Title: Enantioselective Construction of Functionalized Thiochromans via Squaramide‐Catalyzed Asymmetric Cascade Sulfa‐Michael/Michael Addition
Abstract: Abstract An efficient enantioselective cascade sulfa‐Michael/Michael addition reaction of trans ‐3‐(2‐mercaptophenyl)‐2‐propenoic acid ethyl ester with nitroalkenes catalyzed by a chiral squaramide catalyst was disclosed. This cascade reaction afforded thiochroman derivatives with three contiguous stereocenters in high yields (up to 94%), excellent diastereoselectivities (up to >25:1 dr ) and enantioselectivities (up to 99% ee ).
Publication Year: 2014
Publication Date: 2014-08-25
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 12
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