Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2100818755', 'doi': 'https://doi.org/10.1111/j.1476-5381.1977.tb07521.x', 'title': 'C‐FRAGMENT OF LIPOTROPIN—AN ENDOGENOUS POTENT ANALGESIC PEPTIDE', 'display_name': 'C‐FRAGMENT OF LIPOTROPIN—AN ENDOGENOUS POTENT ANALGESIC PEPTIDE', 'publication_year': 1977, 'publication_date': '1977-07-01', 'ids': {'openalex': 'https://openalex.org/W2100818755', 'doi': 'https://doi.org/10.1111/j.1476-5381.1977.tb07521.x', 'mag': '2100818755', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/560894', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1667279'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1476-5381.1977.tb07521.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1111/j.1476-5381.1977.tb07521.x', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004493892', 'display_name': 'W. Feldberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164902', 'display_name': 'National Institute for Medical Research', 'ror': 'https://ror.org/05fjs7w98', 'country_code': 'TZ', 'type': 'facility', 'lineage': ['https://openalex.org/I2801810276', 'https://openalex.org/I4210164902']}], 'countries': ['TZ'], 'is_corresponding': False, 'raw_author_name': 'W. FELDBERG', 'raw_affiliation_strings': ['National Institute for Medical Research, Mill Hill, London NW7 1AA'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Medical Research, Mill Hill, London NW7 1AA', 'institution_ids': ['https://openalex.org/I4210164902']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109862930', 'display_name': 'D.G. Smyth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164902', 'display_name': 'National Institute for Medical Research', 'ror': 'https://ror.org/05fjs7w98', 'country_code': 'TZ', 'type': 'facility', 'lineage': ['https://openalex.org/I2801810276', 'https://openalex.org/I4210164902']}], 'countries': ['TZ'], 'is_corresponding': False, 'raw_author_name': 'D.G. SMYTH', 'raw_affiliation_strings': ['National Institute for Medical Research, Mill Hill, London NW7 1AA'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Medical Research, Mill Hill, London NW7 1AA', 'institution_ids': ['https://openalex.org/I4210164902']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.452, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 111, 'citation_normalized_percentile': {'value': 0.85445, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '60', 'issue': '3', 'first_page': '445', 'last_page': '453'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mydriasis', 'display_name': 'Mydriasis', 'score': 0.6217818}, {'id': 'https://openalex.org/keywords/catalepsy', 'display_name': 'Catalepsy', 'score': 0.6016091}, {'id': 'https://openalex.org/keywords/nalorphine', 'display_name': 'Nalorphine', 'score': 0.47508946}], 'concepts': [{'id': 'https://openalex.org/C2777389121', 'wikidata': 'https://www.wikidata.org/wiki/Q81225', 'display_name': 'Morphine', 'level': 2, 'score': 0.8625681}, {'id': 'https://openalex.org/C2780820201', 'wikidata': 'https://www.wikidata.org/wiki/Q173235', 'display_name': 'Analgesic', 'level': 2, 'score': 0.643596}, {'id': 'https://openalex.org/C2779109636', 'wikidata': 'https://www.wikidata.org/wiki/Q1128283', 'display_name': 'Mydriasis', 'level': 2, 'score': 0.6217818}, {'id': 'https://openalex.org/C2780476085', 'wikidata': 'https://www.wikidata.org/wiki/Q918193', 'display_name': 'Catalepsy', 'level': 4, 'score': 0.6016091}, {'id': 'https://openalex.org/C2778750930', 'wikidata': 'https://www.wikidata.org/wiki/Q4540629', 'display_name': '(+)-Naloxone', 'level': 4, 'score': 0.53728276}, {'id': 'https://openalex.org/C2776657501', 'wikidata': 'https://www.wikidata.org/wiki/Q2622916', 'display_name': 'Nalorphine', 'level': 5, 'score': 0.47508946}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.46026522}, {'id': 'https://openalex.org/C57992300', 'wikidata': 'https://www.wikidata.org/wiki/Q2066956', 'display_name': 'Potency', 'level': 3, 'score': 0.43940833}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43353924}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.42792055}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4167009}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.30407336}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29297996}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.25577933}, {'id': 'https://openalex.org/C2780948584', 'wikidata': 'https://www.wikidata.org/wiki/Q251347', 'display_name': 'Haloperidol', 'level': 3, 'score': 0.21535686}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.07977268}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.07733476}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.06473011}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000700', 'descriptor_name': 'Analgesics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004723', 'descriptor_name': 'Endorphins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008083', 'descriptor_name': 'beta-Lipotropin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002375', 'descriptor_name': 'Catalepsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002375', 'descriptor_name': 'Catalepsy', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D002415', 'descriptor_name': 'Cats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004723', 'descriptor_name': 'Endorphins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004745', 'descriptor_name': 'Enkephalins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004745', 'descriptor_name': 'Enkephalins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008083', 'descriptor_name': 'beta-Lipotropin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008083', 'descriptor_name': 'beta-Lipotropin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1476-5381.1977.tb07521.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1667279', 'pdf_url': 'https://europepmc.org/articles/pmc1667279?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1667279', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/560894', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1476-5381.1977.tb07521.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55107261', 'display_name': 'British Journal of Pharmacology', 'issn_l': '0007-1188', 'issn': ['0007-1188', '1476-5381'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.41}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1481575333', 'https://openalex.org/W1965166997', 'https://openalex.org/W1965401354', 'https://openalex.org/W1988707503', 'https://openalex.org/W2010051841', 'https://openalex.org/W2022304550', 'https://openalex.org/W2026325933', 'https://openalex.org/W2029096988', 'https://openalex.org/W2041935994', 'https://openalex.org/W2045140336', 'https://openalex.org/W2049491008', 'https://openalex.org/W2054448165', 'https://openalex.org/W2054951528', 'https://openalex.org/W2083773215', 'https://openalex.org/W2085721380', 'https://openalex.org/W2089462923', 'https://openalex.org/W2134442194', 'https://openalex.org/W2320556745'], 'related_works': ['https://openalex.org/W2441238792', 'https://openalex.org/W2431889295', 'https://openalex.org/W2405472671', 'https://openalex.org/W2159852654', 'https://openalex.org/W2131292729', 'https://openalex.org/W2094349951', 'https://openalex.org/W2084441425', 'https://openalex.org/W2071047222', 'https://openalex.org/W2034150611', 'https://openalex.org/W1995634839'], 'abstract_inverted_index': {'1': [0], 'A': [1], 'series': [2], 'of': [3, 24, 42, 57, 75, 89, 94, 101, 119, 138, 150, 210, 223, 239, 254, 260, 281], 'peptides': [4], 'derived': [5], 'from': [6], 'porcine': [7], 'lipotropin': [8], 'was': [9, 68, 130, 159, 247, 286], 'examined': [10], 'for': [11], 'analgesic': [12, 176, 204, 245, 271], 'and': [13, 71, 106, 170, 213], 'other': [14, 34, 278], 'morphine-like': [15, 35, 79, 279], 'properties': [16], 'on': [17, 62], 'infusion': [18], 'into': [19], 'the': [20, 66, 90, 95, 109, 268, 283, 289], 'cannulated': [21], 'third': [22], 'ventricle': [23], 'cats.2': [25], 'Lipotropin': [26], '(LPH': [27, 46, 166, 193], '1-91)': [28], 'itself': [29], 'produced': [30, 48, 127, 145, 179, 196, 232, 277], 'no': [31, 175, 203], 'analgesia': [32, 51, 146, 182, 200, 234], 'or': [33, 59, 178, 201], 'effects': [36, 80, 280, 290], 'when': [37, 52, 183, 206, 235], 'infused': [38, 53, 134, 184, 207, 236], 'in': [39, 54, 135, 185, 208, 219, 237], 'a': [40, 55, 63, 136, 148], 'dose': [41, 56, 137, 149], '150': [43, 240], 'mug.3': [44], 'C-fragment': [45, 133, 144, 158], '61-91)': [47], 'strong': [49], 'long-lasting': [50, 233], '10': [58], '20': [60], 'mug;': [61, 243], 'molar': [64], 'basis': [65], 'potency': [67, 246], 'between': [69, 211], '90': [70], '180': [72, 242], 'times': [73, 250], 'that': [74, 253], 'morphine.': [76], 'The': [77, 273], 'following': [78], 'were': [81, 113, 226, 291], 'also': [82], 'produced:': [83], 'shivering': [84], 'leading': [85], 'to': [86, 188, 241, 266], 'fever,': [87], 'vasodilatation': [88], 'pinnae,': [91], 'mydriasis,': [92], 'opening': [93], 'palpebral': [96], 'fissures,': [97], 'tachypnoea': [98], 'with': [99, 132, 147, 270], 'bouts': [100], 'panting,': [102], 'vocalization,': [103], 'hyperexcitability,': [104], 'restlessness': [105], 'catalepsy.': [107, 287], 'All': [108, 288], 'effects,': [110], 'including': [111], 'analgesia,': [112], 'abolished': [114, 292], 'by': [115, 128, 155, 230, 293], 'an': [116], 'intraperitoneal': [117, 294], 'injection': [118], 'naloxone': [120, 295], '(1': [121, 296], 'mg/kg).4': [122], 'Hyperglycaemia,': [123], 'another': [124], 'central': [125], 'effect': [126, 177, 205], 'morphine,': [129], 'obtained': [131], '60': [139], 'mug.5': [140], 'On': [141], 'intravenous': [142], 'injection,': [143], 'about': [151], '200': [152], 'mug/kg.': [153], 'Administered': [154], 'this': [156], 'route,': [157], 'again': [160], 'more': [161], 'potent': [162], 'than': [163, 252], 'morphine.6': [164], "C'-fragment": [165], '61-87),': [167], 'LPH': [168, 171], '61-78': [169], '61-69,': [172], 'either': [173, 195], 'had': [174, 202], 'weak': [180, 198], 'short-lasting': [181, 199], 'doses': [186, 209, 238], 'up': [187], '100': [189, 249], 'mug.7': [190], 'Methionine': [191], 'enkephalin': [192, 217, 225, 262], '61-65)': [194], 'very': [197], '30': [212], '400': [214], 'mug.8N-methyl': [215], 'methionine': [216, 224, 261], 'amide': [218, 276], 'which': [220, 282], 'both': [221], 'termini': [222], 'protected': [227], 'against': [228], 'degradation': [229], 'exopeptidases': [231], 'its': [244], 'approximately': [248], 'less': [251], 'C-fragment.': [255], 'Blocking': [256], 'only': [257], 'one': [258], 'terminus': [259], 'did': [263], 'not': [264], 'appear': [265], 'endow': [267], 'peptide': [269], 'properties.': [272], 'N-methyl': [274], 'pentapeptide': [275], 'most': [284], 'striking': [285], 'mg/kg).': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2100818755', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2025-01-08T12:20:34.831262', 'created_date': '2016-06-24'}