Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2102407394', 'doi': 'https://doi.org/10.1161/01.res.24.5.725', 'title': 'Increased Myocardial Oxygen Consumption and Contractile State Associated with Increased Heart Rate in Dogs', 'display_name': 'Increased Myocardial Oxygen Consumption and Contractile State Associated with Increased Heart Rate in Dogs', 'publication_year': 1969, 'publication_date': '1969-05-01', 'ids': {'openalex': 'https://openalex.org/W2102407394', 'doi': 'https://doi.org/10.1161/01.res.24.5.725', 'mag': '2102407394', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/5770259'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.res.24.5.725', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.RES.24.5.725', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.RES.24.5.725', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028330096', 'display_name': 'Robert C. Boerth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'ROBERT C. BOERTH', 'raw_affiliation_strings': ['Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014', 'institution_ids': ['https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109143213', 'display_name': 'James W. Covell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'JAMES W. COVELL', 'raw_affiliation_strings': ['Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014', 'institution_ids': ['https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108432824', 'display_name': 'Peter E. Pool', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'PETER E. POOL', 'raw_affiliation_strings': ['Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014', 'institution_ids': ['https://openalex.org/I4210106489']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110143992', 'display_name': 'John Ross', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'JOHN ROSS', 'raw_affiliation_strings': ['Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014', 'institution_ids': ['https://openalex.org/I4210106489']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.912, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 130, 'citation_normalized_percentile': {'value': 0.987679, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '24', 'issue': '5', 'first_page': '725', 'last_page': '734'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10821', 'display_name': 'Cardiovascular Function and Risk Factors', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11922', 'display_name': 'Cardiovascular Effects of Exercise', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/beat', 'display_name': 'Beat (acoustics)', 'score': 0.6067306}], 'concepts': [{'id': 'https://openalex.org/C2777953023', 'wikidata': 'https://www.wikidata.org/wiki/Q1073121', 'display_name': 'Heart rate', 'level': 3, 'score': 0.75777227}, {'id': 'https://openalex.org/C540031477', 'wikidata': 'https://www.wikidata.org/wiki/Q629', 'display_name': 'Oxygen', 'level': 2, 'score': 0.75438917}, {'id': 'https://openalex.org/C189809214', 'wikidata': 'https://www.wikidata.org/wiki/Q829522', 'display_name': 'Beat (acoustics)', 'level': 2, 'score': 0.6067306}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6052122}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.5116058}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41598368}, {'id': 'https://openalex.org/C163415756', 'wikidata': 'https://www.wikidata.org/wiki/Q126473', 'display_name': 'Contraction (grammar)', 'level': 2, 'score': 0.41430932}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3468249}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33220232}, {'id': 'https://openalex.org/C140793950', 'wikidata': 'https://www.wikidata.org/wiki/Q168091', 'display_name': 'Animal science', 'level': 1, 'score': 0.32772946}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19159651}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.1507647}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C24890656', 'wikidata': 'https://www.wikidata.org/wiki/Q82811', 'display_name': 'Acoustics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D006339', 'descriptor_name': 'Heart Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004562', 'descriptor_name': 'Electrocardiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009929', 'descriptor_name': 'Organ Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010101', 'descriptor_name': 'Oxygen Consumption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.res.24.5.725', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.RES.24.5.725', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/5770259', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.res.24.5.725', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.RES.24.5.725', 'source': {'id': 'https://openalex.org/S10652568', 'display_name': 'Circulation Research', 'issn_l': '0009-7330', 'issn': ['0009-7330', '1524-4571'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1615932296', 'https://openalex.org/W1980538753', 'https://openalex.org/W2004275491', 'https://openalex.org/W2007596664', 'https://openalex.org/W2009501851', 'https://openalex.org/W2080174053', 'https://openalex.org/W2099086698', 'https://openalex.org/W2122702924', 'https://openalex.org/W2125645419', 'https://openalex.org/W2135554589', 'https://openalex.org/W2137349320', 'https://openalex.org/W2255059864', 'https://openalex.org/W2270287237', 'https://openalex.org/W2281774636', 'https://openalex.org/W2285753278', 'https://openalex.org/W2331786365', 'https://openalex.org/W2335872846', 'https://openalex.org/W2398081328', 'https://openalex.org/W2408076159', 'https://openalex.org/W2464206785'], 'related_works': ['https://openalex.org/W653810948', 'https://openalex.org/W4205930110', 'https://openalex.org/W2363341327', 'https://openalex.org/W2090102624', 'https://openalex.org/W2065025653', 'https://openalex.org/W2009462014', 'https://openalex.org/W1981155105', 'https://openalex.org/W1965229134', 'https://openalex.org/W1536684843', 'https://openalex.org/W1490229056'], 'abstract_inverted_index': {'The': [0, 172], 'effects': [1, 65], 'of': [2, 6, 41, 66, 104, 107, 162, 191], 'increasing': [3, 169], 'the': [4, 64, 105, 151, 158, 176, 198], 'frequency': [5], 'contraction': [7], 'on': [8, 69], 'myocardial': [9], 'oxygen': [10, 70, 121, 127, 133, 142], 'consumption': [11, 71, 93, 122, 128, 143], 'per': [12, 72, 94, 123, 144, 203], 'minute': [13], '(MV': [14], '·': [15, 31, 88, 179], 'o': [16, 32, 89], '2': [17, 33, 90, 181], ')': [18], 'were': [19], 'examined': [20], 'in': [21, 44, 53, 59, 86, 120, 141, 200], 'eight': [22], 'dogs': [23], 'using': [24], 'an': [25], 'isovolumic': [26], 'left': [27], 'ventricular': [28], 'preparation.': [29], 'MV': [30, 87], 'was': [34, 50, 77, 80, 96, 116, 129, 136, 165], 'determined': [35], 'at': [36, 157], 'two': [37], 'to': [38, 98, 189, 197], 'four': [39], 'levels': [40], 'heart': [42, 67, 75, 108, 112, 170, 185], 'rate': [43, 68, 76, 113, 186], 'each': [45, 54], 'animal.': [46], 'Peak': [47], 'wall': [48, 163], 'stress': [49, 201], 'maintained': [51], 'constant': [52], 'animal': [55], 'so': [56], 'that': [57, 175], 'changes': [58], 'it': [60], 'would': [61], 'not': [62], 'influence': [63], 'beat.': [73, 145], 'As': [74], 'increased,': [78], 'there': [79, 115, 135], 'a': [81, 100, 117, 137], 'highly': [82], 'significant': [83, 118], 'linear': [84, 102], 'increase': [85, 119, 140, 199], '.': [91], 'Oxygen': [92], 'beat': [95], 'shown': [97], 'be': [99], 'negative': [101], 'function': [103], 'reciprocal': [106], 'rate.': [109, 171], 'Thus,': [110], 'as': [111, 150, 194, 196], 'increased': [114, 167, 177], 'beat;': [124], 'when': [125], 'basal': [126], 'subtracted': [130], 'from': [131], 'total': [132], 'consumption,': [134], 'much': [138], 'larger': [139], 'Myocardial': [146], 'contractile': [147, 154, 192], 'state,': [148, 193], 'defined': [149], 'maximum': [152], 'observed': [153], 'element': [155], 'velocity': [156], 'lowest': [159], 'common': [160], 'level': [161], 'stress,': [164], 'significantly': [166], 'by': [168], 'data': [173], 'suggest': [174], 'M': [178], 'Vo': [180], 'associated': [182], 'with': [183], 'augmented': [184], 'is': [187], 'secondary': [188], 'augmentation': [190], 'well': [195], 'development': [202], 'minute.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2102407394', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-06T03:31:26.055059', 'created_date': '2016-06-24'}