Publication Information

{'id': 'https://openalex.org/W2101372918', 'doi': 'https://doi.org/10.1001/jama.295.17.2003', 'title': 'Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence', 'display_name': 'Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence', 'publication_year': 2006, 'publication_date': '2006-05-02', 'ids': {'openalex': 'https://openalex.org/W2101372918', 'doi': 'https://doi.org/10.1001/jama.295.17.2003', 'mag': '2101372918', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16670409'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1001/jama.295.17.2003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S172573765', 'display_name': 'JAMA', 'issn_l': '0098-7484', 'issn': ['0098-7484', '1538-3598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1001/jama.295.17.2003', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075420771', 'display_name': 'Raymond F. Anton', 'orcid': 'https://orcid.org/0000-0003-3417-6576'}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raymond F. Anton', 'raw_affiliation_strings': ['Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA.'], 'affiliations': [{'raw_affiliation_string': 'Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA.', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038076892', 'display_name': 'Stephanie S. O’Malley', 'orcid': 'https://orcid.org/0000-0002-1976-2369'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephanie S. O’Malley', 'raw_affiliation_strings': ['Yale University  ;'], 'affiliations': [{'raw_affiliation_string': 'Yale University  ;', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088673840', 'display_name': 'Domenic A. Ciraulo', 'orcid': 'https://orcid.org/0000-0001-7706-8765'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Domenic A. Ciraulo', 'raw_affiliation_strings': ['Boston University'], 'affiliations': [{'raw_affiliation_string': 'Boston University', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049134071', 'display_name': 'Ron A. Cisler', 'orcid': 'https://orcid.org/0000-0002-7781-5203'}, 'institutions': [{'id': 'https://openalex.org/I43579087', 'display_name': 'University of Wisconsin–Milwaukee', 'ror': 'https://ror.org/031q21x57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43579087']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ron A. Cisler', 'raw_affiliation_strings': ['Univ. of Wisconsin Milwaukee'], 'affiliations': [{'raw_affiliation_string': 'Univ. of Wisconsin Milwaukee', 'institution_ids': ['https://openalex.org/I43579087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089417042', 'display_name': 'David Couper', 'orcid': 'https://orcid.org/0000-0002-4313-9235'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Couper', 'raw_affiliation_strings': ['Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, NC, US'], 'affiliations': [{'raw_affiliation_string': 'Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, NC, US', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077256575', 'display_name': 'Dennis M. Donovan', 'orcid': 'https://orcid.org/0000-0003-2237-4292'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dennis M. Donovan', 'raw_affiliation_strings': [' University of Washington'], 'affiliations': [{'raw_affiliation_string': ' University of Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015054723', 'display_name': 'David R. Gastfriend', 'orcid': 'https://orcid.org/0000-0003-4871-3280'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David R. Gastfriend', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058654949', 'display_name': 'James D. Hosking', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'James D. Hosking', 'raw_affiliation_strings': ['University of Carolina'], 'affiliations': [{'raw_affiliation_string': 'University of Carolina', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032742542', 'display_name': 'Bankole A. Johnson', 'orcid': 'https://orcid.org/0000-0002-8901-6177'}, 'institutions': [{'id': 'https://openalex.org/I45438204', 'display_name': 'The University of Texas at San Antonio', 'ror': 'https://ror.org/01kd65564', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I45438204']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bankole A. Johnson', 'raw_affiliation_strings': ['University of Texas at San Antonio'], 'affiliations': [{'raw_affiliation_string': 'University of Texas at San Antonio', 'institution_ids': ['https://openalex.org/I45438204']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052596802', 'display_name': 'Joseph S. LoCastro', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Joseph S. LoCastro', 'raw_affiliation_strings': ['Boston University'], 'affiliations': [{'raw_affiliation_string': 'Boston University', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112768699', 'display_name': 'Richard Longabaugh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I175594653', 'display_name': 'John Brown University', 'ror': 'https://ror.org/02ct41q97', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I175594653']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Longabaugh', 'raw_affiliation_strings': ['Brown University'], 'affiliations': [{'raw_affiliation_string': 'Brown University', 'institution_ids': ['https://openalex.org/I175594653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113564868', 'display_name': 'Barbara J. Mason', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barbara J. Mason', 'raw_affiliation_strings': ['University of Miami,'], 'affiliations': [{'raw_affiliation_string': 'University of Miami,', 'institution_ids': ['https://openalex.org/I145608581']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113503524', 'display_name': 'Margaret E. Mattson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Margaret E. Mattson', 'raw_affiliation_strings': ['National Institutes of Health'], 'affiliations': [{'raw_affiliation_string': 'National Institutes of Health', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103507106', 'display_name': 'William R. Miller', 'orcid': None}, 'institutions': [], 'countries': ['MX', 'US'], 'is_corresponding': False, 'raw_author_name': 'William R. Miller', 'raw_affiliation_strings': ['University of New Mexico;'], 'affiliations': [{'raw_affiliation_string': 'University of New Mexico;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056190046', 'display_name': 'Helen M. Pettinati', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Helen M. Pettinati', 'raw_affiliation_strings': ['#N#               * University of Pennsylvania.'], 'affiliations': [{'raw_affiliation_string': '#N#               * University of Pennsylvania.', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012569208', 'display_name': 'Carrie L. Randall', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carrie L. Randall', 'raw_affiliation_strings': ['Medical University of South Carolina;'], 'affiliations': [{'raw_affiliation_string': 'Medical University of South Carolina;', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071772360', 'display_name': 'Robert M. Swift', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I175594653', 'display_name': 'John Brown University', 'ror': 'https://ror.org/02ct41q97', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I175594653']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Swift', 'raw_affiliation_strings': ['Brown University'], 'affiliations': [{'raw_affiliation_string': 'Brown University', 'institution_ids': ['https://openalex.org/I175594653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012668362', 'display_name': 'Roger D. Weiss', 'orcid': 'https://orcid.org/0000-0001-7503-828X'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roger D. Weiss', 'raw_affiliation_strings': ['Harvard University'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024412151', 'display_name': 'Lauren D. Williams', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lauren D. Williams', 'raw_affiliation_strings': ['University of Miami,'], 'affiliations': [{'raw_affiliation_string': 'University of Miami,', 'institution_ids': ['https://openalex.org/I145608581']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015770889', 'display_name': 'Allen Zweben', 'orcid': 'https://orcid.org/0000-0003-3832-0862'}, 'institutions': [{'id': 'https://openalex.org/I43579087', 'display_name': 'University of Wisconsin–Milwaukee', 'ror': 'https://ror.org/031q21x57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43579087']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Allen Zweben', 'raw_affiliation_strings': ['Univ. of Wisconsin Milwaukee'], 'affiliations': [{'raw_affiliation_string': 'Univ. of Wisconsin Milwaukee', 'institution_ids': ['https://openalex.org/I43579087']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111884521', 'display_name': 'for the COMBINE Study Research Group', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'for the COMBINE Study Research Group', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 11, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 73.262, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1860, 'citation_normalized_percentile': {'value': 0.999957, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '295', 'issue': '17', 'first_page': '2003', 'last_page': '2003'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10043', 'display_name': 'Substance Abuse Treatment and Outcomes', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10043', 'display_name': 'Substance Abuse Treatment and Outcomes', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10023', 'display_name': 'Schizophrenia research and treatment', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/acamprosate', 'display_name': 'Acamprosate', 'score': 0.68488324}, {'id': 'https://openalex.org/keywords/alcohol-dependence', 'display_name': 'Alcohol Dependence', 'score': 0.5716391}, {'id': 'https://openalex.org/keywords/pill', 'display_name': 'Pill', 'score': 0.5300034}, {'id': 'https://openalex.org/keywords/alcohol-use-disorder', 'display_name': 'Alcohol use disorder', 'score': 0.49343196}, {'id': 'https://openalex.org/keywords/relapse-prevention', 'display_name': 'Relapse prevention', 'score': 0.43430597}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.91962373}, {'id': 'https://openalex.org/C2777972943', 'wikidata': 'https://www.wikidata.org/wiki/Q409587', 'display_name': 'Naltrexone', 'level': 4, 'score': 0.8506695}, {'id': 'https://openalex.org/C2779992327', 'wikidata': 'https://www.wikidata.org/wiki/Q337668', 'display_name': 'Acamprosate', 'level': 5, 'score': 0.68488324}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.6071092}, {'id': 'https://openalex.org/C2779436514', 'wikidata': 'https://www.wikidata.org/wiki/Q4713263', 'display_name': 'Alcohol dependence', 'level': 3, 'score': 0.5716391}, {'id': 'https://openalex.org/C81603835', 'wikidata': 'https://www.wikidata.org/wiki/Q3457430', 'display_name': 'Pill', 'level': 2, 'score': 0.5300034}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.5276077}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.51987195}, {'id': 'https://openalex.org/C2779442783', 'wikidata': 'https://www.wikidata.org/wiki/Q15326', 'display_name': 'Alcohol use disorder', 'level': 3, 'score': 0.49343196}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4628806}, {'id': 'https://openalex.org/C27415008', 'wikidata': 'https://www.wikidata.org/wiki/Q7256382', 'display_name': 'Psychological intervention', 'level': 2, 'score': 0.445416}, {'id': 'https://openalex.org/C2780687700', 'wikidata': 'https://www.wikidata.org/wiki/Q210978', 'display_name': 'Abstinence', 'level': 2, 'score': 0.44118154}, {'id': 'https://openalex.org/C2781089641', 'wikidata': 'https://www.wikidata.org/wiki/Q7310684', 'display_name': 'Relapse prevention', 'level': 2, 'score': 0.43430597}, {'id': 'https://openalex.org/C207103383', 'wikidata': 'https://www.wikidata.org/wiki/Q3930246', 'display_name': 'Hazard ratio', 'level': 3, 'score': 0.4204223}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.40915257}, {'id': 'https://openalex.org/C2781066024', 'wikidata': 'https://www.wikidata.org/wiki/Q156', 'display_name': 'Alcohol', 'level': 2, 'score': 0.35270676}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.16439617}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.12348285}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.10341102}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.09258783}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000427', 'descriptor_name': 'Alcohol Deterrents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000437', 'descriptor_name': 'Alcoholism', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001521', 'descriptor_name': 'Behavior Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013654', 'descriptor_name': 'Taurine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000077443', 'descriptor_name': 'Acamprosate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000427', 'descriptor_name': 'Alcohol Deterrents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000437', 'descriptor_name': 'Alcoholism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015990', 'descriptor_name': 'Placebo Effect', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013654', 'descriptor_name': 'Taurine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013654', 'descriptor_name': 'Taurine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1001/jama.295.17.2003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S172573765', 'display_name': 'JAMA', 'issn_l': '0098-7484', 'issn': ['0098-7484', '1538-3598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16670409', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1001/jama.295.17.2003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S172573765', 'display_name': 'JAMA', 'issn_l': '0098-7484', 'issn': ['0098-7484', '1538-3598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.83, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 75, 'referenced_works': ['https://openalex.org/W109922458', 'https://openalex.org/W136754671', 'https://openalex.org/W1704316831', 'https://openalex.org/W1924226535', 'https://openalex.org/W1939011264', 'https://openalex.org/W1964393148', 'https://openalex.org/W1965171919', 'https://openalex.org/W1965591897', 'https://openalex.org/W1966288345', 'https://openalex.org/W1966882531', 'https://openalex.org/W1975381773', 'https://openalex.org/W1976670564', 'https://openalex.org/W1977914858', 'https://openalex.org/W1981722053', 'https://openalex.org/W1990621985', 'https://openalex.org/W1995605212', 'https://openalex.org/W2019102023', 'https://openalex.org/W2023831713', 'https://openalex.org/W2024785470', 'https://openalex.org/W2036704426', 'https://openalex.org/W2036800029', 'https://openalex.org/W2039993999', 'https://openalex.org/W2042217830', 'https://openalex.org/W2046071355', 'https://openalex.org/W2046979392', 'https://openalex.org/W2052199893', 'https://openalex.org/W2055727638', 'https://openalex.org/W2055734645', 'https://openalex.org/W2060821064', 'https://openalex.org/W2061707789', 'https://openalex.org/W2064255404', 'https://openalex.org/W2065920373', 'https://openalex.org/W2073941749', 'https://openalex.org/W2076078537', 'https://openalex.org/W2078307955', 'https://openalex.org/W2080999468', 'https://openalex.org/W2086730289', 'https://openalex.org/W2091793677', 'https://openalex.org/W2095483856', 'https://openalex.org/W2108258874', 'https://openalex.org/W2109714235', 'https://openalex.org/W2117060002', 'https://openalex.org/W2119705598', 'https://openalex.org/W2125405609', 'https://openalex.org/W2126519871', 'https://openalex.org/W2131293901', 'https://openalex.org/W2133661531', 'https://openalex.org/W2139188750', 'https://openalex.org/W2139226057', 'https://openalex.org/W2154717186', 'https://openalex.org/W2155575753', 'https://openalex.org/W2157113531', 'https://openalex.org/W2161478580', 'https://openalex.org/W2188846692', 'https://openalex.org/W2271771390', 'https://openalex.org/W2314062933', 'https://openalex.org/W2326556724', 'https://openalex.org/W2329158407', 'https://openalex.org/W2340424973', 'https://openalex.org/W2404183638', 'https://openalex.org/W2427493460', 'https://openalex.org/W2750648335', 'https://openalex.org/W2903333993', 'https://openalex.org/W3027262374', 'https://openalex.org/W3146540218', 'https://openalex.org/W4232334086', 'https://openalex.org/W4234774247', 'https://openalex.org/W4235354968', 'https://openalex.org/W4235890611', 'https://openalex.org/W4237161941', 'https://openalex.org/W4243294609', 'https://openalex.org/W4245564381', 'https://openalex.org/W4251022474', 'https://openalex.org/W4254875906', 'https://openalex.org/W4281687410'], 'related_works': ['https://openalex.org/W4241117421', 'https://openalex.org/W3048983859', 'https://openalex.org/W2586991307', 'https://openalex.org/W2157113531', 'https://openalex.org/W2152464253', 'https://openalex.org/W2124015705', 'https://openalex.org/W2103027398', 'https://openalex.org/W2074050247', 'https://openalex.org/W2073401427', 'https://openalex.org/W1972732013'], 'abstract_inverted_index': {'Alcohol': [0], 'dependence': [1, 46], 'treatment': [2, 43], 'may': [3, 17], 'include': [4], 'medications,': [5], 'behavioral': [6, 37, 116, 214], 'therapies,': [7, 38], 'or': [8, 103, 112, 175, 262, 269, 278, 301, 335, 350, 360], 'both.': [9, 270], 'It': [10], 'is': [11], 'unknown': [12], 'how': [13], 'combining': [14], 'these': [15, 320], 'treatments': [16], 'impact': [18], 'their': [19, 40], 'effectiveness,': [20], 'especially': [21], 'in': [22, 153, 199, 242, 363, 395], 'the': [23, 33, 197, 364], 'context': [24], 'of': [25, 35, 44, 80, 86, 91, 99, 224, 266, 347, 366, 384], 'primary': [26, 87], 'care': [27, 376, 397], 'and': [28, 39, 47, 77, 142, 170, 178, 193, 203, 306, 312, 371], 'other': [29], 'nonspecialty': [30], 'settings.To': [31], 'evaluate': [32, 49], 'efficacy': [34, 357], 'medication,': [36], 'combinations': [41], 'for': [42, 131], 'alcohol': [45, 88, 141], 'to': [48, 133, 144], 'placebo': [50, 293, 302], 'effect': [51, 254, 381], 'on': [52, 255, 339], 'overall': [53], 'outcome.Randomized': [54], 'controlled': [55], 'trial': [56], 'conducted': [57], 'January': [58], '2001-January': [59], '2004': [60], 'among': [61], '1383': [62], 'recently': [63], 'alcohol-abstinent': [64], 'volunteers': [65], '(median': [66], 'age,': [67], '44': [68], 'years)': [69], 'from': [70, 140], '11': [71], 'US': [72], 'academic': [73], 'sites': [74], 'with': [75, 96, 111, 263, 332, 349, 373, 389], 'Diagnostic': [76], 'Statistical': [78], 'Manual': [79], 'Mental': [81], 'Disorders,': [82], 'Fourth': [83], 'Edition,': [84], 'diagnoses': [85], 'dependence.Eight': [89], 'groups': [90, 149], 'patients': [92, 157, 402], 'received': [93, 122], 'medical': [94, 161, 168, 181, 204, 245, 279, 295, 304, 330, 367, 390], 'management': [95, 162, 169, 182, 205, 246, 280, 296, 305, 331, 391], '16': [97], 'weeks': [98], 'naltrexone': [100, 159, 177, 212, 359], '(100': [101], 'mg/d)': [102], 'acamprosate': [104, 343], '(3': [105], 'g/d),': [106], 'both,': [107], 'and/or': [108], 'both': [109, 176, 336], 'placebos,': [110], 'without': [113, 276, 351], 'a': [114, 210, 225, 374, 379], 'combined': [115], 'intervention': [117, 215], '(CBI).': [118], 'A': [119], 'ninth': [120], 'group': [121], 'CBI': [123, 166, 179, 275, 307, 361, 385], 'only': [124, 206], '(no': [125], 'pills).': [126], 'Patients': [127], 'were': [128, 323], 'also': [129, 221], 'evaluated': [130], 'up': [132], '1': [134], 'year': [135, 317], 'after': [136, 318], 'treatment.Percent': [137], 'days': [138, 189, 287], 'abstinent': [139, 190, 288], 'time': [143], 'first': [145], 'heavy': [146, 226], 'drinking': [147, 227, 256, 340], 'day.All': [148], 'showed': [150, 251, 344], 'substantial': [151], 'reduction': [152], 'drinking.': [154], 'During': [155, 271], 'treatment,': [156, 272, 319], 'receiving': [158, 201, 244, 274, 292, 329], 'plus': [160, 167, 180, 294, 303], '(n': [163, 172, 183, 207, 281, 298, 308], '=': [164, 173, 184, 208, 218, 236, 282, 299, 309], '302),': [165], 'placebos': [171, 202], '305),': [174, 209], '309)': [185], 'had': [186, 284, 378], 'higher': [187], 'percent': [188, 286], '(80.6,': [191], '79.2,': [192], '77.1,': [194], 'respectively)': [195], 'than': [196, 290, 358], '75.1': [198], 'those': [200, 243, 273, 291], 'significant': [211, 253], 'x': [213], 'interaction': [216], '(P': [217], '.009).': [219], 'Naltrexone': [220, 388], 'reduced': [222], 'risk': [223], 'day': [228], '(hazard': [229], 'ratio,': [230], '0.72;': [231], '97.5%': [232], 'CI,': [233], '0.53-0.98;': [234], 'P': [235], '.02)': [237], 'over': [238], 'time,': [239], 'most': [240], 'evident': [241], 'but': [247, 325], 'not': [248, 406], 'CBI.': [249, 352], 'Acamprosate': [250], 'no': [252, 326, 345], 'vs': [257], 'placebo,': [258], 'either': [259], 'by': [260], 'itself': [261], 'any': [264], 'combination': [265, 354], 'naltrexone,': [267, 333], 'CBI,': [268, 334], 'pills': [277, 370], '157)': [283], 'lower': [285], '(66.6)': [289], 'alone': [297, 362], '153)': [300], '156)': [310], '(73.8': [311], '79.8,': [313], 'respectively;': [314], 'P<.001).': [315], 'One': [316], 'between-group': [321], 'effects': [322], 'similar': [324], 'longer': [327], 'significant.Patients': [328], 'fared': [337], 'better': [338, 356], 'outcomes,': [341], 'whereas': [342], 'evidence': [346], 'efficacy,': [348], 'No': [353], 'produced': [355], 'presence': [365], 'management.': [368], 'Placebo': [369], 'meeting': [372], 'health': [375, 396], 'professional': [377], 'positive': [380], 'above': [382], 'that': [383], 'during': [386], 'treatment.': [387], 'could': [392], 'be': [393], 'delivered': [394], 'settings,': [398], 'thus': [399], 'serving': [400], 'alcohol-dependent': [401], 'who': [403], 'might': [404], 'otherwise': [405], 'receive': [407], 'treatment.clinicaltrials.gov': [408], 'Identifier:': [409], 'NCT00006206.': [410]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2101372918', 'counts_by_year': [{'year': 2024, 'cited_by_count': 67}, {'year': 2023, 'cited_by_count': 59}, {'year': 2022, 'cited_by_count': 65}, {'year': 2021, 'cited_by_count': 83}, {'year': 2020, 'cited_by_count': 237}, {'year': 2019, 'cited_by_count': 74}, {'year': 2018, 'cited_by_count': 85}, {'year': 2017, 'cited_by_count': 80}, {'year': 2016, 'cited_by_count': 86}, {'year': 2015, 'cited_by_count': 110}, {'year': 2014, 'cited_by_count': 94}, {'year': 2013, 'cited_by_count': 114}, {'year': 2012, 'cited_by_count': 123}], 'updated_date': '2025-01-06T16:17:53.100538', 'created_date': '2016-06-24'}