Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2102433483', 'doi': 'https://doi.org/10.1073/pnas.0505473102', 'title': 'Mechanism of radiation-induced bystander effect: Role of the cyclooxygenase-2 signaling pathway', 'display_name': 'Mechanism of radiation-induced bystander effect: Role of the cyclooxygenase-2 signaling pathway', 'publication_year': 2005, 'publication_date': '2005-10-03', 'ids': {'openalex': 'https://openalex.org/W2102433483', 'doi': 'https://doi.org/10.1073/pnas.0505473102', 'mag': '2102433483', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16203985', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1253564'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0505473102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.0505473102', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102103476', 'display_name': 'Hongning Zhou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Hongning Zhou', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091297456', 'display_name': 'Vladimir N. Ivanov', 'orcid': 'https://orcid.org/0000-0003-3091-9774'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Vladimir N. Ivanov', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087358711', 'display_name': 'Joseph J. Gillespie', 'orcid': 'https://orcid.org/0000-0002-5447-7264'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Joseph Gillespie', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013984522', 'display_name': 'Charles R. Geard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Charles R. Geard', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039752024', 'display_name': 'Sally A. Amundson', 'orcid': 'https://orcid.org/0000-0001-9992-8818'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Sally A. Amundson', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048201953', 'display_name': 'David J. Brenner', 'orcid': 'https://orcid.org/0000-0002-0926-1210'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'David J. Brenner', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111722780', 'display_name': 'Zengliang Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Zengliang Yu', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009696243', 'display_name': 'Howard B. Lieberman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Howard B. Lieberman', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I19820366', 'https://openalex.org/I78577930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067197557', 'display_name': 'Tom K. Hei', 'orcid': 'https://orcid.org/0000-0003-3553-1007'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Tom K. Hei', 'raw_affiliation_strings': ['Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, and Key Laboratory of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei 230031, China', 'institution_ids': ['https://openalex.org/I78577930', 'https://openalex.org/I19820366']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.476, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 253, 'citation_normalized_percentile': {'value': 0.999925, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '102', 'issue': '41', 'first_page': '14641', 'last_page': '14646'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11422', 'display_name': 'Burn Injury Management and Outcomes', 'score': 0.9753, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11176', 'display_name': 'Radiation Therapy and Dosimetry', 'score': 0.9464, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bystander-effect', 'display_name': 'Bystander effect', 'score': 0.9906629}, {'id': 'https://openalex.org/keywords/cell-signaling', 'display_name': 'Cell Signaling', 'score': 0.42969602}], 'concepts': [{'id': 'https://openalex.org/C19106626', 'wikidata': 'https://www.wikidata.org/wiki/Q230749', 'display_name': 'Bystander effect', 'level': 2, 'score': 0.9906629}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.67638385}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.6547824}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.5638206}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.5344602}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4737635}, {'id': 'https://openalex.org/C150555746', 'wikidata': 'https://www.wikidata.org/wiki/Q210973', 'display_name': 'Cell signaling', 'level': 3, 'score': 0.42969602}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.42781058}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37886187}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21161947}], 'mesh': [{'descriptor_ui': 'D024201', 'descriptor_name': 'Bystander Effect', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D000512', 'descriptor_name': 'Alpha Particles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024201', 'descriptor_name': 'Bystander Effect', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D024201', 'descriptor_name': 'Bystander Effect', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D024201', 'descriptor_name': 'Bystander Effect', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D052246', 'descriptor_name': 'Cyclooxygenase 2 Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007041', 'descriptor_name': 'Hypoxanthine Phosphoribosyltransferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007041', 'descriptor_name': 'Hypoxanthine Phosphoribosyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009578', 'descriptor_name': 'Nitrobenzenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009578', 'descriptor_name': 'Nitrobenzenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0505473102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1253564', 'pdf_url': 'https://europepmc.org/articles/pmc1253564?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7916/D8VM4BHC', 'pdf_url': 'https://academiccommons.columbia.edu/doi/10.7916/D8W66XGW/download', 'source': {'id': 'https://openalex.org/S4306402601', 'display_name': 'Columbia Academic Commons (Columbia University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I78577930', 'host_organization_name': 'Columbia University', 'host_organization_lineage': ['https://openalex.org/I78577930'], 'host_organization_lineage_names': ['Columbia University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253564', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16203985', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0505473102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.7, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1526797885', 'https://openalex.org/W1906714136', 'https://openalex.org/W1928411162', 'https://openalex.org/W1964419155', 'https://openalex.org/W1968029748', 'https://openalex.org/W1977472414', 'https://openalex.org/W1978538634', 'https://openalex.org/W1980761731', 'https://openalex.org/W1983131031', 'https://openalex.org/W2005900169', 'https://openalex.org/W2012810767', 'https://openalex.org/W2021551701', 'https://openalex.org/W2029224024', 'https://openalex.org/W2040981816', 'https://openalex.org/W2054749775', 'https://openalex.org/W2059795126', 'https://openalex.org/W2060057454', 'https://openalex.org/W2075497030', 'https://openalex.org/W2087870236', 'https://openalex.org/W2101331356', 'https://openalex.org/W2111554139', 'https://openalex.org/W2115350007', 'https://openalex.org/W2118360398', 'https://openalex.org/W2118364944', 'https://openalex.org/W2124484136', 'https://openalex.org/W2132305988', 'https://openalex.org/W2135116572', 'https://openalex.org/W2138297556', 'https://openalex.org/W2144149653', 'https://openalex.org/W2144318283', 'https://openalex.org/W2145846248', 'https://openalex.org/W2146100468', 'https://openalex.org/W2163053669', 'https://openalex.org/W2164856505', 'https://openalex.org/W2167894711', 'https://openalex.org/W2168212159', 'https://openalex.org/W2177155101', 'https://openalex.org/W2257496989', 'https://openalex.org/W4214917868'], 'related_works': ['https://openalex.org/W4281897067', 'https://openalex.org/W3037320846', 'https://openalex.org/W2916357899', 'https://openalex.org/W2410686946', 'https://openalex.org/W2123013129', 'https://openalex.org/W2052131670', 'https://openalex.org/W2047183378', 'https://openalex.org/W2004726042', 'https://openalex.org/W1520436089', 'https://openalex.org/W120438317'], 'abstract_inverted_index': {'The': [0], 'radiation-induced': [1], 'bystander': [2, 34, 86, 133, 137, 148, 178, 193, 218], 'effect': [3], 'is': [4, 64, 158, 204, 211], 'defined': [5], 'as': [6, 54, 121], '“the': [7], 'induction': [8], 'of': [9, 42, 61, 74, 136, 154, 161, 171, 185], 'biological': [10, 43], 'effects': [11, 35], 'in': [12, 25, 45, 55, 84, 105, 131, 191, 206], 'cells': [13, 29, 138], 'that': [14, 30, 115, 169, 199], 'are': [15, 24, 77], 'not': [16, 65], 'directly': [17], 'traversed': [18], 'by': [19], 'a': [20, 40, 108], 'charged': [21, 102], 'particle': [22, 103], 'but': [23], 'close': [26], 'proximity': [27], 'to': [28, 80, 94], 'are.”': [31], 'Although': [32, 67], 'these': [33], 'have': [36, 92], 'been': [37], 'demonstrated': [38], 'with': [39, 107, 139], 'variety': [41], 'endpoints': [44], 'both': [46, 78], 'human': [47], 'and': [48, 71], 'rodent': [49], 'cell': [50], 'lines': [51], '(as': [52], 'well': [53], '3D': [56], 'tissue': [57], 'samples),': [58], 'the': [59, 62, 72, 85, 88, 99, 116, 132, 147, 151, 155, 159, 162, 172, 182, 192, 200, 212, 217], 'mechanism': [60], 'phenomenon': [63], 'known.': [66], 'gap': [68], 'junction': [69], 'communication': [70], 'presence': [73], 'soluble': [75], 'mediator(s)': [76], 'known': [79, 120], 'play': [81], 'important': [82, 183], 'roles': [83], 'response,': [87, 210], 'precise': [89], 'signaling': [90, 125, 157, 189, 214], 'molecules': [91], 'yet': [93], 'be': [95], 'identified.': [96], 'By': [97], 'using': [98], 'Columbia': [100], 'University': [101], 'beam': [104], 'conjunction': [106], 'strip': [109], 'dish': [110], 'design,': [111], 'we': [112], 'show': [113], 'here': [114], 'cyclooxygenase-2': [117], '(COX-2,': [118], 'also': [119], 'prostaglandin': [122], 'endoperoxide': [123], 'synthase-2)': [124], 'cascade': [126, 190], 'plays': [127], 'an': [128], 'essential': [129, 205], 'role': [130, 184], 'process.': [134, 194], 'Treatment': [135], 'NS-398,': [140], 'which': [141, 203], 'suppresses': [142], 'COX-2': [143, 156], 'activity,': [144], 'significantly': [145], 'reduced': [146], 'effect.': [149], 'Because': [150], 'critical': [152, 213], 'event': [153], 'activation': [160], 'mitogen-activated': [163, 186], 'protein': [164, 187], 'kinase': [165, 175, 188], 'pathways,': [166], 'our': [167], 'finding': [168], 'inhibition': [170], 'extracellular': [173], 'signal-related': [174], 'phosphorylation': [176], 'suppressed': [177], 'response': [179], 'further': [180], 'confirmed': [181], 'These': [195], 'results': [196], 'provide': [197], 'evidence': [198], 'COX-2-related': [201], 'pathway,': [202], 'mediating': [207], 'cellular': [208], 'inflammatory': [209], 'link': [215], 'for': [216], 'phenomenon.': [219]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2102433483', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 27}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-08T19:54:45.035080', 'created_date': '2016-06-24'}