The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics

Name: Work Video:
Duration: 3 min 30 s
Paola Panina‐Bordignon; Alberto Papi; Margherita Mariani; Pietro Di Lucia; Gian Luca Casoni; Cinzia Maria Bellettato; Cecilia Buonsanti; Deborah Miotto; Cristina E. Mapp; Antonello Villa; Gianluigi Arrigoni; Leonardo M. Fabbri; Francesco Sinigaglia
{'id': 'https://openalex.org/W2101436464', 'doi': 'https://doi.org/10.1172/jci12655', 'title': 'The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics', 'display_name': 'The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics', 'publication_year': 2001, 'publication_date': '2001-06-01', 'ids': {'openalex': 'https://openalex.org/W2101436464', 'doi': 'https://doi.org/10.1172/jci12655', 'mag': '2101436464', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11390417', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/209325'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci12655', 'pdf_url': 'http://www.jci.org/articles/view/12655/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/12655/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029201926', 'display_name': 'Paola Panina‐Bordignon', 'orcid': 'https://orcid.org/0000-0001-9913-8568'}, 'institutions': [{'id': 'https://openalex.org/I4210133214', 'display_name': 'IRCCS Ospedale San Raffaele', 'ror': 'https://ror.org/039zxt351', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133214', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paola Panina-Bordignon', 'raw_affiliation_strings': ['IRCCS Ospedale San Raffaele'], 'affiliations': [{'raw_affiliation_string': 'IRCCS Ospedale San Raffaele', 'institution_ids': ['https://openalex.org/I4210133214']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030660777', 'display_name': 'Alberto Papi', 'orcid': 'https://orcid.org/0000-0002-6924-4500'}, 'institutions': [{'id': 'https://openalex.org/I201324441', 'display_name': 'University of Ferrara', 'ror': 'https://ror.org/041zkgm14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I201324441']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alberto Papi', 'raw_affiliation_strings': ['University of ferrara'], 'affiliations': [{'raw_affiliation_string': 'University of ferrara', 'institution_ids': ['https://openalex.org/I201324441']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111518573', 'display_name': 'Margherita Mariani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Margherita Mariani', 'raw_affiliation_strings': ['F.Hoffmann-La Roche AG'], 'affiliations': [{'raw_affiliation_string': 'F.Hoffmann-La Roche AG', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067863979', 'display_name': 'Pietro Di Lucia', 'orcid': 'https://orcid.org/0000-0002-0726-1532'}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Pietro Di Lucia', 'raw_affiliation_strings': ['F.Hoffmann-La Roche AG'], 'affiliations': [{'raw_affiliation_string': 'F.Hoffmann-La Roche AG', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071123967', 'display_name': 'Gian Luca Casoni', 'orcid': 'https://orcid.org/0000-0002-7218-7914'}, 'institutions': [{'id': 'https://openalex.org/I201324441', 'display_name': 'University of Ferrara', 'ror': 'https://ror.org/041zkgm14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I201324441']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianluca Casoni', 'raw_affiliation_strings': ['University of ferrara'], 'affiliations': [{'raw_affiliation_string': 'University of ferrara', 'institution_ids': ['https://openalex.org/I201324441']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060075204', 'display_name': 'Cinzia Maria Bellettato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201324441', 'display_name': 'University of Ferrara', 'ror': 'https://ror.org/041zkgm14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I201324441']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cinzia Bellettato', 'raw_affiliation_strings': ['University of ferrara'], 'affiliations': [{'raw_affiliation_string': 'University of ferrara', 'institution_ids': ['https://openalex.org/I201324441']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025833826', 'display_name': 'Cecilia Buonsanti', 'orcid': 'https://orcid.org/0000-0001-5785-7695'}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Cecilia Buonsanti', 'raw_affiliation_strings': ['F.Hoffmann-La Roche AG'], 'affiliations': [{'raw_affiliation_string': 'F.Hoffmann-La Roche AG', 'institution_ids': ['https://openalex.org/I118019719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012421737', 'display_name': 'Deborah Miotto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201324441', 'display_name': 'University of Ferrara', 'ror': 'https://ror.org/041zkgm14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I201324441']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Deborah Miotto', 'raw_affiliation_strings': ['University of ferrara'], 'affiliations': [{'raw_affiliation_string': 'University of ferrara', 'institution_ids': ['https://openalex.org/I201324441']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108399330', 'display_name': 'Cristina E. Mapp', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201324441', 'display_name': 'University of Ferrara', 'ror': 'https://ror.org/041zkgm14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I201324441']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cristina Mapp', 'raw_affiliation_strings': ['University of ferrara'], 'affiliations': [{'raw_affiliation_string': 'University of ferrara', 'institution_ids': ['https://openalex.org/I201324441']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104110182', 'display_name': 'Antonello Villa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154387261', 'display_name': 'Vita-Salute San Raffaele University', 'ror': 'https://ror.org/01gmqr298', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I154387261']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Antonello Villa', 'raw_affiliation_strings': ['UNIVERSITÀ VITA-SALUTE, SAN RAFFAELE'], 'affiliations': [{'raw_affiliation_string': 'UNIVERSITÀ VITA-SALUTE, SAN RAFFAELE', 'institution_ids': ['https://openalex.org/I154387261']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023885483', 'display_name': 'Gianluigi Arrigoni', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210133214', 'display_name': 'IRCCS Ospedale San Raffaele', 'ror': 'https://ror.org/039zxt351', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133214', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianluigi Arrigoni', 'raw_affiliation_strings': ['IRCCS Ospedale San Raffaele'], 'affiliations': [{'raw_affiliation_string': 'IRCCS Ospedale San Raffaele', 'institution_ids': ['https://openalex.org/I4210133214']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010278392', 'display_name': 'Leonardo M. Fabbri', 'orcid': 'https://orcid.org/0000-0001-8894-1689'}, 'institutions': [{'id': 'https://openalex.org/I122346577', 'display_name': 'University of Modena and Reggio Emilia', 'ror': 'https://ror.org/02d4c4y02', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I122346577']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Leonardo M. Fabbri', 'raw_affiliation_strings': ['Univ of Modena and Reggio Emilia'], 'affiliations': [{'raw_affiliation_string': 'Univ of Modena and Reggio Emilia', 'institution_ids': ['https://openalex.org/I122346577']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040075886', 'display_name': 'Francesco Sinigaglia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118019719', 'display_name': 'Roche (Switzerland)', 'ror': 'https://ror.org/00by1q217', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I118019719']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Francesco Sinigaglia', 'raw_affiliation_strings': ['F.Hoffmann-La Roche AG'], 'affiliations': [{'raw_affiliation_string': 'F.Hoffmann-La Roche AG', 'institution_ids': ['https://openalex.org/I118019719']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 17.959, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 442, 'citation_normalized_percentile': {'value': 0.999909, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '107', 'issue': '11', 'first_page': '1357', 'last_page': '1364'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11532', 'display_name': 'Chemokine receptors and signaling', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ccr4', 'display_name': 'CCR4', 'score': 0.7908704}, {'id': 'https://openalex.org/keywords/ccl13', 'display_name': 'CCL13', 'score': 0.7206196}, {'id': 'https://openalex.org/keywords/ccr3', 'display_name': 'CCR3', 'score': 0.67324877}, {'id': 'https://openalex.org/keywords/ccl17', 'display_name': 'CCL17', 'score': 0.64964783}, {'id': 'https://openalex.org/keywords/cc-chemokine-receptors', 'display_name': 'CC chemokine receptors', 'score': 0.63566804}, {'id': 'https://openalex.org/keywords/cxcr3', 'display_name': 'CXCR3', 'score': 0.5589868}, {'id': 'https://openalex.org/keywords/ccl5', 'display_name': 'CCL5', 'score': 0.47229436}, {'id': 'https://openalex.org/keywords/xcl2', 'display_name': 'XCL2', 'score': 0.4233458}], 'concepts': [{'id': 'https://openalex.org/C2775866117', 'wikidata': 'https://www.wikidata.org/wiki/Q21102300', 'display_name': 'CCR4', 'level': 5, 'score': 0.7908704}, {'id': 'https://openalex.org/C29146819', 'wikidata': 'https://www.wikidata.org/wiki/Q21113975', 'display_name': 'CCL13', 'level': 5, 'score': 0.7206196}, {'id': 'https://openalex.org/C1423137', 'wikidata': 'https://www.wikidata.org/wiki/Q21113928', 'display_name': 'CCR3', 'level': 5, 'score': 0.67324877}, {'id': 'https://openalex.org/C143172330', 'wikidata': 'https://www.wikidata.org/wiki/Q1069599', 'display_name': 'CCL17', 'level': 5, 'score': 0.64964783}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.63739413}, {'id': 'https://openalex.org/C128879288', 'wikidata': 'https://www.wikidata.org/wiki/Q5009764', 'display_name': 'CC chemokine receptors', 'level': 5, 'score': 0.63566804}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.63058674}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.58664703}, {'id': 'https://openalex.org/C25532541', 'wikidata': 'https://www.wikidata.org/wiki/Q655541', 'display_name': 'CXCR3', 'level': 5, 'score': 0.5589868}, {'id': 'https://openalex.org/C116484652', 'wikidata': 'https://www.wikidata.org/wiki/Q3492926', 'display_name': 'CCL5', 'level': 5, 'score': 0.47229436}, {'id': 'https://openalex.org/C94205230', 'wikidata': 'https://www.wikidata.org/wiki/Q5005868', 'display_name': 'C-C chemokine receptor type 6', 'level': 5, 'score': 0.45726025}, {'id': 'https://openalex.org/C48001867', 'wikidata': 'https://www.wikidata.org/wiki/Q8041712', 'display_name': 'XCL2', 'level': 5, 'score': 0.4233458}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34671235}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.23004699}, {'id': 'https://openalex.org/C79484868', 'wikidata': 'https://www.wikidata.org/wiki/Q5971673', 'display_name': 'IL-2 receptor', 'level': 4, 'score': 0.19173658}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.17576179}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.0933224}], 'mesh': [{'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D019742', 'descriptor_name': 'Chemokines, CC', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019707', 'descriptor_name': 'Receptors, Chemokine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020545', 'descriptor_name': 'Respiratory Mucosa', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001706', 'descriptor_name': 'Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001985', 'descriptor_name': 'Bronchial Provocation Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019742', 'descriptor_name': 'Chemokines, CC', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008173', 'descriptor_name': 'Lung Diseases, Obstructive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008173', 'descriptor_name': 'Lung Diseases, Obstructive', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008173', 'descriptor_name': 'Lung Diseases, Obstructive', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054397', 'descriptor_name': 'Receptors, CCR3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054398', 'descriptor_name': 'Receptors, CCR4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054401', 'descriptor_name': 'Receptors, CCR8', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054367', 'descriptor_name': 'Receptors, CXCR3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019707', 'descriptor_name': 'Receptors, Chemokine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019707', 'descriptor_name': 'Receptors, Chemokine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020545', 'descriptor_name': 'Respiratory Mucosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020545', 'descriptor_name': 'Respiratory Mucosa', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D017565', 'descriptor_name': 'Sarcoidosis, Pulmonary', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017565', 'descriptor_name': 'Sarcoidosis, Pulmonary', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D017565', 'descriptor_name': 'Sarcoidosis, Pulmonary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci12655', 'pdf_url': 'http://www.jci.org/articles/view/12655/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc209325', 'pdf_url': 'https://europepmc.org/articles/pmc209325?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC209325', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11380/304306', 'pdf_url': 'https://iris.unimore.it/bitstream/11380/304306/1/JCI0112655.pdf', 'source': {'id': 'https://openalex.org/S4377196326', 'display_name': 'Iris Unimore (University of Modena and Reggio Emilia)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I122346577', 'host_organization_name': 'University of Modena and Reggio Emilia', 'host_organization_lineage': ['https://openalex.org/I122346577'], 'host_organization_lineage_names': ['University of Modena and Reggio Emilia'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11390417', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci12655', 'pdf_url': 'http://www.jci.org/articles/view/12655/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.8, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W121149184', 'https://openalex.org/W1485171755', 'https://openalex.org/W1496559392', 'https://openalex.org/W1528837080', 'https://openalex.org/W1537351363', 'https://openalex.org/W1565959221', 'https://openalex.org/W1609653960', 'https://openalex.org/W1648671938', 'https://openalex.org/W1729103553', 'https://openalex.org/W1833894873', 'https://openalex.org/W1892949664', 'https://openalex.org/W1939683868', 'https://openalex.org/W1976186260', 'https://openalex.org/W1981681632', 'https://openalex.org/W1987108574', 'https://openalex.org/W1991701804', 'https://openalex.org/W1994362051', 'https://openalex.org/W1996013522', 'https://openalex.org/W2011266350', 'https://openalex.org/W2015466937', 'https://openalex.org/W2020554497', 'https://openalex.org/W2028601606', 'https://openalex.org/W2042626190', 'https://openalex.org/W2047018108', 'https://openalex.org/W2048988599', 'https://openalex.org/W2063607822', 'https://openalex.org/W2067714902', 'https://openalex.org/W2075801677', 'https://openalex.org/W2081596482', 'https://openalex.org/W2081961844', 'https://openalex.org/W2082086413', 'https://openalex.org/W2089237353', 'https://openalex.org/W2102153142', 'https://openalex.org/W2102170885', 'https://openalex.org/W2113736505', 'https://openalex.org/W2117342688', 'https://openalex.org/W2118526748', 'https://openalex.org/W2130364297', 'https://openalex.org/W2130858592', 'https://openalex.org/W2149116434', 'https://openalex.org/W2154772518', 'https://openalex.org/W2160129587', 'https://openalex.org/W2161167143', 'https://openalex.org/W2163156754', 'https://openalex.org/W2168330263', 'https://openalex.org/W2170737790', 'https://openalex.org/W2315018741', 'https://openalex.org/W2336431486', 'https://openalex.org/W2462838772', 'https://openalex.org/W2465401158', 'https://openalex.org/W4210995779', 'https://openalex.org/W4285719527', 'https://openalex.org/W4292166591', 'https://openalex.org/W4313331406', 'https://openalex.org/W4313333788', 'https://openalex.org/W4313343491'], 'related_works': ['https://openalex.org/W2309837982', 'https://openalex.org/W2258844162', 'https://openalex.org/W2160129587', 'https://openalex.org/W2110714188', 'https://openalex.org/W2101436464', 'https://openalex.org/W2083239036', 'https://openalex.org/W2044983494', 'https://openalex.org/W1990895486', 'https://openalex.org/W1980316738', 'https://openalex.org/W190276270'], 'abstract_inverted_index': {'In': [0, 129], 'vitro': [1], 'polarized': [2], 'human': [3], 'Th2': [4], 'cells': [5, 67, 108, 134], 'preferentially': [6], 'express': [7, 68, 151], 'the': [8, 34, 42, 80, 96, 120, 126, 136, 165, 179], 'chemokine': [9, 22, 27, 39], 'receptors': [10, 40], 'CCR3,': [11], 'CCR4,': [12, 168], 'and': [13, 15, 25, 29, 38, 70, 100, 145, 150, 159, 173, 175, 186], 'CCR8': [14, 72, 160, 177], 'migrate': [16], 'to': [17, 131], 'their': [18], 'ligands:': [19], 'eotaxin,': [20], 'monocyte-derived': [21], '(MDC),': [23], 'thymus-': [24], 'activation-regulated': [26], '(TARC),': [28], 'I-309.': [30], 'We': [31], 'have': [32], 'studied': [33], 'expression': [35], 'of': [36, 45, 50, 79, 95, 115, 122, 138, 154, 167, 169, 176, 181], 'chemokines': [37], 'in': [41, 119, 178], 'airway': [43, 106], 'mucosa': [44], 'atopic': [46], 'asthmatics.': [47], 'Immunofluorescent': [48], 'analysis': [49], 'endobronchial': [51], 'biopsies': [52], 'from': [53], 'six': [54], 'asthmatics,': [55], 'taken': [56], '24': [57], 'hours': [58], 'after': [59], 'allergen': [60, 110], 'challenge,': [61, 111], 'demonstrates': [62], 'that': [63, 188], 'virtually': [64], 'all': [65], 'T': [66, 81, 92, 133], 'IL-4': [69], 'CCR4.': [71], 'is': [73, 85, 102], 'coexpressed': [74], 'with': [75, 140], 'CCR4': [76, 158], 'on': [77, 87, 91, 105], '28%': [78], 'cells,': [82], 'while': [83, 156], 'CCR3': [84], 'expressed': [86], 'eosinophils': [88], 'but': [89], 'not': [90], 'cells.': [93], 'Expression': [94], 'CCR4-specific': [97], 'ligands': [98, 171], 'MDC': [99, 172], 'TARC': [101], 'strongly': [103], 'upregulated': [104], 'epithelial': [107], 'upon': [109], 'suggesting': [112], 'an': [113], 'involvement': [114], 'this': [116], 'receptor/ligand': [117], 'axis': [118], 'regulation': [121], 'lymphocyte': [123], 'recruitment': [124], 'into': [125], 'asthmatic': [127, 184], 'bronchi.': [128], 'contrast': [130], 'asthma,': [132], 'infiltrating': [135], 'airways': [137], 'patients': [139], 'chronic': [141], 'obstructive': [142], 'pulmonary': [143, 146], 'disease': [144], 'sarcoidosis': [147], 'produce': [148], 'IFN-γ': [149], 'high': [152], 'levels': [153], 'CXCR3,': [155], 'lacking': [157], 'expression.': [161], 'These': [162], 'data': [163], 'support': [164], 'role': [166], 'its': [170], 'TARC,': [174], 'pathogenesis': [180], 'allergen-induced': [182], 'late': [183], 'responses': [185], 'suggest': [187], 'these': [189], 'molecules': [190], 'could': [191], 'be': [192], 'considered': [193], 'as': [194], 'targets': [195], 'for': [196], 'therapeutic': [197], 'intervention.': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2101436464', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 23}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-24T14:20:50.777914', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
