3696], 'Guseva': [3699], 'Dizziness': [3702], 'vertigo': [3704], 'neuronitis:': [3708], 'approaches': [3710], 'diagnostics': [3713], 'treatment,': [3715], 'Vestnik': [3716], 'otorinolaringologii,': [3717], '10.17116/otorino20188334,': [3718], '83:3,': [3719], '(4),': [3720], 'Shammas': [3722], 'Thrombotic': [3725], 'Lesions': [3726], 'Lower': [3729], 'Extremity': [3730], 'Peripheral': [3731, 3830], 'Arteries': [3732], 'Thrombus,': [3734], '10.1016/B978-0-12-812615-8.00032-6,': [3735], '(459-467),': [3736], 'Thompson': [3738], 'Hosking': [3740], 'Pederick': [3742], 'Santhakumar': [3747], '(2017)': [3749, 3795, 3822, 3859, 3913], 'anthocyanin': [3753], 'supplementation': [3754], 'modulating': [3756], 'population:': [3761], 'randomised,': [3763], 'double-blind,': [3764], 'placebo-controlled,': [3765], 'cross-over': [3766], 'British': [3768], '10.1017/S0007114517002124,': [3772], '118:5,': [3773], '(368-374),': [3774], '14-Sep-2017.': [3778], 'Cinamon': [3785], 'U,': [3786], 'Goldfarb': [3787], 'Dabby': [3789], 'Ovnat': [3792], 'Risk': [3797], 'Factors': [3798], 'Among': [3799], 'Annals': [3804], 'Otology,': [3806], 'Rhinology': [3807], 'Laryngology,': [3809], '10.1177/0003489417718846,': [3810], '126:8,': [3811], '(597-601),': [3812], '1-Aug-2017.': [3816], 'Hegemann': [3817], 'Wenzel': [3820], 'Diagnosis': [3823], 'Treatment': [3825], 'Neuritis/Neuronitis': [3828], 'Vestibulopathy': [3831], '(PVP)?': [3832], 'Open': [3833], 'Questions': [3834], 'Possible': [3836], 'Answers,': [3837], 'Otology': [3838, 3872], 'Neurotology,': [3840, 3874], '10.1097/MAO.0000000000001396,': [3841], '38:5,': [3842, 3876], '(626-631),': [3843], '1-Jun-2017.': [3847, 3881], 'Chung': [3848], 'Park': [3852], 'Jeong': [3854], 'Significance': [3861], 'Arterial': [3863], 'Stiffness': [3864], 'Metabolic': [3866], 'Syndrome': [3867], 'Scores': [3868], '10.1097/MAO.0000000000001352,': [3875], '(737-741),': [3877], 'Du': [3884], 'He': [3904], 'Indoxyl': [3914], 'sulfate': [3915], 'contributes': [3920], 'disease–associated': [3924], 'mice,': [3927], 'Blood,': [3928], '10.1182/blood-2016-10-744060,': [3929], '129:19,': [3930], '(2667-2679),': [3931], '11-May-2017.': [3935], 'Manne': [3936], 'Xiang': [3938], 'Rondina': [3941], '(2016)': [3943], 'secretion': [3945], 'infectious': [3949], 'diseases,': [3950], '10.1080/09537104.2016.1240766,': [3952], '28:2,': [3953], '(1': [3954]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2102667962', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 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