Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2100772783', 'doi': 'https://doi.org/10.1038/nbt1358', 'title': 'A quantitative analysis of kinase inhibitor selectivity', 'display_name': 'A quantitative analysis of kinase inhibitor selectivity', 'publication_year': 2008, 'publication_date': '2008-01-01', 'ids': {'openalex': 'https://openalex.org/W2100772783', 'doi': 'https://doi.org/10.1038/nbt1358', 'mag': '2100772783', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18183025'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nbt1358', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106963461', 'display_name': 'Nature Biotechnology', 'issn_l': '1087-0156', 'issn': ['1087-0156', '1546-1696'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009736410', 'display_name': 'Mazen W. Karaman', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mazen W Karaman', 'raw_affiliation_strings': ['Ambit Biosciences, 4215 Sorrento Valley Blvd., San Diego, California 92121, USA.'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, 4215 Sorrento Valley Blvd., San Diego, California 92121, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047433307', 'display_name': 'Sanna Herrgård', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sanna Herrgard', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021209882', 'display_name': 'Daniel K. Treiber', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel K Treiber', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024440471', 'display_name': 'Paul Gallant', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul Gallant', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015497585', 'display_name': 'Corey E. Atteridge', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Corey E Atteridge', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066359360', 'display_name': 'Brian T. Campbell', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian T Campbell', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081239927', 'display_name': 'Katrina Chan', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Katrina W Chan', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034836248', 'display_name': 'Pietro Ciceri', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pietro Ciceri', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045161756', 'display_name': 'Mindy I. Davis', 'orcid': 'https://orcid.org/0000-0002-9557-7376'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mindy I Davis', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067181692', 'display_name': 'Philip T. Edeen', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Philip T Edeen', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084669737', 'display_name': 'Raffaella Faraoni', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raffaella Faraoni', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009690305', 'display_name': 'M. Brawner Floyd', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark Floyd', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102855049', 'display_name': 'Jeremy P. Hunt', 'orcid': 'https://orcid.org/0000-0002-8797-3977'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeremy P Hunt', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015198813', 'display_name': 'Daniel J Lockhart', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel J Lockhart', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052416275', 'display_name': 'Zdravko V. Milanov', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zdravko V Milanov', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035229359', 'display_name': 'Michael J. Morrison', 'orcid': 'https://orcid.org/0000-0002-8948-1773'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael J Morrison', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085914119', 'display_name': 'Gabriel Pallares', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gabriel Pallares', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081183919', 'display_name': 'Hitesh Patel', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hitesh K Patel', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053151212', 'display_name': 'S. Pritchard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephanie Pritchard', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA', 'Present address: Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA.,'], 'affiliations': [{'raw_affiliation_string': 'Present address: Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA.,', 'institution_ids': ['https://openalex.org/I121934306']}, {'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061233633', 'display_name': 'Lisa Wodicka', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lisa M Wodicka', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029530376', 'display_name': 'Patrick P. Zarrinkar', 'orcid': 'https://orcid.org/0000-0003-1601-2236'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrick P Zarrinkar', 'raw_affiliation_strings': ['Ambit Biosciences, San Diego, USA'], 'affiliations': [{'raw_affiliation_string': 'Ambit Biosciences, San Diego, USA', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 201.407, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2290, 'citation_normalized_percentile': {'value': 0.999886, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '26', 'issue': '1', 'first_page': '127', 'last_page': '132'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Methods in Drug Discovery', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10211', 'display_name': 'Computational Methods in Drug Discovery', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/kinome', 'display_name': 'Kinome', 'score': 0.97271764}, {'id': 'https://openalex.org/keywords/map-kinase', 'display_name': 'MAP Kinase', 'score': 0.502564}], 'concepts': [{'id': 'https://openalex.org/C54174078', 'wikidata': 'https://www.wikidata.org/wiki/Q3197188', 'display_name': 'Kinome', 'level': 3, 'score': 0.97271764}, {'id': 'https://openalex.org/C118792377', 'wikidata': 'https://www.wikidata.org/wiki/Q108584245', 'display_name': 'Selectivity', 'level': 3, 'score': 0.72594374}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.60187423}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5711136}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3797604}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31473058}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26994875}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nbt1358', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106963461', 'display_name': 'Nature Biotechnology', 'issn_l': '1087-0156', 'issn': ['1087-0156', '1546-1696'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1603867644', 'https://openalex.org/W1965904237', 'https://openalex.org/W1988464631', 'https://openalex.org/W1988750150', 'https://openalex.org/W1994103352', 'https://openalex.org/W1997926000', 'https://openalex.org/W1999966467', 'https://openalex.org/W2003973314', 'https://openalex.org/W2011588737', 'https://openalex.org/W2014582878', 'https://openalex.org/W2017345038', 'https://openalex.org/W2022884538', 'https://openalex.org/W2022914311', 'https://openalex.org/W2026542427', 'https://openalex.org/W2030205108', 'https://openalex.org/W2037587486', 'https://openalex.org/W2045156702', 'https://openalex.org/W2050422354', 'https://openalex.org/W2059499441', 'https://openalex.org/W2070269476', 'https://openalex.org/W2088123597', 'https://openalex.org/W2097415899', 'https://openalex.org/W2115346062', 'https://openalex.org/W2115363065', 'https://openalex.org/W2116991201', 'https://openalex.org/W2117022661', 'https://openalex.org/W2128307445', 'https://openalex.org/W2134094496', 'https://openalex.org/W2139876258', 'https://openalex.org/W2140765540', 'https://openalex.org/W2143877481', 'https://openalex.org/W2151504205', 'https://openalex.org/W2324850882', 'https://openalex.org/W266144130', 'https://openalex.org/W4242903991'], 'related_works': ['https://openalex.org/W4321605991', 'https://openalex.org/W4298137444', 'https://openalex.org/W4296741799', 'https://openalex.org/W3088289817', 'https://openalex.org/W3043167921', 'https://openalex.org/W3015170184', 'https://openalex.org/W2991424847', 'https://openalex.org/W2948125847', 'https://openalex.org/W2608811481', 'https://openalex.org/W2167618007'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2100772783', 'counts_by_year': [{'year': 2024, 'cited_by_count': 56}, {'year': 2023, 'cited_by_count': 118}, {'year': 2022, 'cited_by_count': 86}, {'year': 2021, 'cited_by_count': 89}, {'year': 2020, 'cited_by_count': 114}, {'year': 2019, 'cited_by_count': 121}, {'year': 2018, 'cited_by_count': 124}, {'year': 2017, 'cited_by_count': 127}, {'year': 2016, 'cited_by_count': 145}, {'year': 2015, 'cited_by_count': 128}, {'year': 2014, 'cited_by_count': 155}, {'year': 2013, 'cited_by_count': 204}, {'year': 2012, 'cited_by_count': 222}], 'updated_date': '2024-09-09T01:18:36.056825', 'created_date': '2016-06-24'}