Publication Information

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2321, 2348, 2352, 2456, 2531, 2545, 2570, 2575, 2590, 2596, 2633, 2674, 2684, 2702, 2769, 2984, 3001, 3073, 3078, 3111, 3133, 3149, 3174, 3183, 3210, 3216, 3253, 3270, 3276, 3313, 3318, 3335, 3448, 3493, 3580, 3700, 3739, 3756, 3765, 3807, 3814, 3914, 3920, 4048, 4061, 4085, 4088, 4145, 4179, 4195, 4269, 4386, 4416, 4441, 4485], 'optineurin': [27, 46, 68, 101, 159, 221, 240, 262, 295, 353, 392, 840, 875, 925, 988, 1127, 1156, 1244, 1256, 1270, 1286, 1297, 1309, 1321, 1548, 1612, 1620, 1629, 1995, 2012, 3274, 3291, 3308, 3342, 3395, 3446, 3507, 3517, 3540, 3547, 3562, 3620, 3755, 3764, 3785, 3796, 3841, 3858, 3967, 4025, 4043, 4059, 4082, 4118, 4134, 4157, 4344, 4373, 4382, 4411, 4427, 4457, 4504, 4522], '(optic': [28, 222, 393], 'neuropathy': [29, 223, 394], 'inducing)': [30, 224], 'protein': [31, 225, 846, 961, 1997, 2059, 3095, 3332, 3404, 3621, 3637, 3670, 3682, 3994, 4223, 4250, 4284, 4326, 4437], 'were': [32, 226, 728, 1462, 1481, 1495, 1526, 1577, 1623, 1653, 1704, 1729, 1790, 1834, 1887, 1906, 1953, 2003, 2071, 2105, 2125, 2211, 2239, 2251, 2265, 2280, 2292, 2307, 2316, 2328, 2346, 2370, 2390, 2454, 2462, 2488, 2504, 2515, 2543, 2550, 2565, 2672, 2752, 2825, 2847, 2860, 2870, 2916, 3491, 3518, 3529, 3568, 3652, 3712, 3730, 4015, 4071, 4165, 4239, 4448], 'found': [33, 227, 729, 2024, 3912, 4144], 'associated': [34, 228, 400, 573, 3845], 'with': [35, 229, 401, 574, 734, 748, 919, 989, 1088, 1401, 1408, 1427, 1447, 1470, 1562, 1689, 1755, 1770, 1807, 1851, 1896, 1956, 1967, 2158, 2177, 2183, 2219, 2246, 2267, 2275, 2294, 2309, 2361, 2382, 2392, 2441, 2448, 2464, 2475, 2517, 2521, 2552, 2560, 2611, 2645, 2653, 2661, 2795, 2836, 2849, 2862, 2900, 3100, 3350, 3352, 3361, 3414, 3516, 3520, 3654, 3679, 3714, 3742, 3801, 3870, 3968, 4017, 4021, 4167, 4198, 4235, 4241, 4253, 4272, 4288, 4302, 4311, 4450, 4463, 4516], 'an': [36, 65, 90, 230, 259, 284, 575, 959, 1002, 1253, 2817, 3334, 3353, 3509, 3791, 4387], 'adult': [37, 231, 1999, 2103, 3141, 3255, 3271], 'form': [38, 118, 232, 312, 697, 808, 1084, 1319, 3083, 3340, 4143, 4186, 4229, 4238, 4321, 4455], 'glaucoma.': [40, 193, 234, 387, 739, 4149], 'To': [41, 235, 835, 1389, 1566, 3104, 3584, 3610, 3685, 3838, 3974, 4125], 'date,': [42, 236], 'role': [44, 238], 'neurodegeneration': [49, 243], 'process': [50, 244], 'that': [51, 61, 97, 147, 245, 255, 291, 341, 444, 876, 922, 1004, 1243, 1294, 1346, 3096, 3128, 3169, 3190, 3242, 3259, 3299, 3390, 3445, 3546, 3586, 3667, 3771, 3784, 3810, 3859, 3868, 3900, 3952, 4113, 4215, 4281, 4339, 4364, 4400, 4435, 4501, 4512], 'occurs': [52, 246], 'during': [53, 247, 3197, 3206], 'is': [55, 82, 249, 276, 438, 539, 567, 571, 642, 700, 743, 818, 841, 877, 1005, 1245, 1274, 2996, 3010, 3130, 3171, 3181, 3192, 3250, 3292, 3305, 3590, 3797, 3911, 3981, 4119, 4396], 'still': [56, 250], 'unknown.': [57, 251], 'We': [58, 252, 1282, 2014, 3015, 3323, 3388, 3410, 3499, 3665, 4055, 4150], 'now': [59, 253], 'report': [60, 254], 'response': [63, 257, 1251, 3503, 4442], 'apoptotic': [66, 260, 1254, 2877, 3510, 3554, 3792], 'stimulus,': [67, 261], 'changes': [69, 263, 507, 1257, 3813], 'subcellular': [70, 264, 1259, 3693, 4177], 'localization': [71, 265, 1260, 3385, 3400, 3694, 3934, 3959, 4178], 'translocates': [73, 267, 3548, 3671, 3786, 4292, 4327], 'from': [74, 104, 113, 268, 298, 307, 1261, 1314, 1361, 1397, 1485, 1646, 2010, 2897, 3021, 3032, 3067, 3086, 3122, 4422], 'Golgi': [76, 270, 1206, 1263, 3416, 3450, 3958, 4290], 'nucleus.': [79, 273, 1266], 'This': [80, 274, 2050, 2887, 3125, 3164, 3575, 3628, 4306], 'translocation': [81, 275, 1268, 3560, 3589, 3955, 4006, 4116, 4247, 4425], 'dependent': [83, 277, 1275, 3962, 4120], 'on': [84, 278, 634, 999, 1276, 1670, 1677, 2132, 2330, 2506, 2580, 2737, 2816, 2827, 2998, 3028, 3042, 3120, 3963, 3971, 4121, 4154], 'GTPase': [86, 280, 1037, 1278, 3805, 3873, 4123], 'activity': [87, 281, 1279, 3978], 'Rab8,': [89, 283, 1031, 3802, 4094], 'interactor': [91, 285], 'optineurin.': [93, 287, 3387, 4011, 4231], 'Furthermore,': [94, 288, 1305, 4359], 'we': [95, 289, 1241, 1292, 3065, 3084, 3114, 3187, 3535, 3544, 3599, 3613, 3622, 3676, 3690, 3749, 3762, 3852, 3898, 3983, 4136, 4174, 4213, 4263, 4279, 4468, 4480, 4509], 'demonstrate': [96, 290, 1242, 3783], 'overexpression': [99, 293, 1307, 3595, 4037, 4369, 4502], 'protects': [102, 296], 'H2O2-induced': [105, 299, 1302, 4423], 'cell': [106, 162, 173, 300, 356, 367, 1289, 1303, 3320, 3496, 3815, 4506], 'death': [107, 301], 'blocks': [109, 303, 1310], 'cytochrome': [110, 304, 1311], 'c': [111, 305, 1312, 2093, 2431], 'release': [112, 306, 1313], 'mitochondria.': [115, 309, 1316], 'A': [116, 310, 2706, 2925, 3039, 3201, 3930, 4207], 'mutated': [117, 311, 745, 1318, 1628, 4185, 4454], 'optineurin,': [120, 314, 1093, 4188, 4278, 4314], 'E50K,': [121, 315, 4172, 4189], 'identified': [122, 316, 1322], 'normal': [124, 318, 471, 749, 813, 1324, 2153, 2400], 'tension': [125, 319, 472, 814, 1325], 'patients': [127, 321, 1327, 4146], 'loses': [128, 322, 1328, 4347], 'its': [129, 323, 1258, 1329, 3850, 4176, 4348, 4356], 'ability': [130, 324, 1330, 4349], 'translocate': [132, 326, 1332, 4028], 'nucleus': [135, 329, 1273, 1335, 3551, 3674, 3789, 4009, 4031, 4046, 4103, 4295, 4330, 4430], 'when': [137, 331, 1337, 3302, 3391, 3566, 4097, 4203, 4300, 4315], 'overexpressed': [138, 332, 1338, 4092, 4204, 4377], 'compromises': [139, 333, 1339], 'mitochondrial': [141, 335, 1340], 'membrane': [142, 336, 1341, 1680, 3808], 'integrity': [143, 337, 1342], 'resulting': [144, 338, 1343], 'are': [148, 342, 399, 445, 623, 1298, 1347, 4412], 'less': [149, 343, 1348, 2040], 'fit': [150, 344, 1349], 'survive': [152, 346, 1351], 'under': [153, 347, 1352, 2374], 'stress': [154, 348, 1353, 4053], 'conditions.': [155, 349, 1354], 'The': [156, 350, 665, 694, 985, 1082, 1123, 1267, 1317, 1417, 1437, 1456, 1478, 1491, 1522, 1606, 1618, 1684, 1727, 1885, 1904, 1951, 2001, 2068, 2190, 2411, 2479, 2586, 2698, 2765, 2811, 3082, 3146, 3338, 3367, 3558, 3725, 3933, 4080, 4184], 'correlation': [157, 351], 'between': [158, 352], 'function': [160, 354, 838, 3329], 'survival': [163, 357, 3315], 'will': [164, 358], 'be': [165, 359, 1041, 1199, 2288, 3310, 3844, 3961, 4439], 'key': [166, 360], 'begin': [168, 362], 'understand': [170, 364, 4001], 'biology': [174, 368], 'signaling': [176, 370, 966], 'design': [179, 373], 'general': [180, 374], '"survival"': [181, 375], 'strategies': [182, 376], 'treat': [184, 378], 'a': [185, 189, 379, 383, 439, 807, 1032, 1095, 1402, 1433, 1678, 1690, 1707, 2006, 2021, 2039, 2128, 2646, 2828, 3002, 3029, 3093, 3116, 3225, 3235, 3262, 3295, 3319, 3415, 3707, 3751, 3803, 3854, 3906, 3985, 3990, 4052, 4168, 4191, 4265, 4482], 'disease': [186, 380, 4341], 'such': [188, 382, 926], 'complex': [190, 384, 2187], 'etiology': [191, 385], 'as': [192, 386, 812, 927, 1640, 1761, 2337, 2820, 2840, 3401, 3675, 3917, 3919, 3923, 4084, 4251, 4299, 4355, 4390, 4414], 'human': [391, 2029, 3006, 3080, 3102], 'inducing': [395], 'protein)': [396], 'gene,': [397, 3049], 'OPTN,': [398], 'adult-onset': [402], '(1Rezaie': [404, 751], 'T.': [405, 419, 752, 766, 787, 3453, 3467], 'Child': [406, 753, 3454], 'A.': [407, 754, 893, 3455], 'Hitchings': [408, 755, 3456], 'R.': [409, 421, 756, 768, 887, 3457, 3469, 3824], 'Brice': [410, 757, 3458], 'G.': [411, 758, 889, 1218, 3459], 'Miller': [412, 759, 3460], 'L.': [413, 609, 760, 3461], 'Coca-Prados': [414, 761, 3462], 'M.': [415, 427, 762, 774, 785, 1066, 3463, 3475], 'Heon': [416, 763, 3464], 'E.': [417, 764, 3426, 3465], 'Krupin': [418, 765, 3466], 'Ritch': [420, 767, 3468], 'Kreutzer': [422, 769, 3470], 'D.': [423, 664, 770, 3471], 'Crick': [424, 771, 3472], 'R.P.': [425, 772, 3473], 'Sarfarazi': [426, 773, 3474], 'Science.': [428, 775, 3476], '2002;': [429, 776, 3477], '295:': [430, 777, 3478], '1077-1079Crossref': [431, 778, 3479], 'PubMed': [432, 519, 533, 561, 597, 617, 719, 779, 800, 862, 905, 951, 980, 1023, 1060, 1077, 1118, 1149, 1182, 1233, 3438, 3480, 3833, 3892], 'Scopus': [433, 520, 534, 562, 598, 618, 720, 780, 801, 863, 906, 952, 981, 1024, 1061, 1078, 1119, 1150, 1183, 1234, 3439, 3481, 3834, 3893], '(922)': [434, 781, 3482], 'Google': [435, 522, 536, 564, 600, 620, 722, 782, 803, 865, 908, 954, 983, 1026, 1063, 1080, 1121, 1152, 1185, 1236, 3441, 3483, 3836, 3895], 'Scholar).': [436, 537, 565, 621, 678, 723, 866, 909, 984, 1027, 1081, 1122, 1153, 1186, 1237, 3837, 3896], 'Glaucoma': [437, 566], 'heterogeneous': [440, 569], 'group': [441], 'neuropathies': [443], 'characterized': [446, 849], 'by': [447, 637, 1421, 1441, 1497, 1511, 1528, 1615, 1625, 2060, 2141, 2195, 2439, 2659, 2872, 2918, 3638, 3732, 3735, 3925, 4074, 4374], 'progressive': [449], 'loss': [450], '(RGC),': [455], '4The': [456], 'abbreviations': [457], 'used': [458, 1760, 2281, 2489, 3614, 4218], 'are:': [459], 'RGC,': [460, 1248], 'cells;': [463], 'IOP,': [464, 688], 'intraocular': [465, 578], 'pressure;': [466], 'H2O2,': [467, 4022, 4242, 4466], 'hydrogen': [468], 'peroxide;': [469], 'NTG,': [470], 'glaucoma;': [473], 'TNF,': [474], 'tumor': [475], 'necrosis': [476], 'factor;': [477], 'GFP,': [478, 3351], 'green': [479], 'fluorescent': [480], 'protein;': [481], 'HA,': [482], 'hemagglutinin;': [483], 'CHAPS,': [484, 1881], '3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [485], 'acid;': [486], 'TRITC,': [487], 'tetramethylrhodamine': [488], 'isothiocyanate;': [489], 'PFA,': [490, 1839], 'paraformaldehyde;': [491], 'PBS,': [492, 1852, 2149, 2170, 2396, 2457, 2591, 2597, 2634], 'phosphate-buffered': [493, 1803], 'saline;': [494], 'E,': [495], 'embryonic': [496], 'stage.': [497], 'nerve,': [502], 'characteristic': [504], 'visual': [505], 'field': [506], '(2Quigley': [508], 'H.A.': [509, 525, 554], 'Green': [510, 2953], 'W.R.': [511], 'Ophthalmology.': [512], '1979;': [513], '86:': [514], '1803-1830Abstract': [515], 'Full': [516, 714, 716, 795, 797, 900, 902, 1055, 1057, 1113, 1115, 1177, 1179, 3433, 3435, 3887, 3889], 'Text': [517, 715, 717, 796, 798, 901, 903, 1056, 1058, 1114, 1116, 1178, 1180, 3434, 3436, 3888, 3890], 'PDF': [518, 718, 799, 904, 1059, 1117, 1181, 3437, 3891], '(279)': [521], 'Scholar,': [523, 601, 783, 1064], '3Quigley': [524], 'N.': [526], 'Engl.': [527], 'J.': [528, 556, 853, 894, 971, 1014, 1049, 1107, 1136, 1138, 1171, 1224, 1227, 1486, 3427, 3818, 3827, 3881, 3998], 'Med.': [529], '1993;': [530], '328:': [531], '1097-1106Crossref': [532], '(466)': [535], 'It': [538, 4395], 'one': [540, 825, 831, 2018], 'causes': [544], 'irreversible': [546], 'blindness': [547], 'affecting': [548], '∼67': [549], 'million': [550], 'people': [551], 'worldwide': [552], '(4Quigley': [553], 'Br.': [555], 'Ophthalmol.': [557, 788], '1996;': [558, 3830], '80:': [559], '389-393Crossref': [560], '(1977)': [563], 'genetically': [568], 'often': [572], 'increase': [576, 4484, 4518], 'pressure': [579], '(IOP)': [580], '(5Libby': [581], 'R.T.': [582], 'Gould': [583], 'D.B.': [584], 'Anderson': [585], 'M.G.': [586], 'John': [587], 'S.W.': [588], 'Annu.': [589], 'Rev.': [590, 1070], 'Genomics': [591], 'Hum.': [592, 1143], 'Genet.': [593, 1145], '2005;': [594, 614, 1230], '6:': [595], '15-44Crossref': [596], '(149)': [599], '6Morrison': [602], 'J.C.': [603], 'Johnson': [604], 'E.C.': [605], 'Cepurna': [606], 'W.': [607], 'Jia': [608], 'Prog.': [610], 'Retin.': [611], 'Eye': [612], 'Res.': [613, 947], '24:': [615], '217-240Crossref': [616], '(210)': [619], 'Glaucomas': [622], 'categorized': [624], 'into': [625, 1387, 1432, 1451, 1474, 1502, 1514, 1535, 1571, 1632, 3345, 3372, 4044, 4129], 'open': [626, 705, 737], 'angle,': [627, 629], 'closed': [628], 'congenital': [631], 'based': [633], 'mechanism': [636, 4003, 4132], 'which': [638, 2305], 'aqueous': [640], 'outflow': [641], 'impeded': [643], 'anterior': [646], 'chamber': [647], 'eye': [650, 1651, 3023, 3089, 3151, 3158, 3219], '(7Sheffield': [651], 'V.C.': [652], 'Alward': [653], 'W.L.': [654], 'Stone': [655], 'E.S.': [656], 'Scriver': [657], 'C.R.': [658], 'Beaudet': [659], 'A.L.': [660, 709], 'Sly': [661], 'W.S.': [662], 'Valle': [663], 'Metabolic': [666], 'Molecular': [668], 'Bases': [669], 'Inherited': [671], 'Disease.': [672], 'McGraw-Hill': [673], 'Inc.,': [674], 'New': [675], 'York2001:': [676], '6023-6076Google': [677], 'Risks': [679], 'for': [680, 1795, 1815, 1826, 1842, 1855, 1923, 2135, 2145, 2162, 2174, 2197, 2282, 2298, 2318, 2355, 2385, 2403, 2416, 2467, 2490, 2536, 2555, 2567, 2604, 2695, 2739, 2754, 2759, 2797, 2805, 2853, 2867, 2966, 3239, 3294, 3524, 3570, 3658, 4460], 'developing': [681, 3218], 'disease,': [683], 'addition': [685, 2744, 4433], 'elevated': [687], 'include': [689], 'myopia,': [690], 'race,': [691], 'age.': [693], 'most': [695], 'common': [696], 'autosomal': [702], 'dominant': [703, 1096, 3986], 'primary': [704, 736], 'angle': [706, 738], '(8Coleman': [708], 'Lancet.': [710], '1999;': [711], '354:': [712], '1803-1810Abstract': [713], '(224)': [721], 'Sequence': [724], 'alterations': [725], 'OPTN': [727, 2995], '16.7%': [731], 'families': [733, 747], 'hereditary': [735], 'Interestingly,': [740, 3224, 3897, 4479, 4508], 'this': [741, 1239, 3611, 3688, 3901], 'gene': [742, 3245], 'mainly': [744, 3172, 4192], 'IOP': [750, 3304], '9Sarfarazi': [784], 'Rezaie': [786], 'Clin.': [789], 'North': [790], 'Am.': [791], '2003;': [792], '16:': [793], '529-541Abstract': [794], '(62)': [802], 'Scholar)': [804, 955, 3442], 'thereby': [805], 'suffering': [806, 4147], 'known': [811, 1039, 3798], '(NTG).': [816], 'Optineurin': [817, 1028, 1187, 2980, 3283], '577': [819], 'amino': [820, 2248, 3358, 3864, 3876], 'acids': [821, 2031, 2044], 'long': [822], 'contains': [824], 'bZIP,': [826], 'two': [827, 2016], 'leucine': [828], 'zippers,': [829], 'zinc': [832], 'finger': [833], 'domain.': [834], 'date': [836], 'not': [842, 2066, 2884, 3076, 3144, 3233, 3487, 3591, 3643, 3941, 3947, 4078, 4225], 'known,': [843], 'although': [844], 'was': [847, 1359, 1395, 1419, 1439, 1509, 1549, 1613, 1668, 1687, 1753, 2139, 2193, 2414, 2437, 2497, 2588, 2614, 2643, 2700, 2767, 2813, 2889, 2906, 2928, 2978, 3343, 3563, 3577, 4244, 4309], 'partially': [848], '(10Li': [850, 968, 1011], 'Y.': [851, 969, 1012], 'Kang': [852, 970, 1013], 'Horwitz': [854, 972, 1015], 'M.S.': [855, 973, 1016], 'Mol.': [856, 974, 1017, 1071, 1144], 'Cell.': [857, 975, 1018], 'Biol.': [858, 895, 976, 1019, 1051, 1073, 1109, 1173, 1229, 3428, 3829, 3883], '1998;': [859, 977, 1020, 1146, 3430], '18:': [860, 978, 1021], '1601-1610Crossref': [861, 979, 1022], '(177)': [864, 982, 1025], 'Phorbol': [867], 'esters': [868], 'cytokines': [870], 'regulate': [871], 'expression': [873, 1621, 3107, 3148, 3180, 3204, 3215, 3237, 3265, 3275, 3347, 4404], 'phosphorylated': [878], 'following': [879, 1575, 2069, 2259, 2424, 2932], 'phorbol': [880], '12-myristate': [881], '13-acetate': [882], 'stimulation': [883, 3699, 3945, 4065, 4354, 4527], '(11Schwamborn': [884], 'K.': [885, 1047, 1105, 1169, 3826, 3879], 'Weil': [886], 'Courtois': [888], 'Whiteside': [890], 'S.T.': [891], 'Israel': [892], 'Chem.': [896, 3429], '2000;': [897, 948, 1052, 1110, 1174, 3884], '275:': [898], '22780-22789Abstract': [899], '(97)': [907], 'Its': [910], 'characterization': [911], 'also': [912, 1029, 1189, 1283, 2072, 3564, 4056, 4072, 4362, 4510], 'involved': [913, 962, 1042, 1200, 3312, 3806, 4440], 'identification': [915], 'several': [917, 3722], 'proteins': [918, 1010, 2365], 'diverse': [920], 'functions': [921], 'bind': [923], 'transcription': [928, 4520], 'factor': [929], 'IIIA': [930], '(12Moreland': [931], 'R.J.': [932], 'Dresser': [933], 'M.E.': [934, 1142], 'Rodgers': [935], 'J.S.': [936, 944], 'Roe': [937], 'B.A.': [938], 'Conaway': [939, 941], 'J.W.': [940], 'R.C.': [942, 1214], 'Hanas': [943], 'Nucleic': [945], 'Acids': [946], '28:': [949], '1986-1993Crossref': [950], '(49)': [953], 'E3-14.7': [957, 990, 997], 'K,': [958], 'adenovirus': [960], 'TNFα': [965], 'pathway': [967], 'interaction': [986], 'K': [991, 998, 1811], 'inhibits': [992], 'protective': [994], 'effect': [995, 1003], 'TNFα-induced': [1000], 'apoptosis,': [1001], 'independent': [1006], 'other': [1008], 'viral': [1009], 'binds': [1030, 1128], 'member': [1033], 'small': [1036, 3804, 3872], 'family': [1038], 'vesicular': [1044, 1166], 'transport': [1045], '(13Hattula': [1046, 1104, 1168, 3878], 'Peranen': [1048, 1106, 1170, 3880], 'Curr.': [1050, 1108, 1172, 3882], '10:': [1053, 1111, 1175, 3885], '1603-1606Abstract': [1054, 1112, 1176, 3886], '(188)': [1062, 1120, 1184, 3894], '14Zerial': [1065], 'McBride': [1067], 'H.': [1068, 3822], 'Nat.': [1069], 'Cell': [1072, 1228, 2204, 3828], '2001;': [1074], '2:': [1075], '107-117Crossref': [1076], '(2730)': [1079], 'activated': [1083], 'Rab8': [1086, 1099, 1479, 1500, 1524, 3847, 3874, 3969, 3972, 3980, 4122], 'interacts': [1087, 3869], 'amino-terminal': [1090, 3937], 'region': [1091, 1125, 1631, 2023, 2042, 3003, 3867], 'whereas': [1094], 'negative': [1097, 3987], 'GDP-bound': [1098], 'has': [1100, 1188, 3261], 'much': [1101], 'lower': [1102], 'affinity': [1103], 'carboxyl-terminal': [1124], 'Huntingtin': [1130, 1158, 1163], '(15Faber': [1131], 'P.W.': [1132], 'Barnes': [1133], 'G.T.': [1134], 'Srinidhi': [1135], 'Chen': [1137], 'Gusella': [1139], 'J.F.': [1140], 'MacDonald': [1141], '7:': [1147], '1463-1474Crossref': [1148], '(327)': [1151], 'When': [1154, 2313, 4012, 4232, 4262], 'co-expressed,': [1155], 'enhanced': [1159, 2663], 'recruitment': [1161], 'Rab8-positive': [1165], 'structures': [1167, 1652, 3159], 'been': [1190], 'shown': [1191, 4415], 'recently': [1192], 'link': [1194], 'myosin': [1195], 'VI': [1196], 'organization': [1203], 'apparatus': [1207], 'exocytosis': [1210], '(16Sahlender': [1211], 'D.A.': [1212], 'Roberts': [1213], 'Arden': [1215], 'S.D.': [1216], 'Spudich': [1217], 'Taylor': [1219], 'M.J.': [1220], 'Luzio': [1221], 'J.P.': [1222], 'Kendrick-Jones': [1223], 'Buss': [1225], 'F.': [1226], '169:': [1231], '285-295Crossref': [1232], '(331)': [1235], 'study': [1240, 3327, 3383], 'expressed': [1246, 3056, 3132, 3173, 3252], 'stimulus': [1255, 4106], 'Rab8.': [1281], 'investigated': [1284], 'whether': [1285, 3840, 3976], 'can': [1287], 'induce': [1288], 'survival,': [1290], 'observed': [1293, 2373, 3389, 3545, 3565, 3579, 3666, 3678, 3750, 3899, 4057, 4214, 4252, 4280, 4310, 4391, 4481, 4511], 'overexpressing': [1296, 3506, 4318], 'more': [1299, 3202], 'resistant': [1300], 'death.': [1304], 'Expression': [1355], 'Plasmids—Full-length': [1356], 'Optn': [1357, 1393, 1424, 1443, 1685, 1751, 3020, 3048, 3110, 3129, 3170, 3214, 3240, 3696, 4420], 'cDNA': [1358, 1394, 1425, 1444, 1460, 1686, 1752, 3063], 'amplified': [1360, 3066], 'mouse': [1362, 1996, 2048, 2992, 3019, 3075, 3088, 3142], 'mRNA': [1364], '(5′CCG': [1365], 'GAA': [1366, 1376, 1589, 2939], 'TTC': [1367, 1377, 1604], 'ATG': [1368], 'GTT': [1369, 1599], 'CAC': [1370, 1378], 'CCC': [1371], 'AGC': [1372], 'CTG3′': [1373], '5′CCG': [1375], 'ACA': [1379, 1380], 'AGA': [1381], 'TGC': [1382], 'CCA': [1383, 1590, 1591], 'CT3′)': [1384], 'cloned': [1386, 1467, 3016, 3085, 3344], 'pBS-SK.': [1388], 'generate': [1390, 1546], 'HA-Optn,': [1391], 'PCR-amplified': [1396], 'pBS': [1399], 'construct': [1400], 'proofreading': [1403], 'polymerase': [1404], 'placed': [1406], 'in-frame': [1407, 1426, 1446, 1469], 'HA': [1410, 1472, 3354], 'epitope': [1411, 1430, 1473], 'pcDNA3': [1414, 1454, 1476], 'plasmid': [1415, 1453, 1475], '(Invitrogen).': [1416, 1455, 1477, 2911, 2924], 'Myc-Optn': [1418], 'generated': [1420, 1440, 1527, 3853], 'placing': [1422, 1442], 'c-Myc': [1429, 3362], '5′': [1431, 1579], 'modified': [1434, 2215, 2533], 'pMT21': [1435], 'vector.': [1436], 'c-Myc/GFP-Optn': [1438], '3′': [1445, 1468], 'c-Myc/GFP': [1449], 'tag': [1450, 3058, 3355], 'artificially': [1457], 'deleted': [1458], 'Optn1': [1459], 'constructs': [1461, 1525], 'created': [1463], 'using': [1464, 1551, 1655, 2253, 2422, 2616, 2908, 2930, 3025, 3050, 3208, 3333, 3706], 'PCR': [1465, 1541, 2927], 'fragments': [1466], 'plasmids': [1480, 3371], 'kind': [1483], 'gift': [1484, 3996], 'Peranen,': [1487], 'University': [1488], 'Helinsky.': [1490], 'pEGFP-Rab8-22N': [1492], 'pEGFP-Rab8-67L': [1494], 'constructed': [1496, 1510, 1624], 'cloning': [1498, 1512, 1529, 1626], 'these': [1499, 3370, 4211, 4360], 'mutants': [1501], 'EcoRI-BamHI': [1504], 'sites': [1505, 1517, 1538], 'pEGFP-C1.': [1507], 'pEGFP-Rab8wt': [1508], 'Rab8wt': [1513], 'EcoRI-HindIII': [1516, 1537], 'pEGFP-C1A': [1519], '(modified': [1520], 'pEGFP-C1).': [1521], 'Myc-tagged': [1523, 1530], 'Rab8wt,': [1531], 'Rab8-22N,': [1532], 'Rab8-67L': [1534, 3993, 4039], 'pEGFP-N1.': [1540], 'Site-directed': [1542], 'Mutagenesis—Site-directed': [1543], 'mutagenesis': [1544, 1557, 4153], 'E50K': [1547, 1569, 1581, 2368, 4161, 4228, 4237, 4277, 4322, 4343, 4372, 4410], 'performed': [1550, 2252, 2415, 2615, 2890, 2929, 3115, 3536, 4151, 4264], 'commercially': [1553], 'available': [1554], 'QuickChange': [1555], 'site-directed': [1556, 4152], 'kit': [1558, 1695, 2665, 2923], '(Stratagene),': [1559], 'accordance': [1561], "manufacturer's": [1564, 1661, 1781, 2261, 2960], 'instructions.': [1565, 1662, 2262], 'introduce': [1567], 'mutation': [1570], 'wild-type': [1572, 3339, 3394, 4093, 4156, 4275, 4283, 4357, 4381, 4408, 4452, 4489], 'Optn,': [1573], 'oligonucleotides': [1576], 'used:': [1578, 2073], 'Opt': [1580], 'F,': [1582], '5′GAA': [1583], 'GGA': [1584], 'ACT': [1585], 'CCT': [1586], 'GGT': [1587], 'TAA': [1588], 'GCT': [1592], 'GAAA3′': [1593], '5′TTT': [1595], 'CAG': [1596, 1602], 'CTG': [1597], 'GTG': [1598], 'CTT': [1600], 'AAC': [1601], 'GAG': [1603, 2936], 'CTT3′.': [1605], 'DNA': [1607, 1693, 1723, 2279], 'sequence': [1608, 1616, 2975, 3030, 3045, 3057, 3064], 'mutant': [1611, 1619, 3939, 4142, 4320], 'confirmed': [1614, 3444, 4073], 'analysis.': [1617, 2492, 3163], 'vectors': [1622, 3348], 'coding': [1630], 'HA-pcDNA3,': [1634], 'pMT21,': [1635], 'c-Myc/GFP-pcDNA3,': [1636], 'FLAG-pcDNA3': [1638], '(Invitrogen)': [1639, 1658], 'described': [1641, 2338, 2496, 2821, 2841, 3077], 'above.': [1642, 2822, 2842], 'Northern': [1643, 3117, 3165], 'Blot—Total': [1644], 'RNA': [1645, 1667, 1702, 2896, 2915, 3024, 3090, 3121, 3209], 'various': [1647, 3123], 'organs': [1648], 'different': [1650, 2865, 2903, 3157, 3907], 'isolated': [1654], 'Trizol': [1656, 2909], 'reagent': [1657, 2257, 2910], 'according': [1659, 1778, 2957], '15': [1663, 2356, 2696, 2740, 2798, 3013], 'mg': [1664], 'total': [1666, 3022], 'separated': [1669, 2574, 3731], '1%': [1671, 1717], 'formaldehyde': [1672], 'agarose': [1673], 'gel': [1674, 2819], 'blotted': [1676], 'nylon': [1679], '(Roche': [1681, 1696, 1783, 1812, 1961, 1972, 2732], 'Applied': [1682, 1697, 1784, 1813, 1962, 1973, 2080, 2733, 2970], 'Science).': [1683, 1785], 'labeled': [1688], 'random': [1691], 'primer': [1692], 'labeling': [1694], 'Science)': [1698, 1814, 1974], '32P-labeled': [1700], 'dCTP.': [1701], 'blots': [1703, 3741], 'hybridized': [1705, 1888], 'mixture': [1708, 2007, 2731], '5×': [1710, 1714, 1868], 'SSC,': [1711, 1736, 1740, 1869, 1915], '50%': [1712, 1866, 2333, 2832], 'formamide,': [1713, 1867], "Denhardt's": [1715], 'solution,': [1716], 'SDS,': [1718, 1738], '100': [1719, 1981, 2223, 2227], 'μg/ml': [1720], 'salmon': [1721], 'sperm': [1722], 'at': [1724, 1731, 1798, 1818, 1845, 1858, 1890, 1920, 1937, 1948, 2111, 2165, 2230, 2406, 2419, 2470, 2499, 2527, 2607, 2691, 2762, 2800, 2808, 2902, 2962, 3220, 3228, 3356, 3363, 3603, 3721], '65': [1725, 1732], '°C.': [1726, 1950, 2609, 2764, 2810], 'filters': [1728], 'washed': [1730, 1801, 1848, 1907, 2168, 2308, 2455, 2516, 2673], '°C': [1733, 1892, 1922, 2232, 2965], '2×': [1735, 1914, 2951], '2%': [1737], '0.2×': [1739], '0.2%': [1741, 1840], 'SDS': [1742], 'before': [1743], 'exposure': [1744], 'x-ray': [1746], 'film.': [1747], 'Situ': [1749], 'Hybridization—Full-length': [1750], 'cut': [1754, 2126], 'XhoI': [1756], 'or': [1757, 1775, 1901, 2367, 2384, 2447, 2630, 2649, 2838, 2878, 3258, 3970, 4304, 4453], 'HindIII': [1758], 'template': [1762], 'synthesize': [1764], 'digoxigenin-labeled': [1765, 1771], 'anti-sense': [1766], 'sense': [1768, 1900], 'probes,': [1769], 'UTP': [1772], 'T7': [1774], 'Sp6': [1776], 'polymerase,': [1777], 'recommendations': [1782, 2961], 'E9.5': [1786], 'E10.5': [1788, 3221], 'embryos': [1789, 1886, 1952], 'fixed': [1791, 2106, 2351, 2544], '4%': [1793, 1838, 2108, 2353], 'PFA': [1794, 2109], '12': [1796], 'h': [1797, 1857, 2164, 2320, 2341, 2418, 2510, 2844, 2855, 3572, 4462], '4': [1799, 1819, 1846, 2112, 2763, 2801, 2809], '°C,': [1800, 1820, 1847, 2113, 2802], 'saline': [1804], '(PBS),': [1805], 'digested': [1806], '2.5': [1808, 2268], 'mg/ml': [1809, 1824, 1871, 1875, 2228], 'proteinase': [1810], '5': [1816, 1827, 1882, 2198, 2568, 2806], 'min': [1817, 1844, 1910, 1925, 1943, 2147, 2176, 2199, 2405, 2469, 2557, 2569, 2606, 2799, 2807, 3660, 4525], 'stopped': [1821], '2': [1823, 3000], 'glycine': [1825], 'min,': [1828], 'rinsed': [1830, 2347, 2589], 'PBS.': [1832], 'Samples': [1833], 'then': [1835, 2680, 2814, 3251, 3530, 4469], 'refixed': [1836], 'glutaraldehyde': [1841], '20': [1843, 3525, 3659, 4524], 'three': [1849, 3495], 'times': [1850], 'prehybridized': [1854], '3': [1856, 2163, 2417], '65°C': [1859], 'hybridization': [1861, 1894, 3212], 'solution': [1862, 1895, 2395], '(1%': [1863], 'Boehringer': [1864], 'Block,': [1865], '1': [1870, 2685, 2721, 2781, 2784, 2787, 2790, 2854, 4461], 'Torula': [1872], 'RNA,': [1873], '0.1': [1874, 2715, 2718], 'heparin,': [1876], '0.1%': [1877, 1880, 1918, 2150, 2171, 2397, 2458, 2592, 2602, 2639], 'Tween': [1878, 2593, 2603], '20,': [1879], 'mm': [1883, 1929, 1933, 1979, 1982, 1987, 2296, 2708, 2713, 2716, 2719, 2722, 2725, 2776, 2782, 2785, 2788, 2791, 2851, 3522, 3656, 3716, 4465], 'EDTA).': [1884], 'overnight': [1889, 1955, 2110], '70': [1891, 1921, 1949], '200': [1897], 'ng/ml': [1898], 'antisense': [1902], 'probe.': [1903], 'samples': [1905, 3719], 'twice,': [1908, 1941], '30': [1909, 1942, 2146, 2404, 2605, 2755, 2760], 'each': [1911, 1944, 2868, 3581], 'time,': [1912, 1945], 'pH': [1916, 1935, 1984, 2710], '7,': [1917], 'CHAPS': [1919], '10': [1924, 2468, 2556, 2675, 2712, 3008], 'MAB': [1927, 1947], '(100': [1928, 1978], 'maleic': [1930], 'acid,': [1931], '150': [1932], 'NaCl,': [1934, 1980, 2780], '7.5)': [1936], 'room': [1938, 2166, 2407, 2420, 2471], 'temperature,': [1939, 2167], 'incubated': [1954, 1966, 2157, 2173, 2293, 2391, 2520, 2794], 'anti-digoxigenin': [1957], 'alkaline': [1958], 'phosphatase-conjugated': [1959], 'antibody': [1960, 2051, 2076, 2095, 2412, 2624, 3629, 4217], 'Science),': [1963, 2081], 'washed,': [1964], 'nitro': [1968], 'blue': [1969], 'tetrazolium/5-bromo-4-chloro-3-indolyl': [1970], 'phosphate': [1971], 'staining': [1976, 4194], 'solutions': [1977], 'Tris-HCl,': [1983], '9.5,': [1985], '50': [1986, 2770], 'MgCl2).': [1988], 'Antibodies—We': [1989], 'produced': [1990, 3623], 'polyclonal': [1991, 2159, 2631, 3616, 4216], 'antibodies': [1992, 2002, 2070, 2445, 2451, 2485, 2613, 3617], 'against': [1993, 2005, 3618], 'rabbits.': [2000], 'made': [2004], 'peptides': [2009], 'protein.': [2013, 2049, 3103, 3609], 'chose': [2015], 'peptides,': [2017], 'corresponds': [2019, 2037, 3091], 'conserved': [2022, 2041], 'mouse,': [2026, 3113], 'rat,': [2027], '(amino': [2030, 2043], '91–110),': [2032], 'second': [2035], 'peptide': [2036], '278–297)': [2045], 'reveals': [2052, 3630], 'both': [2053, 3631, 4273], 'transfected': [2055, 2266, 2274, 2336, 2360, 2381, 2835, 2880, 3515, 3633, 3681, 4016, 4166, 4234, 4449, 4474], 'endogenous': [2058, 2387, 3403, 3608, 3636, 3669, 4024, 4042, 4081, 4222, 4313, 4325, 4380], 'immunoprecipitation': [2061], 'Western': [2063, 3640, 3740], 'blot': [2064, 3118, 3166, 3641], '(data': [2065, 3143, 3642, 3946, 4077], 'shown).': [2067, 3145, 3488, 3948, 4079], 'anti-HA': [2074, 2083, 2622], 'monoclonal': [2075, 2082, 2086, 2094, 2098, 2618, 2623], '(clone': [2077], '12CA5;': [2078], 'Roche': [2079], '(Babco),': [2084], 'anti-c-Myc': [2085, 2617], '9E10': [2087], 'antibody,': [2088], 'anti-FLAG': [2089], 'M2': [2090], '(Sigma),': [2091], 'anti-cytochrome': [2092], '(Promega),': [2096], 'anti-58K': [2099, 2434], '(Sigma).': [2100], 'Immunohistochemistry—Eyes': [2101], 'mice': [2104], 'cryoprotected': [2114], '30%': [2116], 'sucrose,': [2117], 'embedded': [2119], 'Tissue-Tek': [2121], '(Sakura).': [2122], '7-μm-thick': [2123], 'sections': [2124, 2144], 'cryostat': [2129], 'mounted': [2131, 2371, 2474, 2559], 'polylysine-coated': [2133], 'slides': [2134], 'immunohistochemistry.': [2136], 'Nonspecific': [2137], 'background': [2138], 'blocked': [2140, 2595], 'incubating': [2142], 'Tween,': [2151, 2172, 2398, 2459], '5%': [2152, 2399], 'goat': [2154, 2179, 2401], 'serum': [2155, 2402, 2600, 2637], 'subsequently': [2156], 'anti-optineurin': [2160, 2632, 3744], '1:200': [2161], '45': [2175, 2537], 'biotinylated': [2178], 'anti-rabbit,': [2180], 'reacted': [2182], 'avidin-biotinylated': [2185], 'peroxidase': [2186, 2655], '(Vector': [2188, 2202, 2477, 2562], 'Laboratories).': [2189, 2203, 2478, 2563], 'reaction': [2191], 'product': [2192], 'visualized': [2194], 'incubation': [2196, 2413, 2440, 2540], 'diaminobenzidine': [2201], 'Culture': [2205], 'Transfection—COS7': [2207], 'NIH3T3': [2209, 3512, 3650, 3710, 4013, 4163, 4270, 4316, 4446, 4513], 'grown': [2212, 2240, 2317, 2329, 2505, 2826], "Dulbecco's": [2214, 2532], "Eagle's": [2216, 2534], 'medium': [2217, 2244, 2322, 2535], 'supplemented': [2218, 2245], '10%': [2220], 'calf': [2221], 'serum,': [2222], 'units/ml': [2224], 'penicillin,': [2225], 'streptomycin': [2229], '37': [2231, 2608], 'a5%CO2': [2234], 'atmosphere.': [2235], 'Neuro': [2236, 3376], '2A': [2237, 3377], 'same': [2243, 3398, 4307], 'essential': [2247], 'acids.': [2249], 'Transfections': [2250], 'PolyFect': [2255], 'transfection': [2256, 2512, 3368, 4267, 4402], '(Qiagen)': [2258], '60-mm': [2263], 'dishes': [2264], 'μg': [2269, 2277], 'DNA.': [2271], '12-Well': [2272], 'plates': [2273], '0.75': [2276], 'immunofluorescence': [2283, 2494, 3537, 3646, 3780], 'assays.': [2284], 'order': [2286], 'stimulated,': [2289], '25': [2295, 2746, 2850, 3521, 3655, 3715, 4464], 'H2O2': [2297, 2852, 2901, 3523, 3657, 3698, 3717, 3774, 3944, 4105, 4303, 4353, 4393, 4432, 4517], 'defined': [2300], 'period': [2301], 'time': [2303, 2904, 3723], 'after': [2304, 2342, 2409, 2511, 3552, 3697, 4064, 4401, 4476, 4492, 4523], 'PBS': [2310, 2349, 2518, 2678, 2688], 'fixed.': [2312], 'serum-starved,': [2314], '24': [2319, 3571], 'containing': [2323], '0.5%': [2324], 'serum.': [2326], 'Immunofluorescence—Cells': [2327], 'coverslips': [2331], 'confluence': [2334, 2833], 'above;': [2339], '36': [2340, 2509, 2843], 'transfection,': [2343], 'paraformaldehyde': [2354], 'min.': [2357, 2538, 2697, 2741], 'Those': [2358], 'GFP': [2363], 'fusion': [2364], '(optineurin': [2366], 'optineurin)': [2369], 'fluorescence': [2376, 2873], 'microscope.': [2377], 'For': [2378], 'those': [2379], 'HA-optineurin': [2383], 'proteins,': [2388], 'blocking': [2394], 'temperature': [2408, 2421, 2472], 'fixation.': [2410], 'dilutions:': [2425], 'αHA': [2426], '1:400,': [2427], 'α-optineurin': [2428], '1:200,': [2429, 2432], 'α-cytochrome': [2430], '1:50.': [2435], 'Staining': [2436], 'completed': [2438], 'fluorescein': [2442], 'isothiocyanate-conjugated': [2443], 'anti-rabbit': [2444, 2480, 2650], '(Dako)': [2446], 'TRITC-conjugated': [2449], 'anti-mouse': [2450, 2483, 2648], '(Dako).': [2452], 'Cells': [2453, 2987], 'nuclei': [2461, 2549, 2859], 'counterstained': [2463, 2861], 'Hoechst': [2465, 2553], '(1:5000)': [2466, 2554], 'Vectastain': [2476, 2561], 'Cy3-conjugated': [2481], 'Cy2-conjugated': [2484], '(Jackson': [2486], 'ImmunoResearch)': [2487], 'confocal': [2491, 3926, 4075], 'Each': [2493], 'experiment': [2495, 2888, 3582, 4268], 'repeated': [2498], 'least': [2500], 'five': [2501, 2891], 'times.': [2502, 2892], 'MitoTracker—Cells': [2503], 'coverslips,': [2507], 'MitoTracker': [2522], 'MitoFluor': [2524], 'mitochondrion-selective': [2525], 'probes': [2526], '350': [2528], 'nm,': [2529], 'diluted': [2530], 'After': [2539, 2742], '3.7%': [2546], 'formaldehyde.': [2547], 'Finally,': [2548], 'counter-stained': [2551], 'Immunoblot—Proteins': [2564], 'boiled': [2566], 'reducing': [2571], 'sample': [2572], 'buffer,': [2573], '8%': [2576], 'SDS-PAGE,': [2577, 3736], 'electroblotted': [2579], 'nitrocellulose': [2581], 'membranes': [2582, 2587], '(Schleicher': [2583], '&': [2584], 'Schuell).': [2585], '3%': [2598, 2635], 'bovine': [2599, 2636], 'albumin,': [2601, 2638], 'Incubation': [2610], 'supernatant': [2619, 2812], '(1:5': [2620], 'dilution),': [2621], '(final': [2625], 'concentration': [2626, 3753], '0.8': [2627], 'μg/ml;': [2628], 'Babco),': [2629], 'Tween.': [2640], 'Antibody': [2641], 'binding': [2642], 'detected': [2644], 'secondary': [2647], 'IgG': [2651], 'coupled': [2652], 'horseradish': [2654], '(Amersham': [2656], 'Biosciences)': [2657], 'followed': [2658], 'visualization': [2660], 'chemiluminescence': [2664], '(Pierce).': [2666], 'Nuclear': [2667], 'Extracts—1': [2668], '×': [2669, 2693], '106': [2670], 'ml': [2676, 2686], 'scraped': [2681], 'collected': [2683], 'centrifuged': [2690, 2758, 2804], '13,000': [2692], 'g': [2694], 'pellet': [2699, 2766], 'resuspended': [2701, 2768], '400': [2703], 'μlofcold': [2704], 'buffer': [2705, 2773], '(10': [2707], 'Hepes,': [2709, 2777], '7.9,': [2711], 'KCl,': [2714], 'EDTA,': [2717, 2783], 'EGTA,': [2720, 2786], 'dithiothreitol,': [2723, 2789], '0.5': [2724], 'phenylmethylsulfonyl': [2726, 2792], 'fluoride,': [2727], '1×': [2728], 'protease': [2729], 'inhibitor': [2730], 'Science))': [2734], 'left': [2736], 'ice': [2738], 'μl': [2747, 2771], 'Nonidet': [2749], 'P-40,': [2750], 'vortexed': [2753], 's': [2756, 2761], 'C': [2774, 4259], '(20': [2775], '0.4': [2778], 'm': [2779], 'fluoride),': [2793], 'agitation': [2796], 'loaded': [2815], 'SDS-polyacrylamide': [2818], 'Apoptotic': [2823], 'Assay—Cells': [2824], '12-well': [2829], 'plate': [2830], 'GFP-optineurin': [2837], 'GFP-E50K': [2839], 'later': [2845, 3229], 'stimulated': [2848, 2885, 2899, 3653, 3713, 4020, 4240, 4301, 4459], 'fixed,': [2857, 3533], 'Hoechst.': [2863], 'Ten': [2864], 'fields': [2866], 'well': [2869, 3918], 'analyzed': [2871, 3738], 'microscopy': [2874, 3927, 4076], 'count': [2876], 'nonapoptotic': [2879], 'versus': [2882], 'control.': [2886], 'Real': [2893], 'Time': [2894], 'PCR—Total': [2895], 'points': [2905], 'extracted': [2907], 'Three': [2912], 'micrograms': [2913], 'retrotranscribed': [2917], 'SuperScript': [2919], 'II': [2920], 'first': [2921, 3862], 'strand': [2922], 'quantitative': [2926], 'primers:': [2933], '5′TTC': [2934], 'AAA': [2935, 2937], 'TCA': [2938], 'AAG': [2940], 'CCA3′': [2941], '5′CTC': [2943], 'CTC': [2944], 'CAA': [2945], 'GGC': [2946], 'TCT': [2947], 'GGG': [2948], 'A3′': [2949], 'SYBR': [2952], 'MasterMix': [2954], '(Applied': [2955], 'Biosystem)': [2956], 'Tm': [2963], '60': [2964], '40': [2967], 'cycles.': [2968], 'An': [2969, 3267], 'Biosystem': [2971], 'ABI': [2972], 'PRISM': [2973], '7000': [2974], 'detector': [2976], 'system': [2977], 'used.': [2979], 'Is': [2981], 'Mainly': [2982], 'Expressed': [2983], 'Ganglion': [2986], 'Mouse': [2990], 'Retina—The': [2991], 'homologue': [2993], 'located': [2997], 'chromosome': [2999, 3007], 'syntenic': [3004], 'composed': [3011], 'exons.': [3014], 'full-length': [3018], 'primers': [3026], 'designed': [3027], 'derived': [3031], 'transcript': [3033], 'predictions': [3034], 'genomic': [3037, 3044], 'sequence.': [3038], 'bioinformatic': [3040], 'analysis': [3041, 3119, 3126, 3167, 3205, 3227, 3269], 'Celera': [3051], '(Santa': [3052], 'Cruz': [3053], 'Biotechnology)': [3054], 'data': [3059, 3486, 3781, 3950, 4498], 'bases': [3060], 'plus': [3061], 'eye,': [3068, 3135], 'revealed': [3069, 3127, 3213, 3273, 3763], 'alternative': [3070], 'splice': [3071], 'variants': [3072], 'gene.': [3081], 'whole': [3087], '68-kDa': [3094], 'shares': [3097], '78%': [3098], 'identity': [3099], 'determine': [3105, 3585, 3975], 'profile': [3108], 'organs.': [3124], 'preferentially': [3131], 'heart,': [3136], 'muscle': [3138], 'strong': [3147], 'prompted': [3152], 'us': [3153, 3381], 'dissect': [3155], 'repeat': [3161], 'showed': [3168], '(Fig.': [3177, 3222, 3281, 3405, 3556, 3573, 3683, 3928, 4032, 4066, 4107, 4205, 4257, 4296, 4331, 4495, 4528], '1A).': [3178], 'Some': [3179], 'seen': [3182], 'choroid,': [3185], 'but': [3186, 4291], 'cannot': [3188], 'exclude': [3189], 'it': [3191, 3260], 'because': [3193, 3592], 'contamination': [3196], 'dissection': [3199], 'procedure.': [3200], 'detailed': [3203], 'development': [3207], 'situ': [3211], '1B).': [3223], 'similar': [3226], 'developmental': [3230], 'stages': [3231], 'did': [3232], 'detect': [3234], 'specific': [3236], 'pattern': [3238], 'suggesting': [3241, 3307], 'either': [3243], 'turns': [3246], 'off': [3247], 'completely': [3248], '(see': [3256, 3624, 3647], 'below)': [3257], 'low': [3263], 'ubiquitous': [3264], 'level.': [3266], 'immunohistochemistry': [3268], 'layer': [3280], '1D).': [3282], 'Translocates': [3284], 'Nucleus': [3287], 'Upon': [3288], 'Oxidative': [3289], 'Stress—Mutant': [3290], 'responsible': [3293], 'subtype': [3296], 'develops': [3300], 'even': [3301, 4047], 'normal,': [3306], 'might': [3309, 4438], 'directly': [3311], 'RGC': [3317], 'autonomous': [3321], 'manner.': [3322], 'therefore': [3324], 'decided': [3325, 3600], 'vitro': [3336], 'system.': [3337], 'mammalian': [3346], 'tagged': [3349, 4169], 'terminus': [3359], 'carboxyl': [3365], 'terminus.': [3366], 'NIH3T3,': [3373], 'COS7,': [3374], 'lines': [3379, 3497], 'allowed': [3380], 'overexpressed,': [3392], 'maintains': [3396], 'perinuclear': [3399, 4096], '2,': [3406], 'B': [3407], 'H).': [3409], 'double-labeled': [3411], 'marker': [3417], '(anti-58K)': [3418], '(17Gao': [3419], 'Y.S.': [3420], 'Alvarez': [3421], 'C.': [3422], 'Nelson': [3423], 'D.S.': [3424], 'Sztul': [3425], '273:': [3431], '33825-33834Abstract': [3432], '(68)': [3440], 'localizes': [3447, 3904], '(Ref.': [3451], '1Rezaie': [3452], 'Scholar': [3484], 'These': [3489, 3776, 3949, 4069, 4110, 4336, 4497], 'results': [3490, 3777, 4070, 4111, 4337, 4361], 'obtained': [3492], 'all': [3494], 'tested.': [3498], 'next': [3500], 'determined': [3501, 4175, 4470], 'upon': [3508, 3790, 3943, 4104, 4392, 4431], 'stimulus.': [3511, 3793, 4054], 'transiently': [3514], 'stressed': [3519], 'min;': [3526], 'harvested': [3531], 'observe': [3539], 'localization.': [3541], 'Most': [3542], 'unexpectedly,': [3543], 'stimuli': [3555, 4494], '2D).': [3557], 'nuclear': [3559, 3588, 3704, 3728, 3767, 3954, 4115, 4246], 'serum-starved': [3569], '2F).': [3574], 'result': [3576], 'consistently': [3578], 'performed.': [3583], 'protein,': [3598], 'look': [3602], 'behavior': [3605, 4139, 4308], 'end,': [3612], '"Material': [3625], 'Methods").': [3627], 'immunoprecipitation,': [3639], 'shown),': [3644], 'Fig.': [3648, 4417], '2).': [3649], 'subjected': [3662], 'immunofluorescence.': [3664], 'had': [3677], '2J).': [3684], 'further': [3686, 4127], 'confirm': [3687, 3778], 'result,': [3689], 'examined': [3691], 'cytosolic': [3702, 3726, 3758], 'fractions': [3705, 3729], 'biochemical': [3708], 'approach.': [3709], 'taken': [3720], 'points.': [3724], 'centrifugation,': [3733], 'resolved': [3734], 'antibody.': [3745], 'control': [3747, 4086, 4180], 'high': [3752], 'fraction.': [3759], 'As': [3760, 3794], 'expected,': [3761], 'fraction': [3768], 'received': [3772], 'treatment.': [3775], 'our': [3779], 'mentioned,': [3795], 'interact': [3800], 'trafficking': [3809], 'promotes': [3811], 'radical': [3812], 'shape': [3816], '(18Peranen': [3817], 'Auvinen': [3819], 'P.': [3820], 'Virta': [3821], 'Wepf': [3823], 'Simons': [3825], '135:': [3831], '153-167Crossref': [3832], '(217)': [3835], 'test': [3839], 'needs': [3842], 'change': [3849, 3942], 'localization,': [3851], 'truncated': [3855, 3902], 'version': [3856, 3903, 4170], 'lacks': [3860], '206': [3863], 'acids,': [3865], '(55–208': [3875], 'acids)': [3877], 'cellular': [3908], 'compartment': [3909], 'diffuse': [3913, 4060, 4193], 'cytoplasm': [3916, 4063], 'nucleus,': [3922, 4385], 'assayed': [3924], '3,': [3929, 4033, 4067, 4108], 'B).': [3932, 4209], 'deletion': [3938], 'does': [3940, 4224], 'suggested': [3951], 'could': [3960], 'association': [3965], 'activity.': [3973, 4124], 'necessary,': [3982], 'utilized': [3984], '(Rab8-22N)': [3988], 'constitutive': [3991], 'active': [3992], '(kind': [3995], 'Peraneen)': [3999], 'behind': [4004], 'Rab8-22N': [4018], 'failed': [4026], 'I–N).': [4034], 'Similarly,': [4035], 'forced': [4040], 'absence': [4050], 'some': [4058, 4199], 'O–T).': [4068], 'behaved': [4083], 'presence': [4090], 'remaining': [4095], 'nontreated': [4098], 'translocating': [4100, 4375], 'C–H).': [4109], 'indicate': [4112, 4338], 'gain': [4126], 'insight': [4128], 'biological': [4131], 'function,': [4135], 'studied': [4137], 'NTG': [4148], 'recreate': [4159], 'mutation.': [4162], 'H2O2-treated': [4182], 'cells.': [4183], 'shows': [4190], 'cytoplasm,': [4197], 'discrete': [4200], 'punctate': [4201], 'specks,': [4202], '4,': [4206, 4258, 4297, 4332], 'studies': [4212], 'reveal': [4220], 'recognize': [4226], 'there': [4243], 'no': [4245, 4285], 'wild': [4255], 'type': [4256], 'D).': [4261], 'double': [4266], 'longer': [4286], 'associates': [4287], 'E–G)': [4298], 'serum-starved.': [4305], 'H–J,': [4333], 'white': [4334], 'arrow).': [4335], 'causing': [4342], 'mislocalizes': [4345], 'respond': [4351, 4366], 'counterpart.': [4358], 'suggest': [4363, 4500], 'analogous': [4388], 'manner': [4389], 'stimulation.': [4394], 'important': [4397], 'note': [4399], 'levels': [4405], 'comparable,': [4413], '4K.': [4418], 'Wild-type': [4419], 'Protects': [4421], 'Apoptosis—The': [4424], 'suggests': [4434], 'oxidative': [4444], 'stress.': [4445], 'amount': [4472], 'stimuli.': [4478], 'significant': [4483], 'percentage': [4487], 'optineurin-expressing': [4490], '5A).': [4496], 'strongly': [4499], 'stimulates': [4505], 'survival.': [4507], 'treated': [4515], '5B),': [4529], 'clearly': [4530], 'indicatin': [4531]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2101375158', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2025-01-11T14:36:13.220298', 'created_date': '2016-06-24'}