Title: Pharmacokinetic Relationships Between Cinromide and Its Metabolites in the Rhesus Monkey I: 3-Bromocinnamamide, an Active Metabolite
Abstract: Fifty percent of a cinromide dose was metabolized to an active metabolite in the rhesus monkey. The steady-state concentration of this metabolite was 3-6 times that of the parent drug, depending on the route of administration. Cinromide is a medium-extraction ratio drug with a short half-life (0.92±0.23 hr) when compared with the active metabolite, which has a low extraction ratio and a longer half-life (4.43±0.76 hr). Incomplete oral bioavailability of cinromide is a result of first-pass metabolism rather than incomplete absorption.
Publication Year: 1983
Publication Date: 1983-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 4
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot