Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2101651255', 'doi': 'https://doi.org/10.1096/fj.13-233247', 'title': 'Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimullerian hormone expression during oocyte maturation in the female follicle', 'display_name': 'Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimullerian hormone expression during oocyte maturation in the female follicle', 'publication_year': 2013, 'publication_date': '2013-12-26', 'ids': {'openalex': 'https://openalex.org/W2101651255', 'doi': 'https://doi.org/10.1096/fj.13-233247', 'mag': '2101651255', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24371124'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fj.13-233247', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051953498', 'display_name': 'Renata Prunskaitė-Hyyryläinen', 'orcid': 'https://orcid.org/0000-0001-5453-2983'}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Renata Prunskaite‐Hyyrylainen', 'raw_affiliation_strings': ['Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland'], 'affiliations': [{'raw_affiliation_string': 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland', 'institution_ids': ['https://openalex.org/I98381234']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067649716', 'display_name': 'Jingdong Shan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Jingdong Shan', 'raw_affiliation_strings': ['Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland'], 'affiliations': [{'raw_affiliation_string': 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland', 'institution_ids': ['https://openalex.org/I98381234']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000710162', 'display_name': 'Antti Railo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Antti Railo', 'raw_affiliation_strings': ['Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland'], 'affiliations': [{'raw_affiliation_string': 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland', 'institution_ids': ['https://openalex.org/I98381234']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061053100', 'display_name': 'Krista M. Heinonen', 'orcid': 'https://orcid.org/0000-0002-2410-4432'}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}, {'id': 'https://openalex.org/I4210096154', 'display_name': 'Institute for Research in Immunology and Cancer', 'ror': 'https://ror.org/00wj6x496', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096154']}, {'id': 'https://openalex.org/I70931966', 'display_name': 'Université de Montréal', 'ror': 'https://ror.org/0161xgx34', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I70931966']}, {'id': 'https://openalex.org/I39481719', 'display_name': 'Institut National de la Recherche Scientifique', 'ror': 'https://ror.org/04td37d32', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I39481719', 'https://openalex.org/I49663120']}], 'countries': ['CA', 'FI'], 'is_corresponding': False, 'raw_author_name': 'Krista M. Heinonen', 'raw_affiliation_strings': ['Institut National de la Recherche Scientifique (INRS), Institut Armand-Frappier, Laval, Quebec, Canada', 'Institute for Research in Immunology and Cancer, Université de MontréalMontrealQuebecCanada', 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland'], 'affiliations': [{'raw_affiliation_string': 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland', 'institution_ids': ['https://openalex.org/I98381234']}, {'raw_affiliation_string': 'Institute for Research in Immunology and Cancer, Université de MontréalMontrealQuebecCanada', 'institution_ids': ['https://openalex.org/I4210096154', 'https://openalex.org/I70931966']}, {'raw_affiliation_string': 'Institut National de la Recherche Scientifique (INRS), Institut Armand-Frappier, Laval, Quebec, Canada', 'institution_ids': ['https://openalex.org/I39481719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085071497', 'display_name': 'Ilkka Miinalainen', 'orcid': 'https://orcid.org/0000-0002-3922-3442'}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Ilkka Miinalainen', 'raw_affiliation_strings': ['Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland'], 'affiliations': [{'raw_affiliation_string': 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland', 'institution_ids': ['https://openalex.org/I98381234']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002678361', 'display_name': 'Wenying Yan', 'orcid': 'https://orcid.org/0000-0001-5016-575X'}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}, {'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN', 'FI'], 'is_corresponding': False, 'raw_author_name': 'Wenying Yan', 'raw_affiliation_strings': ['Center for Systems Biology, Soochow University, Suzhou, Jiangsu, China', 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland'], 'affiliations': [{'raw_affiliation_string': 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland', 'institution_ids': ['https://openalex.org/I98381234']}, {'raw_affiliation_string': 'Center for Systems Biology, Soochow University, Suzhou, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081095213', 'display_name': 'Bairong Shen', 'orcid': 'https://orcid.org/0000-0003-2899-1531'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bairong Shen', 'raw_affiliation_strings': ['Center for Systems Biology, Soochow University, Suzhou, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Center for Systems Biology, Soochow University, Suzhou, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053448893', 'display_name': 'Claude Perreault', 'orcid': 'https://orcid.org/0000-0001-9453-7383'}, 'institutions': [{'id': 'https://openalex.org/I4210096154', 'display_name': 'Institute for Research in Immunology and Cancer', 'ror': 'https://ror.org/00wj6x496', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096154']}, {'id': 'https://openalex.org/I70931966', 'display_name': 'Université de Montréal', 'ror': 'https://ror.org/0161xgx34', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I70931966']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Claude Perreault', 'raw_affiliation_strings': ['Department of MedicineUniversité de MontréalMontrealQuebecCanada', 'Institute for Research in Immunology and Cancer, Université de MontréalMontrealQuebecCanada'], 'affiliations': [{'raw_affiliation_string': 'Institute for Research in Immunology and Cancer, Université de MontréalMontrealQuebecCanada', 'institution_ids': ['https://openalex.org/I4210096154', 'https://openalex.org/I70931966']}, {'raw_affiliation_string': 'Department of MedicineUniversité de MontréalMontrealQuebecCanada', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5044475923', 'display_name': 'Seppo Vainio', 'orcid': 'https://orcid.org/0000-0001-9319-3566'}, 'institutions': [{'id': 'https://openalex.org/I98381234', 'display_name': 'University of Oulu', 'ror': 'https://ror.org/03yj89h83', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I98381234']}], 'countries': ['FI'], 'is_corresponding': True, 'raw_author_name': 'Seppo J. Vainio', 'raw_affiliation_strings': ['Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland'], 'affiliations': [{'raw_affiliation_string': 'Oulu Centre for Cell Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine and Biocenter Oulu, Laboratory of Developmental Biology, University of Oulu, Oulu, Finland', 'institution_ids': ['https://openalex.org/I98381234']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5044475923'], 'corresponding_institution_ids': ['https://openalex.org/I98381234'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.505, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 54, 'citation_normalized_percentile': {'value': 0.943366, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '28', 'issue': '4', 'first_page': '1568', 'last_page': '1581'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11077', 'display_name': 'Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/polarity', 'display_name': 'Polarity (international relations)', 'score': 0.50416553}, {'id': 'https://openalex.org/keywords/antral-follicle', 'display_name': 'Antral follicle', 'score': 0.48772106}, {'id': 'https://openalex.org/keywords/anti-müllerian-hormone', 'display_name': 'Anti-Müllerian hormone', 'score': 0.43161437}, {'id': 'https://openalex.org/keywords/wnt4', 'display_name': 'WNT4', 'score': 0.42959505}], 'concepts': [{'id': 'https://openalex.org/C2776690073', 'wikidata': 'https://www.wikidata.org/wiki/Q3246226', 'display_name': 'Oocyte', 'level': 3, 'score': 0.7036932}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.66495854}, {'id': 'https://openalex.org/C2777361361', 'wikidata': 'https://www.wikidata.org/wiki/Q1112585', 'display_name': 'Polarity (international relations)', 'level': 3, 'score': 0.50416553}, {'id': 'https://openalex.org/C142773365', 'wikidata': 'https://www.wikidata.org/wiki/Q3499793', 'display_name': 'Antral follicle', 'level': 3, 'score': 0.48772106}, {'id': 'https://openalex.org/C2780536345', 'wikidata': 'https://www.wikidata.org/wiki/Q953556', 'display_name': 'Ovarian follicle', 'level': 3, 'score': 0.47407714}, {'id': 'https://openalex.org/C102570824', 'wikidata': 'https://www.wikidata.org/wiki/Q147807', 'display_name': 'Follicle', 'level': 2, 'score': 0.45243645}, {'id': 'https://openalex.org/C2778780466', 'wikidata': 'https://www.wikidata.org/wiki/Q21108939', 'display_name': 'Anti-Müllerian hormone', 'level': 3, 'score': 0.43161437}, {'id': 'https://openalex.org/C2781430442', 'wikidata': 'https://www.wikidata.org/wiki/Q15321841', 'display_name': 'WNT4', 'level': 4, 'score': 0.42959505}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42675105}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37289542}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.36670956}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34965008}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.34760806}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3340981}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.30676347}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.2757262}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.14679676}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.109656096}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.108433485}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07679358}], 'mesh': [{'descriptor_ui': 'D054304', 'descriptor_name': 'Anti-Mullerian Hormone', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006080', 'descriptor_name': 'Ovarian Follicle', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D060528', 'descriptor_name': 'Wnt4 Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054304', 'descriptor_name': 'Anti-Mullerian Hormone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054304', 'descriptor_name': 'Anti-Mullerian Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001485', 'descriptor_name': 'Basement Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017403', 'descriptor_name': 'In Situ Hybridization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046529', 'descriptor_name': 'Microscopy, Electron, Transmission', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006080', 'descriptor_name': 'Ovarian Follicle', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D006080', 'descriptor_name': 'Ovarian Follicle', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D006080', 'descriptor_name': 'Ovarian Follicle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060449', 'descriptor_name': 'Wnt Signaling Pathway', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060449', 'descriptor_name': 'Wnt Signaling Pathway', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060528', 'descriptor_name': 'Wnt4 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060528', 'descriptor_name': 'Wnt4 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fj.13-233247', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24371124', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320309938', 'funder_display_name': 'Centre of Excellence for Environmental Decisions, Australian Research Council', 'award_id': '2012–2017'}, {'funder': 'https://openalex.org/F4320311806', 'funder_display_name': 'Jalmari ja Rauha Ahokkaan Säätiö', 'award_id': None}, {'funder': 'https://openalex.org/F4320321108', 'funder_display_name': 'Academy of Finland', 'award_id': '251314'}, {'funder': 'https://openalex.org/F4320324148', 'funder_display_name': 'Orionin Tutkimussäätiö', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1498970130', 'https://openalex.org/W1512733937', 'https://openalex.org/W1965558704', 'https://openalex.org/W1966130563', 'https://openalex.org/W1967425557', 'https://openalex.org/W1971689970', 'https://openalex.org/W1974094726', 'https://openalex.org/W1976751554', 'https://openalex.org/W1976943401', 'https://openalex.org/W1989753106', 'https://openalex.org/W1990440494', 'https://openalex.org/W1993779367', 'https://openalex.org/W1995380492', 'https://openalex.org/W1997512109', 'https://openalex.org/W2001670860', 'https://openalex.org/W2003113589', 'https://openalex.org/W2011855715', 'https://openalex.org/W2015836595', 'https://openalex.org/W2019552711', 'https://openalex.org/W2021544762', 'https://openalex.org/W2022570365', 'https://openalex.org/W2023205001', 'https://openalex.org/W2029910368', 'https://openalex.org/W2041369790', 'https://openalex.org/W2047967799', 'https://openalex.org/W2048659659', 'https://openalex.org/W2053558395', 'https://openalex.org/W2055294634', 'https://openalex.org/W2078563810', 'https://openalex.org/W2098412813', 'https://openalex.org/W2100876394', 'https://openalex.org/W2104010513', 'https://openalex.org/W2105386866', 'https://openalex.org/W2106235028', 'https://openalex.org/W2107277218', 'https://openalex.org/W2110562063', 'https://openalex.org/W2116186946', 'https://openalex.org/W2119781755', 'https://openalex.org/W2120842955', 'https://openalex.org/W2121427165', 'https://openalex.org/W2122038030', 'https://openalex.org/W2126391360', 'https://openalex.org/W2133049275', 'https://openalex.org/W2140861044', 'https://openalex.org/W2143338249', 'https://openalex.org/W2148037570', 'https://openalex.org/W2148070806', 'https://openalex.org/W2153654530', 'https://openalex.org/W2154320004', 'https://openalex.org/W2165079421', 'https://openalex.org/W2169717724', 'https://openalex.org/W2171410951'], 'related_works': ['https://openalex.org/W4381248504', 'https://openalex.org/W4232890539', 'https://openalex.org/W2995643644', 'https://openalex.org/W2019552711', 'https://openalex.org/W2014475132', 'https://openalex.org/W2013714082', 'https://openalex.org/W2013048664', 'https://openalex.org/W2007535190', 'https://openalex.org/W2002527266', 'https://openalex.org/W1970235365'], 'abstract_inverted_index': {'Wnt4': [0, 20, 35, 50, 72, 151, 158, 170], 'is': [1, 172], 'a': [2, 48, 54, 214], 'key': [3], 'signal': [4, 216], 'that': [5, 133], 'channels': [6], 'the': [7, 11, 16, 34, 89, 92, 104, 120, 135, 148, 177, 192, 232], 'developmental': [8], 'fate': [9], 'of': [10, 119, 134, 141, 150, 176, 184, 191], 'indifferent': [12], 'mammalian': [13], 'gonad': [14], 'toward': [15], 'ovary,': [17], 'but': [18], 'whether': [19], 'has': [21], 'later': [22], 'roles': [23], 'during': [24, 174, 228], 'ovary': [25], 'development': [26], 'remains': [27], 'unknown.': [28], 'To': [29], 'investigate': [30], 'this,': [31, 157], 'we': [32], 'inactivated': [33], 'gene': [36, 162], 'by': [37, 128], 'crossing': [38], 'Amhr2Cre': [39], 'and': [40, 52, 65, 71, 95, 110, 117, 188, 224], 'doxycycline-inducible': [41], 'RosartTA-knock-in': [42], 'Cre': [43], 'mice': [44, 46], 'with': [45, 84, 132, 156], 'carrying': [47], 'floxed': [49], 'allele': [51], 'used': [53], 'novel': [55], 'Wnt4mCherry-knock-in': [56], 'mouse.': [57], 'In': [58], 'these': [59, 138], 'models,': [60], 'ovarian': [61, 78, 178], 'folliculogenesis': [62], 'was': [63, 68, 126, 145], 'compromised,': [64], 'female': [66, 233], 'fertility': [67], 'severely': [69], 'reduced,': [70], 'deficiency': [73], 'eventually': [74], 'led': [75], 'to': [76], 'premature': [77], 'failure.': [79], 'These': [80], 'anomalies': [81], 'were': [82], 'associated': [83], 'cell': [85, 105, 186, 219], 'polarity': [86], 'defects': [87], 'in': [88, 147, 153, 164, 167, 231], 'follicle.': [90, 234], 'Within': [91], 'follicle,': [93], 'laminin': [94], 'type': [96], 'IV': [97], 'collagen': [98], 'assembled': [99], 'ectopic': [100], 'basement': [101, 221], 'membrane–like': [102], 'structures,': [103], 'adherens': [106], 'junction': [107, 122], 'components': [108], 'N-cadherin': [109], 'β-catenin': [111], 'lost': [112], 'their': [113], 'polarized': [114, 189], 'expression': [115, 118, 140, 163, 183, 227], 'pattern,': [116], 'gap': [121], 'protein': [123], 'connexin': [124], '43': [125], 'reduced': [127], '~30%': [129], 'when': [130], 'compared': [131], 'controls.': [136], 'Besides': [137], 'changes,': [139], 'antimullerian': [142, 225], 'hormone': [143, 226], '(Amh)': [144], 'inhibited': [146], 'absence': [149], 'signaling': [152, 159, 171], 'vivo.': [154], 'Consistent': [155], 'up-regulated': [160], 'Amh': [161], 'KK1': [165], 'cells': [166], 'vitro.': [168], 'Thus,': [169], 'necessary': [173], 'maturation': [175, 230], 'follicles,': [179], 'where': [180], 'it': [181], 'coordinates': [182], 'Amh,': [185], 'survival,': [187], 'organization': [190], 'follicular': [193], 'cells.—Prunskaite-Hyyrylainen,': [194], 'R.,': [195], 'Shan,': [196], 'J.,': [197], 'Railo,': [198], 'A.,': [199], 'Heinonen,': [200], 'K.': [201], 'M.,': [202], 'Miinalainen,': [203], 'I.,': [204], 'Yan,': [205], 'W.,': [206], 'Shen,': [207], 'B.,': [208], 'Perreault,': [209], 'C.,': [210], 'Vainio,': [211], 'S.J.': [212], 'Wnt4,': [213], 'pleiotropic': [215], 'for': [217], 'controlling': [218], 'polarity,': [220], 'membrane': [222], 'integrity,': [223], 'oocyte': [229], 'FASEB': [235], 'J.': [236], '28,': [237], '28–1568': [238], '(1581).': [239], 'www.fasebj.org': [240]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2101651255', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2025-01-07T23:21:07.176708', 'created_date': '2016-06-24'}