Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2101740186', 'doi': 'https://doi.org/10.1016/j.ijpharm.2006.07.048', 'title': 'Study of a Pingyangmycin delivery system: Zein/Zein–SAIB in situ gels', 'display_name': 'Study of a Pingyangmycin delivery system: Zein/Zein–SAIB in situ gels', 'publication_year': 2007, 'publication_date': '2007-01-02', 'ids': {'openalex': 'https://openalex.org/W2101740186', 'doi': 'https://doi.org/10.1016/j.ijpharm.2006.07.048', 'mag': '2101740186', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16939703'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ijpharm.2006.07.048', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131016564', 'display_name': 'International Journal of Pharmaceutics', 'issn_l': '0378-5173', 'issn': ['0378-5173', '1873-3476'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100634509', 'display_name': 'Zibin Gao', 'orcid': 'https://orcid.org/0000-0003-3506-084X'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zibin Gao', 'raw_affiliation_strings': ['Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017747736', 'display_name': 'Pingtian Ding', 'orcid': 'https://orcid.org/0000-0002-3172-8454'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Pingtian Ding', 'raw_affiliation_strings': ['Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100425506', 'display_name': 'Li Zhang', 'orcid': 'https://orcid.org/0000-0002-0845-0052'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li Zhang', 'raw_affiliation_strings': ['New Drug Research and Development Center, North China Pharmaceutical Group Corporation, Heping East Road 388, Shijiazhuang 050015, PR China'], 'affiliations': [{'raw_affiliation_string': 'New Drug Research and Development Center, North China Pharmaceutical Group Corporation, Heping East Road 388, Shijiazhuang 050015, PR China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101725171', 'display_name': 'Jian Shi', 'orcid': 'https://orcid.org/0000-0002-0110-8908'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Shi', 'raw_affiliation_strings': ['Department of Medical Oncology, The Forth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang 050011, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, The Forth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang 050011, PR China', 'institution_ids': ['https://openalex.org/I111381250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053205806', 'display_name': 'Shuqin Yuan', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuqin Yuan', 'raw_affiliation_strings': ['Benyuan Nano-Instruments Corporation Ltd., Xianliezhong Road 100, Guangzhou 510070, PR China'], 'affiliations': [{'raw_affiliation_string': 'Benyuan Nano-Instruments Corporation Ltd., Xianliezhong Road 100, Guangzhou 510070, PR China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055587105', 'display_name': 'Jing Wei', 'orcid': 'https://orcid.org/0000-0002-2371-6111'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Wei', 'raw_affiliation_strings': ['Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100696773', 'display_name': 'Dawei Chen', 'orcid': 'https://orcid.org/0000-0002-1079-775X'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dawei Chen', 'raw_affiliation_strings': ['Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China', 'institution_ids': ['https://openalex.org/I103890011']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4190, 'currency': 'USD', 'value_usd': 4190, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.671, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.965368, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '328', 'issue': '1', 'first_page': '57', 'last_page': '64'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10980', 'display_name': 'Classification and Treatment of Vascular Anomalies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10980', 'display_name': 'Classification and Treatment of Vascular Anomalies', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11402', 'display_name': 'Management of Vascular Malformations in the Brain', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10641', 'display_name': 'Management of Vascular Access in Healthcare', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/3604', 'display_name': 'Emergency Medical Services'}, 'field': {'id': 'https://openalex.org/fields/36', 'display_name': 'Health Professions'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pingyangmycin', 'display_name': 'Pingyangmycin', 'score': 0.83540463}, {'id': 'https://openalex.org/keywords/endovascular-treatment', 'display_name': 'Endovascular Treatment', 'score': 0.431195}], 'concepts': [{'id': 'https://openalex.org/C2777556447', 'wikidata': 'https://www.wikidata.org/wiki/Q27147663', 'display_name': 'Pingyangmycin', 'level': 3, 'score': 0.83540463}, {'id': 'https://openalex.org/C2777822432', 'wikidata': 'https://www.wikidata.org/wiki/Q216681', 'display_name': 'In situ', 'level': 2, 'score': 0.76930106}, {'id': 'https://openalex.org/C2779820397', 'wikidata': 'https://www.wikidata.org/wiki/Q1392806', 'display_name': 'Drug delivery', 'level': 2, 'score': 0.5343356}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.5222188}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4584652}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.35196292}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24492574}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1698797}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.16483209}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0776788}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.07745579}, {'id': 'https://openalex.org/C2780191036', 'wikidata': 'https://www.wikidata.org/wiki/Q861028', 'display_name': 'Hemangioma', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001761', 'descriptor_name': 'Bleomycin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D013395', 'descriptor_name': 'Sucrose', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D015028', 'descriptor_name': 'Zein', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001761', 'descriptor_name': 'Bleomycin', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D001761', 'descriptor_name': 'Bleomycin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001761', 'descriptor_name': 'Bleomycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005079', 'descriptor_name': 'Excipients', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005782', 'descriptor_name': 'Gels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018625', 'descriptor_name': 'Microscopy, Atomic Force', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008855', 'descriptor_name': 'Microscopy, Electron, Scanning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010316', 'descriptor_name': 'Particle Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013395', 'descriptor_name': 'Sucrose', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013395', 'descriptor_name': 'Sucrose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014783', 'descriptor_name': 'Viscosity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015028', 'descriptor_name': 'Zein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ijpharm.2006.07.048', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131016564', 'display_name': 'International Journal of Pharmaceutics', 'issn_l': '0378-5173', 'issn': ['0378-5173', '1873-3476'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16939703', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.78, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1640380909', 'https://openalex.org/W1827985050', 'https://openalex.org/W1971793339', 'https://openalex.org/W1972810259', 'https://openalex.org/W1982208056', 'https://openalex.org/W1990240368', 'https://openalex.org/W1993637574', 'https://openalex.org/W1993705924', 'https://openalex.org/W2014532440', 'https://openalex.org/W2019795361', 'https://openalex.org/W2032023825', 'https://openalex.org/W2034976202', 'https://openalex.org/W2035931351', 'https://openalex.org/W2038200800', 'https://openalex.org/W2046546864', 'https://openalex.org/W2058440832', 'https://openalex.org/W2062268963', 'https://openalex.org/W2096350954', 'https://openalex.org/W2134597205', 'https://openalex.org/W2350730793', 'https://openalex.org/W2356516116', 'https://openalex.org/W2477306932', 'https://openalex.org/W29150493'], 'related_works': ['https://openalex.org/W2390411622', 'https://openalex.org/W2385989285', 'https://openalex.org/W2383925283', 'https://openalex.org/W2375704091', 'https://openalex.org/W2367693158', 'https://openalex.org/W2362751008', 'https://openalex.org/W2361629202', 'https://openalex.org/W2360637127', 'https://openalex.org/W2355012111', 'https://openalex.org/W2354106127'], 'abstract_inverted_index': {'Venous': [0], 'malformations': [1], '(VM)': [2], 'are': [3], 'common': [4], 'vascular': [5], 'abnormality,': [6], 'and': [7, 47, 60, 77, 103, 121, 127], 'their': [8], 'management': [9], 'remains': [10], 'difficult.': [11], 'Pingyangmycin': [12], 'hydrochloride': [13], '(PYM)': [14], 'is': [15], 'a': [16, 32], 'useful': [17], 'sclerosant': [18], 'to': [19, 27, 75, 110], 'treat': [20], 'venous': [21], 'malformations.': [22], 'This': [23], 'study': [24], 'was': [25, 55], 'aimed': [26], 'evaluate': [28], 'the': [29, 49, 67, 86, 92, 111, 128], 'effect': [30], 'of': [31, 52, 64, 89, 130], 'new': [33], 'drug': [34, 104], 'delivery': [35], 'system,': [36], 'PYM-loaded': [37], 'Zein/Zein–sucrose': [38], 'acetate': [39], 'isobutyrate': [40], '(SAIB)': [41], 'in': [42, 45, 58, 61, 68, 93, 131], 'situ': [43, 69, 94, 132], 'gels,': [44], 'gelling': [46], 'extending': [48], 'local': [50], 'release': [51, 63, 105], 'PYM.': [53], 'It': [54], 'demonstrated': [56], 'that': [57], 'vitro': [59], 'vivo': [62], 'PYM': [65, 90], 'from': [66, 91], 'gels': [70, 95], 'could': [71, 82], 'be': [72], 'extended': [73], 'up': [74], '7': [76], '4': [78], 'days,': [79], 'respectively.': [80], 'SAIB': [81], 'significantly': [83], 'cut': [84], 'down': [85], 'initial': [87], 'burst': [88], '(P': [96], '<': [97], '0.05).': [98], 'The': [99, 123], 'possible': [100], 'gel': [101, 124, 133], 'forming': [102, 125], 'mechanisms': [106], 'were': [107, 135], 'described': [108], 'according': [109], 'morphology': [112], 'analysis': [113], 'by': [114], 'atomic': [115], 'force': [116], 'microscopy': [117, 120], '(AFM),': [118], 'optical': [119], 'SEM.': [122], 'efficacy': [126], 'viscosity': [129], 'solutions': [134], 'satisfying.': [136]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2101740186', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-08-15T01:36:45.663061', 'created_date': '2016-06-24'}