Publication Information

{'id': 'https://openalex.org/W2101694285', 'doi': 'https://doi.org/10.18632/oncotarget.802', 'title': 'Advances in Targeting Signal Transduction Pathways', 'display_name': 'Advances in Targeting Signal Transduction Pathways', 'publication_year': 2012, 'publication_date': '2012-12-30', 'ids': {'openalex': 'https://openalex.org/W2101694285', 'doi': 'https://doi.org/10.18632/oncotarget.802', 'mag': '2101694285', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23455493', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3681490'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.802', 'pdf_url': 'https://www.oncotarget.com/article/802/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.oncotarget.com/article/802/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030391285', 'display_name': 'James A. McCubrey', 'orcid': 'https://orcid.org/0000-0001-6027-3156'}, 'institutions': [{'id': 'https://openalex.org/I186335123', 'display_name': 'East Carolina University', 'ror': 'https://ror.org/01vx35703', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I186335123']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James A. McCubrey', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University', 'institution_ids': ['https://openalex.org/I186335123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113837598', 'display_name': 'Linda S. Steelman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186335123', 'display_name': 'East Carolina University', 'ror': 'https://ror.org/01vx35703', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I186335123']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Linda S. Steelman', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University', 'institution_ids': ['https://openalex.org/I186335123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004270101', 'display_name': 'William H. Chappell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186335123', 'display_name': 'East Carolina University', 'ror': 'https://ror.org/01vx35703', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I186335123']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William H. Chappell', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University', 'institution_ids': ['https://openalex.org/I186335123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100699934', 'display_name': 'Lin Sun', 'orcid': 'https://orcid.org/0000-0002-8911-1596'}, 'institutions': [{'id': 'https://openalex.org/I186335123', 'display_name': 'East Carolina University', 'ror': 'https://ror.org/01vx35703', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I186335123']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lin Sun', 'raw_affiliation_strings': ['Department of Communication Sciences and Disorders, College of Allied Health Sciences, East Carolina University, Greenville, North Carolina, USA', 'Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University', 'institution_ids': ['https://openalex.org/I186335123']}, {'raw_affiliation_string': 'Department of Communication Sciences and Disorders, College of Allied Health Sciences, East Carolina University, Greenville, North Carolina, USA', 'institution_ids': ['https://openalex.org/I186335123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059966547', 'display_name': 'Nicole D. Armstrong', 'orcid': 'https://orcid.org/0000-0002-6483-4560'}, 'institutions': [{'id': 'https://openalex.org/I186335123', 'display_name': 'East Carolina University', 'ror': 'https://ror.org/01vx35703', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I186335123']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicole M. Davis', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University', 'institution_ids': ['https://openalex.org/I186335123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010041881', 'display_name': 'Stephen L. Abrams', 'orcid': 'https://orcid.org/0000-0003-2326-6672'}, 'institutions': [{'id': 'https://openalex.org/I186335123', 'display_name': 'East Carolina University', 'ror': 'https://ror.org/01vx35703', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I186335123']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen L. Abrams', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University', 'institution_ids': ['https://openalex.org/I186335123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032427069', 'display_name': 'Richard A. Franklin', 'orcid': 'https://orcid.org/0000-0003-0299-9578'}, 'institutions': [{'id': 'https://openalex.org/I186335123', 'display_name': 'East Carolina University', 'ror': 'https://ror.org/01vx35703', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I186335123']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard A. Franklin', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University', 'institution_ids': ['https://openalex.org/I186335123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019461184', 'display_name': 'Lucio Cocco', 'orcid': 'https://orcid.org/0000-0002-9206-8277'}, 'institutions': [{'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lucio Cocco', 'raw_affiliation_strings': ['Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I9360294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020869000', 'display_name': 'Camilla Evangelisti', 'orcid': 'https://orcid.org/0000-0003-3531-9540'}, 'institutions': [{'id': 'https://openalex.org/I4210155236', 'display_name': 'National Research Council', 'ror': 'https://ror.org/04zaypm56', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Camilla Evangelisti', 'raw_affiliation_strings': ['Institute of Molecular Genetics, National Research Council-IOR, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Molecular Genetics, National Research Council-IOR, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210155236']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058584326', 'display_name': 'Francesca Chiarini', 'orcid': 'https://orcid.org/0000-0002-4568-3189'}, 'institutions': [{'id': 'https://openalex.org/I4210155236', 'display_name': 'National Research Council', 'ror': 'https://ror.org/04zaypm56', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Chiarini', 'raw_affiliation_strings': ['Institute of Molecular Genetics, National Research Council-IOR, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Molecular Genetics, National Research Council-IOR, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210155236']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037164805', 'display_name': 'Alberto M. Martelli', 'orcid': 'https://orcid.org/0000-0001-5196-7260'}, 'institutions': [{'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}, {'id': 'https://openalex.org/I4210155236', 'display_name': 'National Research Council', 'ror': 'https://ror.org/04zaypm56', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alberto M. Martelli', 'raw_affiliation_strings': ['Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy', 'Institute of Molecular Genetics, National Research Council-IOR, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I9360294']}, {'raw_affiliation_string': 'Institute of Molecular Genetics, National Research Council-IOR, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210155236']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015437100', 'display_name': 'Massimo Libra', 'orcid': 'https://orcid.org/0000-0002-7232-7737'}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Massimo Libra', 'raw_affiliation_strings': ['Department of Bio-Medical Sciences, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Bio-Medical Sciences, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076971405', 'display_name': 'Saverio Candido', 'orcid': 'https://orcid.org/0000-0003-1255-6666'}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Saverio Candido', 'raw_affiliation_strings': ['Department of Bio-Medical Sciences, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Bio-Medical Sciences, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014498917', 'display_name': 'Giovanni Ligresti', 'orcid': 'https://orcid.org/0000-0002-3375-8665'}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanni Ligresti', 'raw_affiliation_strings': ['Department of Bio-Medical Sciences, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Bio-Medical Sciences, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039656353', 'display_name': 'Grazia Malaponte', 'orcid': 'https://orcid.org/0000-0001-6595-1198'}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Grazia Malaponte', 'raw_affiliation_strings': ['Department of Bio-Medical Sciences, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Bio-Medical Sciences, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037715720', 'display_name': 'María Clorinda Mazzarino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maria C. Mazzarino', 'raw_affiliation_strings': ['Department of Bio-Medical Sciences, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Bio-Medical Sciences, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018957190', 'display_name': 'Paolo Fagone', 'orcid': 'https://orcid.org/0000-0002-6694-1992'}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paolo Fagone', 'raw_affiliation_strings': ['Department of Bio-Medical Sciences, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Bio-Medical Sciences, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025825017', 'display_name': 'Marco Donia', 'orcid': 'https://orcid.org/0000-0003-4966-9752'}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Donia', 'raw_affiliation_strings': ['Department of Bio-Medical Sciences, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Bio-Medical Sciences, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105878418', 'display_name': 'Ferdinando Nicoletti', 'orcid': 'https://orcid.org/0000-0002-4570-8462'}, 'institutions': [{'id': 'https://openalex.org/I39063666', 'display_name': 'University of Catania', 'ror': 'https://ror.org/03a64bh57', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39063666']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ferdinando Nicoletti', 'raw_affiliation_strings': ['Department of Bio-Medical Sciences, University of Catania, Catania, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Bio-Medical Sciences, University of Catania, Catania, Italy', 'institution_ids': ['https://openalex.org/I39063666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090745215', 'display_name': 'Jerry Polesel', 'orcid': 'https://orcid.org/0000-0001-9381-1520'}, 'institutions': [{'id': 'https://openalex.org/I4210128630', 'display_name': 'Centro di Riferimento Oncologico', 'ror': 'https://ror.org/03ks1vk59', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128630', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Jerry Polesel', 'raw_affiliation_strings': ['Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy', 'institution_ids': ['https://openalex.org/I4210128630', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107640573', 'display_name': 'Renato Talamini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128630', 'display_name': 'Centro di Riferimento Oncologico', 'ror': 'https://ror.org/03ks1vk59', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128630', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Renato Talamini', 'raw_affiliation_strings': ['Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy', 'institution_ids': ['https://openalex.org/I4210128630', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004269669', 'display_name': 'Jörg Bäsecke', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74656192', 'display_name': 'University of Göttingen', 'ror': 'https://ror.org/01y9bpm73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I74656192']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jörg Bäsecke', 'raw_affiliation_strings': ['Department of Medicine, University of Göttingen, Göttingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Göttingen, Göttingen, Germany', 'institution_ids': ['https://openalex.org/I74656192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042877486', 'display_name': 'Sanja Mijatović', 'orcid': 'https://orcid.org/0000-0001-9509-9098'}, 'institutions': [{'id': 'https://openalex.org/I4068193', 'display_name': 'University of Belgrade', 'ror': 'https://ror.org/02qsmb048', 'country_code': 'RS', 'type': 'education', 'lineage': ['https://openalex.org/I4068193']}], 'countries': ['RS'], 'is_corresponding': False, 'raw_author_name': 'Sanja Mijatovic', 'raw_affiliation_strings': ['Department of Immunology, Instititue for Biological Research “Sinisa Stankovic”, University of Belgrade, Belgrade, Serbia'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Instititue for Biological Research “Sinisa Stankovic”, University of Belgrade, Belgrade, Serbia', 'institution_ids': ['https://openalex.org/I4068193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090835364', 'display_name': 'Danijela Maksimović‐Ivanić', 'orcid': 'https://orcid.org/0000-0002-8006-5079'}, 'institutions': [{'id': 'https://openalex.org/I4068193', 'display_name': 'University of Belgrade', 'ror': 'https://ror.org/02qsmb048', 'country_code': 'RS', 'type': 'education', 'lineage': ['https://openalex.org/I4068193']}], 'countries': ['RS'], 'is_corresponding': False, 'raw_author_name': 'Danijela Maksimovic-Ivanic', 'raw_affiliation_strings': ['Department of Immunology, Instititue for Biological Research “Sinisa Stankovic”, University of Belgrade, Belgrade, Serbia'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Instititue for Biological Research “Sinisa Stankovic”, University of Belgrade, Belgrade, Serbia', 'institution_ids': ['https://openalex.org/I4068193']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023848359', 'display_name': 'Michèle Milella', 'orcid': 'https://orcid.org/0000-0002-3826-5237'}, 'institutions': [{'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210137471', 'display_name': 'Istituti Fisioterapici Ospitalieri', 'ror': 'https://ror.org/04j6jb515', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210137471', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Michele Milella', 'raw_affiliation_strings': ['IRCCS Istituti fisioterapici ospitalieri - Istituto Regina Elena'], 'affiliations': [{'raw_affiliation_string': 'IRCCS Istituti fisioterapici ospitalieri - Istituto Regina Elena', 'institution_ids': ['https://openalex.org/I4210153126', 'https://openalex.org/I4210137471']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000262370', 'display_name': 'Agostino Tafuri', 'orcid': 'https://orcid.org/0000-0001-7911-9263'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Agostino Tafuri', 'raw_affiliation_strings': ['Sapienza, University of Rome, Department of Cellular Biotechnology and Hematology, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Sapienza, University of Rome, Department of Cellular Biotechnology and Hematology, Rome, Italy', 'institution_ids': ['https://openalex.org/I861853513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083978970', 'display_name': 'Joanna Dulińska-Litewka', 'orcid': 'https://orcid.org/0000-0002-6376-496X'}, 'institutions': [{'id': 'https://openalex.org/I126596746', 'display_name': 'Jagiellonian University', 'ror': 'https://ror.org/03bqmcz70', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I126596746']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Joanna Dulińska-Litewka', 'raw_affiliation_strings': ['Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland'], 'affiliations': [{'raw_affiliation_string': 'Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland', 'institution_ids': ['https://openalex.org/I126596746']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057799391', 'display_name': 'Piotr Laidler', 'orcid': 'https://orcid.org/0000-0002-9190-1220'}, 'institutions': [{'id': 'https://openalex.org/I126596746', 'display_name': 'Jagiellonian University', 'ror': 'https://ror.org/03bqmcz70', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I126596746']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Piotr Laidler', 'raw_affiliation_strings': ['Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland'], 'affiliations': [{'raw_affiliation_string': 'Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland', 'institution_ids': ['https://openalex.org/I126596746']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032990842', 'display_name': 'Antonio B. D’Assoro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Antonio B. D’Assoro', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058661243', 'display_name': 'Л. Б. Дробот', 'orcid': 'https://orcid.org/0000-0002-3711-2909'}, 'institutions': [{'id': 'https://openalex.org/I4210148994', 'display_name': 'Palladin Institute of Biochemistry', 'ror': 'https://ror.org/05hatwc22', 'country_code': 'UA', 'type': 'facility', 'lineage': ['https://openalex.org/I149851306', 'https://openalex.org/I4210148994']}, {'id': 'https://openalex.org/I149851306', 'display_name': 'National Academy of Sciences of Ukraine', 'ror': 'https://ror.org/00je4t102', 'country_code': 'UA', 'type': 'government', 'lineage': ['https://openalex.org/I149851306']}], 'countries': ['UA'], 'is_corresponding': False, 'raw_author_name': 'Lyudmyla Drobot', 'raw_affiliation_strings': ['Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine'], 'affiliations': [{'raw_affiliation_string': 'Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine', 'institution_ids': ['https://openalex.org/I4210148994', 'https://openalex.org/I149851306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068027963', 'display_name': 'Kazuo Umezawa', 'orcid': 'https://orcid.org/0000-0001-9235-4874'}, 'institutions': [{'id': 'https://openalex.org/I16528096', 'display_name': 'Aichi Medical University', 'ror': 'https://ror.org/02h6cs343', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I16528096']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuo Umezawa', 'raw_affiliation_strings': ['AICHI MEDICAL UNIVERSITY', 'Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan'], 'affiliations': [{'raw_affiliation_string': 'AICHI MEDICAL UNIVERSITY', 'institution_ids': ['https://openalex.org/I16528096']}, {'raw_affiliation_string': 'Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan', 'institution_ids': ['https://openalex.org/I16528096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082733849', 'display_name': 'Giuseppe Montalto', 'orcid': 'https://orcid.org/0000-0002-8731-8577'}, 'institutions': [{'id': 'https://openalex.org/I900890020', 'display_name': 'University of Palermo', 'ror': 'https://ror.org/044k9ta02', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I900890020']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Montalto', 'raw_affiliation_strings': ['Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy'], 'affiliations': [{'raw_affiliation_string': 'Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy', 'institution_ids': ['https://openalex.org/I900890020']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070243247', 'display_name': 'Melchiorre Cervello', 'orcid': 'https://orcid.org/0000-0003-4923-7220'}, 'institutions': [{'id': 'https://openalex.org/I4210155236', 'display_name': 'National Research Council', 'ror': 'https://ror.org/04zaypm56', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I4210105756', 'display_name': 'Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy', 'ror': 'https://ror.org/01dy2q607', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210105756', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Melchiorre Cervello', 'raw_affiliation_strings': ['Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare “Alberto Monroy”, Palermo, Italy'], 'affiliations': [{'raw_affiliation_string': 'Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare “Alberto Monroy”, Palermo, Italy', 'institution_ids': ['https://openalex.org/I4210155236', 'https://openalex.org/I4210105756']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087207105', 'display_name': 'Zoya N. Demidenko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1292894508', 'display_name': 'Roswell Park Comprehensive Cancer Center', 'ror': 'https://ror.org/0499dwk57', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1292894508']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zoya N. Demidenko', 'raw_affiliation_strings': ['Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA', 'institution_ids': ['https://openalex.org/I1292894508']}]}], 'institution_assertions': [], 'countries_distinct_count': 7, 'institutions_distinct_count': 18, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.774, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.515457, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '3', 'issue': '12', 'first_page': '1505', 'last_page': '1521'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transduction', 'display_name': 'Transduction (biophysics)', 'score': 0.4713399}, {'id': 'https://openalex.org/keywords/targeted-therapy', 'display_name': 'Targeted Therapy', 'score': 0.41354376}], 'concepts': [{'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.7519334}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.49557316}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4911966}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.4739045}, {'id': 'https://openalex.org/C15152581', 'wikidata': 'https://www.wikidata.org/wiki/Q7833966', 'display_name': 'Transduction (biophysics)', 'level': 2, 'score': 0.4713399}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42365664}, {'id': 'https://openalex.org/C2781230642', 'wikidata': 'https://www.wikidata.org/wiki/Q492646', 'display_name': 'Targeted therapy', 'level': 3, 'score': 0.41354376}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.350429}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.27130526}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.09394503}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.802', 'pdf_url': 'https://www.oncotarget.com/article/802/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3681490', 'pdf_url': 'https://europepmc.org/articles/pmc3681490?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681490', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10342/5672', 'pdf_url': 'https://thescholarship.ecu.edu/bitstream/10342/5672/1/oncotarget-03-1505.PMC3681490.pdf', 'source': {'id': 'https://openalex.org/S4306402312', 'display_name': "The Scholarship East Carolina University's Institutional Repository (East Carolina University)", 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I186335123', 'host_organization_name': 'East Carolina University', 'host_organization_lineage': ['https://openalex.org/I186335123'], 'host_organization_lineage_names': ['East Carolina University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://ruj.uj.edu.pl/xmlui/handle/item/165293', 'pdf_url': 'https://ruj.uj.edu.pl/xmlui/bitstream/handle/item/165293/dulinska-litewka_et-al_advances_in_targeting_signal_transduction_pathways_2012.pdf?sequence=1&isAllowed=y', 'source': {'id': 'https://openalex.org/S4306400316', 'display_name': 'Homo Politicus (Academy of Humanities and Economics in Lodz)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23455493', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.802', 'pdf_url': 'https://www.oncotarget.com/article/802/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 191, 'referenced_works': ['https://openalex.org/W117064954', 'https://openalex.org/W1495123612', 'https://openalex.org/W1497390456', 'https://openalex.org/W1500686771', 'https://openalex.org/W1501651718', 'https://openalex.org/W1505177863', 'https://openalex.org/W1512337118', 'https://openalex.org/W1514408827', 'https://openalex.org/W1515444995', 'https://openalex.org/W1515890326', 'https://openalex.org/W1517713315', 'https://openalex.org/W152746771', 'https://openalex.org/W1529336528', 'https://openalex.org/W1545338568', 'https://openalex.org/W1555659588', 'https://openalex.org/W1555772346', 'https://openalex.org/W1561405118', 'https://openalex.org/W1569244981', 'https://openalex.org/W1572483109', 'https://openalex.org/W1576167641', 'https://openalex.org/W1590222856', 'https://openalex.org/W1596038553', 'https://openalex.org/W1612669009', 'https://openalex.org/W1747881616', 'https://openalex.org/W1752845679', 'https://openalex.org/W1754519356', 'https://openalex.org/W1775236918', 'https://openalex.org/W1783132379', 'https://openalex.org/W182528749', 'https://openalex.org/W1852175132', 'https://openalex.org/W1855015466', 'https://openalex.org/W18603037', 'https://openalex.org/W1864827749', 'https://openalex.org/W186667078', 'https://openalex.org/W1886384046', 'https://openalex.org/W1895627253', 'https://openalex.org/W1901739712', 'https://openalex.org/W1910349555', 'https://openalex.org/W1910682241', 'https://openalex.org/W1918395140', 'https://openalex.org/W1934530049', 'https://openalex.org/W1939794051', 'https://openalex.org/W1950663654', 'https://openalex.org/W1955741537', 'https://openalex.org/W1964537889', 'https://openalex.org/W1964983320', 'https://openalex.org/W1970756592', 'https://openalex.org/W1976340735', 'https://openalex.org/W1979729004', 'https://openalex.org/W1980196398', 'https://openalex.org/W1983215963', 'https://openalex.org/W1984143603', 'https://openalex.org/W1984596145', 'https://openalex.org/W1986740965', 'https://openalex.org/W1987470990', 'https://openalex.org/W1987535942', 'https://openalex.org/W1987609297', 'https://openalex.org/W1987822201', 'https://openalex.org/W1988508668', 'https://openalex.org/W1989777825', 'https://openalex.org/W1989892577', 'https://openalex.org/W1991222141', 'https://openalex.org/W1991867384', 'https://openalex.org/W1993991670', 'https://openalex.org/W1995124818', 'https://openalex.org/W1995125154', 'https://openalex.org/W1996671937', 'https://openalex.org/W2006613419', 'https://openalex.org/W2009330908', 'https://openalex.org/W2009357683', 'https://openalex.org/W2011350626', 'https://openalex.org/W2012288557', 'https://openalex.org/W2015383616', 'https://openalex.org/W2017044230', 'https://openalex.org/W2017790777', 'https://openalex.org/W2017879596', 'https://openalex.org/W2018726770', 'https://openalex.org/W2019727983', 'https://openalex.org/W2024186186', 'https://openalex.org/W2025031829', 'https://openalex.org/W2026220209', 'https://openalex.org/W2026917502', 'https://openalex.org/W2027225829', 'https://openalex.org/W2027959569', 'https://openalex.org/W2029411138', 'https://openalex.org/W2032128015', 'https://openalex.org/W2032788851', 'https://openalex.org/W2033942462', 'https://openalex.org/W204043054', 'https://openalex.org/W2041255253', 'https://openalex.org/W2041797768', 'https://openalex.org/W2043376395', 'https://openalex.org/W2043398720', 'https://openalex.org/W2046416127', 'https://openalex.org/W2047195892', 'https://openalex.org/W2048417564', 'https://openalex.org/W2048458549', 'https://openalex.org/W2049876223', 'https://openalex.org/W2052273633', 'https://openalex.org/W2052935216', 'https://openalex.org/W2059888019', 'https://openalex.org/W2060187655', 'https://openalex.org/W2062367464', 'https://openalex.org/W2064064775', 'https://openalex.org/W2065824965', 'https://openalex.org/W2068873812', 'https://openalex.org/W2069618209', 'https://openalex.org/W2070794726', 'https://openalex.org/W2070988789', 'https://openalex.org/W2072730864', 'https://openalex.org/W2073845479', 'https://openalex.org/W2078262569', 'https://openalex.org/W2080376170', 'https://openalex.org/W2080542433', 'https://openalex.org/W2081873352', 'https://openalex.org/W2083393831', 'https://openalex.org/W2084196688', 'https://openalex.org/W2086920509', 'https://openalex.org/W2086926542', 'https://openalex.org/W2090836265', 'https://openalex.org/W2095833815', 'https://openalex.org/W2096009033', 'https://openalex.org/W2098588105', 'https://openalex.org/W2099426541', 'https://openalex.org/W2100453514', 'https://openalex.org/W2102036384', 'https://openalex.org/W2102807979', 'https://openalex.org/W2103132902', 'https://openalex.org/W2103205080', 'https://openalex.org/W2104919578', 'https://openalex.org/W2105246953', 'https://openalex.org/W2108218086', 'https://openalex.org/W2111252159', 'https://openalex.org/W2112196790', 'https://openalex.org/W2113305156', 'https://openalex.org/W2114062089', 'https://openalex.org/W2115568781', 'https://openalex.org/W2116009473', 'https://openalex.org/W2117945272', 'https://openalex.org/W2118754985', 'https://openalex.org/W2118995216', 'https://openalex.org/W2119924449', 'https://openalex.org/W2120313976', 'https://openalex.org/W2120518749', 'https://openalex.org/W2121114839', 'https://openalex.org/W2121647526', 'https://openalex.org/W2122217676', 'https://openalex.org/W2122338853', 'https://openalex.org/W2123023764', 'https://openalex.org/W2124361099', 'https://openalex.org/W2125356859', 'https://openalex.org/W2125789330', 'https://openalex.org/W2126877349', 'https://openalex.org/W2126940797', 'https://openalex.org/W2128983325', 'https://openalex.org/W2131746764', 'https://openalex.org/W2131969758', 'https://openalex.org/W2132506474', 'https://openalex.org/W2133540186', 'https://openalex.org/W2136099758', 'https://openalex.org/W2138541689', 'https://openalex.org/W2141093003', 'https://openalex.org/W2141846416', 'https://openalex.org/W2142973070', 'https://openalex.org/W2144809933', 'https://openalex.org/W2147066718', 'https://openalex.org/W2154714488', 'https://openalex.org/W2155488506', 'https://openalex.org/W2157782360', 'https://openalex.org/W2159624931', 'https://openalex.org/W2159892503', 'https://openalex.org/W2159894941', 'https://openalex.org/W2161980885', 'https://openalex.org/W2164049779', 'https://openalex.org/W2166310425', 'https://openalex.org/W2166353609', 'https://openalex.org/W2166484457', 'https://openalex.org/W2166795098', 'https://openalex.org/W2166924362', 'https://openalex.org/W2168142258', 'https://openalex.org/W2169589624', 'https://openalex.org/W2169771822', 'https://openalex.org/W2170269981', 'https://openalex.org/W2185666290', 'https://openalex.org/W2288706067', 'https://openalex.org/W2470998459', 'https://openalex.org/W2591501252', 'https://openalex.org/W2599420949', 'https://openalex.org/W48383640', 'https://openalex.org/W48948211', 'https://openalex.org/W52728234'], 'related_works': ['https://openalex.org/W4246428841', 'https://openalex.org/W4210978881', 'https://openalex.org/W3106028651', 'https://openalex.org/W2966233672', 'https://openalex.org/W2890433954', 'https://openalex.org/W2369434682', 'https://openalex.org/W2332505650', 'https://openalex.org/W2053366384', 'https://openalex.org/W2030055732', 'https://openalex.org/W1981686597'], 'abstract_inverted_index': {'//': [0, 373], 'James': [1, 369], 'A.': [2, 31, 370], 'McCubrey': [3], '1': [4, 9, 14, 23, 28, 33, 148], ',': [5, 10, 15, 19, 24, 29, 34, 38, 42, 46, 51, 55, 59, 63, 67, 72, 76, 80, 84, 88, 92, 96, 100, 104, 108, 112, 116, 120, 125, 129, 133, 137, 141], 'Linda': [6], 'S.': [7], 'Steelman': [8], 'William': [11], 'H.': [12], 'Chappell': [13], 'Lin': [16], 'Sun': [17], '1,2': [18], 'Nicole': [20], 'M.': [21, 48], 'Davis': [22], 'Stephen': [25], 'L.': [26], 'Abrams': [27], 'Richard': [30], 'Franklin': [32], 'Lucio': [35], 'Cocco': [36], '3': [37, 181], 'Camilla': [39], 'Evangelisti': [40], '4': [41, 45, 193], 'Francesca': [43], 'Chiarini': [44], 'Alberto': [47], 'Martelli': [49], '3,4': [50], 'Massimo': [52], 'Libra': [53], '5': [54, 58, 62, 66, 71, 75, 79, 83, 203], 'Saverio': [56], 'Candido': [57], 'Giovanni': [60], 'Ligresti': [61], 'Grazia': [64], 'Malaponte': [65], 'Maria': [68], 'C.': [69], 'Mazzarino': [70], 'Paolo': [73], 'Fagone': [74], 'Marco': [77], 'Donia': [78], 'Ferdinando': [81], 'Nicoletti': [82], 'Jerry': [85], 'Polesel': [86], '6': [87, 91, 213], 'Renato': [89], 'Talamini': [90], 'Jörg': [93], 'Bäsecke': [94], '7': [95, 226], 'Sanja': [97], 'Mijatovic': [98], '8': [99, 103, 235], 'Danijela': [101], 'Maksimovic-Ivanic': [102], 'Michele': [105], 'Milella': [106], '9': [107, 250], 'Agostino': [109], 'Tafuri': [110], '10': [111, 258], 'Joanna': [113], 'Dulińska-Litewka': [114], '11': [115, 119, 271], 'Piotr': [117], 'Laidler': [118], 'Antonio': [121], 'B.': [122], "D'Assoro": [123], '12': [124, 282], 'Lyudmyla': [126], 'Drobot': [127], '13': [128, 297], 'Kazuo': [130], 'Umezawa': [131], '14': [132, 310], 'Giuseppe': [134], 'Montalto': [135], '15': [136, 326], 'Melchiorre': [138], 'Cervello': [139], '16': [140, 339], 'and': [142, 152, 167, 217, 267, 286, 332, 517, 523], 'Zoya': [143], 'N.': [144], 'Demidenko': [145], '17': [146, 354], '.': [147], 'Department': [149, 163, 204, 227, 236, 263, 283, 311, 328, 355], 'of': [150, 156, 164, 170, 195, 205, 209, 215, 228, 231, 237, 246, 261, 264, 273, 284, 292, 300, 304, 306, 312, 321, 329, 335, 356, 418, 421, 430, 454, 457, 469, 482, 493, 504, 513], 'Microbiology': [151], 'Immunology,': [153, 238], 'Brody': [154], 'School': [155, 320], 'Medicine': [157, 315, 331], 'at': [158], 'East': [159, 174], 'Carolina': [160, 175], 'University': [161, 208, 230, 245, 260, 277, 319, 334], '2': [162], 'Communication': [165], 'Sciences': [166, 305], 'Disorders,': [168], 'College': [169, 291], 'Allied': [171], 'Health': [172], 'Sciences,': [173, 207], 'University,': [176], 'Greenville,': [177], 'North': [178], 'Carolina,': [179], 'USA': [180, 367], 'Dipartimento': [182], 'di': [183, 189, 220, 345], 'Scienze': [184], 'Biomediche': [185], 'e': [186, 347], 'Neuromotorie,': [187], 'Università': [188], 'Bologna,': [190, 191, 201], 'Italy': [192, 202, 212, 257, 270, 338, 353], 'Institute': [194, 299], 'Molecular': [196, 287, 313], 'Genetics,': [197], 'National': [198, 253, 302], 'Research': [199, 242], 'Council-IOR,': [200], 'Bio-Medical': [206], 'Catania,': [210, 211], 'Unit': [214], 'Epidemiology': [216], 'Biostatistics,': [218], 'Centro': [219], 'Riferimento': [221], 'Oncologico,': [222], 'IRCCS,': [223], 'Aviano,': [224], 'Italy.': [225], 'Medicine,': [229, 293, 322], 'Göttingen,': [232, 233], 'Germany': [234], 'Instititue': [239], 'for': [240, 466], 'Biological': [241], '"Sinisa': [243], 'Stankovic",': [244], 'Belgrade,': [247, 248], 'Serbia': [249], 'Regina': [251], 'Elena': [252], 'Cancer': [254, 362, 380], 'Institute,': [255, 363], 'Rome,': [256, 262, 269], 'Sapienza,': [259], 'Cellular': [265], 'Biotechnology': [266], 'Hematology,': [268], 'Chair': [272], 'Medical': [274, 278, 318], 'Biochemistry,': [275, 301], 'Jagiellonian': [276], 'College,': [279], 'Kraków,': [280], 'Poland.': [281], 'Biochemistry': [285], 'Biology,': [288, 359], 'Mayo': [289], 'Clinic': [290], 'Rochester,': [294], 'MN,': [295], 'USA.': [296], 'Palladin': [298], 'Academy': [303], 'Ukraine,': [307], 'Kyiv,': [308], 'Ukraine': [309], 'Target': [314], 'Screening,': [316], 'Aichi': [317], 'Nagakute,': [323], 'Aichi,': [324], 'Japan': [325], 'Biomedical': [327], 'Internal': [330], 'Specialties,': [333], 'Palermo,': [336, 337, 352], 'Consiglio': [340], 'Nazionale': [341], 'delle': [342], 'Ricerche,': [343], 'Istituto': [344], 'Biomedicina': [346], 'Immunologia': [348], 'Molecolare': [349], '"Alberto': [350], 'Monroy",': [351], 'Cell': [357], 'Stress': [358], 'Roswell': [360], 'Park': [361], 'Buffalo,': [364], 'New': [365], 'York,': [366], 'Correspondence:': [368], 'McCubrey,': [371], 'email:': [372], 'Keywords': [374], ':': [375, 390, 395, 400], 'Targeted': [376], 'Therapy,': [377], 'Therapy': [378], 'Resistance,': [379], 'Stem': [381], 'Cells,': [382], 'Raf,': [383], 'Akt,': [384], 'PI3K,': [385], 'mTOR,': [386], 'AMPK,': [387], 'Metformin': [388], 'Received': [389], 'December': [391, 396, 401], '27,': [392], '2012,': [393, 398], 'Accepted': [394], '28,': [397], 'Published': [399], '30,': [402], '2012': [403], 'Abstract': [404], 'Over': [405], 'the': [406, 419, 428, 452, 467, 480, 494, 497, 502, 511, 518], 'past': [407, 498], 'few': [408, 499], 'years,': [409], 'significant': [410], 'advances': [411], 'have': [412], 'occurred': [413], 'in': [414, 437, 508], 'both': [415], 'our': [416], 'understanding': [417], 'complexity': [420], 'signal': [422, 514], 'transduction': [423, 515], 'pathways': [424, 507, 516], 'as': [425, 427], 'well': [426], 'isolation': [429], 'specific': [431], 'inhibitors': [432], 'which': [433, 477], 'target': [434], 'key': [435, 505], 'components': [436], 'those': [438], 'pathways.': [439], 'Furthermore': [440], 'critical': [441], 'information': [442], 'is': [443], 'being': [444, 475], 'accrued': [445], 'regarding': [446], 'how': [447], 'genetic': [448, 463, 519], 'mutations': [449], 'can': [450], 'affect': [451], 'sensitivity': [453, 522], 'various': [455, 509], 'types': [456], 'patients': [458], 'to': [459, 485, 525], 'targeted': [460, 472, 526], 'therapy.': [461], 'Finally,': [462], 'mechanisms': [464, 520], 'responsible': [465], 'development': [468], 'resistance': [470, 524], 'after': [471], 'therapy': [473], 'are': [474], 'discovered': [476], 'may': [478], 'allow': [479], 'creation': [481], 'alternative': [483], 'therapies': [484], 'overcome': [486], 'resistance.': [487], 'This': [488], 'review': [489], 'will': [490], 'discuss': [491], 'some': [492], 'highlights': [495], 'over': [496], 'years': [500], 'on': [501], 'roles': [503], 'signaling': [506], 'diseases,': [510], 'targeting': [512], 'governing': [521], 'therapies.': [527]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2101694285', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 9}], 'updated_date': '2024-12-16T11:21:50.051617', 'created_date': '2016-06-24'}