Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2100605275', 'doi': 'https://doi.org/10.1101/gad.490608', 'title': 'NF1 loss disrupts Schwann cell–axonal interactions: a novel role for semaphorin 4F', 'display_name': 'NF1 loss disrupts Schwann cell–axonal interactions: a novel role for semaphorin 4F', 'publication_year': 2008, 'publication_date': '2008-12-01', 'ids': {'openalex': 'https://openalex.org/W2100605275', 'doi': 'https://doi.org/10.1101/gad.490608', 'mag': '2100605275', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19056885', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2600763'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.490608', 'pdf_url': 'http://genesdev.cshlp.org/content/22/23/3335.full.pdf', 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://genesdev.cshlp.org/content/22/23/3335.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000443472', 'display_name': 'Simona Parrinello', 'orcid': 'https://orcid.org/0000-0003-0820-6292'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Simona Parrinello', 'raw_affiliation_strings': ['MRC Laboratory for Molecular Cell Biology, Department of Cell and Developmental Biology and the UCL Cancer Institute, University College London, London WC1E 6BT, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory for Molecular Cell Biology, Department of Cell and Developmental Biology and the UCL Cancer Institute, University College London, London WC1E 6BT, United Kingdom.', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047383843', 'display_name': 'Luke A. Noon', 'orcid': 'https://orcid.org/0000-0002-0502-4322'}, 'institutions': [{'id': 'https://openalex.org/I2800173700', 'display_name': 'UCL Australia', 'ror': 'https://ror.org/024atcf19', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I2800173700']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Luke A. Noon', 'raw_affiliation_strings': ['University college London'], 'affiliations': [{'raw_affiliation_string': 'University college London', 'institution_ids': ['https://openalex.org/I2800173700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060551386', 'display_name': 'Marie C. Harrisingh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marie C. Harrisingh', 'raw_affiliation_strings': ['Yale University ;'], 'affiliations': [{'raw_affiliation_string': 'Yale University ;', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068494700', 'display_name': 'Patrick Wingfield Digby', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800173700', 'display_name': 'UCL Australia', 'ror': 'https://ror.org/024atcf19', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I2800173700']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Patrick Wingfield Digby', 'raw_affiliation_strings': ['University college London'], 'affiliations': [{'raw_affiliation_string': 'University college London', 'institution_ids': ['https://openalex.org/I2800173700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021351018', 'display_name': 'Laura H. Rosenberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800173700', 'display_name': 'UCL Australia', 'ror': 'https://ror.org/024atcf19', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I2800173700']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Laura H. Rosenberg', 'raw_affiliation_strings': ['University college London'], 'affiliations': [{'raw_affiliation_string': 'University college London', 'institution_ids': ['https://openalex.org/I2800173700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057420657', 'display_name': 'Catherine A. Cremona', 'orcid': 'https://orcid.org/0000-0002-5962-7399'}, 'institutions': [{'id': 'https://openalex.org/I2800173700', 'display_name': 'UCL Australia', 'ror': 'https://ror.org/024atcf19', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I2800173700']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Catherine A. Cremona', 'raw_affiliation_strings': ['University college London'], 'affiliations': [{'raw_affiliation_string': 'University college London', 'institution_ids': ['https://openalex.org/I2800173700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072374459', 'display_name': 'Pedro Echave', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800173700', 'display_name': 'UCL Australia', 'ror': 'https://ror.org/024atcf19', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I2800173700']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Pedro Echave', 'raw_affiliation_strings': ['University college London'], 'affiliations': [{'raw_affiliation_string': 'University college London', 'institution_ids': ['https://openalex.org/I2800173700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049499439', 'display_name': 'Adrienne M. Flanagan', 'orcid': 'https://orcid.org/0000-0002-2832-1303'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2802751111', 'display_name': 'Royal National Orthopaedic Hospital', 'ror': 'https://ror.org/043j9bc42', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802751111', 'https://openalex.org/I4210118734']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Adrienne M. Flanagan', 'raw_affiliation_strings': ['Royal National Orthopaedic Hospital,'], 'affiliations': [{'raw_affiliation_string': 'Royal National Orthopaedic Hospital,', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2802751111']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005276553', 'display_name': 'Luis F. Parada', 'orcid': 'https://orcid.org/0000-0003-2295-1432'}, 'institutions': [{'id': 'https://openalex.org/I4210127327', 'display_name': 'Institute of Developmental Physiology', 'ror': 'https://ror.org/035rr9c26', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210127327']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Luis F. Parada', 'raw_affiliation_strings': ['Developmental Biology'], 'affiliations': [{'raw_affiliation_string': 'Developmental Biology', 'institution_ids': ['https://openalex.org/I4210127327']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068403701', 'display_name': 'Alison C. Lloyd', 'orcid': 'https://orcid.org/0000-0001-7712-1773'}, 'institutions': [{'id': 'https://openalex.org/I2800173700', 'display_name': 'UCL Australia', 'ror': 'https://ror.org/024atcf19', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I2800173700']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Alison C. Lloyd', 'raw_affiliation_strings': ['University college London'], 'affiliations': [{'raw_affiliation_string': 'University college London', 'institution_ids': ['https://openalex.org/I2800173700']}]}], 'countries_distinct_count': 4, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.333, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.906538, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '22', 'issue': '23', 'first_page': '3335', 'last_page': '3348'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11173', 'display_name': 'Neurofibromatosis Type 1 and Type 2', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Roles of Neurotrophins in Nervous System Function', 'score': 0.9771, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurofibromin-1', 'display_name': 'Neurofibromin 1', 'score': 0.9302275}, {'id': 'https://openalex.org/keywords/schwann-cell', 'display_name': 'Schwann cell', 'score': 0.73524994}, {'id': 'https://openalex.org/keywords/neurofibromatosis', 'display_name': 'Neurofibromatosis', 'score': 0.556928}, {'id': 'https://openalex.org/keywords/schwann-cells', 'display_name': 'Schwann Cells', 'score': 0.540014}, {'id': 'https://openalex.org/keywords/plexin', 'display_name': 'Plexin', 'score': 0.42680192}], 'concepts': [{'id': 'https://openalex.org/C170932241', 'wikidata': 'https://www.wikidata.org/wiki/Q411610', 'display_name': 'Neurofibromin 1', 'level': 3, 'score': 0.9302275}, {'id': 'https://openalex.org/C132538176', 'wikidata': 'https://www.wikidata.org/wiki/Q24768287', 'display_name': 'Semaphorin', 'level': 3, 'score': 0.7782501}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7385411}, {'id': 'https://openalex.org/C2777004073', 'wikidata': 'https://www.wikidata.org/wiki/Q465621', 'display_name': 'Schwann cell', 'level': 2, 'score': 0.73524994}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5789978}, {'id': 'https://openalex.org/C2777831590', 'wikidata': 'https://www.wikidata.org/wiki/Q1418735', 'display_name': 'Neurofibroma', 'level': 3, 'score': 0.57313395}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.5437783}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.49337903}, {'id': 'https://openalex.org/C2778984943', 'wikidata': 'https://www.wikidata.org/wiki/Q847605', 'display_name': 'Neurofibromatosis', 'level': 2, 'score': 0.47920546}, {'id': 'https://openalex.org/C2779841796', 'wikidata': 'https://www.wikidata.org/wiki/Q1188964', 'display_name': 'Plexin', 'level': 4, 'score': 0.42680192}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4210961}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.4105419}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.29120344}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.18384248}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.17640403}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13955435}], 'mesh': [{'descriptor_ui': 'D001369', 'descriptor_name': 'Axons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D025542', 'descriptor_name': 'Neurofibromin 1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012583', 'descriptor_name': 'Schwann Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001369', 'descriptor_name': 'Axons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018920', 'descriptor_name': 'Coculture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009455', 'descriptor_name': 'Neurofibroma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009455', 'descriptor_name': 'Neurofibroma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D025542', 'descriptor_name': 'Neurofibromin 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012583', 'descriptor_name': 'Schwann Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012583', 'descriptor_name': 'Schwann Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039961', 'descriptor_name': 'Semaphorins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D039961', 'descriptor_name': 'Semaphorins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.490608', 'pdf_url': 'http://genesdev.cshlp.org/content/22/23/3335.full.pdf', 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2600763', 'pdf_url': 'https://europepmc.org/articles/pmc2600763?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/20.500.11820/27313caf-5c01-483f-ad7c-608cf5dd3318', 'pdf_url': 'https://www.research.ed.ac.uk/files/12454284/NF1_loss_disrupts_Schwann_cell_axonal_interactions_a_novel_role_for_semaphorin_4F.pdf', 'source': {'id': 'https://openalex.org/S4306400321', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.pure.ed.ac.uk/ws/files/12454284/NF1_loss_disrupts_Schwann_cell_axonal_interactions_a_novel_role_for_semaphorin_4F.pdf', 'pdf_url': 'https://www.pure.ed.ac.uk/ws/files/12454284/NF1_loss_disrupts_Schwann_cell_axonal_interactions_a_novel_role_for_semaphorin_4F.pdf', 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600763', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19056885', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/gad.490608', 'pdf_url': 'http://genesdev.cshlp.org/content/22/23/3335.full.pdf', 'source': {'id': 'https://openalex.org/S168778273', 'display_name': 'Genes & Development', 'issn_l': '0890-9369', 'issn': ['0890-9369', '1549-5477'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.75, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W106570787', 'https://openalex.org/W1243134829', 'https://openalex.org/W1499500424', 'https://openalex.org/W1499621409', 'https://openalex.org/W1506635126', 'https://openalex.org/W1588935895', 'https://openalex.org/W1604048375', 'https://openalex.org/W1948328269', 'https://openalex.org/W1962474309', 'https://openalex.org/W1963838613', 'https://openalex.org/W1969552240', 'https://openalex.org/W1975063093', 'https://openalex.org/W1985746223', 'https://openalex.org/W1989480480', 'https://openalex.org/W1990020261', 'https://openalex.org/W1998114694', 'https://openalex.org/W1998279268', 'https://openalex.org/W2000762378', 'https://openalex.org/W2004377723', 'https://openalex.org/W2012828388', 'https://openalex.org/W2020231002', 'https://openalex.org/W2026197921', 'https://openalex.org/W2032346608', 'https://openalex.org/W2046822015', 'https://openalex.org/W2047220113', 'https://openalex.org/W2054674800', 'https://openalex.org/W2059476607', 'https://openalex.org/W2066815390', 'https://openalex.org/W2070287558', 'https://openalex.org/W2072478579', 'https://openalex.org/W2072613052', 'https://openalex.org/W2081304354', 'https://openalex.org/W2089735999', 'https://openalex.org/W2092322285', 'https://openalex.org/W2111471852', 'https://openalex.org/W2113404473', 'https://openalex.org/W2118941096', 'https://openalex.org/W2133392593', 'https://openalex.org/W2146326641', 'https://openalex.org/W2146978754', 'https://openalex.org/W2168441639', 'https://openalex.org/W2339678451', 'https://openalex.org/W4255204034'], 'related_works': ['https://openalex.org/W3033164912', 'https://openalex.org/W2608511059', 'https://openalex.org/W2172061589', 'https://openalex.org/W2092641793', 'https://openalex.org/W2078056366', 'https://openalex.org/W2070560551', 'https://openalex.org/W2068284746', 'https://openalex.org/W2068224188', 'https://openalex.org/W1990829377', 'https://openalex.org/W1983101401'], 'abstract_inverted_index': {'Neurofibromatosis': [0], 'type': [1], '1': [2], '(NF1)': [3], 'patients': [4], 'develop': [5], 'neurofibromas,': [6, 144], 'tumors': [7], 'of': [8, 15, 17, 34, 51, 69, 83, 92, 105, 127, 142, 148, 168, 197], 'Schwann': [9, 24, 72, 78, 113, 169], 'cell': [10, 114, 183], 'origin,': [11], 'as': [12, 96], 'a': [13, 38, 122, 140, 158, 174, 191], 'result': [14], 'loss': [16, 33, 68, 104, 126], 'the': [18, 48, 84, 97, 102, 146, 152, 162, 166, 195], 'Ras-GAP': [19], 'neurofibromin.': [20], 'In': [21, 107], 'normal': [22], 'nerves,': [23], 'cells': [25, 73], 'are': [26], 'found': [27], 'tightly': [28], 'associated': [29], 'with': [30], 'axons,': [31], 'while': [32], 'axonal': [35, 118, 128], 'contact': [36, 129], 'is': [37, 58, 74], 'frequent': [39], 'and': [40, 172, 185], 'important': [41], 'early': [42], 'event': [43], 'in': [44, 60, 71, 139, 165], 'neurofibroma': [45], 'development.': [46], 'However,': [47], 'molecular': [49, 98, 175], 'basis': [50], 'this': [52], 'physical': [53], 'interaction': [54], 'or': [55], 'how': [56], 'it': [57, 189], 'disrupted': [59], 'cancer': [61], 'remains': [62], 'unclear.': [63], 'Here': [64], 'we': [65, 89], 'show': [66], 'that': [67], 'neurofibromin': [70], 'sufficient': [75], 'to': [76, 131, 151], 'disrupt': [77], 'cell/axonal': [79, 170], 'interactions': [80], 'via': [81], 'up-regulation': [82], 'Ras/Raf/ERK': [85], 'signaling': [86], 'pathway.': [87], 'Importantly,': [88, 133], 'identify': [90], 'down-regulation': [91], 'semaphorin': [93], '4F': [94], '(Sema4F)': [95], 'mechanism': [99, 123, 176], 'responsible': [100], 'for': [101, 161, 194, 199], 'Ras-mediated': [103], 'interactions.': [106], 'heterotypic': [108, 179], 'cocultures,': [109], 'Sema4F': [110, 134], 'knockdown': [111], 'induced': [112], 'proliferation': [115, 184], 'by': [116, 177], 'relieving': [117], 'contact-inhibitory': [119], 'signals,': [120], 'providing': [121], 'through': [124], 'which': [125, 178], 'contributes': [130], 'tumorigenesis.': [132, 187], 'levels': [135], 'were': [136], 'strongly': [137], 'reduced': [138], 'panel': [141], 'human': [143, 153], 'confirming': [145], 'relevance': [147], 'these': [149], 'findings': [150], 'disease.': [154], 'This': [155], 'work': [156], 'identifies': [157], 'novel': [159], 'role': [160], 'guidance-molecules': [163], 'semaphorins': [164], 'mediation': [167], 'interactions,': [171], 'provides': [173, 190], 'cell–cell': [180], 'contacts': [181], 'control': [182], 'suppress': [186], 'Finally,': [188], 'new': [192], 'approach': [193], 'development': [196], 'therapies': [198], 'NF1.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2100605275', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-09T23:13:59.454013', 'created_date': '2016-06-24'}