Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2100624477', 'doi': 'https://doi.org/10.3109/15412555.2013.771163', 'title': 'Alpha-1 Antitrypsin Augmentation Therapy and Biomarkers of Elastin Degradation', 'display_name': 'Alpha-1 Antitrypsin Augmentation Therapy and Biomarkers of Elastin Degradation', 'publication_year': 2013, 'publication_date': '2013-04-05', 'ids': {'openalex': 'https://openalex.org/W2100624477', 'doi': 'https://doi.org/10.3109/15412555.2013.771163', 'mag': '2100624477', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23560990'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3109/15412555.2013.771163', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.3109/15412555.2013.771163?needAccess=true', 'source': {'id': 'https://openalex.org/S15387528', 'display_name': 'COPD Journal of Chronic Obstructive Pulmonary Disease', 'issn_l': '1541-2563', 'issn': ['1541-2563', '1541-2555'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320449', 'host_organization_name': 'Informa', 'host_organization_lineage': ['https://openalex.org/P4310320449'], 'host_organization_lineage_names': ['Informa'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.tandfonline.com/doi/pdf/10.3109/15412555.2013.771163?needAccess=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000033516', 'display_name': 'Shuren Ma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1321572752', 'display_name': "St. Luke's-Roosevelt Hospital Center", 'ror': 'https://ror.org/011t2cn48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1321572752']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shuren Ma', 'raw_affiliation_strings': ["2St. Luke's-Roosevelt Hospital Center,\rNew York, NY, USA", '4Columbia College of Physicians and Surgeons,\rNew York, NY, USA', 'James P. Mara Center for Lung Disease, New York, NY, USA.'], 'affiliations': [{'raw_affiliation_string': 'James P. Mara Center for Lung Disease, New York, NY, USA.', 'institution_ids': []}, {'raw_affiliation_string': "2St. Luke's-Roosevelt Hospital Center,\rNew York, NY, USA", 'institution_ids': ['https://openalex.org/I1321572752']}, {'raw_affiliation_string': '4Columbia College of Physicians and Surgeons,\rNew York, NY, USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101462552', 'display_name': 'Yong Y. Lin', 'orcid': 'https://orcid.org/0000-0001-7359-3933'}, 'institutions': [{'id': 'https://openalex.org/I1321572752', 'display_name': "St. Luke's-Roosevelt Hospital Center", 'ror': 'https://ror.org/011t2cn48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1321572752']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yong Y. Lin', 'raw_affiliation_strings': ['1James P. Mara Center for Lung Disease,\rNew York, NY, USA', "2St. Luke's-Roosevelt Hospital Center,\rNew York, NY, USA"], 'affiliations': [{'raw_affiliation_string': '1James P. Mara Center for Lung Disease,\rNew York, NY, USA', 'institution_ids': []}, {'raw_affiliation_string': "2St. Luke's-Roosevelt Hospital Center,\rNew York, NY, USA", 'institution_ids': ['https://openalex.org/I1321572752']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079560066', 'display_name': 'Jiangtao He', 'orcid': 'https://orcid.org/0009-0006-9425-3835'}, 'institutions': [{'id': 'https://openalex.org/I1321572752', 'display_name': "St. Luke's-Roosevelt Hospital Center", 'ror': 'https://ror.org/011t2cn48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1321572752']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jiangtao He', 'raw_affiliation_strings': ['1James P. Mara Center for Lung Disease,\rNew York, NY, USA', "2St. Luke's-Roosevelt Hospital Center,\rNew York, NY, USA", '4Columbia College of Physicians and Surgeons,\rNew York, NY, USA'], 'affiliations': [{'raw_affiliation_string': '1James P. Mara Center for Lung Disease,\rNew York, NY, USA', 'institution_ids': []}, {'raw_affiliation_string': "2St. Luke's-Roosevelt Hospital Center,\rNew York, NY, USA", 'institution_ids': ['https://openalex.org/I1321572752']}, {'raw_affiliation_string': '4Columbia College of Physicians and Surgeons,\rNew York, NY, USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083891246', 'display_name': 'Farshid N. Rouhani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144929', 'display_name': 'Alpha-1 Foundation', 'ror': 'https://ror.org/04t31bx63', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210144929']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Farshid N. Rouhani', 'raw_affiliation_strings': ['3Alpha Tissue Bank of the Alpha-1 Foundation, University of Florida,\rMiami, FL, USA'], 'affiliations': [{'raw_affiliation_string': '3Alpha Tissue Bank of the Alpha-1 Foundation, University of Florida,\rMiami, FL, USA', 'institution_ids': ['https://openalex.org/I4210144929']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057923691', 'display_name': 'Mark Brantly', 'orcid': 'https://orcid.org/0000-0003-0189-1565'}, 'institutions': [{'id': 'https://openalex.org/I4210144929', 'display_name': 'Alpha-1 Foundation', 'ror': 'https://ror.org/04t31bx63', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210144929']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark Brantly', 'raw_affiliation_strings': ['3Alpha Tissue Bank of the Alpha-1 Foundation, University of Florida,\rMiami, FL, USA'], 'affiliations': [{'raw_affiliation_string': '3Alpha Tissue Bank of the Alpha-1 Foundation, University of Florida,\rMiami, FL, USA', 'institution_ids': ['https://openalex.org/I4210144929']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036604754', 'display_name': 'Gerard M. Turino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1321572752', 'display_name': "St. Luke's-Roosevelt Hospital Center", 'ror': 'https://ror.org/011t2cn48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1321572752']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerard M. Turino', 'raw_affiliation_strings': ['1James P. Mara Center for Lung Disease,\rNew York, NY, USA', "2St. Luke's-Roosevelt Hospital Center,\rNew York, NY, USA", '4Columbia College of Physicians and Surgeons,\rNew York, NY, USA'], 'affiliations': [{'raw_affiliation_string': '1James P. Mara Center for Lung Disease,\rNew York, NY, USA', 'institution_ids': []}, {'raw_affiliation_string': "2St. Luke's-Roosevelt Hospital Center,\rNew York, NY, USA", 'institution_ids': ['https://openalex.org/I1321572752']}, {'raw_affiliation_string': '4Columbia College of Physicians and Surgeons,\rNew York, NY, USA', 'institution_ids': ['https://openalex.org/I78577930']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2650, 'currency': 'USD', 'value_usd': 2650, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.029, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.909124, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '10', 'issue': '4', 'first_page': '473', 'last_page': '481'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10549', 'display_name': 'Neonatal Lung Development and Respiratory Morbidity', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10549', 'display_name': 'Neonatal Lung Development and Respiratory Morbidity', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11356', 'display_name': 'Diagnosis and Management of Pleural Diseases', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10143', 'display_name': 'Standardisation and Management of COPD', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/desmosine', 'display_name': 'Desmosine', 'score': 0.78305185}, {'id': 'https://openalex.org/keywords/alpha-1-antitrypsin-deficiency', 'display_name': 'Alpha 1-antitrypsin deficiency', 'score': 0.6319652}, {'id': 'https://openalex.org/keywords/neutrophil-elastase', 'display_name': 'Neutrophil elastase', 'score': 0.6166426}, {'id': 'https://openalex.org/keywords/diagnosis', 'display_name': 'Diagnosis', 'score': 0.483918}, {'id': 'https://openalex.org/keywords/pancreatic-elastase', 'display_name': 'Pancreatic elastase', 'score': 0.46177495}], 'concepts': [{'id': 'https://openalex.org/C2779869378', 'wikidata': 'https://www.wikidata.org/wiki/Q409747', 'display_name': 'Elastin', 'level': 2, 'score': 0.9759148}, {'id': 'https://openalex.org/C2777961210', 'wikidata': 'https://www.wikidata.org/wiki/Q927148', 'display_name': 'Bronchoalveolar lavage', 'level': 3, 'score': 0.8059658}, {'id': 'https://openalex.org/C2780638554', 'wikidata': 'https://www.wikidata.org/wiki/Q61184', 'display_name': 'Desmosine', 'level': 3, 'score': 0.78305185}, {'id': 'https://openalex.org/C2781044401', 'wikidata': 'https://www.wikidata.org/wiki/Q418897', 'display_name': 'Elastase', 'level': 3, 'score': 0.7303233}, {'id': 'https://openalex.org/C2780535462', 'wikidata': 'https://www.wikidata.org/wiki/Q622437', 'display_name': 'Alpha 1-antitrypsin deficiency', 'level': 2, 'score': 0.6319652}, {'id': 'https://openalex.org/C2776317360', 'wikidata': 'https://www.wikidata.org/wiki/Q14905648', 'display_name': 'Neutrophil elastase', 'level': 3, 'score': 0.6166426}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6055191}, {'id': 'https://openalex.org/C2780026642', 'wikidata': 'https://www.wikidata.org/wiki/Q40924', 'display_name': 'Urine', 'level': 2, 'score': 0.5280075}, {'id': 'https://openalex.org/C2776326425', 'wikidata': 'https://www.wikidata.org/wiki/Q976747', 'display_name': 'Pancreatic elastase', 'level': 4, 'score': 0.46177495}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.4342816}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35060227}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.27776295}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.20524007}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.20184502}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15339911}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.09108037}], 'mesh': [{'descriptor_ui': 'D004549', 'descriptor_name': 'Elastin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007524', 'descriptor_name': 'Isodesmosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014361', 'descriptor_name': 'Trypsin Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D019896', 'descriptor_name': 'alpha 1-Antitrypsin Deficiency', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019896', 'descriptor_name': 'alpha 1-Antitrypsin Deficiency', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001992', 'descriptor_name': 'Bronchoalveolar Lavage Fluid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004549', 'descriptor_name': 'Elastin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006720', 'descriptor_name': 'Homozygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007524', 'descriptor_name': 'Isodesmosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007524', 'descriptor_name': 'Isodesmosine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007524', 'descriptor_name': 'Isodesmosine', 'qualifier_ui': 'Q000652', 'qualifier_name': 'urine', 'is_major_topic': False}, {'descriptor_ui': 'D019272', 'descriptor_name': 'Leukocyte Elastase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019272', 'descriptor_name': 'Leukocyte Elastase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D019272', 'descriptor_name': 'Leukocyte Elastase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014361', 'descriptor_name': 'Trypsin Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D014361', 'descriptor_name': 'Trypsin Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000515', 'descriptor_name': 'alpha 1-Antitrypsin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D019896', 'descriptor_name': 'alpha 1-Antitrypsin Deficiency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019896', 'descriptor_name': 'alpha 1-Antitrypsin Deficiency', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3109/15412555.2013.771163', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.3109/15412555.2013.771163?needAccess=true', 'source': {'id': 'https://openalex.org/S15387528', 'display_name': 'COPD Journal of Chronic Obstructive Pulmonary Disease', 'issn_l': '1541-2563', 'issn': ['1541-2563', '1541-2555'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320449', 'host_organization_name': 'Informa', 'host_organization_lineage': ['https://openalex.org/P4310320449'], 'host_organization_lineage_names': ['Informa'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23560990', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3109/15412555.2013.771163', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.3109/15412555.2013.771163?needAccess=true', 'source': {'id': 'https://openalex.org/S15387528', 'display_name': 'COPD Journal of Chronic Obstructive Pulmonary Disease', 'issn_l': '1541-2563', 'issn': ['1541-2563', '1541-2555'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320449', 'host_organization_name': 'Informa', 'host_organization_lineage': ['https://openalex.org/P4310320449'], 'host_organization_lineage_names': ['Informa'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1729332853', 'https://openalex.org/W1970751814', 'https://openalex.org/W1976008108', 'https://openalex.org/W1980575540', 'https://openalex.org/W1981091390', 'https://openalex.org/W1985145771', 'https://openalex.org/W1997541030', 'https://openalex.org/W2015074868', 'https://openalex.org/W2016736317', 'https://openalex.org/W2037179043', 'https://openalex.org/W2058643554', 'https://openalex.org/W2070855910', 'https://openalex.org/W2073908813', 'https://openalex.org/W2100358516', 'https://openalex.org/W2104081530', 'https://openalex.org/W2112093011', 'https://openalex.org/W2129707656', 'https://openalex.org/W2131703919', 'https://openalex.org/W2323886210', 'https://openalex.org/W2330039999'], 'related_works': ['https://openalex.org/W2463225206', 'https://openalex.org/W2100624477', 'https://openalex.org/W2080770088', 'https://openalex.org/W2070861468', 'https://openalex.org/W2038945158', 'https://openalex.org/W2023319309', 'https://openalex.org/W2016736317', 'https://openalex.org/W2008359786', 'https://openalex.org/W1988506132', 'https://openalex.org/W1805008252'], 'abstract_inverted_index': {'Intravenous': [0], 'alpha-1': [1, 14], 'antitrypsin': [2, 15], 'protein': [3], '(AAT)': [4], 'augmentation': [5, 78, 143, 151, 170, 201], 'is': [6], 'a': [7, 18, 25, 43], 'prescribed': [8, 197, 220], 'therapy': [9, 79, 171], 'for': [10, 21], 'severe,': [11], 'genetically': [12], 'determined,': [13], 'deficiency': [16], '(AATD),': [17], 'genetic': [19], 'basis': [20], 'pulmonary': [22], 'emphysema.': [23], 'AAT,': [24], 'predominant': [26], 'systemic': [27], 'inhibitor': [28], 'of': [29, 46, 53, 60, 62, 100, 107, 135, 150, 189, 199], 'neutrophil': [30, 203], 'elastase': [31, 204], 'thus': [32], 'far': [33], 'has': [34], 'not': [35, 141, 176, 223], 'been': [36], 'shown': [37], 'to': [38, 57, 122, 206, 227], 'decrease': [39], 'elastin': [40, 63, 108, 208, 225], 'degradation': [41, 64, 106, 226], 'in': [42, 65, 80, 90, 96, 102, 126, 133, 155, 159, 164, 187, 191, 213], 'significant': [44, 153, 185], 'number': [45], 'patients': [47, 81, 138, 166], 'on': [48, 139, 142], 'this': [49, 54], 'therapy.': [50], 'The': [51, 218], 'objective': [52], 'study': [55], 'was': [56, 120], 'compare': [58], 'levels': [59, 125, 188], 'biomarkers': [61], 'plasma,': [66, 127], 'bronchoalveolar': [67, 128], 'lavage': [68, 129], '(BALF)': [69], 'fluid': [70, 130], 'and': [71, 74, 84, 109, 131, 144, 146, 158, 212], 'urine': [72, 132], 'before': [73, 145], 'after': [75, 147], 'beginning': [76], 'AAT': [77, 200], 'with': [82, 174, 234], 'AATD.Desmosine': [83], 'isodesmosine': [85], '(DI),': [86], 'which': [87, 230], 'occur': [88], 'only': [89], 'elastin,': [91], 'are': [92], 'amino': [93], 'acid': [94], 'cross-links': [95], 'mature': [97], 'elastin.': [98], 'Levels': [99], 'DI': [101, 124, 157, 161, 190], 'body': [103], 'fluids': [104], 'measure': [105, 123], 'can': [110], 'be': [111, 232], 'measured': [112], 'more': [113], 'specifically': [114], 'by': [115, 180], 'mass': [116], 'spectrometry.': [117], 'This': [118], 'method': [119], 'used': [121], 'cohorts': [134], 'severe': [136], 'AATD': [137, 165], 'augmentation,': [140], 'the': [148, 195, 214], 'initiation': [149], 'therapy.Statistically': [152], 'reductions': [154, 186], 'plasma': [156], 'BALF': [160], 'were': [162], 'demonstrated': [163], 'receiving': [167, 177], 'intravenous': [168], '(IV)': [169], 'as': [172], 'compared': [173], 'those': [175], 'it.': [178], 'Administration': [179], 'aerosol': [181], 'also': [182], 'produced': [183], 'statistically': [184], 'BALF.Results': [192], 'indicate': [193], 'that': [194], 'currently': [196, 219], 'doses': [198, 221], 'inhibit': [202], 'adequately': [205], 'reduce': [207, 224], 'degradation,': [209], 'both': [210], 'systemically': [211], 'lung': [215], 'per': [216], 'se.': [217], 'did': [222], 'control': [228], 'levels,': [229], 'may': [231], 'possible': [233], 'higher': [235], 'doses.': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2100624477', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2024-09-14T04:42:38.848826', 'created_date': '2016-06-24'}