Publication Information

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3719, 3730, 3741, 3806, 3883, 3922, 4038, 4050, 4079, 4087, 4116, 4122, 4128, 4155, 4167], 'protein': [8, 216, 504, 513, 559, 765, 1093, 1324, 1408, 1646], 'lysine': [9, 52, 191, 206, 217, 260, 399, 414, 417, 505, 514, 560, 1419, 1447, 2235, 3769], 'methyltransferases': [10, 40, 218, 248, 506, 777], 'in': [11, 136, 166, 181, 194, 219, 344, 374, 389, 402, 426, 490, 748, 1053, 1138, 1327, 1356, 1639, 2149, 2163, 2183, 2234, 2270, 2436, 2457, 2484, 2534, 2601, 2659, 2670, 2680, 2725, 2734, 2908, 2921, 2935, 3139, 3158, 3193, 3305, 3319, 3532, 3641, 3654, 3664, 3753, 3765, 3819, 3832, 3919, 3996, 4010, 4025, 4059, 4071, 4103, 4151], 'eukaryotes.': [12, 220], 'Recent': [13, 221], 'studies': [14, 222, 1456], 'have': [15, 62, 223, 270, 755, 1080, 1163, 2177, 2584, 3736], 'yielded': [16, 224], 'significant': [17, 225], 'insights': [18, 226, 759, 1428, 2262], 'into': [19, 227, 760, 1340, 1371, 1385, 2263, 2378, 2567, 2917, 3414, 3906], 'the': [20, 27, 34, 42, 45, 51, 64, 67, 91, 100, 119, 132, 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4016, 4019, 4026, 4035, 4047, 4066, 4076, 4084, 4094, 4097, 4104, 4113, 4119, 4125, 4152, 4162, 4168], 'structural': [21, 103, 229, 311, 684, 1432, 1455, 2242, 3317], 'basis': [22, 230], 'substrate': [24, 232, 766, 1094, 1110, 1173, 1325, 1329, 1402, 1409], 'recognition': [25, 233, 1410, 1826, 3732], 'and': [26, 82, 87, 89, 104, 123, 163, 193, 234, 290, 295, 297, 312, 331, 371, 401, 429, 444, 466, 653, 718, 753, 764, 962, 1092, 1109, 1134, 1446, 1472, 1969, 2095, 2097, 2187, 2196, 2201, 2226, 2241, 2259, 2273, 2278, 2284, 2286, 2325, 2355, 2376, 2389, 2399, 2403, 2445, 2460, 2491, 2530, 2548, 2590, 2611, 2666, 2676, 2732, 2762, 2845, 2927, 2971, 2976, 3005, 3075, 3128, 3203, 3233, 3265, 3299, 3312, 3374, 3477, 3497, 3606, 3661, 3713, 3725, 3747, 3761, 3770, 3803, 3809, 3815, 3829, 3968, 4002, 4042, 4046, 4083, 4118], 'product': [28, 149, 236, 357, 2232, 3628, 3666], 'specificities': [29, 237], 'these': [31, 94, 171, 239, 302, 379, 1078, 1431, 2206, 2268, 3320, 3349, 3518, 3692, 3697], 'enzymes.': [32, 240], 'However,': [33, 241], 'mechanism': [35, 243, 763, 1435], 'by': [36, 244, 1436, 1521, 1592, 2104, 2296, 2714, 3583, 3705, 3733, 3999], 'which': [37, 245, 715, 1088, 1113, 1130, 1345, 1360, 1437, 2518, 3388, 3589, 3649, 3688, 4054], 'catalyze': [41, 249], 'transfer': [43, 134, 188, 200, 251, 342, 396, 408, 1169, 1367, 1391, 1484, 2093, 2111, 2122, 2171, 2981, 3218, 3340, 3483, 3524, 3909, 4028, 4106], 'methyl': [46, 121, 133, 161, 185, 197, 254, 329, 341, 369, 393, 405, 1136, 1168, 1366, 1377, 1381, 1439, 1467, 1483, 2092, 2110, 2117, 2160, 2170, 2252, 2980, 3151, 3217, 3263, 3290, 3310, 3339, 3482, 3523, 3530, 3712, 3904, 3908, 4021, 4027, 4068, 4105], 'group': [47, 122, 186, 255, 330, 394, 1382, 1421, 1440, 1468, 2161, 3152, 3264, 3291, 3311, 3476, 3531, 3582, 3823, 3905, 4022, 4049, 4069, 4086, 4100, 4115], 'from': [48, 256, 1127, 1430, 2282, 2290, 2369, 2571, 2622, 2632, 2653, 3652], 'S-adenosyl-l-methionine': [49, 110, 257, 318, 688], 'to': [50, 80, 96, 189, 201, 258, 288, 304, 397, 409, 1363, 1554, 1645, 2157, 2208, 2223, 2251, 2328, 2453, 2499, 2575, 2614, 2721, 2913, 3206, 3235, 3261, 3344, 3351, 3356, 3359, 3392, 3404, 3466, 3488, 3505, 3511, 3546, 3562, 3570, 3576, 3604, 3676, 3722, 3745, 4007, 4135, 4175], 'ϵ-amine': [53, 192, 261, 400, 1395, 1420, 2107], 'has': [54, 262, 419], 'remained': [55, 263], 'unresolved.': [56, 264], 'To': [57, 265, 2173, 3363, 4142], 'elucidate': [58, 266, 3727], 'this': [59, 267, 494, 769, 1101, 2174, 3365, 3673], 'mechanism,': [60, 268], 'we': [61, 269, 1361, 1459, 2084, 2176, 2216, 3222, 3367, 3454, 3598, 3735, 4160], 'determined': [63, 271, 2178, 3223, 3368], 'structures': [65, 273, 742, 773, 1079, 2180, 2781, 2846, 3740, 3973], 'plant': [68, 276, 1048], 'enzyme,': [71, 279, 3387, 3648], 'pea': [72, 280, 551, 597, 997, 2528, 3386], 'ribulose-1,5': [73, 281, 538, 584], 'bisphosphate': [74, 282, 539, 585], 'carboxylase/oxygenase': [75, 283], 'large': [76, 284, 542, 588, 999, 1055], 'subunit': [77, 285, 543, 589, 1000], 'methyltransferase,': [78, 286], 'bound': [79, 287, 2222, 2254, 3744, 4102, 4174], 'S-adenosyl-l-methionine,': [81, 289], 'its': [83, 291, 1643, 2188, 2535, 2612, 3357, 3685, 3748], 'non-reactive': [84, 292], 'analogs': [85, 293, 2190, 2613, 3247, 3322], 'Aza-adenosyl-l-methionine': [86, 294], 'Sinefungin,': [88, 296, 3232, 3296, 4000], 'characterized': [90, 298], 'binding': [92, 300, 1095, 1111, 1174, 1330, 1374, 1403, 1448, 2204, 2467, 2582, 2585, 2608, 2624, 2634, 2655, 3229, 3347, 3375, 3403, 3432, 3437, 3504, 3561, 3567, 3601, 3624, 3896, 3914, 4013], 'ligands': [95, 303, 2207, 2912, 3350], 'homolog': [98, 306, 2210, 3237], 'enzyme.': [101, 309, 2213, 3564], 'The': [102, 310, 1323, 2780, 3243, 3316, 3406, 3427, 3565, 3812], 'biochemical': [105, 313, 2240], 'data': [106, 314, 2243, 2576, 2926, 3004, 3065, 3118, 3519, 3698], 'collectively': [107, 315], 'reveal': [108, 316, 3699], 'that': [109, 130, 317, 338, 642, 1050, 1369, 1480, 1588, 1599, 2086, 3257, 3456, 3521, 3551, 3608, 3635, 3700, 3993], 'is': [111, 319, 1103, 1383, 1441, 1450, 1600, 1629, 2531, 3062, 3115, 3281, 3389, 3556, 3572, 3639, 3702, 3916, 4023, 4055, 4101, 4130], 'selectively': [112, 320, 3703], 'recognized': [113, 321, 3704], 'through': [114, 322, 1422, 3707, 4030, 4108], 'carbon-oxygen': [115, 156, 178, 323, 364, 386, 524, 570, 1461, 4147], 'hydrogen': [116, 179, 324, 387, 1463, 1508, 1530, 1550, 1561, 1597, 1637, 2088, 2147, 2249, 2941, 2944, 2973, 3145, 3469, 4110, 4138], 'bonds': [117, 325, 1509, 1551, 1562, 3663, 4111], 'between': [118, 158, 326, 366, 1170, 1443, 1465, 2090, 2588, 3471], "cofactor's": [120, 184, 328, 392, 1380, 3309, 3529, 3553, 4020], 'an': [124, 332, 1513, 1522, 2370, 2520, 2922, 3415, 3611, 3636, 3900, 4056], 'array': [125, 154, 333, 362, 450], 'structurally': [127, 335, 1476, 3917], 'conserved': [128, 336, 635, 1477, 3918], 'oxygens': [129, 165, 337, 373, 3479, 4037], 'comprise': [131, 339, 1481], 'pore': [135, 343, 1387, 1485, 2094, 2112, 2982, 3219, 3525, 3910, 4029, 4107], 'active': [138, 346, 2151, 2536, 2919, 3452, 4153], 'site.': [139, 347, 2396, 2537], 'Furthermore,': [140, 348], 'structure': [142, 350, 2079, 2219, 2932, 4166], 'enzyme': [145, 353, 1049, 1970, 2529, 2549, 3240, 3507, 3743, 3924], 'co-crystallized': [146, 354, 3764], 'with': [147, 355, 497, 686, 750, 1393, 1603, 2185, 2384, 2475, 2510, 2526, 2541, 2561, 2672, 2729, 2849, 2985, 3259, 3418, 3434, 3490, 3528, 3534, 3619, 3646, 3710, 3757, 3768, 3824, 4034, 4075, 4112], 'ϵ-N-trimethyllysine': [150, 358, 2224], 'reveals': [151, 359], 'trigonal': [153, 361], 'interactions': [157, 365, 1605, 1862, 2162, 2269, 3210, 3331, 3709, 4033, 4148], 'ϵ-ammonium': [160, 368], 'groups': [162, 198, 370, 406, 1590, 2118, 2253, 3335, 3715], 'pore.': [168, 376, 2172, 3341, 3484], 'Taken': [169, 377, 2237], 'together,': [170, 378, 2238], 'results': [172, 380], 'establish': [173, 381], 'central': [175, 383], 'role': [176, 384], 'for': [177, 187, 385, 395, 645, 1388, 2247, 2595, 2930, 3008, 3148, 3227, 3250, 3283, 3293, 3327, 3463, 3558, 3615, 3782], 'bonding': [180, 388, 1464, 1598, 1638, 2089, 2148, 2250, 2942, 3470, 4139], 'aligning': [182, 390], 'coordinating': [195, 403], 'after': [199, 407], 'facilitate': [202, 410], 'multiple': [203, 411], 'rounds': [204, 412, 1424, 2101], 'methylation.': [207, 415], 'Protein': [416, 3046], 'methylation': [418, 437, 2103], 'emerged': [420], 'as': [421, 696, 910, 994, 996, 1332, 1364, 2194, 2299, 2405, 2688, 2794, 3778, 3836], 'prominent': [423], 'post-translational': [424], 'modification': [425, 495], 'gene': [427, 457, 648], 'regulatory': [428, 649], 'intracellular': [430], 'signaling': [431], 'pathways.': [432], 'In': [433, 486, 1453, 2214, 3276, 3295, 3695, 4015, 4093], 'nucleus,': [435], 'site-specific': [436], 'lysines': [439], 'within': [440, 453, 2168, 2255, 2978, 3153, 3215, 3336, 3893], 'histones,': [441], 'transcription': [442], 'factors,': [443, 650], 'mitotic': [445], 'proteins': [446, 2450], 'governs': [447], 'diverse': [449], 'processes': [452], 'nucleus': [455], 'including': [456], 'expression,': [458], 'DNA': [459, 2357], 'damage': [460], 'checkpoint': [461], 'control,': [462], 'cell': [463, 3013, 3827], 'cycle': [464], 'progression,': [465], 'mitosis': [467], '(1Dillon': [468, 721], 'S.C.': [469, 722], 'Zhang': [470, 723, 2007], 'X.': [471, 475, 724, 728, 966, 978, 1276, 1288], 'Trievel': [472, 725, 893, 918, 1211, 1231], 'R.C.': [473, 726, 894, 919, 1004, 1028, 1212, 1232, 1305, 1487, 2125, 2409, 2692, 2799, 3785, 3840, 3864, 3926, 3950], 'Cheng': [474, 727, 977, 1287], 'Genome': [476, 729], 'Biol.': [477, 730, 793, 898, 1037, 1216, 1314, 1496, 1540, 1613, 1656, 1671, 1692, 1708, 1744, 1761, 1775, 1810, 1837, 1979, 1996, 2134, 2311, 2701, 2808, 2889, 2961, 3794, 3873, 3959, 3983], '2005;': [478, 731, 922, 954, 1235, 1267, 1961], '6:': [479, 732], '227Crossref': [480, 733], 'PubMed': [481, 626, 672, 734, 823, 849, 882, 902, 925, 957, 989, 1022, 1041, 1072, 1152, 1200, 1220, 1238, 1270, 1299, 1318, 1500, 1544, 1623, 1660, 1675, 1697, 1712, 1733, 1748, 1765, 1785, 1798, 1820, 1841, 1856, 1894, 1909, 1927, 1940, 1964, 1983, 2000, 2026, 2054, 2138, 2319, 2427, 2705, 2812, 2840, 2894, 2966, 2996, 3798, 3858, 3877, 3944, 3963, 3987], 'Scopus': [482, 627, 673, 735, 824, 850, 883, 903, 926, 958, 990, 1023, 1042, 1073, 1153, 1201, 1221, 1239, 1271, 1300, 1319, 1501, 1545, 1578, 1624, 1661, 1676, 1698, 1713, 1734, 1749, 1766, 1786, 1799, 1821, 1842, 1857, 1895, 1910, 1928, 1941, 1965, 1984, 2001, 2027, 2055, 2072, 2139, 2349, 2428, 2706, 2776, 2813, 2841, 2895, 2967, 2997, 3799, 3859, 3878, 3945, 3964, 3988], '(547)': [483, 736], 'Google': [484, 629, 675, 737, 797, 826, 852, 885, 905, 928, 960, 992, 1025, 1044, 1075, 1155, 1203, 1223, 1241, 1273, 1302, 1321, 1503, 1547, 1580, 1626, 1663, 1678, 1700, 1715, 1736, 1751, 1768, 1788, 1801, 1823, 1844, 1859, 1897, 1912, 1930, 1943, 1967, 1986, 2003, 2029, 2057, 2074, 2141, 2320, 2351, 2430, 2708, 2778, 2815, 2843, 2897, 2969, 2999, 3801, 3861, 3880, 3947, 3966, 3990], 'Scholar).': [485, 630, 676, 1076, 1156, 1322, 1504, 1548, 1627, 2075, 2321, 2431, 2709, 2779, 2816, 2898], '2000,': [487], 'breakthrough': [489], 'our': [491, 3448], 'understanding': [492], 'occurred': [496], 'discovery': [499, 704], 'first': [502], 'histone-specific': [503], '(PKMTs)': [507], '4The': [508, 554], 'abbreviations': [509, 555], 'used': [510, 556], 'are:': [511, 557], 'PKMT,': [512, 558], 'methyltransferase;': [515, 561], 'AdoHcy,': [516, 562, 3201], 'S-adenosyl-l-homocysteine;': [517, 563], 'AdoMet,': [518, 564, 2673, 3200, 3231, 3549, 3723], 'S-adenosyl-l-methionine;': [519, 565], 'CH···O,': [520, 566], 'carbon': [521, 567, 1517], '(hydrogen)-oxygen;': [522, 568], 'dco,': [523, 569], 'distance;': [525, 528, 571, 574], 'dH,': [526, 572], 'hydrogen-oxygen': [527, 573], 'ITC,': [529, 575, 2505], 'isothermal': [530, 576, 2471], 'titration': [531, 577, 2472, 2506, 2597, 3411], 'calorimetry;': [532, 578], 'MeLys,': [533, 579, 3771], 'ϵ-N-monomethyllysine;': [534, 580], 'Me3Lys,': [535, 581], 'ϵ-N-trimethyllysine;': [536, 582], 'Rubisco,': [537, 583], 'carboxylase/oxygenase;': [540, 586], 'LSMT,': [541, 587], 'N-methyltransferase;': [544, 590], 'aLSMT,': [545, 591, 2511, 3379], 'A.': [546, 592, 658, 837, 1718, 1729, 1870, 2338, 2767, 2836], 'thaliana': [547, 593, 2363], 'Rubisco': [548, 552, 594, 598, 998, 1059, 2364], 'LSMT;': [549, 595], 'pLSMT,': [550, 596, 1458, 2517, 3221, 3734, 3758], 'LSMT.': [553, 599], '(2Rea': [600], 'S.': [601, 613, 784, 790, 812, 855, 1189, 1607, 1683, 1705, 1728, 1793, 1933, 2036], 'Eisenhaber': [602], 'F.': [603, 788], "O'Carroll": [604], 'D.': [605, 877, 947, 1260, 1917, 2038], 'Strahl': [606], 'B.D.': [607], 'Sun': [608], 'Z.W.': [609], 'Schmid': [610], 'M.': [611, 1064, 1847, 2010, 2046, 2832, 2874], 'Opravil': [612], 'Mechtler': [614], 'K.': [615, 867, 945, 1258, 1791], 'Ponting': [616], 'C.P.': [617], 'Allis': [618, 1974], 'C.D.': [619, 1975], 'Jenuwein': [620], 'T.': [621, 829, 1609, 1878, 2882, 4178], 'Nature.': [622, 819, 878, 1196], '2000;': [623, 1575, 2051], '406:': [624], '593-599Crossref': [625], '(2152)': [628], 'These': [631, 772, 3632, 3773], 'possess': [633, 1555, 3254], 'catalytic': [636, 762, 2265], 'domain,': [638, 2166], '120-residue': [640], 'motif': [641], 'was': [643, 2293, 2323, 2367, 2468, 2820, 3751], 'named': [644], 'three': [646, 3155, 3830], 'Drosophila': [647], 'SU(VAR)3-9,': [651], 'E(Z),': [652], 'TRX': [654], '(3Tschiersch': [655], 'B.': [656, 800, 861, 931, 1177, 1244, 1915, 2034, 2048, 2068, 3975], 'Hofmann': [657], 'Krauss': [659], 'V.': [660, 1685, 1687, 2305], 'Dorn': [661], 'R.': [662, 1564, 1876, 1880], 'Korge': [663], 'G.': [664, 666, 810, 892, 935, 1187, 1210, 1248, 1868], 'Reuter': [665], 'EMBO': [667, 844, 2049], 'J.': [668, 841, 845, 1538, 1566, 1571, 1612, 1654, 1666, 1669, 1706, 1742, 1759, 1774, 1809, 1835, 1850, 1958, 1994, 2042, 2044, 2050, 2065, 2310, 2343, 2770, 2872], '1994;': [669, 1997], '13:': [670, 900, 1218, 1981, 3985], '3822-3831Crossref': [671], '(469)': [674], 'This': [677, 702, 1123, 1353, 1505, 3913], 'shares': [679, 2519], 'no': [680], 'apparent': [681], 'sequence': [682, 2522], 'or': [683, 1415, 1515, 3902], 'homology': [685], 'other': [687, 1128, 3969, 4156], '(AdoMet)-dependent': [689], 'enzymes,': [690], 'establishing': [691], 'novel': [698, 1085], 'class': [699], 'methyltransferases.': [701], 'seminal': [703], 'heralded': [705], 'identification': [707], 'multitude': [710], 'PKMTs,': [714, 4159], 'methylate': [716], 'histone': [717, 776, 4169], 'non-histone': [719], 'substrates': [720, 752, 3781], 'Scholar).Since': [738], 'their': [739, 4011], 'identification,': [740], 'crystal': [741, 3739], 'several': [744, 1159], 'PKMTs': [747, 4062], 'complex': [749, 2184, 2233, 2671, 3756], 'various': [751, 2542, 2784], 'products': [754], 'been': [756], 'reported,': [757], 'yielding': [758], 'specificity': [767], 'methyltransferase': [770, 1001, 4172], 'family.': [771], 'include': [774], 'SET7/9': [778, 4173], '(4Jacobs': [779], 'S.A.': [780], 'Harp': [781], 'J.M.': [782], 'Devarakonda': [783], 'Kim': [785, 838], 'Y.': [786, 843, 1611, 1828, 2008], 'Rastinejad': [787], 'Khorasanizadeh': [789], 'Nat.': [791, 895, 1035, 1213, 1312, 1494, 2132, 2699, 2806, 3792, 3871, 3957], 'Struct.': [792, 896, 1036, 1214, 1313, 1495, 2133, 2700, 2807, 3793, 3872, 3958, 3982], '2002;': [794, 1014, 1144, 1745, 1762, 1777, 1812, 1906, 1919, 2069, 2419, 3850, 3936], '9:': [795], '833-838PubMed': [796], 'Scholar,': [798, 827, 853, 886, 929, 1026, 1204, 1224, 1242, 1274, 1303, 1664, 1679, 1701, 1716, 1737, 1752, 1769, 1789, 1845, 1898, 1913, 1931, 1944, 1987, 2004, 2030, 2058, 3862, 3948], '5Xiao': [799], 'Jing': [801, 932, 1178, 1245], 'C.': [802, 871, 933, 1179, 1246, 2040, 2062], 'Wilson': [803, 858, 950, 1180, 1263, 3976], 'J.R.': [804, 859, 951, 972, 1181, 1264, 1282, 3977], 'Walker': [805, 936, 1182, 1249], 'P.A.': [806, 937, 1183, 1250], 'Vasisht': [807, 1184], 'N.': [808, 863, 1185, 2989], 'Kelly': [809, 934, 1186, 1247], 'Howell': [811, 1188], 'Taylor': [813, 1190], 'I.A.': [814, 1191], 'Blackburn': [815, 1192, 2341], 'G.M.': [816, 1193, 2342, 2862], 'Gamblin': [817, 872, 948, 1194, 1261, 3978], 'S.J.': [818, 873, 949, 1195, 1262, 3979], '2003;': [820, 846, 981, 1038, 1197, 1291, 1315, 1497, 2135, 2702, 2809, 3795, 3874, 3960, 3984], '421:': [821, 1198], '652-656Crossref': [822, 1199], '(302)': [825, 1202], '6Kwon': [828], 'Chang': [830, 4179], 'J.H.': [831, 1012, 1034, 1311, 1493, 2131, 2417, 2698, 2805, 3791, 3848, 3870, 3934, 3956], 'Kwak': [832], 'E.': [833, 890, 915, 1208, 1228, 1849, 1949], 'Lee': [834, 840, 1534, 1650], 'C.W.': [835], 'Joachimiak': [836], 'Y.C.': [839], 'Cho': [842], '22:': [847], '292-303Crossref': [848], '(105)': [851], '7Chuikov': [854], 'Kurash': [856], 'J.K.': [857], 'Xiao': [860], 'Justin': [862], 'Ivanov': [864], 'G.S.': [865], 'McKinney': [866], 'Tempst': [868], 'P.': [869, 1703, 1758, 1957, 2032, 2866], 'Prives': [870], 'Barlev': [874], 'N.A.': [875], 'Reinberg': [876, 946, 1259], '2004;': [879, 1795, 1937, 2963], '432:': [880], '353-360Crossref': [881], '(622)': [884], '8Couture': [887, 1205], 'J.F.': [888, 913, 1206, 1226], 'Collazo': [889, 914, 1207, 1227], 'Hauk': [891, 1209], 'Mol.': [897, 979, 1215, 1289, 1539, 1655, 1670, 1707, 1743, 1760, 1836, 1851, 1995], '2006;': [899, 1217], '140-146Crossref': [901, 1219], '(136)': [904, 1222], 'Scholar),': [906, 961, 1045, 1581, 1802, 1824, 1860, 1968, 2844, 2970, 3991], 'SET8': [907], '(also': [908, 2192], 'known': [909, 2193], 'PR-SET7)': [911], '(9Couture': [912], 'Brunzelle': [916, 1229], 'J.S.': [917, 1230, 2870], 'Genes': [920, 952, 1233, 1265], 'Dev.': [921, 953, 1234, 1266], '19:': [923, 955, 1236, 1268, 2052], '1455-1465Crossref': [924, 1237], '(186)': [927, 1240, 1787, 1822], '10Xiao': [930, 1243], 'Muskett': [938, 1251], 'F.W.': [939, 1252], 'Frenkiel': [940, 1253], 'T.A.': [941, 1254, 2826], 'Martin': [942, 1255], 'S.R.': [943, 1256, 1955], 'Sarma': [944, 1257], '1444-1454Crossref': [956, 1269], '(152)': [959, 1272], 'Neurospora': [963], 'DIM-5': [964], '(11Zhang': [965], 'Yang': [967, 1277], 'Z.': [968, 1278], 'Khan': [969, 1279], 'S.I.': [970, 1280], 'Horton': [971, 1281], 'Tamaru': [973, 1283], 'H.': [974, 1284, 1830, 1866], 'Selker': [975, 1285], 'E.U.': [976, 1286], 'Cell.': [980, 1013, 1143, 1290, 2418, 3849, 3935], '12:': [982, 1292], '177-185Abstract': [983, 1293], 'Full': [984, 986, 1017, 1019, 1147, 1149, 1294, 1296, 1618, 1620, 1780, 1782, 1815, 1817, 1889, 1891, 1922, 1924, 2021, 2023, 2316, 2422, 2424, 3853, 3855, 3939, 3941], 'Text': [985, 987, 1018, 1020, 1148, 1150, 1295, 1297, 1619, 1621, 1781, 1783, 1816, 1818, 1890, 1892, 1923, 1925, 2022, 2024, 2317, 2423, 2425, 3854, 3856, 3940, 3942], 'PDF': [988, 1021, 1151, 1298, 1622, 1784, 1819, 1893, 1926, 2025, 2318, 2426, 3857, 3943], '(270)': [991, 1301], 'Scholar)': [993, 3000, 3802, 3967], 'well': [995], '(pLSMT)': [1002], '(12Trievel': [1003, 2408, 3839, 3925], 'Beach': [1005, 2410, 3841, 3927], 'B.M.': [1006, 2411, 3842, 3928], 'Dirk': [1007, 2412, 3843, 3929], 'L.M.': [1008, 2413, 2880, 3844, 3930], 'Houtz': [1009, 1031, 1308, 1490, 2128, 2414, 2695, 2802, 3788, 3845, 3867, 3931, 3953], 'R.L.': [1010, 1032, 1062, 1309, 1491, 1832, 2129, 2415, 2696, 2803, 3789, 3846, 3868, 3932, 3954], 'Hurley': [1011, 1033, 1310, 1492, 2130, 2416, 2697, 2804, 3790, 3847, 3869, 3933, 3955], '111:': [1015, 1145, 2420, 3851, 3937], '91-103Abstract': [1016, 2421, 3852, 3938], '(206)': [1024, 2429, 3860, 3946], '13Trievel': [1027, 1304, 3863, 3949], 'Flynn': [1029, 1306, 1488, 2126, 2693, 2800, 3786, 3865, 3951], 'E.M.': [1030, 1307, 1489, 2127, 2694, 2801, 3787, 3866, 3952], '10:': [1039, 1316, 1498, 1920, 2136, 2703, 2810, 3796, 3875, 3961], '545-552Crossref': [1040, 1317, 1499, 2137, 2704, 2811, 3797, 3876, 3962], '(99)': [1043, 1320, 1502, 2140, 2707, 2814, 3800, 3879, 3965], 'non-histone-specific': [1047], 'trimethylates': [1051], 'Lys-14': [1052], 'subunits': [1056], 'holoenzyme': [1060], '(14Houtz': [1061], 'Royer': [1063], 'Salvucci': [1065], 'M.E.': [1066], 'Plant': [1067], 'Physiol.': [1068], '1991;': [1069, 2837], '97:': [1070], '913-920Crossref': [1071], '(23)': [1074], 'Together,': [1077], 'elucidated': [1081, 1164], "domain's": [1084], 'β-sheet': [1086], 'architecture,': [1087], 'harbors': [1089], 'AdoMet': [1091, 1133, 1373, 2186, 2292, 2610, 2949, 3150, 3269, 3285, 3402, 3413, 3486, 3620, 3669, 3701, 3746, 3750, 3895, 4003, 4176], 'sites.': [1096], 'A': [1097], 'distinctive': [1098], 'feature': [1099], 'fold': [1102], 'arrangement': [1105, 1399], 'cofactor': [1108, 1445, 3246, 3321, 3731, 3888], 'clefts,': [1112], 'are': [1114, 1552, 2599, 2933, 3271, 3303, 4004, 4149], 'located': [1115], 'on': [1116, 2077, 2741, 3447], 'opposing': [1117], 'faces': [1118], 'domain.': [1122, 1352], 'configuration': [1124], 'differs': [1125], 'significantly': [1126], 'methyltransferases,': [1129], 'generally': [1131], 'bind': [1132], 'acceptor': [1137], 'adjoining': [1139], 'clefts': [1140], '(15Yeates': [1141], 'T.O.': [1142], '5-7Abstract': [1146], '(57)': [1154], 'Structures': [1157], 'PKMT': [1160], 'ternary': [1161, 3766, 3816], 'complexes': [1162, 2786, 3767, 3817, 3921], 'path': [1166, 2123], 'two': [1172, 3245], 'sites': [1175, 1404, 1449, 4154], '(5Xiao': [1176], '9Couture': [1225], '11Zhang': [1275], 'intercalates': [1326], 'cleft': [1331], 'parallel': [1333], 'β-strand,': [1334], 'depositing': [1335], 'lysyl': [1337], 'side': [1338], 'chain': [1339], 'narrow': [1342, 1358], 'hydrophobic': [1343], 'channel,': [1344], 'traverses': [1346], 'core': [1348], 'channel': [1354], 'terminates': [1355], 'aperture,': [1359], 'refer': [1362], 'pore,': [1368], 'opens': [1370], 'cleft.': [1375], 'During': [1376], 'transfer,': [1378], 'positioned': [1384], 'SN2-based': [1390], 'reaction': [1392], 'group.': [1396], 'Thus,': [1397], 'promotes': [1405], 'highly': [1406], 'specific': [1407, 3708], 'while': [1411, 2113], 'permitting': [1412], 'mono-,': [1413], 'di-,': [1414], 'trimethylation': [1416], 'iterative': [1423], 'catalysis.Despite': [1426], 'obtained': [1429, 2289, 2679], 'studies,': [1433], 'transferred': [1442], 'poorly': [1451], 'understood.': [1452], 'prior': [1454, 2574], 'reported': [1460, 2300, 2406, 2600, 2689, 3837], '(CH···O)': [1462], 'N-ϵ-monomethyllysine': [1470], '(MeLys)': [1471], 'set': [1474, 3066, 3076, 3119, 3129], 'oxygen': [1478, 4078, 4121, 4127], 'atoms': [1479, 1531, 2945], '(13Trievel': [1486, 2124, 2691, 2798, 3784], 'category': [1506], 'can': [1510, 1595], 'occur': [1511], 'when': [1512, 3617], 'aliphatic': [1514], 'aromatic': [1516], 'atom': [1518], 'becomes': [1519], 'polarized': [1520, 1591], 'adjacent': [1523], 'covalently': [1524], 'bonded': [1525], 'heteroatom,': [1526], 'acidifying': [1527], 'CH': [1529, 1589], '(16Derewenda': [1532, 1648], 'Z.S.': [1533, 1649, 1989], 'L.': [1535, 1651, 1771, 1773, 1806, 1808], 'Derewenda': [1536, 1652, 1990], 'U.': [1537, 1653, 1727, 1872, 1991], '1995;': [1541, 1657], '252:': [1542, 1658], '248-262Crossref': [1543, 1659], '(497)': [1546, 1662], 'CH···O': [1549, 1636, 2087, 2146, 2248, 2940, 2972], 'estimated': [1553], 'half': [1556], 'energy': [1558], 'conventional': [1560, 3467, 4137], '(17Vargas': [1563], 'Garza': [1565], 'Dixon': [1567], 'D.A.': [1568], 'Hay': [1569], 'B.P.': [1570], 'Am.': [1572], 'Chem.': [1573, 1614, 1776, 1811, 1960, 2067, 2312, 2345], 'Soc.': [1574], '122:': [1576], '4750-4755Crossref': [1577], '(394)': [1579], 'although': [1582], 'recent': [1583], 'ab': [1584], 'initio': [1585], 'calculations': [1586], 'suggest': [1587, 3520], 'neighboring': [1593], 'cations': [1594], 'engage': [1596, 4136], 'energetically': [1601], 'comparable': [1602], 'OH···O': [1604], '(18Scheiner': [1606], 'Kar': [1608], 'Gu': [1610], '2001;': [1615, 1730, 1853, 1980], '276:': [1616], '9832-9837Abstract': [1617], '(278)': [1625], 'There': [1628], 'growing': [1631], 'body': [1632], 'literature': [1634], 'describing': [1635], 'macromolecular': [1640], 'structure,': [1641], 'emphasizing': [1642], 'contributions': [1644], 'folding': [1647], '19Bella': [1665], 'Berman': [1667], 'H.M.': [1668, 1951], '1996;': [1672, 1886], '264:': [1673], '734-742Crossref': [1674], '(196)': [1677], '20Fabiola': [1680], 'G.F.': [1681], 'Krishnaswamy': [1682], 'Nagarajan': [1684], 'Pattabhi': [1686], 'Acta': [1688, 2833, 2885, 2957], 'Crystallogr.': [1689, 1693, 2772, 2834, 2886, 2890, 2958, 2962], 'Sect.': [1690, 2835, 2887, 2959], 'D': [1691, 2888, 2960], '1997;': [1694, 2993], '53:': [1695], '316-320Crossref': [1696], '(148)': [1699], '21Chakrabarti': [1702], 'Chakrabarti': [1704], '1998;': [1709, 1838, 2891], '284:': [1710], '867-873Crossref': [1711], '(169)': [1714], '22Senes': [1717], 'Ubarretxena-Belandia': [1719], 'I.': [1720], 'Engelman': [1721], 'D.M.': [1722, 2956], 'Proc.': [1723], 'Natl.': [1724], 'Acad.': [1725], 'Sci.': [1726], '98:': [1731], '9056-9061Crossref': [1732], '(435)': [1735], '23Chamberlain': [1738], 'A.K.': [1739], 'Bowie': [1740], 'J.U.': [1741], '322:': [1746, 1763], '497-503Crossref': [1747], '(28)': [1750], '24Babu': [1753], 'M.M.': [1754], 'Singh': [1755], 'S.K.': [1756], 'Balaram': [1757], '871-880Crossref': [1764], '(84)': [1767, 1929], '25Jiang': [1770], 'Lai': [1772, 1807], '277:': [1778, 1813, 1839], '37732-37740Abstract': [1779, 1814], '26Manikandan': [1790], 'Ramakumar': [1792], 'Proteins.': [1794, 1905, 1936], '56:': [1796], '768-781Crossref': [1797], '(93)': [1800], 'protein-protein': [1803], 'interfaces': [1804], '(25Jiang': [1805], 'protein-nucleotide': [1825], '(27Mandel-Gutfreund': [1827], 'Margalit': [1829], 'Jernigan': [1831], 'Zhurkin': [1833], 'V.B.': [1834], '1129-1140Crossref': [1840], '(160)': [1843], '28Treger': [1846], 'Westhof': [1848], 'Recognit.': [1852], '14:': [1854], '199-214Crossref': [1855], '(134)': [1858], 'protein-ligand': [1861], '(29Engh': [1863], 'R.A.': [1864], 'Brandstetter': [1865], 'Sucher': [1867], 'Eichinger': [1869], 'Baumann': [1871], 'Bode': [1873], 'W.': [1874, 1884], 'Huber': [1875], 'Poll': [1877], 'Rudolph': [1879], 'von': [1881], 'der': [1882], 'Saal': [1883], 'Structure.': [1885, 1918, 2017], '4:': [1887], '1353-1362Abstract': [1888], '(113)': [1896], '30Pierce': [1899], 'A.C.': [1900, 1946], 'Sandretto': [1901], 'K.L.': [1902], 'Bemis': [1903], 'G.W.': [1904], '49:': [1907], '567-576Crossref': [1908], '(203)': [1911, 2002], '31Klaholz': [1914], 'Moras': [1916], '1197-1204Abstract': [1921], '32Sarkhel': [1932], 'Desiraju': [1934], 'G.R.': [1935], '54:': [1938, 2892], '247-259Crossref': [1939], '(242)': [1942], '33Pierce': [1945], 'ter': [1947], 'Haar': [1948], 'Binch': [1950], 'Kay': [1952], 'D.P.': [1953, 2340], 'Patel': [1954], 'Li': [1956], 'Med.': [1959], '48:': [1962], '1278-1281Crossref': [1963], '(77)': [1966], 'catalysis': [1971], '(34Rice': [1972], 'J.C.': [1973], 'Curr.': [1976, 3980], 'Opin.': [1977, 3981], 'Cell': [1978], '263-273Crossref': [1982], '(557)': [1985], '35Derewenda': [1988], 'Kobos': [1992], 'P.M.': [1993], '241:': [1998], '83-93Crossref': [1999], '36Bond': [2005], 'C.S.': [2006], 'Berriman': [2009], 'Cunningham': [2011], 'M.L.': [2012], 'Fairlamb': [2013], 'A.H.': [2014], 'Hunter': [2015], 'W.N.': [2016], '1999;': [2018, 2346], '7:': [2019], '81-89Abstract': [2020], '(190)': [2028], '37Meyer': [2031], 'Schneider': [2033], 'Sarfati': [2035], 'Deville-Bonne': [2037], 'Guerreiro': [2039], 'Boretto': [2041], 'Janin': [2043], 'Veron': [2045], 'Canard': [2047], '3520-3529Crossref': [2053], '(71)': [2056], '38Bach': [2059], 'R.D.': [2060], 'Thorpe': [2061], 'Dmitrenko': [2063], 'O.': [2064], 'Phys.': [2066], '106:': [2070], '4325-4335Crossref': [2071], '(33)': [2073], 'Based': [2076], 'pLSMT-MeLys': [2082], 'complex,': [2083, 4018, 4096], 'proposed': [2085], 'mono-': [2096], 'dimethyllysine': [2098], 'facilitates': [2099], 'subsequent': [2100], 'orienting': [2105], 'toward': [2108], 'rotating': [2114], 'existing': [2116], 'out': [2119, 2822], 'Scholar).Our': [2142], 'initial': [2143], 'observation': [2144], 'site': [2152, 2920], 'pLSMT': [2154, 2182, 2221, 2400, 2503, 2669, 2785, 3009, 3156, 3352, 3720, 3783, 3813, 3885], 'prompted': [2155], 'us': [2156], 'further': [2158, 2294], 'examine': [2159], 'particularly': [2167], 'end,': [2175], 'nonreactive': [2189], 'Sinefungin': [2191, 2279, 3204, 3457, 3496, 3762, 3808, 4095], 'adenosyl-l-ornithine)': [2195], 'AzaAdoMet': [2197, 3234, 3540, 3569, 3760, 3810, 4067], '(see': [2198, 3595], 'Fig.': [2199], '1)': [2200], 'quantified': [2202], 'addition,': [2215], 'report': [2217], '(Me3Lys)': [2225], 'S-adenosyl-l-homocysteine': [2227], '(AdoHcy),': [2228], 'representing': [2229], 'terminal': [2231], 'trimethylation.': [2236], 'furnish': [2244], 'direct': [2245, 3325], 'evidence': [2246], 'yield': [2260], 'mechanistic': [2261], 'functions': [2266], 'PKMTs.EXPERIMENTAL': [2271], 'PROCEDURESChemicals': [2272], 'Reagents—S-Adenosyl-l-methionine,': [2274], 'S-adenosyl-l-homocysteine,': [2275], 'l-lysine': [2276], 'acetate,': [2277], 'were': [2280, 2288, 2401, 2451, 2482, 2508, 2539, 2553, 2678, 2711, 2739, 2760, 2787, 2847, 2906, 2946, 2983, 3248, 3353, 3763], 'purchased': [2281], 'Sigma,': [2283], 'l-ϵ-monomethyllysine': [2285], 'l-ϵ-trimethyllysine': [2287], 'Bachem.': [2291], 'purified': [2295, 2326, 2404], 'anion-exchange': [2297], 'chromatography': [2298], 'previously': [2301, 2407, 2690, 3838], '(39Chirpich': [2302], 'T.P.': [2303], 'Zappia': [2304], 'Costilow': [2306], 'R.N.': [2307], 'Barker': [2308], 'H.A.': [2309], '1970;': [2313], '245:': [2314], '1778-1789Abstract': [2315], 'l-AzaAdoMet': [2322], 'synthesized': [2324], 'according': [2327], 'method': [2330], 'Thompson': [2332], 'et': [2333], 'al.': [2334], '(40Thompson': [2335], 'M.J.': [2336], 'Mekhalfia': [2337], 'Hornby': [2339], 'Org.': [2344], '64:': [2347], '7467-7473Crossref': [2348], '(31)': [2350], 'Scholar).Protein': [2352], 'Cloning,': [2353], 'Expression,': [2354], 'Purification—The': [2356], 'encoding': [2358], 'residues': [2359], '43-477': [2360], 'Arabidopsis': [2362, 2371], 'LSMT': [2365], '(aLSMT)': [2366], 'amplified': [2368], 'cDNA': [2372], 'library': [2373], '(Research': [2374], 'Genetics)': [2375], 'cloned': [2377], 'GATEWAY': [2380], 'vector': [2381], 'pDEST14': [2382], '(Invitrogen)': [2383], 'C-terminal': [2386], 'hexahistidine': [2387], 'tag': [2388], 'tobacco': [2391], 'etch': [2392], 'virus': [2393], 'protease': [2394], 'cleavage': [2395], 'Both': [2397], 'aLSMT': [2398, 3416, 3464, 3489, 3547, 3571, 3605, 3616, 3706], 'overexpressed': [2402], 'After': [2432], 'gel': [2433], 'filtration': [2434], 'purification': [2435], '20': [2437, 2485, 2496], 'mm': [2438, 2443, 2447, 2486, 2493], 'Tris,': [2439], 'pH': [2440, 2489, 2686], '8.0,': [2441], '150': [2442], 'NaCl,': [2444], '10': [2446], 'β-mercaptoethanol,': [2448], 'concentrated': [2452], '∼50': [2454], 'mg/ml,': [2455], 'flash-frozen': [2456, 2733], 'liquid': [2458, 2735], 'nitrogen,': [2459], 'stored': [2461], 'at': [2462, 2495, 2685, 2746, 2751], '-80': [2463], '°C.Isothermal': [2464], 'Titration': [2465], 'Calorimetry—Cofactor': [2466], 'measured': [2469, 2984, 3599], 'using': [2470, 2556, 2764, 2789, 2823, 2851, 2950, 3241, 3378], 'calorimetry': [2473, 3395], '(ITC)': [2474], 'VP-ITC': [2477], 'calorimeter': [2478], '(MicroCal,': [2479], 'LLC).': [2480], 'Experiments': [2481], 'performed': [2483, 2509, 2540], 'sodium': [2487, 2683, 2717], 'phosphate,': [2488], '7.5,': [2490], '100': [2492], 'NaCl': [2494], '°C.': [2497], 'Due': [2498, 3510], 'aggregation': [2501, 3393], 'during': [2504, 3361, 3394], 'experiments': [2507, 3396], 'closely': [2513, 3381], 'related': [2514, 3382], 'ortholog': [2515, 3383], 'overall': [2521], 'identity': [2523], '64%': [2525], '100%': [2532], 'identical': [2533], 'Titrations': [2538], 'concentrations': [2543], 'ligand': [2545, 2566], '(1.0-5.0': [2546], 'mm)': [2547], '(0.1-0.4': [2550], 'μm).': [2551], 'Data': [2552, 2759], 'then': [2554], 'analyzed': [2555], 'Origin': [2557], '7.0': [2558], '(OriginLab': [2559], 'Corp.)': [2560], 'blank': [2562], 'injections': [2563], 'buffer': [2569], 'subtracted': [2570], 'titrations': [2573], 'analysis.': [2577], 'All': [2578], 'calculated': [2581, 2621, 2631, 2652, 2907], 'curves': [2583], 'stoichiometries': [2586], '(N-values)': [2587], '0.8': [2589], '1.0.': [2591], 'Curve': [2592], 'fitting': [2593], 'errors': [2594, 2620, 2630, 2651], 'each': [2596, 2931, 3882], 'experiment': [2598], 'Table': [2602, 2936], '1.TABLE': [2603], '1ITC': [2604], 'analysis': [2605, 3251, 3400], 'aLSMTLigandKDΔHμmkcal/molAdoMet0.29': [2615], '±': [2616, 2626, 2636, 2638, 2640, 2642, 2644, 2646, 3169, 3171, 3173, 3177, 3179, 3181, 3185, 3187, 3189], '0.02aDeviations': [2617], 'curve-fitting': [2619, 2629, 2650], 'isotherms–11.0': [2625], '0.1aDeviations': [2627], 'isothermsSinefungin4.2': [2635], '0.1–8.3': [2637], '0.1AzaAdoMet>1000': [2639], '100<–3.9': [2641], '0.8AdoHcy21.2': [2643], '1.6–14.7': [2645], '0.3a': [2647], 'Deviations': [2648], 'isotherms': [2656], 'Open': [2657, 3137, 3191], 'table': [2658, 3138, 3192], 'new': [2661, 3141, 3195], 'tab': [2662, 3142, 3196], 'Crystallization,': [2663], 'Structure': [2664], 'Determination,': [2665], 'Modeling—Crystals': [2667], 'Sinefungin-MeLys,': [2674], 'AzaAdoMet-lysine,': [2675], 'Me3Lys-AdoHcy': [2677], '0.9-1.7': [2681], 'm': [2682], 'acetate': [2684, 2718], '6.8': [2687], 'Crystals': [2710], 'serially': [2712], 'dehydrated': [2713], 'increasing': [2715], 'concentration': [2719], 'stepwise': [2720], '3.0': [2722], 'm,': [2723], 'harvested': [2724], 'mother': [2726], 'liquor': [2727], 'supplemented': [2728], '15%': [2730], '1,2-propanediol,': [2731], 'nitrogen.': [2736], 'Oscillation': [2737], 'images': [2738], 'collected': [2740], 'Mar165': [2743], 'CCD': [2744], 'detector': [2745], 'COM-CAT': [2748], '32-ID': [2749], 'beamline': [2750], 'Advanced': [2753], 'Photon': [2754], 'Source': [2755], 'Synchrotron,': [2756], 'Argonne,': [2757], 'IL.': [2758], 'integrated': [2761], 'scaled': [2763], 'd*TREK': [2765], '(41Messerschmidt': [2766], 'Pflugrath': [2768], 'J.W.': [2769], 'Appl.': [2771], '1987;': [2773], '20:': [2774], '306-315Crossref': [2775], '(457)': [2777], 'solved': [2788, 3737], 'pLSMT-AdoHcy-lysine': [2791], 'coordinates': [2792], '(1P0Y.pdb)': [2793], 'starting': [2796], 'model': [2797, 2818, 2915, 3045], 'Manual': [2817], 'building': [2819], 'carried': [2821], 'O': [2824], '(42Jones': [2825], 'Zou': [2827], 'J.Y.': [2828], 'Cowan': [2829], 'S.W.': [2830], 'Kjeldgaard': [2831], '47:': [2838], '110-119Crossref': [2839], '(13004)': [2842], 'refined': [2848], 'CNS': [2850], 'default': [2853], 'stereochemical': [2854], 'restraint': [2855], 'parameters': [2856, 3147, 3226], '(43Brunger': [2857], 'A.T.': [2858], 'Adams': [2859], 'P.D.': [2860], 'Clore': [2861], 'DeLano': [2863], 'W.L.': [2864], 'Gros': [2865], 'Grosse-Kunstleve': [2867], 'R.W.': [2868], 'Jiang': [2869], 'Kuszewski': [2871], 'Nilges': [2873], 'Pannu': [2875], 'N.S.': [2876], 'Read': [2877], 'R.J.': [2878], 'Rice': [2879], 'Simonson': [2881], 'Warren': [2883], 'G.L.': [2884], '905-921Crossref': [2893], '(16930)': [2896], 'Simulated': [2899], 'annealing': [2900], 'Fo': [2901], '-': [2902], 'Fc': [2903], 'omit': [2904], 'maps': [2905], 'absence': [2910], 'accurately': [2914], 'them': [2916], 'unbiased': [2923], 'manner.': [2924], 'Crystallographic': [2925], 'refinement': [2928, 3006, 3079], 'statistics': [2929, 3007], 'summarized': [2934], '2.': [2937], 'For': [2938], 'evaluating': [2939], 'parameters,': [2943], 'modeled': [2947], 'onto': [2948], 'PRODRG2': [2951], '(44Schuttelkopf': [2952], 'A.W.': [2953], 'van': [2954], 'Aalten': [2955], '60:': [2964], '1355-1363Crossref': [2965], '(4142)': [2968], 'bond': [2974, 3146, 3693], 'distances': [2975], 'angles': [2977, 3095], 'Swiss-PDB': [2986], 'Viewer': [2987], '(45Guex': [2988], 'Peitsch': [2990], 'M.C.': [2991], 'Electrophoresis.': [2992], '18:': [2994], '2714-2723Crossref': [2995], '(9472)': [2998], '(Table': [3001, 3508], '3).TABLE': [3002], '2Crystallographic': [3003], 'complexesAdoMetSinefungin-MeLysAzaAdoMet-LysAdoHcy-Me3LysCrystal': [3010], 'parametersSpace': [3011], 'groupI222Unit': [3012], '(Å)131.45132.37132.63131.86': [3015], 'b155.86156.50159.49157.55': [3016], 'c263.61267.59268.51267.60': [3017], 'α,': [3018], 'β,': [3019], 'γ': [3020, 3025], '(°)α': [3021], '=': [3022, 3024, 3026, 3051, 3056, 3104, 3109], 'β': [3023], '90Asymmetric': [3027], 'unit3': [3028], 'moleculesData': [3029], 'collection': [3030], 'statisticsResolution': [3031, 3039], 'range': [3032, 3040, 4073, 4146], '(Å)13.0-2.4527.8-2.416.8-2.6015.0-2.45Total': [3033], 'reflections517485356765314052447162Unique': [3034], 'reflections9780710831185610101323Rsym': [3035], '(%)6.54.810.35.6I/σ': [3036], '(I)12.713.77.210.7Completeness': [3037], '(%)99.397.698.299.6Refinement': [3038], '(Å)13.0-2.4527.8-2.4516.7-2.6015.0-2.45Reflections': [3041], '(Fo': [3042], '>': [3043], '2σ)94670965958527099453Final': [3044], 'atoms10483104831048310483': [3047], 'Ligands81114111117': [3048], 'Water559450385390R-factorsaR-factor:': [3049], 'Rworking': [3050, 3103], 'Σ||Fo|': [3052, 3105], '–': [3053, 3058, 3106, 3111], '|Fc||/Σ|Fo|;': [3054, 3107], 'Rfree': [3055, 3108], 'ΣT||Fo|': [3057, 3110], '|Fc||/ΣT|Fo|,': [3059, 3112], 'where': [3060, 3113], 'T': [3061, 3114], 'test': [3064, 3117], '5%': [3068, 3121], 'total': [3071, 3124], 'reflections': [3072, 3125], 'randomly': [3073, 3126], 'chosen': [3074, 3127], 'aside': [3077, 3130], 'before': [3078, 3131], 'Rworking24.825.326.225.3': [3080], 'Rfree28.829.229.828.8Luzzati': [3081], 'coordinate': [3082], 'error': [3083, 3086], '(Å)0.420.420.470.42Cross-validated': [3084], 'LuzzatiCoordinate': [3085], '(Å)0.490.480.510.48r.m.s.br.m.s.,': [3087], 'root': [3088, 3134], 'mean': [3089, 3135], 'square': [3090, 3136], 'Bond': [3091, 3094], 'length': [3092], '(Å)0.0070.0070.0080.008': [3093], '(°)1.21.31.31.2Average': [3096], 'B-factors': [3097], '(Å2)': [3098], 'Protein68.170.971.766.7': [3099], 'Ligands52.558.692.981.3': [3100], 'Water62.063.970.060.2a': [3101], 'R-factor:': [3102], 'refinementb': [3132], 'r.m.s.,': [3133], 'TABLE': [3143], '3CH···O': [3144], 'molecules': [3157, 3831], 'asymmetric': [3160, 3834], 'unitCH···O': [3161], 'H-bond': [3162], 'acceptorMean': [3163], 'dCOMean': [3164], 'dHMean': [3165], 'θÅÅdegreesSer-221': [3166], 'carbonyl': [3167, 3175, 4036, 4077, 4120, 4126], 'oxygen3.2': [3168, 3176], '0.22.3': [3170], '0.2147': [3172], '3Asp-239': [3174], '0.22.4': [3178], '0.2139': [3180], '4Tyr-287': [3182], 'hydroxyl': [3183, 4048, 4085, 4114], 'group3.3': [3184], '0.12.3': [3186], '0.1155': [3188], '4': [3190], 'RESULTSCalorimetric': [3197], 'Analysis': [3198], 'AzaAdoMet,': [3202, 3277, 3724, 4001], 'Binding': [3205], 'aLSMT—To': [3207], 'investigate': [3208], 'different': [3212], 'chemical': [3213, 3255, 3334], 'moieties': [3214, 3256], 'thermodynamic': [3225], 'ITC.': [3242, 3362], 'latter': [3244], 'selected': [3249], 'because': [3252, 3680], 'they': [3253], 'differ': [3258], 'respect': [3260], 'sulfonium': [3266, 3286, 3313, 3554, 3581, 3714], 'cation': [3267, 3555], 'but': [3270], 'otherwise': [3272], 'isosteric': [3273, 3513], '(Fig.': [3274, 3397, 3587, 3911, 4063, 4091, 4140], '1).': [3275, 3509], 'tertiary': [3279, 3585], 'nitrogen': [3280], 'substituted': [3282], 'cation,': [3287, 3314], 'rendering': [3288], 'inert': [3292], 'transfer.': [3294], 'δ-amine': [3298, 3475, 3536, 4099], 'methylene': [3301], 'moiety': [3302], 'incorporated': [3304], 'place': [3306], 'respectively.': [3315, 3772], 'variations': [3318, 3995], 'provide': [3323], 'means': [3326], 'thermodynamically': [3328], 'quantifying': [3329], "enzyme's": [3338], 'Unfortunately,': [3342], 'attempts': [3343], 'measure': [3345], 'unsuccessful': [3354], 'due': [3355, 3465, 3575, 4006], 'propensity': [3358], 'aggregate': [3360], 'circumvent': [3364], 'issue,': [3366], 'equilibrium': [3370], 'dissociation': [3371], 'constants': [3372], '(KD)': [3373], 'enthalpies': [3376], '(ΔH)': [3377], 'not': [3390, 3671, 4005], 'prone': [3391], '2).FIGURE': [3398], '2ITC': [3399], 'aLSMT.': [3405], 'top': [3407], 'panel': [3408, 3429], 'represents': [3409], 'solution': [3417], 'heat': [3420], 'evolved': [3421], '(μcal/s)': [3422], 'plotted': [3423], 'versus': [3424, 3629], 'time': [3425], '(min).': [3426], 'bottom': [3428], 'illustrates': [3430], 'isotherm': [3433], 'fitted': [3436], 'curve.View': [3438], 'Large': [3439], 'Image': [3440], 'Figure': [3441], 'ViewerDownload': [3442], 'Hi-res': [3443], 'image': [3444], 'Download': [3445], '(PPT)Based': [3446], 'knowledge': [3449], 'site,': [3453], 'postulated': [3455], 'would': [3458], 'exhibit': [3459], 'greatest': [3461], 'affinity': [3462, 3494, 3560, 3614, 3997], 'NH···O': [3468, 4109], "ligand's": [3473, 4098], 'primary': [3474], 'comprising': [3480], 'Surprisingly,': [3485], 'binds': [3487, 3541], '14-fold': [3492], 'higher': [3493, 3501], 'than': [3495, 3548], 'exhibits': [3498, 3590, 3610], 'correspondingly': [3500], 'enthalpy': [3502, 3625], 'nature': [3514], 'ligands,': [3517], 'preferentially': [3526], 'interacts': [3527], 'comparison': [3533], 'Sinefungin.': [3538], 'Conversely,': [3539], 'over': [3542], '3000-fold': [3543], 'more': [3544], 'weakly': [3545], 'indicating': [3550], 'essential': [3557], 'high': [3559], 'impaired': [3566], 'most': [3573], 'likely': [3574], 'replacement': [3578], 'amine': [3586, 3901], '1),': [3588], 'pH-dependent': [3592], 'ionization': [3593], 'state': [3594], 'below).': [3596], 'Finally,': [3597], 'AdoHcy': [3603, 3645, 3920], 'observed': [3607], 'it': [3609], '∼70-fold': [3612], 'lower': [3613], 'compared': [3618], 'despite': [3621], 'greater': [3623], 'substrate.': [3631], 'differences': [3633, 4009], 'imply': [3634], 'entropic': [3637, 3674], 'penalty': [3638, 3675], 'involved': [3640], 'association': [3643], 'may': [3650], 'derive': [3651], 'losses': [3653], 'rotational': [3656], 'freedom': [3657], 'along': [3658], 'Cγ-Sδ': [3660], 'Sδ-C5′': [3662], 'upon': [3667], 'binding.': [3668], 'does': [3670], 'incur': [3672], 'same': [3678, 3821], 'degree': [3679], 'presence': [3683], 'Cϵ-methyl': [3686], 'group,': [3687], 'limits': [3689], 'rotation': [3690], 'around': [3691], 'axes.': [3694], 'summary,': [3696], 'cofactor.Structures': [3718], 'Bound': [3721], 'Sinefungin—To': [3726], 'determinants': [3729], 'analogs.': [3749], 'crystallized': [3752, 3818], 'binary': [3755, 3814], 'whereas': [3759, 4124], 'free': [3774], 'amino': [3775], 'acids': [3776], 'serve': [3777], 'minimally': [3779], 'competent': [3780], 'facilitated': [3804], 'crystallization': [3805], 'complexes.': [3811], 'space': [3822], 'similar': [3825], 'unit': [3826], 'dimensions': [3828], 'unit,': [3835], 'Scholar).In': [3881], 'complexes,': [3886], 'adopts': [3889], 'horseshoe-shaped': [3891], 'conformation': [3892], 'pocket,': [3897], 'inserting': [3898], 'either': [3899], '3).': [3912], 'mode': [3915], 'cofactor-bound': [3970], '(46Xiao': [3974], '699-705Crossref': [3986], '(133)': [3989], 'illustrating': [3992], 'exhibited': [3998], 'overt': [4008], 'respective': [4012], 'conformations.': [4014], 'pLSMT-AdoMet': [4017], 'coordinated': [4024], 'short': [4031, 4072, 4145], 'distance': [4032], 'Ser-221': [4039, 4080, 4129], '(3.3': [4040, 4052], 'Å)': [4041, 4045, 4082, 4090, 4134], 'Asp-239': [4043], '(3.0': [4044, 4081, 4089], 'Tyr-287': [4051, 4088, 4117], 'Å),': [4053], 'invariant': [4057], 'residue': [4058], '3A).': [4064], 'Similarly,': [4065], 'engages': [4070], 'contacts': [4074], '3B).': [4092], 'Asp-239,': [4123], 'too': [4131], 'distant': [4132], '(3.6': [4133], '3C).': [4141], 'ascertain': [4143], 'whether': [4144], 'present': [4150], 'examined': [4161], '1.7': [4163], 'Å': [4164], 'resolution': [4165], 'H3': [4170], 'Lys-4-specific': [4171], '(6Kwon': [4177], 'J.H': [4180]}, 'cited_by_api_url': 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